                         SEQUENCE LISTING

<110> 	Institut Pasteur
	HKU-Pasteur Research Centre
	WANG Peigang
	ALTMEYER Ralf
	NAL-ROGIER Batrice
	KUDELKO Mateusz
	DESPRES Philippe
 
<120>  Dengue Virus-Like Particle And Uses Thereof

<130>  F226/Cas177PCT

<160>  8     

<170>  PatentIn version 3.4

<210>  1
<211>  2055
<212>  DNA
<213>  Artificial

<220>
<223>  Codon optimized Dengue Virus serotype 1 construct

<400>  1
ggatccgcca ccatgaagtg cctgctgtac ctggccttcc tgttcatcgg cgtgaactgc     60

ttccacctga ccaccagagg cggcgagccc cacatgatcg tgtccaagca ggagagaggc    120

aagagcctgc tgttcaagac cagcgccgga gtgaacatgt gtaccctgat cgccatggat    180

ctgggcgagc tgtgtgagga caccatgacc tacaagtgcc ccagaatcac cgaggccgag    240

cccgacgacg tggactgctg gtgtaacgcc accgatacct gggtgaccta cggcacctgt    300

agccagaccg gcgagcacag gagagacaag agaagcgtgg ccctggcccc ccatgtgggc    360

ctgggcctgg agaccagaac cgagacctgg atgagcagcg agggcgcctg gaagcagatc    420

cagaaggtgg agacctgggc cctgagacac cccggcttca ccgtgatcgc cctgttcctg    480

gcccacgcca tcggcaccag catcacccag aagggcatca tcttcatcct gctgatgctg    540

gtgaccccta gcatggccat gagatgtgtg ggcatcggca acagggactt cgtggagggc    600

ctgagcggcg ccacctgggt ggacgtggtg ctggagcacg gcagctgtgt gaccaccatg    660

gccaagaaca agcccaccct ggacatcgag ctgctgaaaa ccgaggtgac caaccctgcc    720

gtgctgagga agctgtgtat cgaggccaag atcagcaaca ccaccaccga cagcagatgc    780

cccacccagg gcgaggccac cctggtggag gagcaggacg ccaacttcgt gtgtcggagg    840

accgtggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cagcctgctg    900

acctgtgcca agttcaagtg tgtgaccaag ctggagggca agatcgtgca gtacgagaac    960

ctgaagtaca gcgtgatcgt gaccgtgcac accggcgacc agcaccaagt gggcaacgag   1020

accaccgagc acggcaccat cgccaccatc accccccagg cccctaccag cgagatccag   1080

ctgaccgatt acggcaccct gaccctggat tgtagcccta gaaccggcct ggacttcaac   1140

gagatggtgc tgctgaccat gaaggagaag agctggctgg tgcacaagca gtggttcctg   1200

gacctgcccc tgccctggac cagcggcgcc agcacctccc aggagacctg gaacagacag   1260

gacctgctgg tgacattcaa gaccgcccac gccaagaagc aggaggtggt ggtgctgggc   1320

agccaagagg gcgccatgca caccgccctg acaggcgcca ccgagatcca gaccagcggc   1380

accaccacaa tcttcgccgg ccacctgaag tgtcggctga agatggacaa gctgaccctg   1440

aagggcatga gctacgtgat gtgtaccggc agcttcaagc tggagaagga ggtggccgag   1500

acccagcacg gcacagtgct ggtgcaggtg aagtacgagg gcaccgacgc cccctgtaag   1560

atccctttca gcacccagga tgagaagggc gtgacacaga acggcagact gatcaccgcc   1620

aaccccatcg tgaccgacaa ggagaagccc gtgaacatcg agaccgagcc ccccttcggc   1680

gagagctaca tcattgtggg agccggcgag aaggccctga agctgtcctg gttcaagaag   1740

ggcagcagca tcggcaagat gttcgaggcc accgccagag gcgccagaag aatggccatc   1800

ctgggcgata ccgcctggga cttcggctcc atcggcggcg tgttcacctc tgtgggcaag   1860

ctggtgcatc aggtgttcgg caccgcctac ggcgtgctgt tcagcggagt gagctggacc   1920

atgaagatcg gcatcggcat cctgctgaca tggctgggcc tgaattctag aagcgccagc   1980

ctgagcatga cctgtatcgc tgtgggcatg gtgaccctgt acctgggcgt gatggtgcag   2040

gcctgatgac tcgag                                                    2055


<210>  2
<211>  2055
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 2 construct

