
                                SEQUENCE LISTING

<110> Wilkes, David

<120> COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC
      OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA
  

<130> 480266.404PC

<140> PCT
<141> 2010-04-22

<150> US 61/266,048
<151> 2009-12-02

<150> US 61/171,705                  
<151> 2009-04-22  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 8439
<212> DNA
<213> Homo sapiens

<400> 1
cgcactctcc gtccccgcgg ctggcgcagg acctcactcg agcggagcgc ccacggggag 60
cgggtcgcgg ggcggcggcg gcgaggagga ggcgagaagg agttggagga ggaggaggag 120
gaggcgaggg cgagctagcc cagcggggtc ccggccgccc cgcgggccaa agtcgagccc 180
tcccgcccgt gggcgagcgc gccagccgcc ccttccagaa cagccgccgc cacaaagaag 240
aacggggggt gccgaggtcc ccatgacctc ctaaagtggt gcggtccctg ctgagtgcgc 300
tgcccgggcc gtgacccgcg cccctgtgcg tccccgcgcg cctccgagcg cccctgtgcg 360
ccccggcccg cgccccgccg gcatggacgt ccatacccgc tggaaagcgc gcagcgcgct 420
ccgcccgggc gccccgctgc tgcccccgct gctgctgctg ctgctgtggg cgccgcctcc 480
gagccgcgca gctcagccag cagatctcct gaaggttcta gattttcaca acttgcctga 540
tggaataaca aagacaacag gcttttgcgc cacgcggcga tcttccaaag gcccggatgt 600
cgcttacaga gtcaccaaag acgcgcagct cagcgcaccc accaagcagc tgtaccctgc 660
gtctgcattt cccgaggact tctccatcct aacaactgtg aaagccaaga aaggcagcca 720
ggccttcctg gtctccatct acaacgagca gggtatccag cagattgggc tggagctggg 780
ccgctctccc gtcttcctct acgaggacca cacggggaag cctggcccgg aagactaccc 840
cctcttccgg ggcatcaacc tgtcagatgg caagtggcac agaattgctc tcagcgtcca 900
caagaaaaat gtcaccttga tcctcgactg taaaaagaag accaccaaat tcctcgaccg 960
cagcgaccac cccatgatcg acatcaatgg catcatcgtg tttggcaccc ggatcctgga 1020
tgaggaggtg tttgagggtg acatccagca gctgctcttt gtctcggacc accgggcagc 1080
ttatgattac tgtgagcact acagccctga ctgtgacacc gcagtacctg acaccccaca 1140
gtcgcaggac cccaatccag atgaatatta cacggaagga gacggcgagg gtgagaccta 1200
ttactacgaa tacccctact acgaagaccc cgaagaccta gggaaggagc ccacccccag 1260
caagaagccc gtggaagctg ccaaagaaac cacagaggtc cccgaggagc tgaccccgac 1320
ccccacggaa gctgctccca tgcctgaaac cagtgaaggg gctgggaagg aagaggacgt 1380
cggcatcggg gactatgact acgtgcccag tgaggactac tacacgccct caccgtatga 1440
tgacctcacc tatggcgagg gggaggagaa ccccgaccag cccacagacc caggcgctgg 1500
ggccgaaatt cccaccagca ccgccgacac ctccaactcc tccaatccag ctccgcctcc 1560
aggggaaggt gcggatgact tggaggggga gttcactgag gaaacgatcc ggaaccttga 1620
cgagaactac tacgacccct actacgaccc caccagctcc ccgtcggaga tcgggccggg 1680
aatgccggcg aaccaggata ccatctatga agggattgga ggacctcggg gcgagaaagg 1740
ccaaaaggga gaaccagcga ttatcgagcc gggcatgctc atcgagggcc cgcctggccc 1800
agaaggcccc gcgggtcttc ccggacctcc aggaaccatg ggtcccactg gccaagtcgg 1860
ggaccctgga gaaaggggcc cccctggacg cccaggcctt cctggggccg atggcctgcc 1920
cggtcctcca ggaaccatgc tcatgctgcc cttccggttt ggaggtggcg gcgatgcggg 1980
ctccaaaggc cccatggtct cagcccagga gtcccaggcg caagccattc tccagcaggc 2040
caggttggca ctgaggggac cagctggccc gatgggtctc acagggagac ctggccctgt 2100
gggtccccct gggagcggag gtttgaaggg cgagccggga gacgtggggc ctcagggtcc 2160
tcgaggtgtg caaggcccgc ctggtccggc cgggaagccc ggaagacggg gtcgggctgg 2220
gagtgatgga gccagaggaa tgcctggaca aactggcccc aagggtgacc ggggtttcga 2280
cggcctggct gggttgccag gcgagaaggg ccacaggggt gaccctggtc cttccggccc 2340
accaggacct ccgggagacg atggagaaag gggtgacgac ggagaagttg ggcccagggg 2400
gctgcctggg gagcccgggc cacgtggtct gcttgggccg aaggggcccc caggtcctcc 2460
cggacctccc ggtgtcacgg gtatggacgg ccagccgggg ccaaaaggaa atgtgggtcc 2520
ccagggagag cctggccccc caggacagca gggtaatcca ggcgcccagg gtcttccagg 2580
cccccagggt gcaattggtc ctccaggaga aaagggtccc ttggggaaac caggccttcc 2640
aggaatgccc ggtgctgacg gacccccggg acaccctggc aaagaaggcc ctccaggaga 2700
gaaaggaggt cagggtccac ctggccccca gggtccgatt ggctacccag gtcctcgagg 2760
agtcaagggg gccgatggca tccgtggtct gaagggcaca aagggcgaga agggtgaaga 2820
cggctttcct gggtttaaag gagacatggg catcaagggt gatcgggggg agatcggccc 2880
acccggtccc aggggagaag atggccctga aggcccaaag ggtcgcggag gtcccaatgg 2940
tgaccccggt cctctgggac cccctgggga gaagggaaaa ctcggagtcc cagggttacc 3000
agggtatcca ggaagacaag gaccaaaggg ctctattgga ttccctggat ttcctggcgc 3060
caatggagag aagggcggca gggggacccc tggaaagcca ggaccgcggg ggcagcgagg 3120
cccaacgggt ccgaggggtg aaagaggccc ccggggcatc actgggaagc ctggccccaa 3180
gggcaactcc ggaggtgacg gcccagctgg ccctcctggt gaacggggac ccaatggacc 3240
ccaaggaccc acaggatttc ctggaccaaa gggcccccct ggccctccag gcaaggatgg 3300
actcccagga caccctggac agagaggcga gactggtttc caaggcaaga ccggccctcc 3360
aggccccccc ggcgtggtcg gccctcaggg tcccacggga gaaacgggcc caatgggtga 3420
gcgtggccac cctgggcccc ctggaccccc cggtgaacag gggcttccgg gccttgctgg 3480
aaaagaaggg acgaagggtg acccaggccc tgcaggcctc cctgggaaag atggccctcc 3540
aggattacgt ggtttccctg gggaccgagg gcttcctggt ccagtgggag ctcttggact 3600
gaaaggcaat gaagggcccc ctggcccacc aggccctgcg ggatctccag gggagagagg 3660
tccagctgga gccgctgggc ccatcggaat tccagggaga cctgggcccc agggaccccc 3720
agggccggca ggagagaaag gggctcctgg cgagaaaggc ccacaaggcc cagctggccg 3780
agacggtctc caggggcctg tggggctccc gggtccagct ggccctgtgg gtccccctgg 3840
agaagacgga gataagggag agatcgggga gccggggcag aaaggaagca agggggacaa 3900
aggagaacag ggtcctcctg ggcctacagg tcctcaaggc cccatcggac agccaggccc 3960
ctctggagct gacggcgagc cggggcctcg gggccagcag ggccttttcg ggcagaaagg 4020
tgatgaaggt cccagaggct ttcctggacc ccctgggcca gtggggctgc agggtttgcc 4080
