                         SEQUENCE LISTING

<110>  SYGNIS Bioscience GmbH & Co KG
 
<120>  USE OF G-CSF FOR THE EXTENSION OF THE THERAPEUTIC TIME-WINDOW OF 
       THROMBOLYTIC STROKE THERAPY

<130>  338555PCT

<150>  US 61/153,079
<151>  2009-02-17

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  612
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(612)

<400>  1
atg gct gga cct gcc acc cag agc ccc atg aag ctg atg gcc ctg cag       48
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln         
1               5                   10                  15              

ctg ctg ctg tgg cac agt gca ctc tgg aca gtg cag gaa gcc acc ccc       96
Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro         
            20                  25                  30                  

ctg ggc cct gcc agc tcc ctg ccc cag agc ttc ctg ctc aag tgc tta      144
Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu         
        35                  40                  45                      

gag caa gtg agg aag atc cag ggc gat ggc gca gcg ctc cag gag aag      192
Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys         
    50                  55                  60                          

ctg tgt gcc acc tac aag ctg tgc cac ccc gag gag ctg gtg ctg ctc      240
Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu         
65                  70                  75                  80          

gga cac tct ctg ggc atc ccc tgg gct ccc ctg agc agc tgc ccc agc      288
Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser         
                85                  90                  95              

cag gcc ctg cag ctg gca ggc tgc ttg agc caa ctc cat agc ggc ctt      336
Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu         
            100                 105                 110                 

ttc ctc tac cag ggg ctc ctg cag gcc ctg gaa ggg atc tcc ccc gag      384
Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu         
        115                 120                 125                     

ttg ggt ccc acc ttg gac aca ctg cag ctg gac gtc gcc gac ttt gcc      432
Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala         
    130                 135                 140                         

acc acc atc tgg cag cag atg gaa gaa ctg gga atg gcc cct gcc ctg      480
Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu         
145                 150                 155                 160         

cag ccc acc cag ggt gcc atg ccg gcc ttc gcc tct gct ttc cag cgc      528
Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg         
                165                 170                 175             

cgg gca gga ggg gtc ctg gtt gcc tcc cat ctg cag agc ttc ctg gag      576
Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu         
            180                 185                 190                 

gtg tcg tac cgc gtt cta cgc cac ctt gcc cag ccc                      612
Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro                         
        195                 200                                         


<210>  2
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  3
<211>  522
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(522)

<400>  3
acc ccc ctg ggc cct gcc agc tcc ctg ccc cag agc ttc ctg ctc aag       48
Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys         
1               5                   10                  15              

tgc tta gag caa gtg agg aag atc cag ggc gat ggc gca gcg ctc cag       96
Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln         
            20                  25                  30                  

gag aag ctg tgt gcc acc tac aag ctg tgc cac ccc gag gag ctg gtg      144
Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val         
        35                  40                  45                      

ctg ctc gga cac tct ctg ggc atc ccc tgg gct ccc ctg agc agc tgc      192
Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys         
    50                  55                  60                          

ccc agc cag gcc ctg cag ctg gca ggc tgc ttg agc caa ctc cat agc      240
Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser         
65                  70                  75                  80          

ggc ctt ttc ctc tac cag ggg ctc ctg cag gcc ctg gaa ggg atc tcc      288
Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser         
                85                  90                  95              

ccc gag ttg ggt ccc acc ttg gac aca ctg cag ctg gac gtc gcc gac      336
Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp         
            100                 105                 110                 

ttt gcc acc acc atc tgg cag cag atg gaa gaa ctg gga atg gcc cct      384
Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro         
        115                 120                 125                     

gcc ctg cag ccc acc cag ggt gcc atg ccg gcc ttc gcc tct gct ttc      432
Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe         
    130                 135                 140                         

cag cgc cgg gca gga ggg gtc ctg gtt gcc tcc cat ctg cag agc ttc      480
Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe         
145                 150                 155                 160         

ctg gag gtg tcg tac cgc gtt cta cgc cac ctt gcc cag ccc              522
Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro                 
                165                 170                                 


<210>  4
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 
            100                 105                 110         


Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 
        115                 120                 125             


Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 


<210>  5
<211>  621
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(621)