<400>  2
ggatccgcca ccatgaaatg tctgctgtac ctggccttcc tgttcatcgg cgtgaattgt     60

ttccacctga ccaccaggaa cggcgagccc cacatgatcg tgagcagaca ggagaagggc    120

aagagcctgc tgttcaagac cgaggacggc gtgaacatgt gtaccctgat ggccatggac    180

ctgggcgagc tgtgcgagga caccatcacc tacaagtgtc ccttcctgag gcagaacgag    240

cccgaggaca tcgactgttg gtgtaacagc acaagcacct gggtgaccta cggcacctgc    300

accaccaccg gcgagcacag aagggagaag aggagcgtgg ccctggtgcc ccacgtgggc    360

atgggattgg aaaccagaac cgagacctgg atgagcagcg agggcgcttg gaagcatgcc    420

cagagaatcg agacctggat tctgagacac cccggcttca ccatcatggc cgccatcctg    480

gcctacacca tcggcaccac ccacttccag agagccctga tcttcatcct gctgaccgcc    540

gtggccccca gcatgaccat gagatgcatc ggcatcagca acagagactt cgtggagggc    600

gtgagcggcg gcagctgggt ggacatcgtg ctggagcacg gcagctgtgt gaccaccatg    660

gccaagaaca agcccacact ggacttcgag ctgatcaaga ccgaggccaa gcagcccgcc    720

accctgagaa agtactgtat cgaggccaag ctgaccaaca ccaccaccga cagcagatgc    780

cccacccagg gcgagcccag cctcaatgag gagcaggaca agagattcgt gtgtaagcac    840

agcatggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cggcatcgtg    900

acctgtgcca tgttcacatg caagaagaac atgaagggca aggtggtgca gcctgagaac    960

ctggagtaca ccatcgtgat cacccctcac tctggcgagg agcatgccgt gggcaacgac   1020

accggcaagc acggcaagga gatcaagatc accccccaga gcagcatcac agaggccgag   1080

ctgaccggct acggcacagt gaccatggag tgtagcccta gaaccggcct ggatttcaac   1140

gagatggtgc tgctgcaaat ggagaacaag gcctggctgg tgcacagaca atggttcctg   1200

gatctgcctc tgccctggct gcctggcgcc gacacccagg gaagcaactg gattcagaag   1260

gagaccctgg tgaccttcaa gaacccccac gccaagaagc aggacgtggt ggtgctgggc   1320

agccaggagg gcgccatgca caccgccctg acaggcgcca ccgagatcca gatgagcagc   1380

ggcaacctgc tgttcaccgg ccatttgaaa tgtagactga gaatggataa gctgcagctg   1440

aagggcatgt cttacagcat gtgtacaggc aagttcaagg tggtgaagga gatcgccgag   1500

acccagcacg gcaccatcgt gatcagagtg cagtacgagg gcgatggcag cccctgtaag   1560

atccccttcg agatcatgga tttggagaag agacacgtgc tgggcagact gatcaccgtg   1620

aaccccatcg tgaccgagaa ggatagcccc gtgaacatcg aggccgagcc ccctttcggc   1680

gacagctaca tcatcatcgg cgtggagccc ggccagctga agctgaactg gttcaagaag   1740

ggcagcagca tcggccagat gatcgagacc accatgagag gagccaagcg gatggccatc   1800

ctgggcgaca ccgcctggga cttcggctct ctgggcggcg tgttcacctc catcggcaag   1860

gccctgcacc aggtgttcgg cgccatctac ggcgccgcct tctccggcgt gtcctggacc   1920

atgaagatcc tgatcggcgt gatcatcacc tggatcggca tgaattccag aagcaccagc   1980

ctgagcgtgt ccctggtgct ggtcggagtg gtgaccctgt acctgggcgt gatggtgcag   2040

gcctgatgac tcgag                                                    2055


<210>  3
<211>  2049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 3 construct

