                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  ANTI NOTCH-1 ANTIBODIES

<130>  PC33897A

<150>  61/218,193
<151>  2009-06-18

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atgccgccgc tcctggcacc tctgctctgc ctggcactgc tacccgctct cgctgcacga       60

ggtccgcgat gctcccaacc aggtgagacc tgcctgaatg gaggtaagtg tgaagcagcc      120

aatggcacgt gcctgtgcct gggccccttc acgggccccg aatgccagtt cccggccagc      180

agcccctgcc tgggcggcaa cccctgctac aaccagggga cctgtgagcc cacatccgag      240

agccccttct accgttgcct gtgccccgcc aaattcaacg ggctcttgtg ccacatcctg      300

gactacagct tcgggggtgg ggccgggcgc gacatccccc cgccgctgat cgaggaggcg      360

tgcgagctgc ccgagtgcca ggaggacgcg ggcaacaagg tctgcagcct gcagtgcaac      420

aaccacgcgt gcggctggga cggcggtgac tgctccctca acttcaatga cccctggaag      480

aactgcacgc agtctctgca gtgctggaag tacttcagtg acggccactg tgacagccag      540

tgcaactcag ccggctgcct cttcgacggc tttgactgcc agcgtgcgga aggccagtgc      600

aaccccctgt acgaccagta ctgcaaggac cacttcagcg acgggcactg cgaccagggc      660

tgcaacagcg cggagtgcga gtgggacggg ctggactgtg cggagcatgt acccgagagg      720

ctggcggccg gcacgctggt ggtggtggtg ctgatgccgc cggagcagct gcgcaacagc      780

tccttccact tcctgcggga gctcagccgc gtgctgcaca ccaacgtggt cttcaagcgt      840

gacgcacacg gccagcagat gatcttcccc tactacggcc gcgaggagga gctgcgcaag      900

caccccatca agcgtgccgc cgagggctgg gccgcacctg acgccctgct gggccaggtg      960

aaggcctcgc tgctccctgg tggcagcgag ggtgggcggc ggcggaggga gctggacccc     1020

atggacgtcc gcggctccat cgtctacctg gagattgaca accggcagtg tgtgcaggcc     1080

tcctcgcagt gcttccagag tgccaccgac gtggccgcat tcctgggagc gctcgcctcg     1140

ctgggcagcc tcaacatccc ctacaagatc gaggccgtgc agagtgagac cgtggagccg     1200

cccccgccgg cgcagaagcg ccggcggcag catggccagc tctggttccc tgagggcttc     1260

aaagtgtctg aggccagcaa gaagaagcgg cgggagcccc tcggcgagga ctccgtgggc     1320

ctcaagcccc tgaagaacgc ttcagac                                         1347


<210>  2
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Cys Leu Cys Leu Gly 
        35                  40                  45              


Pro Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Leu 
    50                  55                  60                  


Gly Gly Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
65                  70                  75                  80  


Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
                85                  90                  95      


Cys His Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile 
            100                 105                 110         


Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
        115                 120                 125             


Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys 
    130                 135                 140                 


Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
145                 150                 155                 160 


Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
                165                 170                 175     


Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
            180                 185                 190         


Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
        195                 200                 205             


Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
    210                 215                 220                 


Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
225                 230                 235                 240 


Leu Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln 
                245                 250                 255     


Leu Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu 
            260                 265                 270         


His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 
        275                 280                 285             


Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
    290                 295                 300                 


Arg Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val 
305                 310                 315                 320 


Lys Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg 
                325                 330                 335     


Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile 
            340                 345                 350         


Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala 
        355                 360                 365             


Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu 
    370                 375                 380                 


Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro 
385                 390                 395                 400 


Pro Pro Pro Ala Gln Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe 
                405                 410                 415     


Pro Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu 
            420                 425                 430         


Pro Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser 
        435                 440                 445             


Asp 
    


<210>  3
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atgcctccgc tcctggcacc tctgctctgc ctggcactgc tacccgctct cgctgcacga       60

ggtccgcgat gctcccaacc aggtgagacc tgcctgaatg gaggtaagtg tgaagcagcc      120

aatggcacgt gcctgtgcct gggccccttc acgggccccg aatgccagtt cccggccagc      180

agcccctgcc tgggcggcaa cccctgctac aaccagggga cctgtgagcc cacatccgag      240

agccccttct accgttgcct gtgccccgcc aaattcaacg ggctcttgtg ccacatcctg      300

gactacagct tcgggggtgg ggccgggcgc gacatccccc cgccgctgat cgaggaggcg      360

tgcgagctgc ccgagtgcca ggaggacgcg ggcaacaagg tctgcagcct gcagtgcaac      420

aaccacgcgt gcggctggga cggcggtgac tgctccctca acttcaatga cccctggaag      480

aactgcacgc agtctctgca gtgctggaag tacttcagtg acggccactg tgacagccag      540

tgcaactcag ccggctgcct cttcgacggc tttgactgcc agcgtgcgga aggccagtgc      600

aaccccctgt acgaccagta ctgcaaggac cacttcagcg acgggcactg cgaccagggc      660

tgcaacagcg cggagtgcga gtgggacggg ctggactgtg cggagcatgt acccgagagg      720

ctggcggccg gcacgctggt ggtggtggtg ctgatgccgc cggagcagct gcgcaacagc      780

tccttccact tcctgcggga gctcagccgc gtgctgcaca ccaacgtggt cttcaagcgt      840

gacgcacacg gccagcagat gatcttcccc tactacggcc gcgaggagga gctgcgcaag      900

caccccatca agcgtgccgc cgagggctgg gccgcacctg acgccctgct gggccaggtg      960

aaggcctcgc tgctccctgg tggcagcgag ggtgggcggc ggcggaggga gctggacccc     1020

atggacgtcc gcggctccat cgtctacctg gagattgaca accggcagtg tgtgcaggcc     1080

tcctcgcagt gcttccagag tgccaccgac gtggccgcat tcctgggagc gctcgcctcg     1140

ctgggcagcc tcaacatccc ctacaagatc gaggccgtgc agagtgagac cgtggagccg     1200

cccccgccgg cgcagctgca cttcatgtac gtggcggcgg ccgcctttgt gcttctgttc     1260

ttcgtgggct gcggggtgct gctgtcc                                         1287


<210>  4
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Cys Leu Cys Leu Gly 
        35                  40                  45              


