                         SEQUENCE LISTING

<110>  Biofocus DPI BV
       Glaxo Group Limited
       Janssen, Richard AJ
       Lekkerkerker, Annemarie N
       De Groot, Anton
       Meldrum, Eric C
       Thompson, Nicola
       Dickson, Marion C
       Ray, Keith P
       Boyce, Susan H
 
<120>  METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS 
       AND TREATMENT OF DISEASES INVOLVING INFLAMMATION

<130>  GAL-P1068PCT

<150>  US 61/208,271
<151>  2009-02-19

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  15391
<212>  DNA
<213>  Homo sapiens

<400>  1
tctacctcgc gggtgcctct ggtgtctcca gaggtctccg accccagccc gcccccagcc       60

ctcccgccca gcccgcagcc ccctccctct gttccccgac ctcagaccct gggcttccga      120

cctcgacatc atgggtgacg cagaaggcga agacgaggtc cagttcctgc ggacggacga      180

tgaggtggtc ctgcagtgca gcgctaccgt gctcaaggag cagctcaagc tctgcctggc      240

cgccgagggc ttcggcaacc gcctgtgctt cctggagccc actagcaacg cgcagaatgt      300

gccccccgat ctggccatct gttgcttcgt cctggagcag tccctgtctg tgcgagccct      360

gcaggagatg ctggctaaca cggtggaggc tggcgtggag tcatcccagg gcgggggaca      420

caggacgctc ctgtatggcc atgccatcct gctccggcat gcacacagcc gcatgtatct      480

gagctgcctc accacctccc gctccatgac tgacaagctg gccttcgatg tgggactgca      540

ggaggacgca acaggagagg cttgctggtg gaccatgcac ccagcctcca agcagaggtc      600

tgaaggagaa aaggtccgcg ttggggatga catcatcctt gtcagtgtct cctccgagcg      660

ctacctgcac ctgtcgaccg ccagtgggga gctccaggtt gacgcttcct tcatgcagac      720

actatggaac atgaacccca tctgctcccg ctgcgaagag ggcttcgtga cgggaggtca      780

cgtcctccgc ctctttcatg gacatatgga tgagtgtctg accatttccc ctgctgacag      840

tgatgaccag cgcagacttg tctactatga ggggggagct gtgtgcactc atgcccgctc      900

cctctggagg ctggagccac tgagaatcag ctggagtggg agccacctgc gctggggcca      960

gccactccga gtccggcatg tcactaccgg gcagtaccta gcgctcaccg aggaccaggg     1020

cctggtggtg gttgacgcca gcaaggctca caccaaggct acctccttct gcttccgcat     1080

ctccaaggag aagctggatg tggcccccaa gcgggatgtg gagggcatgg gcccccctga     1140

gatcaagtac ggggagtcac tgtgcttcgt gcagcatgtg gcctcaggac tgtggctcac     1200

ctatgctgct ccagacccca aggccctgcg gctcggcgtg ctcaagaaga aggccatgct     1260

gcaccaggag ggccacatgg acgacgcact gtcgctgacc cgctgccagc aggaggagtc     1320

ccaggccgcc cgcatgatcc acagcaccaa tggcctatac aaccagttca tcaagagcct     1380

ggacagcttc agcgggaagc cacggggctc ggggccaccc gctggcacgg cgctgcccat     1440

cgagggcgtt atcctgagcc tgcaggacct catcatctac ttcgagcctc cctccgagga     1500

cttgcagcac gaggagaagc agagcaagct gcgaagcctg cgcaaccgcc agagcctctt     1560

ccaggaggag gggatgctct ccatggtcct gaattgcata gaccgcctaa atgtctacac     1620

cactgctgcc cactttgctg agtttgcagg ggaggaggca gccgagtcct ggaaagagat     1680

tgtgaatctt ctctatgaac tcctagcttc tctaatccgt ggcaatcgta gcaactgtgc     1740

cctcttctcc acaaacttgg actggctggt cagcaagctg gatcggctgg aggcctcgtc     1800

tggcatcctg gaggtcctgt actgtgtcct cattgagagt ccagaggttc tgaacatcat     1860

ccaggagaat cacatcaagt ccatcatctc cctcctggac aagcatggga ggaaccacaa     1920

ggtcctggac gtgctatgct ccctgtgtgt gtgtaatggt gtggctgtac gctccaacca     1980

agatcttatt actgagaact tgctgcctgg ccgtgagctt ctgctgcaga caaacctcat     2040

caactatgtc accagcatcc gccccaacat ctttgtgggc cgagcggaag gcaccacgca     2100

gtacagcaaa tggtactttg aggtgatggt ggacgaggtg actccatttc tgacagctca     2160

ggccacccac ttgcgggtgg gctgggccct caccgagggc tacaccccct accctggggc     2220

cggcgagggc tggggcggca acggggtcgg cgatgacctc tattcctacg gctttgatgg     2280

actgcatctc tggacaggac acgtggcacg cccagtgact tccccagggc agcacctcct     2340

ggcccctgaa gacgtgatca gctgctgcct ggacctcagc gtgccgtcca tctccttccg     2400

catcaacggc tgccccgtgc agggtgtctt tgagtccttc aacctggacg ggctcttctt     2460

ccctgttgtc agcttctcgg ctggtgtcaa ggtgcggttc ctccttggtg gccgccatgg     2520

tgaattcaag ttcctgcccc cacctggcta tgctccatgc catgaggctg tgctccctcg     2580

agagcgactc catcttgaac ccatcaagga gtatcgacgg gaggggcccc gggggcctca     2640

cctggtgggc cccagtcgct gcctctcaca caccgacttc gtgccctgcc ctgtggacac     2700

tgtccagatt gtcctgccgc cccatctgga gcgcattcgg gagaagctgg cggagaacat     2760

ccacgagctc tgggcgctaa cccgcatcga gcagggctgg acctacggcc cggttcggga     2820

tgacaacaag aggctgcacc cgtgtcttgt ggacttccac agccttccag agcctgagag     2880

gaactacaac ctgcagatgt ctggggagac gctcaagact ctgctggctc tgggctgcca     2940

cgtgggcatg gcggatgaga aggcggagga caacctgaag aagacaaaac tccccaagac     3000

gtatatgatg agcaatgggt acaagccggc tccgctggac ctgagccacg tgcggctgac     3060

gccggcgcag acgacactgg tggaccgtct ggcagaaaat gggcacaacg tgtgggcccg     3120

agaccgcgtg ggccagggct ggagctacag cgcagtgcag gacatcccag cgcgccgaaa     3180

ccctcggctg gtgccctacc gcctgctgga tgaagccacc aagcgcagca accgggacag     3240

cctctgccag gccgtgcgca ccctcctggg ctacggctac aacatcgagc ctcctgacca     3300

ggagcccagt caggtggaga accagtctcg ttgtgaccgg gtgcgcatct tccgggcaga     3360

gaaatcctat acagtgcaga gcggccgctg gtacttcgag tttgaagcag tcaccacagg     3420

cgagatgcgc gtgggctggg cgaggcccga gctgaggcct gatgtagagc tgggagctga     3480

cgagctggcc tatgtcttca atgggcaccg cggccagcgc tggcacttgg gcagtgaacc     3540

atttgggcgc ccctggcagc cgggcgatgt cgttggctgt atgatcgacc tcacagagaa     3600

caccattatc ttcaccctca atggcgaggt cctcatgtct gactcaggct ccgaaacagc     3660

cttccgggag attgagattg gggacggctt cctgcccgtc tgcagcttgg gacctggcca     3720

ggtgggtcat ctgaacctgg gccaggacgt gagctctctg aggttctttg ccatctgtgg     3780

cctccaggaa ggcttcgagc catttgccat caacatgcag cgcccagtca ccacctggtt     3840

cagcaaaggc ctgccccagt ttgagccagt gccccttgaa caccctcact atgaggtatc     3900

ccgagtggac ggcactgtgg acacgccccc ctgcctgcgc ctgacccacc gcacctgggg     3960

ctcccagaac agcctggtgg agatgctttt cctgcggctg agcctcccag tccagttcca     4020

ccagcacttc cgctgcactg caggggccac cccgctggca cctcctggcc tgcagccccc     4080

cgccgaggac gaggcccggg cggcggaacc cgaccctgac tacgaaaacc tgcgccgctc     4140

agctgggggc tggagcgagg cagagaacgg caaagaaggg actgcgaagg agggcgcccc     4200

cgggggcacc ccgcaggcgg ggggagaggc gcagcccgcc agggcggaga atgagaagga     4260

tgccaccacc gagaagaaca agaagagagg cttcttattc aaggccaaga aggtcgccat     4320

gatgacccag ccaccggcca cccccacgct gccccgactc cctcacgacg tggtgcctgc     4380

agacaaccgc gatgaccccg agatcatcct caacaccacc acgtactatt actccgtgag     4440

ggtctttgct ggacaggagc ccagctgcgt gtgggcgggc tgggtcaccc ctgactacca     4500

tcagcacgac atgagcttcg acctcagcaa ggtccgggtc gtgacggtga ccatggggga     4560

tgaacaaggc aacgtccaca gcagcctcaa gtgtagcaac tgctacatgg tgtggggcgg     4620

agactttgtg agtcccgggc agcagggccg gatcagccac acggaccttg tcattgggtg     4680

cctggtggac ttggccactg gcttaatgac ctttacagcc aatggcaaag agagcaacac     4740

ctttttccag gtggaaccca acactaagct atttcctgcc gtcttcgtcc tgcccaccca     4800

ccagaacgtc atccagtttg agctggggaa gcagaagaac atcatgccgt tgtcagccgc     4860

catgttccaa agcgagcgca agaacccggc cccgcagtgc ccaccgcggc tggagatgca     4920

gatgctgatg ccagtgtcct ggagccgcat gcccaaccac ttcctgcagg tggagacgag     4980

gcgtgccggc gagcggctgg gctgggccgt gcagtgccag gagccgctga ccatgatggc     5040

gctgcacatc cccgaggaga accggtgcat ggacatcctg gagctgtcgg agcgcctgga     5100

cctgcagcgc ttccactcgc acaccctgcg cctctaccgc gctgtgtgcg ccctgggcaa     5160

caatcgcgtg gcgcacgctc tgtgcagcca cgtagaccaa gctcagctgc tgcacgccct     5220

ggaggacgcg cacctgccag gcccactgcg cgcaggctac tatgacctcc tcatcagcat     5280

ccacctcgaa agtgcctgcc gcagccgccg ctccatgctc tctgaataca tcgtgcccct     5340

cacgcctgag acccgcgcca tcacgctctt ccctcctgga aggagcacag aaaatggtca     5400

cccccggcat ggcctgccgg gagttggagt caccacttcg ctgaggcccc cgcatcattt     5460

ctcgcccccc tgtttcgtgg ccgctctgcc agctgctggg gcagcagagg ccccggcccg     5520

cctcagccct gccatcccgc tggaggccct gcgggacaag gcactgagga tgctggggga     5580

ggcggtgcgc gacggtgggc agcacgctcg cgaccccgtc gggggctccg tggagttcca     5640

gtttgtgcct gtgctcaagc tcgtgtccac cctgctggtg atgggcatct ttggcgatga     5700

ggatgtgaaa cagatcttga agatgattga gcctgaggtc ttcactgagg aagaagagga     5760

ggaggacgag gaggaagagg gtgaagagga agatgaggag gagaaggagg aggatgagga     5820

ggaaacagca caggaaaagg aagatgagga aaaagaggaa gaggaggcag cagaagggga     5880

gaaagaagaa ggcttggagg aagggctgct ccagatgaag ttgccagagt ctgtgaagtt     5940

acagatgtgc cacctgctgg agtatttctg tgaccaagag ctgcagcacc gtgtggagtc     6000

cctggcagcc tttgcggagc gctatgtgga caagctccag gccaaccagc ggagccgcta     6060

tggcctcctc ataaaagcct tcagcatgac cgcagcagag actgcaagac gtacccgcga     6120

gttccgctcc ccaccccagg aacagatcaa tatgctattg caattcaaag atggtacaga     6180

tgaggaagac tgtcctctcc ctgaagagat tcgacaggat ttgcttgact ttcatcaaga     6240

cctgctggca cactgtggaa ttcagctaga tggagaggag gaggaaccag aggaagagac     6300

caccctgggc agccgcctca tgagcctgtt ggagaaagtg cggctggtga agaagaagga     6360

agagaaacct gaggaggagc ggtcagcaga ggagagcaaa ccccggtccc tgcaggagct     6420

ggtgtcccac atggtggtgc gctgggccca agaggacttc gtgcagagcc ccgagctggt     6480

gcgggccatg ttcagcctcc tgcaccggca gtacgacggg ctgggtgagc tgctgcgtgc     6540

cctgccgcgg gcgtacacca tctcaccgtc ctccgtggaa gacaccatga gcctgctcga     6600

gtgcctcggc cagatccgct cgctgctcat cgtgcagatg ggcccccagg aggagaacct     6660

catgatccag agcatcggga acatcatgaa caacaaagtc ttctaccaac acccgaacct     6720

gatgagggcg ctgggcatgc acgagacggt catggaggtc atggtcaacg tcctcggggg     6780

cggcgagtcc aaggagatcc gcttccccaa gatggtgaca agctgctgcc gcttcctctg     6840

ctatttctgc cgaatcagcc ggcagaacca gcgctccatg tttgaccacc tgagctacct     6900

gctggagaac agtggcatcg gcctgggcat gcagggctcc acgcccctgg acgtggctgc     6960

tgcctccgtc attgacaaca atgagctggc cttggcattg caggagcagg acctggaaaa     7020

ggttgtgtcc tacctggcag gctgtggcct ccagagctgc cccatgcttg tggccaaagg     7080

gtacccagac attggctgga acccctgtgg tggagagcgc tacctggact tcctgcgctt     7140

tgctgtcttc gtcaacggcg agagcgtgga ggagaacgcc aatgtggtgg tgcggctgct     7200

catccggaag cctgagtgct tcggacccgc cctgcggggt gagggtggct cagggctgct     7260

ggctgccatc gaagaggcca tccgcatctc cgaggaccct gcgagggatg gcccaggcat     7320

ccgcagggac cggcggcgcg agcactttgg tgaggaaccg cctgaagaaa accgggtgca     7380

cctgggacac gccatcatgt ccttctatgc cgccttgatc gacctgctcg gacgctgtgc     7440

accagagatg catctaatcc aagccggcaa gggtgaggcc ctgcggatcc gcgccatcct     7500

ccgctccctt gtgcccttgg aggaccttgt gggcatcatc agcctcccac tgcagattcc     7560

caccctgggc aaagatgggg ctctggtgca gccaaagatg tcagcatcct tcgtgccgga     7620

ccacaaggcg tccatggtgc tcttcctgga ccgtgtgtat ggcatcgaga accaggactt     7680

cttgctgcac gtgctggacg tggggttcct gcccgacatg agggcagccg cctcgctgga     7740

cacggccact ttcagcacca ccgagatggc gctggcgctg aaccgctacc tgtgcctggc     7800

cgtgctgccg ctcatcacca agtgtgcgcc gctctttgcg ggcacagaac accgcgccat     7860

catggtggac tctatgctgc ataccgtgta ccgcctgtct cggggtcgtt cgctcaccaa     7920

ggcgcagcgt gacgtcatcg aggactgcct catgtcgctc tgcaggtaca tccgcccgtc     7980

gatgctgcag cacctgttgc gccgcctggt gttcgacgtg cccatcctca acgagttcgc     8040

caagatgcca ctcaagctcc tcaccaacca ctatgagcgc tgttggaagt actactgcct     8100

acccacgggc tgggccaact tcggggtcac ctcagaggag gagctgcacc tcacacggaa     8160

actcttctgg ggcatctttg actctctggc ccataagaaa tacgacccgg agctgtaccg     8220

catggccatg ccttgtctgt gcgccattgc cggggctctg ccccccgact atgtggatgc     8280

ctcatactca tctaaggcag agaaaaaggc cacagtggat gctgaaggca actttgatcc     8340

ccggcctgtg gagaccctca atgtgatcat cccggagaag ctggactcct tcattaacaa     8400

gtttgcggag tacacacacg agaagtgggc cttcgacaag atccagaaca actggtccta     8460

tggagagaac atagacgagg agctgaagac ccaccccatg ctgaggccct acaagacctt     8520

ttcagagaag gacaaagaga tttaccgctg gcccatcaag gagtccctga aggccatgat     8580

tgcctgggaa tggacgatag agaaggccag ggagggtgag gaggagaaga cggaaaagaa     8640

aaaaacgcgg aagatatcac aaagtgccca gacctatgat cctcgagaag gctacaaccc     8700

tcagcccccc gaccttagtg ctgttaccct gtcccgggag ctgcaggcca tggcagaaca     8760

actggcagaa aattaccaca acacgtgggg acggaagaag aagcaggagc tggaagccaa     8820

aggcggtggg acccaccccc tgctggtccc ctacgacacg ctcacggcca aggagaaggc     8880

acgagatcga gagaaggccc aggagctact gaaattcctg cagatgaatg gctacgcggt     8940

tacaagaggc cttaaggaca tggaactgga ctcgtcttcc attgaaaagc ggtttgcctt     9000

tggcttcctg cagcagctgc tgcgctggat ggacatttct caggagttca ttgcccacct     9060

ggaggctgtg gtcagcagtg ggcgagtgga aaagtcccca catgaacagg agattaaatt     9120

ctttgccaag atcctgctcc ctttgatcaa ccagtacttc accaaccact gcctctattt     9180

cttgtccact ccggctaaag tgctgggcag cggtggccac gcctctaaca aggagaagga     9240

aatgatcacc agcctcttct gcaaacttgc tgctctcgtc cgccaccgag tctctctctt     9300

tgggacagac gccccagctg tggtcaactg tcttcacatc ctggcccgct ccctggatgc     9360

caggacagtg atgaagtcag gccctgagat cgtgaaggct ggcctccgct ccttcttcga     9420

gagtgcctcg gaggacatcg agaagatggt ggagaacctg cggctgggca aggtgtcgca     9480

ggcgcgcacc caggtgaaag gcgtgggcca gaacctcacc tacaccactg tggcactgct     9540

gccggtcctc accaccctct tccagcacat cgcccagcac cagttcggag atgacgtcat     9600

cctggacgac gtccaggtct cttgctaccg aacgctgtgc agtatctact ccctgggaac     9660

caccaagaac acttatgtgg aaaagcttcg gccagccctc ggggagtgcc tggcccgtct     9720

ggcagcagcc atgccggtgg cgttcctgga gccgcagctg aacgagtaca acgcctgctc     9780

cgtgtacacc accaagtctc cgcgggagcg ggccatcctg gggctcccca acagtgtgga     9840

ggagatgtgt cccgacatcc cggtgctgga gcggctcatg gcagacattg gggggctggc     9900

cgagtcaggt gcccgctaca cagagatgcc gcatgtcatc gagatcacgc tgcccatgct     9960

atgcagctac ctgccccgat ggtgggagcg cgggcccgag gcaccccctt ccgccctgcc    10020

cgccggcgcc cccccaccct gcacagctgt cacctctgac cacctcaact ccctgctggg    10080

gaatatcctg agaatcatcg tcaacaacct gggcattgac gaggcctcct ggatgaagcg    10140

gctggctgtg ttcgcacagc ccattgtgag ccgtgcacgg ccggagctcc tgcagtccca    10200

cttcatccca actatcgggc ggctgcgcaa gagggcaggg aaggtggtgt ccgaggagga    10260

gcagctgcgc ctggaggcca aggcggaggc ccaggagggc gagctgctgg tgcgggacga    10320

gttctctgtg ctctgccggg acctctacgc cctgtatccg ctgctcatcc gctacgtgga    10380

caacaacagg gcgcagtggc tgacggagcc gaatcccagc gcggaggagc tgttcaggat    10440

ggtgggcgag atcttcatct actggtccaa gtcccacaac ttcaagcgcg aggagcagaa    10500

ctttgtggtc cagaatgaga tcaacaacat gtccttcctg actgctgaca acaaaagcaa    10560

aatggctaag gcgggagata tacagtccgg tggctcggac caggaacgca ccaagaagaa    10620

gcgccggggg gaccggtact ctgtgcagac gtcactgatc gtggccacac tgaagaagat    10680

gctgcccatc ggcctgaata tgtgtgcgcc caccgaccaa gacctcatca cgctggccaa    10740

gacccgttac gccctgaaag acacagatga ggaggtccgg gaatttctgc acaacaacct    10800

tcaccttcag ggaaaggtcg aaggctcccc gtctctgcgc tggcagatgg ctctgtaccg    10860

gggcgtcccg ggtcgcgagg aggacgccga tgaccccgag aaaatcgtgc gcagagtcca    10920

ggaagtgtca gccgtgctct actacctgga ccagaccgag cacccttaca agtctaagaa    10980

ggccgtgtgg cacaagcttt tgtccaaaca gcgccggcgg gcagtcgtgg cctgtttccg    11040

tatgacgccc ctgtacaacc tgcccacgca ccgggcatgt aacatgttcc tggagagcta    11100

caaggctgca tggatcctga ctgaagacca cagttttgag gaccgcatga tagatgacct    11160

ttcaaaagct ggggagcagg aggaggagga ggaagaggtg gaagagaaga agccagaccc    11220

cctgcaccag ttggtcctgc acttcagccg cactgccctg acggaaaaga gcaaactgga    11280

tgaggattac ctgtacatgg cctatgctga tatcatggca aagagctgcc acctggagga    11340

gggaggggag aacggtgaag ctgaagagga ggttgaggtc tcctttgagg agaaacagat    11400

ggagaagcag aggctcttgt accagcaagc acggctgcac acccgggggg cggccgagat    11460

ggtgctgcag atgatcagtg cctgcaaagg agagacaggt gccatggtgt cctccaccct    11520

gaagctgggc atctccatcc tcaatggagg caatgctgag gtccagcaga aaatgctgga    11580

ttatcttaag gacaagaagg aagttggctt cttccagagt atccaggcac tgatgcaaac    11640

atgcagcgtc ctggatctca atgcctttga gagacagaac aaggccgagg ggctgggcat    11700

ggtgaatgag gatggcactg tcatcaatcg ccagaacgga gagaaggtca tggcggatga    11760

tgaattcaca caagacctgt tccgattcct acaattgctc tgtgaggggc acaataatga    11820

tttccagaac tacctacgga cacagacagg gaacacgacc actattaaca tcatcatttg    11880

cactgtggac tacctcctgc ggctgcagga atccatcagc gacttctact ggtactactc    11940

gggcaaggat gtcattgaag agcagggcaa gaggaacttc tccaaagcca tgtcggtggc    12000

taagcaggtg ttcaacagcc tcactgagta catccagggt ccctgcaccg ggaaccagca    12060

gagcctggcg cacagtcgcc tatgggacgc agtggtggga ttcctgcacg tgttcgccca    12120

catgatgatg aagctcgctc aggactcaag ccagatcgag ctgctgaagg agctgctgga    12180

tctgcagaag gacatggtgg tgatgttgct gtcgctacta gaagggaacg tggtgaacgg    12240

catgatcgcc cggcagatgg tggacatgct cgtggaatcc tcatccaatg tggagatgat    12300

cctcaagttc ttcgacatgt tcctgaaact caaggacatt gtgggctctg aagccttcca    12360

ggactacgta acggatcccc gtggcctcat ctccaagaag gacttccaga aggccatgga    12420

cagccagaag cagttcagcg gtccagaaat ccagttcctg ctttcgtgct ccgaagcgga    12480

tgagaacgaa atgatcaact gcgaagagtt cgccaaccgc ttccaggagc cagcacgcga    12540

catcggcttc aacgtggcgg tgctgctgac caacctgtcg gagcatgtgc cgcatgaccc    12600

tcgcctgcac aacttcctgg agctggccga gagcatcctt gagtacttcc gcccctacct    12660

gggccgcatc gagatcatgg gcgcgtcacg ccgcatcgag cgcatctact tcgagatctc    12720

agagaccaac cgcgcccagt gggagatgcc ccaggtgaag gagtccaagc gccagttcat    12780

cttcgacgtg gtgaacgagg gcggcgaggc tgagaagatg gagctcttcg tgagtttctg    12840

cgaggacacc atcttcgaga tgcagatcgc cgcgcagatc tcggagcccg agggcgagcc    12900

ggagaccgac gaggacgagg gcgcgggcgc ggcggaggcg ggcgcggaag gcgcggagga    12960

gggcgcggcg gggctcgagg gcacggcggc cacggcggcg gcgggggcga cggcgcgggt    13020

tgtggcggcc gcaggccggg ccctgcgagg cctcagctac cgcagcctgc ggcggcgcgt    13080

gcggcggctg cggcggctta cggcccgcga ggcggccacc gcagtggcgg cgctgctctg    13140

ggcagcagtg acgcgcgctg gggccgctgg cgcgggggcg gcggcgggcg cgctgggcct    13200

gctctggggc tcgctgttcg gcggcggcct ggtggagggc gccaagaagg tgacggtgac    13260

cgagctcctg gcaggcatgc ccgaccccac cagcgacgag gtgcacggcg agcagccggc    13320

cgggccgggc ggagacgcag acggcgaggg tgccagcgag ggcgctggag acgccgcgga    13380

gggcgctgga gacgaggagg aggcggtgca cgaggccggg ccgggcggtg ccgacggggc    13440

ggtggccgtg accgatgggg gccccttccg gcccgaaggg gctggcggtc tcggggacat    13500

gggggacacg acgcctgcgg aaccgcccac acccgagggc tctcccatcc tcaagaggaa    13560

attgggggtg gatggagtgg aggaggagct cccgccagag ccagagcccg agccggaacc    13620

agagctggag ccggagaaag ccgatgccga gaatggggag aaggaagaag ttcccgagcc    13680

cacaccagag ccccccaaga agcaagcacc tccctcaccc cctccaaaga aggaggaagc    13740

tggaggcgaa ttctggggag aactggaggt gcagagggtg aagttcctga actacctgtc    13800

ccggaacttt tacaccctgc ggttccttgc cctcttcttg gcatttgcca tcaacttcat    13860

cttgctgttt tataaggtct cagactctcc accaggggag gacgacatgg aaggctcagc    13920

tgctggggat gtgtcaggtg caggctctgg tggcagctct ggctggggct tgggggccgg    13980

agaggaggca gagggcgatg aggatgagaa catggtgtac tacttcctgg aggaaagcac    14040

aggctacatg gaacccgccc tgcggtgtct gagcctcctg catacactgg tggcctttct    14100

ctgcatcatt ggctataatt gtctcaaggt gcccctggta atctttaagc gggagaagga    14160

gctggcccgg aagctggagt ttgatggcct gtacatcacg gagcagcctg aggacgatga    14220

cgtgaagggg cagtgggacc gactggtgct caacacgccg tctttcccta gcaactactg    14280

ggacaagttt gtcaagcgca aggtcctgga caaacatggg gacatctacg ggcgggagcg    14340

gattgctgag ctactgggca tggacctggc cacactagag atcacagccc acaatgagcg    14400

caagcccaac ccgccgccag ggctgctgac ctggctcatg tccatcgatg tcaagtacca    14460

gatctggaag ttcggggtca tcttcacaga caactccttc ctgtacctgg gctggtatat    14520

ggtgatgtcc ctcttgggac actacaacaa cttcttcttt gctgcccatc tcctggacat    14580

cgccatgggg gtcaagacgc tgcgcaccat cctgtcctct gtcacccaca atgggaaaca    14640

gctggtgatg accgtgggcc ttctggcggt ggtcgtctac ctgtacaccg tggtggcctt    14700

caacttcttc cgcaagttct acaacaagag cgaggatgag gatgaacctg acatgaagtg    14760

tgatgacatg atgacgtgtt acctgtttca catgtacgtg ggtgtccggg ctggcggagg    14820

cattggggac gagatcgagg accccgcggg tgacgaatac gagctctaca gggtggtctt    14880

cgacatcacc ttcttcttct tcgtcatcgt catcctgttg gccatcatcc agggtctgat    14940

catcgacgct tttggtgagc tccgagacca acaagagcaa gtgaaggagg atatggagac    15000

caagtgcttc atctgtggaa tcggcagtga ctactttgat acgacaccgc atggcttcga    15060

gactcacacg ctggaggagc acaacctggc caattacatg tttttcctga tgtatttgat    15120

aaacaaggat gagacagaac acacgggtca ggagtcttat gtctggaaga tgtaccaaga    15180

gagatgttgg gatttcttcc cagctggtga ttgtttccgt aagcagtatg aggaccagct    15240

tagctgacac acccccagct ggccctccac ccccacctca agtgccttat tctcacagca    15300

agccccttag tccccaagcc cctcccccta aggcagctgg gggagaggtg acctagtact    15360

ggaaaataaa tctgtgctac gccccccagc a                                   15391


<210>  2
<211>  15376
<212>  DNA
<213>  Homo sapiens

<400>  2
tctacctcgc gggtgcctct ggtgtctcca gaggtctccg accccagccc gcccccagcc       60