<400>  3
ggatccgcca ccatgaagtg tctgctgtac ctggccttcc tgttcatcgg cgtgaactgc     60

ttccatctga ccagcagaga cggcgagccc agaatgatcg tgggcaagaa cgagagaggc    120

aagagcctgc tgttcaagac cgccagcggc atcaacatgt gtaccctgat cgccatggac    180

ctgggcgaga tgtgtgacga caccgtgacc tacaagtgtc cccacatcac cgaggtggag    240

cccgaggaca tcgactgttg gtgtaacctg acaagcacct gggtgaccta cggcacatgc    300

aaccaggccg gcgagcacag aagggacaag agaagcgtgg ccctggcccc ccacgtgggc    360

atgggcctgg ataccagaac ccagacctgg atgagcgccg agggcgcttg gagacaggtg    420

gagaaggtgg agacctgggc cctgagacac cccggcttca ccatcctggc cctgttcctg    480

gcccattaca tcggcaccag cctgacccag aaggtggtga tcttcatcct gctgatgctg    540

gtgaccccca gcatgaccat gcggtgtgtg ggcgtgggca acagagattt cgtggagggc    600

ctgagcggcg ccacctgggt ggacgtggtg ctggagcacg gcggctgtgt gaccaccatg    660

gccaagaata agcccaccct ggatatcgag ctgcagaaga ccgaggccac ccagctggcc    720

accctgagaa agctgtgcat cgagggcaag atcaccaaca tcaccaccga cagccggtgt    780

cctacccaag gcgaggccat cctgcccgag gagcaggacc agaactacgt gtgcaagcac    840

acatatgtgg atagaggctg gggcaacggc tgtggcctgt tcggcaaggg cagcctggtg    900

acctgtgcca agttccaatg tctggagtct atcgagggca aggtggtgca gcacgagaac    960

ctgaagtaca ccgtgattat caccgtgcac accggcgacc agcaccaggt gggcaacgag   1020

acccagggcg tgaccgccga gatcacctcc caggccagca cagccgaggc catcctgccc   1080

gagtacggca ccctgggcct ggagtgttcc cccaggaccg gcctggactt caatgagatg   1140

atcctgctga ccatgaagaa caaggcttgg atggtgcaca gacagtggtt cttcgacctg   1200

cccctgccct ggaccagcgg cgccaccacc aagaccccca catggaacag aaaggagctg   1260

ctggtgacct tcaagaacgc ccacgccaag aagcaggagg tggtggtgct gggcagccaa   1320

gagggcgcca tgcacaccgc cctgaccggc gccaccgaga tccagaccag cggcggcaca   1380

tctatcttcg ccggccactt gaaatgtaga ctgaagatgg acaagctgaa gctgaagggc   1440

atgagctacg ccatgtgcct gaacaccttc gtgttgaaaa aggaggtgag cgagacccag   1500

cacggcacca tcctgatcaa ggtggagtac aagggcgagg acgccccctg taagatccct   1560

ttcagcaccg aggatggcca gggcaaggcc cacaacggca gactgatcac cgccaacccc   1620

gtggtgacca agaaggagga gcccgtgaac atcgaggccg agcccccctt cggcgagagc   1680

aacatcgtga tcggcatcgg cgacaaggcc ctgaagatca actggtacag aaagggcagc   1740

agcatcggca agatgttcga ggccaccgcc aggggcgcca gaaggatggc tatcctgggc   1800

gacaccgcct gggacttcgg cagcgtgggc ggcgtgctga acagcctggg caagatggtg   1860

caccagatct tcggcagcgc ctacacagcc ctgttctccg gagtgagctg gatcatgaag   1920

atcggaatcg gcgtgctgct gacctggatc ggactgaatt ccaaaaacac cagcatgagc   1980

ttcagctgta tcgccatcgg catcatcacc ctgtacctgg gagtggtggt gcaggcctga   2040

tgactcgag                                                           2049


<210>  4
<211>  2055
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 4 construct

