                                SEQUENCE LISTING

<110> Isis Pharmaceuticals, Inc.
      Cold Springs Harbor Laboratory
      Adrian R. Krainer
      Yimin Hua
      Brenda F. Baker
      Susan M. Freier
      C. Frank Bennett

<120> COMPOSITIONS AND METHODS FOR MODULATION
      OF SMN2 SPLICING

<130> CORE0084WO

<160> 138

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 174
<212> DNA
<213> Homo sapiens

<400> 1
atatatagct atctatatct atatagctat tttttttaac ttcctttatt ttccttacag 60
ggttttagac aaaatcaaaa agaaggaagg tgctcacatt ccttaaatta aggagtaagt 120
ctgccagcat tatgaaagtg aatcttactt ttgtaaaact ttatggtttg tgga       174

<210> 2
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 2
tagatagcta tatat                                                  15

<210> 3
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 3
atagatagct atata                                                  15

<210> 4
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 4
tatagatagc tatat                                                  15

<210> 5
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 5
atatagatag ctata                                                  15

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 6
gatatagata gctat                                                  15

<210> 7
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 7
atagatagct at                                                     12

<210> 8
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 8
agatatagat agcta                                                  15

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 9
tatagatagc ta                                                     12

<210> 10
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 10
tagatataga tagct                                                  15

<210> 11
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 11
atatagatag ct                                                     12

<210> 12
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 12
atagatatag atagc                                                  15

<210> 13
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 13
gatatagata gc                                                     12

<210> 14
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 14
tatagatata gatag                                                  15

<210> 15
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 15
agatatagat ag                                                     12

<210> 16
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 16
atatagatat agata                                                  15

<210> 17
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 17
tagatataga ta                                                     12

<210> 18
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 18
tatatagata tagat                                                  15

<210> 19
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 19
atagatatag at                                                     12

<210> 20
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 20
tatagatata ga                                                     12

<210> 21
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 21
atatagatat ag                                                     12

<210> 22
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 22
atagctatat agata                                                  15

<210> 23
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 23
aaaaaatagc tatat                                                  15

<210> 24
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 24
gttaaaaaaa atagc                                                  15

<210> 25
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 25
aggaagttaa aaaaa                                                  15

<210> 26
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 26
aataaaggaa gttaa                                                  15

<210> 27
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 27
aggaaaataa aggaa                                                  15

<210> 28
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 28
ctgtaaggaa aataa                                                  15

<210> 29
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 29
attttgtcta aaacc                                                  15

<210> 30
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 30
gattttgtct aaaac                                                  15

<210> 31
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 31
ttttgtctaa aa                                                     12

<210> 32
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 32
tgattttgtc taaaa                                                  15

<210> 33
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 33
attttgtcta aa                                                     12

<210> 34
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 34
ttgattttgt ctaaa                                                  15

<210> 35
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 35
gattttgtct aa                                                     12

<210> 36
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 36
tttgattttg tctaa                                                  15

<210> 37
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 37
ttttgatttt gtctaa                                                 16

<210> 38
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 38
ttttgatttt gtcta                                                  15

<210> 39
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 39
tgattttgtc ta                                                     12

<210> 40
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 40
ttgattttgt ct                                                     12

<210> 41
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 41
tttttgattt tgtct                                                  15

<210> 42
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 42
tttgattttg tc                                                     12

<210> 43
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 43
ctttttgatt ttgtc                                                  15

<210> 44
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 44
ttttgatttt gt                                                     12

<210> 45
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 45
tttttgattt tg                                                     12

<210> 46
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 46
cttctttttg atttt                                                  15

<210> 47
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 47
ctttttgatt tt                                                     12

<210> 48
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 48
tctttttgat tt                                                     12

<210> 49
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 49
ccttccttct ttttg                                                  15

<210> 50
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 50
gagcaccttc cttct                                                  15

<210> 51
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 51
aatgtgagca ccttc                                                  15

<210> 52
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 52
taaggaatgt gagca                                                  15

<210> 53
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 53
aatttaagga atgtgagc                                               18

<210> 54
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 54
ttaaggaatg tgagc                                                  15

<210> 55
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 55
taatttaagg aatgtgag                                               18

<210> 56
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 56
tttaaggaat gtgag                                                  15

<210> 57
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 57
aaggaatgtg ag                                                     12

<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 58
ttaatttaag gaatgtga                                               18

<210> 59
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 59
atttaaggaa tgtga                                                  15

<210> 60
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 60
taaggaatgt ga                                                     12

<210> 61
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 61
cttaatttaa ggaatgtg                                               18

<210> 62
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 62
aatttaagga atgtg                                                  15

<210> 63
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 63
ttaaggaatg tg                                                     12

<210> 64
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 64
taatttaagg aatgt                                                  15

<210> 65
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 65
ccttaattta aggaatgt                                               18