ctcccgccca gcccgcagcc ccctccctct gttccccgac ctcagaccct gggcttccga      120

cctcgacatc atgggtgacg cagaaggcga agacgaggtc cagttcctgc ggacggacga      180

tgaggtggtc ctgcagtgca gcgctaccgt gctcaaggag cagctcaagc tctgcctggc      240

cgccgagggc ttcggcaacc gcctgtgctt cctggagccc actagcaacg cgcagaatgt      300

gccccccgat ctggccatct gttgcttcgt cctggagcag tccctgtctg tgcgagccct      360

gcaggagatg ctggctaaca cggtggaggc tggcgtggag tcatcccagg gcgggggaca      420

caggacgctc ctgtatggcc atgccatcct gctccggcat gcacacagcc gcatgtatct      480

gagctgcctc accacctccc gctccatgac tgacaagctg gccttcgatg tgggactgca      540

ggaggacgca acaggagagg cttgctggtg gaccatgcac ccagcctcca agcagaggtc      600

tgaaggagaa aaggtccgcg ttggggatga catcatcctt gtcagtgtct cctccgagcg      660

ctacctgcac ctgtcgaccg ccagtgggga gctccaggtt gacgcttcct tcatgcagac      720

actatggaac atgaacccca tctgctcccg ctgcgaagag ggcttcgtga cgggaggtca      780

cgtcctccgc ctctttcatg gacatatgga tgagtgtctg accatttccc ctgctgacag      840

tgatgaccag cgcagacttg tctactatga ggggggagct gtgtgcactc atgcccgctc      900

cctctggagg ctggagccac tgagaatcag ctggagtggg agccacctgc gctggggcca      960

gccactccga gtccggcatg tcactaccgg gcagtaccta gcgctcaccg aggaccaggg     1020

cctggtggtg gttgacgcca gcaaggctca caccaaggct acctccttct gcttccgcat     1080

ctccaaggag aagctggatg tggcccccaa gcgggatgtg gagggcatgg gcccccctga     1140

gatcaagtac ggggagtcac tgtgcttcgt gcagcatgtg gcctcaggac tgtggctcac     1200

ctatgctgct ccagacccca aggccctgcg gctcggcgtg ctcaagaaga aggccatgct     1260

gcaccaggag ggccacatgg acgacgcact gtcgctgacc cgctgccagc aggaggagtc     1320

ccaggccgcc cgcatgatcc acagcaccaa tggcctatac aaccagttca tcaagagcct     1380

ggacagcttc agcgggaagc cacggggctc ggggccaccc gctggcacgg cgctgcccat     1440

cgagggcgtt atcctgagcc tgcaggacct catcatctac ttcgagcctc cctccgagga     1500

cttgcagcac gaggagaagc agagcaagct gcgaagcctg cgcaaccgcc agagcctctt     1560

ccaggaggag gggatgctct ccatggtcct gaattgcata gaccgcctaa atgtctacac     1620

cactgctgcc cactttgctg agtttgcagg ggaggaggca gccgagtcct ggaaagagat     1680

tgtgaatctt ctctatgaac tcctagcttc tctaatccgt ggcaatcgta gcaactgtgc     1740

cctcttctcc acaaacttgg actggctggt cagcaagctg gatcggctgg aggcctcgtc     1800

tggcatcctg gaggtcctgt actgtgtcct cattgagagt ccagaggttc tgaacatcat     1860

ccaggagaat cacatcaagt ccatcatctc cctcctggac aagcatggga ggaaccacaa     1920

ggtcctggac gtgctatgct ccctgtgtgt gtgtaatggt gtggctgtac gctccaacca     1980

agatcttatt actgagaact tgctgcctgg ccgtgagctt ctgctgcaga caaacctcat     2040

caactatgtc accagcatcc gccccaacat ctttgtgggc cgagcggaag gcaccacgca     2100

gtacagcaaa tggtactttg aggtgatggt ggacgaggtg actccatttc tgacagctca     2160

ggccacccac ttgcgggtgg gctgggccct caccgagggc tacaccccct accctggggc     2220

cggcgagggc tggggcggca acggggtcgg cgatgacctc tattcctacg gctttgatgg     2280

actgcatctc tggacaggac acgtggcacg cccagtgact tccccagggc agcacctcct     2340

ggcccctgaa gacgtgatca gctgctgcct ggacctcagc gtgccgtcca tctccttccg     2400

catcaacggc tgccccgtgc agggtgtctt tgagtccttc aacctggacg ggctcttctt     2460

ccctgttgtc agcttctcgg ctggtgtcaa ggtgcggttc ctccttggtg gccgccatgg     2520

tgaattcaag ttcctgcccc cacctggcta tgctccatgc catgaggctg tgctccctcg     2580

agagcgactc catcttgaac ccatcaagga gtatcgacgg gaggggcccc gggggcctca     2640

cctggtgggc cccagtcgct gcctctcaca caccgacttc gtgccctgcc ctgtggacac     2700

tgtccagatt gtcctgccgc cccatctgga gcgcattcgg gagaagctgg cggagaacat     2760

ccacgagctc tgggcgctaa cccgcatcga gcagggctgg acctacggcc cggttcggga     2820

tgacaacaag aggctgcacc cgtgtcttgt ggacttccac agccttccag agcctgagag     2880

gaactacaac ctgcagatgt ctggggagac gctcaagact ctgctggctc tgggctgcca     2940

cgtgggcatg gcggatgaga aggcggagga caacctgaag aagacaaaac tccccaagac     3000

gtatatgatg agcaatgggt acaagccggc tccgctggac ctgagccacg tgcggctgac     3060

gccggcgcag acgacactgg tggaccgtct ggcagaaaat gggcacaacg tgtgggcccg     3120

agaccgcgtg ggccagggct ggagctacag cgcagtgcag gacatcccag cgcgccgaaa     3180

ccctcggctg gtgccctacc gcctgctgga tgaagccacc aagcgcagca accgggacag     3240

cctctgccag gccgtgcgca ccctcctggg ctacggctac aacatcgagc ctcctgacca     3300

ggagcccagt caggtggaga accagtctcg ttgtgaccgg gtgcgcatct tccgggcaga     3360

gaaatcctat acagtgcaga gcggccgctg gtacttcgag tttgaagcag tcaccacagg     3420

cgagatgcgc gtgggctggg cgaggcccga gctgaggcct gatgtagagc tgggagctga     3480

cgagctggcc tatgtcttca atgggcaccg cggccagcgc tggcacttgg gcagtgaacc     3540

atttgggcgc ccctggcagc cgggcgatgt cgttggctgt atgatcgacc tcacagagaa     3600

caccattatc ttcaccctca atggcgaggt cctcatgtct gactcaggct ccgaaacagc     3660

cttccgggag attgagattg gggacggctt cctgcccgtc tgcagcttgg gacctggcca     3720

ggtgggtcat ctgaacctgg gccaggacgt gagctctctg aggttctttg ccatctgtgg     3780

cctccaggaa ggcttcgagc catttgccat caacatgcag cgcccagtca ccacctggtt     3840

cagcaaaggc ctgccccagt ttgagccagt gccccttgaa caccctcact atgaggtatc     3900

ccgagtggac ggcactgtgg acacgccccc ctgcctgcgc ctgacccacc gcacctgggg     3960

ctcccagaac agcctggtgg agatgctttt cctgcggctg agcctcccag tccagttcca     4020

ccagcacttc cgctgcactg caggggccac cccgctggca cctcctggcc tgcagccccc     4080

cgccgaggac gaggcccggg cggcggaacc cgaccctgac tacgaaaacc tgcgccgctc     4140

agctgggggc tggagcgagg cagagaacgg caaagaaggg actgcgaagg agggcgcccc     4200

cgggggcacc ccgcaggcgg ggggagaggc gcagcccgcc agggcggaga atgagaagga     4260

tgccaccacc gagaagaaca agaagagagg cttcttattc aaggccaaga aggtcgccat     4320

gatgacccag ccaccggcca cccccacgct gccccgactc cctcacgacg tggtgcctgc     4380

agacaaccgc gatgaccccg agatcatcct caacaccacc acgtactatt actccgtgag     4440

ggtctttgct ggacaggagc ccagctgcgt gtgggcgggc tgggtcaccc ctgactacca     4500

tcagcacgac atgagcttcg acctcagcaa ggtccgggtc gtgacggtga ccatggggga     4560

tgaacaaggc aacgtccaca gcagcctcaa gtgtagcaac tgctacatgg tgtggggcgg     4620

agactttgtg agtcccgggc agcagggccg gatcagccac acggaccttg tcattgggtg     4680

cctggtggac ttggccactg gcttaatgac ctttacagcc aatggcaaag agagcaacac     4740

ctttttccag gtggaaccca acactaagct atttcctgcc gtcttcgtcc tgcccaccca     4800

ccagaacgtc atccagtttg agctggggaa gcagaagaac atcatgccgt tgtcagccgc     4860

catgttccaa agcgagcgca agaacccggc cccgcagtgc ccaccgcggc tggagatgca     4920

gatgctgatg ccagtgtcct ggagccgcat gcccaaccac ttcctgcagg tggagacgag     4980

gcgtgccggc gagcggctgg gctgggccgt gcagtgccag gagccgctga ccatgatggc     5040

gctgcacatc cccgaggaga accggtgcat ggacatcctg gagctgtcgg agcgcctgga     5100

cctgcagcgc ttccactcgc acaccctgcg cctctaccgc gctgtgtgcg ccctgggcaa     5160

caatcgcgtg gcgcacgctc tgtgcagcca cgtagaccaa gctcagctgc tgcacgccct     5220

ggaggacgcg cacctgccag gcccactgcg cgcaggctac tatgacctcc tcatcagcat     5280

ccacctcgaa agtgcctgcc gcagccgccg ctccatgctc tctgaataca tcgtgcccct     5340

cacgcctgag acccgcgcca tcacgctctt ccctcctgga aggagcacag aaaatggtca     5400

cccccggcat ggcctgccgg gagttggagt caccacttcg ctgaggcccc cgcatcattt     5460

ctcgcccccc tgtttcgtgg ccgctctgcc agctgctggg gcagcagagg ccccggcccg     5520

cctcagccct gccatcccgc tggaggccct gcgggacaag gcactgagga tgctggggga     5580

ggcggtgcgc gacggtgggc agcacgctcg cgaccccgtc gggggctccg tggagttcca     5640

gtttgtgcct gtgctcaagc tcgtgtccac cctgctggtg atgggcatct ttggcgatga     5700

ggatgtgaaa cagatcttga agatgattga gcctgaggtc ttcactgagg aagaagagga     5760

ggaggacgag gaggaagagg gtgaagagga agatgaggag gagaaggagg aggatgagga     5820

ggaaacagca caggaaaagg aagatgagga aaaagaggaa gaggaggcag cagaagggga     5880

gaaagaagaa ggcttggagg aagggctgct ccagatgaag ttgccagagt ctgtgaagtt     5940

acagatgtgc cacctgctgg agtatttctg tgaccaagag ctgcagcacc gtgtggagtc     6000

cctggcagcc tttgcggagc gctatgtgga caagctccag gccaaccagc ggagccgcta     6060

tggcctcctc ataaaagcct tcagcatgac cgcagcagag actgcaagac gtacccgcga     6120

gttccgctcc ccaccccagg aacagatcaa tatgctattg caattcaaag atggtacaga     6180

tgaggaagac tgtcctctcc ctgaagagat tcgacaggat ttgcttgact ttcatcaaga     6240

cctgctggca cactgtggaa ttcagctaga tggagaggag gaggaaccag aggaagagac     6300

caccctgggc agccgcctca tgagcctgtt ggagaaagtg cggctggtga agaagaagga     6360

agagaaacct gaggaggagc ggtcagcaga ggagagcaaa ccccggtccc tgcaggagct     6420

ggtgtcccac atggtggtgc gctgggccca agaggacttc gtgcagagcc ccgagctggt     6480

gcgggccatg ttcagcctcc tgcaccggca gtacgacggg ctgggtgagc tgctgcgtgc     6540

cctgccgcgg gcgtacacca tctcaccgtc ctccgtggaa gacaccatga gcctgctcga     6600

gtgcctcggc cagatccgct cgctgctcat cgtgcagatg ggcccccagg aggagaacct     6660

catgatccag agcatcggga acatcatgaa caacaaagtc ttctaccaac acccgaacct     6720

gatgagggcg ctgggcatgc acgagacggt catggaggtc atggtcaacg tcctcggggg     6780

cggcgagtcc aaggagatcc gcttccccaa gatggtgaca agctgctgcc gcttcctctg     6840

ctatttctgc cgaatcagcc ggcagaacca gcgctccatg tttgaccacc tgagctacct     6900

gctggagaac agtggcatcg gcctgggcat gcagggctcc acgcccctgg acgtggctgc     6960

tgcctccgtc attgacaaca atgagctggc cttggcattg caggagcagg acctggaaaa     7020

ggttgtgtcc tacctggcag gctgtggcct ccagagctgc cccatgcttg tggccaaagg     7080

gtacccagac attggctgga acccctgtgg tggagagcgc tacctggact tcctgcgctt     7140

tgctgtcttc gtcaacggcg agagcgtgga ggagaacgcc aatgtggtgg tgcggctgct     7200

catccggaag cctgagtgct tcggacccgc cctgcggggt gagggtggct cagggctgct     7260

ggctgccatc gaagaggcca tccgcatctc cgaggaccct gcgagggatg gcccaggcat     7320

ccgcagggac cggcggcgcg agcactttgg tgaggaaccg cctgaagaaa accgggtgca     7380

cctgggacac gccatcatgt ccttctatgc cgccttgatc gacctgctcg gacgctgtgc     7440

accagagatg catctaatcc aagccggcaa gggtgaggcc ctgcggatcc gcgccatcct     7500

ccgctccctt gtgcccttgg aggaccttgt gggcatcatc agcctcccac tgcagattcc     7560

caccctgggc aaagatgggg ctctggtgca gccaaagatg tcagcatcct tcgtgccgga     7620

ccacaaggcg tccatggtgc tcttcctgga ccgtgtgtat ggcatcgaga accaggactt     7680

cttgctgcac gtgctggacg tggggttcct gcccgacatg agggcagccg cctcgctgga     7740

cacggccact ttcagcacca ccgagatggc gctggcgctg aaccgctacc tgtgcctggc     7800

cgtgctgccg ctcatcacca agtgtgcgcc gctctttgcg ggcacagaac accgcgccat     7860

catggtggac tctatgctgc ataccgtgta ccgcctgtct cggggtcgtt cgctcaccaa     7920

ggcgcagcgt gacgtcatcg aggactgcct catgtcgctc tgcaggtaca tccgcccgtc     7980

gatgctgcag cacctgttgc gccgcctggt gttcgacgtg cccatcctca acgagttcgc     8040

caagatgcca ctcaagctcc tcaccaacca ctatgagcgc tgttggaagt actactgcct     8100

acccacgggc tgggccaact tcggggtcac ctcagaggag gagctgcacc tcacacggaa     8160

actcttctgg ggcatctttg actctctggc ccataagaaa tacgacccgg agctgtaccg     8220

catggccatg ccttgtctgt gcgccattgc cggggctctg ccccccgact atgtggatgc     8280

ctcatactca tctaaggcag agaaaaaggc cacagtggat gctgaaggca actttgatcc     8340

ccggcctgtg gagaccctca atgtgatcat cccggagaag ctggactcct tcattaacaa     8400

gtttgcggag tacacacacg agaagtgggc cttcgacaag atccagaaca actggtccta     8460

tggagagaac atagacgagg agctgaagac ccaccccatg ctgaggccct acaagacctt     8520

ttcagagaag gacaaagaga tttaccgctg gcccatcaag gagtccctga aggccatgat     8580

tgcctgggaa tggacgatag agaaggccag ggagggtgag gaggagaaga cggaaaagaa     8640

aaaaacgcgg aagatatcac aaagtgccca gacctatgat cctcgagaag gctacaaccc     8700

tcagcccccc gaccttagtg ctgttaccct gtcccgggag ctgcaggcca tggcagaaca     8760

actggcagaa aattaccaca acacgtgggg acggaagaag aagcaggagc tggaagccaa     8820

aggcggtggg acccaccccc tgctggtccc ctacgacacg ctcacggcca aggagaaggc     8880

acgagatcga gagaaggccc aggagctact gaaattcctg cagatgaatg gctacgcggt     8940

tacaagaggc cttaaggaca tggaactgga ctcgtcttcc attgaaaagc ggtttgcctt     9000

tggcttcctg cagcagctgc tgcgctggat ggacatttct caggagttca ttgcccacct     9060

ggaggctgtg gtcagcagtg ggcgagtgga aaagtcccca catgaacagg agattaaatt     9120

ctttgccaag atcctgctcc ctttgatcaa ccagtacttc accaaccact gcctctattt     9180

cttgtccact ccggctaaag tgctgggcag cggtggccac gcctctaaca aggagaagga     9240

aatgatcacc agcctcttct gcaaacttgc tgctctcgtc cgccaccgag tctctctctt     9300

tgggacagac gccccagctg tggtcaactg tcttcacatc ctggcccgct ccctggatgc     9360

caggacagtg atgaagtcag gccctgagat cgtgaaggct ggcctccgct ccttcttcga     9420

gagtgcctcg gaggacatcg agaagatggt ggagaacctg cggctgggca aggtgtcgca     9480

ggcgcgcacc caggtgaaag gcgtgggcca gaacctcacc tacaccactg tggcactgct     9540

gccggtcctc accaccctct tccagcacat cgcccagcac cagttcggag atgacgtcat     9600

cctggacgac gtccaggtct cttgctaccg aacgctgtgc agtatctact ccctgggaac     9660

caccaagaac acttatgtgg aaaagcttcg gccagccctc ggggagtgcc tggcccgtct     9720

ggcagcagcc atgccggtgg cgttcctgga gccgcagctg aacgagtaca acgcctgctc     9780

cgtgtacacc accaagtctc cgcgggagcg ggccatcctg gggctcccca acagtgtgga     9840

ggagatgtgt cccgacatcc cggtgctgga gcggctcatg gcagacattg gggggctggc     9900

cgagtcaggt gcccgctaca cagagatgcc gcatgtcatc gagatcacgc tgcccatgct     9960

atgcagctac ctgccccgat ggtgggagcg cgggcccgag gcaccccctt ccgccctgcc    10020

cgccggcgcc cccccaccct gcacagctgt cacctctgac cacctcaact ccctgctggg    10080

gaatatcctg agaatcatcg tcaacaacct gggcattgac gaggcctcct ggatgaagcg    10140

gctggctgtg ttcgcacagc ccattgtgag ccgtgcacgg ccggagctcc tgcagtccca    10200

cttcatccca actatcgggc ggctgcgcaa gagggcaggg aaggtggtgt ccgaggagga    10260

gcagctgcgc ctggaggcca aggcggaggc ccaggagggc gagctgctgg tgcgggacga    10320

gttctctgtg ctctgccggg acctctacgc cctgtatccg ctgctcatcc gctacgtgga    10380

caacaacagg gcgcagtggc tgacggagcc gaatcccagc gcggaggagc tgttcaggat    10440

ggtgggcgag atcttcatct actggtccaa gtcccacaac ttcaagcgcg aggagcagaa    10500

ctttgtggtc cagaatgaga tcaacaacat gtccttcctg actgctgaca acaaaagcaa    10560

aatggctaag tccggtggct cggaccagga acgcaccaag aagaagcgcc ggggggaccg    10620

gtactctgtg cagacgtcac tgatcgtggc cacactgaag aagatgctgc ccatcggcct    10680

gaatatgtgt gcgcccaccg accaagacct catcacgctg gccaagaccc gttacgccct    10740

gaaagacaca gatgaggagg tccgggaatt tctgcacaac aaccttcacc ttcagggaaa    10800

ggtcgaaggc tccccgtctc tgcgctggca gatggctctg taccggggcg tcccgggtcg    10860

cgaggaggac gccgatgacc ccgagaaaat cgtgcgcaga gtccaggaag tgtcagccgt    10920

gctctactac ctggaccaga ccgagcaccc ttacaagtct aagaaggccg tgtggcacaa    10980

gcttttgtcc aaacagcgcc ggcgggcagt cgtggcctgt ttccgtatga cgcccctgta    11040

caacctgccc acgcaccggg catgtaacat gttcctggag agctacaagg ctgcatggat    11100

cctgactgaa gaccacagtt ttgaggaccg catgatagat gacctttcaa aagctgggga    11160

gcaggaggag gaggaggaag aggtggaaga gaagaagcca gaccccctgc accagttggt    11220

cctgcacttc agccgcactg ccctgacgga aaagagcaaa ctggatgagg attacctgta    11280

catggcctat gctgatatca tggcaaagag ctgccacctg gaggagggag gggagaacgg    11340

tgaagctgaa gaggaggttg aggtctcctt tgaggagaaa cagatggaga agcagaggct    11400

cttgtaccag caagcacggc tgcacacccg gggggcggcc gagatggtgc tgcagatgat    11460

cagtgcctgc aaaggagaga caggtgccat ggtgtcctcc accctgaagc tgggcatctc    11520

catcctcaat ggaggcaatg ctgaggtcca gcagaaaatg ctggattatc ttaaggacaa    11580

gaaggaagtt ggcttcttcc agagtatcca ggcactgatg caaacatgca gcgtcctgga    11640

tctcaatgcc tttgagagac agaacaaggc cgaggggctg ggcatggtga atgaggatgg    11700

cactgtcatc aatcgccaga acggagagaa ggtcatggcg gatgatgaat tcacacaaga    11760

cctgttccga ttcctacaat tgctctgtga ggggcacaat aatgatttcc agaactacct    11820

acggacacag acagggaaca cgaccactat taacatcatc atttgcactg tggactacct    11880

cctgcggctg caggaatcca tcagcgactt ctactggtac tactcgggca aggatgtcat    11940

tgaagagcag ggcaagagga acttctccaa agccatgtcg gtggctaagc aggtgttcaa    12000

cagcctcact gagtacatcc agggtccctg caccgggaac cagcagagcc tggcgcacag    12060

tcgcctatgg gacgcagtgg tgggattcct gcacgtgttc gcccacatga tgatgaagct    12120

cgctcaggac tcaagccaga tcgagctgct gaaggagctg ctggatctgc agaaggacat    12180

ggtggtgatg ttgctgtcgc tactagaagg gaacgtggtg aacggcatga tcgcccggca    12240

gatggtggac atgctcgtgg aatcctcatc caatgtggag atgatcctca agttcttcga    12300

catgttcctg aaactcaagg acattgtggg ctctgaagcc ttccaggact acgtaacgga    12360

tccccgtggc ctcatctcca agaaggactt ccagaaggcc atggacagcc agaagcagtt    12420

cagcggtcca gaaatccagt tcctgctttc gtgctccgaa gcggatgaga acgaaatgat    12480

caactgcgaa gagttcgcca accgcttcca ggagccagca cgcgacatcg gcttcaacgt    12540

ggcggtgctg ctgaccaacc tgtcggagca tgtgccgcat gaccctcgcc tgcacaactt    12600

cctggagctg gccgagagca tccttgagta cttccgcccc tacctgggcc gcatcgagat    12660

catgggcgcg tcacgccgca tcgagcgcat ctacttcgag atctcagaga ccaaccgcgc    12720

ccagtgggag atgccccagg tgaaggagtc caagcgccag ttcatcttcg acgtggtgaa    12780

cgagggcggc gaggctgaga agatggagct cttcgtgagt ttctgcgagg acaccatctt    12840

cgagatgcag atcgccgcgc agatctcgga gcccgagggc gagccggaga ccgacgagga    12900

cgagggcgcg ggcgcggcgg aggcgggcgc ggaaggcgcg gaggagggcg cggcggggct    12960

cgagggcacg gcggccacgg cggcggcggg ggcgacggcg cgggttgtgg cggccgcagg    13020

ccgggccctg cgaggcctca gctaccgcag cctgcggcgg cgcgtgcggc ggctgcggcg    13080

gcttacggcc cgcgaggcgg ccaccgcagt ggcggcgctg ctctgggcag cagtgacgcg    13140

cgctggggcc gctggcgcgg gggcggcggc gggcgcgctg ggcctgctct ggggctcgct    13200

gttcggcggc ggcctggtgg agggcgccaa gaaggtgacg gtgaccgagc tcctggcagg    13260

catgcccgac cccaccagcg acgaggtgca cggcgagcag ccggccgggc cgggcggaga    13320

cgcagacggc gagggtgcca gcgagggcgc tggagacgcc gcggagggcg ctggagacga    13380

ggaggaggcg gtgcacgagg ccgggccggg cggtgccgac ggggcggtgg ccgtgaccga    13440

tgggggcccc ttccggcccg aaggggctgg cggtctcggg gacatggggg acacgacgcc    13500

tgcggaaccg cccacacccg agggctctcc catcctcaag aggaaattgg gggtggatgg    13560

agtggaggag gagctcccgc cagagccaga gcccgagccg gaaccagagc tggagccgga    13620

gaaagccgat gccgagaatg gggagaagga agaagttccc gagcccacac cagagccccc    13680

caagaagcaa gcacctccct caccccctcc aaagaaggag gaagctggag gcgaattctg    13740

gggagaactg gaggtgcaga gggtgaagtt cctgaactac ctgtcccgga acttttacac    13800

cctgcggttc cttgccctct tcttggcatt tgccatcaac ttcatcttgc tgttttataa    13860

ggtctcagac tctccaccag gggaggacga catggaaggc tcagctgctg gggatgtgtc    13920

aggtgcaggc tctggtggca gctctggctg gggcttgggg gccggagagg aggcagaggg    13980

cgatgaggat gagaacatgg tgtactactt cctggaggaa agcacaggct acatggaacc    14040

cgccctgcgg tgtctgagcc tcctgcatac actggtggcc tttctctgca tcattggcta    14100

taattgtctc aaggtgcccc tggtaatctt taagcgggag aaggagctgg cccggaagct    14160

ggagtttgat ggcctgtaca tcacggagca gcctgaggac gatgacgtga aggggcagtg    14220

ggaccgactg gtgctcaaca cgccgtcttt ccctagcaac tactgggaca agtttgtcaa    14280

gcgcaaggtc ctggacaaac atggggacat ctacgggcgg gagcggattg ctgagctact    14340

gggcatggac ctggccacac tagagatcac agcccacaat gagcgcaagc ccaacccgcc    14400

gccagggctg ctgacctggc tcatgtccat cgatgtcaag taccagatct ggaagttcgg    14460

ggtcatcttc acagacaact ccttcctgta cctgggctgg tatatggtga tgtccctctt    14520

gggacactac aacaacttct tctttgctgc ccatctcctg gacatcgcca tgggggtcaa    14580

gacgctgcgc accatcctgt cctctgtcac ccacaatggg aaacagctgg tgatgaccgt    14640

gggccttctg gcggtggtcg tctacctgta caccgtggtg gccttcaact tcttccgcaa    14700

gttctacaac aagagcgagg atgaggatga acctgacatg aagtgtgatg acatgatgac    14760

gtgttacctg tttcacatgt acgtgggtgt ccgggctggc ggaggcattg gggacgagat    14820

cgaggacccc gcgggtgacg aatacgagct ctacagggtg gtcttcgaca tcaccttctt    14880

cttcttcgtc atcgtcatcc tgttggccat catccagggt ctgatcatcg acgcttttgg    14940

tgagctccga gaccaacaag agcaagtgaa ggaggatatg gagaccaagt gcttcatctg    15000

tggaatcggc agtgactact ttgatacgac accgcatggc ttcgagactc acacgctgga    15060

ggagcacaac ctggccaatt acatgttttt cctgatgtat ttgataaaca aggatgagac    15120

agaacacacg ggtcaggagt cttatgtctg gaagatgtac caagagagat gttgggattt    15180

cttcccagct ggtgattgtt tccgtaagca gtatgaggac cagcttagct gacacacccc    15240

cagctggccc tccaccccca cctcaagtgc cttattctca cagcaagccc cttagtcccc    15300

aagcccctcc ccctaaggca gctgggggag aggtgaccta gtactggaaa ataaatctgt    15360

gctacgcccc ccagca                                                    15376


<210>  3
<211>  3208
<212>  DNA
<213>  Homo sapiens

<400>  3
gtcgaggtgc tcatagtgga gccctggctc ccgggcggac ggagccgcac ggtagtagat       60

gggggtgtgg ccgtggcccc cgactctgct cggcggggcc gttcctgctt tgccatccgt      120

gtgggacttc cacgacagtg gaggcacgag agctgggccc catatgctgc ttgcccagct      180

tgggaaagag gaggctgctg caaaggaccg atcggcgggt accgtacaga gtggatttgc      240

agggcagtgg catggagccc ctcttccccg cgccgttctg ggaggttatc tacggcagcc      300

accttcaggg caacctgtcc ctcctgagcc ccaaccacag tctgctgccc ccgcatctgc      360

tgctcaatgc cagccacggc gccttcctgc ccctcgggct caaggtcacc atcgtggggc      420

tctacctggc cgtgtgtgtc ggagggctcc tggggaactg ccttgtcatg tacgtcatcc      480

tcaggcacac caaaatgaag acagccacca atatttacat ctttaacctg gccctggccg      540

acactctggt cctgctgacg ctgcccttcc agggcacgga catcctcctg ggcttctggc      600

cgtttgggaa tgcgctgtgc aagacagtca ttgccattga ctactacaac atgttcacca      660

gcaccttcac cctaactgcc atgagtgtgg atcgctatgt agccatctgc caccccatcc      720

gtgccctcga cgtccgcacg tccagcaaag cccaggctgt caatgtggcc atctgggccc      780

tggcctctgt tgtcggtgtt cccgttgcca tcatgggctc ggcacaggtc gaggatgaag      840

agatcgagtg cctggtggag atccctaccc ctcaggatta ctggggcccg gtgtttgcca      900

tctgcatctt cctcttctcc ttcatcgtcc ccgtgctcgt catctctgtc tgctacagcc      960

tcatgatccg gcggctccgt ggagtccgcc tgctctcggg ctcccgagag aaggaccgga     1020

acctgcggcg catcactcgg ctggtgctgg tggtagtggc tgtgttcgtg ggctgctgga     1080

cgcctgtcca ggtcttcgtg ctggcccaag ggctgggggt tcagccgagc agcgagactg     1140

ccgtggccat tctgcgcttc tgcacggccc tgggctacgt caacagctgc ctcaacccca     1200

tcctctacgc cttcctggat gagaacttca aggcctgctt ccgcaagttc tgctgtgcat     1260

ctgccctgcg ccgggacgtg caggtgtctg accgcgtgcg cagcattgcc aaggacgtgg     1320

ccctggcctg caagacctct gagacggtac cgcggcccgc atgactaggc gtggacctgc     1380

ccatggtgcc tgtcagcccg cagagcccat ctacgcccaa cacagagctc acacaggtca     1440

ctgctctcta ggcggacaca ccctgggccc tgagcatcca gagcctggga tgggcttttc     1500

cctgtgggcc agggatgctc ggtcccagag gaggacctag tgacatcatg ggacaggtca     1560

aagcattagg gccacctcca tggccccaga cagactaaag ctgccctcct ggtgcagggc     1620

cgaggggaca caaggaccta cctggaagca gctgacatgc tggtggacgg ccgtgactgg     1680

agcccgtgcc cctccctccc cgtgcttcat gtgactcttg gcctctctgc tgctgcgttg     1740

gcagaaccct gggtgggcag gcacccggag gaggagcagc agctgtgtca tcctgtgccc     1800

cccatgtgct gtgtgctgtt tgcatggcag ggctccagct gccttcagcc ctgtgacgtc     1860

tcctcagggc agctggacag gcttggcact gcccgggaag tgcagcaggc agcttttctt     1920

tggggtggga cttgccctga gcttggagct gccacctgga ggacttgcct gttccgactc     1980

cacctgtgca gccggggcca ccccaggaga aagtgtccag gtgggggctg gcagtccctg     2040

gctgcagacc ccgagctggc cctgggccag ccgcacctct gaaggttttc tgtgtgctgc     2100

acggtgcagg cctcatccct gactgcagct tgactctggg cccaaccccc atttcccttc     2160

aggagaccag cgagaggccc tggcccattc cctccagcgg tgcaatgaac tatcatgctg     2220

tggaccgtca acccagccct gcttctcagt gtggggcagg tgtctcagga cgaaggcgcc     2280

gcgtgaccac atgggcagct ctgttcacaa agtggaggcc tcgttttcct ggtcttgact     2340

gctctgtttg ggtgggagaa gattctctgg gggtccccac atcctcccaa ggctcccctc     2400

acagcctctc ctttgcttga agccagaggt cagtggccgt gctgtgttgc gggggaagct     2460

gtgtggaagg agaagctggt ggccacagca gagtcctgct ctggggacgc ctgcttcatt     2520

tacaagcctc aagatggctc tgtgtagggc ctgagcttgc tgcccaacgg gaggatggct     2580

tcacagcaga gccagcatga ggggtggggc ctggcagggc ttgcttgagc caaactgcaa     2640

aggctgtggt ggctgtgagg acactgcggg ggttgggggg ggggcgtctg tacctcaggg     2700

gatgccccgc tgtggtcacc cagagaatca cccttcctgg tctacagatg gaagctgcag     2760

gttggtgact ttgcaaatgc acttcctaca gatgaactat taaaagacct gcaacattga     2820

aaaaactcat tttttccacc aaaaccttgg ccaggtaacc taccttaggc acctgcaaag     2880

aacaggaagt gatggctgtc tcgcaacaga gcctgggctg ctcctcctgc tctggggagt     2940

ctaggccgtg gggactgttc tggggaggct catgctgtct ccatgacgtc tgtggcagga     3000

gtccctgagg acgggagctg cctagctaca gttttcttgc caaggcgagg tgttttgtga     3060

atctgtgctg atgtaatgtg caccttcacg tatttatgca tgtggcaagc gttacttcct     3120

gtgcacgtag ccagccctgg gtctgtctct ggggtaatga aaaaggaccc taataaacac     3180

ctgctcactg gctgggtatt cttcgtaa                                        3208


<210>  4
<211>  3359
<212>  DNA
<213>  Homo sapiens

<400>  4
gtcgaggtgc tcatagtgga gccctggctc ccgggcggac ggagccgcac ggtagtagat       60