<400>  4
ggatccgcca ccatgaagtg tctgctgtac ctggccttcc tgttcatcgg cgtgaactgt     60

ttcagcctga gcaccagaga cggcgagccc ctgatgatcg tggccaagca cgagagaggc    120

agacccctgc tgttcaagac caccgagggc atcaacaagt gtaccctgat tgccatggat    180

ctgggcgaga tgtgtgagga caccgtgacc tacaagtgtc ccctgctggt gaacacagag    240

cccgaggaca tcgactgctg gtgtaacctg accagcacat gggtgatgta cggcacctgt    300

acccagagcg gcgagaggag acgggagaag agatccgtgg ccctgacccc tcacagcggc    360

atgggcttgg aaacaagggc tgagacctgg atgagcagcg agggcgcctg gaagcacgcc    420

cagagagtgg agagctggat tctgagaaac cctggcttcg ccctgctggc cggcttcatg    480

gcctacatga tcggccagac cggcatccag aggaccgtgt tcttcgtgct gatgatgctg    540

gtcgccccca gctacggcat gagatgtgtg ggcgtgggca accgggactt cgtggagggc    600

gtgagcggcg gcgcctgggt ggacctggtg ctggagcacg gcggctgtgt gaccaccatg    660

gcccagggca agcctacact ggacttcgag ctgaccaaga ccaccgccaa ggaggtggcc    720

ctgctgagaa cctactgtat cgaggccagc atcagcaaca tcaccaccgc caccaggtgt    780

cccacccaag gcgagcctta tttgaaagaa gagcaggacc agcagtacat ttgtagaaga    840

gacgtggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cggcgtggtg    900

acctgcgcca agttcagctg tagcggcaag atcaccggca acctggtgca gatcgagaac    960

ctggagtaca ccgtggtggt gaccgtgcac aacggcgata cccacgccgt gggcaacgat   1020

accagcaacc acggcgtgac cgccatgatc acccccagaa gccccagcgt ggaggtgaag   1080

ctgcccgact acggcgagct gaccctggac tgcgagccca gaagcggcat cgacttcaac   1140

gagatgattt tgatgaaaat gaaaaagaag acctggctgg tgcacaagca atggttcctg   1200

gacctgcccc tgccctggac cgccggagcc gacaccagcg aggtgcactg gaattacaag   1260

gagagaatgg tgaccttcaa ggtgccccac gccaagagac aggacgtgac cgtgctgggc   1320

agccaggagg gcgccatgca cagcgccctg gccggcgcca ccgaggtgga tagcggcgac   1380

ggcaaccata tgttcgccgg ccacttgaaa tgcaaagtga ggatggagaa gctgagaatc   1440

aagggcatgt cctacacaat gtgtagcggc aagttcagca tcgataagga gatggccgag   1500

acccagcatg gcaccaccgt ggtgaaggtg aagtacgagg gcgccggcgc tccctgcaag   1560

gtgcccattg agatcagaga cgtgaacaag gagaaggtgg tgggcagaat catcagctct   1620

acccccctgg ccgagaacac caatagcgtg accaacatcg agctggagcc tcccttcgga   1680

gacagctaca tcgtgatcgg cgtgggcaac agcgccctga ccctgcactg gttcagaaag   1740

ggcagctcta tcggcaagat gttcgagtcc acatatagag gcgccaagag aatggccatc   1800

ctgggcgaga ccgcctggga tttcggcagc gtgggcggcc tgttcaccag cctgggcaag   1860

gccgtgcacc aggtgttcgg ctccgtgtac accaccatgt tcggcggcgt gagctggatg   1920

atccggattc tgatcggctt cctggtgctg tggatcggca cgaattccag aaacaccagc   1980

atggccatga cctgtatcgc cgtgggcgga atcaccctgt tcctgggatt caccgtgcag   2040

gcctgatgac tcgag                                                    2055


<210>  5
<211>  1983
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 1 prME

