                         SEQUENCE LISTING

<110>  VIB VZW
       UNIVERSITEIT GENT
       UNIVERSITE DU LUXEMBOURG
 
<120>  PLASTIN ANTIBODIES AND THEIR USE

<130>  JGE/PLA/V309

<150>  US 61/210,819
<151>  2009-03-23

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  1

Gly Gly Thr Phe Gly Arg Val Gly Val Gly 
1               5                   10  


<210>  2
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Asn Lys His Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Val Pro Met Asn Gly Thr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys His Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Val Pro Met Asn Gly Thr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys His Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Ala Pro Met Asn Gly Ala Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys Asp Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Ala Pro Met Ser Gly Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  6
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys Asp Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Ala Pro Met Ser Gly Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Gly Arg Val 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asn Trp Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys Asp Thr Val Asp 
65                  70                  75                  80  


Leu Arg Met Tyr Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Phe Arg Phe Asn Ala Pro Met Ser Gly Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Trp Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ser Ser Thr Leu Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ala Ile Thr Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Asp Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Phe Asp Asn Leu Leu Asn Thr Ala Thr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Asp Arg Val Gly Ala Trp Asp His Gln Pro Leu Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ala Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val 
        35                  40                  45              


Ala Ile Ile Ala Ser Gly Gly Phe Thr Tyr Tyr Gly Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Arg Asp Asp Ala Lys Asn Thr Trp Asn Leu 
65                  70                  75                  80  


Glu Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Phe Ile Arg Thr Val Val Asp Gly Pro Leu Tyr Asn Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Arg 
        115                 120     


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Phe Asn 
            20                  25                  30          


Ile Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Val Val Arg Glu Gln Ile His Asn Tyr Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
tcgaattcgc caccatgcag gtgcagctgc aggag                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
atgactgatg gatccttgct ggagacggtg acctg                                  35


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n can be A or G

<400>  13
gatgtgcagc tgcaggagtc tgganggagg                                        30


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
ggactagtgc ggccgctgga gacggtgacc tgggt                                  35


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
ggtttaaacg ccaccatggc ccaggtgcag ctgcaggagt ctggg                       45


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
gccactagtt gctcggccgg aaccgtagtc cgg                                    33


<210>  17
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ctcgagatga agtcattcat cactcgtaac aagactgcaa tcctagc                     47


<210>  18
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
tacggtcgct gcaactggta ccgctatcgg agcttactat tactata                     47


<210>  19
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
gattgcagtc ttgttacgag tgatgaatga cttcatctcg aga                         43


<210>  20
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
atagtaatag taagctccga tagcggtacc agttgcagcg accgtagcta g                51


<210>  21
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
cgtaccggtg cccaggtgca gctgcaggag tctgg                                  35


<210>  22
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
cgtaccggtc tagctggaga cggtgacctg ggtc                                   34


