                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum

 
<120>  Use of MLKL in cancer therapy

<130>  DK66232PC

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag       60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag      120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca      180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc      240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac      300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa      360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat      420

gcagacgaag acaggcgagc tttccagatg ctaagaagag ataatgaaaa aatagaagct      480

tcactgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtattta      540

ccaccaaaat gcatgcagga gatcccgcaa gagcaaatca aggagatcaa gaaggagcag      600

ctttcaggat ccccgtggat tctgctaagg gaaaatgaag tcagcacact ttataaagga      660

gaataccaca gagctccagt ggccataaaa gtattcaaaa aactccaggc tggcagcatt      720

gcaatagtga ggcagacttt caataaggag atcaaaacca tgaagaaatt cgaatctccc      780

aacatcctgc gtatatttgg gatttgcatt gatgaaacag tgactccgcc tcaattctcc      840

attgtcatgg agtactgtga actcgggacc ctgagggagc tgttggatag ggaaaaagac      900

ctcacacttg gcaagcgcat ggtcctagtc ctgggggcag cccgaggcct ataccggcta      960

caccattcag aagcacctga actccacgga aaaatcagaa gctcaaactt cctggtaact     1020

caaggctacc aagtgaagct tgcaggattt gagttgagga aaacacagac ttccatgagt     1080

ttgggaacta cgagagaaaa gacagacaga gtcaaatcta cagcatatct ctcacctcag     1140

gaactggaag atgtatttta tcaatatgat gtaaagtctg aaatatacag ctttggaatc     1200

gtcctctggg aaatcgccac tggagatatc ccgtttcaag gctgtaattc tgagaagatc     1260

cgcaagctgg tggctgtgaa gcggcagcag gagccactgg gtgaagactg cccttcagag     1320

ctgcgggaga tcattgatga gtgccgggcc catgatccct ctgtgcggcc ctctgtggat     1380

gaaatcttaa agaaactctc caccttttct aagtag                               1416


<210>  2
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys 
465                 470     


<210>  3
<211>  1416
<212>  DNA
<213>  artificial

<220>
<223>  MLKL-mutein, K230A

<400>  3
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag       60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag      120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca      180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc      240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac      300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa      360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat      420

gcagacgaag acaggcgagc tttccagatg ctaagaagag ataatgaaaa aatagaagct      480

tcactgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtattta      540

ccaccaaaat gcatgcagga gatcccgcaa gagcaaatca aggagatcaa gaaggagcag      600

ctttcaggat ccccgtggat tctgctaagg gaaaatgaag tcagcacact ttataaagga      660

gaataccaca gagctccagt ggccatagca gtattcaaaa aactccaggc tggcagcatt      720

gcaatagtga ggcagacttt caataaggag atcaaaacca tgaagaaatt cgaatctccc      780

aacatcctgc gtatatttgg gatttgcatt gatgaaacag tgactccgcc tcaattctcc      840

attgtcatgg agtactgtga actcgggacc ctgagggagc tgttggatag ggaaaaagac      900

ctcacacttg gcaagcgcat ggtcctagtc ctgggggcag cccgaggcct ataccggcta      960

caccattcag aagcacctga actccacgga aaaatcagaa gctcaaactt cctggtaact     1020

caaggctacc aagtgaagct tgcaggattt gagttgagga aaacacagac ttccatgagt     1080

ttgggaacta cgagagaaaa gacagacaga gtcaaatcta cagcatatct ctcacctcag     1140

gaactggaag atgtatttta tcaatatgat gtaaagtctg aaatatacag ctttggaatc     1200

gtcctctggg aaatcgccac tggagatatc ccgtttcaag gctgtaattc tgagaagatc     1260

cgcaagctgg tggctgtgaa gcggcagcag gagccactgg gtgaagactg cccttcagag     1320

ctgcgggaga tcattgatga gtgccgggcc catgatccct ctgtgcggcc ctctgtggat     1380

gaaatcttaa agaaactctc caccttttct aagtag                               1416


<210>  4
<211>  471
<212>  PRT
<213>  artificial

<220>
<223>  MLKL-mutein, K230A

<400>  4

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Ala Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys 
465                 470     


