
                                SEQUENCE LISTING

<110> GLAXO GROUP LIMITED
      CLARKE, Neil James
      FORD, Susannah Karen
      HAMBLIN, Paul Andrew
      MARTIN, Stephen

<120> Antigen-binding proteins
  

<130> PB63683

<150> US61/181881         
<151> 2009-05-28  

<160> 65

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1350
<212> DNA
<213> Homo Sapiens

<220> 
<223> Homo

<400> 1
caggtgcagc tgcaggagag cggccccggc ctggtgaaac cctccgagac cctgagcctg 60
acctgcaccg tgagcggcgg cagcatcagc atctactact ggagctggat caggcagccc 120
ccaggaaagg gcctcgagtg gatcggctac gtgtactaca gcggcagcac caactacaac 180
cccagcctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg 240
aagctgaact ctgtcaccgc cgccgatacc gccgtgtatt actgcgccag gggcggctac 300
gacttttgga gcggctactt cgactactgg ggccagggaa cactagtgac cgtgtccagc 360
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc 420
ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gaccgtgtcc 480
tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc 540
ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc 600
tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc 660
aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc 720
cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc 780
gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg 840
tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac 900
agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag 960
gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc 1020
aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag 1080
ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc 1140
gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg 1200
ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg 1260
cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc 1320
cagaagagcc tgagcctgtc ccctggcaag                                  1350

<210> 2
<211> 450
<212> PRT
<213> Homo Sapiens

<220> 
<223> Humanised sequence

<400> 2
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ile Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Gly Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 3
<211> 645
<212> DNA
<213> Aritifical Sequence

<220> 
<223> Humanised antibody sequence

<400> 3
gagatcgtga tgacccagag ccccgccacc ctgagcgtgt cccccggcga gagggccacc 60
ctgagctgca gggcctctca gagcgtggac agcaacctgg cctggtacag gcagaagccc 120
ggacaggccc caaggctgct gatctacggc gccagcacca gagcaaccgg cattcccgcc 180
aggtttagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagagc 240
gaggacttcg ccgtctacta ctgccagcag tacatcaact ggccccccat caccttcggc 300
cagggcacca ggctggagat caagcgtacg gtggccgccc ccagcgtgtt catcttcccc 360
cccagcgatg agcagctgaa gagcggcacc gccagcgtgg tgtgtctgct gaacaacttc 420
tacccccggg aggccaaggt gcagtggaag gtggacaatg ccctgcagag cggcaacagc 480
caggagagcg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg 540
accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag 600
ggcctgtcca gccccgtgac caagagcttc aaccggggcg agtgc                 645

<210> 4
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 4
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Asn
            20                  25                  30          
Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ile Asn Trp Pro Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 5
<211> 1344
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 5
caggtgcagc tggtgcagcc cggcgcagaa gtcaagaagc ccggcactag cgtgaagctg 60
agctgcaagg ccagcggcta caccttcacc acctactgga tgcactgggt gaggcaggcc 120
cccggacagg gactggagtg gattggcgag atcaacccca ccaacggcca caccaactac 180
aaccagaagt tccagggcag ggccacactg accgtggaca agagcacctc caccgcctac 240
atggaactga gcagcctgag gagcgaggac accgccgtgt attactgcgc caggaactac 300
gtgggcagca tcttcgacta ctggggccag ggcacactag tgaccgtgtc cagcgccagc 360
accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca 420
gccgccctgg gctgcctggt gaaggactac ttccccgaac cggtgaccgt gtcctggaac 480
agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg 540
tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc 600
tgtaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc 660
tgtgacaaga cccacacctg ccccccctgc cctgcccccg agctgctggg aggccccagc 720
gtgttcctgt tcccccccaa gcctaaggac accctgatga tcagcagaac ccccgaggtg 780
acctgtgtgg tggtggatgt gagccacgag gaccctgagg tgaagttcaa ctggtacgtg 840
gacggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caacagcacc 900
taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaggagtac 960
aagtgtaagg tgtccaacaa ggccctgcct gcccctatcg agaaaaccat cagcaaggcc 1020
aagggccagc ccagagagcc ccaggtgtac accctgcccc ctagcagaga tgagctgacc 1080
aagaaccagg tgtccctgac ctgcctggtg aagggcttct accccagcga catcgccgtg 1140
gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac 1200
agcgatggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag 1260
ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag 1320
agcctgagcc tgtcccctgg caag                                        1344

