                         SEQUENCE LISTING

<110>  GENETHON
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  UTILISATION DE LA DECORINE POUR AUGMENTER LA MASSE MUSCULAIRE

<130>  G143-B-27287 PCT

<150>  FR09.01260
<151>  2009-03-18

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  human DCN (variant A)

<400>  1

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  2
<211>  250
<212>  PRT
<213>  artificial sequence 

<220>
<223>  human DCN (variant B)

<400>  2

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser 
65                  70                  75                  80  


Gly Ile Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile 
                85                  90                  95      


Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro 
            100                 105                 110         


Ser Leu Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp 
        115                 120                 125             


Ala Ala Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser 
    130                 135                 140                 


Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro 
145                 150                 155                 160 


His Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro 
                165                 170                 175     


Gly Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn 
            180                 185                 190         


Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His 
        195                 200                 205             


Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro 
    210                 215                 220                 


Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val 
225                 230                 235                 240 


Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
                245                 250 


<210>  3
<211>  212
<212>  PRT
<213>  artificial sequence

<220>
<223>  human DCN (variant C)

<400>  3

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Pro Pro Ser Leu Thr Glu Leu His 
65                  70                  75                  80  


Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly 
                85                  90                  95      


Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
            100                 105                 110         


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
        115                 120                 125             


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
    130                 135                 140                 


Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Val Val 
145                 150                 155                 160 


Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
                165                 170                 175     


Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile 
            180                 185                 190         


Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu 
        195                 200                 205             


Gly Asn Tyr Lys 
    210         


<210>  4
<211>  172
<212>  PRT
<213>  artificial sequence

<220>
<223>  human DCN (variant D)

<400>  4

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Val Val Tyr Leu 
            100                 105                 110         


His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro 
        115                 120                 125             


Gly His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser 
    130                 135                 140                 


Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val 
145                 150                 155                 160 


Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
                165                 170         


<210>  5
<211>  75
<212>  PRT
<213>  artificial sequence

<220>
<223>  human DCN (variant E)

<400>  5

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Cys Leu Pro Ser 
65                  70                  75  


<210>  6
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  murine DCN

<400>  6

Met Lys Ala Thr Leu Ile Phe Phe Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
        35                  40                  45              


Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
    50                  55                  60                  


Leu Gly Leu Asp Lys Val Pro Trp Asp Phe Pro Pro Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                85                  90                  95      


Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
            100                 105                 110         


Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
        115                 120                 125             


Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro 
    130                 135                 140                 


Arg Thr Leu Gln Glu Leu Arg Val His Glu Asn Glu Ile Thr Lys Leu 
145                 150                 155                 160 


Arg Lys Ser Asp Phe Asn Gly Leu Asn Asn Val Leu Val Ile Glu Leu 
                165                 170                 175     


Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Phe Gln 
            180                 185                 190         


Gly Leu Lys Ser Leu Ser Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
        195                 200                 205             


Ala Ile Pro Gln Gly Leu Pro Thr Ser Leu Thr Glu Val His Leu Asp 
    210                 215                 220                 


Gly Asn Lys Ile Thr Lys Val Asp Ala Pro Ser Leu Lys Gly Leu Ile 
225                 230                 235                 240 


Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Met Glu 
                245                 250                 255     


Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
            260                 265                 270         


Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
        275                 280                 285             


Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Ala Val Gly Gln 
    290                 295                 300                 


Asn Asp Phe Cys Arg Ala Gly His Pro Ser Arg Lys Ala Ser Tyr Ser 
305                 310                 315                 320 


Ala Val Ser Leu Tyr Gly Asn Pro Val Arg Tyr Trp Glu Ile Phe Pro 
                325                 330                 335     


Asn Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn 
            340                 345                 350         


Tyr Lys 
        


<210>  7
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  murine 31-71 DCN

<400>  7

Asp Glu Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile 
1               5                   10                  15      


Ser Met Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys 
            20                  25                  30          


Ser Asp Leu Gly Leu Asp Lys Val Pro 
        35                  40      


<210>  8
<211>  2305
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant A1 human DCN