<210>  5
<211>  1416
<212>  DNA
<213>  artificial

<220>
<223>  MLKL-mutein, K331A

<400>  5
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag       60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag      120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca      180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc      240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac      300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa      360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat      420

gcagacgaag acaggcgagc tttccagatg ctaagaagag ataatgaaaa aatagaagct      480

tcactgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtattta      540

ccaccaaaat gcatgcagga gatcccgcaa gagcaaatca aggagatcaa gaaggagcag      600

ctttcaggat ccccgtggat tctgctaagg gaaaatgaag tcagcacact ttataaagga      660

gaataccaca gagctccagt ggccataaaa gtattcaaaa aactccaggc tggcagcatt      720

gcaatagtga ggcagacttt caataaggag atcaaaacca tgaagaaatt cgaatctccc      780

aacatcctgc gtatatttgg gatttgcatt gatgaaacag tgactccgcc tcaattctcc      840

attgtcatgg agtactgtga actcgggacc ctgagggagc tgttggatag ggaaaaagac      900

ctcacacttg gcaagcgcat ggtcctagtc ctgggggcag cccgaggcct ataccggcta      960

caccattcag aagcacctga actccacgga gcaatcagaa gctcaaactt cctggtaact     1020

caaggctacc aagtgaagct tgcaggattt gagttgagga aaacacagac ttccatgagt     1080

ttgggaacta cgagagaaaa gacagacaga gtcaaatcta cagcatatct ctcacctcag     1140

gaactggaag atgtatttta tcaatatgat gtaaagtctg aaatatacag ctttggaatc     1200

gtcctctggg aaatcgccac tggagatatc ccgtttcaag gctgtaattc tgagaagatc     1260

cgcaagctgg tggctgtgaa gcggcagcag gagccactgg gtgaagactg cccttcagag     1320

ctgcgggaga tcattgatga gtgccgggcc catgatccct ctgtgcggcc ctctgtggat     1380

gaaatcttaa agaaactctc caccttttct aagtag                               1416


<210>  6
<211>  471
<212>  PRT
<213>  artificial

<220>
<223>  MLKL-mutein, K331A

<400>  6

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Ala Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys 
465                 470     


<210>  7
<211>  1395
<212>  DNA
<213>  Mus musculus

<400>  7
atggataaat tgggacagat catcaagtta ggccagctca tctatgaaca gtgtgaaaag       60

atgaaatact gccggaaaca atgccagcgt ctaggaaacc gtgtgcacgg cctgctacag      120

cctctccaga gactccaggc ccaaggaaag aagaacctgc ccgatgacat tactgctgcc      180

ctgggccgtt ttgatgaagt cctgaaggag gctaaccagc agatagaaaa gttcagcaag      240

aagtcccata tttggaagtt tgtgagtgtg ggcaatgata agatcctctt ccatgaagtg      300

aatgagaagc tgagagacgt ctgggaggag ctgttgctgc tgcttcaggt ttatcattgg      360

aataccgttt cagatgtcag ccagccagca tcctggcagc aggaagatcg acaggatgca      420

gaggaagacg gaaatgaaaa tatgaaagtt atcctgatgc agttgcaaat tagcgtggaa      480

gaaatcaaca aaaccctgaa gcaatgctca ctaaaaccca cacaggagat cccacaagat      540

ctccaaatca aggagattcc aaaggaacat cttggacctc cgtggaccaa actgaagaca      600

agtaaaatga gcaccattta tagaggagag tatcacagat ctccagttac catcaaagta      660

ttcaacaacc cccaggccga aagtgttgga atagtgaggt tcactttcaa tgacgagatc      720

aaaaccatga agaaattcga ttctcccaac atcttgcgta tatttgggat ttgcattgat      780

caaacagtga agccccctga gttctccatt gtcatggagt actgtgaact tggaaccctg      840

agggaactgc tggatagaga aaaagacctc acaatgagtg tgcgcagcct cctagtcctg      900

agggcagcca gaggcttata caggctacac cattcggaaa cactccacag aaacatcagc      960

agctccagtt tcctcgtagc cggaggctac caagtaaagc ttgcaggatt tgagttaagc     1020

aaaacacaga attccatcag ccggacagca aagagcacta aagcagagag atccagttca     1080

acgatatatg tctcccctga gagactgaaa aatccatttt gcctttatga cataaaagct     1140

gaaatatata gctttggaat tgtactctgg gaaattgcca ctggaaagat cccatttgaa     1200

ggctgtgatt ctaagaagat ccgggagctg gtggctgagg acaagaagca ggaaccagtg     1260

ggtcaggatt gccctgagtt gttgcgggaa atcattaatg agtgtcgtgc ccatgagccc     1320

tcccaacggc cctctgtgga cggaatcttg gagagactgt ctgcggttga agaatccacg     1380

gacaagaagg tgtaa                                                      1395


<210>  8
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  8

Met Asp Lys Leu Gly Gln Ile Ile Lys Leu Gly Gln Leu Ile Tyr Glu 
1               5                   10                  15      