<400>  5
ttccacctga ccaccagagg cggcgagccc cacatgatcg tgtccaagca ggagagaggc     60

aagagcctgc tgttcaagac cagcgccgga gtgaacatgt gtaccctgat cgccatggat    120

ctgggcgagc tgtgtgagga caccatgacc tacaagtgcc ccagaatcac cgaggccgag    180

cccgacgacg tggactgctg gtgtaacgcc accgatacct gggtgaccta cggcacctgt    240

agccagaccg gcgagcacag gagagacaag agaagcgtgg ccctggcccc ccatgtgggc    300

ctgggcctgg agaccagaac cgagacctgg atgagcagcg agggcgcctg gaagcagatc    360

cagaaggtgg agacctgggc cctgagacac cccggcttca ccgtgatcgc cctgttcctg    420

gcccacgcca tcggcaccag catcacccag aagggcatca tcttcatcct gctgatgctg    480

gtgaccccta gcatggccat gagatgtgtg ggcatcggca acagggactt cgtggagggc    540

ctgagcggcg ccacctgggt ggacgtggtg ctggagcacg gcagctgtgt gaccaccatg    600

gccaagaaca agcccaccct ggacatcgag ctgctgaaaa ccgaggtgac caaccctgcc    660

gtgctgagga agctgtgtat cgaggccaag atcagcaaca ccaccaccga cagcagatgc    720

cccacccagg gcgaggccac cctggtggag gagcaggacg ccaacttcgt gtgtcggagg    780

accgtggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cagcctgctg    840

acctgtgcca agttcaagtg tgtgaccaag ctggagggca agatcgtgca gtacgagaac    900

ctgaagtaca gcgtgatcgt gaccgtgcac accggcgacc agcaccaagt gggcaacgag    960

accaccgagc acggcaccat cgccaccatc accccccagg cccctaccag cgagatccag   1020

ctgaccgatt acggcaccct gaccctggat tgtagcccta gaaccggcct ggacttcaac   1080

gagatggtgc tgctgaccat gaaggagaag agctggctgg tgcacaagca gtggttcctg   1140

gacctgcccc tgccctggac cagcggcgcc agcacctccc aggagacctg gaacagacag   1200

gacctgctgg tgacattcaa gaccgcccac gccaagaagc aggaggtggt ggtgctgggc   1260

agccaagagg gcgccatgca caccgccctg acaggcgcca ccgagatcca gaccagcggc   1320

accaccacaa tcttcgccgg ccacctgaag tgtcggctga agatggacaa gctgaccctg   1380

aagggcatga gctacgtgat gtgtaccggc agcttcaagc tggagaagga ggtggccgag   1440

acccagcacg gcacagtgct ggtgcaggtg aagtacgagg gcaccgacgc cccctgtaag   1500

atccctttca gcacccagga tgagaagggc gtgacacaga acggcagact gatcaccgcc   1560

aaccccatcg tgaccgacaa ggagaagccc gtgaacatcg agaccgagcc ccccttcggc   1620

gagagctaca tcattgtggg agccggcgag aaggccctga agctgtcctg gttcaagaag   1680

ggcagcagca tcggcaagat gttcgaggcc accgccagag gcgccagaag aatggccatc   1740

ctgggcgata ccgcctggga cttcggctcc atcggcggcg tgttcacctc tgtgggcaag   1800

ctggtgcatc aggtgttcgg caccgcctac ggcgtgctgt tcagcggagt gagctggacc   1860

atgaagatcg gcatcggcat cctgctgaca tggctgggcc tgaattctag aagcgccagc   1920

ctgagcatga cctgtatcgc tgtgggcatg gtgaccctgt acctgggcgt gatggtgcag   1980

gcc                                                                 1983


<210>  6
<211>  1983
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 2 prME

