                         SEQUENCE LISTING

<110>  MedImmune, LLC
 
<120>  MOLECULES WITH EXTENDED HALF-LIVES AND USES THEREOF

<130>  MED0035.PCT

<150>  US 61/182,858
<151>  2009-06-01

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  46
<212>  PRT
<213>  Streptococcus sp. G148

<400>  1

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  2
<211>  45
<212>  PRT
<213>  Peptostreptococcus magnus

<400>  2

Leu Lys Asn Ala Lys Glu Asp Ala Ile Ala Glu Leu Lys Lys Ala Gly 
1               5                   10                  15      


Ile Thr Ser Asp Phe Tyr Phe Asn Ala Ile Asn Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Glu Val Asn Ala Leu Lys Asn Glu Ile Leu Lys Ala 
        35                  40                  45  


<210>  3
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant DNA

<400>  3
gctctggctg aagctaaagt cctggctaac cgcgaactgg acaaatatgg tgtatccgac       60

tattacaaga acctgatcaa caatgccaaa actgttgaag gtgtaaaagc actgattgat      120

gaaattctgg ctgcactgcc tggcgccgag cccagagggc ccacaatcaa gccctgtcct      180

ccatgcaaat gcccagcacc taacctcttg ggtggaccat ccgtcttcat cttccctcca      240

aagatcaagg atgtactcat gatctccctg agccccatag tcacatgtgt ggtggtggat      300

gtgagcgagg atgacccaga tgtccagatc agctggtttg tgaacaacgt ggaagtacac      360

acagctcaga cacaaaccca tagagaggat tacaacagta ctctccgggt ggtcagtgcc      420

ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac      480

aaagacctcc cagcgcccat cgagagaacc atctcaaaac ccaaagggtc agtaagagct      540

ccacaggtat atgtcttgcc tccaccagaa gaagagatga ctaagaaaca ggtcactctg      600

acctgcatgg tcacagactt catgcctgaa gacatttacg tggagtggac caacaacggg      660

aaaacagagc taaactacaa gaacactgaa ccagtcctgg actctgatgg ttcttacttc      720

atgtacagca agctgagagt ggaaaagaag aactgggtgg aaagaaatag ctactcctgt      780

tcagtggtcc acgagggtct gcacaatcac cacacgacta agagcttctc ccggactccg      840

ggtaaa                                                                 846


<210>  4
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein

<400>  4

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Gly Ala 
        35                  40                  45              


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
    50                  55                  60                  


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
65                  70                  75                  80  


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
            100                 105                 110         


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
        115                 120                 125             


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
    130                 135                 140                 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
145                 150                 155                 160 


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
                165                 170                 175     


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
            180                 185                 190         


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
        195                 200                 205             


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
    210                 215                 220                 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
225                 230                 235                 240 


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
                245                 250                 255     


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
            260                 265                 270         


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        275                 280     


<210>  5
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Protein

<400>  5

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
            20                  25                  30          


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
        35                  40                  45              


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Gly Ala 
    50                  55                  60                  


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
65                  70                  75                  80  


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                85                  90                  95      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        115                 120                 125             


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    130                 135                 140                 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
145                 150                 155                 160 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                165                 170                 175     


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            180                 185                 190         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        195                 200                 205             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    210                 215                 220                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
225                 230                 235                 240 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                245                 250                 255     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            260                 265                 270         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        275                 280                 285             


Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Gly Ser Glu Gln 
    290                 295                 300                 


Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Gly Ser His His His 
305                 310                 315                 320 


His His His 
            


<210>  6
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Protein

<400>  6

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
            20                  25                  30          


Val Ala Asp Ala Tyr Ala Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
        35                  40                  45              


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Gly Ala 
    50                  55                  60                  


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
65                  70                  75                  80  


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                85                  90                  95      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        115                 120                 125             


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    130                 135                 140                 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
145                 150                 155                 160 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                165                 170                 175     


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            180                 185                 190         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        195                 200                 205             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    210                 215                 220                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
225                 230                 235                 240 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                245                 250                 255     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            260                 265                 270         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        275                 280                 285             


Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Gly Ser Glu Gln 
    290                 295                 300                 


Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Gly Ser His His His 
305                 310                 315                 320 


His His His 
            


<210>  7
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Protein

<400>  7

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
            20                  25                  30          


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
        35                  40                  45              


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Gly Ala 
    50                  55                  60                  


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
65                  70                  75                  80  


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                85                  90                  95      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        115                 120                 125             


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    130                 135                 140                 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln Ala 
145                 150                 155                 160 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                165                 170                 175     


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            180                 185                 190         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        195                 200                 205             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    210                 215                 220                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
225                 230                 235                 240 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                245                 250                 255     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            260                 265                 270         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        275                 280                 285             


Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Gly Ser Glu Gln 
    290                 295                 300                 


Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Gly Ser His His His 
305                 310                 315                 320 


His His His 
            


<210>  8
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  9
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  10
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210>  11
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

His Gln Asn Leu Ser Asp Gly Lys 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

His Gln Asn Ile Ser Asp Gly Lys 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Ile Ser Ser His Leu Gly Gln 
1               5               


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Lys Asn Ser Ser Met Ile Ser Asn Thr Pro 
1               5                   10      