aggacctcca ggcgagaagg gtgagacagg agacgtgggc cagatgggcc ccccgggtcc 4140
ccctggcccc cgaggaccct ccggagctcc aggtgctgat ggcccacaag gtcccccagg 4200
tggaatagga aaccctggtg cagtgggaga gaagggcgag cctggcgaag caggtgagcc 4260
tggccttccg ggagaaggcg gccccccggg acccaaagga gaaaggggag agaagggcga 4320
gtcaggccct tcaggtgctg ccggaccccc tggacccaaa ggccctcccg gagatgatgg 4380
tcccaaaggc agccctggcc cagtgggttt tcctggagat cctggccccc ccggagagcc 4440
tggccccgcg ggtcaagatg gtccccctgg tgacaaagga gatgatggtg aacccgggca 4500
gacgggatcc cccggcccta ctggtgaacc aggtccatcg gggcctccag gaaaaagggg 4560
tcccccaggc cccgcaggcc ccgaaggcag acagggagag aaaggggcca agggagaagc 4620
cggcttggaa ggccctcctg ggaagactgg ccccatcggc ccccaggggg cccctgggaa 4680
gcccggaccg gatggccttc gagggatccc tggccctgtg ggagaacaag gtctcccagg 4740
atccccaggc ccggacggtc cccccggccc catgggtccc ccaggacttc ccggcctcaa 4800
aggagattct ggtcccaaag gtgaaaaggg tcatccaggc ctgatcgggc tcatcggtcc 4860
tccgggtgaa cagggtgaga agggcgaccg tggtctccct ggcccccagg gctcctccgg 4920
tcctaaggga gaacagggta tcactggtcc ttctggcccg attgggcctc ctgggccccc 4980
tggcctgccg ggtccgcctg gtccaaaagg tgctaagggc tcctcgggtc caactggccc 5040
gaagggtgag gcaggccacc caggaccccc aggccccccg ggccccccgg gagaggtcat 5100
ccagcccctg ccaatccagg catccaggac gcggcggaac atcgacgcca gccagctgct 5160
ggacgacggg aatggcgaga actacgtgga ctacgcggac ggcatggaag agatcttcgg 5220
ctctctcaac tctctgaagc tggagattga gcagatgaaa cggcccctgg gcacgcagca 5280
gaaccccgcc cgcacctgca aggacctgca gctctgccac cccgacttcc cagatggtga 5340
atactgggtc gatcctaacc aaggatgctc cagggattcc ttcaaggttt actgcaactt 5400
cacagccggg gggtcgacat gcgtcttccc tgacaagaag tccgaagggg ccagaatcac 5460
ttcttggccc aaagaaaacc cgggctcctg gttcagtgaa ttcaagcgtg ggaaactgct 5520
ctcctatgtg gacgccgagg gcaaccctgt gggtgtggta cagatgacct tcctgcggct 5580
gctgagcgcc tctgcccacc agaacgtcac ctaccactgc taccagtcag tggcctggca 5640
ggacgcagcc acgggcagct acgacaaggc cctccgcttc ctgggctcca acgacgagga 5700
gatgtcctat gacaacaacc cctacatccg cgccctggtg gacggctgtg ctaccaagaa 5760
aggctaccag aagacggttc tggagatcga cacccccaaa gtggagcagg tgcccatcgt 5820
ggacatcatg ttcaatgact tcggtgaagc gtcacagaaa tttggatttg aagtggggcc 5880
ggcttgcttc atgggctagg agccgccgag cccgggctcc cgagagcaac ctcgtgacct 5940
cagcatgcca ttcgttcgtg agtgtcccgt gcacgtcctg accctggaca gtgaaggctt 6000
ctccctcccc tcccacctga cttcatctac gcctcggcac cacggggtgt gggaccccag 6060
cccggagaga acagagggaa ggagccgcgc ccccacctgg agctgaatca catgacctag 6120
ctgcacccca gcgcctgggc ccgccccacg ctctgtccac acccacgcgc cccgggagcg 6180
gggccatgcc tccagccccc cagctcgccc gacccatcct gttcgtgaat aggtctcagg 6240
ggttggggga gggactgcca gatttggaca ctatattttt ttctaaattc aacttgaaga 6300
tgtgtatttc ccctgacctt caaaaaatgt tccaaggtaa gcctcgtaaa ggtcatccca 6360
ccatcaccaa agcctccgtt tttaacaacc tccaacacga tccatttaga ggccaaatgt 6420
cattctgcag gtgccttccc gatggattaa aggtgcttat gtttttgtga gttttaagta 6480
aatatttgta ttgtattgtt ataaatgtta agtgtgcctg gctttcaatc atgcacggaa 6540
acccagtctc agtcccacgg acagaatggg cgaggcatgg attctgggtt gcagtaccgt 6600
tctgattaga aataggaagt ctccccaccc ccgccctggc caagaacgtg caataaattg 6660
gaagtttgcc ccggggcagc aagaatttat gctgccattg aaaagcaggt accagtgccc 6720
cttttcagac agtttttgat tcgctctaga cttttttttt ttttaatagg gaaaaaattt 6780
gataattttc ttttttctac atgcacttaa gactaaaaca caggtttgga ttaattttat 6840
ttgcttcctt tttccgcttt tcttcccgca gagcctgatg ggagaatgtc cagggcaggg 6900
aaaccacatt ttttgtaggt gataactcaa tgaaaattgg tgcttatttt ttacacttct 6960
ctcttgtggc tctcttgtgg tgctatctat ctgttttaag gtctccttga aggcgcactg 7020
gggaccctgg ccatgcctcg ttctccctgc tttctttatc ctgttattgc ctccacagtc 7080
tgttgccaag gactctaaga tcaatgcacg tcactttcct ttccactggg caggatagcc 7140
aagcacactc cctcctgcgc tctcccgccc cggtgcgtcc actcccgagg gctgttatga 7200
ggactgggtt gtgcctactt gatttgaaaa cacacacaag caataaaaag cctcttcctg 7260
cattgtctgt ggtgtgacca tagcagatta tatttggttc ctgaatgttt gtggtgctaa 7320
tttctgtgtt tgttccaagc cgttcagtca tgccatgcgc tgcctcggta gatggagtaa 7380
tgtacaatga actccatgag tctctccagg gctgcctgca gcacgtcttt tccaagtagc 7440
ctatttggat tcccatctca aatgtcctgg atgcgagcgt cagcggctcc agagctcggg 7500
gcgggtgagg tcccctttgg ggaacccttt cctggccatc gaggtcgggg ggctgccgtc 7560
tgtgggcagg aggacccgag gggcagccag gaaaggcgat ctcttcactg tgaaaagttg 7620
cccgggtgca gcgccttttc cttctaccat gggaaatgca ggctgggccc ttggggtgag 7680
cctgcggggc tctggtgctg tccccgaccc ccaccaccac cagaatgcag ttccagctta 7740
ggaagccaca aacaagccac ccaggaggaa caaaacaccg ccagcgtgga ttttccaaat 7800
ttccctggaa agtaagtctc gctcttgcca aagaaaagtc tggcttggag agtctctgga 7860
gcccaggatg ccagcatgtg ccaatgactg tcaccttcat ctcttcaaaa gaaaagccat 7920
agccgaggac tgtcccgcga cccccgtgga ctgcgtctag gtcatgtgat tctgttttca 7980
tttctcatcc catccaattt gtccttttct cctgtcattt tcttcctctg tggtcccttc 8040
aaagttgtta taatttgtac tgaacttcaa aatgtgtccc gttctcccca gaccactcta 8100
gccacagtat attgcaataa aattacttct tatatttgca gaaattcttt tggtgtaatt 8160
ttattttttc ctctcaatat atataattgg acaaacgctg gcaaaaagaa aaaaatggta 8220
agcaaaaaac ccaagataaa gtttcgagga catcaggcct tttgaaatac aatgtcaaat 8280
gacacattgt acggtttcaa aaaatccgct agacatgtca taagttttaa ctgtaatgcc 8340
caggaaagga tatcttaaaa tattctaaac ttgtgtaaca aaggaataat taactgtaat 8400
agtttttcaa taaatcgagt tgggtgtttc caccgtaaa                        8439