<400>  6
ttccacctga ccaccaggaa cggcgagccc cacatgatcg tgagcagaca ggagaagggc     60

aagagcctgc tgttcaagac cgaggacggc gtgaacatgt gtaccctgat ggccatggac    120

ctgggcgagc tgtgcgagga caccatcacc tacaagtgtc ccttcctgag gcagaacgag    180

cccgaggaca tcgactgttg gtgtaacagc acaagcacct gggtgaccta cggcacctgc    240

accaccaccg gcgagcacag aagggagaag aggagcgtgg ccctggtgcc ccacgtgggc    300

atgggattgg aaaccagaac cgagacctgg atgagcagcg agggcgcttg gaagcatgcc    360

cagagaatcg agacctggat tctgagacac cccggcttca ccatcatggc cgccatcctg    420

gcctacacca tcggcaccac ccacttccag agagccctga tcttcatcct gctgaccgcc    480

gtggccccca gcatgaccat gagatgcatc ggcatcagca acagagactt cgtggagggc    540

gtgagcggcg gcagctgggt ggacatcgtg ctggagcacg gcagctgtgt gaccaccatg    600

gccaagaaca agcccacact ggacttcgag ctgatcaaga ccgaggccaa gcagcccgcc    660

accctgagaa agtactgtat cgaggccaag ctgaccaaca ccaccaccga cagcagatgc    720

cccacccagg gcgagcccag cctcaatgag gagcaggaca agagattcgt gtgtaagcac    780

agcatggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cggcatcgtg    840

acctgtgcca tgttcacatg caagaagaac atgaagggca aggtggtgca gcctgagaac    900

ctggagtaca ccatcgtgat cacccctcac tctggcgagg agcatgccgt gggcaacgac    960

accggcaagc acggcaagga gatcaagatc accccccaga gcagcatcac agaggccgag   1020

ctgaccggct acggcacagt gaccatggag tgtagcccta gaaccggcct ggatttcaac   1080

gagatggtgc tgctgcaaat ggagaacaag gcctggctgg tgcacagaca atggttcctg   1140

gatctgcctc tgccctggct gcctggcgcc gacacccagg gaagcaactg gattcagaag   1200

gagaccctgg tgaccttcaa gaacccccac gccaagaagc aggacgtggt ggtgctgggc   1260

agccaggagg gcgccatgca caccgccctg acaggcgcca ccgagatcca gatgagcagc   1320

ggcaacctgc tgttcaccgg ccatttgaaa tgtagactga gaatggataa gctgcagctg   1380

aagggcatgt cttacagcat gtgtacaggc aagttcaagg tggtgaagga gatcgccgag   1440

acccagcacg gcaccatcgt gatcagagtg cagtacgagg gcgatggcag cccctgtaag   1500

atccccttcg agatcatgga tttggagaag agacacgtgc tgggcagact gatcaccgtg   1560

aaccccatcg tgaccgagaa ggatagcccc gtgaacatcg aggccgagcc ccctttcggc   1620

gacagctaca tcatcatcgg cgtggagccc ggccagctga agctgaactg gttcaagaag   1680

ggcagcagca tcggccagat gatcgagacc accatgagag gagccaagcg gatggccatc   1740

ctgggcgaca ccgcctggga cttcggctct ctgggcggcg tgttcacctc catcggcaag   1800

gccctgcacc aggtgttcgg cgccatctac ggcgccgcct tctccggcgt gtcctggacc   1860

atgaagatcc tgatcggcgt gatcatcacc tggatcggca tgaattccag aagcaccagc   1920

ctgagcgtgt ccctggtgct ggtcggagtg gtgaccctgt acctgggcgt gatggtgcag   1980

gcc                                                                 1983


<210>  7
<211>  1977
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 3 prME

