                         SEQUENCE LISTING

<110>  Turner, Andrew
       Sadeghi, Homayoun
 
<120>  Phenylalanine Hydroxylase Fusion Protein and Methods for Treating
       Phenylketonuria

<130>  PHAS-018/02WO

<150>  US 61/247,619
<151>  2009-10-01

<150>  US 61/171,985
<151>  2009-04-23

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  ELP tetratpeptide

<400>  1

Val Pro Gly Gly 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  ELP tetrapeptide

<400>  2

Ile Pro Gly Gly 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any natural or non-natural amino acid residue, and where X 
       optionally varies among 	polymeric or oligomeric repeats

<400>  3

Val Pro Gly Xaa Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide

<400>  4

Ala Val Gly Val Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any natural or non-natural amino acid residue, and where X 
       optionally varies among 	polymeric or oligomeric repeats

<400>  5

Ile Pro Gly Xaa Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide

<400>  6

Ile Pro Gly Val Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any natural or non-natural amino acid residue, and where X 
       optionally varies among 	polymeric or oligomeric repeats

<400>  7

Leu Pro Gly Xaa Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  ELP pentapeptide

<400>  8

Leu Pro Gly Val Gly 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  ELP hexapeptide

<400>  9

Val Ala Pro Gly Val Gly 
1               5       


<210>  10
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  ELP octapeptide

<400>  10

Gly Val Gly Val Pro Gly Val Gly 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  ELP nonapeptide

<400>  11

Val Pro Gly Phe Gly Val Gly Ala Gly 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  ELP nonapeptides

<400>  12

Val Pro Gly Val Gly Val Pro Gly Gly 
1               5                   


<210>  13
<211>  1036
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cdPAH-ELP fusion sequence

<400>  13
gaattctcta gaaataattt tgtttaactt taagaaggag atatacatat gggtgccact       60

gtccatgagc tttcacgaga taagaagaaa gacacagtgc cctggttccc aagaaccatt      120

caagagctgg acagatttgc caatcagatt ctcagctatg gagcggaact ggatgctgac      180

caccctggtt ttaaagatcc tgtgtaccgt gcaagacgga agcagtttgc tgacattgcc      240

tacaactacc gccatgggca gcccatccct cgagtggaat acatggagga agaaaagaaa      300

acatggggca cagtgttcaa gactctgaag tccttgtata aaacccatgc ttgctatgag      360

tacaatcaca tttttccact tcttgaaaag tactgtggct tccatgaaga taacattccc      420

cagctggaag acgtttctca attcctgcag acttgcactg gtttccgcct ccgacctgtg      480

gctggcctgc tttcctctcg ggatttcttg ggtggcctgg ccttccgagt cttccactgc      540

acacagtaca tcagacatgg atccaagccc atgtataccc ccgaacctga catctgccat      600

gagctgttgg gacatgtgcc cttgttttca gatcgcagct ttgcccagtt ttcccaggaa      660

attggccttg cctctctggg tgcacctgat gaatacattg aaaagctcgc cacaatttac      720

tggtttactg tggagtttgg gctctgcaaa caaggagact ccataaaggc atatggtgct      780

gggctcctgt catcctttgg tgaattacag tactgcttat cagagaagcc aaagcttctc      840

cccctggagc tggagaagac agccatccaa aattacactg tcacggagtt ccagcccctg      900

tattacgtgg cagagagttt taatgatgcc aaggagaaag taaggaactt tgctgccaca      960

atacctcggc ccttctcagt tcgctacgac ccatacaccc aaaggattga ggtcttggac     1020

aatacccaag gcgtgg                                                     1036


<210>  14
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cdPAH-ELP fusion sequence

<400>  14

Met Gly Ala Thr Val His Glu Leu Ser Arg Asp Lys Lys Lys Asp Thr 
1               5                   10                  15      


Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu Asp Arg Phe Ala Asn 
            20                  25                  30          


Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp His Pro Gly Phe 
        35                  40                  45              


Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln Phe Ala Asp Ile Ala 
    50                  55                  60                  


Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val Glu Tyr Met Glu 
65                  70                  75                  80  


Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys Thr Leu Lys Ser Leu 
                85                  90                  95      


Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His Ile Phe Pro Leu Leu 
            100                 105                 110         


Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile Pro Gln Leu Glu Asp 
        115                 120                 125             


Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe Arg Leu Arg Pro Val 
    130                 135                 140                 


Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly Gly Leu Ala Phe Arg 
145                 150                 155                 160 


Val Phe His Cys Thr Gln Tyr Ile Arg His Gly Ser Lys Pro Met Tyr 
                165                 170                 175     


Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly His Val Pro Leu 
            180                 185                 190         


Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala 
        195                 200                 205             


Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys Leu Ala Thr Ile Tyr 
    210                 215                 220                 


Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Gly Asp Ser Ile Lys 
225                 230                 235                 240 


Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu Leu Gln Tyr Cys 
                245                 250                 255     


Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu Leu Glu Lys Thr Ala 
            260                 265                 270         


Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro Leu Tyr Tyr Val Ala 
        275                 280                 285             


Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg Asn Phe Ala Ala Thr 
    290                 295                 300                 


Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro Tyr Thr Gln Arg Ile 
305                 310                 315                 320 


Glu Val Leu Asp Asn Thr Gln Gly Val 
                325                 


<210>  15
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0051

<400>  15
gatcgaattc tctagaaata attttgttta actttaagaa ggagatatac atatgggtgc       60

cactgtccat gagctttcac g                                                 81


<210>  16
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0052

<400>  16
tcagccacgc cttgggtatt gtccaagacc tcaatccttt gggtgtatgg                  50


<210>  17
<211>  1006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP-cdPAH fusion sequence

<400>  17
gccgggctgg ccgggtgcca ctgtccatga gctttcacga gataagaaga aagacacagt       60

gccctggttc ccaagaacca ttcaagagct ggacagattt gccaatcaga ttctcagcta      120

tggagcggaa ctggatgctg accaccctgg ttttaaagat cctgtgtacc gtgcaagacg      180

gaagcagttt gctgacattg cctacaacta ccgccatggg cagcccatcc ctcgagtgga      240

atacatggag gaagaaaaga aaacatgggg cacagtgttc aagactctga agtccttgta      300

taaaacccat gcttgctatg agtacaatca catttttcca cttcttgaaa agtactgtgg      360

cttccatgaa gataacattc cccagctgga agacgtttct caattcctgc agacttgcac      420

tggtttccgc ctccgacctg tggctggcct gctttcctct cgggatttct tgggtggcct      480

ggccttccga gtcttccact gcacacagta catcagacat ggatccaagc ccatgtatac      540

ccccgaacct gacatctgcc atgagctgtt gggacatgtg cccttgtttt cagatcgcag      600

ctttgcccag ttttcccagg aaattggcct tgcctctctg ggtgcacctg atgaatacat      660

tgaaaagctc gccacaattt actggtttac tgtggagttt gggctctgca aacaaggaga      720

ctccataaag gcatatggtg ctgggctcct gtcatccttt ggtgaattac agtactgctt      780

atcagagaag ccaaaacttc tccccctgga gctggagaag acagccatcc aaaattacac      840

tgtcacggag ttccagcccc tgtattacgt ggcagagagt tttaatgatg ccaaggagaa      900

agtaaggaac tttgctgcca caatacctcg gcccttctca gttcgctacg acccatacac      960

ccaaaggatt gaggtcttgg acaatacctg ataagctagc aagctt                    1006


<210>  18
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP-cdPAH fusion sequence

<400>  18

Pro Gly Trp Pro Gly Ala Thr Val His Glu Leu Ser Arg Asp Lys Lys 
1               5                   10                  15      


Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu Asp Arg 
            20                  25                  30          


Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp His 
        35                  40                  45              


Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln Phe Ala 
    50                  55                  60                  


Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val Glu 
65                  70                  75                  80  


Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys Thr Leu 
                85                  90                  95      


Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His Ile Phe 
            100                 105                 110         


Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile Pro Gln 
        115                 120                 125             


Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe Arg Leu 
    130                 135                 140                 


Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly Gly Leu 
145                 150                 155                 160 


Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly Ser Lys 
                165                 170                 175     


Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly His 
            180                 185                 190         


Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln Glu Ile 
        195                 200                 205             


Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys Leu Ala 
    210                 215                 220                 


Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Gly Asp 
225                 230                 235                 240 


Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu Leu 
                245                 250                 255     


Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu Leu Glu 
            260                 265                 270         


Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro Leu Tyr 
        275                 280                 285             


Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg Asn Phe 
    290                 295                 300                 


Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro Tyr Thr 
305                 310                 315                 320 


Gln Arg Ile Glu Val Leu Asp Asn Thr 
                325                 


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0053

<400>  19
gtcagccggg ctggccgggt gccactgtcc atgagc                                 36


<210>  20
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0054

<400>  20
gtcaaagctt gctagcttat caggtattgt ccaagacctc                             40


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0055

<400>  21
gagaagccaa aacttctccc                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0056

<400>  22
ggagaagttt tggcttctct g                                                 21


<210>  23
<211>  2680
<212>  DNA
<213>  Homo sapiens

<400>  23
cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct       60

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      120

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      180

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      240

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      300

caagcccacg aggggcgtta ctgtgcggag atgcaccacg caagagacac cctttgtaac      360

tctcttctcc tccctagtgc gaggttaaaa ccttcagccc cacgtgctgt ttgcaaacct      420

gcctgtacct gaggccctaa aaagccagag acctcactcc cggggagcca gcatgtccac      480

tgcggtcctg gaaaacccag gcttgggcag gaaactctct gactttggac aggaaacaag      540

ctatattgaa gacaactgca atcaaaatgg tgccatatca ctgatcttct cactcaaaga      600

agaagttggt gcattggcca aagtattgcg cttatttgag gagaatgatg taaacctgac      660

ccacattgaa tctagacctt ctcgtttaaa gaaagatgag tatgaatttt tcacccattt      720

ggataaacgt agcctgcctg ctctgacaaa catcatcaag atcttgaggc atgacattgg      780

tgccactgtc catgagcttt cacgagataa gaagaaagac acagtgccct ggttcccaag      840

aaccattcaa gagctggaca gatttgccaa tcagattctc agctatggag cggaactgga      900

tgctgaccac cctggtttta aagatcctgt gtaccgtgca agacggaagc agtttgctga      960

cattgcctac aactaccgcc atgggcagcc catccctcga gtggaataca tggaggaaga     1020

aaagaaaaca tggggcacag tgttcaagac tctgaagtcc ttgtataaaa cccatgcttg     1080

ctatgagtac aatcacattt ttccacttct tgaaaagtac tgtggcttcc atgaagataa     1140

cattccccag ctggaagacg tttctcaatt cctgcagact tgcactggtt tccgcctccg     1200

acctgtggct ggcctgcttt cctctcggga tttcttgggt ggcctggcct tccgagtctt     1260

ccactgcaca cagtacatca gacatggatc caagcccatg tatacccccg aacctgacat     1320

ctgccatgag ctgttgggac atgtgccctt gttttcagat cgcagctttg cccagttttc     1380

ccaggaaatt ggccttgcct ctctgggtgc acctgatgaa tacattgaaa agctcgccac     1440

aatttactgg tttactgtgg agtttgggct ctgcaaacaa ggagactcca taaaggcata     1500

tggtgctggg ctcctgtcat cctttggtga attacagtac tgcttatcag agaagccaaa     1560

gcttctcccc ctggagctgg agaagacagc catccaaaat tacactgtca cggagttcca     1620

gcccctgtat tacgtggcag agagttttaa tgatgccaag gagaaagtaa ggaactttgc     1680

tgccacaata cctcggccct tctcagttcg ctacgaccca tacacccaaa ggattgaggt     1740

cttggacaat acccagcagc ttaagatttt ggctgattcc attaacagtg aaattggaat     1800

cctttgcagt gccctccaga aaataaagta aagccatgga cagaatgtgg tctgtcagct     1860

gtgaatctgt tgatggagat ccaactattt ctttcatcag aaaaagtccg aaaagcaaac     1920

cttaatttga aataacagcc ttaaatcctt tacaagatgg agaaacaaca aataagtcaa     1980

aataatctga aatgacagga tatgagtaca tactcaagag cataatggta aatcttttgg     2040

ggtcatcttt gatttagaga tgataatccc atactctcaa ttgagttaaa tcagtaatct     2100

gtcgcatttc atcaagatta attaaaattt gggacctgct tcattcaagc ttcatatatg     2160