Gln Cys Glu Lys Met Lys Tyr Cys Arg Lys Gln Cys Gln Arg Leu Gly 
            20                  25                  30          


Asn Arg Val His Gly Leu Leu Gln Pro Leu Gln Arg Leu Gln Ala Gln 
        35                  40                  45              


Gly Lys Lys Asn Leu Pro Asp Asp Ile Thr Ala Ala Leu Gly Arg Phe 
    50                  55                  60                  


Asp Glu Val Leu Lys Glu Ala Asn Gln Gln Ile Glu Lys Phe Ser Lys 
65                  70                  75                  80  


Lys Ser His Ile Trp Lys Phe Val Ser Val Gly Asn Asp Lys Ile Leu 
                85                  90                  95      


Phe His Glu Val Asn Glu Lys Leu Arg Asp Val Trp Glu Glu Leu Leu 
            100                 105                 110         


Leu Leu Leu Gln Val Tyr His Trp Asn Thr Val Ser Asp Val Ser Gln 
        115                 120                 125             


Pro Ala Ser Trp Gln Gln Glu Asp Arg Gln Asp Ala Glu Glu Asp Gly 
    130                 135                 140                 


Asn Glu Asn Met Lys Val Ile Leu Met Gln Leu Gln Ile Ser Val Glu 
145                 150                 155                 160 


Glu Ile Asn Lys Thr Leu Lys Gln Cys Ser Leu Lys Pro Thr Gln Glu 
                165                 170                 175     


Ile Pro Gln Asp Leu Gln Ile Lys Glu Ile Pro Lys Glu His Leu Gly 
            180                 185                 190         


Pro Pro Trp Thr Lys Leu Lys Thr Ser Lys Met Ser Thr Ile Tyr Arg 
        195                 200                 205             


Gly Glu Tyr His Arg Ser Pro Val Thr Ile Lys Val Phe Asn Asn Pro 
    210                 215                 220                 


Gln Ala Glu Ser Val Gly Ile Val Arg Phe Thr Phe Asn Asp Glu Ile 
225                 230                 235                 240 


Lys Thr Met Lys Lys Phe Asp Ser Pro Asn Ile Leu Arg Ile Phe Gly 
                245                 250                 255     


Ile Cys Ile Asp Gln Thr Val Lys Pro Pro Glu Phe Ser Ile Val Met 
            260                 265                 270         


Glu Tyr Cys Glu Leu Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys 
        275                 280                 285             


Asp Leu Thr Met Ser Val Arg Ser Leu Leu Val Leu Arg Ala Ala Arg 
    290                 295                 300                 


Gly Leu Tyr Arg Leu His His Ser Glu Thr Leu His Arg Asn Ile Ser 
305                 310                 315                 320 


Ser Ser Ser Phe Leu Val Ala Gly Gly Tyr Gln Val Lys Leu Ala Gly 
                325                 330                 335     


Phe Glu Leu Ser Lys Thr Gln Asn Ser Ile Ser Arg Thr Ala Lys Ser 
            340                 345                 350         


Thr Lys Ala Glu Arg Ser Ser Ser Thr Ile Tyr Val Ser Pro Glu Arg 
        355                 360                 365             


Leu Lys Asn Pro Phe Cys Leu Tyr Asp Ile Lys Ala Glu Ile Tyr Ser 
    370                 375                 380                 


Phe Gly Ile Val Leu Trp Glu Ile Ala Thr Gly Lys Ile Pro Phe Glu 
385                 390                 395                 400 


Gly Cys Asp Ser Lys Lys Ile Arg Glu Leu Val Ala Glu Asp Lys Lys 
                405                 410                 415     


Gln Glu Pro Val Gly Gln Asp Cys Pro Glu Leu Leu Arg Glu Ile Ile 
            420                 425                 430         


Asn Glu Cys Arg Ala His Glu Pro Ser Gln Arg Pro Ser Val Asp Gly 
        435                 440                 445             


Ile Leu Glu Arg Leu Ser Ala Val Glu Glu Ser Thr Asp Lys Lys Val 
    450                 455                 460                 


