                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Dewji, Nazneen
       Singer, S. Jonathan
 
<120>  METHODS AND COMPOSITIONS FOR TREATING NEURODEGEERATIVE DISORDES 
       AND ALZHEIMER'S DISEASE AND IMPROVING NORMAL MEMORY

<130>  00015-027WO2

<140>  Not yet known
<141>  2010-05-12


<150>  US 12/464,850
<151>  2009-05-12

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1404
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1404)

<400>  1
atg aca gag tta cct gca ccg ttg tcc tac ttc cag aat gca cag atg         48
Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met           
1               5                   10                  15                

tct gag gac aac cac ctg agc aat act gta cgt agc cag aat gac aat         96
Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn           
            20                  25                  30                    

aga gaa cgg cag gag cac aac gac aga cgg agc ctt ggc cac cct gag        144
Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu           
        35                  40                  45                        

cca tta tct aat gga cga ccc cag ggt aac tcc cgg cag gtg gtg gag        192
Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu           
    50                  55                  60                            

caa gat gag gaa gaa gat gag gag ctg aca ttg aaa tat ggc gcc aag        240
Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys           
65                  70                  75                  80            

cat gtg atc atg ctc ttt gtc cct gtg act ctc tgc atg gtg gtg gtc        288
His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val           
                85                  90                  95                

gtg gct acc att aag tca gtc agc ttt tat acc cgg aag gat ggg cag        336
Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln           
            100                 105                 110                   

cta atc tat acc cca ttc aca gaa gat acc gag act gtg ggc cag aga        384
Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg           
        115                 120                 125                       

gcc ctg cac tca att ctg aat gct gcc atc atg atc agt gtc att gtt        432
Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val           
    130                 135                 140                           

gtc atg act atc ctc ctg gtg gtt ctg tat aaa tac agg tgc tat aag        480
Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys           
145                 150                 155                 160           

gtc atc cat gcc tgg ctt att ata tca tct cta ttg ttg ctg ttc ttt        528
Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe           
                165                 170                 175               

ttt tca ttc att tac ttg ggg gaa gtg ttt aaa acc tat aac gtt gct        576
Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala           
            180                 185                 190                   

gtg gac tac att act gtt gca ctc ctg atc tgg aat ttt ggt gtg gtg        624
Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val           
        195                 200                 205                       

gga atg att tcc att cac tgg aaa ggt cca ctt cga ctc cag cag gca        672
Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala           
    210                 215                 220                           

tat ctc att atg att agt gcc ctc atg gcc ctg gtg ttt atc aag tac        720
Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr           
225                 230                 235                 240           

ctc cct gaa tgg act gcg tgg ctc atc ttg gct gtg att tca gta tat        768
Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr           
                245                 250                 255               

gat tta gtg gct gtt ttg tgt ccg aaa ggt cca ctt cgt atg ctg gtt        816
Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val           
            260                 265                 270                   

gaa aca gct cag gag aga aat gaa acg ctt ttt cca gct ctc att tac        864
Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr           
        275                 280                 285                       

tcc tca aca atg gtg tgg ttg gtg aat atg gca gaa gga gac ccg gaa        912
Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu           
    290                 295                 300                           

gct caa agg aga gta tcc aaa aat tcc aag tat aat gca gaa agc aca        960
Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr           
305                 310                 315                 320           

gaa agg gag tca caa gac act gtt gca gag aat gat gat ggc ggg ttc       1008
Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe           
                325                 330                 335               

agt gag gaa tgg gaa gcc cag agg gac agt cat cta ggg cct cat cgc       1056
Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg           
            340                 345                 350                   

tct aca cct gag tca cga gct gct gtc cag gaa ctt tcc agc agt atc       1104
Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile           
        355                 360                 365                       

ctc gct ggt gaa gac cca gag gaa agg gga gta aaa ctt gga ttg gga       1152
Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly           
    370                 375                 380                           

gat ttc att ttc tac agt gtt ctg gtt ggt aaa gcc tca gca aca gcc       1200
Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala           
385                 390                 395                 400           

agt gga gac tgg aac aca acc ata gcc tgt ttc gta gcc ata tta att       1248
Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile           
                405                 410                 415               

ggt ttg tgc ctt aca tta tta ctc ctt gcc att ttc aag aaa gca ttg       1296
Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu           
            420                 425                 430                   

cca gct ctt cca atc tcc atc acc ttt ggg ctt gtt ttc tac ttt gcc       1344
Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala           
        435                 440                 445                       

aca gat tat ctt gta cag cct ttt atg gac caa tta gca ttc cat caa       1392
Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln           
    450                 455                 460                           

ttt tat atc tag                                                       1404
Phe Tyr Ile                                                               
465                                                                       


<210>  2
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  3
<211>  1347
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1347)

