                         SEQUENCE LISTING

<110>  Academia Sinica
 
<120>  METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST INFLUENZA

<130>  OPK-50101

<150>  US 61/164,385
<151>  2009-03-27

<150>  US 61/164,387
<151>  2009-03-28

<150>  US 61/164,388
<151>  2009-03-28

<150>  US 61/164,389
<151>  2009-03-28

<150>  US 61/313,676
<151>  2010-03-12

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly 
1               5                   10      


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Pro Gln Arg Glu Arg Gly 
1               5       


<210>  3
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro 
1               5                   10                  15      


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
            20                  25                  30          


Ser Thr Phe Leu Gly His His His His His His 
        35                  40              


<210>  4
<211>  564
<212>  PRT
<213>  Influenza A virus

<400>  4

Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Ser His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu 
            340                 345                 350         


Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser 
        355                 360                 365             


Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys 
    370                 375                 380                 


Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met 
385                 390                 395                 400 


Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg 
                405                 410                 415     


Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val 
            420                 425                 430         


Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr 
        435                 440                 445             


Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg 
    450                 455                 460                 


Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu 
465                 470                 475                 480 


Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly 
                485                 490                 495     


Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu 
            500                 505                 510         


Glu Ile Ser Gly Val Asp Ile Arg Ser Leu Val Pro Arg Gly Ser Pro 
        515                 520                 525             


Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
    530                 535                 540                 


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His 
545                 550                 555                 560 


His His His His 
                


<210>  5
<211>  1695
<212>  DNA
<213>  Influenza A virus

<400>  5
atggagaaga tcgtgctgct gttcgccatc gtgagcctgg tgaagagcga ccagatctgc       60

atcggatccc acgccaacaa cagcaccgag caggtggaca ccatcatgga gaagaacgtg      120

accgtgaccc acgcccagga catcctggag aagacccaca acggcaagct gtgcgacctg      180

gacggcgtga agcctctgat cctgagagac tgcagcgtgg ccggctggct gctgggcaac      240

cctatgtgcg acgagttcat caacgtgcct gagtggagct acatcgtgga gaaggccaac      300

cctgccaacg acctgtgcta ccctggcgac ttcaacgact acgaggagct gaagcacctg      360

ctgagcagaa tcaaccactt cgagaagatc cagatcatcc ctaagagcag ctggagcagc      420

cacgaggcca gcagcggcgt gagcagcgcc tgcccttacc agggcaagag cagcttcttc      480

agaaacgtgg tgtggctgat caagaagaac agcacctacc ctaccatcaa gagaagctac      540

aacaacacca accaggagga cctgctggtg ctgtggggca tccaccaccc taacgacgcc      600

gccgagcaga ccaagctgta ccagaaccct accacctaca tcagcgtggg caccagcacc      660

ctgaaccaga gactggtgcc taagatcgcc accagaagca aggtgaacgg ccagagcggc      720

agaatggagt tcttctggac catcctgaag cctaacgacg ccatcaactt cgagagcaac      780

ggcaacttca tcgcccctga gtacgcctac aagatcgtga agaagggcga cagcaccatc      840

atgaagagcg agctggagta cggcaactgc aacaccaagt gccagacccc tatgggcgcc      900

atcaacagca gcatgccttt ccacaacatc caccctctga ccatcggcga gtgccctaag      960

tacgtgaaga gcaacagact ggtgctggcc accggcctga gaaacagccc tcagagagag     1020

agaggcctgt tcggcgccat cgccggcttc atcgagggcg gctggcaggg catggtggac     1080

ggctggtacg gctaccacca cagcaacgag cagggcagcg gctacgccgc cgacaaggag     1140

agcacccaga aggccatcga cggcgtgacc aacaaggtga acagcatcat cgacaagatg     1200

aacacccagt tcgaggccgt gggcagagag ttcaacaacc tggagagaag aatcgagaac     1260

ctgaacaaga agatggagga cggcttcctg gacgtgtgga cctacaacgc cgagctgctg     1320

gtgctgatgg agaacgagag aaccctggac ttccacgaca gcaacgtgaa gaacctgtac     1380

gacaaggtga gactgcagct gagagacaac gccaaggagc tgggcaacgg ctgcttcgag     1440

ttctaccaca agtgcgacaa cgagtgcatg gagagcgtga gaaacggcac ctacgactac     1500

cctcagtaca gcgaggaggc cagactgaag agagaggaga tcagcggcgt ggatatcaga     1560

tctctggtgc caagaggatc tccaggatct ggatacatcc cagaggctcc aagagatgga     1620

caagcttacg tgagaaagga cggagagtgg gtgctgctgt ctactttcct gggacaccac     1680

caccaccacc actaa                                                      1695


<210>  6
<211>  567
<212>  PRT
<213>  Influenza A virus

<400>  6

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Asp Ile Arg Ser Leu Val Pro Arg 
        515                 520                 525             


Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
    530                 535                 540                 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
545                 550                 555                 560 


Gly His His His His His His 
                565         


<210>  7
<211>  1720
<212>  DNA
<213>  Influenza A virus

<400>  7
atggcgcgcc gctagcatga aggccatcct ggttgtgctg ctgtacacct tcgctaccgc       60

caacgccgat accctgtgca tcggctacca cgccaacaac agcaccgaca ccgtggatac      120

cgtgctggaa aagaacgtga ccgtgaccca cagcgtgaac ctgctggaag ataagcacaa      180

cggcaagctg tgcaagctga gaggcgtggc ccctctgcac ctgggcaagt gcaatatcgc      240

cggctggatc ctgggcaacc ccgagtgcga gagcctgagc accgccagca gctggtccta      300

catcgtggag acacccagca gcgacaatgg cacctgttac cccggcgact tcatcgacta      360

cgaggaactg cgggagcagc tgagcagcgt gtccagcttc gagcggttcg agatcttccc      420

caagaccagc tcttggccca accacgacag caacaagggc gtgaccgccg cctgtcctca      480

cgctggcgcc aagagcttct acaagaacct gatctggctg gtcaagaagg gcaacagcta      540

ccccaaactg agcaagagct acatcaacga caagggcaaa gaagtgctgg tgctgtgggg      600

catccaccac cctagcacca gcgccgacca gcagagcctg taccagaacg ccgacgccta      660

cgtgttcgtg ggcagcagcc ggtacagcaa gaagttcaag cccgagatcg ccatcagacc      720

caaagtgcgg gaccaagagg gccggatgaa ctactactgg accctggtgg agcccggcga      780

caagatcacc ttcgaggcca ccggcaatct ggtcgtgccc agatacgcct tcgccatgga      840

aagaaacgcc ggcagcggca tcatcatcag cgacaccccc gtgcacgact gcaacaccac      900

ctgtcagacc cccaaaggcg ccatcaacac cagcctgccc ttccagaaca tccaccccat      960

caccatcggc aagtgcccta agtacgtgaa gtctaccaag ctgaggctgg ccacaggcct     1020

gcggaacatc cccagcatcc agagcagagg cctgtttggc gccattgccg gctttatcga     1080

gggcggctgg accggaatgg tggatggatg gtatggctac caccaccaga atgagcaggg     1140

aagcggctac gccgccgacc tgaagtccac acagaacgcc atcgacgaga tcaccaacaa     1200

agtgaactca gtgatcgaga agatgaacac ccagttcacc gccgtgggca aagaattcaa     1260

ccacctggaa aagcggatcg agaacctgaa caagaaggtg gacgacggct tcctggacat     1320

ctggacctac aacgccgagc tgctcgtgct gctggaaaac gagcggaccc tggactacca     1380

cgactccaac gtgaagaatc tgtacgagaa agttcgctcc cagctgaaga acaacgccaa     1440

agagatcggc aacggctgct tcgagttcta ccacaagtgc gacaacacct gtatggaaag     1500

cgtgaagaac ggcacctacg actaccccaa gtacagcgag gaagccaagc tgaaccggga     1560

agagatcgac ggcgtggata tcagatctct ggtgccaaga ggatctccag gatctggata     1620

catcccagag gctccaagag atggacaagc ttacgtgaga aaggacggag agtgggtgct     1680

gctgtctact ttcctgggac accaccacca ccaccactaa                           1720


<210>  8
<211>  567
<212>  PRT
<213>  Influenza A virus

<400>  8

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Asp Ile Arg Ser Leu Val Pro Arg 
        515                 520                 525             


Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
    530                 535                 540                 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
545                 550                 555                 560 


