                         SEQUENCE LISTING

<110>  Mei, Lin
       Xiong, Wen-cheng
       Tao, Yanmei
 
<120>  Methods and Compositions for Modulating Erbb2 Activity

<130>  MCG 2009-034

<150>  US 61/216,218
<151>  2009-05-14

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1371
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Thr Lys Arg Ser Leu Phe Val Arg Leu Val Pro Cys Arg Cys 
1               5                   10                  15      


Leu Arg Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys 
            20                  25                  30          


Ser Leu Glu Gln Val Pro Lys Glu Ile Phe Thr Phe Glu Lys Thr Leu 
        35                  40                  45              


Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln 
    50                  55                  60                  


Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp 
65                  70                  75                  80  


Leu Thr Thr Leu Pro Ala Ser Ile Ala Asn Leu Ile Asn Leu Arg Glu 
                85                  90                  95      


Leu Asp Val Ser Lys Asn Gly Ile Gln Glu Phe Pro Glu Asn Ile Lys 
            100                 105                 110         


Asn Cys Lys Val Leu Thr Ile Val Glu Ala Ser Val Asn Pro Ile Ser 
        115                 120                 125             


Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr 
    130                 135                 140                 


Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu 
145                 150                 155                 160 


Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu 
                165                 170                 175     


Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly 
            180                 185                 190         


Ser Asn Glu Phe Thr Glu Val Pro Glu Val Leu Glu Gln Leu Ser Gly 
        195                 200                 205             


Leu Lys Glu Phe Trp Met Asp Ala Asn Arg Leu Thr Phe Ile Pro Gly 
    210                 215                 220                 


Phe Ile Gly Ser Leu Lys Gln Leu Thr Tyr Leu Asp Val Ser Lys Asn 
225                 230                 235                 240 


Asn Ile Glu Met Val Glu Glu Gly Ile Ser Thr Cys Glu Asn Leu Gln 
                245                 250                 255     


Asp Leu Leu Leu Ser Ser Asn Ser Leu Gln Gln Leu Pro Glu Pro Ile 
            260                 265                 270         


Gly Ser Leu Lys Asn Ile Thr Thr Leu Lys Ile Asp Glu Asn Gln Leu 
        275                 280                 285             


Met Tyr Leu Pro Asp Ser Ile Gly Gly Leu Ile Ser Val Glu Glu Leu 
    290                 295                 300                 


Asp Cys Ser Phe Asn Glu Val Glu Ala Leu Pro Ser Ser Ile Gly Gln 
305                 310                 315                 320 


Leu Thr Asn Leu Arg Thr Phe Ala Ala Asp His Asn Tyr Leu Gln Gln 
                325                 330                 335     


Leu Pro Pro Glu Ile Gly Ser Trp Lys Asn Ile Thr Val Leu Phe Leu 
            340                 345                 350         


His Ser Asn Lys Leu Glu Thr Leu Pro Glu Glu Met Gly Asp Met Gln 
        355                 360                 365             


Lys Leu Lys Val Ile Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro 
    370                 375                 380                 


Phe Ser Phe Thr Lys Leu Gln Gln Leu Thr Ala Met Trp Leu Ser Asp 
385                 390                 395                 400 


Asn Gln Ser Lys Pro Leu Ile Pro Leu Gln Lys Glu Thr Asp Ser Glu 
                405                 410                 415     


Thr Gln Lys Met Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg 
            420                 425                 430         


Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro Ser 
        435                 440                 445             


Leu Trp Glu Glu Gln Arg Lys Gln Arg Ala Gln Val Ala Phe Glu Cys 
    450                 455                 460                 


Asp Glu Asp Lys Asp Glu Arg Glu Ala Pro Pro Arg Glu Gly Asn Leu 
465                 470                 475                 480 


Lys Arg Tyr Pro Thr Pro Tyr Pro Asp Glu Leu Lys Asn Met Val Lys 
                485                 490                 495     


Thr Val Gln Thr Ile Val His Arg Leu Lys Asp Glu Glu Thr Asn Glu 
            500                 505                 510         


Asp Ser Gly Arg Asp Leu Lys Pro His Glu Asp Gln Gln Asp Ile Asn 
        515                 520                 525             


Lys Asp Val Gly Val Lys Thr Ser Glu Ser Thr Thr Thr Val Lys Ser 
    530                 535                 540                 