<400>  3
atg ctc aca ttc atg gcc tct gac agc gag gaa gaa gtg tgt gat gag         48
Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu           
1               5                   10                  15                

cgg acg tcc cta atg tcg gct gag agc ccc acg ccg cgc tcc tgc cag         96
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln           
            20                  25                  30                    

gag ggc agg cag ggc cca gag gat gga gag aac act gcc cag tgg aga        144
Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg           
        35                  40                  45                        

agc cag gag aac gag gag gac ggt gag gag gac cct gac cgc tat gtc        192
Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val           
    50                  55                  60                            

tgt agt ggg gtt ccc ggg cgg ccg cca ggc ctg gag gaa gag ctg acc        240
Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr           
65                  70                  75                  80            

ctc aaa tac gga gcg aag cac gtg atc atg ctg ttt gtg cct gtc act        288
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr           
                85                  90                  95                

ctg tgc atg atc gtg gtg gta gcc acc atc aag tct gtg cgc ttc tac        336
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr           
            100                 105                 110                   

aca gag aag aat gga cag ctc atc tac acg cca ttc act gag gac aca        384
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr           
        115                 120                 125                       

ccc tcg gtg ggc cag cgc ctc ctc aac tcc gtg ctg aac acc ctc atc        432
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile           
    130                 135                 140                           

atg atc agc gtc atc gtg gtt atg acc atc ttc ttg gtg gtg ctc tac        480
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr           
145                 150                 155                 160           

aag tac cgc tgc tac aag ttc atc cat ggc tgg ttg atc atg tct tca        528
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser           
                165                 170                 175               

ctg atg ctg ctg ttc ctc ttc acc tat atc tac ctt ggg gaa gtg ctc        576
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu           
            180                 185                 190                   

aag acc tac aat gtg gcc atg gac tac ccc acc ctc ttg ctg act gtc        624
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val           
        195                 200                 205                       

tgg aac ttc ggg gca gtg ggc atg gtg tgc atc cac tgg aag ggc cct        672
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro           
    210                 215                 220                           

ctg gtg ctg cag cag gcc tac ctc atc atg atc agt gcg ctc atg gcc        720
Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala           
225                 230                 235                 240           

cta gtg ttc atc aag tac ctc cca gag tgg tcc gcg tgg gtc atc ctg        768
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu           
                245                 250                 255               

ggc gcc atc tct gtg tat gat ctc gtg gct gtg ctg tgt ccc aaa ggg        816
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly           
            260                 265                 270                   

cct ctg aga atg ctg gta gaa act gcc cag gag aga aat gag ccc ata        864
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile           
        275                 280                 285                       

ttc cct gcc ctg ata tac tca tct gcc atg gtg tgg acg gtt ggc atg        912
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met           
    290                 295                 300                           

gcg aag ctg gac ccc tcc tct cag ggt gcc ctc cag ctc ccc tac gac        960
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp           
305                 310                 315                 320           

ccg gag atg gaa gaa gac tcc tat gac agt ttt ggg gag cct tca tac       1008
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr           
                325                 330                 335               

ccc gaa gtc ttt gag cct ccc ttg act ggc tac cca ggg gag gag ctg       1056
Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu           
            340                 345                 350                   

gag gaa gag gag gaa agg ggc gtg aag ctt ggc ctc ggg gac ttc atc       1104
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile           
        355                 360                 365                       

ttc tac agt gtg ctg gtg ggc aag gcg gct gcc acg ggc agc ggg gac       1152
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp           
    370                 375                 380                           

tgg aat acc acg ctg gcc tgc ttc gtg gcc atc ctc att ggc ttg tgt       1200
Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys           
385                 390                 395                 400           

ctg acc ctc ctg ctg ctt gct gtg ttc aag aag gcg ctg ccc gcc ctc       1248
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu           
                405                 410                 415               

ccc atc tcc atc acg ttc ggg ctc atc ttt tac ttc tcc acg gac aac       1296
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn           
            420                 425                 430                   

ctg gtg cgg ccg ttc atg gac acc ctg gcc tcc cat cag ctc tac atc       1344
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile           
        435                 440                 445                       

tga                                                                   1347


<210>  4
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  5

Asp Glu Glu Glu Asp Glu Glu Leu 
1               5               


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  6

Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn Gly Arg Pro 
1               5                   10                  15  


<210>  7
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  7

Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn Gly Arg Pro Gln 
1               5                   10                  15      


Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu Glu Asp Glu Glu 
            20                  25                  30          


Leu Thr Leu Lys Tyr Gly Ala Lys 
        35                  40  


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  8

Lys Lys Ala Leu Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val 
1               5                   10                  15      


Phe Tyr Phe Ala 
            20  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  9

Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu 
1               5                   10      


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence for SH3 binding


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  10

Pro Xaa Xaa Pro 
1               


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for SH3 binding


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Arg or a hydrophobic residue

<400>  11

Arg Xaa Leu Pro Xaa Xaa Pro 
1               5           


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Src peptide substrate

<400>  12

Lys Val Glu Lys Ile Gly Thr Tyr Gly Val Val Lys Lys 
1               5                   10              


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control peptide for Src assay

<400>  13

Lys Val Glu Lys Ile Gly Val Gly Ser Tyr Gly Val Val Lys Lys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control peptide for Src assay

<400>  14

Lys Val Glu Lys Ile Gly Glu Gly Thr Phe Gly Val Val Lys Lys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  15

Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  16

Arg Gln Val Val Glu Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Fragment of Presenilin

<400>  17

Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
1               5                   10                  15  