<400>  8
gaatctacaa taagacaaat ttcaaatcaa gttgctccac tatactgcat aagcagttta     60

gaatcttaag cagatgcaaa aagaataaag caaatgggag gaaaaaaaag gccgataaag    120

tttctggcta caatacaaga gacatatcat taccatatga tctaatgtgg gtgtcagccg    180

gattgtgttc attgagggaa accttatttt ttaactgtgc tatggagtag aagcaggagg    240

ttttcaacct agtcacagag cagcacctac cccctcctcc tttccacacc tgcaaactct    300

tttacttggg ctgaatattt agtgtaatta catctcagct ttgagggctc ctgtggcaaa    360

ttcccggatt aaaaggttcc ctggttgtga aaatacatga gataaatcat gaaggccact    420

atcatcctcc ttctgcttgc acaagtttcc tgggctggac cgtttcaaca gagaggctta    480

tttgacttta tgctagaaga tgaggcttct gggataggcc cagaagttcc tgatgaccgc    540

gacttcgagc cctccctagg cccagtgtgc cccttccgct gtcaatgcca tcttcgagtg    600

gtccagtgtt ctgatttggg tctggacaaa gtgccaaagg atcttccccc tgacacaact    660

ctgctagacc tgcaaaacaa caaaataacc gaaatcaaag atggagactt taagaacctg    720

aagaaccttc acgcattgat tcttgtcaac aataaaatta gcaaagttag tcctggagca    780

tttacacctt tggtgaagtt ggaacgactt tatctgtcca agaatcagct gaaggaattg    840

ccagaaaaaa tgcccaaaac tcttcaggag ctgcgtgccc atgagaatga gatcaccaaa    900

gtgcgaaaag ttactttcaa tggactgaac cagatgattg tcatagaact gggcaccaat    960

ccgctgaaga gctcaggaat tgaaaatggg gctttccagg gaatgaagaa gctctcctac   1020

atccgcattg ctgataccaa tatcaccagc attcctcaag gtcttcctcc ttcccttacg   1080

gaattacatc ttgatggcaa caaaatcagc agagttgatg cagctagcct gaaaggactg   1140

aataatttgg ctaagttggg attgagtttc aacagcatct ctgctgttga caatggctct   1200

ctggccaaca cgcctcatct gagggagctt cacttggaca acaacaagct taccagagta   1260

cctggtgggc tggcagagca taagtacatc caggttgtct accttcataa caacaatatc   1320

tctgtagttg gatcaagtga cttctgccca cctggacaca acaccaaaaa ggcttcttat   1380

tcgggtgtga gtcttttcag caacccggtc cagtactggg agatacagcc atccaccttc   1440

agatgtgtct acgtgcgctc tgccattcaa ctcggaaact ataagtaatt ctcaagaaag   1500

ccctcatttt tataacctgg caaaatcttg ttaatgtcat tgctaaaaaa taaataaaag   1560

ctagatactg gaaacctaac tgcaatgtgg atgttttacc cacatgactt attatgcata   1620

aagccaaatt tccagtttaa gtaattgcct acaataaaaa gaaattttgc ctgccatttt   1680

cagaatcatc ttttgaagct ttctgttgat gttaactgag ctactagaga tattcttatt   1740

tcactaaatg taaaatttgg agtaaatata tatgtcaata tttagtaaag cttttctttt   1800

ttaatttcca ggaaaaaata aaaagagtat gagtcttctg taattcattg agcagttagc   1860

tcatttgaga taaagtcaaa tgccaaacac tagctctgta ttaatcccca tcattactgg   1920

taaagcctca tttgaatgtg tgaattcaat acaggctatg taaaattttt actaatgtca   1980

ttattttgaa aaaataaatt taaaaataca ttcaaaatta ctattgtata caagcttaat   2040

tgttaatatt ccctaaacac aattttatga agggagaaga cattggtttg ttgacaataa   2100

cagtacatct tttcaagttc tcagctattt cttctacctc tccctatctt acatttgagt   2160

atggtaactt atgtcatcta tgttgaatgt aagcttataa agcacaaagc atacatttcc   2220

tgactggtct agagaactga tgtttcaatt tacccctctg ctaaataaat attaaaacta   2280

tcatgtgaaa aaaaaaaaaa aaaaa                                         2305


<210>  9
<211>  2151
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant A2 human CN