<400>  5
atg gct gga cct gcc acc cag agc ccc atg aag ctg atg gcc ctg cag       48
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln         
1               5                   10                  15              

ctg ctg ctg tgg cac agt gca ctc tgg aca gtg cag gaa gcc acc ccc       96
Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro         
            20                  25                  30                  

ctg ggc cct gcc agc tcc ctg ccc cag agc ttc ctg ctc aag tgc tta      144
Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu         
        35                  40                  45                      

gag caa gtg agg aag atc cag ggc gat ggc gca gcg ctc cag gag aag      192
Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys         
    50                  55                  60                          

ctg gtg agt gag tgt gcc acc tac aag ctg tgc cac ccc gag gag ctg      240
Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu         
65                  70                  75                  80          

gtg ctg ctc gga cac tct ctg ggc atc ccc tgg gct ccc ctg agc agc      288
Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser         
                85                  90                  95              

tgc ccc agc cag gcc ctg cag ctg gca ggc tgc ttg agc caa ctc cat      336
Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His         
            100                 105                 110                 

agc ggc ctt ttc ctc tac cag ggg ctc ctg cag gcc ctg gaa ggg atc      384
Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile         
        115                 120                 125                     

tcc ccc gag ttg ggt ccc acc ttg gac aca ctg cag ctg gac gtc gcc      432
Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala         
    130                 135                 140                         

gac ttt gcc acc acc atc tgg cag cag atg gaa gaa ctg gga atg gcc      480
Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala         
145                 150                 155                 160         

cct gcc ctg cag ccc acc cag ggt gcc atg ccg gcc ttc gcc tct gct      528
Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala         
                165                 170                 175             

ttc cag cgc cgg gca gga ggg gtc ctg gtt gcc tcc cat ctg cag agc      576
Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser         
            180                 185                 190                 

ttc ctg gag gtg tcg tac cgc gtt cta cgc cac ctt gcc cag ccc          621
Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro             
        195                 200                 205                     


<210>  6
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  7
<211>  531
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(531)

<400>  7
acc ccc ctg ggc cct gcc agc tcc ctg ccc cag agc ttc ctg ctc aag       48
Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys         
1               5                   10                  15              

tgc tta gag caa gtg agg aag atc cag ggc gat ggc gca gcg ctc cag       96
Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln         
            20                  25                  30                  

gag aag ctg gtg agt gag tgt gcc acc tac aag ctg tgc cac ccc gag      144
Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu         
        35                  40                  45                      

gag ctg gtg ctg ctc gga cac tct ctg ggc atc ccc tgg gct ccc ctg      192
Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu         
    50                  55                  60                          

agc agc tgc ccc agc cag gcc ctg cag ctg gca ggc tgc ttg agc caa      240
Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln         
65                  70                  75                  80          

ctc cat agc ggc ctt ttc ctc tac cag ggg ctc ctg cag gcc ctg gaa      288
Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu         
                85                  90                  95              

ggg atc tcc ccc gag ttg ggt ccc acc ttg gac aca ctg cag ctg gac      336
Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp         
            100                 105                 110                 

gtc gcc gac ttt gcc acc acc atc tgg cag cag atg gaa gaa ctg gga      384
Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly         
        115                 120                 125                     

atg gcc cct gcc ctg cag ccc acc cag ggt gcc atg ccg gcc ttc gcc      432
Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala         
    130                 135                 140                         

tct gct ttc cag cgc cgg gca gga ggg gtc ctg gtt gcc tcc cat ctg      480
Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu         
145                 150                 155                 160         

cag agc ttc ctg gag gtg tcg tac cgc gtt cta cgc cac ctt gcc cag      528
Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln         
                165                 170                 175             

ccc                                                                  531
Pro                                                                     
                                                                        


<210>  8
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 
        35                  40                  45              


Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu 
    50                  55                  60                  


Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln 
65                  70                  75                  80  


Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu 
                85                  90                  95      


Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 
            100                 105                 110         


Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 
        115                 120                 125             


Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 
    130                 135                 140                 


Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 
145                 150                 155                 160 


Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln 
                165                 170                 175     


Pro 
    


<210>  9
<211>  525
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(525)

