                               SEQUENCE LISTING	

<110> OHIO STATE UNIVERSITY RESEARCH FOUNDATION
 
<120> SYSTEM FOR MODULATING EXPRESSION OF HYPOTHALMIC BRAIN-DERIVED 
      NEUROTROPHIC FACTOR (BDNF)

<130> 53-50462

<140>
<141>

<150> 61/109,454
<151> 2008-10-29

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> DNA
<213> Mus sp.

<400> 1
aagtgtacaa gtccgcgtcc t                                                 21


<210> 2
<211> 247
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210> 3
<211> 4247
<212> DNA
<213> Homo sapiens

<400> 3
gttccccaac tgctgtttta ttgtgctatt catgcctaga catcacatag ctagaaaggc       60

ccatcagacc cctcaggcca ctgctgttcc tgtcacacat tcctgcaaag gaccatgttg      120

ctaacttgaa aaaaattact attaattaca cttgcagttg ttgcttagta acatttatga      180

ttttgtgttt ctcgtgacag catgagcaga gatcattaaa aattaaactt acaaagctgc      240

taaagtggga agaaggagaa cttgaagcca caatttttgc acttgcttag aagccatcta      300

atctcaggtt tatatgctag atcttggggg aaacactgca tgtctctggt ttatattaaa      360

ccacatacag cacactactg acactgattt gtgtctggtg cagctggagt ttatcaccaa      420

gacataaaaa aaccttgacc ctgcagaatg gcctggaatt acaatcagat gggccacatg      480

gcatcccggt gaaagaaagc cctaaccagt tttctgtctt gtttctgctt tctccctaca      540

gttccaccag gtgagaagag tgatgaccat ccttttcctt actatggtta tttcatactt      600

tggttgcatg aaggctgccc ccatgaaaga agcaaacatc cgaggacaag gtggcttggc      660

ctacccaggt gtgcggaccc atgggactct ggagagcgtg aatgggccca aggcaggttc      720

aagaggcttg acatcattgg ctgacacttt cgaacacgtg atagaagagc tgttggatga      780

ggaccagaaa gttcggccca atgaagaaaa caataaggac gcagacttgt acacgtccag      840

ggtgatgctc agtagtcaag tgcctttgga gcctcctctt ctctttctgc tggaggaata      900

caaaaattac ctagatgctg caaacatgtc catgagggtc cggcgccact ctgaccctgc      960

ccgccgaggg gagctgagcg tgtgtgacag tattagtgag tgggtaacgg cggcagacaa     1020

aaagactgca gtggacatgt cgggcgggac ggtcacagtc cttgaaaagg tccctgtatc     1080

aaaaggccaa ctgaagcaat acttctacga gaccaagtgc aatcccatgg gttacacaaa     1140

agaaggctgc aggggcatag acaaaaggca ttggaactcc cagtgccgaa ctacccagtc     1200

gtacgtgcgg gcccttacca tggatagcaa aaagagaatt ggctggcgat tcataaggat     1260

agacacttct tgtgtatgta cattgaccat taaaagggga agatagtgga tttatgttgt     1320

atagattaga ttatattgag acaaaaatta tctatttgta tatatacata acagggtaaa     1380

ttattcagtt aagaaaaaaa taattttatg aactgcatgt ataaatgaag tttatacagt     1440

acagtggttc tacaatctat ttattggaca tgtccatgac cagaagggaa acagtcattt     1500

gcgcacaact taaaaagtct gcattacatt ccttgataat gttgtggttt gttgccgttg     1560

ccaagaactg aaaacataaa aagttaaaaa aaataataaa ttgcatgctg ctttaattgt     1620

gaattgataa taaactgtcc tctttcagaa aacagaaaaa aaacacacac acacacaaca     1680

aaaatttgaa ccaaaacatt ccgtttacat tttagacagt aagtatcttc gttcttgtta     1740

gtactatatc tgttttactg cttttaactt ctgatagcgt tggaattaaa acaatgtcaa     1800

ggtgctgttg tcattgcttt actggcttag gggatggggg atggggggta tatttttgtt     1860

tgttttgtgt ttttttttcg tttgtttgtt ttgtttttta gttcccacag ggagtagaga     1920

tggggaaaga attcctacaa tatatattct ggctgataaa agatacattt gtatgttgtg     1980

aagatgtttg caatatcgat cagatgacta gaaagtgaat aaaaattaag gcaactgaac     2040

aaaaaaatgc tcacactcca catcccgtga tgcacctccc aggccccgct cattctttgg     2100

gcgttggtca gagtaagctg cttttgacgg aaggacctat gtttgctcag aacacattct     2160

ttccccccct ccccctctgg tctcctcttt gttttgtttt aaggaagaaa aatcagttgc     2220

gcgttctgaa atattttacc actgctgtga acaagtgaac acattgtgtc acatcatgac     2280

actcgtataa gcatggagaa cagtgatttt tttttagaac agaaaacaac aaaaaataac     2340

cccaaaatga agattatttt ttatgaggag tgaacatttg ggtaaatcat ggctaagctt     2400