Pro Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Leu 
    50                  55                  60                  


Gly Gly Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
65                  70                  75                  80  


Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
                85                  90                  95      


Cys His Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile 
            100                 105                 110         


Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
        115                 120                 125             


Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys 
    130                 135                 140                 


Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
145                 150                 155                 160 


Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
                165                 170                 175     


Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
            180                 185                 190         


Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
        195                 200                 205             


Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
    210                 215                 220                 


Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
225                 230                 235                 240 


Leu Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln 
                245                 250                 255     


Leu Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu 
            260                 265                 270         


His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 
        275                 280                 285             


Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
    290                 295                 300                 


Arg Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val 
305                 310                 315                 320 


Lys Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg 
                325                 330                 335     


Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile 
            340                 345                 350         


Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala 
        355                 360                 365             


Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu 
    370                 375                 380                 


Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro 
385                 390                 395                 400 


Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe 
                405                 410                 415     


Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
            420                 425                 


<210>  5
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  5
caggttcagc tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt aactactgga tggagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaaggggtag aactaactac      180

aatgagaact tcaagggcaa ggccacattc actgcagata catcctccaa cacagtctac      240

atgcaactca acagcctgac atctgaggac tctgccgtct attactgtgc aagattccac      300

agctcggcct attactatac tatggactac tggggtcaaa gaacctcggt caccgtctcc      360

tca                                                                    363


<210>  6
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Gly Arg Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe His Ser Ser Ala Tyr Tyr Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Arg Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  7
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtatt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  8
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  9
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  9
cgctcaagta ctggggctgt tacaactagt aactatgcca ac                          42


<210>  10
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  10
ggtaccaaca accgagctcc a                                                 21


<210>  11
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  11
gctctatggt acagcaacca ctgggtg                                           27


<210>  12
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  12

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  13
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  14

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  15
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  15
aactactgga tggag                                                        15


<210>  16
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  16
gagattttac ctggaagggg tagaactaac tacaatgaga acttcaaggg c                51


<210>  17
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  17
ttccacagct cggcctatta ctatactatg gactac                                 36


<210>  18
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  18

Asn Tyr Trp Met Glu 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Ile Leu Pro Gly Arg Gly Arg Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  20

Phe His Ser Ser Ala Tyr Tyr Tyr Thr Met Asp Tyr 
1               5                   10          


<210>  21
<211>  864
<212>  DNA
<213>  Homo sapiens

<400>  21
gaggaggcgt gcgagctgcc cgagtgccag gaggacgcgg gcaacaaggt ctgcagcctg       60

cagtgcaaca accacgcgtg cggctgggac ggcggtgact gctccctcaa cttcaatgac      120

ccctggaaga actgcacgca gtctctgcag tgctggaagt acttcagtga cggccactgt      180

gacagccagt gcaactcagc cggctgcctc ttcgacggct ttgactgcca gcgtgcggaa      240

ggccagtgca accccctgta cgaccagtac tgcaaggacc acttcagcga cgggcactgc      300

gaccagggct gcaacagcgc ggagtgcgag tgggacgggc tggactgtgc ggagcatgta      360

cccgagaggc tggcggccgg cacgctggtg gtggtggtgc tgatgccgcc ggagcagctg      420

cgcaacagct ccttccactt cctgcgggag ctcagccgcg tgctgcacac caacgtggtc      480

ttcaagcgtg acgcacacgg ccagcagatg atcttcccct actacggccg cgaggaggag      540

ctgcgcaagc accccatcaa gcgtgccgcc gagggctggg ccgcacctga cgccctgctg      600

ggccaggtga aggcctcgct gctccctggt ggcagcgagg gtgggcggcg gcggagggag      660

ctggacccca tggacgtccg cggctccatc gtctacctgg agattgacaa ccggcagtgt      720

gtgcaggcct cctcgcagtg cttccagagt gccaccgacg tggccgcatt cctgggagcg      780

ctcgcctcgc tgggcagcct caacatcccc tacaagatcg aggccgtgca gagtgagacc      840

gtggagccgc ccccgccggc gcag                                             864


<210>  22
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys 
1               5                   10                  15      


Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly 
            20                  25                  30          


Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln Ser 
        35                  40                  45              


Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln Cys 
    50                  55                  60                  


Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Arg Ala Glu 
65                  70                  75                  80  


Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe Ser 
                85                  90                  95      


Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp 
            100                 105                 110         


Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr 
        115                 120                 125             


Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu Arg Asn Ser Ser 
    130                 135                 140                 


Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His Thr Asn Val Val 
145                 150                 155                 160 


Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe Pro Tyr Tyr Gly 
                165                 170                 175     


Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ala Ala Glu Gly 
            180                 185                 190         


Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val Lys Ala Ser Leu Leu 
        195                 200                 205             


Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg Glu Leu Asp Pro Met 
    210                 215                 220                 


Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys 
225                 230                 235                 240 


Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala 
                245                 250                 255     


Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys 
            260                 265                 270         


Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala Gln 
        275                 280                 285             