<210> 2
<211> 1838
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly
 1               5                  10                  15      
Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro
            20                  25                  30          
Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe
        35                  40                  45              
His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr
    50                  55                  60                  
Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp
65                  70                  75                  80  
Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe
                85                  90                  95      
Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser
            100                 105                 110         
Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile
        115                 120                 125             
Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr
    130                 135                 140                 
Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu
145                 150                 155                 160 
Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn
                165                 170                 175     
Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp
            180                 185                 190         
Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly
        195                 200                 205             
Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu
    210                 215                 220                 
Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr
225                 230                 235                 240 
Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp
                245                 250                 255     
Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr
            260                 265                 270         
Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys
        275                 280                 285             
Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr
    290                 295                 300                 
Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met
305                 310                 315                 320 
Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly
                325                 330                 335     
Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr
            340                 345                 350         
Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr
        355                 360                 365             
Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser
    370                 375                 380                 
Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu
385                 390                 395                 400 
Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr
                405                 410                 415     
Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro
            420                 425                 430         
Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro
        435                 440                 445             
Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly
    450                 455                 460                 
Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro
465                 470                 475                 480 
Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly
                485                 490                 495     
Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu
            500                 505                 510         
Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly
        515                 520                 525             
Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser
    530                 535                 540                 
Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro
545                 550                 555                 560 
Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro
                565                 570                 575     
Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly
            580                 585                 590         
Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg
        595                 600                 605             
Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr
    610                 615                 620                 
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly
625                 630                 635                 640 
Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro
                645                 650                 655     
Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg
            660                 665                 670         
Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly
        675                 680                 685             
Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln
    690                 695                 700                 
Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro
705                 710                 715                 720 
Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly
                725                 730                 735     
Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu
            740                 745                 750         
Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu
        755                 760                 765             
Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly
    770                 775                 780                 
Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile
785                 790                 795                 800 
Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro
                805                 810                 815     
Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly
            820                 825                 830         
Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg
        835                 840                 845             
Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys
    850                 855                 860                 
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly
865                 870                 875                 880 
Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu
                885                 890                 895     
Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg
            900                 905                 910         
Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly
        915                 920                 925             
Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro
    930                 935                 940                 
Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro
945                 950                 955                 960 
Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly
                965                 970                 975     
His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro
            980                 985                 990         
Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr
        995                 1000                1005            
Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly
    1010                1015                1020                
Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys Gly Asp
1025                1030                1035               1040 
Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro Gly Leu Arg
                1045                1050                1055    
Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val Gly Ala Leu Gly
            1060                1065                1070        
Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Ser
        1075                1080                1085            
Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala Gly Pro Ile Gly Ile Pro
    1090                1095                1100                
Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly
1105                1110                1115               1120 
Ala Pro Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly Leu
                1125                1130                1135    
Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Val Gly Pro Pro
            1140                1145                1150        
Gly Glu Asp Gly Asp Lys Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly
        1155                1160                1165            
Ser Lys Gly Asp Lys Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro
    1170                1175                1180                
Gln Gly Pro Ile Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro
1185                1190                1195               1200 
Gly Pro Arg Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly
                1205                1210                1215    
Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu
            1220                1225                1230        
Pro Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met
        1235                1240                1245            
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro Gly
    1250                1255                1260                
Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro Gly Ala
1265                1270                1275               1280 
Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro Gly Leu Pro
                1285                1290                1295    
Gly Glu Gly Gly Pro Pro Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly
            1300                1305                1310        
Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Pro Lys Gly Pro
        1315                1320                1325            
Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro Gly Pro Val Gly Phe Pro
    1330                1335                1340                
Gly Asp Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Gln Asp Gly
1345                1350                1355               1360 
Pro Pro Gly Asp Lys Gly Asp Asp Gly Glu Pro Gly Gln Thr Gly Ser
                1365                1370                1375    
Pro Gly Pro Thr Gly Glu Pro Gly Pro Ser Gly Pro Pro Gly Lys Arg
            1380                1385                1390        
Gly Pro Pro Gly Pro Ala Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly
        1395                1400                1405            
Ala Lys Gly Glu Ala Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro
    1410                1415                1420                
Ile Gly Pro Gln Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg
1425                1430                1435               1440 
Gly Ile Pro Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly
                1445                1450                1455    
Pro Asp Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu
            1460                1465                1470        
Lys Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile
        1475                1480                1485            
Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg Gly
    1490                1495                1500                
Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln Gly Ile
1505                1510                1515               1520 
Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Pro
                1525                1530                1535    
Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser Gly Pro Thr Gly
            1540                1545                1550        
Pro Lys Gly Glu Ala Gly His Pro Gly Pro Pro Gly Pro Pro Gly Pro
        1555                1560                1565            
Pro Gly Glu Val Ile Gln Pro Leu Pro Ile Gln Ala Ser Arg Thr Arg
    1570                1575                1580                
Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly Asn Gly Glu Asn
1585                1590                1595               1600 
Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe Gly Ser Leu Asn
                1605                1610                1615    
Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro Leu Gly Thr Gln
            1620                1625                1630        
Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu Cys His Pro Asp
        1635                1640                1645            
Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg
    1650                1655                1660                
Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys
1665                1670                1675               1680 
Val Phe Pro Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro
                1685                1690                1695    
Lys Glu Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu
            1700                1705                1710        
Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met
        1715                1720                1725            
Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr Tyr
    1730                1735                1740                
His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr
1745                1750                1755               1760 
Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr
                1765                1770                1775    
Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly Cys Ala Thr Lys
            1780                1785                1790        
Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp Thr Pro Lys Val Glu
        1795                1800                1805            
Gln Val Pro Ile Val Asp Ile Met Phe Asn Asp Phe Gly Glu Ala Ser
    1810                1815                1820                
Gln Lys Phe Gly Phe Glu Val Gly Pro Ala Cys Phe Met Gly
1825                1830                1835            


