                               SEQUENCE LISTING	

<110> RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 
      JIANGNAN UNIVERSITY 
 
<120> STEREOSPECIFIC CARBONYL REDUCTASES

<130> 00335.009WO1

<140>
<141>

<150> 61/219,610
<151> 2009-06-23

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 279
<212> PRT
<213> Candida parapsilosis

<400> 1
Met Gly Glu Ile Glu Ser Tyr Cys Asn Lys Glu Leu Gly Pro Leu Pro 
1               5                   10                  15      


Thr Lys Ala Pro Thr Leu Ser Lys Asn Val Leu Asp Leu Phe Ser Leu 
            20                  25                  30          


Lys Gly Lys Val Ala Ser Val Thr Gly Ser Ser Gly Gly Ile Gly Trp 
        35                  40                  45              


Ala Val Ala Glu Ala Tyr Ala Gln Ala Gly Ala Asp Val Ala Ile Trp 
    50                  55                  60                  


Tyr Asn Ser His Pro Ala Asp Glu Lys Ala Glu His Leu Gln Lys Thr 
65                  70                  75                  80  


Tyr Gly Val His Ser Lys Ala Tyr Lys Cys Asn Ile Ser Asp Pro Lys 
                85                  90                  95      


Ser Val Glu Glu Thr Ile Ser Gln Gln Glu Lys Asp Phe Gly Thr Ile 
            100                 105                 110         


Asp Val Phe Val Ala Asn Ala Gly Val Thr Trp Thr Gln Gly Pro Glu 
        115                 120                 125             


Ile Asp Val Asp Asn Tyr Asp Ser Trp Asn Lys Ile Ile Ser Val Asp 
    130                 135                 140                 


Leu Asn Gly Val Tyr Tyr Cys Ser His Asn Ile Gly Lys Ile Phe Lys 
145                 150                 155                 160 


Lys Asn Gly Lys Gly Ser Leu Ile Ile Thr Ser Ser Ile Ser Gly Lys 
                165                 170                 175     


Ile Val Asn Ile Pro Gln Leu Gln Ala Pro Tyr Asn Thr Ala Lys Ala 
            180                 185                 190         


Ala Cys Thr His Leu Ala Lys Ser Leu Ala Ile Glu Trp Ala Pro Phe 
        195                 200                 205             


Ala Arg Val Asn Thr Ile Ser Pro Gly Tyr Ile Asp Thr Asp Ile Thr 
    210                 215                 220                 


Asp Phe Ala Ser Lys Asp Met Lys Ala Lys Trp Trp Gln Leu Thr Pro 
225                 230                 235                 240 


Leu Gly Arg Glu Gly Leu Thr Gln Glu Leu Val Gly Gly Tyr Leu Tyr 
                245                 250                 255     


Leu Ala Ser Asn Ala Ser Thr Phe Thr Thr Gly Ser Asp Val Val Ile 
            260                 265                 270         


Asp Gly Gly Tyr Thr Cys Pro 
        275                 


<210> 2
<211> 279
<212> PRT
<213> Candida parapsilosis

<400> 2
Met Gly Glu Ile Glu Ser Tyr Cys Asn Lys Glu Leu Gly Pro Leu Pro 
1               5                   10                  15      


Thr Lys Ala Pro Thr Leu Ala Lys Asn Val Leu Asp Leu Phe Ser Leu 
            20                  25                  30          


Lys Gly Lys Val Ala Ser Val Thr Gly Ser Ser Gly Gly Ile Gly Trp 
        35                  40                  45              


Ala Val Ala Glu Ala Tyr Ala Gln Ala Gly Ala Asp Val Ala Ile Trp 
    50                  55                  60                  


Tyr Asn Ser His Pro Ala Asp Glu Lys Ala Glu His Leu Gln Lys Thr 
65                  70                  75                  80  


Tyr Gly Val Arg Ser Lys Ala Tyr Lys Cys Asn Ile Ser Asp Pro Lys 
                85                  90                  95      


Ser Val Glu Glu Thr Ile Ser Gln Gln Glu Lys Asp Phe Gly Thr Ile 
            100                 105                 110         


Asp Val Phe Val Ala Asn Ala Gly Ile Pro Trp Ala Asp Gly Pro Val 
        115                 120                 125             


Ile Asp Leu Glu Asn Tyr Asp Ala Trp Asn Lys Leu Ile Asn Thr Asp 
    130                 135                 140                 


