
                                SEQUENCE LISTING

<110> Regeneron Pharmaceuticals, Inc.

<120> Method of Treating Cancer with DLL4 Antagonist and Chemotherapeutic Agent
  

<130> 6043A-WO

<140> To be assigned      
<141> Filed herewith  

<150> 61/301,881           
<151> 2010-02-05  

<150> 61/220,465           
<151> 2009-06-25  

<160> 118

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2058
<212> DNA
<213> Homo sapiens

<400> 1
atggcggcag cgtcccggag cgcctctggc tgggcgctac tgctgctggt ggcactttgg 60
cagcagcgcg cggccggctc cggcgtcttc cagctgcagc tgcaggagtt catcaacgag 120
cgcggcgtac tggccagtgg gcggccttgc gagcccggct gccggacttt cttccgcgtc 180
tgccttaagc acttccaggc ggtcgtctcg cccggaccct gcaccttcgg gaccgtctcc 240
acgccggtat tgggcaccaa ctccttcgct gtccgggacg acagtagcgg cggggggcgc 300
aaccctctcc aactgccctt caatttcacc tggccgggta ccttctcgct catcatcgaa 360
gcttggcacg cgccaggaga cgacctgcgg ccagaggcct tgccaccaga tgcactcatc 420
agcaagatcg ccatccaggg ctccctagct gtgggtcaga actggttatt ggatgagcaa 480
accagcaccc tcacaaggct gcgctactct taccgggtca tctgcagtga caactactat 540
ggagacaact gctcccgcct gtgcaagaag cgcaatgacc acttcggcca ctatgtgtgc 600
cagccagatg gcaacttgtc ctgcctgccc ggttggactg gggaatattg ccaacagcct 660
atctgtcttt cgggctgtca tgaacagaat ggctactgca gcaagccagc agagtgcctc 720
tgccgcccag gctggcaggg ccggctgtgt aacgaatgca tcccccacaa tggctgtcgc 780
cacggcacct gcagcactcc ctggcaatgt acttgtgatg agggctgggg aggcctgttt 840
tgtgaccaag atctcaacta ctgcacccac cactccccat gcaagaatgg ggcaacgtgc 900
tccaacagtg ggcagcgaag ctacacctgc acctgtcgcc caggctacac tggtgtggac 960
tgtgagctgg agctcagcga gtgtgacagc aacccctgtc gcaatggagg cagctgtaag 1020
gaccaggagg atggctacca ctgcctgtgt cctccgggct actatggcct gcattgtgaa 1080
cacagcacct tgagctgcgc cgactccccc tgcttcaatg ggggctcctg ccgggagcgc 1140
aaccaggggg ccaactatgc ttgtgaatgt ccccccaact tcaccggctc caactgcgag 1200
aagaaagtgg acaggtgcac cagcaacccc tgtgccaacg ggggacagtg cctgaaccga 1260
ggtccaagcc gcatgtgccg ctgccgtcct ggattcacgg gcacctactg tgaactccac 1320
gtcagcgact gtgcccgtaa cccttgcgcc cacggtggca cttgccatga cctggagaat 1380
gggctcatgt gcacctgccc tgccggcttc tctggccgac gctgtgaggt gcggacatcc 1440
atcgatgcct gtgcctcgag tccctgcttc aacagggcca cctgctacac cgacctctcc 1500
acagacacct ttgtgtgcaa ctgcccttat ggctttgtgg gcagccgctg cgagttcccc 1560
gtgggcttgc cgcccagctt cccctgggtg gccgtctcgc tgggtgtggg gctggcagtg 1620
ctgctggtac tgctgggcat ggtggcagtg gctgtgcggc agctgcggct tcgacggccg 1680
gacgacggca gcagggaagc catgaacaac ttgtcggact tccagaagga caacctgatt 1740
cctgccgccc agcttaaaaa cacaaaccag aagaaggagc tggaagtgga ctgtggcctg 1800
gacaagtcca actgtggcaa acagcaaaac cacacattgg actataatct ggccccaggg 1860
cccctggggc gggggaccat gccaggaaag tttccccaca gtgacaagag cttaggagag 1920
aaggcgccac tgcggttaca cagtgaaaag ccagagtgtc ggatatcagc gatatgctcc 1980
cccagggact ccatgtacca gtctgtgtgt ttgatatcag aggagaggaa tgaatgtgtc 2040
attgccacgg aggtataa                                               2058