<210>  9
<211>  1386
<212>  DNA
<213>  Rattus norvegicus

<400>  9
atggataaat tgggacagat catcaagtta ggccagctca tctatgacca gtgtgaaaag       60

atgaaatact gcaaaagaca gtgccggcgt ctaagaaacc gtgtgcatgg cctgctacag      120

cctctccaga ggctccaggc ccaagaaaag aagagcctcc ccagtgacat tactgctgcc      180

ctgggccgtt ttgaggacgt cctaaaagaa gctagacagc agatagaaaa gttcagtcag      240

aagtccaata tttggaagtt tgctactgtg ggcagtgata agatcctctt ccatgaagtg      300

aatgagaagc tgagagacat ctgggaggag ctcttgctgc tgcttcaggt tgatcaatgg      360

aagtctgatt ccgaggtcag ccaaccagca tcctggcagc aggaagatca acaggacgca      420

gaggaagatg gaaatgaaaa tatgaaagtt attttggtga agctgcaaat cagcatggaa      480

gaaatcaaag aggccctgaa gcaatgctca ctaaaaccca tgcaggaggt cccacaagat      540

ttccaagtca aggagattcc gaaggaagat cttggatatc cgtggaccaa actgaagaca      600

aataaactga gcacgattta tagaggagag tattacaaat ctccagtcac catcaaagta      660

ttcaacaacc ccaaggccga aagtgttgga atagtgaggc tcactttcaa tgaggagatc      720

aaaaccatga agaaatttga ttctcccaac atcctgcgta tatttgggat ttgcatcgat      780

caaacagtga agccccccga attctccatt gtcatggagt actgtgaact cggaaccctg      840

agggaactgc tggatagaga caaggacctc accatgagtg tgcgcagcct cctagtcctg      900

agggcagcta gaggcttgta caggttacac cactcgggaa cactccacgg aaacatcagc      960

agctccagct tcctggtagc tggaggctac caagtaaagc ttgcaggatt tgagctaagc     1020

aaaacacaga cttctataag ccgggcaaca aagagcacta aagcagagag attcagttcg     1080

acagcatatg tctcccccga gagactgcaa gatccatttt gcaaatatga cacaaaagct     1140

gaaatatata gctttggaat tgtgctctgg gaaattgcca ctggaaagat cccgtttgaa     1200

ggctgtgatt ctgagaagat ctatgagctg gtggctgaga acaagaagca ggagccagtg     1260

ggtcaggatt gccccgagtt gttgcaggag atcattaatg agtgccgggc ccatgaaccc     1320

tccaatcggc cctctgcgga tggtaggatt ctttctgtca aagagtgcaa gctgtgtgtt     1380

ttgtga                                                                1386


<210>  10
<211>  461
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Asp Lys Leu Gly Gln Ile Ile Lys Leu Gly Gln Leu Ile Tyr Asp 
1               5                   10                  15      


Gln Cys Glu Lys Met Lys Tyr Cys Lys Arg Gln Cys Arg Arg Leu Arg 
            20                  25                  30          


Asn Arg Val His Gly Leu Leu Gln Pro Leu Gln Arg Leu Gln Ala Gln 
        35                  40                  45              


Glu Lys Lys Ser Leu Pro Ser Asp Ile Thr Ala Ala Leu Gly Arg Phe 
    50                  55                  60                  


Glu Asp Val Leu Lys Glu Ala Arg Gln Gln Ile Glu Lys Phe Ser Gln 
65                  70                  75                  80  


Lys Ser Asn Ile Trp Lys Phe Ala Thr Val Gly Ser Asp Lys Ile Leu 
                85                  90                  95      


Phe His Glu Val Asn Glu Lys Leu Arg Asp Ile Trp Glu Glu Leu Leu 
            100                 105                 110         


Leu Leu Leu Gln Val Asp Gln Trp Lys Ser Asp Ser Glu Val Ser Gln 
        115                 120                 125             


Pro Ala Ser Trp Gln Gln Glu Asp Gln Gln Asp Ala Glu Glu Asp Gly 
    130                 135                 140                 


Asn Glu Asn Met Lys Val Ile Leu Val Lys Leu Gln Ile Ser Met Glu 
145                 150                 155                 160 


Glu Ile Lys Glu Ala Leu Lys Gln Cys Ser Leu Lys Pro Met Gln Glu 
                165                 170                 175     


Val Pro Gln Asp Phe Gln Val Lys Glu Ile Pro Lys Glu Asp Leu Gly 
            180                 185                 190         


Tyr Pro Trp Thr Lys Leu Lys Thr Asn Lys Leu Ser Thr Ile Tyr Arg 
        195                 200                 205             


Gly Glu Tyr Tyr Lys Ser Pro Val Thr Ile Lys Val Phe Asn Asn Pro 
    210                 215                 220                 


Lys Ala Glu Ser Val Gly Ile Val Arg Leu Thr Phe Asn Glu Glu Ile 
225                 230                 235                 240 