gggggtgtgg ccgtggcccc cgactctgct cggcggggcc gttcctgctt tgccatccgt      120

gtgggacttc cacgacagtg gaggcacgag agctgggccc catatgctgc ttgcccagct      180

tgggaaagag gaggctgctg caaaggaccg atcggcggct tcgggctgcc ggctcactcg      240

gctgctgcgt ctggtctggc gtctgctgag aagatcctct tctaccctgc tctgcacctg      300

tgctcgactg ccagccggct gagggcgggg gtctccacgg tggtcccagc tcccaaggag      360

gttgcagaag taccgtacag agtggatttg cagggcagtg gcatggagcc cctcttcccc      420

gcgccgttct gggaggttat ctacggcagc caccttcagg gcaacctgtc cctcctgagc      480

cccaaccaca gtctgctgcc cccgcatctg ctgctcaatg ccagccacgg cgccttcctg      540

cccctcgggc tcaaggtcac catcgtgggg ctctacctgg ccgtgtgtgt cggagggctc      600

ctggggaact gccttgtcat gtacgtcatc ctcaggcaca ccaaaatgaa gacagccacc      660

aatatttaca tctttaacct ggccctggcc gacactctgg tcctgctgac gctgcccttc      720

cagggcacgg acatcctcct gggcttctgg ccgtttggga atgcgctgtg caagacagtc      780

attgccattg actactacaa catgttcacc agcaccttca ccctaactgc catgagtgtg      840

gatcgctatg tagccatctg ccaccccatc cgtgccctcg acgtccgcac gtccagcaaa      900

gcccaggctg tcaatgtggc catctgggcc ctggcctctg ttgtcggtgt tcccgttgcc      960

atcatgggct cggcacaggt cgaggatgaa gagatcgagt gcctggtgga gatccctacc     1020

cctcaggatt actggggccc ggtgtttgcc atctgcatct tcctcttctc cttcatcgtc     1080

cccgtgctcg tcatctctgt ctgctacagc ctcatgatcc ggcggctccg tggagtccgc     1140

ctgctctcgg gctcccgaga gaaggaccgg aacctgcggc gcatcactcg gctggtgctg     1200

gtggtagtgg ctgtgttcgt gggctgctgg acgcctgtcc aggtcttcgt gctggcccaa     1260

gggctggggg ttcagccgag cagcgagact gccgtggcca ttctgcgctt ctgcacggcc     1320

ctgggctacg tcaacagctg cctcaacccc atcctctacg ccttcctgga tgagaacttc     1380

aaggcctgct tccgcaagtt ctgctgtgca tctgccctgc gccgggacgt gcaggtgtct     1440

gaccgcgtgc gcagcattgc caaggacgtg gccctggcct gcaagacctc tgagacggta     1500

ccgcggcccg catgactagg cgtggacctg cccatggtgc ctgtcagccc gcagagccca     1560

tctacgccca acacagagct cacacaggtc actgctctct aggcggacac accctgggcc     1620

ctgagcatcc agagcctggg atgggctttt ccctgtgggc cagggatgct cggtcccaga     1680

ggaggaccta gtgacatcat gggacaggtc aaagcattag ggccacctcc atggccccag     1740

acagactaaa gctgccctcc tggtgcaggg ccgaggggac acaaggacct acctggaagc     1800

agctgacatg ctggtggacg gccgtgactg gagcccgtgc ccctccctcc ccgtgcttca     1860

tgtgactctt ggcctctctg ctgctgcgtt ggcagaaccc tgggtgggca ggcacccgga     1920

ggaggagcag cagctgtgtc atcctgtgcc ccccatgtgc tgtgtgctgt ttgcatggca     1980

gggctccagc tgccttcagc cctgtgacgt ctcctcaggg cagctggaca ggcttggcac     2040

tgcccgggaa gtgcagcagg cagcttttct ttggggtggg acttgccctg agcttggagc     2100

tgccacctgg aggacttgcc tgttccgact ccacctgtgc agccggggcc accccaggag     2160

aaagtgtcca ggtgggggct ggcagtccct ggctgcagac cccgagctgg ccctgggcca     2220

gccgcacctc tgaaggtttt ctgtgtgctg cacggtgcag gcctcatccc tgactgcagc     2280

ttgactctgg gcccaacccc catttccctt caggagacca gcgagaggcc ctggcccatt     2340

ccctccagcg gtgcaatgaa ctatcatgct gtggaccgtc aacccagccc tgcttctcag     2400

tgtggggcag gtgtctcagg acgaaggcgc cgcgtgacca catgggcagc tctgttcaca     2460

aagtggaggc ctcgttttcc tggtcttgac tgctctgttt gggtgggaga agattctctg     2520

ggggtcccca catcctccca aggctcccct cacagcctct cctttgcttg aagccagagg     2580

tcagtggccg tgctgtgttg cgggggaagc tgtgtggaag gagaagctgg tggccacagc     2640

agagtcctgc tctggggacg cctgcttcat ttacaagcct caagatggct ctgtgtaggg     2700

cctgagcttg ctgcccaacg ggaggatggc ttcacagcag agccagcatg aggggtgggg     2760

cctggcaggg cttgcttgag ccaaactgca aaggctgtgg tggctgtgag gacactgcgg     2820

gggttggggg gggggcgtct gtacctcagg ggatgccccg ctgtggtcac ccagagaatc     2880

acccttcctg gtctacagat ggaagctgca ggttggtgac tttgcaaatg cacttcctac     2940

agatgaacta ttaaaagacc tgcaacattg aaaaaactca ttttttccac caaaaccttg     3000

gccaggtaac ctaccttagg cacctgcaaa gaacaggaag tgatggctgt ctcgcaacag     3060

agcctgggct gctcctcctg ctctggggag tctaggccgt ggggactgtt ctggggaggc     3120

tcatgctgtc tccatgacgt ctgtggcagg agtccctgag gacgggagct gcctagctac     3180

agttttcttg ccaaggcgag gtgttttgtg aatctgtgct gatgtaatgt gcaccttcac     3240

gtatttatgc atgtggcaag cgttacttcc tgtgcacgta gccagccctg ggtctgtctc     3300

tggggtaatg aaaaaggacc ctaataaaca cctgctcact ggctgggtat tcttcgtaa      3359


<210>  5
<211>  5537
<212>  DNA
<213>  Homo sapiens

<400>  5
gaacccggcg aggaaataca tgcactggct gagaatcgcc cgcgccaggg cgcaacgcca       60

caaggtgtag ggagtgtgcg gggtggggcg aaaggggacc caagagtccc tgtggctcgg      120

agtgccgggc cgtcggttct tcattcctgc cctcggggca gacggagtga ccccggcccc      180

cactccccgc cccgaccatg gtagtgttca atggccttct taagatcaaa atctgcgagg      240

ccgtgagctt gaagcccaca gcctggtcgc tgcgccatgc ggtgggaccc cggccgcaga      300

ctttccttct cgacccctac attgccctca atgtggacga ctcgcgcatc ggccaaacgg      360

ccaccaagca gaagaccaac agcccggcct ggcacgacga gttcgtcacc gatgtgtgca      420

acggacgcaa gatcgagctg gctgtctttc acgatgcccc cataggctac gacgacttcg      480

tggccaactg caccatccag tttgaggagc tgctgcagaa cgggagccgc cacttcgagg      540

actggattga tctggagcca gaaggaagag tgtatgtgat catcgatctc tcagggtcgt      600

cgggtgaagc ccctaaagac aatgaagagc gtgtgttcag ggaacgcatg cggccgagga      660

agcggcaggg ggccgtcagg cgcagggtcc atcaggtcaa cggccacaag ttcatggcca      720

cctatcttcg gcagcccacc tactgctccc attgcagaga cttcatctgg ggtgtcatag      780

gaaagcaggg ataccagtgt caagtctgca cctgcgtggt ccacaagcgg tgccacgagc      840

tcataatcac aaagtgtgct gggttaaaga agcaggagac ccccgaccag gtgggctccc      900

agcggttcag cgtcaacatg ccccacaagt tcggtatcca caactacaag gtccctacct      960

tctgcgatca ctgtgggtcc ctgctctggg gactcttgcg gcagggtttg cagtgtaaag     1020

tctgcaaaat gaatgttcac cgtcgatgtg agaccaacgt ggctcccaac tgtggagtgg     1080

atgccagagg aatcgccaaa gtactggccg acctgggcgt taccccagac aaaatcacca     1140

acagcggcca gagaaggaaa aagctcattg ctggtgccga gtccccgcag cctgcttctg     1200

gaagctcacc atctgaggaa gatcgatcca agtcagcacc cacctcccct tgtgaccagg     1260

aaataaaaga acttgagaac aacattcgga aagccttgtc atttgacaac cgaggagagg     1320

agcaccgggc agcatcgtct cctgatggcc agctgatgag ccccggtgag aatggcgaag     1380

tccggcaagg ccaggccaag cgcctgggcc tggatgagtt caacttcatc aaggtgttgg     1440

gcaaaggcag ctttggcaag gtcatgttgg cagaactcaa gggcaaagat gaagtatatg     1500

ctgtgaaggt cttaaagaag gacgtcatcc ttcaggatga tgacgtggac tgcacaatga     1560

cagagaagag gattttggct ctggcacgga aacacccgta ccttacccaa ctctactgct     1620

gcttccagac caaggaccgc ctctttttcg tcatggaata tgtaaatggt ggagacctca     1680

tgtttcagat tcagcgctcc cgaaaattcg acgagcctcg ttcacggttc tatgctgcag     1740

aggtcacatc ggccctcatg ttcctccacc agcatggagt catctacagg gatttgaaac     1800

tggacaacat ccttctggat gcagaaggtc actgcaagct ggctgacttc gggatgtgca     1860

aggaagggat tctgaatggt gtgacgacca ccacgttctg tgggactcct gactacatag     1920

ctcctgagat cctgcaggag ttggagtatg gcccctccgt ggactggtgg gccctggggg     1980

tgctgatgta cgagatgatg gctggacagc ctccctttga ggccgacaat gaggacgacc     2040

tatttgagtc catcctccat gacgacgtgc tgtacccagt ctggctcagc aaggaggctg     2100

tcagcatctt gaaagctttc atgacgaaga atccccacaa gcgcctgggc tgtgtggcat     2160

cgcagaatgg cgaggacgcc atcaagcagc acccattctt caaagagatt gactgggtgc     2220

tcctggagca gaagaagatc aagccaccct tcaaaccacg cattaaaacc aaaagagacg     2280

tcaataattt tgaccaagac tttacccggg aagagccggt actcaccctt gtggacgaag     2340

caattgtaaa gcagatcaac caggaggaat tcaaaggttt ctcctacttt ggtgaagacc     2400

tgatgccctg agagcccact gcagttggac tttgccgatg ctgcaagaag gggtgcagag     2460

aagactcctg tgttggagac actcagcagg tcttgaacta cttctcctcc tcggagcccc     2520

agtcccatgt ccactgtcta tttattgcat tcccttgccc caggccacct cctccccctc     2580

ccacctggtg accagaaggc gctctcggtt cttgtctcac cagtaatgca gactcattgg     2640

gtcagcaatt agctgtatac actgccgtgt ttggaccatt ggcaagcctg gttccactcc     2700

tcaggggctc ctggcagtga agcaacttca gttcttttac tgcaaagaac agaaaaaaga     2760

aagaaagcaa acaagaagac tccggctctg ctatcggaca cagatcctga tccctcttgc     2820

ttcttttccc tcctgcaccg cagcttgcca tccctgccct tctgtcctgg agaagagact     2880

ggtgcttctc cgcacacacg agggagggcg cccttgaggc atgccctctg agggagggag     2940

accagagatg cagggattgg ccagctgggt tggtttgctc tggaatggct aactcttgcc     3000

tgctttggtt ttagcttttc agcatgccaa agtcatgtaa gtttgtgtct tgtggaagaa     3060

atcctctttg tggaaaaaga aacagggttt tgaactctgt taacatttga aaaatatatt     3120

ttcaaattca ctttctaatt ggccaaaaga gatgagttcc agtctgaata caggtagata     3180

ttaaagggct aataaaaaat gagaaaccgg tcgtccaagg tggatgctgt caatgcccga     3240

gtgacacatg agagctgtat gaattgagag aaaaggcaac aagtagcatt cttcatcatt     3300

caagttctac ctggacacaa aggcgaggac cctggggttc caacaaagct cagctcccag     3360

attctctttc cagtttcatc ctaagttcct agcataaaca ctatttattt tctgcagcag     3420

tgtgttattt ttgcgcactt atacaaaatg gtagtactac tgtgttgtgg tttttaaaca     3480

ttaaacatgt aaagttatat acgaaatatc tgcttttgga ataagcagaa tgaggctaaa     3540

catgggttat acaaagggta tctggaaact gaagagcaac ttgttagaaa actgacaatg     3600

tcgcaagatg tactcagttt tgtttctgtg tgacatgcaa tggcaactca tgtggacact     3660

attgaaggga tgtgacatta cctcctgtag atatgctaac agtgttattc tttcatttcc     3720

aagggttctc tgtggctttg tgtatatgtt tcccagaggt catttgatta cctaatttac     3780

tgaactgatt tagcagggaa tggaatccat tccaactatt gcacgtggat ttcccagctg     3840

cccctaaata tatatacttg tgagtggcaa agtggcacta atgaagcttt tgccttttgt     3900

acatttgaga tttttgtata tagtgtttgc tgcaaggcct gtggaattaa ttcgttgcat     3960

atagaggtat caactgctgc atgttcaggc atattataaa actttagtct atgaaagaat     4020

aattataata atgtccaggt gcaatactct gtaagtctat tggttcaagt taccgagaga     4080

taggtgtgtt cctttatggg ggatgggggg gtgtgttggg gattctttgt attgtttatt     4140

tcattttggt ttattttaaa agatgtaaac atatattaag ctatattaaa tctcacatac     4200

agttcttctg tgctctatta taccctgata gagatggggg agagaaagga atgtttttga     4260

tggtggtttc aaagctcgga cagtaactat cttgagccca ttagagagtc tgtgtccata     4320

tttgcatctg gctggtcata gcctttgtta ctaatgatga cattcagttc tcttttgttt     4380

ttatttttta aaaactcagg tgtaattatt atctgttctt aagataattg caaatattaa     4440

atattatgat atatcaattc atgtgtttgg cataccagtg aatgatgaag aacatgagat     4500

taatttaatt tatcttcggt aacttgacat tctggagaga gactatcttc tggagttgag     4560

tacaagcaca gaaacatctt tacggtggca tcatctcatt ttttaggaag acatgataat     4620

actgcccatc atattcatgt gtaactactg ttctttcttc tgctttcttc accataataa     4680

actttggaca accaagcaag ctctaaccgc aatgccagat ggccttgtcc gagggcctag     4740

tgtttgcacg gcagtgggaa ctgggccttt cctacaggac aactggcaag tttgctggga     4800

agtcaaataa tacattccac ctggcagctg aaggcagcca gtcagtctgt cccagaaagg     4860

gcccttttca gcacccaaag ctgggctggc tgggatgcct ctggctggtg aagttctcac     4920

ataggctgat ttaaatccag caaaggtcta tagaaaaagg cttgcgtgtt cgttgagtaa     4980

tcattgtttc attttcattt ttacgagagt ttgaaaatag acacactgtt aacacttctg     5040

ccagtttttt ctgatctttc cagccccacc ccctttctct ttctctctct ctctcaaaga     5100

aaaaaaaaat gggagtgcaa aaaaaacaaa gccaaaaaat atatgaagga tagctgttct     5160

tctgtgttct ctcattatgg actttgtgaa gtagaaacat aatttttttt cctccaaagg     5220

tgaaaaaaca atgcattctt gctttaaaaa aaaaaaagaa ggctaaaaaa ttacctcttt     5280

ttaaattatg tgcaaaataa ttctggctaa ctgtaaaatg tattcaattt taggattttt     5340

tttttttgta ttgtgatgct ttatttgtac atttttttcc tttctggatg taattttaat     5400

ctcttgccat tcattagtgt tatttcattg taaacgttat tgtgccaaat gtactgtatt     5460

caaaaggatg tgaatgtgta ttgtttcaga acctaataaa tacaatgacg ttaagtctta     5520

aaaaaaaaaa aaaaaaa                                                    5537


<210>  6
<211>  2080
<212>  DNA
<213>  Homo sapiens

<400>  6
atctgaaact gagcagagca gggcgccggg cagggccggc gggccacgtg ataagcccgg       60

aaacagctcc gccccctcgc ttcctgagcc gccacatccc ggcagccctc ctacctgcgc      120

acgtggtgcc gccgctgctg cctcccgctc gccctgaacc cagtgcctgc agccatggct      180

cccggccagc tcgccttatt tagtgtctct gacaaaaccg gccttgtgga atttgcaaga      240

aacctgaccg ctcttggttt gaatctggtc gcttccggag ggactgcaaa agctctcagg      300

gatgctggtc tggcagtcag agatgtctct gagttgacgg gatttcctga aatgttgggg      360

ggacgtgtga aaactttgca tcctgcagtc catgctggaa tcctagctcg taatattcca      420

gaagataatg ctgacatggc cagacttgat ttcaatctta taagagttgt tgcctgcaat      480

ctctatccct ttgtaaagac agtggcttct ccaggtgtaa ctgttgagga ggctgtggag      540

caaattgaca ttggtggagt aaccttactg agagctgcag ccaaaaacca cgctcgagtg      600

acagtggtgt gtgaaccaga ggactatgtg gtggtgtcca cggagatgca gagctccgag      660

agtaaggaca cctccttgga gactagacgc cagttagcct tgaaggcatt cactcatacg      720

gcacaatatg atgaagcaat ttcagattat ttcaggaaac agtacagcaa aggcgtatct      780

cagatgccct tgagatatgg aatgaaccca catcagaccc ctgcccagct gtacacactg      840

cagcccaagc ttcccatcac agttctaaat ggagcccctg gatttataaa cttgtgcgat      900

gctttgaacg cctggcagct ggtgaaggaa ctcaaggagg ctttaggtat tccagccgct      960

gcctctttca aacatgtcag cccagcaggt gctgctgttg gaattccact cagtgaagat     1020

gaggccaaag tctgcatggt ttatgatctc tataaaaccc tcacacccat ctcagcggca     1080

tatgcaagag caagaggggc tgataggatg tcttcatttg gtgattttgt tgcattgtcc     1140

gatgtttgtg atgtaccaac tgcaaaaatt atttccagag aagtatctga tggtataatt     1200

gccccaggat atgaagaaga agccttgaca atactttcca aaaagaaaaa tggaaactat     1260

tgtgtccttc agatggacca atcttacaaa ccagatgaaa atgaagttcg aactctcttt     1320

ggtcttcatt taagccagaa gagaaataat ggtgtcgtcg acaagtcatt atttagcaat     1380

gttgttacca aaaataaaga tttgccagag tctgccctcc gagacctcat cgtagccacc     1440

attgctgtca agtacactca gtctaactct gtgtgctacg ccaagaacgg gcaggttatc     1500

ggcattggag caggacagca gtctcgtata cactgcactc gccttgcagg agataaggca     1560

aactattggt ggcttagaca ccatccacaa gtgctttcga tgaagtttaa aacaggagtg     1620

aagagagcag aaatctccaa tgccatcgat caatatgtga ctggaaccat tggcgaggat     1680

gaagatttga taaagtggaa ggcactgttt gaggaagtcc ctgagttact cactgaggca     1740

gagaagaagg aatgggttga gaaactgact gaagtttcta tcagctctga tgccttcttc     1800

cctttccgag ataacgtaga cagagctaaa aggagtggtg tggcgtacat tgcggctccc     1860

tccggttctg ctgctgacaa agttgtgatt gaggcctgcg acgaactggg aatcatcctc     1920

gctcatacga accttcggct cttccaccac tgattttacc acacactgtt ttttggcttg     1980

cttatgtgta ggtgaacagt cacgcctgaa actttgagga taacttttta aaaaaataaa     2040

acagtatctc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           2080


<210>  7
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  7
gagtatctgg atgtcttgga ttttcttccc attctgttct gttctgttct cctaatacca       60

tctcgttact agacgtaggc attggacgtg acaatcaact gcatttgaac tgagaagaag      120

aaatattaaa gacacagtct tcagaagaaa tggctcaaag gcagcctcac tcacctaatc      180

agactttaat ttcaatcaca aatgacacag aatcatcaag ctctgtggtt tctaacgata      240

acacaaataa aggatggagc ggggacaact ctccaggaat agaagcattg tgtgccatct      300

atattactta tgctgtgatc atttcagtgg gcatccttgg aaatgctatt ctcatcaaag      360

tctttttcaa gaccaaatcc atgcaaacag ttccaaatat tttcatcacc agcctggctt      420

ttggagatct tttacttctg ctaacttgtg tgccagtgga tgcaactcac taccttgcag      480

aaggatggct gttcggaaga attggttgta aggtgctctc tttcatccgg ctcacttctg      540

ttggtgtgtc agtgttcaca ttaacaattc tcagcgctga cagatacaag gcagttgtga      600

agccacttga gcgacagccc tccaatgcca tcctgaagac ttgtgtaaaa gctggctgcg      660

tctggatcgt gtctatgata tttgctctac ctgaggctat attttcaaat gtatacactt      720

ttcgagatcc caataaaaat atgacatttg aatcatgtac ctcttatcct gtctctaaga      780

agctcttgca agaaatacat tctctgctgt gcttcttagt gttctacatt attccactct      840

ctattatctc tgtctactat tccttgattg ctaggaccct ttacaaaagc accctgaaca      900

tacctactga ggaacaaagc catgcccgta agcagattga atcccgaaag agaattgcca      960

gaacggtatt ggtgttggtg gctctgtttg ccctctgctg gttgccaaat cacctcctgt     1020

acctctacca ttcattcact tctcaaacct atgtagaccc ctctgccatg catttcattt     1080

tcaccatttt ctctcgggtt ttggctttca gcaattcttg cgtaaacccc tttgctctct     1140

actggctgag caaaagcttc cagaagcatt ttaaagctca gttgttctgt tgcaaggcgg     1200

agcggcctga gcctcctgtt gctgacacct ctcttaccac cctggctgtg atgggaacgg     1260

tcccgggcac tgggagcata cagatgtctg aaattagtgt gacctcgttc actgggtgta     1320

gtgtgaagca ggcagaggac agattctagc ttttcaagga aaaatgctgc ttctcctccc     1380

agcgtgtgta tccgactcta agctgtgtgc agg                                  1413


<210>  8
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  8
gcgtgggcag ggggcgggcc cgggagttgg aacagagggc acagacggcc cctcctcgga       60

ggggagggac cggagccggg gcctttttct ttaagactcg cagcactgga tcccagaact      120

tagtctgcgc ggcggcattg acactagctg ggctcctcgg ggcgcgcccc aggtggtccg      180

aagcccggtc cgccctccac gcaggtgccc cgcgctcccc gctcagccat gtcgtcctgc      240

agccgcgtgg cgctggtgac cggggccaac aggggcatcg gcttggccat cgcgcgcgaa      300

ctgtgccgac agttctctgg ggatgtggtg ctcaccgcgc gggacgtggc gcggggccag      360

gcggccgtgc agcagctgca ggcggagggc ctgagcccgc gcttccacca actggacatc      420

gacgacttgc agagcatccg cgccctgcgc gacttcctgc gcaaggagta cggggggctc      480

aacgtactgg tcaacaacgc ggccgtcgcc ttcaagagtg atgatccaat gccctttgac      540

attaaagctg agatgacact gaagacaaat ttttttgcca ctagaaacat gtgcaacgag      600

ttactgccga taatgaaacc tcatgggaga gtggtgaata tcagtagttt gcagtgttta      660

agggcttttg aaaactgcag tgaagatctg caggaaaggt tccacagtga gacactcaca      720

gaaggagacc tggtggatct catgaaaaag tttgtggagg acacaaaaaa tgaggtgcat      780

gagagggaag gctggcccaa ctcaccttat ggggtgtcca agttgggggt cacggtctta      840

tcgaggatcc tggccaggcg tctggatgag aagaggaaag ctgacaggat tctggtgaat      900

gcgtgctgcc caggaccagt gaagacagac atggatggga aagacagcat caggactgtg      960

gaggaggggg ctgagacccc tgtctacttg gccctcttgc ctccagatgc cactgagcca     1020

caaggccagt tggtccatga caaagttgtg caaaactggt aaacgtctgc ttcggagctt     1080

gctgcttaat aaatgttggt ggaatgaatg aaaaaaaaaa aaaaaaaa                  1128


<210>  9
<211>  3539
<212>  DNA
<213>  Homo sapiens

<400>  9
ccggaaccgg ccttggaaca actgtggaac ctgaggccgc ttgccctccc gccccatgga       60

gcggcccccg gggctgcggc cgggcgcggg cgggccctgg gagatgcggg agcggctggg      120

caccggcggc ttcgggaacg tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc      180

aattaagtct tgtcgcctag agctaagtac caaaaacaga gaacgatggt gccatgaaat      240

ccagattatg aagaagttga accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga      300

attgaatatt ttgattcatg atgtgcctct tctagcaatg gaatactgtt ctggaggaga      360

tctccgaaag ctgctcaaca aaccagaaaa ttgttgtgga cttaaagaaa gccagatact      420

ttctttacta agtgatatag ggtctgggat tcgatatttg catgaaaaca aaattataca      480

tcgagatcta aaacctgaaa acatagttct tcaggatgtt ggtggaaaga taatacataa      540

aataattgat ctgggatatg ccaaagatgt tgatcaagga agtctgtgta catcttttgt      600

gggaacactg cagtatctgg ccccagagct ctttgagaat aagccttaca cagccactgt      660

tgattattgg agctttggga ccatggtatt tgaatgtatt gctggatata ggcctttttt      720

gcatcatctg cagccattta cctggcatga gaagattaag aagaaggatc caaagtgtat      780

atttgcatgt gaagagatgt caggagaagt tcggtttagt agccatttac ctcaaccaaa      840

tagcctttgt agtttagtag tagaacccat ggaaaactgg ctacagttga tgttgaattg      900

ggaccctcag cagagaggag gacctgttga ccttactttg aagcagccaa gatgttttgt      960

attaatggat cacattttga atttgaagat agtacacatc ctaaatatga cttctgcaaa     1020

gataatttct tttctgttac cacctgatga aagtcttcat tcactacagt ctcgtattga     1080

gcgtgaaact ggaataaata ctggttctca agaacttctt tcagagacag gaatttctct     1140

ggatcctcgg aaaccagcct ctcaatgtgt tctagatgga gttagaggct gtgatagcta     1200

tatggtttat ttgtttgata aaagtaaaac tgtatatgaa gggccatttg cttccagaag     1260

tttatctgat tgtgtaaatt atattgtaca ggacagcaaa atacagcttc caattataca     1320

gctgcgtaaa gtgtgggctg aagcagtgca ctatgtgtct ggactaaaag aagactatag     1380

caggctcttt cagggacaaa gggcagcaat gttaagtctt cttagatata atgctaactt     1440

aacaaaaatg aagaacactt tgatctcagc atcacaacaa ctgaaagcta aattggagtt     1500

ttttcacaaa agcattcagc ttgacttgga gagatacagc gagcagatga cgtatgggat     1560

atcttcagaa aaaatgctaa aagcatggaa agaaatggaa gaaaaggcca tccactatgc     1620

tgaggttggt gtcattggat acctggagga tcagattatg tctttgcatg ctgaaatcat     1680

ggagctacag aagagcccct atggaagacg tcagggagac ttgatggaat ctctggaaca     1740

gcgtgccatt gatctatata agcagttaaa acacagacct tcagatcact cctacagtga     1800

cagcacagag atggtgaaaa tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa     1860

ggagctgttt ggtcatttga gcaagttgtt gggctgtaag cagaagatta ttgatctact     1920

ccctaaggtg gaagtggccc tcagtaatat caaagaagct gacaatactg tcatgttcat     1980

gcagggaaaa aggcagaaag aaatatggca tctccttaaa attgcctgta cacagagttc     2040

tgcccggtcc cttgtaggat ccagtctaga aggtgcagta acccctcaga catcagcatg     2100

gctgcccccg acttcagcag aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga     2160

tggggagact tcagcacaaa tgatagaaga aaatttgaac tgccttggcc atttaagcac     2220

tattattcat gaggcaaatg aggaacaggg caatagtatg atgaatcttg attggagttg     2280

gttaacagaa tgagttgtca cttgttcact gtccccaaac ctatggaagt tgttgctata     2340

catgttggaa atgtgttttt cccccatgaa accattcttc agacatcagt caatggaaga     2400

aatggctatg aacagaaact acatttctac tatgatcaga agaacatgat tttacaagta     2460

taacagtttt gagtaattca agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac     2520

ttgtttgaat atttgtttta ataccacagc tatttagaag catcatcacg acacatttgc     2580

cttcagtctt ggtaaaacat tacttattta actgattaaa aataccttct atgtattagt     2640

gtcaactttt aacttttggg cgtaagacca aatgtagttt tgtatacaga gaagaaaacc     2700

tcaagtaata ggcattttaa gtaaaagtct acctgtgttt ttttctaaaa aggctgctca     2760

caagttctat ttcttgaaga ataaattcta cctccttgtg ttgcactgaa caggttctct     2820

tcctggcatc ataaggagtt ggtgtaatca ttttaaattc cactgaaaat ttaacagtat     2880

ccccttctca tcgaagggat tgtgtatctg tgcttctaat attagttggc tttcataaat     2940

catgttgttg tgtgtatatg tatttaagat gtacatttaa taatatcaaa gagaagatgc     3000

ctgttaattt ataatgtatt tgaaaattac atgttttttc atttgtaaaa atgagtcatt     3060

tgtttaaaca atctttcatg tcttgtcata caaatttata aaggtctgca ctcctttatc     3120

tgtaattgta attccaaaat ccaaaaagct ctgaaaacaa ggtttccata agcttggtga     3180

caaaattcat ttgcttgcaa tctaatctga actgaccttg aatcttttta tcccatttag     3240

tgtgaatatt cctttatttt gctgcttgat gatgagaggg agggctgctg ccacagactg     3300

tggtgagggc tggttaatgt agtatggtat atgcacaaaa ctacttttct aaaatctaaa     3360

atttcataat tctgaaacaa cttgccccaa gggtttcaga gaaaggactg tggacctcta     3420

tcatctgcta agtaatttag aagatattat ttgtcttaaa aaatgtgaaa tgcttttata     3480

ttctaatagt ttttcacttt gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa      3539