Gly His His His His His His 
                565         


<210>  9
<211>  1704
<212>  DNA
<213>  Influenza A virus

<400>  9
atgaaggtga aactgctggt gctgctgtgc accttcaccg ccacctacgc cgacaccatc       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggaaaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaagatagcc acaacggcaa gctgtgcctg      180

ctgaagggca ttgcccccct gcagctgggc aactgtagcg tggccggctg gattctgggc      240

aaccccgagt gcgagctgct gatcagcaaa gagtcctggt cctacatcgt ggagacaccc      300

aaccccgaga acggcacctg ttaccccggc tacttcgccg actacgagga actgagagag      360

cagctgtcct ctgtctccag cttcgagcgg ttcgagatct tccccaaaga gagcagctgg      420

cccaaccaca ccgtgacaaa gggcgtgagc gccagctgct cccacaatgg caagagcagc      480

ttctaccgga acctgctgtg gctgaccggc aagaacggcc tgtaccccaa cctgagcaag      540

agctatgcca acaacaaaga gaaagaggtc ctcgtcctct ggggcgtgca ccaccccccc      600

aacatcggcg accagcgggc cctgtaccac accgagaacg cctacgtgtc cgtggtgtcc      660

agccactaca gcagacggtt cacccccgag atcgccaaga ggcccaaagt gcgggaccag      720

gaaggccgga tcaactacta ctggaccctg ctggaacccg gcgacaccat catcttcgag      780

gccaacggca acctgatcgc ccccagatac gcctttgccc tgagcagagg cttcggcagc      840

ggcatcatca ccagcaacgc ccccatggac gagtgcgacg ccaagtgtca gaccccccag      900

ggcgccatca acagcagcct gcccttccag aacgtgcacc ccgtgaccat cggcgagtgc      960

cctaagtacg tgcggagcac caagctgaga atggtgaccg gcctgcggaa catccccagc     1020

atccagagca gaggcctgtt tggcgccatt gccggcttta tcgagggcgg ctggaccgga     1080

atggtggacg ggtggtacgg ctaccaccac cagaatgagc agggcagcgg ctacgccgcc     1140

gatcagaagt ccacccagaa cgctatcaac ggcatcacca acaaagtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaagagt tcaacaagct ggaacggcgg     1260

atggaaaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tcctgctgga aaacgagcgg accctggact tccacgacag caacgtgaag     1380

aacctgtacg agaaagtgaa gtcccagctg aagaacaacg ccaaagagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcaacgac gagtgcatgg aaagcgtgaa gaacggcaca     1500

tacgactacc ccaagtacag cgaggaaagc aagctgaacc gggagaagat cgacggcgtg     1560

gatatcagat ctctggtgcc aagaggatct ccaggatctg gatacatccc agaggctcca     1620

agagatggac aagcttacgt gagaaaggac ggagagtggg tgctgctgtc tactttcctg     1680

ggacaccacc accaccacca ctaa                                            1704


<210>  10
<211>  567
<212>  PRT
<213>  Influenza A virus

<400>  10

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Thr Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro 
        275                 280                 285             


Met Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Asp Ile Arg Ser Leu Val Pro Arg 
        515                 520                 525             


Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
    530                 535                 540                 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
545                 550                 555                 560 


Gly His His His His His His 
                565         


<210>  11
<211>  1704
<212>  DNA
<213>  Influenza A virus

<400>  11
atgaaggtga aactgctggt gctgctgtgc accttcaccg ccacctacgc cgacaccatc       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggaaaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaagatagcc acaacggcaa gctgtgcctg      180