Lys Thr Met Lys Lys Phe Asp Ser Pro Asn Ile Leu Arg Ile Phe Gly 
                245                 250                 255     


Ile Cys Ile Asp Gln Thr Val Lys Pro Pro Glu Phe Ser Ile Val Met 
            260                 265                 270         


Glu Tyr Cys Glu Leu Gly Thr Leu Arg Glu Leu Leu Asp Arg Asp Lys 
        275                 280                 285             


Asp Leu Thr Met Ser Val Arg Ser Leu Leu Val Leu Arg Ala Ala Arg 
    290                 295                 300                 


Gly Leu Tyr Arg Leu His His Ser Gly Thr Leu His Gly Asn Ile Ser 
305                 310                 315                 320 


Ser Ser Ser Phe Leu Val Ala Gly Gly Tyr Gln Val Lys Leu Ala Gly 
                325                 330                 335     


Phe Glu Leu Ser Lys Thr Gln Thr Ser Ile Ser Arg Ala Thr Lys Ser 
            340                 345                 350         


Thr Lys Ala Glu Arg Phe Ser Ser Thr Ala Tyr Val Ser Pro Glu Arg 
        355                 360                 365             


Leu Gln Asp Pro Phe Cys Lys Tyr Asp Thr Lys Ala Glu Ile Tyr Ser 
    370                 375                 380                 


Phe Gly Ile Val Leu Trp Glu Ile Ala Thr Gly Lys Ile Pro Phe Glu 
385                 390                 395                 400 


Gly Cys Asp Ser Glu Lys Ile Tyr Glu Leu Val Ala Glu Asn Lys Lys 
                405                 410                 415     


Gln Glu Pro Val Gly Gln Asp Cys Pro Glu Leu Leu Gln Glu Ile Ile 
            420                 425                 430         


Asn Glu Cys Arg Ala His Glu Pro Ser Asn Arg Pro Ser Ala Asp Gly 
        435                 440                 445             


Arg Ile Leu Ser Val Lys Glu Cys Lys Leu Cys Val Leu 
    450                 455                 460     


<210>  11
<211>  1416
<212>  DNA
<213>  Pan troglodytes

<400>  11
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag       60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag      120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca      180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc      240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac      300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa      360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat      420

gcagacgaag acaggcgagc cttccagatg ctaagaagag ataatgaaaa aatagaagct      480

tcattgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtattta      540

ccaccaaaat gcatgcagga gatcccgcaa gagcaaatca aggagatcaa gaaggagcag      600

ctttcaggat ccccgtggat tctgctaagg gaaaatgaag tcagcacact ttataaagga      660

gaataccaca gagctccagt ggccataaaa gtattcaaaa aactccaggc tggcagcatt      720

gcaatagtga ggcagacttt caataatgag atcaaaacca tgaagaaatt cgaatctccc      780

aacatcctgc gtatatttgg gatttgcatt gatgaaacag tgactccgcc tcaattctcc      840

gttgtcatgg agtactgtga actcgggacc ctgagggagc tgttggatag ggaaaaagac      900

ctcacacttg gcaagcgcat ggtcctagtc ctgggggcag cccgaggcct gtaccggcta      960

caccattcag aagcacctga actccacgga aaaatcagaa gctcaaactt cctggtaact     1020

caaggctacc aagtgaagct tgcaggattt gagttgaggg aaacacagac ttccatgagt     1080

ttgggaacta cgagagaaaa gacagacaaa gtcaaatcta cagcatatct ctcacctcag     1140

gaactggaag acgtatttta tctatatgat gtaaagtctg aaatatacag ctttggaatc     1200

gtcctctggg aaatcgccac tggagatatc ccgtttcaag gctgtaattc tgaggagatc     1260

cgcaagctgg tgtctgtgga gcgggagcag gagccgctgg gtgaagactg cccttcagag     1320

ctgcgggaga tcattgatca gtgccgggcc catgatccct ctttgcggcc ctccgtggat     1380

gaaatcttaa agaaactctc caccttttct aagtag                               1416


<210>  12
<211>  471
<212>  PRT
<213>  Pan troglodytes

<400>  12

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Asn Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Val Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Glu Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Lys Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Leu Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Glu Ile Arg Lys Leu Val Ser Val Glu Arg Glu Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Gln Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Leu Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys 
465                 470     


