
                                SEQUENCE LISTING

<110> Qiao, Lixin
      Glicksman, Marcie
      Gainer, Thomas
      Lo,  Donald C.
      Stein,  Ross L.
      Choi,  Sungwoon
      Cuny,  Gregory D.

<120> Inhibiting Erythropoietin-Producing
  Hepatocellular Carcinoma B3 (EphB3) Kinase
  

<130> 05311-0066WO1

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 998
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu
 1               5                  10                  15      
Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro
            20                  25                  30          
Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val
        35                  40                  45              
Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu
    50                  55                  60                  
Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val
65                  70                  75                  80  
Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe
                85                  90                  95      
Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr
            100                 105                 110         
Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu
        115                 120                 125             
Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala
    130                 135                 140                 
Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile
145                 150                 155                 160 
Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr
                165                 170                 175     
Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala
            180                 185                 190         
Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe
        195                 200                 205             
Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu
    210                 215                 220                 
Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr
225                 230                 235                 240 
Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys
                245                 250                 255     
Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala
            260                 265                 270         
Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro
        275                 280                 285             
Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys
    290                 295                 300                 
Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys
305                 310                 315                 320 
His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys
                325                 330                 335     
Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu
            340                 345                 350         
Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg
        355                 360                 365             
Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly
    370                 375                 380                 
Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro
385                 390                 395                 400 
Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu
                405                 410                 415     
Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser
            420                 425                 430         
Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr
        435                 440                 445             
Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser
    450                 455                 460                 
Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn
465                 470                 475                 480 
Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly
                485                 490                 495     
Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly
            500                 505                 510         
Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val
        515                 520                 525             
Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser
    530                 535                 540                 
Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile
545                 550                 555                 560 
Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val
                565                 570                 575     
Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu
            580                 585                 590         
Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr
        595                 600                 605             
Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe
    610                 615                 620                 
Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly
                645                 650                 655     
Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser
    690                 695                 700                 
Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp
705                 710                 715                 720 
Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met
            740                 745                 750         
Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu
    770                 775                 780                 
Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile
785                 790                 795                 800 
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr
                805                 810                 815     
Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met
            820                 825                 830         
Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile
        835                 840                 845             
Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro
    850                 855                 860                 
Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn
865                 870                 875                 880 
Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile
                885                 890                 895     
Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met
            900                 905                 910         
Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr
        915                 920                 925             
Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu
    930                 935                 940                 
Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met
945                 950                 955                 960 
Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln
                965                 970                 975     
Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln
            980                 985                 990         
Thr Leu Pro Val Gln Val
        995             


<210> 2
<211> 350
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr
 1               5                  10                  15      
Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Gly Ser Gln Tyr Ile Ala
            20                  25                  30          
Pro Gly Met Lys Val Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn
        35                  40                  45              
Glu Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Val Ser Cys Val Lys
    50                  55                  60                  
Ile Glu Glu Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Arg Gly
65                  70                  75                  80  
Arg Leu Lys Gln Pro Gly Arg Arg Glu Val Phe Val Ala Ile Lys Thr
                85                  90                  95      
Leu Lys Val Gly Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu
            100                 105                 110         
Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu
        115                 120                 125             
Gly Val Val Thr Lys Ser Arg Pro Val Met Ile Leu Thr Glu Phe Met
    130                 135                 140                 
Glu Asn Cys Ala Leu Asp Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe
145                 150                 155                 160 
Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met
                165                 170                 175     
Lys Tyr Leu Ser Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg
            180                 185                 190         
Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly
        195                 200                 205             
Leu Ser Arg Phe Leu Glu Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser
    210                 215                 220                 
Ser Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile
225                 230                 235                 240 
Ala Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile
                245                 250                 255     
Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met
            260                 265                 270         
Ser Asn Gln Asp Val Ile Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro
        275                 280                 285             
Pro Pro Met Asp Cys Pro Thr Ala Leu His Gln Leu Met Leu Asp Cys
    290                 295                 300                 
Trp Val Arg Asp Arg Asn Leu Arg Pro Lys Phe Ser Gln Ile Val Asn
305                 310                 315                 320 
Thr Leu Asp Lys Leu Ile Arg Asn Ala Ala Ser Leu Lys Val Ile Ala
                325                 330                 335     
Ser Ala Gln Ser Gly Met Ser Gln Pro Leu Leu Asp Arg Thr
            340                 345                 350 


<210> 3
<211> 541
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro
 1               5                  10                  15      
Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu
            20                  25                  30          
Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu
        35                  40                  45              
Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys
    50                  55                  60                  
Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn
65                  70                  75                  80  
Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu
                85                  90                  95      
Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser
            100                 105                 110         
Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu
        115                 120                 125             
Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn
    130                 135                 140                 
Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp
145                 150                 155                 160 
Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu
                165                 170                 175     
Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr
            180                 185                 190         
Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala
        195                 200                 205             
Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg
    210                 215                 220                 
His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro
225                 230                 235                 240 
Phe Thr Glu Phe Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu
                245                 250                 255     
Glu Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu
            260                 265                 270         
Lys Gln Pro Gly Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys
        275                 280                 285             
Val Gly Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
    290                 295                 300                 
Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val
305                 310                 315                 320 
Val Thr Lys Ser Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn
                325                 330                 335     
Cys Ala Leu Asp Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val
            340                 345                 350         
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr
        355                 360                 365             
Leu Ser Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
    370                 375                 380                 
Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
385                 390                 395                 400 
Arg Phe Leu Glu Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu
                405                 410                 415     
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr
            420                 425                 430         
Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met
        435                 440                 445             
Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn
    450                 455                 460                 
Gln Asp Val Ile Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro
465                 470                 475                 480 
Met Asp Cys Pro Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val
                485                 490                 495     
Arg Asp Arg Asn Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu
            500                 505                 510         
Asp Lys Leu Ile Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Lys
        515                 520                 525             
Gly Gly Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val
    530                 535                 540     


<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<220>
<221> PHOSPHORYLATION
<222> 14
<223> the site of phosphorylation

<400> 4
Ala Gly Ala Gly Leu Lys Lys Val Val Ala Leu Tyr Asp Tyr Met Pro
 1               5                  10                  15      
Met
    