aaaaaaaact catggtgagg cttaacaatg tcttgtaagc aaaaggtaga gccctgtatc     2460

aacccagaaa cacctagatc agaacaggaa tccacattgc cagtgacatg agactgaaca     2520

gccaaatgga ggctatgtgg agttggcatt gcatttaccg gcagtgcggg aggaatttct     2580

gagtggccat cccaaggtct aggtggaggt ggggcatggt atttgagaca ttccaaaacg     2640

aaggcctctg aaggaccctt cagaggtggc tctggaatga catgtgtcaa gctgcttgga     2700

cctcgtgctt taagtgccta cattatctaa ctgtgctcaa gaggttctcg actggaggac     2760

cacactcaag ccgacttatg cccaccatcc cacctctgga taattttgca taaaattgga     2820

ttagcctgga gcaggttggg agccaaatgt ggcatttgtg atcatgagat tgatgcaatg     2880

agatagaaga tgtttgctac ctgaacactt attgctttga aactagactt gaggaaacca     2940

gggtttatct tttgagaact tttggtaagg gaaaagggaa caggaaaaga aaccccaaac     3000

tcaggccgaa tgatcaaggg gacccatagg aaatcttgtc cagagacaag acttcgggaa     3060

ggtgtctgga cattcagaac accaagactt gaaggtgcct tgctcaatgg aagaggccag     3120

gacagagctg acaaaatttt gctccccagt gaaggccaca gcaaccttct gcccatcctg     3180

tctgttcatg gagagggtcc ctgcctcacc tctgccattt tgggttagga gaagtcaagt     3240

tgggagcctg aaatagtggt tcttggaaaa atggatcccc agtgaaaact agagctctaa     3300

gcccattcag cccatttcac acctgaaaat gttagtgatc accacttgga ccagcatcct     3360

taagtatcag aaagccccaa gcaattgctg catcttagta gggtgaggga taagcaaaag     3420

aggatgttca ccataaccca ggaatgaaga taccatcagc aaagaatttc aatttgttca     3480

gtctttcatt tagagctagt ctttcacagt accatctgaa tacctctttg aaagaaggaa     3540

gactttacgt agtgtagatt tgttttgtgt tgtttgaaaa tattatcttt gtaattattt     3600

ttaatatgta aggaatgctt ggaatatctg ctatatgtca actttatgca gcttcctttt     3660

gagggacaaa tttaaaacaa acaacccccc atcacaaact taaaggattg caagggccag     3720

atctgttaag tggtttcata ggagacacat ccagcaattg tgtggtcagt ggctctttta     3780

cccaataaga tacatcacag tcacatgctt gatggtttat gttgacctaa gatttatttt     3840

gttaaaatct ctctctgttg tgttcgttct tgttctgttt tgttttgttt tttaaagtct     3900

tgctgtggtc tctttgtggc agaagtgttt catgcatggc agcaggcctg ttgctttttt     3960

atggcgattc ccattgaaaa tgtaagtaaa tgtctgtggc cttgttctct ctatggtaaa     4020

gatattattc accatgtaaa acaaaaaaca atatttattg tattttagta tatttatata     4080

attatgttat tgaaaaaaat tggcattaaa acttaaccgc atcagaacct attgtaaata     4140

caagttctat ttaagtgtac taattaacat ataatatatg ttttaaatat agaattttta     4200

atgtttttaa atatattttc aaagtacata aaaaaaaaaa aaaaaaa                   4247


<210> 4
<211> 594
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Woodchuck post-transcriptional 
      regulatory element polynucleotide

<400> 4
ataatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg       60

ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc      120

gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt      180

tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca      240

ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc      300

ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc      360

tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc      420

tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc      480

tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc      540

ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg catc            594


<210> 5
<211> 19
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Woodchuck post-transcriptional 
      regulatory element oligonucleotide

<400> 5
ctatgtggac gctgcttta                                                    19


<210> 6
<211> 19
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: Woodchuck post-transcriptional 
      regulatory element oligonucleotide