<210> 3
<211> 6930
<212> DNA
<213> Homo sapiens

<400> 3
gaccgttgct tggcagacac tggatggtta tgagcctgaa caagctgaaa aggggcagga 60
aaagaagtgg aggcagcatt cttcctattt aaagctgcat cgcttgaaaa aagttttcgc 120
agactgtgct ggagctggtg ctgaaaaagg gggtttgcag aggctgccct ggggctggtg 180
ctgaaagaag agcccacagc tgacttcatg gtgctacaat aacctcagaa tctacttttc 240
actctcagga gaacccacat gtctaatatt tagacatgat ggcaaactgg gcggaagcaa 300
gacctctcct cattcttatt gttttattag ggcaatttgt ctcaataaaa gcccaggaag 360
aagacgagga tgaaggatat ggtgaagaaa tagcctgcac tcagaatggc cagatgtact 420
taaacaggga catttggaaa cctgcccctt gtcagatctg tgtctgtgac aatggagcca 480
ttctctgtga caagatagaa tgccaggatg tgctggactg tgccgaccct gtaacgcccc 540
ctggggaatg ctgtcctgtc tgttcacaaa cacctggagg tggcaataca aattttggta 600
gaggaagaaa gggacaaaag ggagaaccag gattagtgcc tgttgtaaca ggcatacgtg 660
gtcgtccagg accggcagga cctccaggat cacagggacc aagaggagag cgagggccaa 720
aaggaagacc tggccctcgt ggacctcagg gaattgatgg agaaccaggt gttcctggtc 780
aacctggtgc tccaggacct cctggacatc cgtcccaccc aggacccgat ggcttgagca 840
ggccgttttc agctcaaatg gctgggttgg atgaaaaatc tggacttggg agtcaagtag 900
gactaatgcc tggctctgtg ggtcctgttg gcccaagggg accacagggt ttacaaggac 960
agcaaggtgg tgcaggacct acaggacctc ctggtgaacc tggtgatcct ggaccaatgg 1020
gtccgattgg ttcacgtgga ccagagggcc ctcctggtaa acctggggaa gatggtgaac 1080
ctggcagaaa tggaaatcct ggtgaagtgg gatttgcagg atctccggga gctcgtggat 1140
ttcctggggc tcctggtctt ccaggtctga agggtcaccg aggacacaaa ggtcttgaag 1200
gccctaaagg tgaagttgga gcacctggtt ccaagggtga agctggcccc actggtccaa 1260
tgggtgccat gggtcctctg ggtccgaggg gaatgccagg agagagaggg agacttgggc 1320
cacagggtgc tcctggacaa cgaggtgcac atggtatgcc tggaaaacct ggaccaatgg 1380
gtcctcttgg gataccaggc tcttctggtt ttccaggaaa tcctggaatg aagggagaag 1440
caggtcctac aggggcgcga ggccctgaag gtcctcaggg gcagagaggt gaaactgggc 1500
ccccaggtcc agttggctct ccaggtcttc ctggtgcaat aggaactgat ggtactcctg 1560
gtgccaaagg cccaacgggc tctccgggta cctctggtcc tcctggctca gcagggcctc 1620
ctggatctcc aggacctcag ggtagcactg gtcctcaggg aattcgaggc caaccgggtg 1680
atccaggagt tccaggtttc aaaggagaag ctggcccaaa aggggaacca gggccacatg 1740
gtattcaggg tccgataggc ccacccggtg aagaaggcaa aagaggtccc agaggtgacc 1800
caggaacagt tggtcctcca gggccagtgg gagaaagggg tgctcctggc aatcgtggtt 1860
ttccaggctc tgatggttta cctgggccaa agggtgctca aggagaacgg ggtcctgtag 1920
gttcttcagg acccaaagga agccaggggg atccaggacg tccaggggaa cctgggcttc 1980
caggtgctcg gggtttgaca ggaaatcctg gtgttcaagg tcctgaagga aaacttggac 2040
ctttgggtgc gccaggggaa gatggccgtc caggtcctcc aggctccata ggaatcagag 2100
ggcagcccgg gagcatgggc cttccaggcc ccaaaggtag cagtggtgac cctgggaaac 2160
ctggagaagc aggaaatgct ggagttcctg ggcagagggg agctcctgga aaagatggtg 2220
aagttggtcc ttctggtcct gtgggcccgc cgggtctagc tggtgaaaga ggagaacaag 2280
gacctccagg ccccacaggt tttcaggggc ttcctggtcc tccagggcct cctggagaag 2340
gtggaaaacc aggtgatcaa ggtgttcctg gagatcccgg agcagttggc ccgttaggac 2400
ctagaggaga acgaggaaat cctggggaaa gaggagaacc tgggataact ggactccctg 2460
gtgagaaggg aatggctgga ggacatggtc ctgatggccc aaaaggcagt ccaggtccat 2520
ctgggacccc tggagataca ggcccaccag gtcttcaagg tatgccggga gaaagaggaa 2580
ttgcaggaac tcctggcccc aagggtgaca gaggtggcat aggagaaaaa ggtgctgaag 2640
gcacagctgg aaatgatggt gcaagaggtc ttccaggtcc tttgggccct ccaggtccgg 2700
caggtcctac tggagaaaag ggtgaacctg gtcctcgagg tttagttggc cctcctggct 2760
cccggggcaa tcctggttct cgaggtgaaa atgggccaac tggagctgtt ggttttgccg 2820
gaccccaggg tcctgacgga cagcctggag taaaaggtga acctggagag ccaggacaga 2880
agggagatgc tggttctcct ggaccacaag gtttagcagg atcccctggc cctcatggtc 2940
ctaatggtgt tcctggacta aaaggtggtc gaggaaccca aggtccgcct ggtgctacag 3000
gatttcctgg ttctgcgggc agagttggac ctccaggccc tgctggagct ccaggacctg 3060
cgggacccct aggggaaccc gggaaggagg gacctccagg tcttcgtggg gaccctggct 3120
ctcatgggcg tgtgggagat cgaggaccag ctggcccccc tggtggccca ggagacaaag 3180
gggacccagg agaagatggg caacctggtc cagatggccc ccctggtcca gctggaacga 3240
ccgggcagag aggaattgtt ggcatgcctg ggcaacgtgg agagagaggc atgcccggcc 3300
taccaggccc agcgggaaca ccaggaaaag taggaccaac tggtgcaaca ggagataaag 3360
gtccacctgg acctgtgggg cccccaggct ccaatggtcc tgtaggggaa cctggaccag 3420
aaggtccagc tggcaatgat ggtaccccag gacgggatgg tgctgttgga gaacgtggtg 3480
atcgtggaga ccctgggcct gcaggtctgc caggctctca gggtgcccct ggaactcctg 3540
gccctgtggg tgctccagga gatgcaggac aaagaggaga tccgggttct cggggtccta 3600
taggaccacc tggtcgagct gggaaacgtg gattacctgg accccaagga cctcgtggtg 3660
acaaaggtga tcatggagac cgaggcgaca gaggtcagaa gggccacaga ggctttactg 3720
gtcttcaggg tcttcctggc cctcctggtc caaatggtga acaaggaagt gctggaatcc 3780
ctggaccatt tggcccaaga ggtcctccag gcccagttgg tccttcaggt aaagaaggaa 3840
accctgggcc acttgggcca attggacctc caggtgtacg aggcagtgta ggagaagcag 3900
gacctgaggg ccctcctggt gagcctggcc cacctggccc tccgggtccc cctggccacc 3960
ttacagctgc tcttggggat atcatggggc actatgatga aagcatgcca gatccacttc 4020
ctgagtttac tgaagatcag gcggctcctg atgacaaaaa caaaacggac ccaggggttc 4080
atgctaccct gaagtcactc agtagtcaga ttgaaaccat gcgcagcccc gatggctcga 4140
aaaagcaccc agcccgcacg tgtgatgacc taaagctttg ccattccgca aagcagagtg 4200
gtgaatactg gattgatcct aaccaaggat ctgttgaaga tgcaatcaaa gtttactgca 4260
acatggaaac aggagaaaca tgtatttcag caaacccatc cagtgtacca cgtaaaacct 4320
ggtgggccag taaatctcct gacaataaac ctgtttggta tggtcttgat atgaacagag 4380
ggtctcagtt cgcttatgga gaccaccaat cacctaatac agccattact cagatgactt 4440
ttttgcgcct tttatcaaaa gaagcctccc agaacatcac ttacatctgt aaaaacagtg 4500
taggatacat ggacgatcaa gctaagaacc tcaaaaaagc tgtggttctc aaaggggcaa 4560
atgacttaga tatcaaagca gagggaaata ttagattccg gtatatcgtt cttcaagaca 4620
cttgctctaa gcggaatgga aatgtgggca agactgtctt tgaatataga acacagaatg 4680
tggcacgctt gcccatcata gatcttgctc ctgtggatgt tggcggcaca gaccaggaat 4740
tcggcgttga aattgggcca gtttgttttg tgtaaagtaa gccaagacac atcgacaatg 4800
agcaccacca tcaatgacca ccgccattca caagaacttt gactgtttga agttgatcct 4860
gagactcttg aagtaatggc tgatcctgca tcagcattgt atatatggtc ttaagtgcct 4920
ggcctcctta tccttcagaa tatttatttt acttacaatc ctcaagtttt aattgatttt 4980
aaatattttt caatacaaca gtttaggttt aagatgacca atgacaatga ccacctttgc 5040
agaaagtaaa ctgattgaat aaataaatct ccgttttctt caatttattt cagtgtaatg 5100
aaaaagttgc ttagtattta tgaggaaatt cttcttcctg gcaggtagct taaagagtgg 5160
ggtatataga gccacaacac atgtttattt tgcttggctg cagttgaaaa atagaaatta 5220
gtgccctttt gtgacctctc attccaagat tgtcaattaa aaatgagttt aaaatgttta 5280
acttgtgatc gagacctaca tgcatgtctt gatattgtgt aactataata gagactcttt 5340
aaggagaatc ttaaaaaaaa aaaaacgttt ctcactgtct taaatagaat ttttaaatag 5400
tatatattca gtggcatttt ggagaacaaa gtgaatttac ttcgacttct taaatttttg 5460
taaaagacta taagtttaga catctttctc attcaaattt aaagatatct ttctcctctt 5520
gatcaatcta tcaatattga tagaagtcac actagtatat accatttaat acatttacac 5580
tttcttattt aagaagatat tgaatgcaaa ataattgaca tatagaactt tacaaacata 5640
tgtccaagga ctctaaattg agactcttcc acatgtacaa tctcatcatc ctgaagccta 5700
taatgaagaa aaagatctag aaactgagtt gtggagctga ctctaatcaa atgtgatgat 5760
tggaattaga ccatttggcc tttgaacttt cataggaaaa atgacccaac atttcttagc 5820
atgagctacc tcatctctag aagctgggat ggacttacta ttcttgttta tattttagat 5880
actgaaaggt gctatgcttc tgttattatt ccaagactgg agataggcag ggctaaaaag 5940
gtattattat ttttccttta atgatggtgc taaaattctt cctataaaat tccttaaaaa 6000
taaagatggt ttaatcacta ccattgtgaa aacataactg ttagacttcc cgtttctgaa 6060
agaaagagca tcgttccaat gcttgttcac tgttcctctg tcatactgta tctggaatgc 6120
tttgtaatac ttgcatgctt cttagaccag aacatgtagg tccccttgtg tctcaatact 6180
ttttttttct taattgcatt tgttggctct attttaattt ttttctttta aaataaacag 6240
ctgggaccat cccaaaagac aagccatgca tacaactttg gtcatgtatc tctgcaaagc 6300
atcaaattaa atgcacgctt ttgtcatgtc agtggttttt gttttgtgaa attcctttga 6360
ccatattaga tctatttcat ttccaatagt gaaaaggaga tgtggtggta tactttgttt 6420
gccatttgtt taaaagatac aacggatacc ttctatcatg tatgtactgg cttataaatg 6480
aaaatctatc tacaacatta cccacaaagg caacatgaca ccaattatca ctgcctctgc 6540
ccttaaaaat gtcagagtag tattattgat aaaaagggca agcaatagat ttttcatgac 6600
tgaataaact gtaataataa aacatatgtc tcaaagtgta tcacatatga atttagccta 6660
attgttttca gtttcattct caatatttag tttacaacat cattttcccc taaactggtt 6720
atattttgac ctgtatatct taaatttgag tatttatatg cctaaataca tgtgtgagtt 6780
ttgtttgact tccaagtcca aactataaga ttatataagt tcatatagat gaatcagaaa 6840
tatgtggtaa tactattaag tcacaaacac taacaatttc caactataga aataacagtt 6900
cttatttgga ttttgggaat gctaccaata                                  6930