<400>  9
atg acc ccc ctg ggc cct gcc agc tcc ctg ccc cag agc ttc ctg ctc       48
Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu         
1               5                   10                  15              

aag tgc tta gag caa gtg agg aag atc cag ggc gat ggc gca gcg ctc       96
Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu         
            20                  25                  30                  

cag gag aag ctg tgt gcc acc tac aag ctg tgc cac ccc gag gag ctg      144
Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu         
        35                  40                  45                      

gtg ctg ctc gga cac tct ctg ggc atc ccc tgg gct ccc ctg agc agc      192
Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser         
    50                  55                  60                          

tgc ccc agc cag gcc ctg cag ctg gca ggc tgc ttg agc caa ctc cat      240
Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His         
65                  70                  75                  80          

agc ggc ctt ttc ctc tac cag ggg ctc ctg cag gcc ctg gaa ggg atc      288
Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile         
                85                  90                  95              

tcc ccc gag ttg ggt ccc acc ttg gac aca ctg cag ctg gac gtc gcc      336
Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala         
            100                 105                 110                 

gac ttt gcc acc acc atc tgg cag cag atg gaa gaa ctg gga atg gcc      384
Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala         
        115                 120                 125                     

cct gcc ctg cag ccc acc cag ggt gcc atg ccg gcc ttc gcc tct gct      432
Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala         
    130                 135                 140                         

ttc cag cgc cgg gca gga ggg gtc ctg gtt gcc tcc cat ctg cag agc      480
Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser         
145                 150                 155                 160         

ttc ctg gag gtg tcg tac cgc gtt cta cgc cac ctt gcc cag ccc          525
Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro             
                165                 170                 175             


<210>  10
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  11
<211>  208
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Gln Leu Ser Ala Gln Arg Arg Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp Gln Ser Ala Leu Trp Ser Gly Arg Glu Ala Val Pro 
            20                  25                  30          


Leu Val Thr Val Ser Ala Leu Pro Pro Ser Leu Pro Leu Pro Arg Ser 
        35                  40                  45              


Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Ala Ser Gly 
    50                  55                  60                  


Ser Val Leu Leu Glu Gln Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 
65                  70                  75                  80  


Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Lys Ala Ser 
                85                  90                  95      


Leu Ser Gly Cys Ser Ser Gln Ala Leu Gln Gln Thr Gln Cys Leu Ser 
            100                 105                 110         


Gln Leu His Ser Gly Leu Cys Leu Tyr Gln Gly Leu Leu Gln Ala Leu 
        115                 120                 125             


Ser Gly Ile Ser Pro Ala Leu Ala Pro Thr Leu Asp Leu Leu Gln Leu 
    130                 135                 140                 


Asp Val Ala Asn Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Asn Leu 
145                 150                 155                 160 


Gly Val Ala Pro Thr Val Gln Pro Thr Gln Ser Ala Met Pro Ala Phe 
                165                 170                 175     


Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Ala Ile Ser Tyr 
            180                 185                 190         


Leu Gln Gly Phe Leu Glu Thr Ala Arg Leu Ala Leu His His Leu Ala 
        195                 200                 205             


<210>  12
<211>  214
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Lys Leu Met Ala Leu Gln Leu Leu Leu Trp His Ser Ala Leu Trp 
1               5                   10                  15      


Ser Gly Gln Glu Ala Ile Pro Leu Leu Thr Val Ser Ser Leu Pro Pro 
            20                  25                  30          


Ser Leu Pro Leu Pro Arg Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 
        35                  40                  45              


Arg Lys Ile Gln Ala Arg Asn Thr Glu Leu Leu Glu Gln Leu Cys Ala 
    50                  55                  60                  


Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Phe Gly His Ser 
65                  70                  75                  80  


Leu Gly Ile Pro Lys Ala Ser Leu Ser Ser Cys Ser Ser Gln Ala Leu 
                85                  90                  95      


Gln Gln Thr Lys Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr 
            100                 105                 110         


Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser Ser Glu Leu Ala Pro 
        115                 120                 125             


Thr Leu Asp Met Leu His Leu Asp Val Asp Asn Phe Ala Thr Thr Ile 
    130                 135                 140                 


Trp Gln Gln Met Glu Ser Leu Gly Val Ala Pro Thr Val Gln Pro Thr 
145                 150                 155                 160 


Gln Ser Thr Met Pro Ile Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly 
                165                 170                 175     


Gly Val Leu Val Thr Ser Tyr Leu Gln Ser Phe Leu Glu Thr Ala His 
            180                 185                 190         


His Ala Leu His His Leu Pro Arg Pro Ala Gln Lys His Phe Pro Glu 
        195                 200                 205             


Ser Leu Phe Ile Ser Ile 
    210                 


<210>  13
<211>  194
<212>  PRT
<213>  Felis catus

<400>  13

Lys Leu Met Ala Leu Gln Leu Leu Leu Trp His Ser Ala Leu Trp Met 
1               5                   10                  15      