<210> 6
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 6
Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Pro Thr Asn Gly His Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Tyr Val Gly Ser Ile Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             


<210> 7
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 7
gacatcgtga tgactcagag ccccgacagc ctggctatgt cactgggcga gagggtgacc 60
ctgaactgca aggccagcga gaacgtggtg agctacgtga gctggtatca gcagaagccc 120
ggccagagcc ccaaactcct gatctacggc gcctccaaca gggagtctgg cgtccccgac 180
aggttcagcg gcagcggaag cgccaccgac ttcaccctga ccatcagcag cgtgcaggcc 240
gaagacgtgg ccgattacca ctgcggccag agctacaact acccctacac cttcggccag 300
ggcaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 8
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Met Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Val Ser Tyr
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Asp Tyr His Cys Gly Gln Ser Tyr Asn Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 9
<211> 1350
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 9
gaggtgcagc tcgtccagag cggcgcagaa gtgaagaagc ccggcgccag cgtgaaggtg 60
agctgcaagg tgagcggcta caccttctcc ggcaactgga tcgagtgggt gaggcaggcc 120
cccgggaaag gcctggagtg gatcggcgag atcctgcccg gcagcggcaa caccaactac 180
aacgagaagt tcaagggcaa ggccaccatg accgccgaca ccagcaccga caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgctgtgt actattgcgc caggggcggc 300
cactactacg gcagctcttg ggactactgg ggacagggca cactagtgac cgtgtccagc 360
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc 420
ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gaccgtgtcc 480
tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc 540
ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc 600
tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc 660
aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc 720
cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc 780
gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg 840
tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac 900
agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag 960
gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc 1020
aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag 1080
ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc 1140
gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg 1200
ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg 1260
cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc 1320
cagaagagcc tgagcctgtc ccctggcaag                                  1350

<210> 10
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 10
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Ser Gly Asn
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly His Tyr Tyr Gly Ser Ser Trp Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 11
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 11
gacatcgtga tgacccagtc tcccagcagc ctgagcgcca gcgtgggcga tagggtcacc 60
atcacctgca aggccagcga gaacgtggtg acctacgtga gctggtacca gcagaagccc 120
gggaaggccc ccaaactgct gatctacggc gcctccaacc gatacaccgg cgtgcccgac 180
aggttcagcg gaagcggcag cggcacagac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgcggccag ggctacagct acccctatac cttcggccag 300
ggcaccaagc tcgagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 12
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised sequence

<400> 12
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 13
<211> 1722
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 13
caggtgcagc tgcaggagag cggccccggc ctggtgaaac cctccgagac cctgagcctg 60
acctgcaccg tgagcggcgg cagcatcagc atctactact ggagctggat caggcagccc 120
ccaggaaagg gcctcgagtg gatcggctac gtgtactaca gcggcagcac caactacaac 180
cccagcctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg 240
aagctgaact ctgtcaccgc cgccgatacc gccgtgtatt actgcgccag gggcggctac 300
gacttttgga gcggctactt cgactactgg ggccagggaa cactagtgac cgtgtccagc 360
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc 420
ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gaccgtgtcc 480
tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc 540
ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc 600
tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc 660
aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc 720
cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc 780
gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg 840
tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac 900
agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag 960
gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc 1020
aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag 1080
ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc 1140
gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg 1200
ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg 1260
cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc 1320
cagaagagcc tgagcctgtc ccctggcaag accgtggccg ccccctcggg atccgaggtg 1380
cagctcctgg tcagcggcgg cggcctggtc cagcccggag gctcactgag gctgagctgc 1440
gccgctagcg gcttcacctt caaggcctac cccatgatgt gggtcaggca ggcccccggc 1500
aaaggcctgg agtgggtgtc tgagatcagc cccagcggca gctacaccta ctacgccgac 1560
agcgtgaagg gcaggttcac catcagcagg gacaacagca agaacaccct gtacctgcag 1620
atgaactctc tgagggccga ggacaccgcc gtgtactact gcgccaagga ccccaggaag 1680
ctggactatt ggggccaggg cactctggtg accgtgagca gc                    1722