<210> 4
<211> 1499
<212> PRT
<213> Homo sapiens

<400> 4
Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val
 1               5                  10                  15      
Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp
            20                  25                  30          
Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr
        35                  40                  45              
Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys
    50                  55                  60                  
Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu
65                  70                  75                  80  
Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys
                85                  90                  95      
Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys
            100                 105                 110         
Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg
        115                 120                 125             
Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly
    130                 135                 140                 
Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile
145                 150                 155                 160 
Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro
                165                 170                 175     
Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser
            180                 185                 190         
Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val
        195                 200                 205             
Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln
    210                 215                 220                 
Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly
225                 230                 235                 240 
Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro
                245                 250                 255     
Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn
            260                 265                 270         
Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly
        275                 280                 285             
Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His
    290                 295                 300                 
Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys
305                 310                 315                 320 
Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly
                325                 330                 335     
Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala
            340                 345                 350         
Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met
        355                 360                 365             
Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly
    370                 375                 380                 
Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro
385                 390                 395                 400 
Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro
                405                 410                 415     
Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly
            420                 425                 430         
Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro
        435                 440                 445             
Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg
    450                 455                 460                 
Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly
465                 470                 475                 480 
Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro
                485                 490                 495     
Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val
            500                 505                 510         
Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly
        515                 520                 525             
Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu
    530                 535                 540                 
Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro
545                 550                 555                 560 
Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly
                565                 570                 575     
Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala
            580                 585                 590         
Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg
        595                 600                 605             
Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly
    610                 615                 620                 
Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln
625                 630                 635                 640 
Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val
                645                 650                 655     
Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly
            660                 665                 670         
Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu
        675                 680                 685             
Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val
    690                 695                 700                 
Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly
705                 710                 715                 720 
Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly
                725                 730                 735     
His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro
            740                 745                 750         
Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly
        755                 760                 765             
Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu
    770                 775                 780                 
Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro
785                 790                 795                 800 
Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly
                805                 810                 815     
Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn
            820                 825                 830         
Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala
        835                 840                 845             
Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly
    850                 855                 860                 
Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu
865                 870                 875                 880 
Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys
                885                 890                 895     
Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly
            900                 905                 910         
Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro
        915                 920                 925             
Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg
    930                 935                 940                 
Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly
945                 950                 955                 960 
Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln
                965                 970                 975     
Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg
            980                 985                 990         
Gly Ile Val Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly
        995                 1000                1005            
Leu Pro Gly Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala
    1010                1015                1020                
Thr Gly Asp Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn
1025                1030                1035               1040 
Gly Pro Val Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly
                1045                1050                1055    
Thr Pro Gly Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly Asp
            1060                1065                1070        
Pro Gly Pro Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly Thr Pro
        1075                1080                1085            
Gly Pro Val Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly Asp Pro Gly
    1090                1095                1100                
Ser Arg Gly Pro Ile Gly Pro Pro Gly Arg Ala Gly Lys Arg Gly Leu
1105                1110                1115               1120 
Pro Gly Pro Gln Gly Pro Arg Gly Asp Lys Gly Asp His Gly Asp Arg
                1125                1130                1135    
Gly Asp Arg Gly Gln Lys Gly His Arg Gly Phe Thr Gly Leu Gln Gly
            1140                1145                1150        
Leu Pro Gly Pro Pro Gly Pro Asn Gly Glu Gln Gly Ser Ala Gly Ile
        1155                1160                1165            
Pro Gly Pro Phe Gly Pro Arg Gly Pro Pro Gly Pro Val Gly Pro Ser
    1170                1175                1180                
Gly Lys Glu Gly Asn Pro Gly Pro Leu Gly Pro Ile Gly Pro Pro Gly
1185                1190                1195               1200 
Val Arg Gly Ser Val Gly Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu
                1205                1210                1215    
Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala
            1220                1225                1230        
Leu Gly Asp Ile Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu
        1235                1240                1245            
Pro Glu Phe Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr
    1250                1255                1260                
Asp Pro Gly Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu
1265                1270                1275               1280 
Thr Met Arg Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys
                1285                1290                1295    
Asp Asp Leu Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr Trp
            1300                1305                1310        
Ile Asp Pro Asn Gln Gly Ser Val Glu Asp Ala Ile Lys Val Tyr Cys
        1315                1320                1325            
Asn Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Ser Ser Val
    1330                1335                1340                
Pro Arg Lys Thr Trp Trp Ala Ser Lys Ser Pro Asp Asn Lys Pro Val
1345                1350                1355               1360 
Trp Tyr Gly Leu Asp Met Asn Arg Gly Ser Gln Phe Ala Tyr Gly Asp
                1365                1370                1375    
His Gln Ser Pro Asn Thr Ala Ile Thr Gln Met Thr Phe Leu Arg Leu
            1380                1385                1390        
Leu Ser Lys Glu Ala Ser Gln Asn Ile Thr Tyr Ile Cys Lys Asn Ser
        1395                1400                1405            
Val Gly Tyr Met Asp Asp Gln Ala Lys Asn Leu Lys Lys Ala Val Val
    1410                1415                1420                
Leu Lys Gly Ala Asn Asp Leu Asp Ile Lys Ala Glu Gly Asn Ile Arg
1425                1430                1435               1440 
Phe Arg Tyr Ile Val Leu Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn
                1445                1450                1455    
Val Gly Lys Thr Val Phe Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu
            1460                1465                1470        
Pro Ile Ile Asp Leu Ala Pro Val Asp Val Gly Gly Thr Asp Gln Glu
        1475                1480                1485            
Phe Gly Val Glu Ile Gly Pro Val Cys Phe Val
    1490                1495                