<210>  10
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  10
ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag       60

gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg      120

tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg      180

ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg      240

ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct      300

cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca      360

acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg      420

gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc      480

acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct      540

ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact      600

ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca      660

tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac      720

ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc      780

tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct      840

gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta      900

tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta      960

ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg     1020

ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc     1080

tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat     1140

acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc     1200

ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct     1260

ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc     1320

atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt     1380

ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag     1440

acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt     1500

tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa     1560

agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc     1620

tgtcctatat accctctaga aacagaaagc aatttttagg cagctatggt caaattgaga     1680

aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa     1740

atgggcttta aattt                                                      1755


<210>  11
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcagtgcag ctgtgggaac ctctccacgc gcacgaactc agccaacgat ttctgataga       60

tttttgggag tttgaccaga gatgcaaggg gtgaaggagc gcttcctacc gttagggaac      120

tctggggaca gagcgccccg gccgcctgat ggccgaggca gggtgcgacc caggacccag      180

gacggcgtcg ggaaccatac catggcccgg atccccaaga ccctaaagtt cgtcgtcgtc      240

atcgtcgcgg tcctgctgcc agtcctagct tactctgcca ccactgcccg gcaggaggaa      300

gttccccagc agacagtggc cccacagcaa cagaggcaca gcttcaaggg ggaggagtgt      360

ccagcaggat ctcatagatc agaacatact ggagcctgta acccgtgcac agagggtgtg      420

gattacacca acgcttccaa caatgaacct tcttgcttcc catgtacagt ttgtaaatca      480

gatcaaaaac ataaaagttc ctgcaccatg accagagaca cagtgtgtca gtgtaaagaa      540

ggcaccttcc ggaatgaaaa ctccccagag atgtgccgga agtgtagcag gtgccctagt      600

ggggaagtcc aagtcagtaa ttgtacgtcc tgggatgata tccagtgtgt tgaagaattt      660

ggtgccaatg ccactgtgga aaccccagct gctgaagaga caatgaacac cagcccgggg      720

actcctgccc cagctgctga agagacaatg aacaccagcc cagggactcc tgccccagct      780

gctgaagaga caatgaccac cagcccgggg actcctgccc cagctgctga agagacaatg      840

accaccagcc cggggactcc tgccccagct gctgaagaga caatgaccac cagcccgggg      900

actcctgcct cttctcatta cctctcatgc accatcgtag ggatcatagt tctaattgtg      960

cttctgattg tgtttgtttg aaagacttca ctgtggaaga aattccttcc ttacctgaaa     1020

ggttcaggta ggcgctggct gagggcgggg ggcgctggac actctctgcc ctgcctccct     1080

ctgctgtgtt cccacagaca gaaacgcctg cccctgcccc aagtcctggt gtctccagcc     1140

tggctctatc ttcctccttg tgatcgtccc atccccacat cccgtgcacc ccccaggacc     1200

ctggtctcat cagtccctct cctggagctg ggggtccaca catctcccag ccaagtccaa     1260

gagggcaggg ccagttcctc ccatcttcag gcccagccag gcagggggca gtcggctcct     1320

caactgggtg acaagggtga ggatgagaag tggtcacggg atttattcag ccttggtcag     1380

agcagaaaaa aaaaaaaaaa aaaa                                            1404


<210>  12
<211>  3213
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtgcttca gtttcataat gcctcctgct atggcagaca tccttgacat ctgggcggtg       60

gattcacaga tagcatctga tggctccata cctgtggatt tccttttgcc cactgggatt      120

tatatccagt tggaggtacc tcgggaagct accatttctt atattaagca gatgttatgg      180

aagcaagttc acaattaccc aatgttcaac ctccttatgg atattgactc ctatatgttt      240

gcatgtgtga atcagactgc tgtatatgag gagcttgaag atgaaacacg aagactctgt      300

gatgtcagac cttttcttcc agttctcaaa ttagtgacaa gaagttgtga cccaggggaa      360

aaattagact caaaaattgg agtccttata ggaaaaggtc tgcatgaatt tgattccttg      420

aaggatcctg aagtaaatga atttcgaaga aaaatgcgca aattcagcga ggaaaaaatc      480

ctgtcacttg tgggattgtc ttggatggac tggctaaaac aaacatatcc accagagcat      540

gaaccatcca tccctgaaaa cttagaagat aaactttatg ggggaaagct catcgtagct      600

gttcattttg aaaactgcca ggacgtgttt agctttcaag tgtctcctaa tatgaatcct      660

atcaaagtaa atgaattggc aatccaaaaa cgtttgacta ttcatgggaa ggaagatgaa      720

gttagcccct atgattatgt gttgcaagtc agcgggagag tagaatatgt ttttggtgat      780

catccactaa ttcagttcca gtatatccgg aactgtgtga tgaacagagc cctgccccat      840

tttatacttg tggaatgctg caagatcaag aaaatgtatg aacaagaaat gattgccata      900

gaggctgcca taaatcgaaa ttcatctaat cttcctcttc cattaccacc aaagaaaaca      960

cgaattattt ctcatgtttg ggaaaataac aaccctttcc aaattgtctt ggttaaggga     1020

aataaactta acacagagga aactgtaaaa gttcatgtca gggctggtct ttttcatggt     1080

actgagctcc tgtgtaaaac catcgtaagc tcagaggtat cagggaaaaa tgatcatatt     1140

tggaatgaac cactggaatt tgatattaat atttgtgact taccaagaat ggctcgatta     1200

tgttttgctg tttatgcagt tttggataaa gtaaaaacga agaaatcaac gaaaactatt     1260

aatccctcta aatatcagac catcaggaaa gctggaaaag tgcattatcc tgtagcgtgg     1320

gtaaatacga tggtttttga ctttaaagga caattgagaa ctggagacat aatattacac     1380

agctggtctt catttcctga tgaactcgaa gaaatgttga atccaatggg aactgttcaa     1440

acaaatccat atactgaaaa tgcaacagct ttgcatgtta aatttccaga gaataaaaaa     1500

caaccttatt attaccctcc cttcgataag attattgaaa aggcagctga gattgcaagc     1560

agtgatagtg ctaatgtgtc aagtcgaggt ggaaaaaagt ttcttcctgt attgaaagaa     1620

atcttggaca gggatccctt gtctcaactg tgtgaaaatg aaatggatct tatttggact     1680

ttgcgacaag actgccgaga gattttccca caatcactgc caaaattact gctgtcaatc     1740

aagtggaata aacttgagga tgttgctcag cttcaggcgc tgcttcagat ttggcctaaa     1800

ctgccccccc gggaggccct agagcttctg gatttcaact atccagacca gtacgttcga     1860

gaatatgctg taggctgcct gcgacagatg agtgatgaag aactttctca atatctttta     1920

caactggtgc aagtgttaaa atatgagcct tttcttgatt gtgccctctc tagattccta     1980

ttagaaagag cacttggtaa tcggaggata gggcagtttc tattttggca tcttaggtca     2040

gaagtgcaca ttcctgctgt ctcagtacaa tttggtgtca tccttgaagc atactgccgg     2100

ggaagtgtgg ggcacatgaa agtgctttct aagcaggttg aagcactcaa taagttaaaa     2160

actttaaata gtttaatcaa actgaatgcc gtgaagttaa acagagccaa agggaaggag     2220

gccatgcata cctgtttaaa acagagtgct taccgggaag ccctctctga cctgcagtca     2280

cccctgaacc catgtgttat cctctcagaa ctctatgttg aaaagtgcaa atacatggat     2340

tccaaaatga agcctttgtg gctggtatac aataacaagg tatttggtga ggattcagtt     2400

ggagtgattt ttaaaaatgg tgatgattta cgacaggata tgttgacact ccaaatgttg     2460

cgcttgatgg atttactctg gaaagaagct ggtttggatc ttcggatgtt gccttatggc     2520

tgtttagcaa caggagatcg ctctggcctc attgaagttg tgagcacctc tgaaacaatt     2580

gctgacattc agctgaacag tagcaatgtg gctgctgcag cagccttcaa caaagatgcc     2640

cttctgaact ggcttaaaga atacaactct ggggatgacc tggaccgagc cattgaggaa     2700

tttacactgt cctgtgctgg ctactgtgta gcttcttatg tccttgggat tggtgacaga     2760

catagtgaca acatcatggt caaaaaaact ggccagctct tccacattga ctttggacat     2820

attcttggaa atttcaaatc taagtttggc attaaaaggg agcgagtgcc ttttattctt     2880

acctatgatt tcatccatgt cattcaacaa ggaaaaacag gaaatacaga aaagtttggc     2940

cggttccgcc agtgttgtga ggatgcatat ctgattttac gacggcatgg gaatctcttc     3000

atcactctct ttgcgctgat gttgactgca gggcttcctg aactcacatc agtcaaagat     3060

atacagtatc ttaaggactc tcttgcatta gggaagagtg aagaagaagc actcaaacag     3120

tttaagcaaa aatttgatga ggcgctcagg gaaagctgga ctactaaagt gaactggatg     3180

gcccacacag ttcggaaaga ctacagatct taa                                  3213


<210>  13
<211>  1746
<212>  DNA
<213>  Homo sapiens

<400>  13
cgttgtctca cccgggaagg gaaagcagcc agcagccctc cagccctctt gtgctttccc       60

tgggagtgcg ccccgtgctc agccatggtg gacatggggg ccctggacaa cctgatcgcc      120

aacaccgcct acctgcaggc ccggaagccc tcggactgcg acagcaaaga gctgcagcgg      180

cggcggcgta gcctggccct gcccgggctg cagggctgcg cggagctccg ccagaagctg      240

tccctgaact tccacagcct gtgtgagcag cagcccatcg gtcgccgcct cttccgtgac      300

ttcctagcca cagtgcccac gttccgcaag gcggcaacct tcctagagga cgtgcagaac      360

tgggagctgg ccgaggaggg acccaccaaa gacagcgcgc tgcaggggct ggtggccact      420

tgtgcgagtg cccctgcccc ggggaacccg caacccttcc tcagccaggc cgtggccacc      480

aagtgccaag cagccaccac tgaggaagag cgagtggctg cagtgacgct ggccaaggct      540

gaggccatgg ctttcttgca agagcagccc tttaaggatt tcgtgaccag cgccttctac      600

gacaagtttc tgcagtggaa actcttcgag atgcaaccag tgtcagacaa gtacttcact      660

gagttcagag tgctggggaa aggtggtttt ggggaggtat gtgccgtcca ggtgaaaaac      720

actgggaaga tgtatgcctg taagaaactg gacaagaagc ggctgaagaa gaaaggtggc      780

gagaagatgg ctctcttgga aaaggaaatc ttggagaagg tcagcagccc tttcattgtc      840

tctctggcct atgcctttga gagcaagacc catctctgcc ttgtcatgag cctgatgaat      900

gggggagacc tcaagttcca catctacaac gtgggcacgc gtggcctgga catgagccgg      960

gtgatctttt actcggccca gatagcctgt gggatgctgc acctccatga actcggcatc     1020

gtctatcggg acatgaagcc tgagaatgtg cttctggatg acctcggcaa ctgcaggtta     1080

tctgacctgg ggctggccgt ggagatgaag ggtggcaagc ccatcaccca gagggctgga     1140

accaatggtt acatggctcc tgagatccta atggaaaagg taagttattc ctatcctgtg     1200

gactggtttg ccatgggatg cagcatttat gaaatggttg ctggacgaac accattcaaa     1260

gattacaagg aaaaggtcag taaagaggat ctgaagcaaa gaactctgca agacgaggtc     1320

aaattccagc atgataactt cacagaggaa gcaaaagata tttgcaggct cttcttggct     1380

aagaaaccag agcaacgctt aggaagcaga gaaaagtctg atgatcccag gaaacatcat     1440

ttctttaaaa cgatcaactt tcctcgcctg gaagctggcc taattgaacc cccatttgtg     1500

ccagaccctt cagtggttta tgccaaagac atcgctgaaa ttgatgattt ctctgaggtt     1560

cggggggtgg aatttgatga caaagataag cagttcttca aaaactttgc gacaggtgct     1620

gttcctatag catggcagga agaaattata gaaacgggac tgtttgagga actgaatgac     1680

cccaacagac ctacgggttg tgaggagggt aattcatcca agtctggcgt gtgtttgtta     1740

ttgtaa                                                                1746


<210>  14
<211>  3133
<212>  DNA
<213>  Homo sapiens

<400>  14
ccgctgaggc cgcggcgccc gccagcctgt cccgcgccat ggccccgcgc gcccggcggc       60

gccgcccgct gttcgcgctg ctgctgctct gcgcgctgct cgcccggctg caggtggctt      120

tgcagatcgc tcctccatgt accagtgaga agcattatga gcatctggga cggtgctgta      180

acaaatgtga accaggaaag tacatgtctt ctaaatgcac tactacctct gacagtgtat      240

gtctgccctg tggcccggat gaatacttgg atagctggaa tgaagaagat aaatgcttgc      300

tgcataaagt ttgtgataca ggcaaggccc tggtggccgt ggtcgccggc aacagcacga      360

ccccccggcg ctgcgcgtgc acggctgggt accactggag ccaggactgc gagtgctgcc      420

gccgcaacac cgagtgcgcg ccgggcctgg gcgcccagca cccgttgcag ctcaacaagg      480

acacagtgtg caaaccttgc cttgcaggct acttctctga tgccttttcc tccacggaca      540

aatgcagacc ctggaccaac tgtaccttcc ttggaaagag agtagaacat catgggacag      600

agaaatccga tgcggtttgc agttcttctc tgccagctag aaaaccacca aatgaacccc      660

atgtttactt gcccggttta ataattctgc ttctcttcgc gtctgtggcc ctggtggctg      720

ccatcatctt tggcgtttgc tataggaaaa aagggaaagc actcacagct aatttgtggc      780

actggatcaa tgaggcttgt ggccgcctaa gtggagataa ggagtcctca ggtgacagtt      840

gtgtcagtac acacacggca aactttggtc agcagggagc atgtgaaggt gtcttactgc      900

tgactctgga ggagaagaca tttccagaag atatgtgcta cccagatcaa ggtggtgtct      960

gtcagggcac atgtgtagga ggtggtccct acgcacaagg cgaagatgcc aggatgctct     1020

cattggtcag caagaccgag atagaggaag acagcttcag acagatgccc acagaagatg     1080

aatacatgga caggccctcc cagcccacag accagttact gttcctcact gagcctggaa     1140

gcaaatccac acctcctttc tctgaacccc tggaggtggg ggagaatgac agtttaagcc     1200

agtgcttcac ggggacacag agcacagtgg gttcagaaag ctgcaactgc actgagcccc     1260

tgtgcaggac tgattggact cccatgtcct ctgaaaacta cttgcaaaaa gaggtggaca     1320

gtggccattg cccgcactgg gcagccagcc ccagccccaa ctgggcagat gtctgcacag     1380

gctgccggaa ccctcctggg gaggactgtg aacccctcgt gggttcccca aaacgtggac     1440

ccttgcccca gtgcgcctat ggcatgggcc ttccccctga agaagaagcc agcaggacgg     1500

aggccagaga ccagcccgag gatggggctg atgggaggct cccaagctca gcgagggcag     1560

gtgccgggtc tggaagctcc cctggtggcc agtcccctgc atctggaaat gtgactggaa     1620

acagtaactc cacgttcatc tccagcgggc aggtgatgaa cttcaagggc gacatcatcg     1680

tggtctacgt cagccagacc tcgcaggagg gcgcggcggc ggctgcggag cccatgggcc     1740

gcccggtgca ggaggagacc ctggcgcgcc gagactcctt cgcggggaac ggcccgcgct     1800

tcccggaccc gtgcggcggc cccgaggggc tgcgggagcc ggagaaggcc tcgaggccgg     1860

tgcaggagca aggcggggcc aaggcttgag cgccccccat ggctgggagc ccgaagctcg     1920

gagccagggc tcgcgagggc agcaccgcag cctctgcccc agccccggcc acccagggat     1980

cgatcggtac agtcgaggaa gaccacccgg cattctctgc ccactttgcc ttccaggaaa     2040

tgggcttttc aggaagtgaa ttgatgagga ctgtccccat gcccacggat gctcagcagc     2100

ccgccgcact ggggcagatg tctcccctgc cactcctcaa actcgcagca gtaatttgtg     2160

gcactatgac agctattttt atgactatcc tgttctgtgg gggggggggt ctgttttccc     2220

cccatatttg tattcctttt cataactttt cttgatatct ttcctccctc ttttttaatg     2280

taaaggtttt ctcaaaaatt ctcctaaagg tgagggtctc tttcttttct cttttccttt     2340

tttttttctt tttttggcaa cctggctctg gcccaggcta gagtgcagtg gtgcgattat     2400

agcccggtgc agcctctaac tcctgggctc aagcaatcca agtgatcctc ccacctcaac     2460

cttcggagta gctgggatca cagctgcagg ccacgcccag cttcctcccc ccgactcccc     2520

ccccagagac acggtcccac catgttaccc agcctggtct caaactcccc agctaaagca     2580

gtcctccagc ctcggcctcc caaagtactg ggattacagg cgtgagcccc cacgctggcc     2640

tgctttacgt attttctttt gtgcccctgc tcacagtgtt ttagagatgg ctttcccagt     2700

gtgtgttcat tgtaaacact tttgggaaag ggctaaacat gtgaggcctg gagatagttg     2760

ctaagttgct aggaacatgt ggtgggactt tcatattctg aaaaatgttc tatattctca     2820

tttttctaaa agaaagaaaa aaggaaaccc gatttatttc tcctgaatct ttttaagttt     2880

gtgtcgttcc ttaagcagaa ctaagctcag tatgtgacct tacccgctag gtggttaatt     2940

tatccatgct ggcagaggca ctcaggtact tggtaagcaa atttctaaaa ctccaagttg     3000

ctgcagcttg gcattcttct tattctagag gtctctctgg aaaagatgga gaaaatgaac     3060

aggacatggg gctcctggaa agaaagggcc cgggaagttc aaggaagaat aaagttgaaa     3120

ttttaaaaaa aaa                                                        3133


<210>  15
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  15
agaaataatg tatggaggga ctatacaagg gcatatatac tagtaaaagt gttttctcaa       60

tagatcacca aagaatttgc cacacctgat atatagaaaa gtttattgtg cagcacctct      120

accttcgctc tcctgctcct gctctggcca cataaaacgt gctggctcct cctttgcctt      180

ctgctatcat tggaagcttc ctgatgcctc ccaagaagca aatgccatca tggttcctgt      240

acagcctgca gaaccccccg aggtactgaa gagtgagccg tatggggaga aggctgatgt      300

ctgggcagta ggctgcatcc tttatcagat ggcgactttg agtcccccct tctacagcac      360

taacatgctg tccttggcta caaaaatagt ggaggcggta tatgaaccag tcccagaagg      420

tatctactct gaaaaagtaa cagacaccat cagcaggtgc ctcactcctg atgcggaagc      480

tcgtccagat attgtagaag tcagttcgat gatatcagat gtcatgatga aatatttaga      540

caacttatct acatcccagt tgtccttgga aaagaagcta gaacgggaac gaagacgcac      600

acaaaggtat tttatggaag ccaaccggaa caccgtcaca tgtcaccatg agctggctgt      660

tctatctcac gagacctttg agaaggcaag tttgagtagc agcagcagtg gagcagccag      720

cctgaaaagt gaactttcag aaagcgcaga cctgccccct gaaggcttcc aggcctccta      780

tggtaaagac gaagacaggg cctgtgacga aatcctgtca gatgataact tcaacctgga      840

aaatgctgag aaagatacat attcagaggt agatgatgaa ttggacattt cggataactc      900

cagcagctcc agttcaagcc ctctgaaaga atctacattc aacattttaa agagaagttt      960

tagtgcttca ggaggagaaa gacaatccca aacaagggac ttcactggag gaacaggatc     1020

aagaccaaga ccagctttgc tgcctcttga cctgcttctg aaagtgccac cccacatgct     1080

cagggcccac attaaggaaa tagaggctga gttagtgaca gggtggcagt cccatagcct     1140

tcctgctgtg attcttcgaa atctcaaaga tcatgcatca gcaggaattg ctgtgtccca     1200

gaggaaagtg cgtcagatca gtgatcctat tcagcagata ttaattcagc tgcacaaaat     1260

aatctatatc acacagcttc ctccagcttt gcaccacaat ttgaaaagaa gggttataga     1320

gagattcaag aaatccctct tcagccagca gagtaaccct tgtaatttga aatctgaaat     1380

taaaaagtta tctcagggat ctccagaacc gattgagccc aactttttca cagcagatta     1440

ccatttatta catcgttcat ccggtggaaa cagcctgtcc ccaaatgacc ctacaggttt     1500

accaaccagc attgaattgg aggaaggaat aacatatgaa cagatgcaga ctgtgattga     1560

agaagtcctt gaggaaagtg gctattacaa ttttacatct aacaggtatc attcctatcc     1620

atgggggacc aagaatcacc caaccaaaag atgaaaatgc tgcattttga gtggacttga     1680

ttttctcagt gaagttcaag ttctggactt cagccgctat tgcaagatgc ccaaggattg     1740

ggtgctgcta gagggtgtgg aaaagaccaa gatgccatgg ggcctgcagg acttctttct     1800

gggggtcctg tgctggagta tatgacagct gcggtacttg agggcttcat tgccagaaca     1860

cattatatac aggatgtcag agctaccagt gtgctgctgg gagaaaatgc tgcaaaattc     1920

atcttttgga gggtgggggg aaaacccaaa aacaacaaca aaaaaactct cttacagaat     1980

tttccttaac attaaaaaaa acttgtcata tttttcaaag gcaaaaaaaa aaaaaaa        2037


<210>  16
<211>  3558
<212>  DNA
<213>  Homo sapiens

<400>  16
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag       60

caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt      120

caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg      180

cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct      240

cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc      300

gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat      360

ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca      420

gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca      480

gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag      540

atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat      600

gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag      660

gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg      720

ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc      780

gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc      840

tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact      900

gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc      960

catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag     1020

tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt     1080

tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg     1140

ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac     1200

tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg     1260

cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg     1320

ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc     1380

aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac     1440

attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg     1500

cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc     1560

agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct     1620

cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa     1680

tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg     1740

agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg     1800

gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg     1860

gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc     1920

agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc     1980

tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg     2040

gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc     2100

ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc     2160

ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc     2220

cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt     2280

gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg     2340

gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag     2400

gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact     2460

ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg     2520

ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt     2580

gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc     2640

aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt     2700

gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt     2760

gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag     2820

cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa     2880

ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc     2940

attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct     3000

gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt     3060

gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca     3120

cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc     3180

cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg     3240

cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc     3300

cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg     3360

gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg     3420

gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt     3480

ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattccaaa     3540

aaaaaaaaaa aaaaaaaa                                                   3558


<210>  17
<211>  4706
<212>  DNA
<213>  Homo sapiens

<400>  17
cgcggccccg gaggcagcag cagcggcggc ggcagccgga gcagtaggca cccgagcagc       60

gccagcggcc gagcgggcgg cttcctggcc tgggcgctcc ggtggcggcg gaggtgcgcg      120

cggagccatg gttatcatgt cggagttcag cgcggacccc gcgggccagg gtcagggcca      180

gcagaagccc ctccgggtgg gtttttacga catcgagcgg accctgggca aaggcaactt      240

cgcggtggtg aagctggcgc ggcatcgagt caccaaaacg caggttgcaa taaaaataat      300

tgataaaaca cgattagatt caagcaattt ggagaaaatc tatcgtgagg ttcagctgat      360

gaagcttctg aaccatccac acatcataaa gctttaccag gttatggaaa caaaggacat      420

gctttacatc gtcactgaat ttgctaaaaa tggagaaatg tttgattatt tgacttccaa      480

cgggcacctg agtgagaacg aggcgcggaa gaagttctgg caaatcctgt cggccgtgga      540

gtactgtcac gaccatcaca tcgtccaccg ggacctcaag accgagaacc tcctgctgga      600

tggcaacatg gacatcaagc tggcagattt tggatttggg aatttctaca agtcaggaga      660

gcctctgtcc acgtggtgtg ggagcccccc gtatgccgcc ccggaagtct ttgaggggaa      720

ggagtatgaa ggcccccagc tggacatctg gagcctgggc gtggtgctgt acgtcctggt      780

ctgcggttct ctccccttcg atgggcctaa cctgccgacg ctgagacagc gggtgctgga      840

gggccgcttc cgcatcccct tcttcatgtc tcaagactgt gagagcctga tccgccgcat      900

gctggtggtg gaccccgcca ggcgcatcac catcgcccag atccggcagc accggtggat      960

gcgggctgag ccctgcttgc cgggacccgc ctgccccgcc ttctccgcac acagctacac     1020

ctccaacctg ggcgactacg atgagcaggc gctgggtatc atgcagaccc tgggcgtgga     1080

ccggcagagg acggtggagt cactgcaaaa cagcagctat aaccactttg ctgccattta     1140

ttacctcctc cttgagcggc tcaaggagta tcggaatgcc cagtgcgccc gccccgggcc     1200

tgccaggcag ccgcggcctc ggagctcgga cctcagtggt ttggaggtgc ctcaggaagg     1260

tctttccacc gaccctttcc gacctgcctt gctgtgcccg cagccgcaga ccttggtgca     1320

gtccgtcctc caggccgaga tggactgtga gctccagagc tcgctgcagt ggcccttgtt     1380

cttcccggtg gatgccagct gcagcggagt gttccggccc cggcccgtgt ccccaagcag     1440

cctgctggac acagccatca gtgaggaggc caggcagggg ccgggcctag aggaggagca     1500

ggacacgcag gagtccctgc ccagcagcac gggccggagg cacaccctgg ccgaggtctc     1560

cacccgcctc tccccactca ccgcgccatg tatagtcgtc tccccctcca ccacggcaag     1620

tcctgcagag ggaaccagct ctgacagttg tctgaccttc tctgcgagca aaagccccgc     1680

ggggctcagt ggcaccccgg ccactcaggg gctgctgggc gcctgctccc cggtcaggct     1740

ggcctcgccc ttcctggggt cgcagtccgc caccccagtg ctgcaggctc aggggggctt     1800

gggaggagct gttctgctcc ctgtcagctt ccaggaggga cggcgggcgt cggacacctc     1860

actgactcaa gggctgaagg cctttcggca gcagctgagg aagaccacgc ggaccaaagg     1920

gtttctggga ctgaacaaaa tcaaggggct ggctcgccag gtgtgccagg cccccgccag     1980

ccgggccagc aggggcggcc tgagcccctt ccacgcccct gcacagagcc caggcctgca     2040

cggcggcgca gccggcagcc gggagggctg gagcctgctg gaggaggtgc tagagcagca     2100

gaggctgctc cagttacagc accacccggc cgctgcaccc ggctgctccc aggcccccca     2160

gccggcccct gccccgtttg tgatcgcccc ctgtgatggc cctggggctg ccccgctccc     2220

cagcaccctc ctcacgtcgg ggctcccgct gctgccgccc ccactcctgc agaccggcgc     2280

gtccccggtg gcctcagcgg cgcagctcct ggacacacac ctgcacattg gcaccggccc     2340

caccgccctc cccgctgtgc ccccaccacg cctggccagg ctggccccag gttgtgagcc     2400

cctggggctg ctgcaggggg actgtgagat ggaggacctg atgccctgct ccctaggcac     2460

gtttgtcctg gtgcagtgag ggcagccctg catcctggca cggacactga ctcttacagc     2520

aataacttca gaggaggtga agacatctgg cctcaaagcc aagaactttc tagaagcgaa     2580

ataagcaata cgttaggtgt tttggctttt tagtttattt ttgttttatt tttttcttgc     2640

actgagtgac ctcaactttg agtagggact ggaaacttta ggaagaaaga taattgaggg     2700

gcgtgtctgg gggcgggggc aggaggggag cggggtggag ggaacacgtg cagtgccgtg     2760

gtgtggggat ctcggcccct ctctctgggt tcgtcgtggt tgagatgatt acctcggacg     2820

tctacggaaa cgagcgggcg cattgttgtc cgcttgtgtg tgtgtgtgtg tgtgtgtgtg     2880

tgcgcgtgca ttgattacta tccatttctt tagtcaacgc tctccacttc ctgatttctg     2940

ctttaaggaa aactgtgaac tttctgcttc atgtatcagt tttaaagcag cccaggcaaa     3000

gatcatctac agattctagg aattctctcc cctgaaatca aaacctggaa gacttttttt     3060

tcttatttta gttgagaagt ttcataaact gctcaaggat tagttttcca ggactctgcg     3120

gaggaacggc aggaagaacc tcagagaggg cagaggtgac ttcaaagtgc tggggactcc     3180

gtcctgaggg tcacttggcc ctgagcccct gcgtgccctt gcggaagccc agaagcttct     3240

tcctgctgca cctcccgttt ccgctgctgc tgacgtttat gcatttcatg atggggtcca     3300

acaagaacac ctgacttggg tgaagttgtg caatattgga ggctgactgt agggctgggc     3360

agctgggaga caggctcatg gctcatggct catggctcag ggcggtgcct gccctgggcc     3420

gggacccccc tccccacccc ccacctaggc tttttgggtt ttgttcaagg aaggtaaagt     3480

gagaggttta ggtcagtgtt tttaagtttt tgtttttttt ttaaagcaaa tcctgtatat     3540

gtatctacat gggagacagg tagacactac ttatttgtta cattttgtac tatacgtttg     3600

tgttccaggt ttcagcttcc ctcgctcctg ttgttaagaa gcgtccctgt cagcacaggt     3660

gtgcattgag gaaggggccc cagggccttc gctccctcag cactggggtg gaggcggcag     3720

gaaggggcgg cccttacctg gcaggtctgg gcgcaccttt agcaggtgga ctccgtgggg     3780

ctccaccagc cagaagcctc tggaaggcaa cgaaggcaat gctgctccct gagtccagtc     3840

cccgccccca aacccagccc aggtgccttc agctacttcg gcttcttaaa ccctgcagtg     3900

ttaaacagag gcattgagaa aggggaaagg cgggtatttt taaaagccaa agattgaccc     3960

agttacttga gggtagggag gcgggcccag tgcaggaggc tgcatccctg gcctgctggt     4020

gcccaccggg ggctgtgcct gtgccgggcc gcagggaagc tggctgcccc cattcctgct     4080

gctgctgctg ctgctgctct gtggctgttt caaagactgg gcgaaaggct gtccggaggg     4140

cagaccaggt gccttgccgc agagaaaaca ccaaagtctc ctgttcgctc ataaagaagt     4200

ttttgggatg ggagagaatc cagaccatct tggggcagcc aggcccttgc cttcattttt     4260

acagaggtag cacaactgat tccaacacaa aaccccttcc cctttttaaa atgatttctg     4320

ttctaatgcc atagatcaaa ggcctcagaa accattgtgt gtttcctctt tgaagcaatg     4380

acaagcactt tactttcacg gtggtttttg ttttttctta ttgctgtgga acctcttttg     4440

gaggacgtta aaggcgtgtt ttacttgttt ttttaagagt gtgtgatgtg tgttttgtag     4500

atttcttgac agtgctgtaa tacagacggc aatgcaatag cctatttaaa gacactacgt     4560

gatctgattg agatgtacat agtttttttt tttaccataa ctgaattatt ttatctctta     4620

tgttaacatg agaaatgtat gccaaatgat tagttgatgt atgtttttta atttaatatt     4680

taaataaaat atttggaagg aaaaaa                                          4706


<210>  18
<211>  5038
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp 
1               5                   10                  15      


Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu 
            20                  25                  30          


Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu 
        35                  40                  45              


Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys 
    50                  55                  60                  


Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met 
65                  70                  75                  80  


Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly 
                85                  90                  95      


His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His 
            100                 105                 110         


Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp 
        115                 120                 125             


Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala 
    130                 135                 140                 


Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu 
                165                 170                 175     


Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala 
            180                 185                 190         


Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys 
        195                 200                 205             


Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly 
    210                 215                 220                 


His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln 
225                 230                 235                 240 


Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg 
                245                 250                 255     


Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His 
            260                 265                 270         


Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln 
        275                 280                 285             


Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser 
    290                 295                 300                 


Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro 
                325                 330                 335     


Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser 
            340                 345                 350         


Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu 
        355                 360                 365             


Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp 
    370                 375                 380                 


Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala 
385                 390                 395                 400 


Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser 
                405                 410                 415     


Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly 
            420                 425                 430         


Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile 
        435                 440                 445             


Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln 
    450                 455                 460                 


Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr 
                485                 490                 495     


Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu 
            500                 505                 510         


Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu 
        515                 520                 525             


Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp 
    530                 535                 540                 


Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu 
545                 550                 555                 560 


Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile 
                565                 570                 575     


Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
            580                 585                 590         


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
        595                 600                 605             


Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu 
    610                 615                 620                 


Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val 
625                 630                 635                 640 


Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr 
                645                 650                 655     


Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro 
            660                 665                 670         


Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr 
        675                 680                 685             


Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn 
    690                 695                 700                 


Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu 
705                 710                 715                 720 


Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu 
                725                 730                 735     


Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro 
            740                 745                 750         


Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu 
        755                 760                 765             


Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
    770                 775                 780                 


Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
785                 790                 795                 800 


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro 
                805                 810                 815     


Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly 
            820                 825                 830         


Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr 
        835                 840                 845             


Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro 
    850                 855                 860                 


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
865                 870                 875                 880 


Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg 
                885                 890                 895     


Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu 
            900                 905                 910         


Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu 
        915                 920                 925             


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys 
    930                 935                 940                 


Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met 
945                 950                 955                 960 


Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu 
                965                 970                 975     


Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His 
            980                 985                 990         


Asn Val Trp Ala Arg Asp Arg Val  Gly Gln Gly Trp Ser  Tyr Ser Ala 
        995                 1000                 1005             


Val Gln  Asp Ile Pro Ala Arg  Arg Asn Pro Arg Leu  Val Pro Tyr 
    1010                 1015                 1020             


Arg Leu  Leu Asp Glu Ala Thr  Lys Arg Ser Asn Arg  Asp Ser Leu 
    1025                 1030                 1035             


Cys Gln  Ala Val Arg Thr Leu  Leu Gly Tyr Gly Tyr  Asn Ile Glu 
    1040                 1045                 1050             


Pro Pro  Asp Gln Glu Pro Ser  Gln Val Glu Asn Gln  Ser Arg Cys 
    1055                 1060                 1065             


Asp Arg  Val Arg Ile Phe Arg  Ala Glu Lys Ser Tyr  Thr Val Gln 
    1070                 1075                 1080             


Ser Gly  Arg Trp Tyr Phe Glu  Phe Glu Ala Val Thr  Thr Gly Glu 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Glu Leu Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Glu Leu Ala  Tyr Val Phe Asn Gly  His Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Leu Gly Ser  Glu Pro Phe Gly Arg  Pro Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asp Leu Thr  Glu Asn Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Asn Gly  Glu Val Leu Met Ser  Asp Ser Gly 
    1160                 1165                 1170             


Ser Glu  Thr Ala Phe Arg Glu  Ile Glu Ile Gly Asp  Gly Phe Leu 
    1175                 1180                 1185             


Pro Val  Cys Ser Leu Gly Pro  Gly Gln Val Gly His  Leu Asn Leu 
    1190                 1195                 1200             


Gly Gln  Asp Val Ser Ser Leu  Arg Phe Phe Ala Ile  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Ile Asn Met Gln  Arg Pro Val 
    1220                 1225                 1230             


Thr Thr  Trp Phe Ser Lys Gly  Leu Pro Gln Phe Glu  Pro Val Pro 
    1235                 1240                 1245             


Leu Glu  His Pro His Tyr Glu  Val Ser Arg Val Asp  Gly Thr Val 
    1250                 1255                 1260             


Asp Thr  Pro Pro Cys Leu Arg  Leu Thr His Arg Thr  Trp Gly Ser 
    1265                 1270                 1275             


Gln Asn  Ser Leu Val Glu Met  Leu Phe Leu Arg Leu  Ser Leu Pro 
    1280                 1285                 1290             


Val Gln  Phe His Gln His Phe  Arg Cys Thr Ala Gly  Ala Thr Pro 
    1295                 1300                 1305             


Leu Ala  Pro Pro Gly Leu Gln  Pro Pro Ala Glu Asp  Glu Ala Arg 
    1310                 1315                 1320             


Ala Ala  Glu Pro Asp Pro Asp  Tyr Glu Asn Leu Arg  Arg Ser Ala 
    1325                 1330                 1335             


Gly Gly  Trp Ser Glu Ala Glu  Asn Gly Lys Glu Gly  Thr Ala Lys 
    1340                 1345                 1350             


Glu Gly  Ala Pro Gly Gly Thr  Pro Gln Ala Gly Gly  Glu Ala Gln 
    1355                 1360                 1365             


Pro Ala  Arg Ala Glu Asn Glu  Lys Asp Ala Thr Thr  Glu Lys Asn 
    1370                 1375                 1380             


Lys Lys  Arg Gly Phe Leu Phe  Lys Ala Lys Lys Val  Ala Met Met 
    1385                 1390                 1395             


Thr Gln  Pro Pro Ala Thr Pro  Thr Leu Pro Arg Leu  Pro His Asp 
    1400                 1405                 1410             


Val Val  Pro Ala Asp Asn Arg  Asp Asp Pro Glu Ile  Ile Leu Asn 
    1415                 1420                 1425             


Thr Thr  Thr Tyr Tyr Tyr Ser  Val Arg Val Phe Ala  Gly Gln Glu 
    1430                 1435                 1440             