<210> 66
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 66
tttaaggaat gt                                                     12

<210> 67
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 67
ttaatttaag gaatg                                                  15

<210> 68
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 68
atttaaggaa tg                                                     12

<210> 69
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 69
cttaatttaa ggaat                                                  15

<210> 70
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 70
aatttaagga at                                                     12

<210> 71
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 71
ccttaattta aggaa                                                  15

<210> 72
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 72
taatttaagg aa                                                     12

<210> 73
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 73
tccttaattt aagga                                                  15

<210> 74
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 74
ttaatttaag ga                                                     12

<210> 75
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 75
cttaatttaa gg                                                     12

<210> 76
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 76
ccttaattta ag                                                     12

<210> 77
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 77
tgctggcaga cttac                                                  15

<210> 78
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 78
cataatgctg gcaga                                                  15

<210> 79
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 79
tcataatgct ggcag                                                  15

<210> 80
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 80
ttcataatgc tggca                                                  15

<210> 81
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 81
tttcataatg ctggc                                                  15

<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 82
attcactttc ataatgctgg                                             20

<210> 83
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 83
ctttcataat gctgg                                                  15

<210> 84
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 84
tcataatgct gg                                                     12

<210> 85
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 85
actttcataa tgctg                                                  15

<210> 86
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 86
ttcataatgc tg                                                     12

<210> 87
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 87
cactttcata atgct                                                  15

<210> 88
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 88
tttcataatg ct                                                     12

<210> 89
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 89
tcactttcat aatgc                                                  15

<210> 90
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 90
ctttcataat gc                                                     12

<210> 91
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 91
ttcactttca taatg                                                  15

<210> 92
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 92
actttcataa tg                                                     12

<210> 93
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 93
attcactttc ataat                                                  15

<210> 94
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 94
cactttcata at                                                     12

<210> 95
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 95
gattcacttt cataa                                                  15

<210> 96
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 96
tcactttcat aa                                                     12

<210> 97
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 97
ttcactttca ta                                                     12

<210> 98
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 98
attcactttc at                                                     12

<210> 99
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 99
agtaagattc acttt                                                  15

<210> 100
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 100
acaaaagtaa gattc                                                  15

<210> 101
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 101
gttttacaaa agtaa                                                  15

<210> 102
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 102
ataaagtttt acaaa                                                  15

<210> 103
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 103
aaaccataaa gtttt                                                  15

<210> 104
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 104
tccacaaacc ataaa                                                  15

<210> 105
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> Consensus splice site
      

<400> 105
gtaagtactt                                                        10

<210> 106
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 106
agataaaagg ttaatctaga tccctactag aattctc                          37

<210> 107
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 107
gagaattcta gtagggatct agattaacct tttatct                          37

<210> 108
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 108
aattgctaac gcagtcagtg cttc                                        24

<210> 109
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 109
aatatgatca gcaaaacaaa gtcacataac tac                              33

<210> 110
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 110
gtgactttgt tttgctgatc atattttgtt gaataaaata ag                    42

<210> 111
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 111
aatgtatctt atcatgtctg ctcg                                        24

<210> 112
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 112
aatgtatctt atcatgtctg ctcg                                        24

<210> 113
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 113
aagtacttac ctgtaacgct tcacattcca gatctgtc                         38

<210> 114
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 114
ttgtattcta tgttt                                                  15

<210> 115
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 115
actttcataa tgctggca 						   18

<210> 116
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 116
cactttcata atgctggc                                               18

<210> 117	
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 117
tcactttcat aatgctgg                                               18

<210> 118	
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 118
ttcactttca taatgctg                                               18

<210> 119	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 119
tttcataatg ctggc                                                  15

<210> 120	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 120
attcactttc ataat                                                  15

<210> 121	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 121
ttcactttca taatg                                                  15

<210> 122	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 122
tcactttcat aatgc                                                  15

<210> 123	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 123
cactttcata atgct                                                  15

<210> 124	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 124
ctttcataat gctgg                                                  15

<210> 125	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 125
tttcataatg ctggc                                                  15

<210> 126	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 126
ttcataatgc tggca                                                  15

<210> 127	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 127
tcataatgct ggcag                                                  15

<210> 128	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 128
attcactttc at                                                  12

<210> 129	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 129
ttcactttca ta                                                  12

<210> 130	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 130
tcactttcat aa                                                  12

<210> 131	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 131
cactttcata at                                                  12

<210> 132	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 132
actttcataa tg                                                  12

<210> 133	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 133
ctttcataat gc                                                  12

<210> 134	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 134
tttcataatg ct                                                  12

<210> 135	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 135
ttcataatgc tg                                                  12

<210> 136	
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 136
tcataatgct gg                                                  12

<210> 137	
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 137
tgcatctcat tgtag                                                15


<210> 138
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense Compound

<400> 138
ttagtttaat cacgctcg                                             18







                