<400>  9
ggaataataa gacacgccct gaaggagtac atcgtctagt gagggacaga ccaagcacgc     60

aaaacaaatt gcaatataat gtgataagtt ctttaaaaga ggtaagagca acgtgctttg    120

ggagcagaga agagggagaa agcagcatct tgcctggatg agccagggga cacagaagag    180

aagcccacta tctcatttaa tctttacaac tctcttgcaa ggttccctgg ttgtgaaaat    240

acatgagata aatcatgaag gccactatca tcctccttct gcttgcacaa gtttcctggg    300

ctggaccgtt tcaacagaga ggcttatttg actttatgct agaagatgag gcttctggga    360

taggcccaga agttcctgat gaccgcgact tcgagccctc cctaggccca gtgtgcccct    420

tccgctgtca atgccatctt cgagtggtcc agtgttctga tttgggtctg gacaaagtgc    480

caaaggatct tccccctgac acaactctgc tagacctgca aaacaacaaa ataaccgaaa    540

tcaaagatgg agactttaag aacctgaaga accttcacgc attgattctt gtcaacaata    600

aaattagcaa agttagtcct ggagcattta cacctttggt gaagttggaa cgactttatc    660

tgtccaagaa tcagctgaag gaattgccag aaaaaatgcc caaaactctt caggagctgc    720

gtgcccatga gaatgagatc accaaagtgc gaaaagttac tttcaatgga ctgaaccaga    780

tgattgtcat agaactgggc accaatccgc tgaagagctc aggaattgaa aatggggctt    840

tccagggaat gaagaagctc tcctacatcc gcattgctga taccaatatc accagcattc    900

ctcaaggtct tcctccttcc cttacggaat tacatcttga tggcaacaaa atcagcagag    960

ttgatgcagc tagcctgaaa ggactgaata atttggctaa gttgggattg agtttcaaca   1020

gcatctctgc tgttgacaat ggctctctgg ccaacacgcc tcatctgagg gagcttcact   1080

tggacaacaa caagcttacc agagtacctg gtgggctggc agagcataag tacatccagg   1140

ttgtctacct tcataacaac aatatctctg tagttggatc aagtgacttc tgcccacctg   1200

gacacaacac caaaaaggct tcttattcgg gtgtgagtct tttcagcaac ccggtccagt   1260

actgggagat acagccatcc accttcagat gtgtctacgt gcgctctgcc attcaactcg   1320

gaaactataa gtaattctca agaaagccct catttttata acctggcaaa atcttgttaa   1380

tgtcattgct aaaaaataaa taaaagctag atactggaaa cctaactgca atgtggatgt   1440

tttacccaca tgacttatta tgcataaagc caaatttcca gtttaagtaa ttgcctacaa   1500

taaaaagaaa ttttgcctgc cattttcaga atcatctttt gaagctttct gttgatgtta   1560

actgagctac tagagatatt cttatttcac taaatgtaaa atttggagta aatatatatg   1620

tcaatattta gtaaagcttt tcttttttaa tttccaggaa aaaataaaaa gagtatgagt   1680

cttctgtaat tcattgagca gttagctcat ttgagataaa gtcaaatgcc aaacactagc   1740

tctgtattaa tccccatcat tactggtaaa gcctcatttg aatgtgtgaa ttcaatacag   1800

gctatgtaaa atttttacta atgtcattat tttgaaaaaa taaatttaaa aatacattca   1860

aaattactat tgtatacaag cttaattgtt aatattccct aaacacaatt ttatgaaggg   1920

agaagacatt ggtttgttga caataacagt acatcttttc aagttctcag ctatttcttc   1980

tacctctccc tatcttacat ttgagtatgg taacttatgt catctatgtt gaatgtaagc   2040

ttataaagca caaagcatac atttcctgac tggtctagag aactgatgtt tcaatttacc   2100

cctctgctaa ataaatatta aaactatcat gtgaaaaaaa aaaaaaaaaa a            2151


<210>  10
<211>  1570
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variant B human DCN