<210> 2
<211> 685
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu
 1               5                  10                  15      
Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu
            20                  25                  30          
Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg
        35                  40                  45              
Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His
    50                  55                  60                  
Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser
65                  70                  75                  80  
Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser
                85                  90                  95      
Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro
            100                 105                 110         
Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp
        115                 120                 125             
Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala
    130                 135                 140                 
Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln
145                 150                 155                 160 
Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser
                165                 170                 175     
Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn
            180                 185                 190         
Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys
        195                 200                 205             
Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser
    210                 215                 220                 
Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu
225                 230                 235                 240 
Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His
                245                 250                 255     
Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys
            260                 265                 270         
Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys
        275                 280                 285             
Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly
    290                 295                 300                 
Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp
305                 310                 315                 320 
Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly
                325                 330                 335     
Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro
            340                 345                 350         
Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp
        355                 360                 365             
Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala
    370                 375                 380                 
Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu
385                 390                 395                 400 
Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln
                405                 410                 415     
Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe
            420                 425                 430         
Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro
        435                 440                 445             
Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys
    450                 455                 460                 
Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser
465                 470                 475                 480 
Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr
                485                 490                 495     
Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe
            500                 505                 510         
Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro
        515                 520                 525             
Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu
    530                 535                 540                 
Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro
545                 550                 555                 560 
Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys
                565                 570                 575     
Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys
            580                 585                 590         
Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln
        595                 600                 605             
Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg
    610                 615                 620                 
Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu
625                 630                 635                 640 
Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser
                645                 650                 655     
Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile
            660                 665                 670         
Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val
        675                 680                 685 


<210> 3
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 3
caggtgcagc tggtgcagtc aggtccagga ctggtgaagc cctcgcagaa cctctcactc 60
acctgtgcca tctccggaga cagtgtctct agtgatagtg ctgcttggaa ctggatcagg 120
cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat 180
aatgattatg cagtatctgt gaaaagtcga ataaccttca acccagatac atccaagaac 240
cacatctccc tgcagctgaa ctctgtgact cccgaggaca cggctatcta ttactgtgca 300
agagaggggg ataattggaa ttacggctgg ctcgacccct ggggccaggg aaccacggtc 360
accgtctcct ca                                                     372

<210> 4
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 4
Gln Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Asn Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asp
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
        35                  40                  45              
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Thr Phe Asn Pro Asp Thr Ser Lys Asn
65                  70                  75                  80  
His Ile Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Ile
                85                  90                  95      
Tyr Tyr Cys Ala Arg Glu Gly Asp Asn Trp Asn Tyr Gly Trp Leu Asp
            100                 105                 110         
Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 5
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 5
ggagacagtg tctctagtga tagtgctgct                                  30

<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 6
Gly Asp Ser Val Ser Ser Asp Ser Ala Ala
 1               5                  10  


<210> 7
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 7
acatactaca ggtccaagtg gtataat                                     27

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 8
Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn
 1               5                  


<210> 9
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 9
gcaagagagg gggataattg gaattacggc tggctcgacc cc                    42

<210> 10
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 10
Ala Arg Glu Gly Asp Asn Trp Asn Tyr Gly Trp Leu Asp Pro
 1               5                  10                  


<210> 11
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 11
gacatccagt tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60
atctcctgca ggtctagtca gagcctcctt cttagtaatg gatacaacta tttggattgg 120
tacctgcaga agccagggca gtctccacaa ctcctgatct atttggtttc tagtcgggcc 180
tccggggtcc ctgacaggtt cagtggcagt ggatccggca cagattttac actgaaaatc 240
agcagagtgg aggctgagga ttttggaatt tattattgta tgcaagctct acaaactccg 300
tacacttttg gccgggggac caaggtggaa atcaaa                           336

<210> 12
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 12
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Val Ser Ser Arg Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Phe Gly Ile Tyr Tyr Cys Met Gln Ala
                85                  90                  95      
Leu Gln Thr Pro Tyr Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys
            100                 105                 110         


<210> 13
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 13
cagagcctcc ttcttagtaa tggatacaac tat                              33

<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 14
Gln Ser Leu Leu Leu Ser Asn Gly Tyr Asn Tyr
 1               5                  10      


<210> 15
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 15
ttggtttct                                                         9

<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 16
Leu Val Ser
 1          


<210> 17
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 17
atgcaagctc tacaaactcc gtacact                                     27

<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 18
Met Gln Ala Leu Gln Thr Pro Tyr Thr
 1               5                  


<210> 19
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 19
gaggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtgtcattt ttatggtatg atggaactaa taaaaactat 180
gtagagtccg tgaagggccg attcaccatc tcaagagaca attccaagaa tatgctgtat 240
ctggaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300
gattttagga gtggttatga ggggtggttc gacccctggg gccagggaac cctggtcacc 360
gtctcctca                                                         369