<210> 14
<211> 574
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ile Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Gly Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys Thr Val Ala Ala Pro Ser Gly Ser Glu Val Gln Leu Leu Val
    450                 455                 460                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
465                 470                 475                 480 
Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr Pro Met Met Trp Val Arg
                485                 490                 495     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Glu Ile Ser Pro Ser
            500                 505                 510         
Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        515                 520                 525             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
    530                 535                 540                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Pro Arg Lys
545                 550                 555                 560 
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                565                 570                 


<210> 15
<211> 1017
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 15
gagatcgtga tgacccagag ccccgccacc ctgagcgtgt cccccggcga gagggccacc 60
ctgagctgca gggcctctca gagcgtggac agcaacctgg cctggtacag gcagaagccc 120
ggacaggccc caaggctgct gatctacggc gccagcacca gagcaaccgg cattcccgcc 180
aggtttagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagagc 240
gaggacttcg ccgtctacta ctgccagcag tacatcaact ggccccccat caccttcggc 300
cagggcacca ggctggagat caagcgtacg gtggccgccc ccagcgtgtt catcttcccc 360
cccagcgatg agcagctgaa gagcggcacc gccagcgtgg tgtgtctgct gaacaacttc 420
tacccccggg aggccaaggt gcagtggaag gtggacaatg ccctgcagag cggcaacagc 480
caggagagcg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg 540
accctgagca aggccgacta cgagaagcac aaggtgtacg cctgtgaggt gacccaccag 600
ggcctgtcca gccccgtgac caagagcttc aaccggggcg agtgcaccgt ggccgccccc 660
tcgggatccg aggtgcagct cctggtcagc ggcggcggcc tggtccagcc cggaggctca 720
ctgaggctga gctgcgccgc tagcggcttc accttcaagg cctaccccat gatgtgggtc 780
aggcaggccc ccggcaaagg cctggagtgg gtgtctgaga tcagccccag cggcagctac 840
acctactacg ccgacagcgt gaagggcagg ttcaccatca gcagggacaa cagcaagaac 900
accctgtacc tgcagatgaa ctctctgagg gccgaggaca ccgccgtgta ctactgcgcc 960
aaggacccca ggaagctgga ctattggggc cagggcactc tggtgaccgt gagcagc    1017

<210> 16
<211> 339
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 16
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Asn
            20                  25                  30          
Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ile Asn Trp Pro Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Thr Val Ala Ala Pro Ser Gly Ser Glu
    210                 215                 220                 
Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
225                 230                 235                 240 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr Pro
                245                 250                 255     
Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
            260                 265                 270         
Glu Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys
        275                 280                 285             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
    290                 295                 300                 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
305                 310                 315                 320 
Lys Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                325                 330                 335     
Val Ser Ser
            


<210> 17
<211> 1716
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 17
caggtgcagc tggtgcagcc cggcgcagaa gtcaagaagc ccggcactag cgtgaagctg 60
agctgcaagg ccagcggcta caccttcacc acctactgga tgcactgggt gaggcaggcc 120
cccggacagg gactggagtg gattggcgag atcaacccca ccaacggcca caccaactac 180
aaccagaagt tccagggcag ggccacactg accgtggaca agagcacctc caccgcctac 240
atggaactga gcagcctgag gagcgaggac accgccgtgt attactgcgc caggaactac 300
gtgggcagca tcttcgacta ctggggccag ggcacactag tgaccgtgtc cagcgccagc 360
accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca 420
gccgccctgg gctgcctggt gaaggactac ttccccgaac cggtgaccgt gtcctggaac 480
agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg 540
tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc 600
tgtaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc 660
tgtgacaaga cccacacctg ccccccctgc cctgcccccg agctgctggg aggccccagc 720
gtgttcctgt tcccccccaa gcctaaggac accctgatga tcagcagaac ccccgaggtg 780
acctgtgtgg tggtggatgt gagccacgag gaccctgagg tgaagttcaa ctggtacgtg 840
gacggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caacagcacc 900
taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaggagtac 960
aagtgtaagg tgtccaacaa ggccctgcct gcccctatcg agaaaaccat cagcaaggcc 1020
aagggccagc ccagagagcc ccaggtgtac accctgcccc ctagcagaga tgagctgacc 1080
aagaaccagg tgtccctgac ctgcctggtg aagggcttct accccagcga catcgccgtg 1140
gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac 1200
agcgatggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag 1260
ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag 1320
agcctgagcc tgtcccctgg caagaccgtg gccgccccct cgggatccga ggtgcagctc 1380
ctggtcagcg gcggcggcct ggtccagccc ggaggctcac tgaggctgag ctgcgccgct 1440
agcggcttca ccttcaaggc ctaccccatg atgtgggtca ggcaggcccc cggcaaaggc 1500
ctggagtggg tgtctgagat cagccccagc ggcagctaca cctactacgc cgacagcgtg 1560
aagggcaggt tcaccatcag cagggacaac agcaagaaca ccctgtacct gcagatgaac 1620
tctctgaggg ccgaggacac cgccgtgtac tactgcgcca aggaccccag gaagctggac 1680
tattggggcc agggcactct ggtgaccgtg agcagc                           1716

