                         SEQUENCE LISTING

<110>  Miragen Therapeutics
       Yamada, Christina
       Marshall, William S.
 
<120>  Chemical Modification Motifs for miRNA Inhibitors and Mimetics

<130>  MIRG-019/00WO

<140>  PCT/US2010/037821
<141>  2010-06-08

<150>  US 61/185,033
<151>  2009-06-08

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  1
uggaauguaa agaaguaugu au                                                22


<210>  2
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  2
aacccguaga uccgaacuug ug                                                22


<210>  3
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  3
uacccuguag aaccgaauuu gug                                               23


<210>  4
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  4
ucccugagac ccuaacuugu ga                                                22


<210>  5
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  5
ucacagugaa ccggucucuu u                                                 21


<210>  6
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  6
uuuggucccc uucaaccagc ug                                                22


<210>  7
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  7
uuuggucccc uucaaccagc ua                                                22


<210>  8
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  8
ucuacagugc acgugucucc ag                                                22


<210>  9
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  9
ugagaugaag cacuguagcu c                                                 21


<210>  10
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  10
guccaguuuu cccaggaauc ccu                                               23


<210>  11
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  11
ucucccaacc cuuguaccag ug                                                22


<210>  12
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  12
uagcagcaca uaaugguuug ug                                                22


<210>  13
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  13
uagcagcaca ucaugguuua ca                                                22


<210>  14
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  14
uagcagcacg uaaauauugg cg                                                22


<210>  15
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  15
aacauucauu gcugucggug ggu                                               23


<210>  16
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  16
uagcagcaca gaaauauugg c                                                 21


<210>  17
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  17
uucaccaccu ucuccaccca gc                                                22


<210>  18
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  18
cccaguguuc agacuaccug uuc                                               23


<210>  19
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  19
cccaguguuu agacuaucug uuc                                               23


<210>  20
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  20
acaguagucu gcacauuggu ua                                                22


<210>  21
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  21
uggaauguaa ggaagugugu gg                                                22


<210>  22
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  22
auaagacgag caaaaagcuu gu                                                22


<210>  23
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  23
auaagacgaa caaaagguuu gu                                                22


<210>  24
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  24
uaaagugcuu auagugcagg uag                                               23


<210>  25
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  25
uagcuuauca gacugauguu ga                                                22


<210>  26
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  26
acagcaggca cagacaggca gu                                                22


<210>  27
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  27
aagcugccag uugaagaacu gu                                                22


<210>  28
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  28
agcuacauug ucugcugggu uuc                                               23


<210>  29
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  29
agcuacaucu ggcuacuggg u                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  30
caagucacua gugguuccgu u                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  31
aucacauugc cagggauuuc c                                                 21


<210>  32
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  32
uucaaguaau ccaggauagg cu                                                22


<210>  33
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  33
uucaaguaau ucaggauagg u                                                 21


<210>  34
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  34
aaggagcuca cagucuauug ag                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  35
uagcaccauc ugaaaucggu ua                                                22


<210>  36
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  36
uagcaccauu ugaaaucagu guu                                               23


<210>  37
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  37
uagcaccauu ugaaaucggu ua                                                22


<210>  38
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  38
uguaaacauc cucgacugga ag                                                22


<210>  39
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  39
uguaaacauc cuacacucag cu                                                22


<210>  40
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  40
uguaaacauc cuacacucuc agc                                               23


<210>  41
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  41
uguaaacauc cccgacugga ag                                                22


<210>  42
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  42
uguaaacauc cuugacugga ag                                                22


<210>  43
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  43
ucucacacag aaaucgcacc cgu                                               23


<210>  44
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  44
gaaguuguuc gugguggauu cg                                                22


<210>  45
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  45
acuggacuua gggucagaag gc                                                22


<210>  46
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  46
acuggacuug gagucagaag g                                                 21


<210>  47
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  47
cagcagcaau ucauguuuug aa                                                22


<210>  48
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  48
ucacuccucu ccucccgucu u                                                 21


<210>  49
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  49
ucaggcucag uccccucccg au                                                22


<210>  50
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  50
uccuguacug agcugccccg ag                                                22


<210>  51
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  51
cagcagcaca cugugguuug u                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  52
uuaagacuug cagugauguu u                                                 21


<210>  53
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  53
ucggggauca ucaugucacg aga                                               23


<210>  54
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  54
uauugcacuu gucccggccu gu                                                22


<210>  55
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  55
uauugcacuc gucccggccu cc                                                22


<210>  56
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  56
ugagguagua gguuguauag uu                                                22


<210>  57
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  57
ugagguagua gguugugugg uu                                                22


<210>  58
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  58
ugagguagua gguuguaugg uu                                                22


<210>  59
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  59
agagguagua gguugcauag uu                                                22


<210>  60
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  60
ugagguagga gguuguauag uu                                                22


<210>  61
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  61
ugagguagua gauuguauag uu                                                22


<210>  62
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  62
ugagguagua guuuguacag uu                                                22


<210>  63
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  63
aaaccguuac cauuacugag uu                                                22


<210>  64
<211>  98
<212>  RNA
<213>  Homo sapiens

<400>  64
uugaggccuu aaaguacugu agcagcacau caugguuuac augcuacagu caagaugcga       60

aucauuauuu gcugcucuag aaauuuaagg aaauucau                               98


<210>  65
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  65
acgggcgagc uuuuggcccg gguuauaccu gaugcucacg uauaagacga gcaaaaagcu       60

tguuggucag a                                                            71


<210>  66
<211>  72
<212>  RNA
<213>  Homo sapiens

<400>  66
ugucggguag cuuaucagac ugauguugac uguugaaucu cauggcaaca ccagucgaug       60

ggcugucuga ca                                                           72


<210>  67
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  67
accaugaugu gcugcu                                                       16