ctttgcagag aactcataaa ggagcatata aggctaaatg taaaacacaa gactgtcatt     2220

agaattgaat tattgggctt aatataaatc gtaacctatg aagtttattt tctattttag     2280

ttaactatga ttccaattac tactttgtta ttgtacctaa gtaaattttc tttaggtcag     2340

aagcccatta aaatagttac aagcattgaa cttctttagt attatattaa tataaaaaca     2400

tttttgtatg ttttattgta atcataaata ctgctgtata aggtaataaa actctgcacc     2460

taatccccat aacttccagt atcattttcc aattaattat caagtctgtt ttgggaaaca     2520

ctttgaggac atttatgatg cagcagatgt tgactaaagg cttggttggt agatattcag     2580

gaaatgttca ctgaataaat aagtaaatac attattgaaa agcaaatctg tataaatgtg     2640

aaatttttat ttgtattagt aataaaacat tagtagttta                           2680


<210>  24
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210>  25
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Ala Thr Val His Glu Leu Ser Arg Asp Lys Lys Lys Asp Thr 
1               5                   10                  15      


Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu Asp Arg Phe Ala Asn 
            20                  25                  30          


Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp His Pro Gly Phe 
        35                  40                  45              


Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln Phe Ala Asp Ile Ala 
    50                  55                  60                  


Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val Glu Tyr Met Glu 
65                  70                  75                  80  


Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys Thr Leu Lys Ser Leu 
                85                  90                  95      


Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His Ile Phe Pro Leu Leu 
            100                 105                 110         


Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile Pro Gln Leu Glu Asp 
        115                 120                 125             


Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe Arg Leu Arg Pro Val 
    130                 135                 140                 


Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly Gly Leu Ala Phe Arg 
145                 150                 155                 160 


Val Phe His Cys Thr Gln Tyr Ile Arg His Gly Ser Lys Pro Met Tyr 
                165                 170                 175     


Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly His Val Pro Leu 
            180                 185                 190         


Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala 
        195                 200                 205             


Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys Leu Ala Thr Ile Tyr 
    210                 215                 220                 


Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Gly Asp Ser Ile Lys 
225                 230                 235                 240 


Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu Leu Gln Tyr Cys 
                245                 250                 255     


Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu Leu Glu Lys Thr Ala 
            260                 265                 270         


Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro Leu Tyr Tyr Val Ala 
        275                 280                 285             


Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg Asn Phe Ala Ala Thr 
    290                 295                 300                 


Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro Tyr Thr Gln Arg Ile 
305                 310                 315                 320 


Glu Val Leu Asp Asn Thr Gln 
                325         


<210>  26
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0049

<400>  26
aattctctag aaataatttt gtttaacttt aagaaggaga tatacatatg gttccgggc        59


<210>  27
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer P0050

<400>  27
cggaaccata tgtatatctc cttcttaaag ttaaacaaaa ttatttctag ag               52


<210>  28
<211>  1036
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cdPAH-ELP fusion sequence

<400>  28
gaattctcta gaaataattt tgtttaactt taagaaggag atatacatat gggcgcgacc       60