<210> 18
<211> 572
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 18
Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Pro Thr Asn Gly His Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Tyr Val Gly Ser Ile Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Thr Val Ala Ala Pro Ser Gly Ser Glu Val Gln Leu Leu Val Ser Gly
    450                 455                 460                 
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
465                 470                 475                 480 
Ser Gly Phe Thr Phe Lys Ala Tyr Pro Met Met Trp Val Arg Gln Ala
                485                 490                 495     
Pro Gly Lys Gly Leu Glu Trp Val Ser Glu Ile Ser Pro Ser Gly Ser
            500                 505                 510         
Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
        515                 520                 525             
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
    530                 535                 540                 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Pro Arg Lys Leu Asp
545                 550                 555                 560 
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                565                 570         


<210> 19
<211> 1014
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 19
gacatcgtga tgactcagag ccccgacagc ctggctatgt cactgggcga gagggtgacc 60
ctgaactgca aggccagcga gaacgtggtg agctacgtga gctggtatca gcagaagccc 120
ggccagagcc ccaaactcct gatctacggc gcctccaaca gggagtctgg cgtccccgac 180
aggttcagcg gcagcggaag cgccaccgac ttcaccctga ccatcagcag cgtgcaggcc 240
gaagacgtgg ccgattacca ctgcggccag agctacaact acccctacac cttcggccag 300
ggcaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcaccgtggc cgccccctcg 660
ggatccgagg tgcagctcct ggtcagcggc ggcggcctgg tccagcccgg aggctcactg 720
aggctgagct gcgccgctag cggcttcacc ttcaaggcct accccatgat gtgggtcagg 780
caggcccccg gcaaaggcct ggagtgggtg tctgagatca gccccagcgg cagctacacc 840
tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacag caagaacacc 900
ctgtacctgc agatgaactc tctgagggcc gaggacaccg ccgtgtacta ctgcgccaag 960
gaccccagga agctggacta ttggggccag ggcactctgg tgaccgtgag cagc       1014

<210> 20
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 20
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Met Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Val Ser Tyr
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Asp Tyr His Cys Gly Gln Ser Tyr Asn Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Thr Val Ala Ala Pro Ser Gly Ser Glu Val
    210                 215                 220                 
Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
225                 230                 235                 240 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr Pro Met
                245                 250                 255     
Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Glu
            260                 265                 270         
Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        275                 280                 285             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    290                 295                 300                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
305                 310                 315                 320 
Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                325                 330                 335     
Ser Ser
        


<210> 21
<211> 1722
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 21
gaggtgcagc tcgtccagag cggcgcagaa gtgaagaagc ccggcgccag cgtgaaggtg 60
agctgcaagg tgagcggcta caccttctcc ggcaactgga tcgagtgggt gaggcaggcc 120
cccgggaaag gcctggagtg gatcggcgag atcctgcccg gcagcggcaa caccaactac 180
aacgagaagt tcaagggcaa ggccaccatg accgccgaca ccagcaccga caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgctgtgt actattgcgc caggggcggc 300
cactactacg gcagctcttg ggactactgg ggacagggca cactagtgac cgtgtccagc 360
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc 420
ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gaccgtgtcc 480
tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc 540
ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc 600
tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc 660
aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc 720
cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc 780
gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg 840
tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac 900
agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag 960
gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc 1020
aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag 1080
ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc 1140
gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg 1200
ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg 1260
cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc 1320
cagaagagcc tgagcctgtc ccctggcaag accgtggccg ccccctcggg atccgaggtg 1380
cagctcctgg tcagcggcgg cggcctggtc cagcccggag gctcactgag gctgagctgc 1440
gccgctagcg gcttcacctt caaggcctac cccatgatgt gggtcaggca ggcccccggc 1500
aaaggcctgg agtgggtgtc tgagatcagc cccagcggca gctacaccta ctacgccgac 1560
agcgtgaagg gcaggttcac catcagcagg gacaacagca agaacaccct gtacctgcag 1620
atgaactctc tgagggccga ggacaccgcc gtgtactact gcgccaagga ccccaggaag 1680
ctggactatt ggggccaggg cactctggtg accgtgagca gc                    1722

