                         SEQUENCE LISTING

<110>  Humagene Inc.
 
<120>  Novel post-translational fibrinogen variants

<130>  18223PCT00

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Gly Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His 
1               5                   10                  15      


Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala 
            20                  25                  30          


Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala 
        35                  40                  45              


Ala Ala Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly 
    50                  55                  60                  


Cys Leu His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys 
65                  70                  75                  80  


Gln Leu Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser 
                85                  90                  95      


Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser 
            100                 105                 110         


Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg 
        115                 120                 125             


Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser 
    130                 135                 140                 


Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn 
145                 150                 155                 160 


Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg 
                165                 170                 175     


Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr 
            180                 185                 190         


Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly 
        195                 200                 205             


Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met 
    210                 215                 220                 


Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys 
225                 230                 235                 240 


Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln 
                245                 250                 255     


Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly 
            260                 265                 270         


Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu 
        275                 280                 285             


Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg 
    290                 295                 300                 


Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp 
305                 310                 315                 320 


Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn 
                325                 330                 335     


Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala 
            340                 345                 350         


Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr 
        355                 360                 365             


Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly 
    370                 375                 380                 


Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly 
385                 390                 395                 400 


Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr 
                405                 410                 415     


Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp 
            420                 425                 430         


Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg 
        435                 440                 445             


Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
    450                 455                 460     


<210>  2
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Gly Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His 
1               5                   10                  15      


Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala 
            20                  25                  30          


Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala 
        35                  40                  45              


Ala Ala Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly 
    50                  55                  60                  


Cys Leu His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys 
65                  70                  75                  80  


Gln Leu Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser 
                85                  90                  95      


Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser 
            100                 105                 110         


Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg 
        115                 120                 125             


Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser 
    130                 135                 140                 


Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn 
145                 150                 155                 160 


Ile Ala Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg 
                165                 170                 175     


Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr 
            180                 185                 190         


Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly 
        195                 200                 205             


Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met 
    210                 215                 220                 


Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys 
225                 230                 235                 240 


Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln 
                245                 250                 255     


Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly 
            260                 265                 270         


Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu 
        275                 280                 285             


Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg 
    290                 295                 300                 


Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp 
305                 310                 315                 320 


Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn 
                325                 330                 335     


Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala 
            340                 345                 350         


Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr 
        355                 360                 365             


Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly 
    370                 375                 380                 


Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly 
385                 390                 395                 400 


Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr 
                405                 410                 415     


Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp 
            420                 425                 430         


Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg 
        435                 440                 445             


Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
    450                 455                 460     


<210>  3
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  3
gtgaatagca atatcc                                                       16


<210>  4
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  4
gtgaataggc aatatcg                                                      17