<210> 20
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 20
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Phe Leu Trp Tyr Asp Gly Thr Asn Lys Asn Tyr Val Glu Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Asp Phe Arg Ser Gly Tyr Glu Gly Trp Phe Asp Pro
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 21
ggattcacct tcagtagtta tggc                                        24

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 22
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 23
ttatggtatg atggaactaa taaa                                        24

<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 24
Leu Trp Tyr Asp Gly Thr Asn Lys
 1               5              


<210> 25
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 25
gcgagagatc acgattttag gagtggttat gaggggtggt tcgacccc              48

<210> 26
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 26
Ala Arg Asp His Asp Phe Arg Ser Gly Tyr Glu Gly Trp Phe Asp Pro
 1               5                  10                  15      


<210> 27
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 27
gaaatagtga tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct 120
ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240
gaagattttg cagtttatta ctgtcaacac cgtagcaact ggcctcccac tttcggcgga 300
gggaccaagg tggaaatcaa a                                           321

<210> 28
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 28
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 29
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 29
cagagtgtta gcagctac                                               18

<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 30
Gln Ser Val Ser Ser Tyr
 1               5      


<210> 31
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 31
gatgcatcc                                                         9

<210> 32
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 32
Asp Ala Ser
 1          


<210> 33
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 33
caacaccgta gcaactggcc tcccact                                     27

<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 34
Gln His Arg Ser Asn Trp Pro Pro Thr
 1               5                  


<210> 35
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 35
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc 60
acctgcactg tctctgatgg ctccatcaac agtgttgaat cctactggac ctggatccgc 120
cagcacccag ggaagggcct ggagtggatt ggatacatca aatacactgg gggcatccac 180
tataacccgt ccctcaagag tcgacttgcc atatcagtgg acacgtcaaa gaaccagttc 240
tccctgaaaa tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagca 300
cgtggaagtc atacttttga tgtctggggc caggggacaa tggtcaccgt ctcttca    357

<210> 36
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 36
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Gly Ser Ile Asn Ser Val
            20                  25                  30          
Glu Ser Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Tyr Ile Lys Tyr Thr Gly Gly Ile His Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Ala Arg Gly Ser His Thr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 37
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 37
gatggctcca tcaacagtgt tgaatcctac                                  30

<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 38
Asp Gly Ser Ile Asn Ser Val Glu Ser Tyr
 1               5                  10  


<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 39
atcaaataca ctgggggcat c                                           21

<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 40
Ile Lys Tyr Thr Gly Gly Ile
 1               5          


<210> 41
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 41
gcgagagcac gtggaagtca tacttttgat gtc                              33

<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 42
Ala Arg Ala Arg Gly Ser His Thr Phe Asp Val
 1               5                  10      


<210> 43
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 43
gaaattgtgc tgactcagtc tccaggcacc ctgtcttggt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattagc agtaactact tagcctggta ccagcagaaa 120
cctggccagg ctcccagact cctcatttat ggtgcatcca gcagggtcac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttgcactgta ttattgtcag cagtatagta ggtcaccgat caccttcggc 300
caagggacca aagtggatat caaa                                        324

<210> 44
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 44
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Trp Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Val Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Ser Arg Ser Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
            100                 105             


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 45
cagagtatta gcagtaacta c                                           21

<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 46
Gln Ser Ile Ser Ser Asn Tyr
 1               5          


<210> 47
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 47
ggtgcatcc                                                         9

<210> 48
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 48
Gly Ala Ser
 1          


<210> 49
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 49
cagcagtata gtaggtcacc gatcacc                                     27

<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 50
Gln Gln Tyr Ser Arg Ser Pro Ile Thr
 1               5                  


<210> 51
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 51
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc 60
acctgcactg tctctggtgg ctccatcaac agtgttactt actactggac ctggatccgc 120
cagcacccag ggaggggcct agagtggatt gggtacatca aattcagtgg gagcacctac 180
tacaacccgt ccctcaaggg tcgagtcacc atatcagtgg acacgtctaa gaaccaattc 240
tcccttaaaa ttaactctgt gactgccgcg gacacggccg tgttttactg tgcgagagct 300
tctggaagtc atacttttga tatctggggc caagggacaa tggtcaccgt ctcctca    357

<210> 52
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 52
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Val
            20                  25                  30          
Thr Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Arg Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Tyr Ile Lys Phe Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Ile Asn Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr
                85                  90                  95      
Cys Ala Arg Ala Ser Gly Ser His Thr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 53
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 53
ggtggctcca tcaacagtgt tacttactac                                  30

