                         SEQUENCE LISTING

<110>  U3 Pharma GmbH
 
<120>  Humanized AXL antibodies

<130>  45430P WO

<160>  169   

<170>  PatentIn version 3.3

<210>  1
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Primer EFF1

<400>  1
ccacgcgccc tgtagcggcg cattaagc                                        28


<210>  2
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer EFsmaR

<400>  2
aaacccggga gctttttgca aaagcctagg                                      30


<210>  3
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  3
ggtaccaccc aagctggcta ggtaagcttg ctagcgccac catggtgctg cagacccagg     60

tgttcatctc cctgctgctg tggatctccg gcgcatatgg cgatatcgtg atgattaaac    120

gtacggtggc cgccccctcc gtgttcatct tccccccctc cgacgagcag ctgaagtccg    180

gcaccgcctc cgtggtgtgc ctgctgaata acttctaccc cagagaggcc aaggtgcagt    240

ggaaggtgga caacgccctg cagtccggga actcccagga gagcgtgacc gagcaggaca    300

gcaaggacag cacctacagc ctgagcagca ccctgaccct gagcaaagcc gactacgaga    360

agcacaaggt gtacgcctgc gaggtgaccc accagggcct gagctccccc gtcaccaaga    420

gcttcaacag gggggagtgt taggggcccg tttaaacggg tggcatccct gtgacccctc    480

cccagtgcct ctcctggccc tggaagttgc cactccagtg cccaccagcc ttgtcctaat    540

aaaattaagt tgcatcattt tgtctgacta ggtgtccttc tataatatta tggggtggag    600

gggggtggta tggagcaagg ggcaagttgg gaagacaacc tgtagggcct gcggggtcta    660

ttgggaacca agctggagtg cagtggcaca atcttggctc actgcaatct ccgcctcctg    720

ggttcaagcg attctcctgc ctcagcctcc cgagttgttg ggattccagg catgcatgac    780

caggctcacc taatttttgt ttttttggta gagacggggt ttcaccatat tggccaggct    840

ggtctccaac tcctaatctc aggtgatcta cccaccttgg cctcccaaat tgctgggatt    900

acaggcgtga accactgctc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg    960

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt   1020

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc   1080

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg   1140

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg   1200

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct   1260

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg   1320

agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg   1380

tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc   1440

agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca   1500

tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc   1560

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc   1620

cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct   1680

aggcttttgc aaaaagctcc cggg                                          1704


<210>  4
<211>  1120
<212>  DNA
<213>  Homo sapiens

<400>  4
tgctagcgcc accatgaaac acctgtggtt cttcctcctg ctggtggcag ctcccagatg     60

ggtgctgagc caggtgcaat tgtgcaggcg gttagctcag cctccaccaa gggcccaagc    120

gtcttccccc tggcaccctc ctccaagagc acctctggcg gcacagccgc cctgggctgc    180

ctggtcaagg actacttccc cgaacccgtg accgtgagct ggaactcagg cgccctgacc    240

agcggcgtgc acaccttccc cgctgtcctg cagtcctcag gactctactc cctcagcagc    300

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac    360

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac    420

acatgcccac cctgcccagc acctgaactc ctggggggac cctcagtctt cctcttcccc    480

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    540

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg    600

cataatgcca agacaaagcc ccgggaggag cagtacaaca gcacgtaccg ggtggtcagc    660

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc    720

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg ccagccccgg    780

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc    840

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    900

ggccagcccg agaacaacta caagaccacc cctcccgtgc tggactccga cggctccttc    960

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcagggcaa cgtcttctca   1020

tgctccgtga tgcatgaggc tctgcacaac cactacaccc agaagagcct ctccctgtct   1080

cccggcaaat gagatatcgg gcccgtttaa acgggtggca                         1120


<210>  5
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T1L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  5
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaaccggatc tggcaccgac ttcaccttca ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggcgga    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  6
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T2L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  6
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaaccggatc tggcaccgac tacaccttca ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggcgga    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  7
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T3L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  7
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagccggtc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggcgga    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  8
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T4L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  8
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac ttcaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagc tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  9
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T5L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  9
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagc tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  10
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T6L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  10
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  11
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T7L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  11
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  12
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T8L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  12
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  13
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T9L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  13
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac ttcaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  14
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T10L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  14
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac tacaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  15
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T11L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  15
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggttcca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac ttcaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  16
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T12L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  16
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgat gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac ttcaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  17
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T13L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  17
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaga tgacccagag ccctagctct ctgagcgcct ctgtgggcga ccgggtgacc    120

