                         SEQUENCE LISTING

<110>  CuRNA, Inc.
 
<120>  TREATMENT OF REPROGRAMMING FACTOR RELATED DISEASES BY INHIBITION 
       OF NATURAL ANTISENSE TRANSCRIPT TO A REPROGRAMMING FACTOR

<130>  SOX2

<150>  61/179,056
<151>  2009-05-18

<150>  61/286,852
<151>  2009-12-16

<150>  61/233,996
<151>  2009-08-14

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2518
<212>  DNA
<213>  Homo sapiens

<400>  1
ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga gtgtttgcaa       60

aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga agaggagaga      120

gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa taataataac      180

aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt tgatcctgat      240

tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt tcctcgcgga      300

gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg cccgcgggcc      360

ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc ccgcgcacag      420

cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc agcaaacttc      480

ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga aaaacagccc      540

ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc agcggcgcaa      600

gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc tgggcgccga      660

gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta agcggctgcg      720

agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga aaaccaagac      780

gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg gcggcaatag      840

catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc agcgcatgga      900

cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc aggaccagct      960

gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc agcccatgca     1020

ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga cctacatgaa     1080

cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca tggctcttgg     1140

ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg ttacctcttc     1200

ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca gcatgtatct     1260

ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt cccagcacta     1320

ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct cacacatgtg     1380

agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag ggaaatggga     1440

ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc tcaaaaagaa     1500

aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag agaacaccaa     1560

tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat gagagagatc     1620

ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg gtggggaggg     1680

cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac tttttaaaag     1740

ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc aataatattt     1800

agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac ttttgtacag     1860

tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg agaatttgcc     1920

aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa atttaggaca     1980

gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg tttaaaaatt     2040

gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc ttgtttaaaa     2100

agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc aaaaatggcc     2160

atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa ctttccattt     2220

tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta tggtttgtaa     2280

tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt ccgtagttgt     2340

attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc atgtatatat     2400

ttgaactaat atcatcctta taacaggtac attttcaact taagttttta ctccattatg     2460

cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa aaaaaaaa       2518


<210>  2
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  2
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc       60

gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc      120

ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt      180

ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg      240

cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg      300

accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc      360

tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt      420

atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga      480

tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg      540

ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg      600

cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg      660

ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac      720

cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc      780

tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct      840

tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc      900

ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc      960

accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc     1020

agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg     1080

gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg     1140

gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag     1200

ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt     1260

ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac     1320

ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg     1380

gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc     1440

tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca     1500

cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag     1560

gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc     1620

cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg     1680

ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag     1740

aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc     1800

tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt     1860

gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa     1920

ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac     1980

cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca     2040

gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg     2100

tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa     2160

ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa     2220

agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat     2280

attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa     2340

ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa     2400

tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt     2460

tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg     2520

cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc     2580

atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg     2640

taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt     2700

ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa     2760

tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt     2820

ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg     2880

catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  3
<211>  1411
<212>  DNA
<213>  Homo sapiens

<400>  3
ccttcgcaag ccctcatttc accaggcccc cggcttgggg cgccttcctt ccccatggcg       60

ggacacctgg cttcggattt cgccttctcg ccccctccag gtggtggagg tgatgggcca      120

ggggggccgg agccgggctg ggttgatcct cggacctggc taagcttcca aggccctcct      180

ggagggccag gaatcgggcc gggggttggg ccaggctctg aggtgtgggg gattccccca      240

tgccccccgc cgtatgagtt ctgtgggggg atggcgtact gtgggcccca ggttggagtg      300

gggctagtgc cccaaggcgg cttggagacc tctcagcctg agggcgaagc aggagtcggg      360

gtggagagca actccgatgg ggcctccccg gagccctgca ccgtcacccc tggtgccgtg      420

aagctggaga aggagaagct ggagcaaaac ccggaggagt cccaggacat caaagctctg      480

cagaaagaac tcgagcaatt tgccaagctc ctgaagcaga agaggatcac cctgggatat      540

acacaggccg atgtggggct caccctgggg gttctatttg ggaaggtatt cagccaaacg      600

accatctgcc gctttgaggc tctgcagctt agcttcaaga acatgtgtaa gctgcggccc      660

ttgctgcaga agtgggtgga ggaagctgac aacaatgaaa atcttcagga gatatgcaaa      720

gcagaaaccc tcgtgcaggc ccgaaagaga aagcgaacca gtatcgagaa ccgagtgaga      780

ggcaacctgg agaatttgtt cctgcagtgc ccgaaaccca cactgcagca gatcagccac      840

atcgcccagc agcttgggct cgagaaggat gtggtccgag tgtggttctg taaccggcgc      900

cagaagggca agcgatcaag cagcgactat gcacaacgag aggattttga ggctgctggg      960

tctcctttct cagggggacc agtgtccttt cctctggccc cagggcccca ttttggtacc     1020

ccaggctatg ggagccctca cttcactgca ctgtactcct cggtcccttt ccctgagggg     1080

gaagcctttc cccctgtctc cgtcaccact ctgggctctc ccatgcattc aaactgaggt     1140

gcctgccctt ctaggaatgg gggacagggg gaggggagga gctagggaaa gaaaacctgg     1200

agtttgtgcc agggtttttg ggattaagtt cttcattcac taaggaagga attgggaaca     1260

caaagggtgg gggcagggga gtttggggca actggttgga gggaaggtga agttcaatga     1320

tgctcttgat tttaatccca catcatgtat cacttttttc ttaaataaag aagcctggga     1380

cacagtagat agacacactt aaaaaaaaaa a                                    1411


<210>  4
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (956)..(956)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (968)..(968)
<223>  n is a, c, g, t or u