<400>  10
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa     60

cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt    120

cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc    180

catcttcgag tggtccagtg ttctgatttg gaactgggca ccaatccgct gaagagctca    240

ggaattgaaa atggggcttt ccagggaatg aagaagctct cctacatccg cattgctgat    300

accaatatca ccagcattcc tcaaggtctt cctccttccc ttacggaatt acatcttgat    360

ggcaacaaaa tcagcagagt tgatgcagct agcctgaaag gactgaataa tttggctaag    420

ttgggattga gtttcaacag catctctgct gttgacaatg gctctctggc caacacgcct    480

catctgaggg agcttcactt ggacaacaac aagcttacca gagtacctgg tgggctggca    540

gagcataagt acatccaggt tgtctacctt cataacaaca atatctctgt agttggatca    600

agtgacttct gcccacctgg acacaacacc aaaaaggctt cttattcggg tgtgagtctt    660

ttcagcaacc cggtccagta ctgggagata cagccatcca ccttcagatg tgtctacgtg    720

cgctctgcca ttcaactcgg aaactataag taattctcaa gaaagccctc atttttataa    780

cctggcaaaa tcttgttaat gtcattgcta aaaaataaat aaaagctaga tactggaaac    840

ctaactgcaa tgtggatgtt ttacccacat gacttattat gcataaagcc aaatttccag    900

tttaagtaat tgcctacaat aaaaagaaat tttgcctgcc attttcagaa tcatcttttg    960

aagctttctg ttgatgttaa ctgagctact agagatattc ttatttcact aaatgtaaaa   1020

tttggagtaa atatatatgt caatatttag taaagctttt cttttttaat ttccaggaaa   1080

aaataaaaag agtatgagtc ttctgtaatt cattgagcag ttagctcatt tgagataaag   1140

tcaaatgcca aacactagct ctgtattaat ccccatcatt actggtaaag cctcatttga   1200

atgtgtgaat tcaatacagg ctatgtaaaa tttttactaa tgtcattatt ttgaaaaaat   1260

aaatttaaaa atacattcaa aattactatt gtatacaagc ttaattgtta atattcccta   1320

aacacaattt tatgaaggga gaagacattg gtttgttgac aataacagta catcttttca   1380

agttctcagc tatttcttct acctctccct atcttacatt tgagtatggt aacttatgtc   1440

atctatgttg aatgtaagct tataaagcac aaagcataca tttcctgact ggtctagaga   1500

actgatgttt caatttaccc ctctgctaaa taaatattaa aactatcatg tgaaaaaaaa   1560

aaaaaaaaaa                                                          1570


<210>  11
<211>  1456
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant C human DCN