atcacctgtc gggccagcca ggacatcggc aactacctga gatggtacca gcagaagcct    180

ggaaaggccc ctaagctgct gatcagcggc gccaccaacc tggccgccgg cgtgcctagc    240

cggttctctg gaagcggatc tggcagcgac ttcaccctga ccatcagctc tctgcagcct    300

gaggacttcg ccacctacta ctgtctgcag agcaaggagt ctccttggac cttcggccag    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  18
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T1L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  18

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Thr Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  19
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T2L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  19

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Thr Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  20
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T3L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  20

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  21
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T4L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  21

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  22
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T5L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  22

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  23
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T6L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  23

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  24
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T7L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  24

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  25
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T8L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  25

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  26
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T9L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  26

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  27
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T10L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  27

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  28
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T11L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  28

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  29
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T12L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  29

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Met Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  30
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T13L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  30

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  31
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T1H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  31
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

atccagctgc aggagagcgg ccctggcctg gtgaagccta gccagaccct gagcctgacc    120

tgtgccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat cggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagagtgac catcagcgtg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  32
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T2H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  32
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

atccagctgc aggagagcgg ccctggcctg gtgaagccta gccagaccct gagcctgacc    120

tgtgccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat gggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagaatcag catcagcgtg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  33
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T3H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  33
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc aggagagcgg ccctggcctg gtgaagccta gccagaccct gagcctgacc    120

tgtgccgtgt ctggatacag catcaccagc aactactggg gctggatccg gaagcctcct    180

ggcgacggac tggagtggat gggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagaatcag catcacccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  34
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T4H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  34
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc agcagtgggg cgccggcctg ctgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat cggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagagtgac catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccac cgtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  35
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T5H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  35
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc agcagtgggg cgccggcctg ctgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat gggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagaatcag catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccac cgtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  36
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T6H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  36
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc aggagagcgg ccctggcctg gtgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat gggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagaatcag catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  37
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T7H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  37
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc aggagagcgg ccctggcctg gtgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat cggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagagtgag catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  38
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T8H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  38
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc aggagagcgg ccctggcctg gtgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat gggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagaatcac catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  39
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T9H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  39
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gtgcagctgc aggagagcgg ccctggcctg gtgaagccta gcgagaccct gagcctgacc    120

tgtaccgtgt ctggatacag catcaccagc aactactggg gctggatccg gcagcctcct    180

ggcaagggac tggagtggat cggctacatc acctacagcg gctctaccag ctacaaccct    240

agcctgaagt ctagagtgac catcagccgg gacacctcta agaaccagtt cagcctgaag    300

ctgtcttctg tgaccgccgc cgacaccgcc gtgtactact gtgccatcac caccttctac    360

tactggggac agggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  40
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T1H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  40

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  41
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T2H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  41

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  42
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T3H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  42

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Lys Pro Pro Gly Asp Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  43
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T4H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  43

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  44
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T5H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  44

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  45
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T6H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  45

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  46
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T7H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  46

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  47
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T8H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  47

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  48
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T9H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  48

