                         SEQUENCE LISTING

<110>  AlphaVax, Inc.
       Sloan Kettering Institute for Cancer Research
       Wolchok, Jedd D.
       Avogadri, Francesca
       Olmsted, Robert A.
       Maughan, Maureen
 
<120>  ALPHAVIRUS REPLICON PARTICLES EPXRESSING TRP2 AND  METHODS

<130>  41-09 WO

<140>  unassigned
<141>  2010-04-08

<150>  US 61/167,774
<151>  2009-04-08

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  517
<212>  PRT
<213>  Mus musculus

<400>  1

Met Gly Leu Val Gly Trp Gly Leu Leu Leu Gly Cys Leu Gly Cys Gly 
1               5                   10                  15      


Ile Leu Leu Arg Ala Arg Ala Gln Phe Pro Arg Val Cys Met Thr Leu 
            20                  25                  30          


Asp Gly Val Leu Asn Lys Glu Cys Cys Pro Pro Leu Gly Pro Glu Ala 
        35                  40                  45              


Thr Asn Ile Cys Gly Phe Leu Glu Gly Arg Gly Gln Cys Ala Glu Val 
    50                  55                  60                  


Gln Thr Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Gln Trp Pro Arg Lys Phe Phe Asn Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Gly Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asp Cys Asn Arg Lys Lys Pro Ala Ile Leu Arg Arg 
        115                 120                 125             


Asn Ile His Ser Leu Thr Ala Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Ser Ile His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Ile 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Lys Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Trp Leu Glu Arg Glu Leu Gln Arg Leu Thr Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Lys Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Asp Trp Leu Gly Ala Ala Arg Gln Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Thr Trp Glu Ile Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn Arg Arg Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Lys Val Gly Arg Asn Asn Glu Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asn Val Gln Asp Cys Leu Ser Leu Gln Lys Phe Asp Ser 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Asn Leu 
        355                 360                 365             


His Asn Leu Ala His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Val Phe Val Val Leu His Ser Phe Thr Asp 
385                 390                 395                 400 


Ala Ile Phe Asp Glu Trp Leu Lys Arg Asn Asn Pro Ser Thr Asp Ala 
                405                 410                 415     


Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn Met 
            420                 425                 430         


Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr Ala 
        435                 440                 445             


Glu Gln Leu Gly Tyr Asn Tyr Ala Val Asp Leu Ser Glu Glu Glu Ala 
    450                 455                 460                 


Pro Val Trp Ser Thr Thr Leu Ser Val Val Ile Gly Ile Leu Gly Ala 
465                 470                 475                 480 


Phe Val Leu Leu Leu Gly Leu Leu Ala Phe Leu Gln Tyr Arg Arg Leu 
                485                 490                 495     


Arg Lys Gly Tyr Ala Pro Leu Met Glu Thr Gly Leu Ser Ser Lys Arg 
            500                 505                 510         


Tyr Thr Glu Glu Ala 
        515         


<210>  2
<211>  1554
<212>  DNA
<213>  Mus musculus

<400>  2
atgggacttg taggatgggg acttttgttg ggatgtttgg gatgtggaat cctgctgcgc       60