<210>  13
<211>  792
<212>  DNA
<213>  Pan troglodytes

<400>  13
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag       60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag      120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca      180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc      240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac      300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa      360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat      420

gcagacgaag acaggcgagc cttccagatg ctaagaagag ataatgaaaa aatagaagct      480

tcattgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtctttg      540

gaatcgtcct ctgggaaatc gccactggag atatcccgtt tcaaggtgaa gaatgtgaag      600

actggctcag ccagtggctg taattctgag gagatccgca agctggtgtc tgtggagcgg      660

gagcaggagc cgctgggtga agactgccct tcagagctgc gggagatcat tgatcagtgc      720

cgggcccatg atccctcttt gcggccctcc gtggatgaaa tcttaaagaa actctccacc      780

ttttctaagt ag                                                          792


<210>  14
<211>  263
<212>  PRT
<213>  Pan troglodytes

<400>  14

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Ser Leu Glu Ser Ser Ser Gly Lys Ser Pro Leu Glu Ile Ser 
            180                 185                 190         


Arg Phe Lys Val Lys Asn Val Lys Thr Gly Ser Ala Ser Gly Cys Asn 
        195                 200                 205             


Ser Glu Glu Ile Arg Lys Leu Val Ser Val Glu Arg Glu Gln Glu Pro 
    210                 215                 220                 


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Gln Cys 
225                 230                 235                 240 


Arg Ala His Asp Pro Ser Leu Arg Pro Ser Val Asp Glu Ile Leu Lys 
                245                 250                 255     


Lys Leu Ser Thr Phe Ser Lys 
            260             


<210>  15
<211>  825
<212>  DNA
<213>  artificial

<220>
<223>  ANKRD7

<400>  15
atgaataagc ttttcagctt ctggaagagg aagaatgaga cccgcagcca gggctacaac       60

cttcgagaaa aggatttaaa gaaacttcac agagctgctt cagtcgggga tttgaagaag      120

ctgaaggaat accttcagat caagaaatat gatgtaaata tgcaggacaa aaaatacagt      180

gttgtccaat cttctagatg gcttttatcc tacaccactc cgctgaatga ctttataaga      240

acacctttgc acctagcctg tgctaatgga catacagatg ttgtactttt cctaattgag      300

caacaatgca aaataaatgt ccgggatagt gaaaacaaat ccccattgat taaggcagta      360

cagtgtcaaa atgaggattg tgctactatt cttctaaact ttggtgcaga cccagatctg      420

agggatattc gttataatac tgttcttcac tatgctgttt gtggtcaaag tttgtcatta      480

gttgaaaaac tgcttgaata cgaagctgat cttgaagcga aaaataagga tgggtatact      540

ccactattag ttgccgttat taacaataat ccaaaaatgg taaaatttct tctggagaaa      600

ggggctgatg tgaatgcttc agataattat caaagaacag cccttattct tgctgtcagt      660

ggtgaaccac catgtttagt aaagcttctt cttcagcaag gtgtggaatt atgttacgaa      720

ggtattgtgg attcacagct gaggaatatg tttatttcca tggttttact gcatagatac      780

ccacaattca ctgcgagcca tggaaagaag aaacatgcta aatag                      825


<210>  16
<211>  274
<212>  PRT
<213>  artificial

<220>
<223>  ANKRD7

<400>  16

Met Asn Lys Leu Phe Ser Phe Trp Lys Arg Lys Asn Glu Thr Arg Ser 
1               5                   10                  15      


Gln Gly Tyr Asn Leu Arg Glu Lys Asp Leu Lys Lys Leu His Arg Ala 
            20                  25                  30          


Ala Ser Val Gly Asp Leu Lys Lys Leu Lys Glu Tyr Leu Gln Ile Lys 
        35                  40                  45              


Lys Tyr Asp Val Asn Met Gln Asp Lys Lys Tyr Ser Val Val Gln Ser 
    50                  55                  60                  


Ser Arg Trp Leu Leu Ser Tyr Thr Thr Pro Leu Asn Asp Phe Ile Arg 
65                  70                  75                  80  


Thr Pro Leu His Leu Ala Cys Ala Asn Gly His Thr Asp Val Val Leu 
                85                  90                  95      


Phe Leu Ile Glu Gln Gln Cys Lys Ile Asn Val Arg Asp Ser Glu Asn 
            100                 105                 110         


Lys Ser Pro Leu Ile Lys Ala Val Gln Cys Gln Asn Glu Asp Cys Ala 
        115                 120                 125             


Thr Ile Leu Leu Asn Phe Gly Ala Asp Pro Asp Leu Arg Asp Ile Arg 
    130                 135                 140                 


Tyr Asn Thr Val Leu His Tyr Ala Val Cys Gly Gln Ser Leu Ser Leu 
145                 150                 155                 160 