Lys Val Gly Glu Arg Glu Lys Tyr Met Ile Gly Asn Ser Val Gln Lys 
545                 550                 555                 560 


Ile Ser Glu Pro Glu Ala Glu Ile Ser Pro Gly Ser Leu Pro Val Thr 
                565                 570                 575     


Ala Asn Met Lys Ala Ser Glu Asn Leu Lys His Ile Val Asn His Asp 
            580                 585                 590         


Asp Val Phe Glu Glu Ser Glu Glu Leu Ser Ser Asp Glu Glu Met Lys 
        595                 600                 605             


Met Ala Glu Met Arg Pro Pro Leu Ile Glu Thr Ser Ile Asn Gln Pro 
    610                 615                 620                 


Lys Val Val Ala Leu Ser Asn Asn Lys Lys Asp Asp Thr Lys Glu Thr 
625                 630                 635                 640 


Asp Ser Leu Ser Asp Glu Val Thr His Asn Ser Asn Gln Asn Asn Ser 
                645                 650                 655     


Asn Cys Ser Ser Pro Ser Arg Met Ser Asp Ser Val Ser Leu Asn Thr 
            660                 665                 670         


Asp Ser Ser Gln Asp Thr Ser Leu Cys Ser Pro Val Lys Gln Thr His 
        675                 680                 685             


Ile Asp Ile Asn Ser Lys Ile Arg Gln Glu Asp Glu Asn Phe Asn Ser 
    690                 695                 700                 


Leu Leu Gln Asn Gly Asp Ile Leu Asn Ser Ser Thr Glu Glu Lys Phe 
705                 710                 715                 720 


Lys Ala His Asp Lys Lys Asp Phe Asn Leu Pro Glu Tyr Asp Leu Asn 
                725                 730                 735     


Val Glu Glu Arg Leu Val Leu Ile Glu Lys Ser Val Asp Ser Thr Ala 
            740                 745                 750         


Thr Ala Asp Asp Thr His Lys Leu Asp His Ile Asn Met Asn Leu Asn 
        755                 760                 765             


Lys Leu Ile Thr Asn Asp Thr Phe Gln Pro Glu Ile Met Glu Arg Ser 
    770                 775                 780                 


Lys Thr Gln Asp Ile Val Leu Gly Thr Ser Phe Leu Ser Ile Asn Ser 
785                 790                 795                 800 


Lys Glu Glu Thr Glu His Leu Glu Asn Gly Asn Lys Tyr Pro Asn Leu 
                805                 810                 815     


Glu Ser Val Asn Lys Val Asn Gly His Ser Glu Glu Thr Ser Gln Ser 
            820                 825                 830         


Pro Asn Arg Thr Glu Pro His Asp Ser Asp Cys Ser Val Asp Leu Gly 
        835                 840                 845             


Ile Ser Lys Ser Thr Glu Asp Leu Ser Pro Gln Lys Ser Gly Pro Val 
    850                 855                 860                 


Gly Ser Val Val Lys Ser His Ser Ile Thr Asn Met Glu Ile Gly Gly 
865                 870                 875                 880 


Leu Lys Ile Tyr Asp Ile Leu Ser Asp Asn Gly Pro Gln Gln Pro Ser 
                885                 890                 895     


Thr Thr Val Lys Ile Thr Ser Ala Val Asp Gly Lys Asn Ile Val Arg 
            900                 905                 910         


Ser Lys Ser Ala Thr Leu Leu Tyr Asp Gln Pro Leu Gln Val Phe Thr 
        915                 920                 925             


Gly Ser Ser Ser Ser Ser Asp Leu Ile Ser Gly Thr Lys Ala Ile Phe 
    930                 935                 940                 


Lys Phe Asp Ser Asn His Asn Pro Glu Glu Pro Asn Ile Ile Arg Gly 
945                 950                 955                 960 


Pro Thr Ser Gly Pro Gln Ser Ala Pro Gln Ile Tyr Gly Pro Pro Gln 
                965                 970                 975     


Tyr Asn Ile Gln Tyr Ser Ser Ser Ala Ala Val Lys Asp Thr Leu Trp 
            980                 985                 990         


His Ser Lys Gln Asn Pro Gln Ile  Asp His Ala Ser Phe  Pro Pro Gln 
        995                 1000                 1005             


Leu Leu  Pro Arg Ser Glu Ser  Thr Glu Asn Gln Ser  Tyr Ala Lys 
    1010                 1015                 1020             