Pro Ser  Cys Val Trp Ala Gly  Trp Val Thr Pro Asp  Tyr His Gln 
    1445                 1450                 1455             


His Asp  Met Ser Phe Asp Leu  Ser Lys Val Arg Val  Val Thr Val 
    1460                 1465                 1470             


Thr Met  Gly Asp Glu Gln Gly  Asn Val His Ser Ser  Leu Lys Cys 
    1475                 1480                 1485             


Ser Asn  Cys Tyr Met Val Trp  Gly Gly Asp Phe Val  Ser Pro Gly 
    1490                 1495                 1500             


Gln Gln  Gly Arg Ile Ser His  Thr Asp Leu Val Ile  Gly Cys Leu 
    1505                 1510                 1515             


Val Asp  Leu Ala Thr Gly Leu  Met Thr Phe Thr Ala  Asn Gly Lys 
    1520                 1525                 1530             


Glu Ser  Asn Thr Phe Phe Gln  Val Glu Pro Asn Thr  Lys Leu Phe 
    1535                 1540                 1545             


Pro Ala  Val Phe Val Leu Pro  Thr His Gln Asn Val  Ile Gln Phe 
    1550                 1555                 1560             


Glu Leu  Gly Lys Gln Lys Asn  Ile Met Pro Leu Ser  Ala Ala Met 
    1565                 1570                 1575             


Phe Gln  Ser Glu Arg Lys Asn  Pro Ala Pro Gln Cys  Pro Pro Arg 
    1580                 1585                 1590             


Leu Glu  Met Gln Met Leu Met  Pro Val Ser Trp Ser  Arg Met Pro 
    1595                 1600                 1605             


Asn His  Phe Leu Gln Val Glu  Thr Arg Arg Ala Gly  Glu Arg Leu 
    1610                 1615                 1620             


Gly Trp  Ala Val Gln Cys Gln  Glu Pro Leu Thr Met  Met Ala Leu 
    1625                 1630                 1635             


His Ile  Pro Glu Glu Asn Arg  Cys Met Asp Ile Leu  Glu Leu Ser 
    1640                 1645                 1650             


Glu Arg  Leu Asp Leu Gln Arg  Phe His Ser His Thr  Leu Arg Leu 
    1655                 1660                 1665             


Tyr Arg  Ala Val Cys Ala Leu  Gly Asn Asn Arg Val  Ala His Ala 
    1670                 1675                 1680             


Leu Cys  Ser His Val Asp Gln  Ala Gln Leu Leu His  Ala Leu Glu 
    1685                 1690                 1695             


Asp Ala  His Leu Pro Gly Pro  Leu Arg Ala Gly Tyr  Tyr Asp Leu 
    1700                 1705                 1710             


Leu Ile  Ser Ile His Leu Glu  Ser Ala Cys Arg Ser  Arg Arg Ser 
    1715                 1720                 1725             


Met Leu  Ser Glu Tyr Ile Val  Pro Leu Thr Pro Glu  Thr Arg Ala 
    1730                 1735                 1740             


Ile Thr  Leu Phe Pro Pro Gly  Arg Ser Thr Glu Asn  Gly His Pro 
    1745                 1750                 1755             


Arg His  Gly Leu Pro Gly Val  Gly Val Thr Thr Ser  Leu Arg Pro 
    1760                 1765                 1770             


Pro His  His Phe Ser Pro Pro  Cys Phe Val Ala Ala  Leu Pro Ala 
    1775                 1780                 1785             


Ala Gly  Ala Ala Glu Ala Pro  Ala Arg Leu Ser Pro  Ala Ile Pro 
    1790                 1795                 1800             


Leu Glu  Ala Leu Arg Asp Lys  Ala Leu Arg Met Leu  Gly Glu Ala 
    1805                 1810                 1815             


Val Arg  Asp Gly Gly Gln His  Ala Arg Asp Pro Val  Gly Gly Ser 
    1820                 1825                 1830             


Val Glu  Phe Gln Phe Val Pro  Val Leu Lys Leu Val  Ser Thr Leu 
    1835                 1840                 1845             


Leu Val  Met Gly Ile Phe Gly  Asp Glu Asp Val Lys  Gln Ile Leu 
    1850                 1855                 1860             


Lys Met  Ile Glu Pro Glu Val  Phe Thr Glu Glu Glu  Glu Glu Glu 
    1865                 1870                 1875             


Asp Glu  Glu Glu Glu Gly Glu  Glu Glu Asp Glu Glu  Glu Lys Glu 
    1880                 1885                 1890             


Glu Asp  Glu Glu Glu Thr Ala  Gln Glu Lys Glu Asp  Glu Glu Lys 
    1895                 1900                 1905             


Glu Glu  Glu Glu Ala Ala Glu  Gly Glu Lys Glu Glu  Gly Leu Glu 
    1910                 1915                 1920             


Glu Gly  Leu Leu Gln Met Lys  Leu Pro Glu Ser Val  Lys Leu Gln 
    1925                 1930                 1935             


Met Cys  His Leu Leu Glu Tyr  Phe Cys Asp Gln Glu  Leu Gln His 
    1940                 1945                 1950             


Arg Val  Glu Ser Leu Ala Ala  Phe Ala Glu Arg Tyr  Val Asp Lys 
    1955                 1960                 1965             


Leu Gln  Ala Asn Gln Arg Ser  Arg Tyr Gly Leu Leu  Ile Lys Ala 
    1970                 1975                 1980             


Phe Ser  Met Thr Ala Ala Glu  Thr Ala Arg Arg Thr  Arg Glu Phe 
    1985                 1990                 1995             


Arg Ser  Pro Pro Gln Glu Gln  Ile Asn Met Leu Leu  Gln Phe Lys 
    2000                 2005                 2010             


Asp Gly  Thr Asp Glu Glu Asp  Cys Pro Leu Pro Glu  Glu Ile Arg 
    2015                 2020                 2025             


Gln Asp  Leu Leu Asp Phe His  Gln Asp Leu Leu Ala  His Cys Gly 
    2030                 2035                 2040             


Ile Gln  Leu Asp Gly Glu Glu  Glu Glu Pro Glu Glu  Glu Thr Thr 
    2045                 2050                 2055             


Leu Gly  Ser Arg Leu Met Ser  Leu Leu Glu Lys Val  Arg Leu Val 
    2060                 2065                 2070             


Lys Lys  Lys Glu Glu Lys Pro  Glu Glu Glu Arg Ser  Ala Glu Glu 
    2075                 2080                 2085             


Ser Lys  Pro Arg Ser Leu Gln  Glu Leu Val Ser His  Met Val Val 
    2090                 2095                 2100             


Arg Trp  Ala Gln Glu Asp Phe  Val Gln Ser Pro Glu  Leu Val Arg 
    2105                 2110                 2115             


Ala Met  Phe Ser Leu Leu His  Arg Gln Tyr Asp Gly  Leu Gly Glu 
    2120                 2125                 2130             


Leu Leu  Arg Ala Leu Pro Arg  Ala Tyr Thr Ile Ser  Pro Ser Ser 
    2135                 2140                 2145             


Val Glu  Asp Thr Met Ser Leu  Leu Glu Cys Leu Gly  Gln Ile Arg 
    2150                 2155                 2160             


Ser Leu  Leu Ile Val Gln Met  Gly Pro Gln Glu Glu  Asn Leu Met 
    2165                 2170                 2175             


Ile Gln  Ser Ile Gly Asn Ile  Met Asn Asn Lys Val  Phe Tyr Gln 
    2180                 2185                 2190             


His Pro  Asn Leu Met Arg Ala  Leu Gly Met His Glu  Thr Val Met 
    2195                 2200                 2205             


Glu Val  Met Val Asn Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile 
    2210                 2215                 2220             


Arg Phe  Pro Lys Met Val Thr  Ser Cys Cys Arg Phe  Leu Cys Tyr 
    2225                 2230                 2235             


Phe Cys  Arg Ile Ser Arg Gln  Asn Gln Arg Ser Met  Phe Asp His 
    2240                 2245                 2250             


Leu Ser  Tyr Leu Leu Glu Asn  Ser Gly Ile Gly Leu  Gly Met Gln 
    2255                 2260                 2265             


Gly Ser  Thr Pro Leu Asp Val  Ala Ala Ala Ser Val  Ile Asp Asn 
    2270                 2275                 2280             


Asn Glu  Leu Ala Leu Ala Leu  Gln Glu Gln Asp Leu  Glu Lys Val 
    2285                 2290                 2295             


Val Ser  Tyr Leu Ala Gly Cys  Gly Leu Gln Ser Cys  Pro Met Leu 
    2300                 2305                 2310             


Val Ala  Lys Gly Tyr Pro Asp  Ile Gly Trp Asn Pro  Cys Gly Gly 
    2315                 2320                 2325             


Glu Arg  Tyr Leu Asp Phe Leu  Arg Phe Ala Val Phe  Val Asn Gly 
    2330                 2335                 2340             


Glu Ser  Val Glu Glu Asn Ala  Asn Val Val Val Arg  Leu Leu Ile 
    2345                 2350                 2355             


Arg Lys  Pro Glu Cys Phe Gly  Pro Ala Leu Arg Gly  Glu Gly Gly 
    2360                 2365                 2370             


Ser Gly  Leu Leu Ala Ala Ile  Glu Glu Ala Ile Arg  Ile Ser Glu 
    2375                 2380                 2385             


Asp Pro  Ala Arg Asp Gly Pro  Gly Ile Arg Arg Asp  Arg Arg Arg 
    2390                 2395                 2400             


Glu His  Phe Gly Glu Glu Pro  Pro Glu Glu Asn Arg  Val His Leu 
    2405                 2410                 2415             


Gly His  Ala Ile Met Ser Phe  Tyr Ala Ala Leu Ile  Asp Leu Leu 
    2420                 2425                 2430             


Gly Arg  Cys Ala Pro Glu Met  His Leu Ile Gln Ala  Gly Lys Gly 
    2435                 2440                 2445             


Glu Ala  Leu Arg Ile Arg Ala  Ile Leu Arg Ser Leu  Val Pro Leu 
    2450                 2455                 2460             


Glu Asp  Leu Val Gly Ile Ile  Ser Leu Pro Leu Gln  Ile Pro Thr 
    2465                 2470                 2475             


Leu Gly  Lys Asp Gly Ala Leu  Val Gln Pro Lys Met  Ser Ala Ser 
    2480                 2485                 2490             


Phe Val  Pro Asp His Lys Ala  Ser Met Val Leu Phe  Leu Asp Arg 
    2495                 2500                 2505             


Val Tyr  Gly Ile Glu Asn Gln  Asp Phe Leu Leu His  Val Leu Asp 
    2510                 2515                 2520             


Val Gly  Phe Leu Pro Asp Met  Arg Ala Ala Ala Ser  Leu Asp Thr 
    2525                 2530                 2535             


Ala Thr  Phe Ser Thr Thr Glu  Met Ala Leu Ala Leu  Asn Arg Tyr 
    2540                 2545                 2550             


Leu Cys  Leu Ala Val Leu Pro  Leu Ile Thr Lys Cys  Ala Pro Leu 
    2555                 2560                 2565             


Phe Ala  Gly Thr Glu His Arg  Ala Ile Met Val Asp  Ser Met Leu 
    2570                 2575                 2580             


His Thr  Val Tyr Arg Leu Ser  Arg Gly Arg Ser Leu  Thr Lys Ala 
    2585                 2590                 2595             


Gln Arg  Asp Val Ile Glu Asp  Cys Leu Met Ser Leu  Cys Arg Tyr 
    2600                 2605                 2610             


Ile Arg  Pro Ser Met Leu Gln  His Leu Leu Arg Arg  Leu Val Phe 
    2615                 2620                 2625             


Asp Val  Pro Ile Leu Asn Glu  Phe Ala Lys Met Pro  Leu Lys Leu 
    2630                 2635                 2640             


Leu Thr  Asn His Tyr Glu Arg  Cys Trp Lys Tyr Tyr  Cys Leu Pro 
    2645                 2650                 2655             


Thr Gly  Trp Ala Asn Phe Gly  Val Thr Ser Glu Glu  Glu Leu His 
    2660                 2665                 2670             


Leu Thr  Arg Lys Leu Phe Trp  Gly Ile Phe Asp Ser  Leu Ala His 
    2675                 2680                 2685             


Lys Lys  Tyr Asp Pro Glu Leu  Tyr Arg Met Ala Met  Pro Cys Leu 
    2690                 2695                 2700             


Cys Ala  Ile Ala Gly Ala Leu  Pro Pro Asp Tyr Val  Asp Ala Ser 
    2705                 2710                 2715             


Tyr Ser  Ser Lys Ala Glu Lys  Lys Ala Thr Val Asp  Ala Glu Gly 
    2720                 2725                 2730             


Asn Phe  Asp Pro Arg Pro Val  Glu Thr Leu Asn Val  Ile Ile Pro 
    2735                 2740                 2745             


Glu Lys  Leu Asp Ser Phe Ile  Asn Lys Phe Ala Glu  Tyr Thr His 
    2750                 2755                 2760             


Glu Lys  Trp Ala Phe Asp Lys  Ile Gln Asn Asn Trp  Ser Tyr Gly 
    2765                 2770                 2775             


Glu Asn  Ile Asp Glu Glu Leu  Lys Thr His Pro Met  Leu Arg Pro 
    2780                 2785                 2790             


Tyr Lys  Thr Phe Ser Glu Lys  Asp Lys Glu Ile Tyr  Arg Trp Pro 
    2795                 2800                 2805             


Ile Lys  Glu Ser Leu Lys Ala  Met Ile Ala Trp Glu  Trp Thr Ile 
    2810                 2815                 2820             


Glu Lys  Ala Arg Glu Gly Glu  Glu Glu Lys Thr Glu  Lys Lys Lys 
    2825                 2830                 2835             


Thr Arg  Lys Ile Ser Gln Ser  Ala Gln Thr Tyr Asp  Pro Arg Glu 
    2840                 2845                 2850             


Gly Tyr  Asn Pro Gln Pro Pro  Asp Leu Ser Ala Val  Thr Leu Ser 
    2855                 2860                 2865             


Arg Glu  Leu Gln Ala Met Ala  Glu Gln Leu Ala Glu  Asn Tyr His 
    2870                 2875                 2880             


Asn Thr  Trp Gly Arg Lys Lys  Lys Gln Glu Leu Glu  Ala Lys Gly 
    2885                 2890                 2895             


Gly Gly  Thr His Pro Leu Leu  Val Pro Tyr Asp Thr  Leu Thr Ala 
    2900                 2905                 2910             


Lys Glu  Lys Ala Arg Asp Arg  Glu Lys Ala Gln Glu  Leu Leu Lys 
    2915                 2920                 2925             


Phe Leu  Gln Met Asn Gly Tyr  Ala Val Thr Arg Gly  Leu Lys Asp 
    2930                 2935                 2940             


Met Glu  Leu Asp Ser Ser Ser  Ile Glu Lys Arg Phe  Ala Phe Gly 
    2945                 2950                 2955             


Phe Leu  Gln Gln Leu Leu Arg  Trp Met Asp Ile Ser  Gln Glu Phe 
    2960                 2965                 2970             


Ile Ala  His Leu Glu Ala Val  Val Ser Ser Gly Arg  Val Glu Lys 
    2975                 2980                 2985             


Ser Pro  His Glu Gln Glu Ile  Lys Phe Phe Ala Lys  Ile Leu Leu 
    2990                 2995                 3000             


Pro Leu  Ile Asn Gln Tyr Phe  Thr Asn His Cys Leu  Tyr Phe Leu 
    3005                 3010                 3015             


Ser Thr  Pro Ala Lys Val Leu  Gly Ser Gly Gly His  Ala Ser Asn 
    3020                 3025                 3030             


Lys Glu  Lys Glu Met Ile Thr  Ser Leu Phe Cys Lys  Leu Ala Ala 
    3035                 3040                 3045             


Leu Val  Arg His Arg Val Ser  Leu Phe Gly Thr Asp  Ala Pro Ala 
    3050                 3055                 3060             


Val Val  Asn Cys Leu His Ile  Leu Ala Arg Ser Leu  Asp Ala Arg 
    3065                 3070                 3075             


Thr Val  Met Lys Ser Gly Pro  Glu Ile Val Lys Ala  Gly Leu Arg 
    3080                 3085                 3090             


Ser Phe  Phe Glu Ser Ala Ser  Glu Asp Ile Glu Lys  Met Val Glu 
    3095                 3100                 3105             


Asn Leu  Arg Leu Gly Lys Val  Ser Gln Ala Arg Thr  Gln Val Lys 
    3110                 3115                 3120             


Gly Val  Gly Gln Asn Leu Thr  Tyr Thr Thr Val Ala  Leu Leu Pro 
    3125                 3130                 3135             


Val Leu  Thr Thr Leu Phe Gln  His Ile Ala Gln His  Gln Phe Gly 
    3140                 3145                 3150             


Asp Asp  Val Ile Leu Asp Asp  Val Gln Val Ser Cys  Tyr Arg Thr 
    3155                 3160                 3165             


Leu Cys  Ser Ile Tyr Ser Leu  Gly Thr Thr Lys Asn  Thr Tyr Val 
    3170                 3175                 3180             


Glu Lys  Leu Arg Pro Ala Leu  Gly Glu Cys Leu Ala  Arg Leu Ala 
    3185                 3190                 3195             


Ala Ala  Met Pro Val Ala Phe  Leu Glu Pro Gln Leu  Asn Glu Tyr 
    3200                 3205                 3210             


Asn Ala  Cys Ser Val Tyr Thr  Thr Lys Ser Pro Arg  Glu Arg Ala 
    3215                 3220                 3225             


Ile Leu  Gly Leu Pro Asn Ser  Val Glu Glu Met Cys  Pro Asp Ile 
    3230                 3235                 3240             


Pro Val  Leu Glu Arg Leu Met  Ala Asp Ile Gly Gly  Leu Ala Glu 
    3245                 3250                 3255             


Ser Gly  Ala Arg Tyr Thr Glu  Met Pro His Val Ile  Glu Ile Thr 
    3260                 3265                 3270             


Leu Pro  Met Leu Cys Ser Tyr  Leu Pro Arg Trp Trp  Glu Arg Gly 
    3275                 3280                 3285             


Pro Glu  Ala Pro Pro Ser Ala  Leu Pro Ala Gly Ala  Pro Pro Pro 
    3290                 3295                 3300             


Cys Thr  Ala Val Thr Ser Asp  His Leu Asn Ser Leu  Leu Gly Asn 
    3305                 3310                 3315             


Ile Leu  Arg Ile Ile Val Asn  Asn Leu Gly Ile Asp  Glu Ala Ser 
    3320                 3325                 3330             


Trp Met  Lys Arg Leu Ala Val  Phe Ala Gln Pro Ile  Val Ser Arg 
    3335                 3340                 3345             


Ala Arg  Pro Glu Leu Leu Gln  Ser His Phe Ile Pro  Thr Ile Gly 
    3350                 3355                 3360             


Arg Leu  Arg Lys Arg Ala Gly  Lys Val Val Ser Glu  Glu Glu Gln 
    3365                 3370                 3375             


Leu Arg  Leu Glu Ala Lys Ala  Glu Ala Gln Glu Gly  Glu Leu Leu 
    3380                 3385                 3390             


Val Arg  Asp Glu Phe Ser Val  Leu Cys Arg Asp Leu  Tyr Ala Leu 
    3395                 3400                 3405             


Tyr Pro  Leu Leu Ile Arg Tyr  Val Asp Asn Asn Arg  Ala Gln Trp 
    3410                 3415                 3420             


Leu Thr  Glu Pro Asn Pro Ser  Ala Glu Glu Leu Phe  Arg Met Val 
    3425                 3430                 3435             


Gly Glu  Ile Phe Ile Tyr Trp  Ser Lys Ser His Asn  Phe Lys Arg 
    3440                 3445                 3450             


Glu Glu  Gln Asn Phe Val Val  Gln Asn Glu Ile Asn  Asn Met Ser 
    3455                 3460                 3465             


Phe Leu  Thr Ala Asp Asn Lys  Ser Lys Met Ala Lys  Ala Gly Asp 
    3470                 3475                 3480             


Ile Gln  Ser Gly Gly Ser Asp  Gln Glu Arg Thr Lys  Lys Lys Arg 
    3485                 3490                 3495             


Arg Gly  Asp Arg Tyr Ser Val  Gln Thr Ser Leu Ile  Val Ala Thr 
    3500                 3505                 3510             


Leu Lys  Lys Met Leu Pro Ile  Gly Leu Asn Met Cys  Ala Pro Thr 
    3515                 3520                 3525             


Asp Gln  Asp Leu Ile Thr Leu  Ala Lys Thr Arg Tyr  Ala Leu Lys 
    3530                 3535                 3540             


Asp Thr  Asp Glu Glu Val Arg  Glu Phe Leu His Asn  Asn Leu His 
    3545                 3550                 3555             


Leu Gln  Gly Lys Val Glu Gly  Ser Pro Ser Leu Arg  Trp Gln Met 
    3560                 3565                 3570             


Ala Leu  Tyr Arg Gly Val Pro  Gly Arg Glu Glu Asp  Ala Asp Asp 
    3575                 3580                 3585             


Pro Glu  Lys Ile Val Arg Arg  Val Gln Glu Val Ser  Ala Val Leu 
    3590                 3595                 3600             


Tyr Tyr  Leu Asp Gln Thr Glu  His Pro Tyr Lys Ser  Lys Lys Ala 
    3605                 3610                 3615             


Val Trp  His Lys Leu Leu Ser  Lys Gln Arg Arg Arg  Ala Val Val 
    3620                 3625                 3630             


Ala Cys  Phe Arg Met Thr Pro  Leu Tyr Asn Leu Pro  Thr His Arg 
    3635                 3640                 3645             


Ala Cys  Asn Met Phe Leu Glu  Ser Tyr Lys Ala Ala  Trp Ile Leu 
    3650                 3655                 3660             


Thr Glu  Asp His Ser Phe Glu  Asp Arg Met Ile Asp  Asp Leu Ser 
    3665                 3670                 3675             


Lys Ala  Gly Glu Gln Glu Glu  Glu Glu Glu Glu Val  Glu Glu Lys 
    3680                 3685                 3690             


Lys Pro  Asp Pro Leu His Gln  Leu Val Leu His Phe  Ser Arg Thr 
    3695                 3700                 3705             


Ala Leu  Thr Glu Lys Ser Lys  Leu Asp Glu Asp Tyr  Leu Tyr Met 
    3710                 3715                 3720             


Ala Tyr  Ala Asp Ile Met Ala  Lys Ser Cys His Leu  Glu Glu Gly 
    3725                 3730                 3735             


Gly Glu  Asn Gly Glu Ala Glu  Glu Glu Val Glu Val  Ser Phe Glu 
    3740                 3745                 3750             


Glu Lys  Gln Met Glu Lys Gln  Arg Leu Leu Tyr Gln  Gln Ala Arg 
    3755                 3760                 3765             


Leu His  Thr Arg Gly Ala Ala  Glu Met Val Leu Gln  Met Ile Ser 
    3770                 3775                 3780             


Ala Cys  Lys Gly Glu Thr Gly  Ala Met Val Ser Ser  Thr Leu Lys 
    3785                 3790                 3795             


Leu Gly  Ile Ser Ile Leu Asn  Gly Gly Asn Ala Glu  Val Gln Gln 
    3800                 3805                 3810             


Lys Met  Leu Asp Tyr Leu Lys  Asp Lys Lys Glu Val  Gly Phe Phe 
    3815                 3820                 3825             


Gln Ser  Ile Gln Ala Leu Met  Gln Thr Cys Ser Val  Leu Asp Leu 
    3830                 3835                 3840             


Asn Ala  Phe Glu Arg Gln Asn  Lys Ala Glu Gly Leu  Gly Met Val 
    3845                 3850                 3855             


Asn Glu  Asp Gly Thr Val Ile  Asn Arg Gln Asn Gly  Glu Lys Val 
    3860                 3865                 3870             


Met Ala  Asp Asp Glu Phe Thr  Gln Asp Leu Phe Arg  Phe Leu Gln 
    3875                 3880                 3885             


Leu Leu  Cys Glu Gly His Asn  Asn Asp Phe Gln Asn  Tyr Leu Arg 
    3890                 3895                 3900             


Thr Gln  Thr Gly Asn Thr Thr  Thr Ile Asn Ile Ile  Ile Cys Thr 
    3905                 3910                 3915             


Val Asp  Tyr Leu Leu Arg Leu  Gln Glu Ser Ile Ser  Asp Phe Tyr 
    3920                 3925                 3930             


Trp Tyr  Tyr Ser Gly Lys Asp  Val Ile Glu Glu Gln  Gly Lys Arg 
    3935                 3940                 3945             


Asn Phe  Ser Lys Ala Met Ser  Val Ala Lys Gln Val  Phe Asn Ser 
    3950                 3955                 3960             


Leu Thr  Glu Tyr Ile Gln Gly  Pro Cys Thr Gly Asn  Gln Gln Ser 
    3965                 3970                 3975             


Leu Ala  His Ser Arg Leu Trp  Asp Ala Val Val Gly  Phe Leu His 
    3980                 3985                 3990             


Val Phe  Ala His Met Met Met  Lys Leu Ala Gln Asp  Ser Ser Gln 
    3995                 4000                 4005             


Ile Glu  Leu Leu Lys Glu Leu  Leu Asp Leu Gln Lys  Asp Met Val 
    4010                 4015                 4020             


Val Met  Leu Leu Ser Leu Leu  Glu Gly Asn Val Val  Asn Gly Met 
    4025                 4030                 4035             


Ile Ala  Arg Gln Met Val Asp  Met Leu Val Glu Ser  Ser Ser Asn 
    4040                 4045                 4050             


Val Glu  Met Ile Leu Lys Phe  Phe Asp Met Phe Leu  Lys Leu Lys 
    4055                 4060                 4065             


Asp Ile  Val Gly Ser Glu Ala  Phe Gln Asp Tyr Val  Thr Asp Pro 
    4070                 4075                 4080             


Arg Gly  Leu Ile Ser Lys Lys  Asp Phe Gln Lys Ala  Met Asp Ser 
    4085                 4090                 4095             


Gln Lys  Gln Phe Ser Gly Pro  Glu Ile Gln Phe Leu  Leu Ser Cys 
    4100                 4105                 4110             


Ser Glu  Ala Asp Glu Asn Glu  Met Ile Asn Cys Glu  Glu Phe Ala 
    4115                 4120                 4125             


Asn Arg  Phe Gln Glu Pro Ala  Arg Asp Ile Gly Phe  Asn Val Ala 
    4130                 4135                 4140             


Val Leu  Leu Thr Asn Leu Ser  Glu His Val Pro His  Asp Pro Arg 
    4145                 4150                 4155             


Leu His  Asn Phe Leu Glu Leu  Ala Glu Ser Ile Leu  Glu Tyr Phe 
    4160                 4165                 4170             


Arg Pro  Tyr Leu Gly Arg Ile  Glu Ile Met Gly Ala  Ser Arg Arg 
    4175                 4180                 4185             


Ile Glu  Arg Ile Tyr Phe Glu  Ile Ser Glu Thr Asn  Arg Ala Gln 
    4190                 4195                 4200             


Trp Glu  Met Pro Gln Val Lys  Glu Ser Lys Arg Gln  Phe Ile Phe 
    4205                 4210                 4215             


Asp Val  Val Asn Glu Gly Gly  Glu Ala Glu Lys Met  Glu Leu Phe 
    4220                 4225                 4230             


Val Ser  Phe Cys Glu Asp Thr  Ile Phe Glu Met Gln  Ile Ala Ala 
    4235                 4240                 4245             


Gln Ile  Ser Glu Pro Glu Gly  Glu Pro Glu Thr Asp  Glu Asp Glu 
    4250                 4255                 4260             


Gly Ala  Gly Ala Ala Glu Ala  Gly Ala Glu Gly Ala  Glu Glu Gly 
    4265                 4270                 4275             


Ala Ala  Gly Leu Glu Gly Thr  Ala Ala Thr Ala Ala  Ala Gly Ala 
    4280                 4285                 4290             


Thr Ala  Arg Val Val Ala Ala  Ala Gly Arg Ala Leu  Arg Gly Leu 
    4295                 4300                 4305             


Ser Tyr  Arg Ser Leu Arg Arg  Arg Val Arg Arg Leu  Arg Arg Leu 
    4310                 4315                 4320             


Thr Ala  Arg Glu Ala Ala Thr  Ala Val Ala Ala Leu  Leu Trp Ala 
    4325                 4330                 4335             


Ala Val  Thr Arg Ala Gly Ala  Ala Gly Ala Gly Ala  Ala Ala Gly 
    4340                 4345                 4350             


Ala Leu  Gly Leu Leu Trp Gly  Ser Leu Phe Gly Gly  Gly Leu Val 
    4355                 4360                 4365             


Glu Gly  Ala Lys Lys Val Thr  Val Thr Glu Leu Leu  Ala Gly Met 
    4370                 4375                 4380             


Pro Asp  Pro Thr Ser Asp Glu  Val His Gly Glu Gln  Pro Ala Gly 
    4385                 4390                 4395             


Pro Gly  Gly Asp Ala Asp Gly  Glu Gly Ala Ser Glu  Gly Ala Gly 
    4400                 4405                 4410             


Asp Ala  Ala Glu Gly Ala Gly  Asp Glu Glu Glu Ala  Val His Glu 
    4415                 4420                 4425             


Ala Gly  Pro Gly Gly Ala Asp  Gly Ala Val Ala Val  Thr Asp Gly 
    4430                 4435                 4440             


Gly Pro  Phe Arg Pro Glu Gly  Ala Gly Gly Leu Gly  Asp Met Gly 
    4445                 4450                 4455             


Asp Thr  Thr Pro Ala Glu Pro  Pro Thr Pro Glu Gly  Ser Pro Ile 
    4460                 4465                 4470             


Leu Lys  Arg Lys Leu Gly Val  Asp Gly Val Glu Glu  Glu Leu Pro 
    4475                 4480                 4485             


Pro Glu  Pro Glu Pro Glu Pro  Glu Pro Glu Leu Glu  Pro Glu Lys 
    4490                 4495                 4500             


Ala Asp  Ala Glu Asn Gly Glu  Lys Glu Glu Val Pro  Glu Pro Thr 
    4505                 4510                 4515             


Pro Glu  Pro Pro Lys Lys Gln  Ala Pro Pro Ser Pro  Pro Pro Lys 
    4520                 4525                 4530             


Lys Glu  Glu Ala Gly Gly Glu  Phe Trp Gly Glu Leu  Glu Val Gln 
    4535                 4540                 4545             


Arg Val  Lys Phe Leu Asn Tyr  Leu Ser Arg Asn Phe  Tyr Thr Leu 
    4550                 4555                 4560             


Arg Phe  Leu Ala Leu Phe Leu  Ala Phe Ala Ile Asn  Phe Ile Leu 
    4565                 4570                 4575             


Leu Phe  Tyr Lys Val Ser Asp  Ser Pro Pro Gly Glu  Asp Asp Met 
    4580                 4585                 4590             


Glu Gly  Ser Ala Ala Gly Asp  Val Ser Gly Ala Gly  Ser Gly Gly 
    4595                 4600                 4605             


Ser Ser  Gly Trp Gly Leu Gly  Ala Gly Glu Glu Ala  Glu Gly Asp 
    4610                 4615                 4620             


Glu Asp  Glu Asn Met Val Tyr  Tyr Phe Leu Glu Glu  Ser Thr Gly 
    4625                 4630                 4635             


Tyr Met  Glu Pro Ala Leu Arg  Cys Leu Ser Leu Leu  His Thr Leu 
    4640                 4645                 4650             


Val Ala  Phe Leu Cys Ile Ile  Gly Tyr Asn Cys Leu  Lys Val Pro 
    4655                 4660                 4665             


Leu Val  Ile Phe Lys Arg Glu  Lys Glu Leu Ala Arg  Lys Leu Glu 
    4670                 4675                 4680             


Phe Asp  Gly Leu Tyr Ile Thr  Glu Gln Pro Glu Asp  Asp Asp Val 
    4685                 4690                 4695             


Lys Gly  Gln Trp Asp Arg Leu  Val Leu Asn Thr Pro  Ser Phe Pro 
    4700                 4705                 4710             


Ser Asn  Tyr Trp Asp Lys Phe  Val Lys Arg Lys Val  Leu Asp Lys 
    4715                 4720                 4725             


His Gly  Asp Ile Tyr Gly Arg  Glu Arg Ile Ala Glu  Leu Leu Gly 
    4730                 4735                 4740             


Met Asp  Leu Ala Thr Leu Glu  Ile Thr Ala His Asn  Glu Arg Lys 
    4745                 4750                 4755             