<400>  11
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa     60

cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt    120

cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc    180

catcttcgag tggtccagtg ttctgatttg ggtcttcctc cttcccttac ggaattacat    240

cttgatggca acaaaatcag cagagttgat gcagctagcc tgaaaggact gaataatttg    300

gctaagttgg gattgagttt caacagcatc tctgctgttg acaatggctc tctggccaac    360

acgcctcatc tgagggagct tcacttggac aacaacaagc ttaccagagt acctggtggg    420

ctggcagagc ataagtacat ccaggttgtc taccttcata acaacaatat ctctgtagtt    480

ggatcaagtg acttctgccc acctggacac aacaccaaaa aggcttctta ttcgggtgtg    540

agtcttttca gcaacccggt ccagtactgg gagatacagc catccacctt cagatgtgtc    600

tacgtgcgct ctgccattca actcggaaac tataagtaat tctcaagaaa gccctcattt    660

ttataacctg gcaaaatctt gttaatgtca ttgctaaaaa ataaataaaa gctagatact    720

ggaaacctaa ctgcaatgtg gatgttttac ccacatgact tattatgcat aaagccaaat    780

ttccagttta agtaattgcc tacaataaaa agaaattttg cctgccattt tcagaatcat    840

cttttgaagc tttctgttga tgttaactga gctactagag atattcttat ttcactaaat    900

gtaaaatttg gagtaaatat atatgtcaat atttagtaaa gcttttcttt tttaatttcc    960

aggaaaaaat aaaaagagta tgagtcttct gtaattcatt gagcagttag ctcatttgag   1020

ataaagtcaa atgccaaaca ctagctctgt attaatcccc atcattactg gtaaagcctc   1080

atttgaatgt gtgaattcaa tacaggctat gtaaaatttt tactaatgtc attattttga   1140

aaaaataaat ttaaaaatac attcaaaatt actattgtat acaagcttaa ttgttaatat   1200

tccctaaaca caattttatg aagggagaag acattggttt gttgacaata acagtacatc   1260

ttttcaagtt ctcagctatt tcttctacct ctccctatct tacatttgag tatggtaact   1320

tatgtcatct atgttgaatg taagcttata aagcacaaag catacatttc ctgactggtc   1380

tagagaactg atgtttcaat ttacccctct gctaaataaa tattaaaact atcatgtgaa   1440

aaaaaaaaaa aaaaaa                                                   1456


<210>  12
<211>  1336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  variant D human DCN

<400>  12
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa     60

cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt    120

cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc    180

catcttcgag tggtccagtg ttctgatttg ggtctggaca aagtgccaaa ggatcttccc    240

cctgacacaa ctctgctaga cctgcaaaac aacaaaataa ccgaaatcaa agatggagac    300

tttaagaacc tgaagaacct tcacgttgtc taccttcata acaacaatat ctctgtagtt    360

ggatcaagtg acttctgccc acctggacac aacaccaaaa aggcttctta ttcgggtgtg    420

agtcttttca gcaacccggt ccagtactgg gagatacagc catccacctt cagatgtgtc    480

tacgtgcgct ctgccattca actcggaaac tataagtaat tctcaagaaa gccctcattt    540

ttataacctg gcaaaatctt gttaatgtca ttgctaaaaa ataaataaaa gctagatact    600

ggaaacctaa ctgcaatgtg gatgttttac ccacatgact tattatgcat aaagccaaat    660

ttccagttta agtaattgcc tacaataaaa agaaattttg cctgccattt tcagaatcat    720

cttttgaagc tttctgttga tgttaactga gctactagag atattcttat ttcactaaat    780

gtaaaatttg gagtaaatat atatgtcaat atttagtaaa gcttttcttt tttaatttcc    840

aggaaaaaat aaaaagagta tgagtcttct gtaattcatt gagcagttag ctcatttgag    900

ataaagtcaa atgccaaaca ctagctctgt attaatcccc atcattactg gtaaagcctc    960

atttgaatgt gtgaattcaa tacaggctat gtaaaatttt tactaatgtc attattttga   1020

aaaaataaat ttaaaaatac attcaaaatt actattgtat acaagcttaa ttgttaatat   1080

tccctaaaca caattttatg aagggagaag acattggttt gttgacaata acagtacatc   1140

ttttcaagtt ctcagctatt tcttctacct ctccctatct tacatttgag tatggtaact   1200

tatgtcatct atgttgaatg taagcttata aagcacaaag catacatttc ctgactggtc   1260

tagagaactg atgtttcaat ttacccctct gctaaataaa tattaaaact atcatgtgaa   1320

aaaaaaaaaa aaaaaa                                                   1336


<210>  13
<211>  1223
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant E human DCN