gcccgagctc aattccccag agtgtgtatg acccttgacg gggtgctgaa caaagaatgc      120

tgtcctcccc tcggcccaga ggcaactaat atttgcggct tcttggaagg caggggacag      180

tgtgccgagg tccagaccga tacaaggccc tggtccgggc catacattct tcggaatcaa      240

gatgacaggg aacagtggcc tcggaagttc ttcaaccgga cctgcaaatg cacaggaaat      300

tttgcagggt ataattgcgg cggatgtaag ttcgggtgga ctggcccaga ttgtaataga      360

aagaagcctg ctatcctgag gcggaacatt cacagtttga cagctcagga gagagagcag      420

tttctgggtg ccctcgattt ggccaagaag agtattcatc ctgattatgt gataactact      480

caacattggc tgggactgct cggtccaaac gggacacaac ctcagatcgc caactgttct      540

gtgtacgact tcttcgtgtg gcttcactat tacagcgtcc gggacactct cctcggacct      600

gggcgccctt ataaagcaat cgacttctcc catcagggtc cagcatttgt cacttggcac      660

cgctaccatc tgctctggct tgagcgcgag ttgcagcgac tgaccgggaa tgagtcattt      720

gcactgcctt actggaattt tgcaacaggc aagaatgagt gtgatgtttg cactgatgat      780

tggctcggag ccgcaaggca ggatgaccct actctcatca gccggaatag ccggttttcc      840

acctgggaga ttgtgtgtga tagtttggat gactacaaca ggcgcgtgac actgtgtaat      900

gggacatacg agggactcct gcgccggaat aaggtgggac gcaacaatga aaagctgccc      960

acgctgaaga atgtgcagga ttgcctgagc cttcagaaat tcgattcccc accattcttt     1020

cagaactcca ccttctcttt tcgaaatgca cttgaggggt ttgacaaggc cgatgggact     1080

ttggattctc aggttatgaa tttgcacaat ctggcgcaca gcttcctgaa cggaaccaat     1140

gcattgccgc actccgctgc aaacgatccc gtgtttgtgg tcctccattc ctttacggac     1200

gctatatttg atgaatggtt gaaaagaaat aatccttcaa ccgacgcgtg gccccaagag     1260

cttgctccga ttggccataa caggatgtat aatatggtgc ccttctttcc tcccgtgact     1320

aatgaagagc ttttcttgac cgcagagcag ctcggctata attatgccgt agaccttagt     1380

gaggaagagg ctcccgtgtg gagcaccact ctctcagtgg tgatagggat cttgggcgcg     1440

tttgtactgc tgctgggcct gcttgccttc ttgcagtaca ggaggctgag gaagggatat     1500

gctcctttga tggaaaccgg tttgtctagc aaaagatata ccgaggaagc atga           1554


<210>  3
<211>  4743
<212>  DNA
<213>  Homo sapiens

<400>  3
aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata       60

ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg      120

acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc      180

ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca      240

tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa      300

ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga      360

taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta      420

taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct      480

gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa      540

ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg      600

ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg      660

aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac      720

aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg      780

cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag      840

agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat      900

caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa      960

ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt     1020

aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac     1080

ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga     1140

gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac     1200

agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag     1260

attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt     1320

gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa     1380

attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc     1440

cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga     1500

tgggactctg gattctcaag tgatgagcct tcataatttg gttcattcct tcctgaacgg     1560

gacaaacgct ttgccacatt cagccgccaa tgatcccatt tttgtggtga tttctaatcg     1620

tttgctttac aatgctacaa caaacatcct tgaacatgta agaaaagaga aagcgaccaa     1680

ggaactccct tccctgcatg tgctggttct tcattccttt actgatgcca tctttgatga     1740

gtggatgaaa agatttaatc ctcctgcaga tgcctggcct caggagctgg cccctattgg     1800

tcacaatcgg atgtacaaca tggttccttt cttccctcca gtgactaatg aagaactctt     1860

tttaacctca gaccaacttg gctacagcta tgccatcgat ctgccagttt cagttgaaga     1920

aactccaggt tggcccacaa ctctcttagt agtcatggga acactggtgg ctttggttgg     1980

tctttttgtg ctgttggctt ttcttcaata tagaagactt cgaaaaggat atacacccct     2040

aatggagaca catttaagca gcaagagata cacagaagaa gcctagggtg ctcatgcctt     2100

acctaagaga agaggctggc caagccacag ttctgacgct gacaataaag gaactaatcc     2160

tcactgttcc ttcttgagtt gaagatcttt gacataggtt cttctatagt gatgatgatc     2220

tcattcagaa gatgcttagc tgtagtttcc gctttgcttg cttgtttaac aaacccaact     2280

aaagtgcttg aggctacctc taccttcaaa taaagataga cctgacaatt tgtgatatct     2340

aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata     2400

ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg     2460

acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc     2520

ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca     2580

tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa     2640

ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga     2700

taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta     2760

taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct     2820

gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa     2880

ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg     2940

ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg     3000

aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac     3060

aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg     3120

cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag     3180

agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat     3240

caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa     3300

ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt     3360

aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac     3420

ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga     3480

gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac     3540

agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag     3600

attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt     3660

gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa     3720

attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc     3780

cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga     3840

tgggactctg gattctcaag tgatgagcct tcataatttg gttcattcct tcctgaacgg     3900

gacaaacgct ttgccacatt cagccgccaa tgatcccatt tttgtggtga tttctaatcg     3960

tttgctttac aatgctacaa caaacatcct tgaacatgta agaaaagaga aagcgaccaa     4020

ggaactccct tccctgcatg tgctggttct tcattccttt actgatgcca tctttgatga     4080

gtggatgaaa agatttaatc ctcctgcaga tgcctggcct caggagctgg cccctattgg     4140

tcacaatcgg atgtacaaca tggttccttt cttccctcca gtgactaatg aagaactctt     4200

tttaacctca gaccaacttg gctacagcta tgccatcgat ctgccagttt cagttgaaga     4260

aactccaggt tggcccacaa ctctcttagt agtcatggga acactggtgg ctttggttgg     4320

tctttttgtg ctgttggctt ttcttcaata tagaagactt cgaaaaggat atacacccct     4380

aatggagaca catttaagca gcaagagata cacagaagaa gcctagggtg ctcatgcctt     4440

acctaagaga agaggctggc caagccacag ttctgacgct gacaataaag gaactaatcc     4500

tcactgttcc ttcttgagtt gaagatcttt gacataggtt cttctatagt gatgatgatc     4560

tcattcagaa gatgcttagc tgtagtttcc gctttgcttg cttgtttaac aaacccaact     4620

aaagtgcttg aggctacctc taccttcaaa taaagataga cctgacaatt tgtgatatct     4680

aataataacc ccccccccaa tattgattaa gcctcctcct tttctgaaag catttaaaaa     4740

aaa                                                                   4743


<210>  4
<211>  3911
<212>  DNA
<213>  Homo sapiens

<400>  4
aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata       60

ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg      120

acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc      180

ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca      240

tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa      300

ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga      360

taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta      420

taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct      480

gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa      540

ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg      600

ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg      660

aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac      720

aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg      780

cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag      840

agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat      900

caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa      960

ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt     1020

aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac     1080

ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga     1140

gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac     1200

agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag     1260

attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt     1320

gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa     1380

attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc     1440

cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga     1500

tgggactcaa ctgagttcaa ggcaattaaa gtcaagagct aaggagggag ggagagggtt     1560

tagaaatacc agcataataa gtagtatgac tgggtgctct gtaaattaac tcaattagac     1620

aaagcctgac ttaacggggg aagatggtga gaagcgctac cctcattaaa tttggttgtt     1680

agaggcgctt ctaaggaaat taagtctgtt agttgtttga atcacataaa attgtgtgtg     1740

cacgttcatg tacacatgtg cacacatgta acctctgtga ttcttgtggg tattttttta     1800

agaagaaagg aatagaaagc aaagaaaaat aaaaaatact gaaaagaaaa gactgaaaga     1860

gtagaagata aggagaaaag tacgacagag acaaggaaag taagagagag agagagctct     1920

cccaattata aagccatgag ccccctttgg tgggggtttc tgctcagttg cttgggctgc     1980

aaaatcctgc caggagccca gggtcagttc ccccgagtct gcatgacggt ggacagccta     2040

gtgaacaagg agtgctgccc acgcctgggt gcagagtcgg ccaatgtctg tggctctcag     2100

caaggccggg ggcagtgcac agaggtgcga gccgacacaa ggccctggag tggtccctac     2160

atcctacgaa accaggatga ccgtgagctg tggccaagaa aattcttcca ccggacctgc     2220

aagtgcacag gaaactttgc cggctataat tgtggagact gcaagtttgg ctggaccggt     2280

cccaactgcg agcggaagaa accaccagtg attcggcaga acatccattc cttgagtcct     2340

caggaaagag agcagttctt gggcgcctta gatctcgcga agaagagagt acaccccgac     2400

tacgtgatca ccacacaaca ctggctgggc ctgcttgggc ccaatggaac ccagccgcag     2460

tttgccaact gcagtgttta tgattttttt gtgtggctcc attattattc tgttagagat     2520