<400> 6
tcctggtttg tctctttat                                                    19


<210> 7
<211> 4755
<212> DNA
<213> Homo sapiens

<400> 7
cacacacaca cacacacaca gagagaacat ctctagtaaa aagaaaagtt gagctttctt       60

agctagatgt gtgtattagc cagaaaaagc caaggagtga agggttttag agaactggag      120

gagataaagt ggagtctgca tatgggaggc atttgaaatg gacttaaatg tctttttaat      180

gctgactttt tcagttttct ccttaccaga cacattgttt tcatgacatt agccccaggc      240

atagacacat cattaaaatg aacatgtcaa aaaatgattt ctgtttagaa ataagcaaaa      300

cattttcagt tgtgaccacc caggtgtaga ataaagaaca gtggaattgg gagccctgag      360

ttctaacata aactttcttc atgacataag gcaagtcttc tatggccttt ggtttcctta      420

cctgtaaaac aggatggctc aatgaaatta tctttcttct ttgctataat agagtatctc      480

tgtgggaaga ggaaaaaaaa agtcaattta aaggctcctt atagttcccc aactgctgtt      540

ttattgtgct attcatgcct agacatcaca tagctagaaa ggcccatcag acccctcagg      600

ccactgctgt tcctgtcaca cattcctgca aaggaccatg ttgctaactt gaaaaaaatt      660

actattaatt acacttgcag ttgttgctta gtaacattta tgattttgtg tttctcgtga      720

cagcatgagc agagatcatt aaaaattaaa cttacaaagc tgctaaagtg ggaagaagga      780

gaacttgaag ccacaatttt tgcacttgct tagaagccat ctaatctcag gttatatgct      840

agatcttggg ggcaaacact gcatgtctct ggtttatatt aaaccacata cagcacacta      900

ctgacactga tttgtgtctg gtgcagctgg agtttatcac caagacataa aaaaaccttg      960

accctgcaga atggcctgga attacaatca gatgggccac atggcatccc ggtgaaagaa     1020

agccctaacc agttttctgt cttgtttctg ctttctccct acagttccac caggtgagaa     1080

gagtgatgac catccttttc cttactatgg ttatttcata ctttggttgc atgaaggctg     1140

cccccatgaa agaagcaaac atccgaggac aaggtggctt ggcctaccca ggtgtgcgga     1200

cccatgggac tctggagagc gtgaatgggc ccaaggcagg ttcaagaggc ttgacatcat     1260

tggctgacac tttcgaacac gtgatagaag agctgttgga tgaggaccag aaagttcggc     1320

ccaatgaaga aaacaataag gacgcagact tgtacacgtc cagggtgatg ctcagtagtc     1380

aagtgccttt ggagcctcct cttctctttc tgctggagga atacaaaaat tacctagatg     1440

ctgcaaacat gtccatgagg gtccggcgcc actctgaccc tgcccgccga ggggagctga     1500

gcgtgtgtga cagtattagt gagtgggtaa cggcggcaga caaaaagact gcagtggaca     1560

tgtcgggcgg gacggtcaca gtccttgaaa aggtccctgt atcaaaaggc caactgaagc     1620

aatacttcta cgagaccaag tgcaatccca tgggttacac aaaagaaggc tgcaggggca     1680

tagacaaaag gcattggaac tcccagtgcc gaactaccca gtcgtacgtg cgggccctta     1740

ccatggatag caaaaagaga attggctggc gattcataag gatagacact tcttgtgtat     1800

gtacattgac cattaaaagg ggaagatagt ggatttatgt tgtatagatt agattatatt     1860

gagacaaaaa ttatctattt gtatatatac ataacagggt aaattattca gttaagaaaa     1920

aaataatttt atgaactgca tgtataaatg aagtttatac agtacagtgg ttctacaatc     1980

tatttattgg acatgtccat gaccagaagg gaaacagtca tttgcgcaca acttaaaaag     2040

tctgcattac attccttgat aatgttgtgg tttgttgccg ttgccaagaa ctgaaaacat     2100

aaaaagttaa aaaaaataat aaattgcatg ctgctttaat tgtgaattga taataaactg     2160

tcctctttca gaaaacagaa aaaaacacac acacacacaa caaaaatttg aaccaaaaca     2220

ttccgtttac attttagaca gtaagtatct tcgttcttgt tagtactata tctgttttac     2280

tgcttttaac ttctgatagc gttggaatta aaacaatgtc aaggtgctgt tgtcattgct     2340