<210> 22
<211> 574
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain mAbdAb
      

<400> 22
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Ser Gly Asn
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly His Tyr Tyr Gly Ser Ser Trp Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys Thr Val Ala Ala Pro Ser Gly Ser Glu Val Gln Leu Leu Val
    450                 455                 460                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
465                 470                 475                 480 
Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr Pro Met Met Trp Val Arg
                485                 490                 495     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Glu Ile Ser Pro Ser
            500                 505                 510         
Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        515                 520                 525             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
    530                 535                 540                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Pro Arg Lys
545                 550                 555                 560 
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                565                 570                 


<210> 23
<211> 1014
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 23
gacatcgtga tgacccagtc tcccagcagc ctgagcgcca gcgtgggcga tagggtcacc 60
atcacctgca aggccagcga gaacgtggtg acctacgtga gctggtacca gcagaagccc 120
gggaaggccc ccaaactgct gatctacggc gcctccaacc gatacaccgg cgtgcccgac 180
aggttcagcg gaagcggcag cggcacagac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgcggccag ggctacagct acccctatac cttcggccag 300
ggcaccaagc tcgagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcaccgtggc cgccccctcg 660
ggatccgagg tgcagctcct ggtcagcggc ggcggcctgg tccagcccgg aggctcactg 720
aggctgagct gcgccgctag cggcttcacc ttcaaggcct accccatgat gtgggtcagg 780
caggcccccg gcaaaggcct ggagtgggtg tctgagatca gccccagcgg cagctacacc 840
tactacgccg acagcgtgaa gggcaggttc accatcagca gggacaacag caagaacacc 900
ctgtacctgc agatgaactc tctgagggcc gaggacaccg ccgtgtacta ctgcgccaag 960
gaccccagga agctggacta ttggggccag ggcactctgg tgaccgtgag cagc       1014

<210> 24
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain mAbdAb
      

<400> 24
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Thr Val Ala Ala Pro Ser Gly Ser Glu Val
    210                 215                 220                 
Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
225                 230                 235                 240 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr Pro Met
                245                 250                 255     
Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Glu
            260                 265                 270         
Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly
        275                 280                 285             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
    290                 295                 300                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
305                 310                 315                 320 
Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                325                 330                 335     
Ser Ser
        


<210> 25
<211> 116
<212> PRT
<213> Homo Sapiens

<400> 25
Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr
            20                  25                  30          
Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Ser Pro Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Pro Arg Lys Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 26
<211> 152
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anticalin
      

<400> 26
Asp Gly Gly Gly Ile Arg Arg Ser Met Ser Gly Thr Trp Tyr Leu Lys
 1               5                  10                  15      
Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn Leu Glu Ser Val
            20                  25                  30          
Thr Pro Met Thr Leu Thr Leu Leu Lys Gly His Asn Leu Glu Ala Lys
        35                  40                  45              
Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val Lys Ala Val Leu
    50                  55                  60                  
Gly Arg Thr Lys Glu Arg Lys Lys Tyr Thr Ala Asp Gly Gly Lys His
65                  70                  75                  80  
Val Ala Tyr Ile Ile Pro Ser Ala Val Arg Asp His Val Ile Phe Tyr
                85                  90                  95      
Ser Glu Gly Gln Leu His Gly Lys Pro Val Arg Gly Val Lys Leu Val
            100                 105                 110         
Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys
        115                 120                 125             
Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg
    130                 135                 140                 
Gln Ser Glu Thr Cys Ser Pro Gly
145                 150         


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 27
Gly Gly Gly Gly Ser
 1               5  


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 28
Thr Val Ala Ala Pro Ser
 1               5      


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 29
Ala Ser Thr Lys Gly Pro Thr
 1               5          