Ile Asn Gly Val Phe Tyr Cys Ala His Ser Ile Gly Lys Ile Phe Lys 
145                 150                 155                 160 


Lys Asn Gly Lys Gly Ser Leu Ile Ile Thr Ala Ser Leu Ala Gly Ser 
                165                 170                 175     


Val Val Thr Ile Pro Gln Gln Gln Thr Pro Tyr Asn Thr Ala Lys Ala 
            180                 185                 190         


Ala Cys Leu His Leu Ala Lys Ser Leu Ala Val Glu Trp Ala Pro Phe 
        195                 200                 205             


Ala Arg Val Asn Thr Val Ser Pro Gly Tyr Phe Glu Thr Glu Ile Asn 
    210                 215                 220                 


Gly Phe Ala Asp Glu Asp Met Arg Glu Lys Trp Tyr Gln Leu Thr Pro 
225                 230                 235                 240 


Leu Gly Arg Met Gly Ile Thr Glu Glu Leu Val Gly Gly Tyr Leu Tyr 
                245                 250                 255     


Phe Ala Ser Asn Ala Ser Thr Phe Thr Thr Gly Ser Asp Leu Ile Ile 
            260                 265                 270         


Asp Gly Gly Phe Thr Cys Pro 
        275                 


<210> 3
<211> 279
<212> PRT
<213> Candida parapsilosis

<400> 3
Met Gly Glu Ile Glu Ser Tyr Cys Asn Lys Glu Leu Gly Pro Leu Pro 
1               5                   10                  15      


Thr Lys Ala Pro Thr Leu Ser Lys Asn Val Leu Asp Leu Phe Ser Leu 
            20                  25                  30          


Lys Gly Lys Val Ala Ser Val Thr Gly Ser Ser Gly Gly Ile Gly Trp 
        35                  40                  45              


Ala Val Ala Glu Ala Tyr Ala Gln Ala Gly Ala Asp Val Ala Ile Trp 
    50                  55                  60                  


Tyr Asn Ser His Pro Ala Asp Glu Lys Ala Glu His Leu Gln Lys Thr 
65                  70                  75                  80  


Tyr Gly Val Arg Ser Lys Ala Tyr Lys Cys Asn Ile Ser Asp Pro Lys 
                85                  90                  95      


Ser Val Glu Glu Thr Ile Ser Gln Gln Glu Lys Asp Phe Gly Thr Ile 
            100                 105                 110         


Asp Val Phe Val Ala Asn Ala Gly Val Pro Trp Thr Glu Gly Pro Glu 
        115                 120                 125             


Ile Asn Val Asp Asn Tyr Asp Ser Trp Asn Lys Ile Ile Asn Leu Asp 
    130                 135                 140                 


Leu Asn Gly Val Tyr Tyr Cys Ala His Thr Val Gly Lys Ile Phe Lys 
145                 150                 155                 160 


Lys Asn Gly Lys Gly Ser Leu Val Ile Thr Ser Ser Met Ser Gly Thr 
                165                 170                 175     


Ile Val Asn Val Pro Gln Leu Gln Ala Ala Tyr Asn Ala Ala Lys Ala 
            180                 185                 190         


Ala Cys Thr His Leu Thr Lys Ser Leu Ala Val Glu Trp Ala Pro Phe 
        195                 200                 205             


Ala Arg Val Asn Cys Val Ser Pro Gly Tyr Ile Ala Thr Glu Ile Ser 
    210                 215                 220                 


Asp Phe Val Glu Lys Asp Met Lys Ala Lys Trp Trp Gln Leu Thr Pro 
225                 230                 235                 240 


Leu Gly Arg Glu Gly Leu Ala Gln Glu Leu Val Gly Ala Tyr Leu Tyr 
                245                 250                 255     


Leu Ala Ser Asn Ala Ser Thr Tyr Thr Thr Gly Ala Asn Leu Ala Val 
            260                 265                 270         


Asp Gly Gly Tyr Thr Cys Pro 
        275                 


<210> 4
<211> 281
<212> PRT
<213> Candida parapsilosis

<400> 4
Met Ser Lys Asp Glu Thr Ile Ser Tyr Cys Asn Asp Gln Leu Gly Pro 
1               5                   10                  15      


Leu Pro Thr Thr Ala Pro Lys Val Ser Asp Asn Val Thr Asp Leu Phe 
            20                  25                  30          


Ser Phe Lys Gly Lys Val Val Ser Val Thr Gly Ser Ser Gly Gly Ile 
        35                  40                  45              