ctgaagggca ttgcccccct gcagctgggc aactgtagcg tggccggctg gattctgggc      240

aaccccgagt gcgagctgct gatctccaaa gagtcctggt cttacatcgt ggagacaccc      300

aaccccgaga acggcacctg ttaccccggc cacttcgccg actacgagga actgcgggag      360

cagctgagca gcgtgtccag cttcgagcgg ttcgagatct tccccaaaga gagcagctgg      420

cccaaccacg ataccgtgac cggcgtgagc gccagctgtt cccacaacgg cgagagcagc      480

ttctaccgga acctgctgtg gctgaccggc aagaacggcc tgtaccccaa cctgagcaag      540

agctatgcca acaacaaaga gaaggaagtc ctggtcctct ggggcgtgca ccaccccccc      600

aacatcggcg accagaaggc cctgtaccac accgagaacg cctacgtgtc cgtggtgtcc      660

agccactaca gccggaagtt cacccccgag atcgccaaga ggcccaaagt gcgggaccag      720

gaaggccgga tcaactacta ctggaccctg ctggaacccg gcgacaccat catcttcgag      780

gccaacggca acctgatcgc ccccagatac gcctttgccc tgagcagagg cttcggcagc      840

ggcatcatca acagcaacgc ccccatggac aagtgcgacg ccaagtgcca gacaccccag      900

ggcgccatca acagctccct gcccttccag aacgtgcacc ccgtgaccat cggcgagtgc      960

cctaagtacg tgcggagcgc caagctgaga atggtgaccg gcctgcggaa catccccagc     1020

atccagagca gaggcctgtt tggcgccatt gccggcttta tcgagggcgg ctggaccgga     1080

atggtggacg ggtggtacgg ctaccaccac cagaatgagc agggcagcgg ctacgccgcc     1140

gatcagaagt ccacccagaa cgccatcaac ggcatcacca acaaagtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaagagt tcaacaagct ggaacggcgg     1260

atggaaaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga aaacgagcgg accctggact tccacgacag caacgtgaag     1380

aacctgtacg agaaagtgaa gtcccagctg aagaacaacg ccaaagagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcaacgac gagtgcatgg aaagcgtgaa gaacggcaca     1500

tacgactacc ccaagtacag cgaggaaagc aagctgaacc gggagaagat cgacggcgtg     1560

gatatcagat ctctggtgcc aagaggatct ccaggatctg gatacatccc agaggctcca     1620

agagatggac aagcttacgt gagaaaggac ggagagtggg tgctgctgtc tactttcctg     1680

ggacaccacc accaccacca ctaa                                            1704


<210>  12
<211>  298
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  12

Met Ser Lys Asn Lys Asp Gln Arg Thr Thr Lys Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Thr Thr Ser Gln Thr Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Ser Val Lys Ser Thr Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Lys Ile Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Ile 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Lys Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Arg Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Glu His Thr Ser Gln Lys Gly Thr Leu His Ser Thr Ser Ser Asp Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Tyr Thr Thr Ser Glu Tyr Leu Ser Gln 
        275                 280                 285             


Pro Pro Ser Pro Ser Asn Thr Thr Asn Gln 
    290                 295             


<210>  13
<211>  495
<212>  PRT
<213>  Dengue virus

<400>  13

Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Leu Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr 
145                 150                 155                 160 


Ile Ala Thr Ile Thr Pro Gln Ala Pro Met Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Val Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Thr Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Ile 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Thr Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Ile Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Ala Phe Thr Ser Val 
            420                 425                 430         


Gly Lys Leu Val His Gln Val Phe Gly Thr Ala Tyr Gly Val Leu Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr 
    450                 455                 460                 


Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Val Val Gln Ala 
                485                 490                 495 


<210>  14
<211>  192
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Ala Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys 
1               5                   10                  15      


Thr Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val 
            20                  25                  30          


Pro Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp 
        35                  40                  45              


Ile Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr 
    50                  55                  60                  


Gln Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu 
65                  70                  75                  80  


Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala 
                85                  90                  95      


Ala Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp 
            100                 105                 110         


Cys Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala 
        115                 120                 125             


Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala 
    130                 135                 140                 


Tyr Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala 
145                 150                 155                 160 


His Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala 
                165                 170                 175     


Trp Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala 
            180                 185                 190         


<210>  15
<211>  478
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  15

Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
1               5                   10                  15      


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
            20                  25                  30          


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
        35                  40                  45              


Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
    50                  55                  60                  


Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
65                  70                  75                  80  


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser Leu 
                85                  90                  95      


Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser Gly 
            100                 105                 110         


Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
        115                 120                 125             


Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe Tyr 
    130                 135                 140                 


Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys Leu 
145                 150                 155                 160 


Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser 
                165                 170                 175     


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
            180                 185                 190         


Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn 
        195                 200                 205             


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr 
    210                 215                 220                 


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg 
225                 230                 235                 240 


Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 
                245                 250                 255     


Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
            260                 265                 270         


Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly 
        275                 280                 285             


Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys 
    290                 295                 300                 


Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe 
305                 310                 315                 320 


Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro 
                325                 330                 335     


Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
            340                 345                 350         


Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
        355                 360                 365             


Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro 
    370                 375                 380                 


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala 
385                 390                 395                 400 


Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn Ile 
                405                 410                 415     


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu Ser 
            420                 425                 430         


Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
        435                 440                 445             


Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala 
    450                 455                 460                 


Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
465                 470                 475             