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 30
Ala Ser Thr Lys Gly Pro Ser
 1               5          


<210> 31
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 31
Gly Ser
 1      


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 32
Thr Val Ala Ala Pro Ser Gly Ser
 1               5              


<210> 33
<211> 19
<212> PRT
<213> Unknown

<220> 
<223> Signal Sequence

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 34
<211> 453
<212> PRT
<213> Homo Sapiens

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe
    50                  55                  60                  
Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 35
<211> 214
<212> PRT
<213> Homo Sapiens

<220> 
<223> Humanised
      

<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile
        35                  40                  45              
Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 36
<211> 86
<212> PRT
<213> Artificial Sequence

<220> 
<223> Adnectin
      
      

<400> 36
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg His
 1               5                  10                  15      
Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly
            20                  25                  30          
Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro Thr
        35                  40                  45              
Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val
    50                  55                  60                  
Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro Ile
65                  70                  75                  80  
Ser Ile Asn Tyr Arg Thr
                85      


<210> 37
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      
      

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Ser Tyr
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
        35                  40                  45              
Ala Ser Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Ser Cys
                85                  90                  95      
Ala Ala Tyr Ile Arg Pro Asp Thr Tyr Leu Ser Arg Asp Tyr Arg Lys
            100                 105                 110         
Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 125     


<210> 38
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanised
      
      

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val
        35                  40                  45              
Ser Ser Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Tyr Ile Arg Pro Asp Thr Tyr Leu Ser Arg Asp Tyr Arg Lys
            100                 105                 110         
Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 39
<211> 453
<212> PRT
<213> Homo Sapiens

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe
    50                  55                  60                  
Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 40
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10  


<210> 41
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 41
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser
        


<210> 42
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 42
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
            20                  25      


<210> 43
<211> 34
<212> PRT
<213> #Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 43
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser
        


<210> 44
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 44
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser
        35                  40          


<210> 45
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 45
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
 1               5                  10                  15      
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
            20                  25                  30          
Gly Ser Thr Val Ala Ala Pro Ser Gly Ser Thr Val Ala Ala Pro Ser
        35                  40                  45              
Gly Ser
    50  


<210> 46
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 46
Pro Ala Ser Gly Ser
 1               5  


<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 47
Pro Ala Ser Pro Ala Ser Gly Ser
 1               5              


<210> 48
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 48
Pro Ala Ser Pro Ala Ser Pro Ala Ser Gly Ser
 1               5                  10      


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 49
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 51
Pro Ala Val Pro Pro Pro Gly Ser
 1               5              


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 52
Pro Ala Val Pro Pro Pro Pro Ala Val Pro Pro Pro Gly Ser
 1               5                  10                  


<210> 53
<211> 20
<212> PRT
<213> linker

<400> 53
Pro Ala Val Pro Pro Pro Pro Ala Val Pro Pro Pro Pro Ala Val Pro
 1               5                  10                  15      
Pro Pro Gly Ser
            20  


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 54
Thr Val Ser Asp Val Pro Gly Ser
 1               5              


<210> 55
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 55
Thr Val Ser Asp Val Pro Thr Val Ser Asp Val Pro Gly Ser
 1               5                  10                  


<210> 56
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 56
Thr Val Ser Asp Val Pro Thr Val Ser Asp Val Pro Thr Val Ser Asp
 1               5                  10                  15      
Val Pro Gly Ser
            20  


<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 57
Thr Gly Leu Asp Ser Pro Gly Ser
 1               5              


<210> 58
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 58
Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp Ser Pro Gly Ser
 1               5                  10                  


<210> 59
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 59
Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp Ser Pro Thr Gly Leu Asp
 1               5                  10                  15      
Ser Pro Gly Ser
            20  


<210> 60
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 60
Pro Ala Ser
 1          


<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 61
Pro Ala Val Pro Pro Pro
 1               5      


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 62
Thr Val Ser Asp Val Pro
 1               5      


<210> 63
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 63
Thr Gly Leu Asp Ser Pro
 1               5      


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 64
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Gly Ser
 1               5                  10                  


<210> 65
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker
      
      
      

<400> 65
Thr Val Ala Ala Pro Ser Thr Val Ala Ala Pro Ser Thr Val Ala Ala
 1               5                  10                  15      
Pro Ser Gly Ser
            20  