Pro Asn  Pro Pro Pro Gly Leu  Leu Thr Trp Leu Met  Ser Ile Asp 
    4760                 4765                 4770             


Val Lys  Tyr Gln Ile Trp Lys  Phe Gly Val Ile Phe  Thr Asp Asn 
    4775                 4780                 4785             


Ser Phe  Leu Tyr Leu Gly Trp  Tyr Met Val Met Ser  Leu Leu Gly 
    4790                 4795                 4800             


His Tyr  Asn Asn Phe Phe Phe  Ala Ala His Leu Leu  Asp Ile Ala 
    4805                 4810                 4815             


Met Gly  Val Lys Thr Leu Arg  Thr Ile Leu Ser Ser  Val Thr His 
    4820                 4825                 4830             


Asn Gly  Lys Gln Leu Val Met  Thr Val Gly Leu Leu  Ala Val Val 
    4835                 4840                 4845             


Val Tyr  Leu Tyr Thr Val Val  Ala Phe Asn Phe Phe  Arg Lys Phe 
    4850                 4855                 4860             


Tyr Asn  Lys Ser Glu Asp Glu  Asp Glu Pro Asp Met  Lys Cys Asp 
    4865                 4870                 4875             


Asp Met  Met Thr Cys Tyr Leu  Phe His Met Tyr Val  Gly Val Arg 
    4880                 4885                 4890             


Ala Gly  Gly Gly Ile Gly Asp  Glu Ile Glu Asp Pro  Ala Gly Asp 
    4895                 4900                 4905             


Glu Tyr  Glu Leu Tyr Arg Val  Val Phe Asp Ile Thr  Phe Phe Phe 
    4910                 4915                 4920             


Phe Val  Ile Val Ile Leu Leu  Ala Ile Ile Gln Gly  Leu Ile Ile 
    4925                 4930                 4935             


Asp Ala  Phe Gly Glu Leu Arg  Asp Gln Gln Glu Gln  Val Lys Glu 
    4940                 4945                 4950             


Asp Met  Glu Thr Lys Cys Phe  Ile Cys Gly Ile Gly  Ser Asp Tyr 
    4955                 4960                 4965             


Phe Asp  Thr Thr Pro His Gly  Phe Glu Thr His Thr  Leu Glu Glu 
    4970                 4975                 4980             


His Asn  Leu Ala Asn Tyr Met  Phe Phe Leu Met Tyr  Leu Ile Asn 
    4985                 4990                 4995             


Lys Asp  Glu Thr Glu His Thr  Gly Gln Glu Ser Tyr  Val Trp Lys 
    5000                 5005                 5010             


Met Tyr  Gln Glu Arg Cys Trp  Asp Phe Phe Pro Ala  Gly Asp Cys 
    5015                 5020                 5025             


Phe Arg  Lys Gln Tyr Glu Asp  Gln Leu Ser 
    5030                 5035             


<210>  19
<211>  5033
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp 
1               5                   10                  15      


Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu 
            20                  25                  30          


Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu 
        35                  40                  45              


Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys 
    50                  55                  60                  


Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met 
65                  70                  75                  80  


Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly 
                85                  90                  95      


His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His 
            100                 105                 110         


Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp 
        115                 120                 125             


Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala 
    130                 135                 140                 


Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu 
                165                 170                 175     


Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala 
            180                 185                 190         


Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys 
        195                 200                 205             


Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly 
    210                 215                 220                 


His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln 
225                 230                 235                 240 


Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg 
                245                 250                 255     


Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His 
            260                 265                 270         


Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln 
        275                 280                 285             


Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser 
    290                 295                 300                 


Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro 
                325                 330                 335     


Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser 
            340                 345                 350         


Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu 
        355                 360                 365             


Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp 
    370                 375                 380                 


Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala 
385                 390                 395                 400 


Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser 
                405                 410                 415     


Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly 
            420                 425                 430         


Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile 
        435                 440                 445             


Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln 
    450                 455                 460                 


Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr 
                485                 490                 495     


Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu 
            500                 505                 510         


Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu 
        515                 520                 525             


Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp 
    530                 535                 540                 


Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu 
545                 550                 555                 560 


Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile 
                565                 570                 575     


Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
            580                 585                 590         


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
        595                 600                 605             


Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu 
    610                 615                 620                 


Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val 
625                 630                 635                 640 


Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr 
                645                 650                 655     


Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro 
            660                 665                 670         


Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr 
        675                 680                 685             


Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn 
    690                 695                 700                 


Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu 
705                 710                 715                 720 


Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu 
                725                 730                 735     


Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro 
            740                 745                 750         


Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu 
        755                 760                 765             


Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
    770                 775                 780                 


Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
785                 790                 795                 800 


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro 
                805                 810                 815     


Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly 
            820                 825                 830         


Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr 
        835                 840                 845             


Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro 
    850                 855                 860                 


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
865                 870                 875                 880 


Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg 
                885                 890                 895     


Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu 
            900                 905                 910         


Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu 
        915                 920                 925             


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys 
    930                 935                 940                 


Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met 
945                 950                 955                 960 


Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu 
                965                 970                 975     


Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His 
            980                 985                 990         


Asn Val Trp Ala Arg Asp Arg Val  Gly Gln Gly Trp Ser  Tyr Ser Ala 
        995                 1000                 1005             


Val Gln  Asp Ile Pro Ala Arg  Arg Asn Pro Arg Leu  Val Pro Tyr 
    1010                 1015                 1020             


Arg Leu  Leu Asp Glu Ala Thr  Lys Arg Ser Asn Arg  Asp Ser Leu 
    1025                 1030                 1035             


Cys Gln  Ala Val Arg Thr Leu  Leu Gly Tyr Gly Tyr  Asn Ile Glu 
    1040                 1045                 1050             


Pro Pro  Asp Gln Glu Pro Ser  Gln Val Glu Asn Gln  Ser Arg Cys 
    1055                 1060                 1065             


Asp Arg  Val Arg Ile Phe Arg  Ala Glu Lys Ser Tyr  Thr Val Gln 
    1070                 1075                 1080             


Ser Gly  Arg Trp Tyr Phe Glu  Phe Glu Ala Val Thr  Thr Gly Glu 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Glu Leu Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Glu Leu Ala  Tyr Val Phe Asn Gly  His Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Leu Gly Ser  Glu Pro Phe Gly Arg  Pro Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asp Leu Thr  Glu Asn Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Asn Gly  Glu Val Leu Met Ser  Asp Ser Gly 
    1160                 1165                 1170             


Ser Glu  Thr Ala Phe Arg Glu  Ile Glu Ile Gly Asp  Gly Phe Leu 
    1175                 1180                 1185             


Pro Val  Cys Ser Leu Gly Pro  Gly Gln Val Gly His  Leu Asn Leu 
    1190                 1195                 1200             


Gly Gln  Asp Val Ser Ser Leu  Arg Phe Phe Ala Ile  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Ile Asn Met Gln  Arg Pro Val 
    1220                 1225                 1230             


Thr Thr  Trp Phe Ser Lys Gly  Leu Pro Gln Phe Glu  Pro Val Pro 
    1235                 1240                 1245             


Leu Glu  His Pro His Tyr Glu  Val Ser Arg Val Asp  Gly Thr Val 
    1250                 1255                 1260             


Asp Thr  Pro Pro Cys Leu Arg  Leu Thr His Arg Thr  Trp Gly Ser 
    1265                 1270                 1275             


Gln Asn  Ser Leu Val Glu Met  Leu Phe Leu Arg Leu  Ser Leu Pro 
    1280                 1285                 1290             


Val Gln  Phe His Gln His Phe  Arg Cys Thr Ala Gly  Ala Thr Pro 
    1295                 1300                 1305             


Leu Ala  Pro Pro Gly Leu Gln  Pro Pro Ala Glu Asp  Glu Ala Arg 
    1310                 1315                 1320             


Ala Ala  Glu Pro Asp Pro Asp  Tyr Glu Asn Leu Arg  Arg Ser Ala 
    1325                 1330                 1335             


Gly Gly  Trp Ser Glu Ala Glu  Asn Gly Lys Glu Gly  Thr Ala Lys 
    1340                 1345                 1350             


Glu Gly  Ala Pro Gly Gly Thr  Pro Gln Ala Gly Gly  Glu Ala Gln 
    1355                 1360                 1365             


Pro Ala  Arg Ala Glu Asn Glu  Lys Asp Ala Thr Thr  Glu Lys Asn 
    1370                 1375                 1380             


Lys Lys  Arg Gly Phe Leu Phe  Lys Ala Lys Lys Val  Ala Met Met 
    1385                 1390                 1395             


Thr Gln  Pro Pro Ala Thr Pro  Thr Leu Pro Arg Leu  Pro His Asp 
    1400                 1405                 1410             


Val Val  Pro Ala Asp Asn Arg  Asp Asp Pro Glu Ile  Ile Leu Asn 
    1415                 1420                 1425             


Thr Thr  Thr Tyr Tyr Tyr Ser  Val Arg Val Phe Ala  Gly Gln Glu 
    1430                 1435                 1440             


Pro Ser  Cys Val Trp Ala Gly  Trp Val Thr Pro Asp  Tyr His Gln 
    1445                 1450                 1455             


His Asp  Met Ser Phe Asp Leu  Ser Lys Val Arg Val  Val Thr Val 
    1460                 1465                 1470             


Thr Met  Gly Asp Glu Gln Gly  Asn Val His Ser Ser  Leu Lys Cys 
    1475                 1480                 1485             


Ser Asn  Cys Tyr Met Val Trp  Gly Gly Asp Phe Val  Ser Pro Gly 
    1490                 1495                 1500             


Gln Gln  Gly Arg Ile Ser His  Thr Asp Leu Val Ile  Gly Cys Leu 
    1505                 1510                 1515             


Val Asp  Leu Ala Thr Gly Leu  Met Thr Phe Thr Ala  Asn Gly Lys 
    1520                 1525                 1530             


Glu Ser  Asn Thr Phe Phe Gln  Val Glu Pro Asn Thr  Lys Leu Phe 
    1535                 1540                 1545             


Pro Ala  Val Phe Val Leu Pro  Thr His Gln Asn Val  Ile Gln Phe 
    1550                 1555                 1560             


Glu Leu  Gly Lys Gln Lys Asn  Ile Met Pro Leu Ser  Ala Ala Met 
    1565                 1570                 1575             


Phe Gln  Ser Glu Arg Lys Asn  Pro Ala Pro Gln Cys  Pro Pro Arg 
    1580                 1585                 1590             


Leu Glu  Met Gln Met Leu Met  Pro Val Ser Trp Ser  Arg Met Pro 
    1595                 1600                 1605             


Asn His  Phe Leu Gln Val Glu  Thr Arg Arg Ala Gly  Glu Arg Leu 
    1610                 1615                 1620             


Gly Trp  Ala Val Gln Cys Gln  Glu Pro Leu Thr Met  Met Ala Leu 
    1625                 1630                 1635             


His Ile  Pro Glu Glu Asn Arg  Cys Met Asp Ile Leu  Glu Leu Ser 
    1640                 1645                 1650             


Glu Arg  Leu Asp Leu Gln Arg  Phe His Ser His Thr  Leu Arg Leu 
    1655                 1660                 1665             


Tyr Arg  Ala Val Cys Ala Leu  Gly Asn Asn Arg Val  Ala His Ala 
    1670                 1675                 1680             


Leu Cys  Ser His Val Asp Gln  Ala Gln Leu Leu His  Ala Leu Glu 
    1685                 1690                 1695             


Asp Ala  His Leu Pro Gly Pro  Leu Arg Ala Gly Tyr  Tyr Asp Leu 
    1700                 1705                 1710             


Leu Ile  Ser Ile His Leu Glu  Ser Ala Cys Arg Ser  Arg Arg Ser 
    1715                 1720                 1725             


Met Leu  Ser Glu Tyr Ile Val  Pro Leu Thr Pro Glu  Thr Arg Ala 
    1730                 1735                 1740             


Ile Thr  Leu Phe Pro Pro Gly  Arg Ser Thr Glu Asn  Gly His Pro 
    1745                 1750                 1755             


Arg His  Gly Leu Pro Gly Val  Gly Val Thr Thr Ser  Leu Arg Pro 
    1760                 1765                 1770             


Pro His  His Phe Ser Pro Pro  Cys Phe Val Ala Ala  Leu Pro Ala 
    1775                 1780                 1785             


Ala Gly  Ala Ala Glu Ala Pro  Ala Arg Leu Ser Pro  Ala Ile Pro 
    1790                 1795                 1800             


Leu Glu  Ala Leu Arg Asp Lys  Ala Leu Arg Met Leu  Gly Glu Ala 
    1805                 1810                 1815             


Val Arg  Asp Gly Gly Gln His  Ala Arg Asp Pro Val  Gly Gly Ser 
    1820                 1825                 1830             


Val Glu  Phe Gln Phe Val Pro  Val Leu Lys Leu Val  Ser Thr Leu 
    1835                 1840                 1845             


Leu Val  Met Gly Ile Phe Gly  Asp Glu Asp Val Lys  Gln Ile Leu 
    1850                 1855                 1860             


Lys Met  Ile Glu Pro Glu Val  Phe Thr Glu Glu Glu  Glu Glu Glu 
    1865                 1870                 1875             


Asp Glu  Glu Glu Glu Gly Glu  Glu Glu Asp Glu Glu  Glu Lys Glu 
    1880                 1885                 1890             


Glu Asp  Glu Glu Glu Thr Ala  Gln Glu Lys Glu Asp  Glu Glu Lys 
    1895                 1900                 1905             


Glu Glu  Glu Glu Ala Ala Glu  Gly Glu Lys Glu Glu  Gly Leu Glu 
    1910                 1915                 1920             


Glu Gly  Leu Leu Gln Met Lys  Leu Pro Glu Ser Val  Lys Leu Gln 
    1925                 1930                 1935             


Met Cys  His Leu Leu Glu Tyr  Phe Cys Asp Gln Glu  Leu Gln His 
    1940                 1945                 1950             


Arg Val  Glu Ser Leu Ala Ala  Phe Ala Glu Arg Tyr  Val Asp Lys 
    1955                 1960                 1965             


Leu Gln  Ala Asn Gln Arg Ser  Arg Tyr Gly Leu Leu  Ile Lys Ala 
    1970                 1975                 1980             


Phe Ser  Met Thr Ala Ala Glu  Thr Ala Arg Arg Thr  Arg Glu Phe 
    1985                 1990                 1995             


Arg Ser  Pro Pro Gln Glu Gln  Ile Asn Met Leu Leu  Gln Phe Lys 
    2000                 2005                 2010             


Asp Gly  Thr Asp Glu Glu Asp  Cys Pro Leu Pro Glu  Glu Ile Arg 
    2015                 2020                 2025             


Gln Asp  Leu Leu Asp Phe His  Gln Asp Leu Leu Ala  His Cys Gly 
    2030                 2035                 2040             


Ile Gln  Leu Asp Gly Glu Glu  Glu Glu Pro Glu Glu  Glu Thr Thr 
    2045                 2050                 2055             


Leu Gly  Ser Arg Leu Met Ser  Leu Leu Glu Lys Val  Arg Leu Val 
    2060                 2065                 2070             


Lys Lys  Lys Glu Glu Lys Pro  Glu Glu Glu Arg Ser  Ala Glu Glu 
    2075                 2080                 2085             


Ser Lys  Pro Arg Ser Leu Gln  Glu Leu Val Ser His  Met Val Val 
    2090                 2095                 2100             


Arg Trp  Ala Gln Glu Asp Phe  Val Gln Ser Pro Glu  Leu Val Arg 
    2105                 2110                 2115             


Ala Met  Phe Ser Leu Leu His  Arg Gln Tyr Asp Gly  Leu Gly Glu 
    2120                 2125                 2130             


Leu Leu  Arg Ala Leu Pro Arg  Ala Tyr Thr Ile Ser  Pro Ser Ser 
    2135                 2140                 2145             


Val Glu  Asp Thr Met Ser Leu  Leu Glu Cys Leu Gly  Gln Ile Arg 
    2150                 2155                 2160             


Ser Leu  Leu Ile Val Gln Met  Gly Pro Gln Glu Glu  Asn Leu Met 
    2165                 2170                 2175             


Ile Gln  Ser Ile Gly Asn Ile  Met Asn Asn Lys Val  Phe Tyr Gln 
    2180                 2185                 2190             


His Pro  Asn Leu Met Arg Ala  Leu Gly Met His Glu  Thr Val Met 
    2195                 2200                 2205             


Glu Val  Met Val Asn Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile 
    2210                 2215                 2220             


Arg Phe  Pro Lys Met Val Thr  Ser Cys Cys Arg Phe  Leu Cys Tyr 
    2225                 2230                 2235             


Phe Cys  Arg Ile Ser Arg Gln  Asn Gln Arg Ser Met  Phe Asp His 
    2240                 2245                 2250             


Leu Ser  Tyr Leu Leu Glu Asn  Ser Gly Ile Gly Leu  Gly Met Gln 
    2255                 2260                 2265             


Gly Ser  Thr Pro Leu Asp Val  Ala Ala Ala Ser Val  Ile Asp Asn 
    2270                 2275                 2280             


Asn Glu  Leu Ala Leu Ala Leu  Gln Glu Gln Asp Leu  Glu Lys Val 
    2285                 2290                 2295             


Val Ser  Tyr Leu Ala Gly Cys  Gly Leu Gln Ser Cys  Pro Met Leu 
    2300                 2305                 2310             


Val Ala  Lys Gly Tyr Pro Asp  Ile Gly Trp Asn Pro  Cys Gly Gly 
    2315                 2320                 2325             


Glu Arg  Tyr Leu Asp Phe Leu  Arg Phe Ala Val Phe  Val Asn Gly 
    2330                 2335                 2340             


Glu Ser  Val Glu Glu Asn Ala  Asn Val Val Val Arg  Leu Leu Ile 
    2345                 2350                 2355             


Arg Lys  Pro Glu Cys Phe Gly  Pro Ala Leu Arg Gly  Glu Gly Gly 
    2360                 2365                 2370             


Ser Gly  Leu Leu Ala Ala Ile  Glu Glu Ala Ile Arg  Ile Ser Glu 
    2375                 2380                 2385             


Asp Pro  Ala Arg Asp Gly Pro  Gly Ile Arg Arg Asp  Arg Arg Arg 
    2390                 2395                 2400             


Glu His  Phe Gly Glu Glu Pro  Pro Glu Glu Asn Arg  Val His Leu 
    2405                 2410                 2415             


Gly His  Ala Ile Met Ser Phe  Tyr Ala Ala Leu Ile  Asp Leu Leu 
    2420                 2425                 2430             


Gly Arg  Cys Ala Pro Glu Met  His Leu Ile Gln Ala  Gly Lys Gly 
    2435                 2440                 2445             


Glu Ala  Leu Arg Ile Arg Ala  Ile Leu Arg Ser Leu  Val Pro Leu 
    2450                 2455                 2460             


Glu Asp  Leu Val Gly Ile Ile  Ser Leu Pro Leu Gln  Ile Pro Thr 
    2465                 2470                 2475             


Leu Gly  Lys Asp Gly Ala Leu  Val Gln Pro Lys Met  Ser Ala Ser 
    2480                 2485                 2490             


Phe Val  Pro Asp His Lys Ala  Ser Met Val Leu Phe  Leu Asp Arg 
    2495                 2500                 2505             


Val Tyr  Gly Ile Glu Asn Gln  Asp Phe Leu Leu His  Val Leu Asp 
    2510                 2515                 2520             


Val Gly  Phe Leu Pro Asp Met  Arg Ala Ala Ala Ser  Leu Asp Thr 
    2525                 2530                 2535             


Ala Thr  Phe Ser Thr Thr Glu  Met Ala Leu Ala Leu  Asn Arg Tyr 
    2540                 2545                 2550             


Leu Cys  Leu Ala Val Leu Pro  Leu Ile Thr Lys Cys  Ala Pro Leu 
    2555                 2560                 2565             


Phe Ala  Gly Thr Glu His Arg  Ala Ile Met Val Asp  Ser Met Leu 
    2570                 2575                 2580             


His Thr  Val Tyr Arg Leu Ser  Arg Gly Arg Ser Leu  Thr Lys Ala 
    2585                 2590                 2595             


Gln Arg  Asp Val Ile Glu Asp  Cys Leu Met Ser Leu  Cys Arg Tyr 
    2600                 2605                 2610             


Ile Arg  Pro Ser Met Leu Gln  His Leu Leu Arg Arg  Leu Val Phe 
    2615                 2620                 2625             


Asp Val  Pro Ile Leu Asn Glu  Phe Ala Lys Met Pro  Leu Lys Leu 
    2630                 2635                 2640             


Leu Thr  Asn His Tyr Glu Arg  Cys Trp Lys Tyr Tyr  Cys Leu Pro 
    2645                 2650                 2655             


Thr Gly  Trp Ala Asn Phe Gly  Val Thr Ser Glu Glu  Glu Leu His 
    2660                 2665                 2670             


Leu Thr  Arg Lys Leu Phe Trp  Gly Ile Phe Asp Ser  Leu Ala His 
    2675                 2680                 2685             


Lys Lys  Tyr Asp Pro Glu Leu  Tyr Arg Met Ala Met  Pro Cys Leu 
    2690                 2695                 2700             


Cys Ala  Ile Ala Gly Ala Leu  Pro Pro Asp Tyr Val  Asp Ala Ser 
    2705                 2710                 2715             


Tyr Ser  Ser Lys Ala Glu Lys  Lys Ala Thr Val Asp  Ala Glu Gly 
    2720                 2725                 2730             


Asn Phe  Asp Pro Arg Pro Val  Glu Thr Leu Asn Val  Ile Ile Pro 
    2735                 2740                 2745             


Glu Lys  Leu Asp Ser Phe Ile  Asn Lys Phe Ala Glu  Tyr Thr His 
    2750                 2755                 2760             


Glu Lys  Trp Ala Phe Asp Lys  Ile Gln Asn Asn Trp  Ser Tyr Gly 
    2765                 2770                 2775             


Glu Asn  Ile Asp Glu Glu Leu  Lys Thr His Pro Met  Leu Arg Pro 
    2780                 2785                 2790             


Tyr Lys  Thr Phe Ser Glu Lys  Asp Lys Glu Ile Tyr  Arg Trp Pro 
    2795                 2800                 2805             


Ile Lys  Glu Ser Leu Lys Ala  Met Ile Ala Trp Glu  Trp Thr Ile 
    2810                 2815                 2820             


Glu Lys  Ala Arg Glu Gly Glu  Glu Glu Lys Thr Glu  Lys Lys Lys 
    2825                 2830                 2835             


Thr Arg  Lys Ile Ser Gln Ser  Ala Gln Thr Tyr Asp  Pro Arg Glu 
    2840                 2845                 2850             


Gly Tyr  Asn Pro Gln Pro Pro  Asp Leu Ser Ala Val  Thr Leu Ser 
    2855                 2860                 2865             


Arg Glu  Leu Gln Ala Met Ala  Glu Gln Leu Ala Glu  Asn Tyr His 
    2870                 2875                 2880             


Asn Thr  Trp Gly Arg Lys Lys  Lys Gln Glu Leu Glu  Ala Lys Gly 
    2885                 2890                 2895             


Gly Gly  Thr His Pro Leu Leu  Val Pro Tyr Asp Thr  Leu Thr Ala 
    2900                 2905                 2910             


Lys Glu  Lys Ala Arg Asp Arg  Glu Lys Ala Gln Glu  Leu Leu Lys 
    2915                 2920                 2925             


Phe Leu  Gln Met Asn Gly Tyr  Ala Val Thr Arg Gly  Leu Lys Asp 
    2930                 2935                 2940             


Met Glu  Leu Asp Ser Ser Ser  Ile Glu Lys Arg Phe  Ala Phe Gly 
    2945                 2950                 2955             


Phe Leu  Gln Gln Leu Leu Arg  Trp Met Asp Ile Ser  Gln Glu Phe 
    2960                 2965                 2970             


Ile Ala  His Leu Glu Ala Val  Val Ser Ser Gly Arg  Val Glu Lys 
    2975                 2980                 2985             


Ser Pro  His Glu Gln Glu Ile  Lys Phe Phe Ala Lys  Ile Leu Leu 
    2990                 2995                 3000             


Pro Leu  Ile Asn Gln Tyr Phe  Thr Asn His Cys Leu  Tyr Phe Leu 
    3005                 3010                 3015             


Ser Thr  Pro Ala Lys Val Leu  Gly Ser Gly Gly His  Ala Ser Asn 
    3020                 3025                 3030             


Lys Glu  Lys Glu Met Ile Thr  Ser Leu Phe Cys Lys  Leu Ala Ala 
    3035                 3040                 3045             


Leu Val  Arg His Arg Val Ser  Leu Phe Gly Thr Asp  Ala Pro Ala 
    3050                 3055                 3060             


Val Val  Asn Cys Leu His Ile  Leu Ala Arg Ser Leu  Asp Ala Arg 
    3065                 3070                 3075             


Thr Val  Met Lys Ser Gly Pro  Glu Ile Val Lys Ala  Gly Leu Arg 
    3080                 3085                 3090             


Ser Phe  Phe Glu Ser Ala Ser  Glu Asp Ile Glu Lys  Met Val Glu 
    3095                 3100                 3105             


Asn Leu  Arg Leu Gly Lys Val  Ser Gln Ala Arg Thr  Gln Val Lys 
    3110                 3115                 3120             


Gly Val  Gly Gln Asn Leu Thr  Tyr Thr Thr Val Ala  Leu Leu Pro 
    3125                 3130                 3135             


Val Leu  Thr Thr Leu Phe Gln  His Ile Ala Gln His  Gln Phe Gly 
    3140                 3145                 3150             


Asp Asp  Val Ile Leu Asp Asp  Val Gln Val Ser Cys  Tyr Arg Thr 
    3155                 3160                 3165             


Leu Cys  Ser Ile Tyr Ser Leu  Gly Thr Thr Lys Asn  Thr Tyr Val 
    3170                 3175                 3180             


Glu Lys  Leu Arg Pro Ala Leu  Gly Glu Cys Leu Ala  Arg Leu Ala 
    3185                 3190                 3195             


Ala Ala  Met Pro Val Ala Phe  Leu Glu Pro Gln Leu  Asn Glu Tyr 
    3200                 3205                 3210             


Asn Ala  Cys Ser Val Tyr Thr  Thr Lys Ser Pro Arg  Glu Arg Ala 
    3215                 3220                 3225             


Ile Leu  Gly Leu Pro Asn Ser  Val Glu Glu Met Cys  Pro Asp Ile 
    3230                 3235                 3240             


Pro Val  Leu Glu Arg Leu Met  Ala Asp Ile Gly Gly  Leu Ala Glu 
    3245                 3250                 3255             


Ser Gly  Ala Arg Tyr Thr Glu  Met Pro His Val Ile  Glu Ile Thr 
    3260                 3265                 3270             


Leu Pro  Met Leu Cys Ser Tyr  Leu Pro Arg Trp Trp  Glu Arg Gly 
    3275                 3280                 3285             


Pro Glu  Ala Pro Pro Ser Ala  Leu Pro Ala Gly Ala  Pro Pro Pro 
    3290                 3295                 3300             


Cys Thr  Ala Val Thr Ser Asp  His Leu Asn Ser Leu  Leu Gly Asn 
    3305                 3310                 3315             


Ile Leu  Arg Ile Ile Val Asn  Asn Leu Gly Ile Asp  Glu Ala Ser 
    3320                 3325                 3330             


Trp Met  Lys Arg Leu Ala Val  Phe Ala Gln Pro Ile  Val Ser Arg 
    3335                 3340                 3345             


Ala Arg  Pro Glu Leu Leu Gln  Ser His Phe Ile Pro  Thr Ile Gly 
    3350                 3355                 3360             


Arg Leu  Arg Lys Arg Ala Gly  Lys Val Val Ser Glu  Glu Glu Gln 
    3365                 3370                 3375             


Leu Arg  Leu Glu Ala Lys Ala  Glu Ala Gln Glu Gly  Glu Leu Leu 
    3380                 3385                 3390             


Val Arg  Asp Glu Phe Ser Val  Leu Cys Arg Asp Leu  Tyr Ala Leu 
    3395                 3400                 3405             


Tyr Pro  Leu Leu Ile Arg Tyr  Val Asp Asn Asn Arg  Ala Gln Trp 
    3410                 3415                 3420             


Leu Thr  Glu Pro Asn Pro Ser  Ala Glu Glu Leu Phe  Arg Met Val 
    3425                 3430                 3435             


Gly Glu  Ile Phe Ile Tyr Trp  Ser Lys Ser His Asn  Phe Lys Arg 
    3440                 3445                 3450             


Glu Glu  Gln Asn Phe Val Val  Gln Asn Glu Ile Asn  Asn Met Ser 
    3455                 3460                 3465             


Phe Leu  Thr Ala Asp Asn Lys  Ser Lys Met Ala Lys  Ser Gly Gly 
    3470                 3475                 3480             


Ser Asp  Gln Glu Arg Thr Lys  Lys Lys Arg Arg Gly  Asp Arg Tyr 
    3485                 3490                 3495             


Ser Val  Gln Thr Ser Leu Ile  Val Ala Thr Leu Lys  Lys Met Leu 
    3500                 3505                 3510             


Pro Ile  Gly Leu Asn Met Cys  Ala Pro Thr Asp Gln  Asp Leu Ile 
    3515                 3520                 3525             


Thr Leu  Ala Lys Thr Arg Tyr  Ala Leu Lys Asp Thr  Asp Glu Glu 
    3530                 3535                 3540             


Val Arg  Glu Phe Leu His Asn  Asn Leu His Leu Gln  Gly Lys Val 
    3545                 3550                 3555             


Glu Gly  Ser Pro Ser Leu Arg  Trp Gln Met Ala Leu  Tyr Arg Gly 
    3560                 3565                 3570             


Val Pro  Gly Arg Glu Glu Asp  Ala Asp Asp Pro Glu  Lys Ile Val 
    3575                 3580                 3585             


Arg Arg  Val Gln Glu Val Ser  Ala Val Leu Tyr Tyr  Leu Asp Gln 
    3590                 3595                 3600             


Thr Glu  His Pro Tyr Lys Ser  Lys Lys Ala Val Trp  His Lys Leu 
    3605                 3610                 3615             


Leu Ser  Lys Gln Arg Arg Arg  Ala Val Val Ala Cys  Phe Arg Met 
    3620                 3625                 3630             


Thr Pro  Leu Tyr Asn Leu Pro  Thr His Arg Ala Cys  Asn Met Phe 
    3635                 3640                 3645             


Leu Glu  Ser Tyr Lys Ala Ala  Trp Ile Leu Thr Glu  Asp His Ser 
    3650                 3655                 3660             


Phe Glu  Asp Arg Met Ile Asp  Asp Leu Ser Lys Ala  Gly Glu Gln 
    3665                 3670                 3675             


Glu Glu  Glu Glu Glu Glu Val  Glu Glu Lys Lys Pro  Asp Pro Leu 
    3680                 3685                 3690             


His Gln  Leu Val Leu His Phe  Ser Arg Thr Ala Leu  Thr Glu Lys 
    3695                 3700                 3705             


Ser Lys  Leu Asp Glu Asp Tyr  Leu Tyr Met Ala Tyr  Ala Asp Ile 
    3710                 3715                 3720             


Met Ala  Lys Ser Cys His Leu  Glu Glu Gly Gly Glu  Asn Gly Glu 
    3725                 3730                 3735             


Ala Glu  Glu Glu Val Glu Val  Ser Phe Glu Glu Lys  Gln Met Glu 
    3740                 3745                 3750             


Lys Gln  Arg Leu Leu Tyr Gln  Gln Ala Arg Leu His  Thr Arg Gly 
    3755                 3760                 3765             


Ala Ala  Glu Met Val Leu Gln  Met Ile Ser Ala Cys  Lys Gly Glu 
    3770                 3775                 3780             


Thr Gly  Ala Met Val Ser Ser  Thr Leu Lys Leu Gly  Ile Ser Ile 
    3785                 3790                 3795             


Leu Asn  Gly Gly Asn Ala Glu  Val Gln Gln Lys Met  Leu Asp Tyr 
    3800                 3805                 3810             


Leu Lys  Asp Lys Lys Glu Val  Gly Phe Phe Gln Ser  Ile Gln Ala 
    3815                 3820                 3825             


Leu Met  Gln Thr Cys Ser Val  Leu Asp Leu Asn Ala  Phe Glu Arg 
    3830                 3835                 3840             


Gln Asn  Lys Ala Glu Gly Leu  Gly Met Val Asn Glu  Asp Gly Thr 
    3845                 3850                 3855             


Val Ile  Asn Arg Gln Asn Gly  Glu Lys Val Met Ala  Asp Asp Glu 
    3860                 3865                 3870             


Phe Thr  Gln Asp Leu Phe Arg  Phe Leu Gln Leu Leu  Cys Glu Gly 
    3875                 3880                 3885             