<210> 5
<211> 6192
<212> DNA
<213> Homo sapiens

<400> 5
gcgagtgact gcaccgagcc cgagaagtcg ccgcgccccg cagccgcccc gactggttcc 60
ccgccttgcc cgtgggcccc gccgggatgg ggaaccgccg ggacctgggc cagccgcggg 120
ccggtctctg cctgctcctg gccgcgctgc agcttctgcc ggggacgcag gccgatcctg 180
tggatgtcct gaaggccctg ggtgtgcagg gaggccaggc tggggtcccc gaggggcctg 240
gcttctgtcc ccagaggact ccagagggtg accgggcatt cagaattggc caggccagca 300
cgctcggcat ccccacgtgg gaactctttc cagaaggcca ctttcctgag aacttctcct 360
tgctgatcac cttgcgggga cagccagcca atcagtctgt cctgctgtcc atttatgatg 420
aaaggggtgc ccggcagttg ggcctggcac tggggccagc gctgggtctc ctaggtgacc 480
ccttccgccc cctcccccag caggtcaacc tcacagatgg caggtggcac cgtgtggccg 540
tcagcataga tggtgagatg gtgaccctgg tagctgactg tgaagctcag ccccctgttt 600
tgggccatgg cccccgcttc atcagcatag ctggactcac tgtgctgggg acccaggacc 660
ttggggaaaa gactttcgag ggagacattc aggagctgct gataagccca gatcctcagg 720
ctgccttcca ggcttgtgag cggtacctcc ccgactgtga caacctggca ccggcagcca 780
cagtggctcc ccagggtgaa ccagaaaccc ctcgtcctcg gcggaagggg aagggaaaag 840
ggaggaagaa agggcgaggt cgcaagggga agggcaggaa aaagaacaag gaaatttgga 900
cctcaagtcc acctcctgac tccgcagaga accagacctc cactgacatc cccaagacag 960
agactccagc tccaaatctg cctccgaccc ccacgccttt ggtcgtcacc tccactgtga 1020
ctactggact caatgccacg atcctagaga ggagcttgga ccctgacagt ggaaccgagc 1080
tggggaccct ggagaccaag gcagccaggg aggatgaaga aggagatgat tccaccatgg 1140
gccctgactt ccgggcagca gaatatccat ctcggactca gttccagatc tttcctggtg 1200
ctggagagaa aggagcaaaa ggagagcccg cagtgattga aaaggggcag cagtttgagg 1260
gacctccagg agccccagga ccccaagggg tggttggccc ctcaggccct cccggccccc 1320
caggattccc tggcgaccct ggtccaccgg gccctgctgg cctcccagga atccccggca 1380
ttgatgggat ccgaggccca ccgggcactg tgatcatgat gccgttccag tttgcaggcg 1440
gctcctttaa aggcccccca gtctcattcc agcaggccca ggctcaggca gttctgcagc 1500
agactcagct ctctatgaaa ggcccccctg gtccagtggg gctcactggg cgcccaggcc 1560
ctgtgggtct ccccgggcat ccaggtctga aaggagagga gggagcagaa gggccacagg 1620
gtccccgagg cctgcaggga cctcatggac cccctggccg agtgggcaag atgggccgcc 1680
ctggagcaga tggagctcgg ggcctcccag gggacactgg acctaagggt gatcgtggct 1740
tcgatggcct ccctgggctg cctggtgaga agggccaaag gggtgacttt ggccatgtgg 1800
ggcaacccgg tcccccagga gaggatggtg agaggggagc agagggacct ccagggccca 1860
ctggccaggc tggggagccg ggtccacgag gactgcttgg ccccagaggc tctcctggcc 1920
ccacgggtcg cccgggtgtg actggaattg atggtgctcc tggtgccaaa ggcaatgtgg 1980
gtcctccagg agaaccaggc cctccgggac agcagggaaa ccatgggtcc cagggactcc 2040
ccggtcccca gggactcatt ggcactcctg gggagaaggg tccccctgga aacccaggaa 2100
ttccaggcct cccaggatcc gatggccctc tgggtcaccc aggacatgag ggccccacgg 2160
gagagaaagg ggctcagggt ccaccagggt cggcaggccc tccgggctat cctggacctc 2220
ggggagtgaa gggcacttca ggcaaccggg gcctccaggg ggagaaaggc gagaagggag 2280
aggacggctt cccaggcttc aagggcgatg tggggctcaa aggtgatcag gggaaacccg 2340
gagctccagg tccccgggga gaggatggtc ctgaggggcc gaaggggcag gcggggcagg 2400
ctggcgagga ggggccccca ggctcagctg gggagaaggg caagcttggg gtgccaggcc 2460
tcccaggtta tccaggacgc cctggaccta agggatctat tggatttccc ggtcccctgg 2520
gacccatagg agagaaaggg aagtcgggaa agacagggca gccaggcctg gaaggagagc 2580
ggggaccacc aggttcccgt ggagagaggg ggcaaccggg tgccacaggg caaccaggcc 2640
ccaagggcga tgtgggccag gatggagccc ctgggatccc tggagaaaag ggcctccctg 2700
gtctgcaagg ccctccagga ttccctgggc caaagggccc ccctggtcac caaggtaaag 2760
atgggcgacc agggcaccct ggacagagag gagaactggg cttccaaggt cagacaggcc 2820
cgcctggacc agctggtgtc ttaggccctc agggaaagac aggagaagtg ggacctctag 2880
gtgaaagggg gcctccaggc ccccctggac ctcctggtga acaaggtctt cctggcctgg 2940
aaggcagaga gggggccaag ggggaactgg gaccaccagg accccttggg aaagaagggc 3000
cagctggact caggggcttt cccggcccca aagggggccc tggggacccg ggacctactg 3060
gcttaaaggg tgataagggc cccccagggc ccgtgggggc caatggctcc cctggtgagc 3120
gcggtccttt gggcccagca ggaggcattg gacttcctgg ccaaagtggc agcgaaggcc 3180
ccgttggccc tgcaggcaag aaggggtccc ggggagaacg tggcccccct ggccccactg 3240
gcaaagatgg gatcccaggg cccctggggc ctctgggacc ccctggagct gctgggcctt 3300
ctggcgagga aggggacaag ggggatgtgg gtgcccccgg acacaagggg agtaaaggcg 3360
ataaaggaga cgcgggccca cctggacaac cagggatacg gggtcctgca ggacacccag 3420
gtcccccggg agcagacggg gctcaggggc gccggggacc cccaggcctc tttgggcaga 3480
aaggagatga cggagtcaga ggctttgtgg gggtgattgg ccctcctgga ctgcaggggc 3540
tgccaggccc tccgggagag aaaggggagg tcggagacgt cgggtccatg ggtccccatg 3600
gagctccagg tcctcggggt ccccaaggcc ccactggatc agagggcact ccagggctgc 3660
ctggaggagt tggtcagcca ggcgccgtgg gtgagaaggg tgagcgaggg gacgctggag 3720
acccagggcc tccaggagcc ccaggcatcc cggggcccaa gggagacatt ggtgaaaagg 3780
gggactcagg cccatctgga gctgctggac ccccaggcaa gaaaggtccc cctggagagg 3840
atggagccaa agggagcgtg ggccccacgg ggctgcccgg agatctaggg cccccaggag 3900
accctggagt ttcaggcata gatggttccc caggggagaa gggagaccct ggtgatgttg 3960
ggggaccggg tccgcctgga gcttctgggg agcccggcgc ccccgggccc cccggcaaga 4020
ggggtccttc aggccacatg ggtcgagaag gcagagaagg ggagaaaggt gccaaggggg 4080
agccaggtcc tgatgggccc ccagggagga cgggtccaat gggggctaga gggccccctg 4140
gacgtgtggg gcctgagggt cttcgaggga tccctggccc tgtgggtgaa ccaggcctcc 4200
tgggagcccc tggacagatg ggccctcctg gccccctggg gccctctggc ctcccagggc 4260
tgaagggaga cactggcccc aagggggaaa agggccacat tggattgatc ggtctcattg 4320
gccccccggg agaagctggt gagaaaggag atcaggggtt gccaggcgtg cagggacccc 4380
ctggtcccaa gggagaccct ggtccccctg gtcccattgg ctctctgggc caccctgggc 4440
ccccaggtgt ggcgggccct ctaggacaga aaggctcaaa agggtctccg gggtccatgg 4500
gcccccgtgg agacactgga cctgcaggcc caccaggccc cccgggtgcc cctgccgagc 4560
tgcatgggct gcgcaggcgc cggcgcttcg tcccagtccc gcttccagtc gtggagggcg 4620
gcctggagga ggtgctggcc tcgctcacat cgctgagctt ggagctggag cagctgcggc 4680
gtcctcccgg cactgcggag cgcccgggcc tcgtgtgcca cgagctgcac cgcaaccacc 4740
cgcacctgcc tgatggggaa tactggattg accccaacca gggctgcgcg cgggactcgt 4800
tcagggtttt ttgcaacttc acggcgggag gagagacctg cctctatccc gacaagaagt 4860
ttgagatcgt gaaattggcc tcctggtcca aggaaaagcc tggaggctgg tatagcacat 4920
tccgtcgagg gaagaagttc tcctacgtgg acgccgacgg gtccccagtg aatgtcgtgc 4980
agctgaactt cctgaaactg ctgagtgcca cagctcgcca gaacttcacc tactcctgcc 5040
agaatgcagc tgcctggctg gacgaagcca cgggtgacta cagccactcc gcccgcttcc 5100
ttggcaccaa tggagaggag ctgtctttca accagacgac agcagccact gtcagcgtcc 5160
cccaggatgg ctgccggctc cggaaaggac agacgaagac ccttttcgaa ttcagctctt 5220
ctcgagcggg atttctgccc ctgtgggatg tggcggccac tgactttggc cagacgaacc 5280
aaaagtttgg gtttgaactg ggccccgtct gcttcagcag ctgagagtgt ccggggtggg 5340
agggaccatg agggagcccc agaatggggt gcatttggtg ctgaggcttt gaagccaccg 5400
tatttttcgt tacctgtgac tatggagcca atgggatgtg acttcgctca tcacggacag 5460
tcattccttc tcctttccag ggtgctgggg gctggggttc cctggcccaa gggtccagcc 5520
tcctctcacc ccattccagg tggcatactg cagtctggct ctttctcccc tccctcccca 5580
cccaagcctc acctccccac cccttgaacc cccatgcaat gagcttctaa ctcagagctg 5640
atgaacaaaa gcccccccac ccccaatgcc tgcctcctca ctcctccgtc gctgcccttc 5700
acaccttttg gtgctacccc tccccagagt taagcactgg atgtctcctg atcccaggct 5760
gggaccccta cccccacccc ctttgatcct ttctacttcc acggtgaaag gactgaggtc 5820
ggactacaga gggaagaggg acttcccttg actgggttgt gtttcttttc ctgcctcagc 5880
ccagctctgc aaatcccctc cccctgcccc ccacctcccc aggctcacct tgccatgcca 5940
ggtggtttgg ggaccaagat gttggggggg tgaatcagga tcctaatggt gctgccctat 6000
ttatacctgg gtctgtatta aaagggaaag tcccccctgt tgtagatttc atctgcttcc 6060
tccttaggga aggctgggat atgatgagag attccagccc aagcctggcc ccccaccgcc 6120
aggccatagg gcataatttg catctcaaat ctgagaataa actgatgaac tgtgaaaaaa 6180
aaaaaaaaaa aa                                                     6192