<400>  4
ccaggactta tcagctggga taggcctcac ttacaagaca gctctgttca gtatttggaa       60

gaaagcctga caggtttctt cggaaaagtg gccatccatg gaatgaatga aatgttctct      120

ttctattcca gggattgcag tggcaaagct aggctaggtc ttggaggctg gtgtaaggcg      180

atgtgggtga aggcaggagg ctgatggaaa gactgggggg aagaaaagcc gaaatggatt      240

cacggtgcct tggatgaagg acgagagggg aactgcaagc tccttcaact ggttctgtcc      300

ggtgagaagt gatcaagctt gggctgacaa gaggctcagg gagccctcac gttctttcgc      360

ttttttacct gccaatcaaa ctgctacaag acaacaccct gatctggcat ggacatgtcc      420

gtgtttacct taatattaca cctggattaa acagaaaaca gtgctgtatt ttgaagagcg      480

ccgaatatgt atgcattttg agaaacccaa tctcaccctt tccgggttcc caagaactaa      540

aacaagccat aacttgagag aaaaaggaga accttcgggg ggcaggaagg ttgattggaa      600

ataacttaag gaaagtctgc agaattcttt tttttacaac ttttctgagt ttccagtggg      660

tatatttagt gtgagtttga cagtaacagg ctagggaggg cagagattgg agaaattggg      720

ggtcggggga gtgattatgg gaagaaggtt agtaaggaac aaaacaatgc accgttttgt      780

aaagataata aatggaacgt ggctggtaga tactattcag tacattttct tagggtgagt      840

aagggtagac caggggagga gggggcggag agagtgttac agaagaaaga aaataagtaa      900

ccctgatggt ttaagccctt tataaaaaga aatggcatca ggtttttttt ctttantccc      960

ccacccancc tttgtagtca agtgcattta aag                                   993


<210>  5
<211>  493
<212>  DNA
<213>  Homo sapiens

<400>  5
aaaaagaagg ctgtaagctc agacaacaag tagcaaaaga aacactgacc actcacaggc       60

tggggattca gaacctgcgg atgtggaggg ccagagggct gaatttgcaa gttgggcaat      120

ggggaaagcc ttcacaaagg agaaagcctt tgggctggaa ttggaggagt aggagtcaat      180

agagagagaa gagagtaaag ggcaaggcca tcattccagg tttagggagc aagtacaaag      240

acacagagaa atggaaggct tggcctgttt ggagaatgtc aagctgtctg gggttgagag      300

aaagacattc taacaaggct tccattaaag aggctagatt tgctgcttgg acattttcta      360

gctcttctga gacaactttt tgttgagtta agcgaaaatg aatgaaaatc agatggacca      420

tatttctctt gaatgcacac gggcttaaaa acgaagggga aaaagaactt gaccagaatg      480

tgtcttggct ttt                                                         493


<210>  6
<211>  418
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, t or u

<400>  6
ttaagacagg gtctcacttt gttgcccaga ctggagtgca gtggagtaca atgatggctc       60

aatgtagcct cgatctactg ggccaaagca atccttctgc tccagcctcc taagtggctg      120

ggaccacagg cttggaccac tgtgccctgt tagttttttt atttttagta gagatggggc      180

cctgccatgt tacccaggct ggtcttgaac tcctgtcctc aagaaatcct cccgcctctg      240

ccgcccagtg tcatgattaa aggcgtgagc caccacaccc aactttcaac tcccaacccg      300

ctccctggca ctctctcagg ctctgcacat cccagctgtc tggaatcact ccacacctnc      360

atgttcttca ggaacccagg tgcttgaccc cctctcccag accttggcac tgtgcctt        418


<210>  7
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  7
auaauaaaug gaacguggcu gguagau                                           27


<210>  8
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  8
cugaguuucc aguggguaua uuuagug                                           27


<210>  9
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  9
tgagtggtca gtgtttctt                                                    19


<210>  10
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  10
gtgtctttgt acttgctccc t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  11
ccctttactc tcttctctct c                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  12
ttgctacttg ttgtctgag                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  13
gccatcattg tactccact                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  14
agttgggtgt ggtggctca                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  15
tggtcccagc cacttaggag                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  16
ggcgggagga tttcttgagg a                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, t or u

<400>  17
atgnaggtgt ggagtgattc                                                   20