Val Glu Lys Leu Leu Glu Tyr Glu Ala Asp Leu Glu Ala Lys Asn Lys 
                165                 170                 175     


Asp Gly Tyr Thr Pro Leu Leu Val Ala Val Ile Asn Asn Asn Pro Lys 
            180                 185                 190         


Met Val Lys Phe Leu Leu Glu Lys Gly Ala Asp Val Asn Ala Ser Asp 
        195                 200                 205             


Asn Tyr Gln Arg Thr Ala Leu Ile Leu Ala Val Ser Gly Glu Pro Pro 
    210                 215                 220                 


Cys Leu Val Lys Leu Leu Leu Gln Gln Gly Val Glu Leu Cys Tyr Glu 
225                 230                 235                 240 


Gly Ile Val Asp Ser Gln Leu Arg Asn Met Phe Ile Ser Met Val Leu 
                245                 250                 255     


Leu His Arg Tyr Pro Gln Phe Thr Ala Ser His Gly Lys Lys Lys His 
            260                 265                 270         


Ala Lys 
        


<210>  17
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaataagc ttttcagctt ctggaagagg aagaatgaga cccgcagcca gggctacaac       60

cttcgagaaa aggatttaaa gaaacttcac agagctgctt cagtcgggga tttgaagaag      120

ctgaaggaat accttcagat caagaaatat gatgtaaata tgcaggacaa aaaatacaga      180

acacctttgc acctagcctg tgctaatgga catacagatg ttgtactttt cctaattgag      240

caacaatgca aaataaatgt ccgggatagt gaaaacaaat ccccattgat taaggcagta      300

cagtgtcaaa atgaggattg tgctactatt cttctaaact ttggtgcaga cccagatctg      360

agggatattc gttataatac tgttcttcac tatgctgttt gtggtcaaag tttgtcatta      420

gttgaaaaac tgcttgaata cgaagctgat cttgaagcga aaaataagga tgggtatact      480

ccactattag ttgccgttat taacaataat ccaaaaatgg taaaatttct tctggagaaa      540

ggggctgatg tgaatgcttc agataattat caaagaacag cccttattct tgctgtcagt      600

ggtgaaccac catgtttagt aaagcttctt cttcagcaag gtgtggaatt atgttacgaa      660

ggtattgtgg attcacagct gaggaatatg tttatttcca tggttttact gcatagatac      720

ccacaattca ctgcgagcca tggaaagaag aaacatgcta aatag                      765


<210>  18
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Lys Leu Phe Ser Phe Trp Lys Arg Lys Asn Glu Thr Arg Ser 
1               5                   10                  15      


Gln Gly Tyr Asn Leu Arg Glu Lys Asp Leu Lys Lys Leu His Arg Ala 
            20                  25                  30          


Ala Ser Val Gly Asp Leu Lys Lys Leu Lys Glu Tyr Leu Gln Ile Lys 
        35                  40                  45              


Lys Tyr Asp Val Asn Met Gln Asp Lys Lys Tyr Arg Thr Pro Leu His 
    50                  55                  60                  


Leu Ala Cys Ala Asn Gly His Thr Asp Val Val Leu Phe Leu Ile Glu 
65                  70                  75                  80  


Gln Gln Cys Lys Ile Asn Val Arg Asp Ser Glu Asn Lys Ser Pro Leu 
                85                  90                  95      


Ile Lys Ala Val Gln Cys Gln Asn Glu Asp Cys Ala Thr Ile Leu Leu 
            100                 105                 110         


Asn Phe Gly Ala Asp Pro Asp Leu Arg Asp Ile Arg Tyr Asn Thr Val 
        115                 120                 125             


Leu His Tyr Ala Val Cys Gly Gln Ser Leu Ser Leu Val Glu Lys Leu 
    130                 135                 140                 


Leu Glu Tyr Glu Ala Asp Leu Glu Ala Lys Asn Lys Asp Gly Tyr Thr 
145                 150                 155                 160 


Pro Leu Leu Val Ala Val Ile Asn Asn Asn Pro Lys Met Val Lys Phe 
                165                 170                 175     


Leu Leu Glu Lys Gly Ala Asp Val Asn Ala Ser Asp Asn Tyr Gln Arg 
            180                 185                 190         


Thr Ala Leu Ile Leu Ala Val Ser Gly Glu Pro Pro Cys Leu Val Lys 
        195                 200                 205             


Leu Leu Leu Gln Gln Gly Val Glu Leu Cys Tyr Glu Gly Ile Val Asp 
    210                 215                 220                 