<210> 6
<211> 1745
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Asn Arg Arg Asp Leu Gly Gln Pro Arg Ala Gly Leu Cys Leu
 1               5                  10                  15      
Leu Leu Ala Ala Leu Gln Leu Leu Pro Gly Thr Gln Ala Asp Pro Val
            20                  25                  30          
Asp Val Leu Lys Ala Leu Gly Val Gln Gly Gly Gln Ala Gly Val Pro
        35                  40                  45              
Glu Gly Pro Gly Phe Cys Pro Gln Arg Thr Pro Glu Gly Asp Arg Ala
    50                  55                  60                  
Phe Arg Ile Gly Gln Ala Ser Thr Leu Gly Ile Pro Thr Trp Glu Leu
65                  70                  75                  80  
Phe Pro Glu Gly His Phe Pro Glu Asn Phe Ser Leu Leu Ile Thr Leu
                85                  90                  95      
Arg Gly Gln Pro Ala Asn Gln Ser Val Leu Leu Ser Ile Tyr Asp Glu
            100                 105                 110         
Arg Gly Ala Arg Gln Leu Gly Leu Ala Leu Gly Pro Ala Leu Gly Leu
        115                 120                 125             
Leu Gly Asp Pro Phe Arg Pro Leu Pro Gln Gln Val Asn Leu Thr Asp
    130                 135                 140                 
Gly Arg Trp His Arg Val Ala Val Ser Ile Asp Gly Glu Met Val Thr
145                 150                 155                 160 
Leu Val Ala Asp Cys Glu Ala Gln Pro Pro Val Leu Gly His Gly Pro
                165                 170                 175     
Arg Phe Ile Ser Ile Ala Gly Leu Thr Val Leu Gly Thr Gln Asp Leu
            180                 185                 190         
Gly Glu Lys Thr Phe Glu Gly Asp Ile Gln Glu Leu Leu Ile Ser Pro
        195                 200                 205             
Asp Pro Gln Ala Ala Phe Gln Ala Cys Glu Arg Tyr Leu Pro Asp Cys
    210                 215                 220                 
Asp Asn Leu Ala Pro Ala Ala Thr Val Ala Pro Gln Gly Glu Pro Glu
225                 230                 235                 240 
Thr Pro Arg Pro Arg Arg Lys Gly Lys Gly Lys Gly Arg Lys Lys Gly
                245                 250                 255     
Arg Gly Arg Lys Gly Lys Gly Arg Lys Lys Asn Lys Glu Ile Trp Thr
            260                 265                 270         
Ser Ser Pro Pro Pro Asp Ser Ala Glu Asn Gln Thr Ser Thr Asp Ile
        275                 280                 285             
Pro Lys Thr Glu Thr Pro Ala Pro Asn Leu Pro Pro Thr Pro Thr Pro
    290                 295                 300                 
Leu Val Val Thr Ser Thr Val Thr Thr Gly Leu Asn Ala Thr Ile Leu
305                 310                 315                 320 
Glu Arg Ser Leu Asp Pro Asp Ser Gly Thr Glu Leu Gly Thr Leu Glu
                325                 330                 335     
Thr Lys Ala Ala Arg Glu Asp Glu Glu Gly Asp Asp Ser Thr Met Gly
            340                 345                 350         
Pro Asp Phe Arg Ala Ala Glu Tyr Pro Ser Arg Thr Gln Phe Gln Ile
        355                 360                 365             
Phe Pro Gly Ala Gly Glu Lys Gly Ala Lys Gly Glu Pro Ala Val Ile
    370                 375                 380                 
Glu Lys Gly Gln Gln Phe Glu Gly Pro Pro Gly Ala Pro Gly Pro Gln
385                 390                 395                 400 
Gly Val Val Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly
                405                 410                 415     
Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ile Pro Gly Ile
            420                 425                 430         
Asp Gly Ile Arg Gly Pro Pro Gly Thr Val Ile Met Met Pro Phe Gln
        435                 440                 445             
Phe Ala Gly Gly Ser Phe Lys Gly Pro Pro Val Ser Phe Gln Gln Ala
    450                 455                 460                 
Gln Ala Gln Ala Val Leu Gln Gln Thr Gln Leu Ser Met Lys Gly Pro
465                 470                 475                 480 
Pro Gly Pro Val Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Leu Pro
                485                 490                 495     
Gly His Pro Gly Leu Lys Gly Glu Glu Gly Ala Glu Gly Pro Gln Gly
            500                 505                 510         
Pro Arg Gly Leu Gln Gly Pro His Gly Pro Pro Gly Arg Val Gly Lys
        515                 520                 525             
Met Gly Arg Pro Gly Ala Asp Gly Ala Arg Gly Leu Pro Gly Asp Thr
    530                 535                 540                 
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly
545                 550                 555                 560 
Glu Lys Gly Gln Arg Gly Asp Phe Gly His Val Gly Gln Pro Gly Pro
                565                 570                 575     
Pro Gly Glu Asp Gly Glu Arg Gly Ala Glu Gly Pro Pro Gly Pro Thr
            580                 585                 590         
Gly Gln Ala Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly
        595                 600                 605             
Ser Pro Gly Pro Thr Gly Arg Pro Gly Val Thr Gly Ile Asp Gly Ala
    610                 615                 620                 
Pro Gly Ala Lys Gly Asn Val Gly Pro Pro Gly Glu Pro Gly Pro Pro
625                 630                 635                 640 
Gly Gln Gln Gly Asn His Gly Ser Gln Gly Leu Pro Gly Pro Gln Gly
                645                 650                 655     
Leu Ile Gly Thr Pro Gly Glu Lys Gly Pro Pro Gly Asn Pro Gly Ile
            660                 665                 670         
Pro Gly Leu Pro Gly Ser Asp Gly Pro Leu Gly His Pro Gly His Glu
        675                 680                 685             
Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Pro Pro Gly Ser Ala Gly
    690                 695                 700                 
Pro Pro Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Thr Ser Gly Asn
705                 710                 715                 720 
Arg Gly Leu Gln Gly Glu Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro
                725                 730                 735     
Gly Phe Lys Gly Asp Val Gly Leu Lys Gly Asp Gln Gly Lys Pro Gly
            740                 745                 750         
Ala Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Gln
        755                 760                 765             
Ala Gly Gln Ala Gly Glu Glu Gly Pro Pro Gly Ser Ala Gly Glu Lys
    770                 775                 780                 
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Pro Gly
785                 790                 795                 800 
Pro Lys Gly Ser Ile Gly Phe Pro Gly Pro Leu Gly Pro Ile Gly Glu
                805                 810                 815     
Lys Gly Lys Ser Gly Lys Thr Gly Gln Pro Gly Leu Glu Gly Glu Arg
            820                 825                 830         
Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ala Thr Gly
        835                 840                 845             
Gln Pro Gly Pro Lys Gly Asp Val Gly Gln Asp Gly Ala Pro Gly Ile
    850                 855                 860                 
Pro Gly Glu Lys Gly Leu Pro Gly Leu Gln Gly Pro Pro Gly Phe Pro