Gly Trp Ala Val Ala Glu Gly Phe Ala Gln Ala Gly Ala Asp Val Ala 
    50                  55                  60                  


Ile Trp Tyr His Ser His Asn Ala Asp Glu Lys Ala Lys Tyr Leu Gln 
65                  70                  75                  80  


Glu Lys Tyr Gly Val Lys Ser Ile Ala Tyr Gly Cys Asn Ile Gly Val 
                85                  90                  95      


Ala Glu Glu Val Gln Lys Thr Val Asp Gln Ile Glu Ser Asp Phe Gly 
            100                 105                 110         


Lys Ile Asp Val Phe Val Ala Asn Ala Gly Ile Pro Trp Thr Asp Gly 
        115                 120                 125             


Pro Glu Ile Asp Val Gln Asp Leu Ser Lys Trp Thr Lys Ile Ile Asp 
    130                 135                 140                 


Thr Asp Leu Asn Ser Val Tyr Tyr Cys Ala His Ala Ile Gly Pro Ile 
145                 150                 155                 160 


Phe Arg Lys Gln Gly Lys Gly Ser Leu Val Ile Thr Ala Ser Met Ser 
                165                 170                 175     


Ala Thr Ile Val Asn Val Pro Gln Leu Gln Ala Ala Tyr Asn Val Ala 
            180                 185                 190         


Lys Ala Gly Val Lys His Leu Ser Lys Ser Leu Ala Val Glu Trp Ala 
        195                 200                 205             


Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Ser Thr Asn 
    210                 215                 220                 


Leu Thr Thr Phe Ala Asn Pro Asp Leu Gln Lys Lys Trp Val Gln Leu 
225                 230                 235                 240 


Thr Pro Leu Gly Arg Glu Gly His Pro Lys Glu Leu Val Gly Ala Tyr 
                245                 250                 255     


Leu Tyr Leu Ala Ser Asp Ala Ala Thr Phe Thr Thr Gly Cys Asp Leu 
            260                 265                 270         


Ala Val Asp Gly Gly Tyr Thr Val Pro 
        275                 280     


<210> 5
<211> 837
<212> DNA
<213> Candida parapsilosis

<400> 5
atgggcgaaa tcgaatctta ttgtaacaaa gagttgggac cattgccaac aaaagctcca       60

actttgtcaa agaacgtgct tgacttgttt tcccttaagg gtaaagttgc ttctgtgact      120

ggatcatctg gtggtattgg ttgggctgtt gctgaagctt acgctcaagc tggtgcagat      180

gtagccattt ggtacaactc ccatccagct gatgagaaag ccgaacactt gcaaaagaca      240

tatggggtcc attcgaaagc ttacaagtgt aacattagtg acccaaagag cgttgaagaa      300

accatctctc aacaagaaaa agactttgga accatcgacg tgtttgtcgc taatgctggt      360

gttacttgga cacaaggacc agagattgat gttgacaact acgattcatg gaataagata      420

attagtgttg atttgaatgg cgtatactac tgctcacaca atatcggtaa gatcttcaaa      480

aaaaacggca aagggtcttt gatcataaca tcatcgatat ccggcaagat tgtcaatatc      540

cctcagcttc aagctccata taacacggct aaagctgctt gtacacattt ggcaaaatcc      600

ttggccatcg agtgggcacc atttgctaga gtgaacacca tttcaccagg ttatattgat      660

actgatatta cagattttgc aagcaaagat atgaaagcta agtggtggca attgacacca      720

ttgggaaggg aggggcttac tcaagagcta gttggtggat atttgtactt ggcatcgaat      780

gcgtctacat tcacaactgg ttctgatgtt gttattgacg gtggatacac gtgtcca         837


<210> 6
<211> 837
<212> DNA
<213> Candida parapsilosis

<400> 6
atgggcgaaa tcgaatctta ttgtaacaaa gagttgggac cattgccaac aaaagctcca       60