<400>  7
ttccatctga ccagcagaga cggcgagccc agaatgatcg tgggcaagaa cgagagaggc     60

aagagcctgc tgttcaagac cgccagcggc atcaacatgt gtaccctgat cgccatggac    120

ctgggcgaga tgtgtgacga caccgtgacc tacaagtgtc cccacatcac cgaggtggag    180

cccgaggaca tcgactgttg gtgtaacctg acaagcacct gggtgaccta cggcacatgc    240

aaccaggccg gcgagcacag aagggacaag agaagcgtgg ccctggcccc ccacgtgggc    300

atgggcctgg ataccagaac ccagacctgg atgagcgccg agggcgcttg gagacaggtg    360

gagaaggtgg agacctgggc cctgagacac cccggcttca ccatcctggc cctgttcctg    420

gcccattaca tcggcaccag cctgacccag aaggtggtga tcttcatcct gctgatgctg    480

gtgaccccca gcatgaccat gcggtgtgtg ggcgtgggca acagagattt cgtggagggc    540

ctgagcggcg ccacctgggt ggacgtggtg ctggagcacg gcggctgtgt gaccaccatg    600

gccaagaata agcccaccct ggatatcgag ctgcagaaga ccgaggccac ccagctggcc    660

accctgagaa agctgtgcat cgagggcaag atcaccaaca tcaccaccga cagccggtgt    720

cctacccaag gcgaggccat cctgcccgag gagcaggacc agaactacgt gtgcaagcac    780

acatatgtgg atagaggctg gggcaacggc tgtggcctgt tcggcaaggg cagcctggtg    840

acctgtgcca agttccaatg tctggagtct atcgagggca aggtggtgca gcacgagaac    900

ctgaagtaca ccgtgattat caccgtgcac accggcgacc agcaccaggt gggcaacgag    960

acccagggcg tgaccgccga gatcacctcc caggccagca cagccgaggc catcctgccc   1020

gagtacggca ccctgggcct ggagtgttcc cccaggaccg gcctggactt caatgagatg   1080

atcctgctga ccatgaagaa caaggcttgg atggtgcaca gacagtggtt cttcgacctg   1140

cccctgccct ggaccagcgg cgccaccacc aagaccccca catggaacag aaaggagctg   1200

ctggtgacct tcaagaacgc ccacgccaag aagcaggagg tggtggtgct gggcagccaa   1260

gagggcgcca tgcacaccgc cctgaccggc gccaccgaga tccagaccag cggcggcaca   1320

tctatcttcg ccggccactt gaaatgtaga ctgaagatgg acaagctgaa gctgaagggc   1380

atgagctacg ccatgtgcct gaacaccttc gtgttgaaaa aggaggtgag cgagacccag   1440

cacggcacca tcctgatcaa ggtggagtac aagggcgagg acgccccctg taagatccct   1500

ttcagcaccg aggatggcca gggcaaggcc cacaacggca gactgatcac cgccaacccc   1560

gtggtgacca agaaggagga gcccgtgaac atcgaggccg agcccccctt cggcgagagc   1620

aacatcgtga tcggcatcgg cgacaaggcc ctgaagatca actggtacag aaagggcagc   1680

agcatcggca agatgttcga ggccaccgcc aggggcgcca gaaggatggc tatcctgggc   1740

gacaccgcct gggacttcgg cagcgtgggc ggcgtgctga acagcctggg caagatggtg   1800

caccagatct tcggcagcgc ctacacagcc ctgttctccg gagtgagctg gatcatgaag   1860

atcggaatcg gcgtgctgct gacctggatc ggactgaatt ccaaaaacac cagcatgagc   1920

ttcagctgta tcgccatcgg catcatcacc ctgtacctgg gagtggtggt gcaggcc      1977


<210>  8
<211>  2043
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Dengue Virus serotype 4 prME