ttactggctt aggggatggg ggatgggggg tatatttttg tttgttttgt gttttttttt     2400

cgtttgtttg ttttgttttt tagttcccac agggagtaga gatggggaaa gaattcctac     2460

aatatatatt ctggctgata aaagatacat ttgtatgttg tgaagatgtt tgcaatatcg     2520

atcagatgac tagaaagtga ataaaaatta aggcaactga acaaaaaaat gctcacactc     2580

cacatcccgt gatgcacctc ccaggccccg ctcattcttt gggcgttggt cagagtaagc     2640

tgcttttgac ggaaggacct atgtttgctc agaacacatt ctttcccccc ctccccctct     2700

ggtctcctct ttgttttgtt ttaaggaaga aaaatcagtt gcgcgttctg aaatatttta     2760

ccactgctgt gaacaagtga acacattgtg tcacatcatg acactcgtat aagcatggag     2820

aacagtgatt tttttttaga acagaaaaca acaaaaaata accccaaaat gaagattatt     2880

ttttatgagg agtgaacatt tgggtaaatc atggctaagc ttaaaaaaaa ctcatggtga     2940

ggcttaacaa tgtcttgtaa gcaaaaggta gagccctgta tcaacccaga aacacctaga     3000

tcagaacagg aatccacatt gccagtgaca tgagactgaa cagccaaatg gaggctatgt     3060

ggagttggca ttgcatttac cggcagtgcg ggaggaattt ctgagtggcc atcccaaggt     3120

ctaggtggag gtggggcatg gtatttgaga cattccaaaa cgaaggcctc tgaaggaccc     3180

ttcagaggtg gctctggaat gacatgtgtc aagctgcttg gacctcgtgc tttaagtgcc     3240

tacattatct aactgtgctc aagaggttct cgactggagg accacactca agccgactta     3300

tgcccaccat cccacctctg gataattttg cataaaattg gattagcctg gagcaggttg     3360

ggagccaaat gtggcatttg tgatcatgag attgatgcaa tgagatagaa gatgtttgct     3420

acctgaacac ttattgcttt gaaactagac ttgaggaaac cagggtttat cttttgagaa     3480

cttttggtaa gggaaaaggg aacaggaaaa gaaaccccaa actcaggccg aatgatcaag     3540

gggacccata ggaaatcttg tccagagaca agacttcggg aaggtgtctg gacattcaga     3600

acaccaagac ttgaaggtgc cttgctcaat ggaagaggcc aggacagagc tgacaaaatt     3660

ttgctcccca gtgaaggcca cagcaacctt ctgcccatcc tgtctgttca tggagagggt     3720

ccctgcctca cctctgccat tttgggttag gagaagtcaa gttgggagcc tgaaatagtg     3780

gttcttggaa aaatggatcc ccagtgaaaa ctagagctct aagcccattc agcccatttc     3840

acacctgaaa atgttagtga tcaccacttg gaccagcatc cttaagtatc agaaagcccc     3900

aagcaattgc tgcatcttag tagggtgagg gataagcaaa agaggatgtt caccataacc     3960

caggaatgaa gataccatca gcaaagaatt tcaatttgtt cagtctttca tttagagcta     4020

gtctttcaca gtaccatctg aatacctctt tgaaagaagg aagactttac gtagtgtaga     4080

tttgttttgt gttgtttgaa aatattatct ttgtaattat ttttaatatg taaggaatgc     4140

ttggaatatc tgctatatgt caactttatg cagcttcctt ttgagggaca aatttaaaac     4200

aaacaacccc ccatcacaaa cttaaaggat tgcaagggcc agatctgtta agtggtttca     4260

taggagacac atccagcaat tgtgtggtca gtggctcttt tacccaataa gatacatcac     4320

agtcacatgc ttgatggttt atgttgacct aagatttatt ttgttaaaat ctctctctgt     4380

tgtgttcgtt cttgttctgt tttgttttgt tttttaaagt cttgctgtgg tctctttgtg     4440

gcagaagtgt ttcatgcatg gcagcaggcc tgttgctttt ttatggcgat tcccattgaa     4500

aatgtaagta aatgtctgtg gccttgttct ctctatggta aagatattat tcaccatgta     4560

aaacaaaaaa caatatttat tgtattttag tatatttata taattatgtt attgaaaaaa     4620

attggcatta aaacttaacc gcatcagaac ctattgtaaa tacaagttct atttaagtgt     4680

actaattaac atataatata tgttttaaat atagaatttt taatgttttt aaatatattt     4740

tcaaagtaca taaaa                                                      4755


