                         SEQUENCE LISTING

<110>  Novozymes Biopharma UK Limited
 
<120>  Purification Process

<130>  11248.000-EP

<150>  EP09152332
<151>  2009-02-06

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  679
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(679)
<223>  Homo sapiens transferrin

<400>  1

Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala 
1               5                   10                  15      


Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser 
            20                  25                  30          


Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys 
        35                  40                  45              


Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
    50                  55                  60                  


Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val 
65                  70                  75                  80  


Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr 
                85                  90                  95      


Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu 
            100                 105                 110         


Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
        115                 120                 125             


Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys 
    130                 135                 140                 


Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro 
145                 150                 155                 160 


Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly 
                165                 170                 175     


Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe 
            180                 185                 190         


Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser 
        195                 200                 205             


Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu 
    210                 215                 220                 


Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp 
225                 230                 235                 240 


Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Met 
                245                 250                 255     


Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu 
            260                 265                 270         


His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro 
        275                 280                 285             


His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys 
    290                 295                 300                 


Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val 
305                 310                 315                 320 


Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr 
                325                 330                 335     


Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg 
            340                 345                 350         


Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys 
        355                 360                 365             


Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly 
    370                 375                 380                 


Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly 
385                 390                 395                 400 


Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp 
                405                 410                 415     


Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val 
            420                 425                 430         


Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys 
        435                 440                 445             


Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met 
    450                 455                 460                 


Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe 
465                 470                 475                 480 


Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys 
                485                 490                 495     


Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu 
            500                 505                 510         


Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
        515                 520                 525             


Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
    530                 535                 540                 


Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
545                 550                 555                 560 


Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
                565                 570                 575     


Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
            580                 585                 590         


Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
        595                 600                 605             


Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
    610                 615                 620                 


Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
625                 630                 635                 640 


Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
                645                 650                 655     


Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
            660                 665                 670         


Ala Cys Thr Phe Arg Arg Pro 
        675                 


<210>  2
<211>  691
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(691)
<223>  Homo sapiens lactoferrin

<400>  2

Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala 
1               5                   10                  15      


Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro 
            20                  25                  30          


Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala 
        35                  40                  45              


Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile 
    50                  55                  60                  


Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu 
65                  70                  75                  80  


Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val Ala 
                85                  90                  95      


Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu 
            100                 105                 110         


Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val Pro 
        115                 120                 125             


Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Ala Gly Pro Pro Glu Pro 
    130                 135                 140                 


Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro Gly 
145                 150                 155                 160 


Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly Thr 
                165                 170                 175     


Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser Tyr 
            180                 185                 190         


Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala Phe 
        195                 200                 205             


Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu Arg 
    210                 215                 220                 


Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val Asp 
225                 230                 235                 240 


Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His Ala Val Val 
                245                 250                 255     


Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu Arg 
            260                 265                 270         


Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln Leu 
        275                 280                 285             


Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser Ala 
    290                 295                 300                 


Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr Leu 
305                 310                 315                 320 


Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys Ser Glu Glu 
                325                 330                 335     


Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala Val Gly Glu 
            340                 345                 350         


Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser Glu Gly Ser 
        355                 360                 365             


Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile Ala Leu Val 
    370                 375                 380                 


Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val Tyr 
385                 390                 395                 400 


Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Lys 
                405                 410                 415     


Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro Val 
            420                 425                 430         


Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser Leu 
        435                 440                 445             


Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val Asp 
    450                 455                 460                 


Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln Ala 
465                 470                 475                 480 


Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro Gly 
                485                 490                 495     


Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu Gln 
            500                 505                 510         


Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr 
        515                 520                 525             


Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala Phe 
    530                 535                 540                 


Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn Glu 
545                 550                 555                 560 


Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys Leu 
                565                 570                 575     


Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu Ala 
            580                 585                 590         


Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu Arg 
        595                 600                 605             


Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn Gly 
    610                 615                 620                 


Ala Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys Asn 
625                 630                 635                 640 


Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly Lys 
                645                 650                 655     


Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile Thr 
            660                 665                 670         


Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu Phe 
        675                 680                 685             


Leu Arg Lys 
    690     


<210>  3
<211>  738
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(738)
<223>  Homo sapiens lactoferrin

<400>  3

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  4
<211>  679
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial variant of Homo sapiens transferrin

<400>  4

Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala 
1               5                   10                  15      


Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser 
            20                  25                  30          


Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys 
        35                  40                  45              


Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
    50                  55                  60                  


Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val 
65                  70                  75                  80  


Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr 
                85                  90                  95      


Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu 
            100                 105                 110         


Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
        115                 120                 125             


Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys 
    130                 135                 140                 


Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro 
145                 150                 155                 160 


Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly 
                165                 170                 175     


Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe 
            180                 185                 190         


Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser 
        195                 200                 205             


Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu 
    210                 215                 220                 


Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp 
225                 230                 235                 240 


Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Met 
                245                 250                 255     


Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu 
            260                 265                 270         


His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro 
        275                 280                 285             


His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys 
    290                 295                 300                 


Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val 
305                 310                 315                 320 


Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr 
                325                 330                 335     


Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg 
            340                 345                 350         


Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys 
        355                 360                 365             


Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly 
    370                 375                 380                 


Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly 
385                 390                 395                 400 


Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ala Asp 
                405                 410                 415     


Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val 
            420                 425                 430         


Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys 
        435                 440                 445             


Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met 
    450                 455                 460                 


Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe 
465                 470                 475                 480 


Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys 
                485                 490                 495     


Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu 
            500                 505                 510         


Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
        515                 520                 525             


Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
    530                 535                 540                 


Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
545                 550                 555                 560 


Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
                565                 570                 575     


Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
            580                 585                 590         


Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
        595                 600                 605             


Gly Ser Asn Val Ala Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
    610                 615                 620                 


Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
625                 630                 635                 640 


Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
                645                 650                 655     


Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
            660                 665                 670         


Ala Cys Thr Phe Arg Arg Pro 
        675                 