Ser Gln Leu Arg Asn Met Phe Ile Ser Met Val Leu Leu His Arg Tyr 
225                 230                 235                 240 


Pro Gln Phe Thr Ala Ser His Gly Lys Lys Lys His Ala Lys 
                245                 250                 


<210>  19
<211>  1557
<212>  DNA
<213>  artificial

<220>
<223>  RIPK3-mRNA-sequence (coding sequence)

<400>  19
atgtcgtgcg tcaagttatg gcccagcggt gcccccgccc ccttggtgtc catcgaggaa       60

ctggagaacc aggagctcgt cggcaaaggc gggttcggca cagtgttccg ggcgcaacat      120

aggaagtggg gctacgatgt ggcggtcaag atcgtaaact cgaaggcgat atccagggag      180

gtcaaggcca tggcaagtct ggataacgaa ttcgtgctgc gcctagaagg ggttatcgag      240

aaggtgaact gggaccaaga tcccaagccg gctctggtga ctaaattcat ggagaacggc      300

tccttgtcgg ggctgctgca gtcccagtgc cctcggccct ggccgctcct ttgccgcctg      360

ctgaaagaag tggtgcttgg gatgttttac ctgcacgacc agaacccggt gctcctgcac      420

cgggacctca agccatccaa cgtcctgctg gacccagagc tgcacgtcaa gctggcagat      480

tttggcctgt ccacatttca gggaggctca cagtcaggga cagggtccgg ggagccaggg      540

ggcaccctgg gctacttggc cccagaactg tttgttaacg taaaccggaa ggcctccaca      600

gccagtgacg tctacagctt cgggatccta atgtgggcag tgcttgctgg aagagaagtt      660

gagttgccaa ccgaaccatc actcgtgtac gaagcagtgt gcaacaggca gaaccggcct      720

tcattggctg agctgcccca agccgggcct gagactcccg gcttagaagg actgaaggag      780

ctaatgcagc tctgctggag cagtgagccc aaggacagac cctccttcca ggaatgccta      840

ccaaaaactg atgaagtctt ccagatggtg gagaacaata tgaatgctgc tgtctccacg      900

gtaaaggatt tcctgtctca gctcaggagc agcaatagga gattttctat cccagagtca      960

ggccaaggag ggacagaaat ggatggcttt aggagaacca tagaaaacca gcactctcgt     1020

aatgatgtca tggtttctga gtggctaaac aaactgaatc tagaggagcc tcccagctct     1080

gttcctaaaa aatgcccgag ccttaccaag aggagcaggg cacaagagga gcaggttcca     1140

caagcctgga cagcaggcac atcttcagat tcgatggccc aacctcccca gactccagag     1200

acctcaactt tcagaaacca gatgcccagc cctacctcaa ctggaacacc aagtcctgga     1260

ccccgaggga atcagggggc tgagagacaa ggcatgaact ggtcctgcag gaccccggag     1320

ccaaatccag taacagggcg accgctcgtt aacatataca actgctctgg ggtgcaagtt     1380

ggagacaaca actacttgac tatgcaacag acaactgcct tgcccacatg gggcttggca     1440

ccttcgggca aggggagggg cttgcagcac cccccaccag taggttcgca agaaggccct     1500

aaagatcctg aagcctggag caggccacag ggttggtata atcatagcgg gaaataa        1557


<210>  20
<211>  518
<212>  PRT
<213>  artificial

<220>
<223>  RIPK3 amino acid sequence (coding sequence)

<400>  20

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn 
    450                 455                 460                 


Tyr Leu Thr Met Gln Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala 
465                 470                 475                 480 


Pro Ser Gly Lys Gly Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser 
                485                 490                 495     


Gln Glu Gly Pro Lys Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp 
            500                 505                 510         


Tyr Asn His Ser Gly Lys 
        515             


<210>  21
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer K230A sense

<400>  21
ccacagagct ccagtggcca tagcagtatt caaaaaactc ca                          42


<210>  22
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer K230A_antisense

<400>  22
tggagttttt tgaatactgc tatggccact ggagctctgt gg                          42


<210>  23
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  primer K331A sense

<400>  23
agcacctgaa ctccacggag caatcagaag ctcaaacttc                             40


<210>  24
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  primer K331A_antisense

<400>  24
gaagtttgag cttctgattg ctccgtggag ttcaggtgct                             40


<210>  25
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer MLKL_Exon3

<400>  25
aagcttcact gagacgatta ga                                                22


<210>  26
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer MLKL_Exon9

<400>  26
gatttcccag aggacgattc                                                   20