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  49
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T1L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  49
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacgtgcaaa tgacccagag cccttccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtacca gcaaaagcct    180

ggcaaggccc ctaagcttct gatctacggc gccatcaagc tggccgtggg agtgccttcc    240

cggtttagcg gctccggcag cggcaccgac tttaccctta ccatctccag cctgcagcct    300

gaggactttg ccacctacta ctgtctgcaa tacatccagt ttcctcttac ctttggccaa    360

ggaaccaagc tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  50
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T2L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  50
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaaa tgacccagag cccttccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtttca gcaaaagcct    180

ggcaaggccc ctagacttat gatctacggc gccatcaagc tggccgtggg agtgccttcc    240

cggtttagcg gctccggcag cggcaccgac tacaccctga ccatctccag ccttcagcct    300

gaggactttg ccacctacta ctgtctgcaa tacatccagt ttcctctgac ctttggccaa    360

ggaaccaagc ttgagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  51
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T3L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  51
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaaa tgacccagag cccctccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtttca acagaaggtg    180

ggcaagtccc ctagacggat gatctacggc gccatcaagc ttgccgtggg agtgcctagc    240

agattttccg gcagccggtc cggcagcgac tacaccctga ccatctccag cctgcaacct    300

gaggactttg ccatctacta ctgtcttcag tacatccaat ttcctctgac ctttggctcc    360

ggaaccaagc tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  52
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T4L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  52
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaaa tgacccagag cccttccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtacca gcaaaagcct    180

ggcaaggccc ctaagagact tatctacggc gccatcaagc tggccgtggg agtgccttcc    240

cggtttagcg gctccggcag cggcaccgag tttaccctga ccatctccag ccttcagcct    300

gaggactttg ccacctacta ctgtctgcaa tacatccagt ttcctctgac ctttggcgga    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  53
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T5L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  53
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaaa tgacccagag cccttccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtttca gcaaaagcct    180

ggcaaggccc ctagacggat gatctacggc gccatcaagc ttgccgtggg agtgccttcc    240

agatttagcg gctccggcag cggcaccgac tacaccctga ccatctccag cctgcagcct    300

gaggactttg ccacctacta ctgtcttcaa tacatccagt ttcctctgac ctttggcgga    360

ggcaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  54
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T6L light chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  54
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gacatccaaa tgacccagag cccttccagc ctgtccgcca gcgtgggcga cagagtgacc    120

atcacctgtc gggcctccca agacatcggc aactacctga gctggtttca gcaaaagcct    180

ggcaaggccc ctagacggat gatctacggc gccatcaagc ttgccgtggg agtgccttcc    240

agatttagcg gctccggcag cggcaccgac tacaccctga ccatctccag cctgcagcct    300

gaggactttg ccacctacta ctgtcttcaa tacatccagt ttcctctgac ctttggccaa    360

ggaaccaagg tggagatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  55
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T1L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  55

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  56
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T2L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  56

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Arg Leu Met Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  57
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T3L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  57

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Phe Gln Gln Lys Val Gly Lys Ser Pro 
    50                  55                  60                  


Arg Arg Met Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  58
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T4L light chain(AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  58

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  59
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T5L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  59

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Arg Arg Met Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  60
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T6L light chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  60

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Arg Arg Met Ile Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile 
            100                 105                 110         


Gln Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  61
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T1H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  61
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccaa     60

gtgcaactgc aagagagcgg ccctggcctg gtgaagcctt cccaaaccct tagcctgacc    120

tgtaccgtga gcggctactc catcaccagc aactactggg gctggatcag acaacctcct    180

ggcatgggcc tggagtggat cggacacatc accaatagcg gcaacaccac ctacaatccc    240

tcccttaaga gccgggtgac catctccgtg gacaccagcg agaaccaatt ttccctgaag    300

ctgtcttccg tgacccctgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct tgtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  62
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T2H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  62
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagcgag     60

gtgcaactgc aagagagcgg ccctggcctg gtgaagcctt cccaaaccct tagcctgacc    120

tgtaccgtgt ccggctacag catcacctcc aactactggg gctggatcag acaacctcct    180

ggcatgggcc tggagtggat cggacacatc accaatagcg gcaacaccac ctacaatccc    240

tcccttaaga gccggatctc catcagcgtg gacacctccg agaaccaatt tagcctgaag    300

ctgtccagcg tgacccctgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct tgtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  63
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T3H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  63
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagcgag     60

