                         LISTA DE SECUENCIAS

<110>  CENTRO NACIONAL DE INVESTIGACIONES ONCOLGICAS
       CONSEJO SUPERIOR DE INVESTIGACIONES CIENTFICAS (CSIC)
 
<120>  MTODOS PARA EL DIAGNSTICO O PRONSTICO DEL CNCER COLORRECTAL

<130>  P5754PC00

<150>  ESP200930203
<151>  2009-05-25

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
1               5                   10                  15      


Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
            20                  25                  30          


Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
        35                  40                  45              


Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
    50                  55                  60                  


Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
65                  70                  75                  80  


Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                85                  90                  95      


Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
            100                 105                 110         


Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
        115                 120                 125             


Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
    130                 135                 140                 


Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
145                 150                 155                 160 


Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                165                 170                 175     


Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
            180                 185                 190         


Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
        195                 200                 205             


Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
    210                 215                 220                 


Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
225                 230                 235                 240 


Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                245                 250                 255     


Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
            260                 265                 270         


Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
        275                 280                 285             


Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
    290                 295                 300                 


His Ser Leu Ser Pro Gly Pro Ser Lys 
305                 310             


<210>  2
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  3
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Gly Glu Thr Ala Glu Glu Gln Gly Gly Pro Val Pro Pro Pro 
1               5                   10                  15      


Val Ala Pro Gly Gly Pro Gly Leu Gly Gly Ala Pro Gly Gly Arg Arg 
            20                  25                  30          


Glu Pro Lys Lys Tyr Ala Val Thr Asp Asp Tyr Gln Leu Ser Lys Gln 
        35                  40                  45              


Val Leu Gly Leu Gly Val Asn Gly Lys Val Leu Glu Cys Phe His Arg 
    50                  55                  60                  


Arg Thr Gly Gln Lys Cys Ala Leu Lys Leu Leu Tyr Asp Ser Pro Lys 
65                  70                  75                  80  


Ala Arg Gln Glu Val Asp His His Trp Gln Ala Ser Gly Gly Pro His 
                85                  90                  95      


Ile Val Cys Ile Leu Asp Val Tyr Glu Asn Met His His Gly Lys Arg 
            100                 105                 110         


Cys Leu Leu Ile Ile Met Glu Cys Met Glu Gly Gly Glu Leu Phe Ser 
        115                 120                 125             


Arg Ile Gln Glu Arg Gly Asp Gln Ala Phe Thr Glu Arg Glu Ala Ala 
    130                 135                 140                 


Glu Ile Met Arg Asp Ile Gly Thr Ala Ile Gln Phe Leu His Ser His 
145                 150                 155                 160 


Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu Leu Tyr Thr Ser 
                165                 170                 175     


Lys Glu Lys Asp Ala Val Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys 
            180                 185                 190         


Glu Thr Thr Gln Asn Ala Leu Gln Thr Pro Cys Tyr Thr Pro Tyr Tyr 
        195                 200                 205             


Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr Asp Lys Ser Cys Asp 
    210                 215                 220                 


Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu Leu Cys Gly Phe Pro 
225                 230                 235                 240 


Pro Phe Tyr Ser Asn Thr Gly Gln Ala Ile Ser Pro Gly Met Lys Arg 
                245                 250                 255     


Arg Ile Arg Leu Gly Gln Tyr Gly Phe Pro Asn Pro Glu Trp Ser Glu 
            260                 265                 270         


Val Ser Glu Asp Ala Lys Gln Leu Ile Arg Leu Leu Leu Lys Thr Asp 
        275                 280                 285             


Pro Thr Glu Arg Leu Thr Ile Thr Gln Phe Met Asn His Pro Trp Ile 
    290                 295                 300                 


Asn Gln Ser Met Val Val Pro Gln Thr Pro Leu His Thr Ala Arg Val 
305                 310                 315                 320 


Leu Gln Glu Asp Lys Asp His Trp Asp Glu Val Lys Glu Glu Met Thr 
                325                 330                 335     


Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Asp Gln Val Lys Ile Lys 
            340                 345                 350         


Asp Leu Lys Thr Ser Asn Asn Arg Leu Leu Asn Lys Arg Arg Lys Lys 
        355                 360                 365             


Gln Ala Gly Ser Ser Ser Ala Ser Gln Gly Cys Asn Asn Gln 
    370                 375                 380         


