                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  Anticorps humaniss spcifiques de la forme protofibrillaire du 
       peptide bta-amylode

<130>  FR2009-054

<160>  32    

<170>  PatentIn version 3.3

<210>  1
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  1
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  2
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  3
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(660)

<400>  3
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag      384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu         
        115                 120                 125                     

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc      432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe         
    130                 135                 140                         

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa      480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln         
145                 150                 155                 160         

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc      528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser         
                165                 170                 175             

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag      576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu         
            180                 185                 190                 

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg      624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser         
        195                 200                 205                     

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                      660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                             
    210                 215                                             


<210>  4
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(345)

<400>  5
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc                                                          345
Val Ser Ser                                                             
        115                                                             


<210>  6
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(339)

<400>  7
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt                                                                  339
Arg                                                                     
                                                                        


<210>  8
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  9
<211>  33
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(33)

<400>  9
tcc ggc tac aca ttc act gat tat gct atg cac                           33
Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His                             
1               5                   10                                  


<210>  10
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  10

Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10      


<210>  11
<211>  30
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(30)

<400>  11
gtt att agt act aag tat ggt aag aca aac                               30
Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn                                 
1               5                   10                                  


<210>  12
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  12

Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn 
1               5                   10  


<210>  13
<211>  18
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(18)

<400>  13
ggg gac gat ggt tat tcc                                               18
Gly Asp Asp Gly Tyr Ser                                                 
1               5                                                       


<210>  14
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  14

Gly Asp Asp Gly Tyr Ser 
1               5       


<210>  15
<211>  48
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(48)

<400>  15
aga tct ggt cag agc ctt gtg cac agt aat gga aac acc tat ctg cat       48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His         
1               5                   10                  15              


<210>  16
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  16

Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  17
<211>  24
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(24)

<400>  17
aca gtt tcc aac cga ttt tct ggg                                       24
Thr Val Ser Asn Arg Phe Ser Gly                                         
1               5                                                       


<210>  18
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  18

Thr Val Ser Asn Arg Phe Ser Gly 
1               5               


<210>  19
<211>  27
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(27)

<400>  19
tct caa aat aca ttt gtt cct tgg acg                                   27
Ser Gln Asn Thr Phe Val Pro Trp Thr                                     
1               5                                                       


<210>  20
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  20

Ser Gln Asn Thr Phe Val Pro Trp Thr 
1               5                   


<210>  21
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(660)

<400>  21
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag      384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu         
        115                 120                 125                     

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc      432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe         
    130                 135                 140                         

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa      480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln         
145                 150                 155                 160         

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc      528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser         
                165                 170                 175             

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag      576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu         
            180                 185                 190                 

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg      624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser         
        195                 200                 205                     

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                      660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                             
    210                 215                                             


<210>  22
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(339)

<400>  23
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt                                                                  339
Arg                                                                     
                                                                        


<210>  24
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  25
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  25
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  26
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  27
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(345)

<400>  27
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc                                                          345
Val Ser Ser                                                             
        115                                                             


<210>  28
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  29
<211>  18
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(18)

<400>  29
ggg gac gag ggt tat tcc                                               18
Gly Asp Glu Gly Tyr Ser                                                 
1               5                                                       


<210>  30
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  30

Gly Asp Glu Gly Tyr Ser 
1               5       


<210>  31
<211>  48
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(48)

<400>  31
aga tct ggt cag agc ctt gtg cac agt aat acc aac acc tat ctg cat       48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His         
1               5                   10                  15              


<210>  32
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  32

Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His 
1               5                   10                  15      