gtgcaactgc aagagagcgg ccctggcctg gtgaagcctt cccaaaccct tagcctgacc    120

tgtaccgtgt ccggctacag catcacctcc aactactggg gctggatcag aaagtttcct    180

ggcaacaaga tggagtggat cggacacatc accaatagcg gcaacaccac ctacaatccc    240

tccctgaaga gccggatctc catcagccgg gacacctcca agaaccaatt tagccttaag    300

ctgtccagcg tgacccctgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  64
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T4H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  64
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccaa     60

gtgcaactgc aacaatgggg cgccggcctg cttaagccta gcgagaccct gtccctgacc    120

tgtaccgtga gcggctactc catcaccagc aactactggg gctggatcag acaacctcct    180

ggcaagggcc ttgagtggat cggacacatc accaattccg gcaacaccac ctacaatccc    240

agcctgaagt cccgggtgac catcagcaga gacacctcca agaaccaatt tagcctgaag    300

ctttccagcg tgaccgccgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  65
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T5H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  65
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagcgag     60

gtgcaactgc aacaatgggg cgccggcctg cttaagccta gcgagaccct gtccctgacc    120

tgtaccgtga gcggctactc catcaccagc aactactggg gctggatcag acaacctcct    180

ggcaagggcc ttgagtggat cggacacatc accaattccg gcaacaccac ctacaatccc    240

agcctgaagt cccggatcag catctccaga gacaccagca agaaccaatt ttccctgaag    300

ctttccagcg tgaccgccgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct ggtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  66
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11D5-T6H heavy chain (DNA)


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (297)..(1386)

<400>  66
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagcgag     60

gtgcaactgc aagagagcgg ccctggcctg gtgaagcctt ccgagaccct tagcctgacc    120

tgtaccgtgt ccggctacag catcacctcc aactactggg gctggatcag acaacctcct    180

ggcaagggcc tggagtggat cggacacatc accaatagcg gcaacaccac ctacaatccc    240

tcccttaaga gccggatctc catcagcaga gacacctcca agaaccaatt tagcctgaag    300

ctgtccagcg tgaccgccgc cgacaccgcc gtgtactact gtgccaaggg cgcctttgac    360

tactggggcc aaggaaccct tgtgaccgtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  67
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T1H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  67

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Met Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Glu Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Pro Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  68
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T2H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  68

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Met Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Val Asp Thr Ser Glu Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Pro Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  69
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T3H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  69

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asn Lys Met 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Pro Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  70
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T4H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  70

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  71
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T5H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  71

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  72
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T6H heavy chain (AA)


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  72

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  73
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T14L light chain variable region (AA)

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  74
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T15L light chain variable region (AA)

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  75
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T16L light chain variable region (AA)

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  76
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T17L light chain variable region (AA)

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  77
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T18L light chain variable region (AA)

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  78
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T19L light chain variable region (AA)

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  79
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T20L light chain variable region (AA)

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  80
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T10H heavy chain variable region (AA)

<400>  80

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  81
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T11H heavy chain variable region (AA)

<400>  81

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  82
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>   h#11B7-T12H heavy chain variable region (AA)

<400>  82

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  83
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T7L light chain variable region (AA)

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  84
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T8L light chain variable region (AA)

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  85
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T9L light chain variable region (AA)

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  86
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T10L light chain variable region (AA)

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  87
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T11L light chain variable region (AA)

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  88
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T12L light chain variable region (AA)

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  89
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T13L light chain variable region (AA)

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  90
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T14L light chain variable region (AA)

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  91
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T15L light chain variable region (AA)

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  92
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T16L light chain variable reigon (AA)

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  93
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T17L light chain variable region (AA)

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  94
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T18L light chain variable region (AA)

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  95
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T19L light chain variable region (AA)

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  96
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T20L light chain variable region (AA)

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  97
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T21L light chain variable region (AA)

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  98
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T22L light chain variable region (AA)

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  99
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T23L light chain variable region (AA)

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  100
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T24L light chain variable region (AA)

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  101
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T25L light chain variable region (AA)

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  102
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T26L light chain variable region (AA)

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  103
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T27L light chain variable region (AA)

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  104
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T28L light chain variable region(AA)

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  105
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T29L light chain variable region(AA)

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  106
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T30L light chain variable region (AA)