actttggcaa agaacgtgct tgacttgttt tcccttaagg gtaaagttgc ttctgtgact      120

ggatcatctg gtggtattgg ttgggctgtt gctgaggctt acgctcaagc tggtgcagat      180

gtagccattt ggtacaactc ccatccagct gatgagaaag ccgaacactt gcaaaagaca      240

tatggggtcc gttcgaaagc ttacaagtgt aacattagtg acccaaagag cgttgaagaa      300

accatctctc aacaagaaaa agactttgga accattgacg tgtttgtcgc taatgctggt      360

attccttggg ctgatggtcc ggtgattgac cttgaaaact acgatgcatg gaataaactc      420

atcaacaccg acatcaatgg tgtgttttac tgcgcacaca gtatcggtaa gatcttcaaa      480

aagaatggaa aaggatcctt aattattact gcttcactcg ctggttctgt tgtcactatt      540

ccgcaacaac aaactcctta taatactgcg aaagccgctt gtcttcattt ggcaaaatca      600

ttggcggttg agtgggcgcc atttgctaga gtcaataccg tttcaccagg ctactttgaa      660

accgagatca atggattcgc agacgaggat atgcgtgaaa agtggtatca attgacgcca      720

ttgggaagaa tgggaataac tgaagagcta gttggtgggt atttgtactt tgcttctaat      780

gcatctacat tcacaacagg ctctgatctt attatcgatg gtggattcac ctgtcca         837


<210> 7
<211> 837
<212> DNA
<213> Candida parapsilosis

<400> 7
atgggcgaaa tcgaatctta ttgcaacaaa gagttgggac cattgccaac aaaagctcca       60

actttgtcaa agaacgtgct tgacttgttt tcccttaagg gtaaagttgc ttctgtgact      120

ggatcatctg gtggtattgg ttgggctgtt gctgaggctt acgctcaagc tggtgcagac      180

gtagccattt ggtacaactc ccatccagct gatgagaaag ctgaacactt gcaaaagaca      240

tatggggtcc gttcgaaagc ttacaagtgt aacattagtg acccaaagag cgttgaagaa      300

accatctctc aacaagaaaa agactttgga accattgacg tgtttgtcgc taatgctggt      360

gtgccttgga ctgaaggacc tgaaatcaat gtcgataact acgattcatg gaacaaaatt      420

atcaacctag acttgaatgg tgtatactac tgtgctcata ccgttggtaa gattttcaag      480

aaaaacggca aaggctcctt ggtgattact tcatccatgt cgggtaccat tgttaatgtt      540

cctcaattgc aagcagccta caatgcagca aaagctgctt gcactcattt gactaaatcc      600

ttagcagttg aatgggctcc atttgctaga gtgaattgtg tttctccagg ttacattgcc      660

actgaaattt ctgattttgt tgaaaaagac atgaaagcca agtggtggca attgacacca      720

ttgggaaggg aaggtttggc ccaagaattg gttggtgctt acttgtattt ggcatctaat      780

gcttcgactt atactactgg tgctaacctc gctgtcgatg gtggttacac ttgtcca         837


<210> 8
<211> 843
<212> DNA
<213> Candida parapsilosis

<400> 8
atgagtaaag acgaaacaat ttcttactgt aatgaccaat tgggcccatt gccaaccaca       60

gctccaaaag tatctgataa cgttactgac cttttctcct tcaaaggtaa agttgtgtca      120

gtaaccgggt cctccggagg tattggttgg gctgttgctg agggcttcgc tcaagctggt      180

gcagatgtag ccatttggta tcattctcac aatgctgatg aaaaggccaa atatctccaa      240

gaaaaatacg gagtcaagtc aattgcttat ggatgtaaca ttggtgttgc tgaggaagtc      300

caaaaaacag ttgatcaaat tgaatctgat ttcggtaaga ttgacgtttt cgttgccaac      360

gctggtattc catggacgga tggaccagaa attgatgttc aagatttaag caaatggacc      420

aagattatcg acactgattt gaacagtgta tattactgtg ctcatgccat tggtcctatt      480

ttcagaaaac aaggtaaagg ctcattggtt attactgcat ccatgtcggc tacaattgtc      540

aatgttccgc aattgcaagc agcttataat gttgccaaag ctggggttaa gcacttgtca      600

aagtcgttgg cggttgaatg ggctcctttt gccagagtca acagtgtctc accaggttat      660

atttcaacaa atttgacaac ctttgccaac cctgatttgc aaaagaaatg ggtgcaattg      720

actccattgg gtagagaagg gcatccaaag gaattggttg gtgcttactt atacttggct      780

tccgatgctg ctactttcac aactggttgt gatttagctg ttgatggtgg ttatactgtc      840

cca                                                                    843


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Cofactor-binding motif peptide"


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 9
Gly Xaa Xaa Xaa Gly Xaa Gly 
1               5           


<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      catalytic tetrad peptide"

<400> 10
Asn Ser Tyr Lys 
1               


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      catalytic triad peptide"

<400> 11
Ser Tyr Lys 
1           