acattattag gaccaggacg cccctacagg gccatagatt tctcacatca aggacctgca     2580

tttgttacct ggcaccggta ccatttgttg tgtctggaaa gagatctcca gcgactcatt     2640

ggcaatgagt cttttgcttt gccctactgg aactttgcca ctgggaggaa cgagtgtgat     2700

gtgtgtacag accagctgtt tggggcagcg agaccagacg atccgactct gattagtcgg     2760

aactcaagat tctccagctg ggaaactgtc tgtgatagct tggatgacta caaccacctg     2820

gtcaccttgt gcaatggaac ctatgaaggt ttgctgagaa gaaatcaaat gggaagaaac     2880

agcatgaaat tgccaacctt aaaagacata cgagattgcc tgtctctcca gaagtttgac     2940

aatcctccct tcttccagaa ctctaccttc agtttcagga atgctttgga agggtttgat     3000

aaagcagatg ggactctgga ttctcaagtg atgagccttc ataatttggt tcattccttc     3060

ctgaacggga caaacgcttt gccacattca gccgccaatg atcccatttt tgtggtgatt     3120

tctaatcgtt tgctttacaa tgctacaaca aacatccttg aacatgtaag aaaagagaaa     3180

gcgaccaagg aactcccttc cctgcatgtg ctggttcttc attcctttac tgatgccatc     3240

tttgatgagt ggatgaaaag atttaatcct cctgcagatg cctggcctca ggagctggcc     3300

cctattggtc acaatcggat gtacaacatg gttcctttct tccctccagt gactaatgaa     3360

gaactctttt taacctcaga ccaacttggc tacagctatg ccatcgatct gccagtttca     3420

gttgaagaaa ctccaggttg gcccacaact ctcttagtag tcatgggaac actggtggct     3480

ttggttggtc tttttgtgct gttggctttt cttcaatata gaagacttcg aaaaggatat     3540

acacccctaa tggagacaca tttaagcagc aagagataca cagaagaagc ctagggtgct     3600

catgccttac ctaagagaag aggctggcca agccacagtt ctgacgctga caataaagga     3660

actaatcctc actgttcctt cttgagttga agatctttga cataggttct tctatagtga     3720

tgatgatctc attcagaaga tgcttagctg tagtttccgc tttgcttgct tgtttaacaa     3780

acccaactaa agtgcttgag gctacctcta ccttcaaata aagatagacc tgacaatttg     3840

tgatatctaa taataacccc ccccccaata ttgattaagc ctcctccttt tctgaaagca     3900

tttaaaaaaa a                                                          3911


<210>  5
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  5
atgagccccc tttggtgggg gtttctgctc agttgcttgg gctgcaaaat cctgccagga       60

gcccagggtc agttcccccg agtctgcatg acggtggaca gcctagtgaa caaggagtgc      120

tgcccacgcc tgggtgcaga gtcggccaat gtctgtggct ctcagcaagg ccgggggcag      180

tgcacagagg tgcgagccga cacaaggccc tggagtggtc cctacatcct acgaaaccag      240

gatgaccgtg agctgtggcc aagaaaattc ttccaccgga cctgcaagtg cacaggaaac      300

tttgccggct ataattgtgg agactgcaag tttggctgga ccggtcccaa ctgcgagcgg      360

aagaaaccac cagtgattcg gcagaacatc cattccttga gtcctcagga aagagagcag      420

ttcttgggcg ccttagatct cgcgaagaag agagtacacc ccgactacgt gatcaccaca      480

caacactggc tgggcctgct tgggcccaat ggaacccagc cgcagtttgc caactgcagt      540

gtttatgatt tttttgtgtg gctccattat tattctgtta gagatacatt attaggacca      600

ggacgcccct acagggccat agatttctca catcaaggac ctgcatttgt tacctggcac      660

cggtaccatt tgttgtgtct ggaaagagat ctccagcgac tcattggcaa tgagtctttt      720

gctttgccct actggaactt tgccactggg aggaacgagt gtgatgtgtg tacagaccag      780

ctgtttgggg cagcgagacc agacgatccg actctgatta gtcggaactc aagattctcc      840

agctgggaaa ctgtctgtga tagcttggat gactacaacc acctggtcac cttgtgcaat      900

ggaacctatg aaggtttgct gagaagaaat caaatgggaa gaaacagcat gaaattgcca      960

accttaaaag acatacgaga ttgcctgtct ctccagaagt ttgacaatcc tcccttcttc     1020

cagaactcta ccttcagttt caggaatgct ttggaagggt ttgataaagc agatgggact     1080

ctggattctc aagtgatgag ccttcataat ttggttcatt ccttcctgaa cgggacaaac     1140

gctttgccac attcagccgc caatgatccc atttttgtgg ttcttcattc ctttactgat     1200

gccatctttg atgagtggat gaaaagattt aatcctcctg cagatgcctg gcctcaggag     1260

ctggccccta ttggtcacaa tcggatgtac aacatggttc ctttcttccc tccagtgact     1320

aatgaagaac tctttttaac ctcagaccaa cttggctaca gctatgccat cgatctgcca     1380

gtttcagttg aagaaactcc aggttggccc acaactctct tagtagtcat gggaacactg     1440

gtggctttgg ttggtctttt tgtgctgttg gcttttcttc aatatagaag acttcgaaaa     1500

ggatatacac ccctaatgga gacacattta agcagcaaga gatacacaga agaagcctag     1560


<210>  6
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Leu His Ser Phe Thr Asp 
385                 390                 395                 400 


Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp Ala 
                405                 410                 415     


Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn Met 
            420                 425                 430         


Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr Ser 
        435                 440                 445             


Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val Glu 
    450                 455                 460                 


Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr Leu 
465                 470                 475                 480 


Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr Arg 
                485                 490                 495     


Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser Ser 
            500                 505                 510         


Lys Arg Tyr Thr Glu Glu Ala 
        515                 


<210>  7
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  human TRP-2 EcoR5 forward primer

<400>  7
gagccccctt tggtgggggt ttctgctcag ttgcttgg                               38


<210>  8
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  human TRP-2 Xba/PacI reverse primer

<400>  8
ggatggctct agattaatta attactaggc ttcttctgtg tatc                        44