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  107
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T31L light chain variable region(AA)

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  108
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T32L light chain variablre region(AA)

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  109
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T33L light chain variable region (AA)

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  110
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T34L light chain variable region (AA)

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  111
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T35L light chain variable region (AA)

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  112
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T36L light chain variable region (AA)

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  113
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T37L light chain variable region (AA)

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  114
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T7H heavy chain variable region (AA)

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  115
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T8H heavy chain variable region (AA)

<400>  115

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  116
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T9H heavy chain variable region (AA)

<400>  116

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  117
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T10H heavy chain variable region (AA)

<400>  117

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  118
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T11H heavy chain variable region(AA)

<400>  118

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  119
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T12H heavy chain variable region (AA)

<400>  119

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  120
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  h#11D5-T13H heavy chain variable region (AA)

<400>  120

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  121
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Light chain CDRL4

<400>  121

Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Arg 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Light chain CDRL5

<400>  122

Gly Ala Thr Asn Leu Ala Ala 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Light chain CDRL6

<400>  123

Leu Gln Ser Lys Glu Ser Pro Trp Thr 
1               5                   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Heavy chain CDRH1

<400>  124

Ser Asn Tyr Trp Gly 
1               5   


<210>  125
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Heavy chain CDRH2

<400>  125

Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  126
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 Heavy chain CDRH3

<400>  126

Thr Thr Phe Tyr Tyr 
1               5   


<210>  127
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRL4

<400>  127

Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Ser 
1               5                   10      


<210>  128
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRL5

<400>  128

Gly Ala Ile Lys Leu Ala Val 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRL6

<400>  129

Leu Gln Tyr Ile Gln Phe Pro Leu Thr 
1               5                   


<210>  130
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRH1

<400>  130

Ser Asn Tyr Trp Gly 
1               5   


<210>  131
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRH2

<400>  131

His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  132
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 Light chain CDRH3

<400>  132

Gly Ala Phe Asp Tyr 
1               5   


<210>  133
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Leader Sequence (nucleotide sequence)

<400>  133
atgggtgaca atgacatcca ctttgccttt ctctccacag gtgtgcattc c              51


<210>  134
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Leader Sequence (amino acid sequence)

<400>  134

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Val His 
1               5                   10                  15      


Ser 
    


<210>  135
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>   #11B7-chimeric light chain

<400>  135

Asp Ile Gln Met Thr Gln Ala Pro Ser Ser Leu Pro Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Arg Leu Met Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Met Ala Asp Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  136
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  #11B7-chimeric heavy chain

<400>  136

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asp Lys Met Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  137
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  #11D5-chimeric light chain

<400>  137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Val Gly Lys Ser Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Met Ala Ile Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  138
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  #11D5-chimeric heavy chain

<400>  138

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Arg Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  139
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Gly Trp Ala 
1               5                   10                  15      


Cys Met Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val Gly 
            20                  25                  30          


Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu Arg 
        35                  40                  45              


Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu Arg 
    50                  55                  60                  


Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro 
65                  70                  75                  80  


Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu Arg 
                85                  90                  95      


Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu Val 
            100                 105                 110         


Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu 
        115                 120                 125             


Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala 
    130                 135                 140                 


Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu 
145                 150                 155                 160 


Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala 
                165                 170                 175     


Pro Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys 
            180                 185                 190         


Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr 
        195                 200                 205             


Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn Leu 
    210                 215                 220                 


His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro 
225                 230                 235                 240 


Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala Val 
                245                 250                 255     


Leu Ser Asp Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro 
            260                 265                 270         


Glu Glu Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg 
        275                 280                 285             


Leu Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys 
    290                 295                 300                 


Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val Glu 
305                 310                 315                 320 


Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr 
                325                 330                 335     


Arg Asn Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro 
            340                 345                 350         


Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp 
        355                 360                 365             


Thr Pro Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu 
    370                 375                 380                 


Glu Leu Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala 
385                 390                 395                 400 


Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu 
                405                 410                 415     


Glu Ala Trp Arg Pro Gly Glu Ala Gln Pro Val His Gln Leu Val Lys 
            420                 425                 430         


Glu Pro Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu 
        435                 440                 445             


Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu 
    450                 455                 460                 


Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
465                 470                 475                 480 


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
                485                 490                 495     


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
            500                 505                 510         


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
        515                 520                 525             


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
    530                 535                 540                 


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
545                 550                 555                 560 


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
                565                 570                 575     


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
            580                 585                 590         


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
        595                 600                 605             


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
    610                 615                 620                 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
625                 630                 635                 640 


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
                645                 650                 655     


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
            660                 665                 670         


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
        675                 680                 685             


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
    690                 695                 700                 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
705                 710                 715                 720 


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
                725                 730                 735     


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
            740                 745                 750         


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
        755                 760                 765             


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
    770                 775                 780                 


Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
785                 790                 795                 800 


Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn 
                805                 810                 815     


Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly 
            820                 825                 830         


Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu 
        835                 840                 845             


Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser 
    850                 855                 860                 


Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala 
865                 870                 875                 880 


Pro Gly Gln Glu Asp Gly Ala 
                885         


<210>  140
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 light chain variable region

<400>  140

Asp Ile Gln Met Thr Gln Ala Pro Ser Ser Leu Pro Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Arg Leu Met Ile 
        35                  40                  45              


Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Met Ala Asp Tyr Tyr Cys Leu Gln Ser Lys Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  141
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  11B7 heavy chain variable region

<400>  141

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asp Lys Met Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  142
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 light chain variable region

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Val Gly Lys Ser Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Met Ala Ile Tyr Tyr Cys Leu Gln Tyr Ile Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  143
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  11D5 heavy chain variable region

<400>  143

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Ile 
        35                  40                  45              


Gly His Ile Thr Asn Ser Gly Asn Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Arg Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Ala Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  144
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T15L light chain


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  144
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gatatccaga tgacccagtc accctccagt ctcagtgcga gcgtcggcga tcgggtgaca    120

atcacatgta gggcatctca ggatatcggg aattacctta ggtggttcca gcaaaagccc    180

ggaaaagctc ccaaactgtt gatttctggg gccaccaatc ttgccgcagg ggtgccctca    240

aggttctccg ggtccggcag cggatccgat tataccttga caatttctag tttgcagcct    300

gaggatttcg caacttacta ctgtcttcag agcaaggaat ctccatggac cttcggacag    360

gggactaaac tcgaaatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  145
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T18L light chain


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  signal sequence

<220>
<221>  V_region
<222>  (61)..(387)

<220>
<221>  C_region
<222>  (388)..(702)

<400>  145
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcatatggc     60

gatattcaga tgacacagag cccatcctcc cttagcgcat ccgttgggga tagagttacc    120

attacctgca gagccagcca ggacatcggc aactacctgc gctggttcca gcagaagcct    180

ggcaaagcgc ccaaactgct tatcagcgga gccacaaacc tggccgccgg tgtgccctct    240

cggttcagcg ggtctggcag cgggagcgat ttcactctta caatatcttc ccttcagccc    300

gaagatttcg cgacatatta ctgcttgcaa tccaaggaaa gtccctggac attcggccaa    360

ggaactaaac tggaaattaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc    420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac    480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag    540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc    600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                       702


<210>  146
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T15L light chain


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  146

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  147
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T18L light chain


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (21)..(129)
<223>  variable region

<220>
<221>  SITE
<222>  (130)..(234)
<223>  constant region

<400>  147

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Asn Tyr Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  148
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T11H heavy chain


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  148
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gttcaactgc agcagtgggg tgctggtctg ttgaagccaa gtgaaacctt gtctctgacc    120

tgcacagtca gcggatatag tattacatct aactactggg gctggatcag acagccccct    180

ggcaaggggc tggagtggat ggggtatatt acgtattctg ggtcaacatc ttataatccc    240

tccctgaagt cccgcattac catcagccgc gacacttcca agaaccagtt ttcacttaag    300

ctgtctagcg taacagccgc ggacactgca gtgtattatt gcgctattac cactttctat    360

tattgggggc agggcacgac ggtaacggtg agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  149
<211>  1386
<212>  DNA
<213>  Artificial