gtgcatgaac tgagccgtga taagaaaaag gataccgtgc cgtggtttcc gcgtaccatt      120

caggaactgg atcgttttgc gaaccagatt ctgagctatg gcgcggaact ggatgcggat      180

catccgggct ttaaagatcc ggtgtatcgt gcgcgtcgta aacagtttgc ggatattgcg      240

tataactatc gtcatggcca gccgattccg cgtgtggaat atatggaaga agaaaagaaa      300

acctggggca ccgtgtttaa aaccctgaaa agcctgtata aaacccatgc gtgctatgaa      360

tataaccata tttttccgct gctggaaaaa tattgcggct ttcatgaaga taacattccg      420

cagctggaag atgtgagcca gtttctgcag acctgcaccg gttttcgtct gcgtccggtg      480

gcgggcctgc tgagcagccg tgattttctg ggcggcctgg cgtttcgtgt gtttcattgc      540

acccagtata ttcgtcatgg cagcaaaccg atgtataccc cggaaccgga tatttgccat      600

gaactgctgg gccatgtgcc gctgtttagc gatcgcagct ttgcgcagtt tagccaggaa      660

attggcctgg cgagcctggg cgcgccggat gaatatattg aaaaactggc gacgatctac      720

tggtttaccg tggaatttgg cctgtgcaaa cagggcgata gcattaaagc gtatggcgcc      780

ggtctgctga gcagctttgg cgaactgcag tattgcctga gcgaaaaacc gaaactgctg      840

ccgctggaac tggaaaaaac cgcgattcag aactataccg tgaccgaatt tcagccgctg      900

tattatgtgg cggaaagctt taacgatgcg aaagaaaaag tgcgtaactt tgcggcgacc      960

attccgcgtc cgtttagcgt gcgttatgat ccgtataccc agcgtattga agtgctggat     1020

aacacccaag gcgtgg                                                     1036


<210>  29
<211>  1006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP-cdPAH fusion sequence

<400>  29
gccgggctgg ccgggcgcga ccgtgcatga actgagccgt gataagaaaa aggataccgt       60

gccgtggttt ccgcgtacca ttcaggaact ggatcgtttt gcgaaccaga ttctgagcta      120

tggcgcggaa ctggatgcgg atcatccggg ctttaaagat ccggtgtatc gtgcgcgtcg      180

taaacagttt gcggatattg cgtataacta tcgtcatggc cagccgattc cgcgtgtgga      240

atatatggaa gaagaaaaga aaacctgggg caccgtgttt aaaaccctga aaagcctgta      300

taaaacccat gcgtgctatg aatataacca tatttttccg ctgctggaaa aatattgcgg      360

ctttcatgaa gataacattc cgcagctgga agatgtgagc cagtttctgc agacctgcac      420

cggttttcgt ctgcgtccgg tggcgggcct gctgagcagc cgtgattttc tgggcggcct      480

ggcgtttcgt gtgtttcatt gcacccagta tattcgtcat ggcagcaaac cgatgtatac      540

cccggaaccg gatatttgcc atgaactgct gggccatgtg ccgctgttta gcgatcgtag      600

ctttgcgcag tttagccagg aaattggcct ggcgagcctg ggcgcgccgg atgaatatat      660

tgaaaaactg gcgaccattt attggtttac cgtggaattt ggcctgtgca aacagggcga      720

tagcattaaa gcgtatggcg cgggtctgct gtctagcttt ggcgaactgc agtattgcct      780

gagcgaaaaa ccgaaactgc tgccgctgga actggaaaaa accgcgattc agaactatac      840

cgtgaccgaa tttcagccgc tgtattatgt ggcggagagc tttaacgatg cgaaagaaaa      900

agtgcgtaac tttgcggcga ccattccgcg tccgtttagc gtgcgttatg atccgtatac      960

ccagcgtatt gaagtgctgg ataacaccta ataagctagc aagctt                    1006


<210>  30
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP-cdPAH fusion sequence

<400>  30

Ala Gly Leu Ala Gly Ala Thr Val His Glu Leu Ser Arg Asp Lys Lys 
1               5                   10                  15      


Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu Asp Arg 
            20                  25                  30          


Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp His 
        35                  40                  45              


Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln Phe Ala 
    50                  55                  60                  


Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val Glu 
65                  70                  75                  80  


Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys Thr Leu 
                85                  90                  95      


Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His Ile Phe 
            100                 105                 110         


Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile Pro Gln 
        115                 120                 125             


Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe Arg Leu 
    130                 135                 140                 


Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly Gly Leu 
145                 150                 155                 160 


Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly Ser Lys 
                165                 170                 175     


Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly His 
            180                 185                 190         


Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln Glu Ile 
        195                 200                 205             


Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys Leu Ala 
    210                 215                 220                 


Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Gly Asp 
225                 230                 235                 240 


Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu Leu 
                245                 250                 255     


Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu Leu Glu 
            260                 265                 270         


Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro Leu Tyr 
        275                 280                 285             


Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg Asn Phe 
    290                 295                 300                 


Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro Tyr Thr 
305                 310                 315                 320 


Gln Arg Ile Glu Val Leu Asp Asn Thr 
                325                 


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Encoded sequence of pBP1001 modified start sequence

<400>  31

Met Val Pro Gly Val Gly 
1               5       