His Ser  Ala Asn Met Asn Phe  Ser Asn His Asn Asn  Val Arg Ala 
    1025                 1030                 1035             


Asn Thr  Ala Tyr His Leu His  Gln Arg Leu Gly Pro  Ala Arg His 
    1040                 1045                 1050             


Gly Glu  Met Trp Ala Ile Ser  Pro Asn Asp Arg Leu  Ile Pro Ala 
    1055                 1060                 1065             


Val Thr  Arg Ser Thr Ile Gln  Arg Gln Ser Ser Val  Ser Ser Thr 
    1070                 1075                 1080             


Ala Ser  Val Asn Leu Gly Asp  Pro Gly Ser Thr Arg  Arg Ala Gln 
    1085                 1090                 1095             


Ile Pro  Glu Gly Asp Tyr Leu  Ser Tyr Arg Glu Phe  His Ser Ala 
    1100                 1105                 1110             


Gly Arg  Thr Pro Pro Met Met  Pro Gly Ser Gln Arg  Pro Leu Ser 
    1115                 1120                 1125             


Ala Arg  Thr Tyr Ser Ile Asp  Gly Pro Asn Ala Ser  Arg Pro Gln 
    1130                 1135                 1140             


Ser Ala  Arg Pro Ser Ile Asn  Glu Ile Pro Glu Arg  Thr Met Ser 
    1145                 1150                 1155             


Val Ser  Asp Phe Asn Tyr Ser  Arg Thr Ser Pro Ser  Lys Arg Pro 
    1160                 1165                 1170             


Asn Ala  Arg Val Gly Ser Glu  His Ser Leu Leu Asp  Pro Pro Gly 
    1175                 1180                 1185             


Lys Ser  Lys Val Pro Arg Asp  Trp Arg Glu Gln Val  Leu Arg His 
    1190                 1195                 1200             


Ile Gly  Ala Lys Lys Leu Glu  Lys Met Pro Leu Ser  Asn Gly Gln 
    1205                 1210                 1215             


Met Gly  Gln Pro Leu Arg Pro  Pro Ala Asn Tyr Ser  Gln Ile His 
    1220                 1225                 1230             


His Pro  Pro Gln Ala Ser Val  Ala Arg His Pro Ser  Arg Glu Gln 
    1235                 1240                 1245             


Leu Ile  Asp Tyr Leu Met Leu  Lys Val Ala His Gln  Pro Pro Tyr 
    1250                 1255                 1260             


Thr Gln  Pro His Cys Ser Pro  Arg Gln Gly His Glu  Leu Ala Lys 
    1265                 1270                 1275             


Gln Glu  Ile Arg Val Arg Val  Glu Arg Asp Pro Glu  Leu Gly Phe 
    1280                 1285                 1290             


Ser Ile  Ser Gly Gly Val Gly  Gly Arg Gly Asn Pro  Phe Arg Pro 
    1295                 1300                 1305             


Asp Asp  Asp Gly Ile Phe Val  Thr Arg Val Gln Pro  Glu Gly Pro 
    1310                 1315                 1320             


Ala Ser  Lys Leu Leu Gln Pro  Gly Asp Lys Ile Ile  Gln Ala Asn 
    1325                 1330                 1335             


Gly Tyr  Ser Phe Ile Asn Ile  Glu His Gly Gln Ala  Val Ser Leu 
    1340                 1345                 1350             


Leu Lys  Thr Phe Gln Asn Thr  Val Glu Leu Ile Ile  Val Arg Glu 
    1355                 1360                 1365             


Val Ser  Ser 
    1370     


<210>  2
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  2
ttgtcaagac cgacctgtcc ggtg                                              24


<210>  3
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  3
acgggtagcc aacgctatgt cctg                                              24


<210>  4
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  4
ctagttcaag gccagtctga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  5
cagttagggt tgctggatta                                                   20


<210>  6
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  6
cactctgtaa tcagttctta gcag                                              24


<210>  7
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  7
ggtaagacag aaactggcac cag                                               23


<210>  8
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  8
cactccaacc tccgcaaact c                                                 21


<210>  9
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  9
gaaaatggca gagatgcgac ctcc                                              24


<210>  10
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  10
gacagtatcg gcctcaggaa gatcg                                             25


<210>  11
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  11
cgcgggtacc caagtgtgta                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  12
cgttgtccaa agggtctcg                                                    19