<400>  8
ggatccgcca ccatgaagtg tctgctgtac ctggccttcc tgttcatcgg cgtgaactgt     60

ttcagcctga gcaccagaga cggcgagccc ctgatgatcg tggccaagca cgagagaggc    120

agacccctgc tgttcaagac caccgagggc atcaacaagt gtaccctgat tgccatggat    180

ctgggcgaga tgtgtgagga caccgtgacc tacaagtgtc ccctgctggt gaacacagag    240

cccgaggaca tcgactgctg gtgtaacctg accagcacat gggtgatgta cggcacctgt    300

acccagagcg gcgagaggag acgggagaag agatccgtgg ccctgacccc tcacagcggc    360

atgggcttgg aaacaagggc tgagacctgg atgagcagcg agggcgcctg gaagcacgcc    420

cagagagtgg agagctggat tctgagaaac cctggcttcg ccctgctggc cggcttcatg    480

gcctacatga tcggccagac cggcatccag aggaccgtgt tcttcgtgct gatgatgctg    540

gtcgccccca gctacggcat gagatgtgtg ggcgtgggca accgggactt cgtggagggc    600

gtgagcggcg gcgcctgggt ggacctggtg ctggagcacg gcggctgtgt gaccaccatg    660

gcccagggca agcctacact ggacttcgag ctgaccaaga ccaccgccaa ggaggtggcc    720

ctgctgagaa cctactgtat cgaggccagc atcagcaaca tcaccaccgc caccaggtgt    780

cccacccaag gcgagcctta tttgaaagaa gagcaggacc agcagtacat ttgtagaaga    840

gacgtggtgg acagaggctg gggcaacggc tgtggcctgt tcggcaaggg cggcgtggtg    900

acctgcgcca agttcagctg tagcggcaag atcaccggca acctggtgca gatcgagaac    960

ctggagtaca ccgtggtggt gaccgtgcac aacggcgata cccacgccgt gggcaacgat   1020

accagcaacc acggcgtgac cgccatgatc acccccagaa gccccagcgt ggaggtgaag   1080

ctgcccgact acggcgagct gaccctggac tgcgagccca gaagcggcat cgacttcaac   1140

gagatgattt tgatgaaaat gaaaaagaag acctggctgg tgcacaagca atggttcctg   1200

gacctgcccc tgccctggac cgccggagcc gacaccagcg aggtgcactg gaattacaag   1260

gagagaatgg tgaccttcaa ggtgccccac gccaagagac aggacgtgac cgtgctgggc   1320

agccaggagg gcgccatgca cagcgccctg gccggcgcca ccgaggtgga tagcggcgac   1380

ggcaaccata tgttcgccgg ccacttgaaa tgcaaagtga ggatggagaa gctgagaatc   1440

aagggcatgt cctacacaat gtgtagcggc aagttcagca tcgataagga gatggccgag   1500

acccagcatg gcaccaccgt ggtgaaggtg aagtacgagg gcgccggcgc tccctgcaag   1560

gtgcccattg agatcagaga cgtgaacaag gagaaggtgg tgggcagaat catcagctct   1620

acccccctgg ccgagaacac caatagcgtg accaacatcg agctggagcc tcccttcgga   1680

gacagctaca tcgtgatcgg cgtgggcaac agcgccctga ccctgcactg gttcagaaag   1740

ggcagctcta tcggcaagat gttcgagtcc acatatagag gcgccaagag aatggccatc   1800

ctgggcgaga ccgcctggga tttcggcagc gtgggcggcc tgttcaccag cctgggcaag   1860

gccgtgcacc aggtgttcgg ctccgtgtac accaccatgt tcggcggcgt gagctggatg   1920

atccggattc tgatcggctt cctggtgctg tggatcggca cgaattccag aaacaccagc   1980

atggccatga cctgtatcgc cgtgggcgga atcaccctgt tcctgggatt caccgtgcag   2040

gcc                                                                 2043