<210>  4
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  5
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Thr Val Gln Leu Arg Asn Pro Pro Arg Arg Gln Leu Lys Lys 
1               5                   10                  15      


Leu Asp Glu Asp Ser Leu Thr Lys Gln Pro Glu Glu Val Phe Asp Val 
            20                  25                  30          


Leu Glu Lys Leu Gly Glu Gly Ser Tyr Gly Ser Val Tyr Lys Ala Ile 
        35                  40                  45              


His Lys Glu Thr Gly Gln Ile Val Ala Ile Lys Gln Val Pro Val Glu 
    50                  55                  60                  


Ser Asp Leu Gln Glu Ile Ile Lys Glu Ile Ser Ile Met Gln Gln Cys 
65                  70                  75                  80  


Asp Ser Pro His Val Val Lys Tyr Tyr Gly Ser Tyr Phe Lys Asn Thr 
                85                  90                  95      


Asp Leu Trp Ile Val Met Glu Tyr Cys Gly Ala Gly Ser Val Ser Asp 
            100                 105                 110         


Ile Ile Arg Leu Arg Asn Lys Thr Leu Thr Glu Asp Glu Ile Ala Thr 
        115                 120                 125             


Ile Leu Gln Ser Thr Leu Lys Gly Leu Glu Tyr Leu His Phe Met Arg 
    130                 135                 140                 


Lys Ile His Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Asn Thr Glu 
145                 150                 155                 160 


Gly His Ala Lys Leu Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp 
                165                 170                 175     


Thr Met Ala Lys Arg Asn Thr Val Ile Gly Thr Pro Phe Trp Met Ala 
            180                 185                 190         


Pro Glu Val Ile Gln Glu Ile Gly Tyr Asn Cys Val Ala Asp Ile Trp 
        195                 200                 205             


Ser Leu Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Lys Pro Pro Tyr 
    210                 215                 220                 


Ala Asp Ile His Pro Met Arg Ala Ile Phe Met Ile Pro Thr Asn Pro 
225                 230                 235                 240 


Pro Pro Thr Phe Arg Lys Pro Glu Leu Trp Ser Asp Asn Phe Thr Asp 
                245                 250                 255     


Phe Val Lys Gln Cys Leu Val Lys Ser Pro Glu Gln Arg Ala Thr Ala 
            260                 265                 270         


Thr Gln Leu Leu Gln His Pro Phe Val Arg Ser Ala Lys Gly Val Ser 
        275                 280                 285             


Ile Leu Arg Asp Leu Ile Asn Glu Ala Met Asp Val Lys Leu Lys Arg 
    290                 295                 300                 


Gln Glu Ser Gln Gln Arg Glu Val Asp Gln Asp Asp Glu Glu Asn Ser 
305                 310                 315                 320 


Glu Glu Asp Glu Met Asp Ser Gly Thr Met Val Arg Ala Val Gly Asp 
                325                 330                 335     


Glu Met Gly Thr Val Arg Val Ala Ser Thr Met Thr Asp Gly Ala Asn 
            340                 345                 350         


Thr Met Ile Glu His Asp Asp Thr Leu Pro Ser Gln Leu Gly Thr Met 
        355                 360                 365             


Val Ile Asn Ala Glu Asp Glu Glu Glu Glu Gly Thr Met Lys Arg Arg 
    370                 375                 380                 


Asp Glu Thr Met Gln Pro Ala Lys Pro Ser Phe Leu Glu Tyr Phe Glu 
385                 390                 395                 400 


Gln Lys Glu Lys Glu Asn Gln Ile Asn Ser Phe Gly Lys Ser Val Pro 
                405                 410                 415     


Gly Pro Leu Lys Asn Ser Ser Asp Trp Lys Ile Pro Gln Asp Gly Asp 
            420                 425                 430         


Tyr Glu Phe Leu Lys Ser Trp Thr Val Glu Asp Leu Gln Lys Arg Leu 
        435                 440                 445             


Leu Ala Leu Asp Pro Met Met Glu Gln Glu Ile Glu Glu Ile Arg Gln 
    450                 455                 460                 


Lys Tyr Gln Ser Lys Arg Gln Pro Ile Leu Asp Ala Ile Glu Ala Lys 
465                 470                 475                 480 


Lys Arg Arg Gln Gln Asn Phe 
                485         


<210>  6
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