865                 870                 875                 880 
Gly Pro Lys Gly Pro Pro Gly His Gln Gly Lys Asp Gly Arg Pro Gly
                885                 890                 895     
His Pro Gly Gln Arg Gly Glu Leu Gly Phe Gln Gly Gln Thr Gly Pro
            900                 905                 910         
Pro Gly Pro Ala Gly Val Leu Gly Pro Gln Gly Lys Thr Gly Glu Val
        915                 920                 925             
Gly Pro Leu Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly
    930                 935                 940                 
Glu Gln Gly Leu Pro Gly Leu Glu Gly Arg Glu Gly Ala Lys Gly Glu
945                 950                 955                 960 
Leu Gly Pro Pro Gly Pro Leu Gly Lys Glu Gly Pro Ala Gly Leu Arg
                965                 970                 975     
Gly Phe Pro Gly Pro Lys Gly Gly Pro Gly Asp Pro Gly Pro Thr Gly
            980                 985                 990         
Leu Lys Gly Asp Lys Gly Pro Pro Gly Pro Val Gly Ala Asn Gly Ser
        995                 1000                1005            
Pro Gly Glu Arg Gly Pro Leu Gly Pro Ala Gly Gly Ile Gly Leu Pro
    1010                1015                1020                
Gly Gln Ser Gly Ser Glu Gly Pro Val Gly Pro Ala Gly Lys Lys Gly
1025                1030                1035               1040 
Ser Arg Gly Glu Arg Gly Pro Pro Gly Pro Thr Gly Lys Asp Gly Ile
                1045                1050                1055    
Pro Gly Pro Leu Gly Pro Leu Gly Pro Pro Gly Ala Ala Gly Pro Ser
            1060                1065                1070        
Gly Glu Glu Gly Asp Lys Gly Asp Val Gly Ala Pro Gly His Lys Gly
        1075                1080                1085            
Ser Lys Gly Asp Lys Gly Asp Ala Gly Pro Pro Gly Gln Pro Gly Ile
    1090                1095                1100                
Arg Gly Pro Ala Gly His Pro Gly Pro Pro Gly Ala Asp Gly Ala Gln
1105                1110                1115               1120 
Gly Arg Arg Gly Pro Pro Gly Leu Phe Gly Gln Lys Gly Asp Asp Gly
                1125                1130                1135    
Val Arg Gly Phe Val Gly Val Ile Gly Pro Pro Gly Leu Gln Gly Leu
            1140                1145                1150        
Pro Gly Pro Pro Gly Glu Lys Gly Glu Val Gly Asp Val Gly Ser Met
        1155                1160                1165            
Gly Pro His Gly Ala Pro Gly Pro Arg Gly Pro Gln Gly Pro Thr Gly
    1170                1175                1180                
Ser Glu Gly Thr Pro Gly Leu Pro Gly Gly Val Gly Gln Pro Gly Ala
1185                1190                1195               1200 
Val Gly Glu Lys Gly Glu Arg Gly Asp Ala Gly Asp Pro Gly Pro Pro
                1205                1210                1215    
Gly Ala Pro Gly Ile Pro Gly Pro Lys Gly Asp Ile Gly Glu Lys Gly
            1220                1225                1230        
Asp Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Lys Lys Gly Pro
        1235                1240                1245            
Pro Gly Glu Asp Gly Ala Lys Gly Ser Val Gly Pro Thr Gly Leu Pro
    1250                1255                1260                
Gly Asp Leu Gly Pro Pro Gly Asp Pro Gly Val Ser Gly Ile Asp Gly
1265                1270                1275               1280 
Ser Pro Gly Glu Lys Gly Asp Pro Gly Asp Val Gly Gly Pro Gly Pro
                1285                1290                1295    
Pro Gly Ala Ser Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Lys Arg
            1300                1305                1310        
Gly Pro Ser Gly His Met Gly Arg Glu Gly Arg Glu Gly Glu Lys Gly
        1315                1320                1325            
Ala Lys Gly Glu Pro Gly Pro Asp Gly Pro Pro Gly Arg Thr Gly Pro
    1330                1335                1340                
Met Gly Ala Arg Gly Pro Pro Gly Arg Val Gly Pro Glu Gly Leu Arg
1345                1350                1355               1360 
Gly Ile Pro Gly Pro Val Gly Glu Pro Gly Leu Leu Gly Ala Pro Gly
                1365                1370                1375    
Gln Met Gly Pro Pro Gly Pro Leu Gly Pro Ser Gly Leu Pro Gly Leu
            1380                1385                1390        
Lys Gly Asp Thr Gly Pro Lys Gly Glu Lys Gly His Ile Gly Leu Ile
        1395                1400                1405            
Gly Leu Ile Gly Pro Pro Gly Glu Ala Gly Glu Lys Gly Asp Gln Gly
    1410                1415                1420                
Leu Pro Gly Val Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Pro
1425                1430                1435               1440 
Pro Gly Pro Ile Gly Ser Leu Gly His Pro Gly Pro Pro Gly Val Ala
                1445                1450                1455    
Gly Pro Leu Gly Gln Lys Gly Ser Lys Gly Ser Pro Gly Ser Met Gly
            1460                1465                1470        
Pro Arg Gly Asp Thr Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Ala
        1475                1480                1485            
Pro Ala Glu Leu His Gly Leu Arg Arg Arg Arg Arg Phe Val Pro Val
    1490                1495                1500                
Pro Leu Pro Val Val Glu Gly Gly Leu Glu Glu Val Leu Ala Ser Leu
1505                1510                1515               1520 
Thr Ser Leu Ser Leu Glu Leu Glu Gln Leu Arg Arg Pro Pro Gly Thr
                1525                1530                1535    
Ala Glu Arg Pro Gly Leu Val Cys His Glu Leu His Arg Asn His Pro
            1540                1545                1550        
His Leu Pro Asp Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Ala
        1555                1560                1565            
Arg Asp Ser Phe Arg Val Phe Cys Asn Phe Thr Ala Gly Gly Glu Thr
    1570                1575                1580                
Cys Leu Tyr Pro Asp Lys Lys Phe Glu Ile Val Lys Leu Ala Ser Trp
1585                1590                1595               1600 
Ser Lys Glu Lys Pro Gly Gly Trp Tyr Ser Thr Phe Arg Arg Gly Lys
                1605                1610                1615    
Lys Phe Ser Tyr Val Asp Ala Asp Gly Ser Pro Val Asn Val Val Gln
            1620                1625                1630        
Leu Asn Phe Leu Lys Leu Leu Ser Ala Thr Ala Arg Gln Asn Phe Thr
        1635                1640                1645            
Tyr Ser Cys Gln Asn Ala Ala Ala Trp Leu Asp Glu Ala Thr Gly Asp
    1650                1655                1660                
Tyr Ser His Ser Ala Arg Phe Leu Gly Thr Asn Gly Glu Glu Leu Ser
1665                1670                1675               1680 
Phe Asn Gln Thr Thr Ala Ala Thr Val Ser Val Pro Gln Asp Gly Cys
                1685                1690                1695    
Arg Leu Arg Lys Gly Gln Thr Lys Thr Leu Phe Glu Phe Ser Ser Ser
            1700                1705                1710        
Arg Ala Gly Phe Leu Pro Leu Trp Asp Val Ala Ala Thr Asp Phe Gly
        1715                1720                1725            
Gln Thr Asn Gln Lys Phe Gly Phe Glu Leu Gly Pro Val Cys Phe Ser
    1730                1735                1740                
Ser
1745