<220>
<223>  h#11B7-T12H heavy chain


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  signal sequence

<220>
<221>  V_region
<222>  (58)..(396)

<220>
<221>  C_region
<222>  (397)..(1386)

<400>  149
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag     60

gttcagctgc aacagtgggg agctgggttg ctgaagccaa gtgaaaccct gtcccttaca    120

tgtaccgtct ctggttacag tattacctcc aactactggg ggtggatcag acagcctcca    180

ggtaaagggc tggagtggat aggatatatt acctattccg gctccacgtc ttataatcca    240

tccctgaaat ctagggtgac catctctagg gacacttcaa aaaatcaatt tagcctcaaa    300

ctttcttctg tcacagccgc cgataccgct gtctactact gtgcgatcac cacattttac    360

tattggggcc aggggacaac agtgaccgtt agctcagcct ccaccaaggg cccaagcgtc    420

ttccccctgg caccctcctc caagagcacc tctggcggca cagccgccct gggctgcctg    480

gtcaaggact acttccccga acccgtgacc gtgagctgga actcaggcgc cctgaccagc    540

ggcgtgcaca ccttccccgc tgtcctgcag tcctcaggac tctactccct cagcagcgtg    600

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag    660

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca    720

tgcccaccct gcccagcacc tgaactcctg gggggaccct cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac    840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccccg ggaggagcag tacaacagca cgtaccgggt ggtcagcgtc    960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac   1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaaggcca gccccgggaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggc   1200

cagcccgaga acaactacaa gaccacccct cccgtgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc agggcaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacccaga agagcctctc cctgtctccc   1380

ggcaaa                                                              1386


<210>  150
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T11H heavy chain


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  150

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  151
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  h#11B7-T12H heavy chain


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (20)..(132)
<223>  variable region

<220>
<221>  SITE
<222>  (133)..(462)
<223>  constant region

<400>  151

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ile Thr Thr Phe Tyr Tyr Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  152
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer kappa_GSP1

<400>  152
gatggatgca ttggtgcagc                                                 20


<210>  153
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer new_kappa_GSP1

<400>  153
atagatacag ttggtgcagc                                                 20


<210>  154
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer heavy_GSP1

<400>  154
cagggtcacc atggagtta                                                  19


<210>  155
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Xhol-hGSP2

<400>  155
ccgctcgagc gggccagtgg atagacagat gg                                   32


<210>  156
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Xhol-kGSP2

<400>  156
ccgctcgagc ggccgtttca gctccagctt gg                                   32


<210>  157
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT-gamma

<400>  157
gcgtgtagtg gttgtgcaga g                                               21


<210>  158
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT-gamma2

<400>  158
gggcttgccg gccgtg                                                     16


<210>  159
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT-kappa

<400>  159
tggaactgag gagcaggtgg                                                 20


<210>  160
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 5'Blp

<400>  160
agataagctt tgctcagcgt ccaccaaggg cccatcggt                            39


<210>  161
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 3'Bam(GAG)

<400>  161
agatggatcc tcatttaccc ggagacaggg agag                                 34


<210>  162
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 5'Bsi

<400>  162
agataagctt cgtacggtgg ctgcaccatc tgtcttcat                            39


<210>  163
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 3'Bam (CTT)

<400>  163
agatggatcc ctaacactct cccctgttga agctct                               36


<210>  164
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VL-11B7-5'

<400>  164
agataagctt gtgcattccg acatccagat gacccaggct cc                        42


<210>  165
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VL-11B7-3'

<400>  165
agatcgtacg tttcagctcc agcttggtgc ctc                                  33


<210>  166
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VL-11D5-5'

<400>  166
agataagctt gtgcattccg acatccagat gacccagtct ccatc                     45


<210>  167
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VL-11D5-3'

<400>  167
agatcgtacg tttcagcttg gtcccag                                         27


<210>  168
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VH-11b7/11D5-5'

<400>  168
agataagctt gtgcattccg aggtgcagct tcaggagtca gg                        42


<210>  169
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer VH-11B7/11D5-3'

<400>  169
agatgctgag ctgacagtga ccatgactcc ttggcc                               36