His Asn  Asn Asp Phe Gln Asn  Tyr Leu Arg Thr Gln  Thr Gly Asn 
    3890                 3895                 3900             


Thr Thr  Thr Ile Asn Ile Ile  Ile Cys Thr Val Asp  Tyr Leu Leu 
    3905                 3910                 3915             


Arg Leu  Gln Glu Ser Ile Ser  Asp Phe Tyr Trp Tyr  Tyr Ser Gly 
    3920                 3925                 3930             


Lys Asp  Val Ile Glu Glu Gln  Gly Lys Arg Asn Phe  Ser Lys Ala 
    3935                 3940                 3945             


Met Ser  Val Ala Lys Gln Val  Phe Asn Ser Leu Thr  Glu Tyr Ile 
    3950                 3955                 3960             


Gln Gly  Pro Cys Thr Gly Asn  Gln Gln Ser Leu Ala  His Ser Arg 
    3965                 3970                 3975             


Leu Trp  Asp Ala Val Val Gly  Phe Leu His Val Phe  Ala His Met 
    3980                 3985                 3990             


Met Met  Lys Leu Ala Gln Asp  Ser Ser Gln Ile Glu  Leu Leu Lys 
    3995                 4000                 4005             


Glu Leu  Leu Asp Leu Gln Lys  Asp Met Val Val Met  Leu Leu Ser 
    4010                 4015                 4020             


Leu Leu  Glu Gly Asn Val Val  Asn Gly Met Ile Ala  Arg Gln Met 
    4025                 4030                 4035             


Val Asp  Met Leu Val Glu Ser  Ser Ser Asn Val Glu  Met Ile Leu 
    4040                 4045                 4050             


Lys Phe  Phe Asp Met Phe Leu  Lys Leu Lys Asp Ile  Val Gly Ser 
    4055                 4060                 4065             


Glu Ala  Phe Gln Asp Tyr Val  Thr Asp Pro Arg Gly  Leu Ile Ser 
    4070                 4075                 4080             


Lys Lys  Asp Phe Gln Lys Ala  Met Asp Ser Gln Lys  Gln Phe Ser 
    4085                 4090                 4095             


Gly Pro  Glu Ile Gln Phe Leu  Leu Ser Cys Ser Glu  Ala Asp Glu 
    4100                 4105                 4110             


Asn Glu  Met Ile Asn Cys Glu  Glu Phe Ala Asn Arg  Phe Gln Glu 
    4115                 4120                 4125             


Pro Ala  Arg Asp Ile Gly Phe  Asn Val Ala Val Leu  Leu Thr Asn 
    4130                 4135                 4140             


Leu Ser  Glu His Val Pro His  Asp Pro Arg Leu His  Asn Phe Leu 
    4145                 4150                 4155             


Glu Leu  Ala Glu Ser Ile Leu  Glu Tyr Phe Arg Pro  Tyr Leu Gly 
    4160                 4165                 4170             


Arg Ile  Glu Ile Met Gly Ala  Ser Arg Arg Ile Glu  Arg Ile Tyr 
    4175                 4180                 4185             


Phe Glu  Ile Ser Glu Thr Asn  Arg Ala Gln Trp Glu  Met Pro Gln 
    4190                 4195                 4200             


Val Lys  Glu Ser Lys Arg Gln  Phe Ile Phe Asp Val  Val Asn Glu 
    4205                 4210                 4215             


Gly Gly  Glu Ala Glu Lys Met  Glu Leu Phe Val Ser  Phe Cys Glu 
    4220                 4225                 4230             


Asp Thr  Ile Phe Glu Met Gln  Ile Ala Ala Gln Ile  Ser Glu Pro 
    4235                 4240                 4245             


Glu Gly  Glu Pro Glu Thr Asp  Glu Asp Glu Gly Ala  Gly Ala Ala 
    4250                 4255                 4260             


Glu Ala  Gly Ala Glu Gly Ala  Glu Glu Gly Ala Ala  Gly Leu Glu 
    4265                 4270                 4275             


Gly Thr  Ala Ala Thr Ala Ala  Ala Gly Ala Thr Ala  Arg Val Val 
    4280                 4285                 4290             


Ala Ala  Ala Gly Arg Ala Leu  Arg Gly Leu Ser Tyr  Arg Ser Leu 
    4295                 4300                 4305             


Arg Arg  Arg Val Arg Arg Leu  Arg Arg Leu Thr Ala  Arg Glu Ala 
    4310                 4315                 4320             


Ala Thr  Ala Val Ala Ala Leu  Leu Trp Ala Ala Val  Thr Arg Ala 
    4325                 4330                 4335             


Gly Ala  Ala Gly Ala Gly Ala  Ala Ala Gly Ala Leu  Gly Leu Leu 
    4340                 4345                 4350             


Trp Gly  Ser Leu Phe Gly Gly  Gly Leu Val Glu Gly  Ala Lys Lys 
    4355                 4360                 4365             


Val Thr  Val Thr Glu Leu Leu  Ala Gly Met Pro Asp  Pro Thr Ser 
    4370                 4375                 4380             


Asp Glu  Val His Gly Glu Gln  Pro Ala Gly Pro Gly  Gly Asp Ala 
    4385                 4390                 4395             


Asp Gly  Glu Gly Ala Ser Glu  Gly Ala Gly Asp Ala  Ala Glu Gly 
    4400                 4405                 4410             


Ala Gly  Asp Glu Glu Glu Ala  Val His Glu Ala Gly  Pro Gly Gly 
    4415                 4420                 4425             


Ala Asp  Gly Ala Val Ala Val  Thr Asp Gly Gly Pro  Phe Arg Pro 
    4430                 4435                 4440             


Glu Gly  Ala Gly Gly Leu Gly  Asp Met Gly Asp Thr  Thr Pro Ala 
    4445                 4450                 4455             


Glu Pro  Pro Thr Pro Glu Gly  Ser Pro Ile Leu Lys  Arg Lys Leu 
    4460                 4465                 4470             


Gly Val  Asp Gly Val Glu Glu  Glu Leu Pro Pro Glu  Pro Glu Pro 
    4475                 4480                 4485             


Glu Pro  Glu Pro Glu Leu Glu  Pro Glu Lys Ala Asp  Ala Glu Asn 
    4490                 4495                 4500             


Gly Glu  Lys Glu Glu Val Pro  Glu Pro Thr Pro Glu  Pro Pro Lys 
    4505                 4510                 4515             


Lys Gln  Ala Pro Pro Ser Pro  Pro Pro Lys Lys Glu  Glu Ala Gly 
    4520                 4525                 4530             


Gly Glu  Phe Trp Gly Glu Leu  Glu Val Gln Arg Val  Lys Phe Leu 
    4535                 4540                 4545             


Asn Tyr  Leu Ser Arg Asn Phe  Tyr Thr Leu Arg Phe  Leu Ala Leu 
    4550                 4555                 4560             


Phe Leu  Ala Phe Ala Ile Asn  Phe Ile Leu Leu Phe  Tyr Lys Val 
    4565                 4570                 4575             


Ser Asp  Ser Pro Pro Gly Glu  Asp Asp Met Glu Gly  Ser Ala Ala 
    4580                 4585                 4590             


Gly Asp  Val Ser Gly Ala Gly  Ser Gly Gly Ser Ser  Gly Trp Gly 
    4595                 4600                 4605             


Leu Gly  Ala Gly Glu Glu Ala  Glu Gly Asp Glu Asp  Glu Asn Met 
    4610                 4615                 4620             


Val Tyr  Tyr Phe Leu Glu Glu  Ser Thr Gly Tyr Met  Glu Pro Ala 
    4625                 4630                 4635             


Leu Arg  Cys Leu Ser Leu Leu  His Thr Leu Val Ala  Phe Leu Cys 
    4640                 4645                 4650             


Ile Ile  Gly Tyr Asn Cys Leu  Lys Val Pro Leu Val  Ile Phe Lys 
    4655                 4660                 4665             


Arg Glu  Lys Glu Leu Ala Arg  Lys Leu Glu Phe Asp  Gly Leu Tyr 
    4670                 4675                 4680             


Ile Thr  Glu Gln Pro Glu Asp  Asp Asp Val Lys Gly  Gln Trp Asp 
    4685                 4690                 4695             


Arg Leu  Val Leu Asn Thr Pro  Ser Phe Pro Ser Asn  Tyr Trp Asp 
    4700                 4705                 4710             


Lys Phe  Val Lys Arg Lys Val  Leu Asp Lys His Gly  Asp Ile Tyr 
    4715                 4720                 4725             


Gly Arg  Glu Arg Ile Ala Glu  Leu Leu Gly Met Asp  Leu Ala Thr 
    4730                 4735                 4740             


Leu Glu  Ile Thr Ala His Asn  Glu Arg Lys Pro Asn  Pro Pro Pro 
    4745                 4750                 4755             


Gly Leu  Leu Thr Trp Leu Met  Ser Ile Asp Val Lys  Tyr Gln Ile 
    4760                 4765                 4770             


Trp Lys  Phe Gly Val Ile Phe  Thr Asp Asn Ser Phe  Leu Tyr Leu 
    4775                 4780                 4785             


Gly Trp  Tyr Met Val Met Ser  Leu Leu Gly His Tyr  Asn Asn Phe 
    4790                 4795                 4800             


Phe Phe  Ala Ala His Leu Leu  Asp Ile Ala Met Gly  Val Lys Thr 
    4805                 4810                 4815             


Leu Arg  Thr Ile Leu Ser Ser  Val Thr His Asn Gly  Lys Gln Leu 
    4820                 4825                 4830             


Val Met  Thr Val Gly Leu Leu  Ala Val Val Val Tyr  Leu Tyr Thr 
    4835                 4840                 4845             


Val Val  Ala Phe Asn Phe Phe  Arg Lys Phe Tyr Asn  Lys Ser Glu 
    4850                 4855                 4860             


Asp Glu  Asp Glu Pro Asp Met  Lys Cys Asp Asp Met  Met Thr Cys 
    4865                 4870                 4875             


Tyr Leu  Phe His Met Tyr Val  Gly Val Arg Ala Gly  Gly Gly Ile 
    4880                 4885                 4890             


Gly Asp  Glu Ile Glu Asp Pro  Ala Gly Asp Glu Tyr  Glu Leu Tyr 
    4895                 4900                 4905             


Arg Val  Val Phe Asp Ile Thr  Phe Phe Phe Phe Val  Ile Val Ile 
    4910                 4915                 4920             


Leu Leu  Ala Ile Ile Gln Gly  Leu Ile Ile Asp Ala  Phe Gly Glu 
    4925                 4930                 4935             


Leu Arg  Asp Gln Gln Glu Gln  Val Lys Glu Asp Met  Glu Thr Lys 
    4940                 4945                 4950             


Cys Phe  Ile Cys Gly Ile Gly  Ser Asp Tyr Phe Asp  Thr Thr Pro 
    4955                 4960                 4965             


His Gly  Phe Glu Thr His Thr  Leu Glu Glu His Asn  Leu Ala Asn 
    4970                 4975                 4980             


Tyr Met  Phe Phe Leu Met Tyr  Leu Ile Asn Lys Asp  Glu Thr Glu 
    4985                 4990                 4995             


His Thr  Gly Gln Glu Ser Tyr  Val Trp Lys Met Tyr  Gln Glu Arg 
    5000                 5005                 5010             


Cys Trp  Asp Phe Phe Pro Ala  Gly Asp Cys Phe Arg  Lys Gln Tyr 
    5015                 5020                 5025             


Glu Asp  Gln Leu Ser 
    5030             


<210>  20
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Pro Leu Phe Pro Ala Pro Phe Trp Glu Val Ile Tyr Gly Ser 
1               5                   10                  15      


His Leu Gln Gly Asn Leu Ser Leu Leu Ser Pro Asn His Ser Leu Leu 
            20                  25                  30          


Pro Pro His Leu Leu Leu Asn Ala Ser His Gly Ala Phe Leu Pro Leu 
        35                  40                  45              


Gly Leu Lys Val Thr Ile Val Gly Leu Tyr Leu Ala Val Cys Val Gly 
    50                  55                  60                  


Gly Leu Leu Gly Asn Cys Leu Val Met Tyr Val Ile Leu Arg His Thr 
65                  70                  75                  80  


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Thr Leu Val Leu Leu Thr Leu Pro Phe Gln Gly Thr Asp Ile Leu 
            100                 105                 110         


Leu Gly Phe Trp Pro Phe Gly Asn Ala Leu Cys Lys Thr Val Ile Ala 
        115                 120                 125             


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Thr Phe Thr Leu Thr Ala Met 
    130                 135                 140                 


Ser Val Asp Arg Tyr Val Ala Ile Cys His Pro Ile Arg Ala Leu Asp 
145                 150                 155                 160 


Val Arg Thr Ser Ser Lys Ala Gln Ala Val Asn Val Ala Ile Trp Ala 
                165                 170                 175     


Leu Ala Ser Val Val Gly Val Pro Val Ala Ile Met Gly Ser Ala Gln 
            180                 185                 190         


Val Glu Asp Glu Glu Ile Glu Cys Leu Val Glu Ile Pro Thr Pro Gln 
        195                 200                 205             


Asp Tyr Trp Gly Pro Val Phe Ala Ile Cys Ile Phe Leu Phe Ser Phe 
    210                 215                 220                 


Ile Val Pro Val Leu Val Ile Ser Val Cys Tyr Ser Leu Met Ile Arg 
225                 230                 235                 240 


Arg Leu Arg Gly Val Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg 
                245                 250                 255     


Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val Ala Val Phe 
            260                 265                 270         


Val Gly Cys Trp Thr Pro Val Gln Val Phe Val Leu Ala Gln Gly Leu 
        275                 280                 285             


Gly Val Gln Pro Ser Ser Glu Thr Ala Val Ala Ile Leu Arg Phe Cys 
    290                 295                 300                 


Thr Ala Leu Gly Tyr Val Asn Ser Cys Leu Asn Pro Ile Leu Tyr Ala 
305                 310                 315                 320 


Phe Leu Asp Glu Asn Phe Lys Ala Cys Phe Arg Lys Phe Cys Cys Ala 
                325                 330                 335     


Ser Ala Leu Arg Arg Asp Val Gln Val Ser Asp Arg Val Arg Ser Ile 
            340                 345                 350         


Ala Lys Asp Val Ala Leu Ala Cys Lys Thr Ser Glu Thr Val Pro Arg 
        355                 360                 365             


Pro Ala 
    370 


<210>  21
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Pro Leu Phe Pro Ala Pro Phe Trp Glu Val Ile Tyr Gly Ser 
1               5                   10                  15      


His Leu Gln Gly Asn Leu Ser Leu Leu Ser Pro Asn His Ser Leu Leu 
            20                  25                  30          


Pro Pro His Leu Leu Leu Asn Ala Ser His Gly Ala Phe Leu Pro Leu 
        35                  40                  45              


Gly Leu Lys Val Thr Ile Val Gly Leu Tyr Leu Ala Val Cys Val Gly 
    50                  55                  60                  


Gly Leu Leu Gly Asn Cys Leu Val Met Tyr Val Ile Leu Arg His Thr 
65                  70                  75                  80  


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Thr Leu Val Leu Leu Thr Leu Pro Phe Gln Gly Thr Asp Ile Leu 
            100                 105                 110         


Leu Gly Phe Trp Pro Phe Gly Asn Ala Leu Cys Lys Thr Val Ile Ala 
        115                 120                 125             


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Thr Phe Thr Leu Thr Ala Met 
    130                 135                 140                 


Ser Val Asp Arg Tyr Val Ala Ile Cys His Pro Ile Arg Ala Leu Asp 
145                 150                 155                 160 


Val Arg Thr Ser Ser Lys Ala Gln Ala Val Asn Val Ala Ile Trp Ala 
                165                 170                 175     


Leu Ala Ser Val Val Gly Val Pro Val Ala Ile Met Gly Ser Ala Gln 
            180                 185                 190         


Val Glu Asp Glu Glu Ile Glu Cys Leu Val Glu Ile Pro Thr Pro Gln 
        195                 200                 205             


Asp Tyr Trp Gly Pro Val Phe Ala Ile Cys Ile Phe Leu Phe Ser Phe 
    210                 215                 220                 


Ile Val Pro Val Leu Val Ile Ser Val Cys Tyr Ser Leu Met Ile Arg 
225                 230                 235                 240 


Arg Leu Arg Gly Val Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg 
                245                 250                 255     


Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val Ala Val Phe 
            260                 265                 270         


Val Gly Cys Trp Thr Pro Val Gln Val Phe Val Leu Ala Gln Gly Leu 
        275                 280                 285             


Gly Val Gln Pro Ser Ser Glu Thr Ala Val Ala Ile Leu Arg Phe Cys 
    290                 295                 300                 


Thr Ala Leu Gly Tyr Val Asn Ser Cys Leu Asn Pro Ile Leu Tyr Ala 
305                 310                 315                 320 


Phe Leu Asp Glu Asn Phe Lys Ala Cys Phe Arg Lys Phe Cys Cys Ala 
                325                 330                 335     


Ser Ala Leu Arg Arg Asp Val Gln Val Ser Asp Arg Val Arg Ser Ile 
            340                 345                 350         


Ala Lys Asp Val Ala Leu Ala Cys Lys Thr Ser Glu Thr Val Pro Arg 
        355                 360                 365             


Pro Ala 
    370 


<210>  22
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
        195                 200                 205             


His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
    210                 215                 220                 


Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
225                 230                 235                 240 


Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                245                 250                 255     


Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
            260                 265                 270         


Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
        275                 280                 285             


Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
    290                 295                 300                 


Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
305                 310                 315                 320 


Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                325                 330                 335     


Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
            340                 345                 350         


Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
        355                 360                 365             


Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
    370                 375                 380                 


Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
385                 390                 395                 400 


Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                405                 410                 415     


Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
            420                 425                 430         


Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
        435                 440                 445             


Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
    450                 455                 460                 


Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
465                 470                 475                 480 


Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                485                 490                 495     


Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
            500                 505                 510         


Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
        515                 520                 525             


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
    530                 535                 540                 


His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
545                 550                 555                 560 


Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                565                 570                 575     


Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
            580                 585                 590         


Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
        595                 600                 605             


Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
    610                 615                 620                 


Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
625                 630                 635                 640 


Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                645                 650                 655     


Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
            660                 665                 670         


Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
        675                 680                 685             


Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
    690                 695                 700                 


Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
705                 710                 715                 720 


Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                725                 730                 735     


Pro 
    


<210>  23
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Pro Gly Gln Leu Ala Leu Phe Ser Val Ser Asp Lys Thr Gly 
1               5                   10                  15      


Leu Val Glu Phe Ala Arg Asn Leu Thr Ala Leu Gly Leu Asn Leu Val 
            20                  25                  30          


Ala Ser Gly Gly Thr Ala Lys Ala Leu Arg Asp Ala Gly Leu Ala Val 
        35                  40                  45              


Arg Asp Val Ser Glu Leu Thr Gly Phe Pro Glu Met Leu Gly Gly Arg 
    50                  55                  60                  


Val Lys Thr Leu His Pro Ala Val His Ala Gly Ile Leu Ala Arg Asn 
65                  70                  75                  80  


Ile Pro Glu Asp Asn Ala Asp Met Ala Arg Leu Asp Phe Asn Leu Ile 
                85                  90                  95      


Arg Val Val Ala Cys Asn Leu Tyr Pro Phe Val Lys Thr Val Ala Ser 
            100                 105                 110         


Pro Gly Val Thr Val Glu Glu Ala Val Glu Gln Ile Asp Ile Gly Gly 
        115                 120                 125             


Val Thr Leu Leu Arg Ala Ala Ala Lys Asn His Ala Arg Val Thr Val 
    130                 135                 140                 


Val Cys Glu Pro Glu Asp Tyr Val Val Val Ser Thr Glu Met Gln Ser 
145                 150                 155                 160 


Ser Glu Ser Lys Asp Thr Ser Leu Glu Thr Arg Arg Gln Leu Ala Leu 
                165                 170                 175     


Lys Ala Phe Thr His Thr Ala Gln Tyr Asp Glu Ala Ile Ser Asp Tyr 
            180                 185                 190         


Phe Arg Lys Gln Tyr Ser Lys Gly Val Ser Gln Met Pro Leu Arg Tyr 
        195                 200                 205             


Gly Met Asn Pro His Gln Thr Pro Ala Gln Leu Tyr Thr Leu Gln Pro 
    210                 215                 220                 


Lys Leu Pro Ile Thr Val Leu Asn Gly Ala Pro Gly Phe Ile Asn Leu 
225                 230                 235                 240 


Cys Asp Ala Leu Asn Ala Trp Gln Leu Val Lys Glu Leu Lys Glu Ala 
                245                 250                 255     


Leu Gly Ile Pro Ala Ala Ala Ser Phe Lys His Val Ser Pro Ala Gly 
            260                 265                 270         


Ala Ala Val Gly Ile Pro Leu Ser Glu Asp Glu Ala Lys Val Cys Met 
        275                 280                 285             


Val Tyr Asp Leu Tyr Lys Thr Leu Thr Pro Ile Ser Ala Ala Tyr Ala 
    290                 295                 300                 


Arg Ala Arg Gly Ala Asp Arg Met Ser Ser Phe Gly Asp Phe Val Ala 
305                 310                 315                 320 


Leu Ser Asp Val Cys Asp Val Pro Thr Ala Lys Ile Ile Ser Arg Glu 
                325                 330                 335     


Val Ser Asp Gly Ile Ile Ala Pro Gly Tyr Glu Glu Glu Ala Leu Thr 
            340                 345                 350         


Ile Leu Ser Lys Lys Lys Asn Gly Asn Tyr Cys Val Leu Gln Met Asp 
        355                 360                 365             


Gln Ser Tyr Lys Pro Asp Glu Asn Glu Val Arg Thr Leu Phe Gly Leu 
    370                 375                 380                 


His Leu Ser Gln Lys Arg Asn Asn Gly Val Val Asp Lys Ser Leu Phe 
385                 390                 395                 400 


Ser Asn Val Val Thr Lys Asn Lys Asp Leu Pro Glu Ser Ala Leu Arg 
                405                 410                 415     


Asp Leu Ile Val Ala Thr Ile Ala Val Lys Tyr Thr Gln Ser Asn Ser 
            420                 425                 430         


Val Cys Tyr Ala Lys Asn Gly Gln Val Ile Gly Ile Gly Ala Gly Gln 
        435                 440                 445             


Gln Ser Arg Ile His Cys Thr Arg Leu Ala Gly Asp Lys Ala Asn Tyr 
    450                 455                 460                 


Trp Trp Leu Arg His His Pro Gln Val Leu Ser Met Lys Phe Lys Thr 
465                 470                 475                 480 


Gly Val Lys Arg Ala Glu Ile Ser Asn Ala Ile Asp Gln Tyr Val Thr 
                485                 490                 495     


Gly Thr Ile Gly Glu Asp Glu Asp Leu Ile Lys Trp Lys Ala Leu Phe 
            500                 505                 510         


Glu Glu Val Pro Glu Leu Leu Thr Glu Ala Glu Lys Lys Glu Trp Val 
        515                 520                 525             


Glu Lys Leu Thr Glu Val Ser Ile Ser Ser Asp Ala Phe Phe Pro Phe 
    530                 535                 540                 


Arg Asp Asn Val Asp Arg Ala Lys Arg Ser Gly Val Ala Tyr Ile Ala 
545                 550                 555                 560 


Ala Pro Ser Gly Ser Ala Ala Asp Lys Val Val Ile Glu Ala Cys Asp 
                565                 570                 575     


Glu Leu Gly Ile Ile Leu Ala His Thr Asn Leu Arg Leu Phe His His 
            580                 585                 590         


<210>  24
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gln Arg Gln Pro His Ser Pro Asn Gln Thr Leu Ile Ser Ile 
1               5                   10                  15      


Thr Asn Asp Thr Glu Ser Ser Ser Ser Val Val Ser Asn Asp Asn Thr 
            20                  25                  30          


Asn Lys Gly Trp Ser Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys 
        35                  40                  45              


Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly 
    50                  55                  60                  


Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr 
65                  70                  75                  80  


Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu 
                85                  90                  95      


Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly 
            100                 105                 110         


Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu 
        115                 120                 125             


Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp 
    130                 135                 140                 


Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala 
145                 150                 155                 160 


Ile Leu Lys Thr Cys Val Lys Ala Gly Cys Val Trp Ile Val Ser Met 
                165                 170                 175     


Ile Phe Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Arg 
            180                 185                 190         


Asp Pro Asn Lys Asn Met Thr Phe Glu Ser Cys Thr Ser Tyr Pro Val 
        195                 200                 205             


Ser Lys Lys Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val 
    210                 215                 220                 


Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile 
225                 230                 235                 240 


Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln 
                245                 250                 255     


Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Thr 
            260                 265                 270         


Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His 
        275                 280                 285             


Leu Leu Tyr Leu Tyr His Ser Phe Thr Ser Gln Thr Tyr Val Asp Pro 
    290                 295                 300                 


Ser Ala Met His Phe Ile Phe Thr Ile Phe Ser Arg Val Leu Ala Phe 
305                 310                 315                 320 


Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Ser 
                325                 330                 335     


Phe Gln Lys His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Arg 
            340                 345                 350         


Pro Glu Pro Pro Val Ala Asp Thr Ser Leu Thr Thr Leu Ala Val Met 
        355                 360                 365             


Gly Thr Val Pro Gly Thr Gly Ser Ile Gln Met Ser Glu Ile Ser Val 
    370                 375                 380                 


Thr Ser Phe Thr Gly Cys Ser Val Lys Gln Ala Glu Asp Arg Phe 
385                 390                 395                 


<210>  25
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Ser Cys Ser Arg Val Ala Leu Val Thr Gly Ala Asn Arg Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Ala Arg Glu Leu Cys Arg Gln Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Ala Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asn Val Leu Val Asn Asn Ala Ala Val Ala Phe Lys 
                85                  90                  95      


Ser Asp Asp Pro Met Pro Phe Asp Ile Lys Ala Glu Met Thr Leu Lys 
            100                 105                 110         


Thr Asn Phe Phe Ala Thr Arg Asn Met Cys Asn Glu Leu Leu Pro Ile 
        115                 120                 125             


Met Lys Pro His Gly Arg Val Val Asn Ile Ser Ser Leu Gln Cys Leu 
    130                 135                 140                 


Arg Ala Phe Glu Asn Cys Ser Glu Asp Leu Gln Glu Arg Phe His Ser 
145                 150                 155                 160 


Glu Thr Leu Thr Glu Gly Asp Leu Val Asp Leu Met Lys Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Asn Glu Val His Glu Arg Glu Gly Trp Pro Asn Ser 
            180                 185                 190         


Pro Tyr Gly Val Ser Lys Leu Gly Val Thr Val Leu Ser Arg Ile Leu 
        195                 200                 205             


Ala Arg Arg Leu Asp Glu Lys Arg Lys Ala Asp Arg Ile Leu Val Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Pro Val Lys Thr Asp Met Asp Gly Lys Asp Ser 
225                 230                 235                 240 


Ile Arg Thr Val Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Thr Glu Pro Gln Gly Gln Leu Val His Asp Lys 
            260                 265                 270         


Val Val Gln Asn Trp 
        275         


<210>  26
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Arg Pro Pro Gly Leu Arg Pro Gly Ala Gly Gly Pro Trp Glu 
1               5                   10                  15      


Met Arg Glu Arg Leu Gly Thr Gly Gly Phe Gly Asn Val Cys Leu Tyr 
            20                  25                  30          


Gln His Arg Glu Leu Asp Leu Lys Ile Ala Ile Lys Ser Cys Arg Leu 
        35                  40                  45              


Glu Leu Ser Thr Lys Asn Arg Glu Arg Trp Cys His Glu Ile Gln Ile 
    50                  55                  60                  


Met Lys Lys Leu Asn His Ala Asn Val Val Lys Ala Cys Asp Val Pro 
65                  70                  75                  80  


Glu Glu Leu Asn Ile Leu Ile His Asp Val Pro Leu Leu Ala Met Glu 
                85                  90                  95      


Tyr Cys Ser Gly Gly Asp Leu Arg Lys Leu Leu Asn Lys Pro Glu Asn 
            100                 105                 110         


Cys Cys Gly Leu Lys Glu Ser Gln Ile Leu Ser Leu Leu Ser Asp Ile 
        115                 120                 125             


Gly Ser Gly Ile Arg Tyr Leu His Glu Asn Lys Ile Ile His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Ile Val Leu Gln Asp Val Gly Gly Lys Ile Ile 
145                 150                 155                 160 


His Lys Ile Ile Asp Leu Gly Tyr Ala Lys Asp Val Asp Gln Gly Ser 
                165                 170                 175     


Leu Cys Thr Ser Phe Val Gly Thr Leu Gln Tyr Leu Ala Pro Glu Leu 
            180                 185                 190         


Phe Glu Asn Lys Pro Tyr Thr Ala Thr Val Asp Tyr Trp Ser Phe Gly 
        195                 200                 205             


Thr Met Val Phe Glu Cys Ile Ala Gly Tyr Arg Pro Phe Leu His His 
    210                 215                 220                 


Leu Gln Pro Phe Thr Trp His Glu Lys Ile Lys Lys Lys Asp Pro Lys 
225                 230                 235                 240 


Cys Ile Phe Ala Cys Glu Glu Met Ser Gly Glu Val Arg Phe Ser Ser 
                245                 250                 255     


His Leu Pro Gln Pro Asn Ser Leu Cys Ser Leu Val Val Glu Pro Met 
            260                 265                 270         


Glu Asn Trp Leu Gln Leu Met Leu Asn Trp Asp Pro Gln Gln Arg Gly 
        275                 280                 285             


Gly Pro Val Asp Leu Thr Leu Lys Gln Pro Arg Cys Phe Val Leu Met 
    290                 295                 300                 


Asp His Ile Leu Asn Leu Lys Ile Val His Ile Leu Asn Met Thr Ser 
305                 310                 315                 320 


Ala Lys Ile Ile Ser Phe Leu Leu Pro Pro Asp Glu Ser Leu His Ser 
                325                 330                 335     


Leu Gln Ser Arg Ile Glu Arg Glu Thr Gly Ile Asn Thr Gly Ser Gln 
            340                 345                 350         


Glu Leu Leu Ser Glu Thr Gly Ile Ser Leu Asp Pro Arg Lys Pro Ala 
        355                 360                 365             


Ser Gln Cys Val Leu Asp Gly Val Arg Gly Cys Asp Ser Tyr Met Val 
    370                 375                 380                 


Tyr Leu Phe Asp Lys Ser Lys Thr Val Tyr Glu Gly Pro Phe Ala Ser 
385                 390                 395                 400 


Arg Ser Leu Ser Asp Cys Val Asn Tyr Ile Val Gln Asp Ser Lys Ile 
                405                 410                 415     


Gln Leu Pro Ile Ile Gln Leu Arg Lys Val Trp Ala Glu Ala Val His 
            420                 425                 430         


Tyr Val Ser Gly Leu Lys Glu Asp Tyr Ser Arg Leu Phe Gln Gly Gln 
        435                 440                 445             


Arg Ala Ala Met Leu Ser Leu Leu Arg Tyr Asn Ala Asn Leu Thr Lys 
    450                 455                 460                 


Met Lys Asn Thr Leu Ile Ser Ala Ser Gln Gln Leu Lys Ala Lys Leu 
465                 470                 475                 480 


Glu Phe Phe His Lys Ser Ile Gln Leu Asp Leu Glu Arg Tyr Ser Glu 
                485                 490                 495     


Gln Met Thr Tyr Gly Ile Ser Ser Glu Lys Met Leu Lys Ala Trp Lys 
            500                 505                 510         


Glu Met Glu Glu Lys Ala Ile His Tyr Ala Glu Val Gly Val Ile Gly 
        515                 520                 525             


Tyr Leu Glu Asp Gln Ile Met Ser Leu His Ala Glu Ile Met Glu Leu 
    530                 535                 540                 


Gln Lys Ser Pro Tyr Gly Arg Arg Gln Gly Asp Leu Met Glu Ser Leu 
545                 550                 555                 560 


Glu Gln Arg Ala Ile Asp Leu Tyr Lys Gln Leu Lys His Arg Pro Ser 
                565                 570                 575     


Asp His Ser Tyr Ser Asp Ser Thr Glu Met Val Lys Ile Ile Val His 
            580                 585                 590         


Thr Val Gln Ser Gln Asp Arg Val Leu Lys Glu Leu Phe Gly His Leu 
        595                 600                 605             


Ser Lys Leu Leu Gly Cys Lys Gln Lys Ile Ile Asp Leu Leu Pro Lys 
    610                 615                 620                 


Val Glu Val Ala Leu Ser Asn Ile Lys Glu Ala Asp Asn Thr Val Met 
625                 630                 635                 640 


Phe Met Gln Gly Lys Arg Gln Lys Glu Ile Trp His Leu Leu Lys Ile 
                645                 650                 655     