<400>  13
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa     60

cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt    120

cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc    180

catcttcgag tggtccagtg ttctgatttg ggttgtctac cttcataaca acaatatctc    240

tgtagttgga tcaagtgact tctgcccacc tggacacaac accaaaaagg cttcttattc    300

gggtgtgagt cttttcagca acccggtcca gtactgggag atacagccat ccaccttcag    360

atgtgtctac gtgcgctctg ccattcaact cggaaactat aagtaattct caagaaagcc    420

ctcattttta taacctggca aaatcttgtt aatgtcattg ctaaaaaata aataaaagct    480

agatactgga aacctaactg caatgtggat gttttaccca catgacttat tatgcataaa    540

gccaaatttc cagtttaagt aattgcctac aataaaaaga aattttgcct gccattttca    600

gaatcatctt ttgaagcttt ctgttgatgt taactgagct actagagata ttcttatttc    660

actaaatgta aaatttggag taaatatata tgtcaatatt tagtaaagct tttctttttt    720

aatttccagg aaaaaataaa aagagtatga gtcttctgta attcattgag cagttagctc    780

atttgagata aagtcaaatg ccaaacacta gctctgtatt aatccccatc attactggta    840

aagcctcatt tgaatgtgtg aattcaatac aggctatgta aaatttttac taatgtcatt    900

attttgaaaa aataaattta aaaatacatt caaaattact attgtataca agcttaattg    960

ttaatattcc ctaaacacaa ttttatgaag ggagaagaca ttggtttgtt gacaataaca   1020

gtacatcttt tcaagttctc agctatttct tctacctctc cctatcttac atttgagtat   1080

ggtaacttat gtcatctatg ttgaatgtaa gcttataaag cacaaagcat acatttcctg   1140

actggtctag agaactgatg tttcaattta cccctctgct aaataaatat taaaactatc   1200

atgtgaaaaa aaaaaaaaaa aaa                                           1223


<210>  14
<211>  1065
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Murine DCN

<400>  14
atgaaggcaa ctctcatctt cttccttctg gcacaagtct cttgggctgg accatttgaa     60

cagagaggct tatttgactt catgctagaa gatgaggctt ctggcataat cccttatgac    120

cctgacaatc ccctgatatc tatgtgcccc taccgatgcc agtgtcatct tcgagtggtg    180

cagtgttctg atctgggttt ggacaaagtg ccctgggatt ttccacccga cacaaccttg    240

ctagacctgc aaaacaacaa aattacagag atcaaagaag gggccttcaa gaacctgaag    300

gacttgcata ccttgatcct tgtcaacaac aagatcagca aaatcagtcc agaggcattc    360

aaacctctcg tgaagttgga aaggctttac ctgtctaaga accaactaaa ggaactgcct    420

gaaaaaatgc ccagaactct ccaggaactt cgtgtccatg agaatgagat caccaagctg    480

cggaaatccg acttcaatgg actgaacaat gtgcttgtca tagaactggg cggcaaccca    540

ctgaaaaact ctgggattga aaacggagcc ttccagggac tgaagagtct ctcatacatt    600

cgcatctcag acaccaacat aactgcgatc cctcaaggtc tgcctacttc tctcactgaa    660

gtgcatctag atggcaacaa gatcaccaag gttgatgcac ccagcctgaa aggactgatt    720

aatttgtcta aactgggatt gagcttcaac agcatcaccg ttatggagaa tggcagtctg    780

gccaatgttc ctcatctgag ggaactccac ttggacaaca acaaactcct cagggtgcct    840

gctgggctgg cacagcataa gtatatccag gtcgtctacc ttcacaacaa caacatctcc    900

gcagttgggc aaaatgactt ctgccgagct ggacacccct ctcgaaaggc ttcctactcg    960

gctgtgagtc tttacggcaa ccctgtccgg tattgggaaa tctttccaaa caccttcaga   1020

tgtgtctatg tgcgttctgc cattcaactt ggaaactaca agtaa                   1065


<210>  15
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  murine 42-71 DCN

<400>  15

Asp Asn Pro Leu Ile Ser Met Cys Pro Tyr Arg Cys Gln Cys His Leu 
1               5                   10                  15      


Arg Val Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro 
            20                  25                  30  


<210>  16
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  human DCN fragment

<400>  16

Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro Ser Leu Gly 
1               5                   10                  15      


Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val Val Gln Cys 
            20                  25                  30          


Ser Asp Leu Gly Leu Asp Lys Val Pro 
        35                  40      