Val Gln Glu Ala Thr Pro Leu Gly Pro Thr Ser Ser Leu Pro Gln Ser 
            20                  25                  30          


Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Val Gln Ala Asp Gly 
        35                  40                  45              


Thr Ala Leu Gln Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro 
    50                  55                  60                  


Glu Glu Leu Val Leu Leu Gly His Ala Leu Gly Ile Pro Gln Ala Pro 
65                  70                  75                  80  


Leu Ser Ser Cys Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu Arg 
                85                  90                  95      


Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 
            100                 105                 110         


Ala Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Met Leu Gln Leu 
        115                 120                 125             


Asp Ile Thr Asp Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Val 
    130                 135                 140                 


Gly Met Ala Pro Ala Val Pro Pro Thr Gln Gly Thr Met Pro Thr Phe 
145                 150                 155                 160 


Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Thr Leu Val Ala Ser Asn 
                165                 170                 175     


Leu Gln Ser Phe Leu Glu Val Ala Tyr Arg Ala Leu Arg His Phe Thr 
            180                 185                 190         


Lys Pro 
        


<210>  14
<211>  195
<212>  PRT
<213>  Bos taurus

<400>  14

Met Lys Leu Met Val Leu Gln Leu Leu Leu Trp His Ser Ala Leu Trp 
1               5                   10                  15      


Thr Val His Glu Ala Thr Pro Leu Gly Pro Ala Arg Ser Leu Pro Gln 
            20                  25                  30          


Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp 
        35                  40                  45              


Gly Ala Glu Leu Gln Glu Arg Leu Cys Ala Ala His Lys Leu Cys His 
    50                  55                  60                  


Pro Glu Glu Leu Met Leu Leu Arg His Ser Leu Gly Ile Pro Gln Ala 
65                  70                  75                  80  


Pro Leu Ser Ser Cys Ser Ser Gln Ser Leu Gln Leu Thr Ser Cys Leu 
                85                  90                  95      


Asn Gln Leu His Gly Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 
            100                 105                 110         


Leu Ala Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln 
        115                 120                 125             


Leu Asp Val Thr Asp Phe Ala Thr Asn Ile Trp Leu Gln Met Glu Asp 
    130                 135                 140                 


Leu Gly Ala Ala Pro Ala Val Gln Pro Thr Gln Gly Ala Met Pro Thr 
145                 150                 155                 160 


Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 
                165                 170                 175     


Gln Leu His Arg Phe Leu Glu Leu Ala Tyr Arg Gly Leu Arg Tyr Leu 
            180                 185                 190         


Ala Glu Pro 
        195 


<210>  15
<211>  195
<212>  PRT
<213>  Sus scrofa

<400>  15

Met Lys Leu Met Ala Leu Gln Leu Leu Leu Trp His Ile Ala Leu Trp 
1               5                   10                  15      


Met Val Pro Glu Ala Ala Pro Leu Ser Pro Ala Ser Ser Leu Pro Gln 
            20                  25                  30          


Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp 
        35                  40                  45              


Gly Ala Glu Leu Gln Glu Arg Leu Cys Ala Thr His Lys Leu Cys His 
    50                  55                  60                  


Pro Gln Glu Leu Val Leu Leu Gly His Ser Leu Gly Leu Pro Gln Ala 
65                  70                  75                  80  


Ser Leu Ser Ser Cys Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu 
                85                  90                  95      


Asn Gln Leu His Gly Gly Leu Val Leu Tyr Gln Gly Leu Leu Gln Ala 
            100                 105                 110         


Leu Ala Gly Ile Ser Pro Glu Leu Ala Pro Ala Leu Asp Ile Leu Gln 
        115                 120                 125             


Leu Asp Val Thr Asp Leu Ala Thr Asn Ile Trp Leu Gln Met Glu Asp 
    130                 135                 140                 


Leu Arg Met Ala Pro Ala Ser Leu Pro Thr Gln Gly Thr Val Pro Thr 
145                 150                 155                 160 


Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Val Ser 
                165                 170                 175     


Gln Leu Gln Ser Phe Leu Glu Leu Ala Tyr Arg Val Leu Arg Tyr Leu 
            180                 185                 190         


Ala Glu Pro 
        195 


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide for GCSF

<400>  16

Leu Gly His Ser Leu Gly Ile 
1               5           


<210>  17
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>  Artifical variant of human G-CSF

<400>  17

Ala Pro Thr Thr Arg Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 
            100                 105                 110         


Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 
        115                 120                 125             


Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 