<210>  68
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  68
accaugaugu gcugcu                                                       16


<210>  69
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<220>
<223>  Anti-miR-15b polynucleotide

<400>  69
uguaaaccau gaugugcugc ua                                                22


<210>  70
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  70
uguaaaccau gaugugcugc ua                                                22


<210>  71
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-208a polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  71
cuuuuugcuc gucuua                                                       16


<210>  72
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-208a polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  72
cuuuuugcuc gucuua                                                       16


<210>  73
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-208a polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  73
acaagcuuuu ugcucgucuu au                                                22


<210>  74
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-208a polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  74
acaagcuuuu ugcucgucuu au                                                22


<210>  75
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-21 polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  75
aucagucuga uaagcu                                                       16


<210>  76
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-21 polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  76
aucagucuga uaagcu                                                       16


<210>  77
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-21 polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  77
ucaacaucag ucugauaagc ua                                                22


<210>  78
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-21 polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  78
ucaacaucag ucugauaagc ua                                                22


<210>  79
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<400>  79
accaugaugu gcugcu                                                       16


<210>  80
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  May contain a phosphorothioate moiety

<400>  80
accaugaugu gcugcu                                                       16


<210>  81
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide
<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  81
accaugaugu gcugcu                                                       16


<210>  82
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  82
accaugaugu gcugcu                                                       16


<210>  83
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a abasic residue cap

<400>  83
accaugaugu gcugcu                                                       16


<210>  84
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  84
accaugaugu gcugcu                                                       16


<210>  85
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<400>  85
accaugaugu gcugcu                                                       16


<210>  86
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  May contain a phosphorothioate moiety

<400>  86
accaugaugu gcugcu                                                       16


<210>  87
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  87
accaugaugu gcugcu                                                       16


<210>  88
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  88
accaugaugu gcugcu                                                       16


<210>  89
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a abasic residue cap

<400>  89
accaugaugu gcugcu                                                       16


<210>  90
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  90
accaugaugu gcugcu                                                       16


<210>  91
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<400>  91
accaugaugu gcugcu                                                       16


<210>  92
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  May contain a phosphorothioate moiety

<400>  92
accaugaugu gcugcu                                                       16


<210>  93
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  93
accaugaugu gcugcu                                                       16


<210>  94
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<400>  94
accaugaugu gcugcu                                                       16


<210>  95
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a abasic residue cap

<400>  95
accaugaugu gcugcu                                                       16


<210>  96
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  96
accaugaugu gcugcu                                                       16


<210>  97
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue


<400>  97
accatgatgt gctgct                                                       16


<210>  98
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  May contain a phosphorothioate moiety

<400>  98
accatgatgt gctgct                                                       16


<210>  99
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue

<400>  99
accatgatgt gctgct                                                       16


<210>  100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<400>  100
uguaaaccau gaugugcugc ua                                                22


<210>  101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  May contain a phosphorothioate moiety

<400>  101
uguaaaccau gaugugcugc ua                                                22


<210>  102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<400>  102
uguaaaccau gaugugcugc ua                                                22


<210>  103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<400>  103
uguaaaccau gaugugcugc ua                                                22


<210>  104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a abasic residue cap

<400>  104
uguaaaccau gaugugcugc ua                                                22


<210>  105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  105
uguaaaccau gaugugcugc ua                                                22


<210>  106
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<400>  106
uguaaaccau gaugugcugc ua                                                22


<210>  107
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  May contain a phosphorothioate moiety

<400>  107
uguaaaccau gaugugcugc ua                                                22


<210>  108
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<400>  108
uguaaaccau gaugugcugc ua                                                22


<210>  109
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<400>  109
uguaaaccau gaugugcugc ua                                                22


<210>  110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a abasic residue cap

<400>  110
uguaaaccau gaugugcugc ua                                                22


<210>  111
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 fluorinated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  111
uguaaaccau gaugugcugc ua                                                22


<210>  112
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<400>  112
uguaaaccau gaugugcugc ua                                                22


<210>  113
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  May contain a phosphorothioate moiety

<400>  113
uguaaaccau gaugugcugc ua                                                22


<210>  114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<400>  114
uguaaaccau gaugugcugc ua                                                22


<210>  115
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<400>  115
uguaaaccau gaugugcugc ua                                                22


<210>  116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a abasic residue cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a abasic residue cap

<400>  116
uguaaaccau gaugugcugc ua                                                22


<210>  117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May have a phosphorothioate monophosphate cap

<400>  117
uguaaaccau gaugugcugc ua                                                22


<210>  118
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a locked nucliec acid residue

<400>  118
tgtaaaccat gatgtgctgc ta                                                22


<210>  119
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a locked nucliec acid residue

<400>  119
tgtaaaccat gatgtgctgc ta                                                22


<210>  120
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  May be a locked nucliec acid residue

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May be a deoxy residue

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  May be a locked nucliec acid residue

<400>  120
tgtaaaccat gatgtgctgc ta                                                22


<210>  121
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  121
accaugaugu gcugcu                                                       16


<210>  122
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-miR-15b polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May have a phosphorothioate monophosphate cap

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  May be 2 O-methylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  May contain a phosphorothioate moiety

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  May have a phosphorothioate monophosphate cap

<400>  122
accaugaugu gcugcu                                                       16