Ala Cys Thr Gln Ser Ser Ala Arg Ser Leu Val Gly Ser Ser Leu Glu 
            660                 665                 670         


Gly Ala Val Thr Pro Gln Thr Ser Ala Trp Leu Pro Pro Thr Ser Ala 
        675                 680                 685             


Glu His Asp His Ser Leu Ser Cys Val Val Thr Pro Gln Asp Gly Glu 
    690                 695                 700                 


Thr Ser Ala Gln Met Ile Glu Glu Asn Leu Asn Cys Leu Gly His Leu 
705                 710                 715                 720 


Ser Thr Ile Ile His Glu Ala Asn Glu Glu Gln Gly Asn Ser Met Met 
                725                 730                 735     


Asn Leu Asp Trp Ser Trp Leu Thr Glu 
            740                 745 


<210>  27
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Thr Leu Pro Ala Ala Glu Thr Trp Ile Asp Gly Gly Gly Gly 
1               5                   10                  15      


Val Gly Ala Asp Ala Val Asn Leu Thr Ala Ser Leu Ala Ala Gly Ala 
            20                  25                  30          


Ala Thr Gly Ala Val Glu Thr Gly Trp Leu Gln Leu Leu Asp Gln Ala 
        35                  40                  45              


Gly Asn Leu Ser Ser Ser Pro Ser Ala Leu Gly Leu Pro Val Ala Ser 
    50                  55                  60                  


Pro Ala Pro Ser Gln Pro Trp Ala Asn Leu Thr Asn Gln Phe Val Gln 
65                  70                  75                  80  


Pro Ser Trp Arg Ile Ala Leu Trp Ser Leu Ala Tyr Gly Val Val Val 
                85                  90                  95      


Ala Val Ala Val Leu Gly Asn Leu Ile Val Ile Trp Ile Ile Leu Ala 
            100                 105                 110         


His Lys Arg Met Arg Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala 
        115                 120                 125             


Phe Ser Asp Ala Ser Met Ala Ala Phe Asn Thr Leu Val Asn Phe Ile 
    130                 135                 140                 


Tyr Ala Leu His Ser Glu Trp Tyr Phe Gly Ala Asn Tyr Cys Arg Phe 
145                 150                 155                 160 


Gln Asn Phe Phe Pro Ile Thr Ala Val Phe Ala Ser Ile Tyr Ser Met 
                165                 170                 175     


Thr Ala Ile Ala Val Asp Arg Tyr Met Ala Ile Ile Asp Pro Leu Lys 
            180                 185                 190         


Pro Arg Leu Ser Ala Thr Ala Thr Lys Ile Val Ile Gly Ser Ile Trp 
        195                 200                 205             


Ile Leu Ala Phe Leu Leu Ala Phe Pro Gln Cys Leu Tyr Ser Lys Thr 
    210                 215                 220                 


Lys Val Met Pro Gly Arg Thr Leu Cys Phe Val Gln Trp Pro Glu Gly 
225                 230                 235                 240 


Pro Lys Gln His Phe Thr Tyr His Ile Ile Val Ile Ile Leu Val Tyr 
                245                 250                 255     


Cys Phe Pro Leu Leu Ile Met Gly Ile Thr Tyr Thr Ile Val Gly Ile 
            260                 265                 270         


Thr Leu Trp Gly Gly Glu Ile Pro Gly Asp Thr Cys Asp Lys Tyr His 
        275                 280                 285             


Glu Gln Leu Lys Ala Lys Arg Lys Val Val Lys Met Met Ile Ile Val 
    290                 295                 300                 


Val Met Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Ile Tyr Phe Ile 
305                 310                 315                 320 


Leu Thr Ala Ile Tyr Gln Gln Leu Asn Arg Trp Lys Tyr Ile Gln Gln 
                325                 330                 335     


Val Tyr Leu Ala Ser Phe Trp Leu Ala Met Ser Ser Thr Met Tyr Asn 
            340                 345                 350         


Pro Ile Ile Tyr Cys Cys Leu Asn Lys Arg Phe Arg Ala Gly Phe Lys 
        355                 360                 365             


Arg Ala Phe Arg Trp Cys Pro Phe Ile Lys Val Ser Ser Tyr Asp Glu 
    370                 375                 380                 


Leu Glu Leu Lys Thr Thr Arg Phe His Pro Asn Arg Gln Ser Ser Met 
385                 390                 395                 400 


Tyr Thr Val Thr Arg Met Glu Ser Met Thr Val Val Phe Asp Pro Asn 
                405                 410                 415     


Asp Ala Asp Thr Thr Arg Ser Ser Arg Lys Lys Arg Ala Thr Pro Arg 
            420                 425                 430         


Asp Pro Ser Phe Asn Gly Cys Ser Arg Arg Asn Ser Lys Ser Ala Ser 
        435                 440                 445             


Ala Thr Ser Ser Phe Ile Ser Ser Pro Tyr Thr Ser Val Asp Glu Tyr 
    450                 455                 460                 


Ser 
465 


<210>  28
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  29
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Cys Phe Ser Phe Ile Met Pro Pro Ala Met Ala Asp Ile Leu Asp 
1               5                   10                  15      


Ile Trp Ala Val Asp Ser Gln Ile Ala Ser Asp Gly Ser Ile Pro Val 
            20                  25                  30          


Asp Phe Leu Leu Pro Thr Gly Ile Tyr Ile Gln Leu Glu Val Pro Arg 
        35                  40                  45              


Glu Ala Thr Ile Ser Tyr Ile Lys Gln Met Leu Trp Lys Gln Val His 
    50                  55                  60                  


Asn Tyr Pro Met Phe Asn Leu Leu Met Asp Ile Asp Ser Tyr Met Phe 
65                  70                  75                  80  


Ala Cys Val Asn Gln Thr Ala Val Tyr Glu Glu Leu Glu Asp Glu Thr 
                85                  90                  95      


Arg Arg Leu Cys Asp Val Arg Pro Phe Leu Pro Val Leu Lys Leu Val 
            100                 105                 110         


Thr Arg Ser Cys Asp Pro Gly Glu Lys Leu Asp Ser Lys Ile Gly Val 
        115                 120                 125             


Leu Ile Gly Lys Gly Leu His Glu Phe Asp Ser Leu Lys Asp Pro Glu 
    130                 135                 140                 


Val Asn Glu Phe Arg Arg Lys Met Arg Lys Phe Ser Glu Glu Lys Ile 
145                 150                 155                 160 


Leu Ser Leu Val Gly Leu Ser Trp Met Asp Trp Leu Lys Gln Thr Tyr 
                165                 170                 175     


Pro Pro Glu His Glu Pro Ser Ile Pro Glu Asn Leu Glu Asp Lys Leu 
            180                 185                 190         


Tyr Gly Gly Lys Leu Ile Val Ala Val His Phe Glu Asn Cys Gln Asp 
        195                 200                 205             


Val Phe Ser Phe Gln Val Ser Pro Asn Met Asn Pro Ile Lys Val Asn 
    210                 215                 220                 


Glu Leu Ala Ile Gln Lys Arg Leu Thr Ile His Gly Lys Glu Asp Glu 
225                 230                 235                 240 


Val Ser Pro Tyr Asp Tyr Val Leu Gln Val Ser Gly Arg Val Glu Tyr 
                245                 250                 255     


Val Phe Gly Asp His Pro Leu Ile Gln Phe Gln Tyr Ile Arg Asn Cys 
            260                 265                 270         


Val Met Asn Arg Ala Leu Pro His Phe Ile Leu Val Glu Cys Cys Lys 
        275                 280                 285             


Ile Lys Lys Met Tyr Glu Gln Glu Met Ile Ala Ile Glu Ala Ala Ile 
    290                 295                 300                 


Asn Arg Asn Ser Ser Asn Leu Pro Leu Pro Leu Pro Pro Lys Lys Thr 
305                 310                 315                 320 


Arg Ile Ile Ser His Val Trp Glu Asn Asn Asn Pro Phe Gln Ile Val 
                325                 330                 335     


Leu Val Lys Gly Asn Lys Leu Asn Thr Glu Glu Thr Val Lys Val His 
            340                 345                 350         


Val Arg Ala Gly Leu Phe His Gly Thr Glu Leu Leu Cys Lys Thr Ile 
        355                 360                 365             


Val Ser Ser Glu Val Ser Gly Lys Asn Asp His Ile Trp Asn Glu Pro 
    370                 375                 380                 


Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu Pro Arg Met Ala Arg Leu 
385                 390                 395                 400 


Cys Phe Ala Val Tyr Ala Val Leu Asp Lys Val Lys Thr Lys Lys Ser 
                405                 410                 415     


Thr Lys Thr Ile Asn Pro Ser Lys Tyr Gln Thr Ile Arg Lys Ala Gly 
            420                 425                 430         


Lys Val His Tyr Pro Val Ala Trp Val Asn Thr Met Val Phe Asp Phe 
        435                 440                 445             


Lys Gly Gln Leu Arg Thr Gly Asp Ile Ile Leu His Ser Trp Ser Ser 
    450                 455                 460                 


Phe Pro Asp Glu Leu Glu Glu Met Leu Asn Pro Met Gly Thr Val Gln 
465                 470                 475                 480 


Thr Asn Pro Tyr Thr Glu Asn Ala Thr Ala Leu His Val Lys Phe Pro 
                485                 490                 495     


Glu Asn Lys Lys Gln Pro Tyr Tyr Tyr Pro Pro Phe Asp Lys Ile Ile 
            500                 505                 510         


Glu Lys Ala Ala Glu Ile Ala Ser Ser Asp Ser Ala Asn Val Ser Ser 
        515                 520                 525             


Arg Gly Gly Lys Lys Phe Leu Pro Val Leu Lys Glu Ile Leu Asp Arg 
    530                 535                 540                 


Asp Pro Leu Ser Gln Leu Cys Glu Asn Glu Met Asp Leu Ile Trp Thr 
545                 550                 555                 560 


Leu Arg Gln Asp Cys Arg Glu Ile Phe Pro Gln Ser Leu Pro Lys Leu 
                565                 570                 575     


Leu Leu Ser Ile Lys Trp Asn Lys Leu Glu Asp Val Ala Gln Leu Gln 
            580                 585                 590         


Ala Leu Leu Gln Ile Trp Pro Lys Leu Pro Pro Arg Glu Ala Leu Glu 
        595                 600                 605             


Leu Leu Asp Phe Asn Tyr Pro Asp Gln Tyr Val Arg Glu Tyr Ala Val 
    610                 615                 620                 


Gly Cys Leu Arg Gln Met Ser Asp Glu Glu Leu Ser Gln Tyr Leu Leu 
625                 630                 635                 640 


Gln Leu Val Gln Val Leu Lys Tyr Glu Pro Phe Leu Asp Cys Ala Leu 
                645                 650                 655     


Ser Arg Phe Leu Leu Glu Arg Ala Leu Gly Asn Arg Arg Ile Gly Gln 
            660                 665                 670         


Phe Leu Phe Trp His Leu Arg Ser Glu Val His Ile Pro Ala Val Ser 
        675                 680                 685             


Val Gln Phe Gly Val Ile Leu Glu Ala Tyr Cys Arg Gly Ser Val Gly 
    690                 695                 700                 


His Met Lys Val Leu Ser Lys Gln Val Glu Ala Leu Asn Lys Leu Lys 
705                 710                 715                 720 


Thr Leu Asn Ser Leu Ile Lys Leu Asn Ala Val Lys Leu Asn Arg Ala 
                725                 730                 735     


Lys Gly Lys Glu Ala Met His Thr Cys Leu Lys Gln Ser Ala Tyr Arg 
            740                 745                 750         


Glu Ala Leu Ser Asp Leu Gln Ser Pro Leu Asn Pro Cys Val Ile Leu 
        755                 760                 765             


Ser Glu Leu Tyr Val Glu Lys Cys Lys Tyr Met Asp Ser Lys Met Lys 
    770                 775                 780                 


Pro Leu Trp Leu Val Tyr Asn Asn Lys Val Phe Gly Glu Asp Ser Val 
785                 790                 795                 800 


Gly Val Ile Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr 
                805                 810                 815     


Leu Gln Met Leu Arg Leu Met Asp Leu Leu Trp Lys Glu Ala Gly Leu 
            820                 825                 830         


Asp Leu Arg Met Leu Pro Tyr Gly Cys Leu Ala Thr Gly Asp Arg Ser 
        835                 840                 845             


Gly Leu Ile Glu Val Val Ser Thr Ser Glu Thr Ile Ala Asp Ile Gln 
    850                 855                 860                 


Leu Asn Ser Ser Asn Val Ala Ala Ala Ala Ala Phe Asn Lys Asp Ala 
865                 870                 875                 880 


Leu Leu Asn Trp Leu Lys Glu Tyr Asn Ser Gly Asp Asp Leu Asp Arg 
                885                 890                 895     


Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala Gly Tyr Cys Val Ala Ser 
            900                 905                 910         


Tyr Val Leu Gly Ile Gly Asp Arg His Ser Asp Asn Ile Met Val Lys 
        915                 920                 925             


Lys Thr Gly Gln Leu Phe His Ile Asp Phe Gly His Ile Leu Gly Asn 
    930                 935                 940                 


Phe Lys Ser Lys Phe Gly Ile Lys Arg Glu Arg Val Pro Phe Ile Leu 
945                 950                 955                 960 


Thr Tyr Asp Phe Ile His Val Ile Gln Gln Gly Lys Thr Gly Asn Thr 
                965                 970                 975     


Glu Lys Phe Gly Arg Phe Arg Gln Cys Cys Glu Asp Ala Tyr Leu Ile 
            980                 985                 990         


Leu Arg Arg His Gly Asn Leu Phe  Ile Thr Leu Phe Ala  Leu Met Leu 
        995                 1000                 1005             


Thr Ala  Gly Leu Pro Glu Leu  Thr Ser Val Lys Asp  Ile Gln Tyr 
    1010                 1015                 1020             


Leu Lys  Asp Ser Leu Ala Leu  Gly Lys Ser Glu Glu  Glu Ala Leu 
    1025                 1030                 1035             


Lys Gln  Phe Lys Gln Lys Phe  Asp Glu Ala Leu Arg  Glu Ser Trp 
    1040                 1045                 1050             


Thr Thr  Lys Val Asn Trp Met  Ala His Thr Val Arg  Lys Asp Tyr 
    1055                 1060                 1065             


Arg Ser  
    1070 


<210>  30
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Val Asp Met Gly Ala Leu Asp Asn Leu Ile Ala Asn Thr Ala Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Lys Pro Ser Asp Cys Asp Ser Lys Glu Leu Gln Arg 
            20                  25                  30          


Arg Arg Arg Ser Leu Ala Leu Pro Gly Leu Gln Gly Cys Ala Glu Leu 
        35                  40                  45              


Arg Gln Lys Leu Ser Leu Asn Phe His Ser Leu Cys Glu Gln Gln Pro 
    50                  55                  60                  


Ile Gly Arg Arg Leu Phe Arg Asp Phe Leu Ala Thr Val Pro Thr Phe 
65                  70                  75                  80  


Arg Lys Ala Ala Thr Phe Leu Glu Asp Val Gln Asn Trp Glu Leu Ala 
                85                  90                  95      


Glu Glu Gly Pro Thr Lys Asp Ser Ala Leu Gln Gly Leu Val Ala Thr 
            100                 105                 110         


Cys Ala Ser Ala Pro Ala Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln 
        115                 120                 125             


Ala Val Ala Thr Lys Cys Gln Ala Ala Thr Thr Glu Glu Glu Arg Val 
    130                 135                 140                 


Ala Ala Val Thr Leu Ala Lys Ala Glu Ala Met Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Gln Pro Phe Lys Asp Phe Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu 
                165                 170                 175     


Gln Trp Lys Leu Phe Glu Met Gln Pro Val Ser Asp Lys Tyr Phe Thr 
            180                 185                 190         


Glu Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Val 
        195                 200                 205             


Gln Val Lys Asn Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Leu Lys Lys Lys Gly Gly Glu Lys Met Ala Leu Leu Glu Lys 
225                 230                 235                 240 


Glu Ile Leu Glu Lys Val Ser Ser Pro Phe Ile Val Ser Leu Ala Tyr 
                245                 250                 255     


Ala Phe Glu Ser Lys Thr His Leu Cys Leu Val Met Ser Leu Met Asn 
            260                 265                 270         


Gly Gly Asp Leu Lys Phe His Ile Tyr Asn Val Gly Thr Arg Gly Leu 
        275                 280                 285             


Asp Met Ser Arg Val Ile Phe Tyr Ser Ala Gln Ile Ala Cys Gly Met 
    290                 295                 300                 


Leu His Leu His Glu Leu Gly Ile Val Tyr Arg Asp Met Lys Pro Glu 
305                 310                 315                 320 


Asn Val Leu Leu Asp Asp Leu Gly Asn Cys Arg Leu Ser Asp Leu Gly 
                325                 330                 335     


Leu Ala Val Glu Met Lys Gly Gly Lys Pro Ile Thr Gln Arg Ala Gly 
            340                 345                 350         


Thr Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys Val Ser Tyr 
        355                 360                 365             


Ser Tyr Pro Val Asp Trp Phe Ala Met Gly Cys Ser Ile Tyr Glu Met 
    370                 375                 380                 


Val Ala Gly Arg Thr Pro Phe Lys Asp Tyr Lys Glu Lys Val Ser Lys 
385                 390                 395                 400 


Glu Asp Leu Lys Gln Arg Thr Leu Gln Asp Glu Val Lys Phe Gln His 
                405                 410                 415     


Asp Asn Phe Thr Glu Glu Ala Lys Asp Ile Cys Arg Leu Phe Leu Ala 
            420                 425                 430         


Lys Lys Pro Glu Gln Arg Leu Gly Ser Arg Glu Lys Ser Asp Asp Pro 
        435                 440                 445             


Arg Lys His His Phe Phe Lys Thr Ile Asn Phe Pro Arg Leu Glu Ala 
    450                 455                 460                 


Gly Leu Ile Glu Pro Pro Phe Val Pro Asp Pro Ser Val Val Tyr Ala 
465                 470                 475                 480 


Lys Asp Ile Ala Glu Ile Asp Asp Phe Ser Glu Val Arg Gly Val Glu 
                485                 490                 495     


Phe Asp Asp Lys Asp Lys Gln Phe Phe Lys Asn Phe Ala Thr Gly Ala 
            500                 505                 510         


Val Pro Ile Ala Trp Gln Glu Glu Ile Ile Glu Thr Gly Leu Phe Glu 
        515                 520                 525             


Glu Leu Asn Asp Pro Asn Arg Pro Thr Gly Cys Glu Glu Gly Asn Ser 
    530                 535                 540                 


Ser Lys Ser Gly Val Cys Leu Leu Leu 
545                 550             


<210>  31
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His 
            260                 265                 270         


Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
        275                 280                 285             


Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln 
    290                 295                 300                 


Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln 
305                 310                 315                 320 


Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu 
                325                 330                 335     


Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg 
            340                 345                 350         


Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser 
        355                 360                 365             


Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp 
    370                 375                 380                 


Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu 
385                 390                 395                 400 


Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met 
                405                 410                 415     


Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro 
            420                 425                 430         


His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly 
        435                 440                 445             


Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro 
    450                 455                 460                 


Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro 
465                 470                 475                 480 


Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly 
                485                 490                 495     


Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly 
            500                 505                 510         


Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
        515                 520                 525             


Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly 
    530                 535                 540                 


Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala 
                565                 570                 575     


Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys 
            580                 585                 590         


Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val 
        595                 600                 605             


Gln Glu Gln Gly Gly Ala Lys Ala 
    610                 615     


<210>  32
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Pro Val Gln Pro Ala Glu Pro Pro Glu Val Leu Lys Ser Glu 
1               5                   10                  15      


Pro Tyr Gly Glu Lys Ala Asp Val Trp Ala Val Gly Cys Ile Leu Tyr 
            20                  25                  30          


Gln Met Ala Thr Leu Ser Pro Pro Phe Tyr Ser Thr Asn Met Leu Ser 
        35                  40                  45              


Leu Ala Thr Lys Ile Val Glu Ala Val Tyr Glu Pro Val Pro Glu Gly 
    50                  55                  60                  


Ile Tyr Ser Glu Lys Val Thr Asp Thr Ile Ser Arg Cys Leu Thr Pro 
65                  70                  75                  80  


Asp Ala Glu Ala Arg Pro Asp Ile Val Glu Val Ser Ser Met Ile Ser 
                85                  90                  95      


Asp Val Met Met Lys Tyr Leu Asp Asn Leu Ser Thr Ser Gln Leu Ser 
            100                 105                 110         


Leu Glu Lys Lys Leu Glu Arg Glu Arg Arg Arg Thr Gln Arg Tyr Phe 
        115                 120                 125             


Met Glu Ala Asn Arg Asn Thr Val Thr Cys His His Glu Leu Ala Val 
    130                 135                 140                 


Leu Ser His Glu Thr Phe Glu Lys Ala Ser Leu Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Ala Ala Ser Leu Lys Ser Glu Leu Ser Glu Ser Ala Asp Leu Pro 
                165                 170                 175     


Pro Glu Gly Phe Gln Ala Ser Tyr Gly Lys Asp Glu Asp Arg Ala Cys 
            180                 185                 190         


Asp Glu Ile Leu Ser Asp Asp Asn Phe Asn Leu Glu Asn Ala Glu Lys 
        195                 200                 205             


Asp Thr Tyr Ser Glu Val Asp Asp Glu Leu Asp Ile Ser Asp Asn Ser 
    210                 215                 220                 


Ser Ser Ser Ser Ser Ser Pro Leu Lys Glu Ser Thr Phe Asn Ile Leu 
225                 230                 235                 240 


Lys Arg Ser Phe Ser Ala Ser Gly Gly Glu Arg Gln Ser Gln Thr Arg 
                245                 250                 255     


Asp Phe Thr Gly Gly Thr Gly Ser Arg Pro Arg Pro Ala Leu Leu Pro 
            260                 265                 270         


Leu Asp Leu Leu Leu Lys Val Pro Pro His Met Leu Arg Ala His Ile 
        275                 280                 285             


Lys Glu Ile Glu Ala Glu Leu Val Thr Gly Trp Gln Ser His Ser Leu 
    290                 295                 300                 


Pro Ala Val Ile Leu Arg Asn Leu Lys Asp His Ala Ser Ala Gly Ile 
305                 310                 315                 320 


Ala Val Ser Gln Arg Lys Val Arg Gln Ile Ser Asp Pro Ile Gln Gln 
                325                 330                 335     


Ile Leu Ile Gln Leu His Lys Ile Ile Tyr Ile Thr Gln Leu Pro Pro 
            340                 345                 350         


Ala Leu His His Asn Leu Lys Arg Arg Val Ile Glu Arg Phe Lys Lys 
        355                 360                 365             


Ser Leu Phe Ser Gln Gln Ser Asn Pro Cys Asn Leu Lys Ser Glu Ile 
    370                 375                 380                 


Lys Lys Leu Ser Gln Gly Ser Pro Glu Pro Ile Glu Pro Asn Phe Phe 
385                 390                 395                 400 


Thr Ala Asp Tyr His Leu Leu His Arg Ser Ser Gly Gly Asn Ser Leu 
                405                 410                 415     


Ser Pro Asn Asp Pro Thr Gly Leu Pro Thr Ser Ile Glu Leu Glu Glu 
            420                 425                 430         


Gly Ile Thr Tyr Glu Gln Met Gln Thr Val Ile Glu Glu Val Leu Glu 
        435                 440                 445             


Glu Ser Gly Tyr Tyr Asn Phe Thr Ser Asn Arg Tyr His Ser Tyr Pro 
    450                 455                 460                 


Trp Gly Thr Lys Asn His Pro Thr Lys Arg 
465                 470                 


<210>  33
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  34
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Val Ile Met Ser Glu Phe Ser Ala Asp Pro Ala Gly Gln Gly Gln 
1               5                   10                  15      


Gly Gln Gln Lys Pro Leu Arg Val Gly Phe Tyr Asp Ile Glu Arg Thr 
            20                  25                  30          


Leu Gly Lys Gly Asn Phe Ala Val Val Lys Leu Ala Arg His Arg Val 
        35                  40                  45              


Thr Lys Thr Gln Val Ala Ile Lys Ile Ile Asp Lys Thr Arg Leu Asp 
    50                  55                  60                  


Ser Ser Asn Leu Glu Lys Ile Tyr Arg Glu Val Gln Leu Met Lys Leu 
65                  70                  75                  80  


Leu Asn His Pro His Ile Ile Lys Leu Tyr Gln Val Met Glu Thr Lys 
                85                  90                  95      


Asp Met Leu Tyr Ile Val Thr Glu Phe Ala Lys Asn Gly Glu Met Phe 
            100                 105                 110         


Asp Tyr Leu Thr Ser Asn Gly His Leu Ser Glu Asn Glu Ala Arg Lys 
        115                 120                 125             


Lys Phe Trp Gln Ile Leu Ser Ala Val Glu Tyr Cys His Asp His His 
    130                 135                 140                 


Ile Val His Arg Asp Leu Lys Thr Glu Asn Leu Leu Leu Asp Gly Asn 
145                 150                 155                 160 


Met Asp Ile Lys Leu Ala Asp Phe Gly Phe Gly Asn Phe Tyr Lys Ser 
                165                 170                 175     


Gly Glu Pro Leu Ser Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro 
            180                 185                 190         


Glu Val Phe Glu Gly Lys Glu Tyr Glu Gly Pro Gln Leu Asp Ile Trp 
        195                 200                 205             


Ser Leu Gly Val Val Leu Tyr Val Leu Val Cys Gly Ser Leu Pro Phe 
    210                 215                 220                 


Asp Gly Pro Asn Leu Pro Thr Leu Arg Gln Arg Val Leu Glu Gly Arg 
225                 230                 235                 240 


Phe Arg Ile Pro Phe Phe Met Ser Gln Asp Cys Glu Ser Leu Ile Arg 
                245                 250                 255     


Arg Met Leu Val Val Asp Pro Ala Arg Arg Ile Thr Ile Ala Gln Ile 
            260                 265                 270         


Arg Gln His Arg Trp Met Arg Ala Glu Pro Cys Leu Pro Gly Pro Ala 
        275                 280                 285             


Cys Pro Ala Phe Ser Ala His Ser Tyr Thr Ser Asn Leu Gly Asp Tyr 
    290                 295                 300                 


Asp Glu Gln Ala Leu Gly Ile Met Gln Thr Leu Gly Val Asp Arg Gln 
305                 310                 315                 320 


Arg Thr Val Glu Ser Leu Gln Asn Ser Ser Tyr Asn His Phe Ala Ala 
                325                 330                 335     


Ile Tyr Tyr Leu Leu Leu Glu Arg Leu Lys Glu Tyr Arg Asn Ala Gln 
            340                 345                 350         


Cys Ala Arg Pro Gly Pro Ala Arg Gln Pro Arg Pro Arg Ser Ser Asp 
        355                 360                 365             


Leu Ser Gly Leu Glu Val Pro Gln Glu Gly Leu Ser Thr Asp Pro Phe 
    370                 375                 380                 


Arg Pro Ala Leu Leu Cys Pro Gln Pro Gln Thr Leu Val Gln Ser Val 
385                 390                 395                 400 


Leu Gln Ala Glu Met Asp Cys Glu Leu Gln Ser Ser Leu Gln Trp Pro 
                405                 410                 415     


Leu Phe Phe Pro Val Asp Ala Ser Cys Ser Gly Val Phe Arg Pro Arg 
            420                 425                 430         


Pro Val Ser Pro Ser Ser Leu Leu Asp Thr Ala Ile Ser Glu Glu Ala 
        435                 440                 445             


Arg Gln Gly Pro Gly Leu Glu Glu Glu Gln Asp Thr Gln Glu Ser Leu 
    450                 455                 460                 


Pro Ser Ser Thr Gly Arg Arg His Thr Leu Ala Glu Val Ser Thr Arg 
465                 470                 475                 480 


Leu Ser Pro Leu Thr Ala Pro Cys Ile Val Val Ser Pro Ser Thr Thr 
                485                 490                 495     


Ala Ser Pro Ala Glu Gly Thr Ser Ser Asp Ser Cys Leu Thr Phe Ser 
            500                 505                 510         


Ala Ser Lys Ser Pro Ala Gly Leu Ser Gly Thr Pro Ala Thr Gln Gly 
        515                 520                 525             


Leu Leu Gly Ala Cys Ser Pro Val Arg Leu Ala Ser Pro Phe Leu Gly 
    530                 535                 540                 


Ser Gln Ser Ala Thr Pro Val Leu Gln Ala Gln Gly Gly Leu Gly Gly 
545                 550                 555                 560 


Ala Val Leu Leu Pro Val Ser Phe Gln Glu Gly Arg Arg Ala Ser Asp 
                565                 570                 575     


Thr Ser Leu Thr Gln Gly Leu Lys Ala Phe Arg Gln Gln Leu Arg Lys 
            580                 585                 590         


Thr Thr Arg Thr Lys Gly Phe Leu Gly Leu Asn Lys Ile Lys Gly Leu 
        595                 600                 605             


Ala Arg Gln Val Cys Gln Ala Pro Ala Ser Arg Ala Ser Arg Gly Gly 
    610                 615                 620                 


Leu Ser Pro Phe His Ala Pro Ala Gln Ser Pro Gly Leu His Gly Gly 
625                 630                 635                 640 


Ala Ala Gly Ser Arg Glu Gly Trp Ser Leu Leu Glu Glu Val Leu Glu 
                645                 650                 655     


Gln Gln Arg Leu Leu Gln Leu Gln His His Pro Ala Ala Ala Pro Gly 
            660                 665                 670         


Cys Ser Gln Ala Pro Gln Pro Ala Pro Ala Pro Phe Val Ile Ala Pro 
        675                 680                 685             


Cys Asp Gly Pro Gly Ala Ala Pro Leu Pro Ser Thr Leu Leu Thr Ser 
    690                 695                 700                 


Gly Leu Pro Leu Leu Pro Pro Pro Leu Leu Gln Thr Gly Ala Ser Pro 
705                 710                 715                 720 


Val Ala Ser Ala Ala Gln Leu Leu Asp Thr His Leu His Ile Gly Thr 
                725                 730                 735     


Gly Pro Thr Ala Leu Pro Ala Val Pro Pro Pro Arg Leu Ala Arg Leu 
            740                 745                 750         


Ala Pro Gly Cys Glu Pro Leu Gly Leu Leu Gln Gly Asp Cys Glu Met 
        755                 760                 765             


Glu Asp Leu Met Pro Cys Ser Leu Gly Thr Phe Val Leu Val Gln 
    770                 775                 780             


<210>  35
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  35
tgtctacacc actgctgcc                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  36
agatcttatt actgagaac                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  37
agaacaccat tatcttcac                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  38
gttctgctgt gcatctgcc                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  39
gacagtcatt gccattgac                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  40
gtttgccatc tgcatcttc                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  41
gtatgtgatc atcgatctc                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  42
caatgaagag cgtgtgttc                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  43
ccaccagcat ggagtcatc                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  44
gccttgtcat ttgacaacc                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  45
cttgtgcgat gctttgaac                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  46
agagttgttg cctgcaatc                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  47
tctatccctt tgtaaagac                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  48
ttatttcagg aaacagtac                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  49
cttgtgtgcc agtggatgc                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  50
aaatccatgc aaacagttc                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  51
caacgtactg gtcaacaac                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  52
aagagtgatg atccaatgc                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  53
tgatccaatg ccctttgac                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  54
tactgccgat aatgaaacc                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  55
agacatggat gggaaagac                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  56
tcatctgcag ccatttacc                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  57
agtagccatt tacctcaac                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  58
ttgatggaat ctctggaac                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  59
tcatgggtat tacatacac                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  60
tgattattgt tgtcatgac                                                    19


<210>  61
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  61
ctactgccgc ttccagaac                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  62
catactggag cctgtaacc                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  63
ctgctgaaga gacaatgac                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  64
tatgctgtag gctgcctgc                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  65
gaagcaagtt cacaattac                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  66
ccaatggtta catggctcc                                                    19


<210>  67
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  67
gaagctggcc taattgaac                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  68
agctgcaact gcactgagc                                                    19


<210>  69
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  69
acacctcctt tctctgaac                                                    19


<210>  70
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  70
atgaccctac aggtttacc                                                    19


<210>  71
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  71
caagaccagc tttgctgcc                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  72
atgacatctt cctggtggc                                                    19


<210>  73
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  73
gctgaaggta gaaccgggc                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  74
ctcaggaagg tctttccac                                                    19


<210>  75
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  75
tttgctgcca tttattacc                                                    19


<210>  76
<211>  12
<212>  RNA
<213>  Artificial

<220>
<223>  Loop sequence

<400>  76
guuugcuaua ac                                                           12