<210> 54
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 54
Gly Gly Ser Ile Asn Ser Val Thr Tyr Tyr
 1               5                  10  


<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 55
atcaaattca gtgggagcac c                                           21

<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 56
Ile Lys Phe Ser Gly Ser Thr
 1               5          


<210> 57
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 57
gcgagagctt ctggaagtca tacttttgat atc                              33

<210> 58
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 58
Ala Arg Ala Ser Gly Ser His Thr Phe Asp Ile
 1               5                  10      


<210> 59
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 59
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc aacagctact tagcctggta ccagcagaaa 120
cctggccagg ctcccaggct cctcatctct ggtgcgtcca gcagggtcac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttggaatgta ttactgtcag cagtatagta ggtcaccgat caccttcggc 300
caagggacca agctggagat caaa                                        324

<210> 60
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 60
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Ser Gly Ala Ser Ser Arg Val Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Gly Met Tyr Tyr Cys Gln Gln Tyr Ser Arg Ser Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 61
cagagtgtta gcaacagcta c                                           21

<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 62
Gln Ser Val Ser Asn Ser Tyr
 1               5          


<210> 63
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 63
ggtgcgtcc                                                         9

<210> 64
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 64
Gly Ala Ser
 1          


<210> 65
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 65
cagcagtata gtaggtcacc gatcacc                                     27

<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 66
Gln Gln Tyr Ser Arg Ser Pro Ile Thr
 1               5                  


<210> 67
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 67
gaagtgcagc tggtgcagtc tgggggagcc ttggtacaac ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttaac aactttgcca tgacctgggt ccgccaggct 120
ccagggaagg gcctggagtg ggtctcaact attagtggta gtggcgttga cacatactgc 180
gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacactgtat 240
ctgcaaatga acagcctgag agccgaggac acggccgtat attactgttc gaaagatggc 300
gccttctata gtggctacga acactactgg ggccagggaa ccacggtcac cgtctcctca 360


<210> 68
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 68
Glu Val Gln Leu Val Gln Ser Gly Gly Ala Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Phe
            20                  25                  30          
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Ser Gly Ser Gly Val Asp Thr Tyr Cys Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Lys Asp Gly Ala Phe Tyr Ser Gly Tyr Glu His Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser
        115                 120 


<210> 69
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 69
ggattcacct ttaacaactt tgcc                                        24

<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 70
Gly Phe Thr Phe Asn Asn Phe Ala
 1               5              


<210> 71
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 71
attagtggta gtggcgttga caca                                        24

<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 72
Ile Ser Gly Ser Gly Val Asp Thr
 1               5              


<210> 73
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 73
tcgaaagatg gcgccttcta tagtggctac gaacactac                        39

<210> 74
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 74
Ser Lys Asp Gly Ala Phe Tyr Ser Gly Tyr Glu His Tyr
 1               5                  10              


<210> 75
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 75
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120
cctggccagg ctcccaggct cctcatctat ggtacatcca acagggccac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
tctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcg gacgttcggc 300
caagggacca aggtggagat caaa                                        324

<210> 76
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 76
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Thr Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95      
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 77
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 77
cagagtgtta gcagcagcta c                                           21

<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 78
Gln Ser Val Ser Ser Ser Tyr
 1               5          


<210> 79
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 79
ggtacatcc                                                         9

<210> 80
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 80
Gly Thr Ser
 1          


<210> 81
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 81
cagcagtatg gtagctcacc tcggacg                                     27

<210> 82
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 82
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
 1               5                  


<210> 83
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 83
gaagtgcagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggtta cacctttacc tactatggta tcagttggat acgacagacc 120
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acgatggtaa cacagactat 180
gcacagaagt tccaagacag aatcaccatg accacagaca catcctcgac cacagcctac 240
atggaactga ggagcctgag atctgacgac acggccgtct attactgtgc gaggtatagt 300
tggaacaagc actggttcga cccctggggc cagggaacca tggtcaccgt ctcttca    357

<210> 84
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 84
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Tyr
            20                  25                  30          
Gly Ile Ser Trp Ile Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asp Gly Asn Thr Asp Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Asp Arg Ile Thr Met Thr Thr Asp Thr Ser Ser Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Ser Trp Asn Lys His Trp Phe Asp Pro Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 85
ggttacacct ttacctacta tggt                                        24

<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 86
Gly Tyr Thr Phe Thr Tyr Tyr Gly
 1               5              


<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 87
atcagcgctt acgatggtaa caca                                        24

<210> 88
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 88
Ile Ser Ala Tyr Asp Gly Asn Thr
 1               5              


<210> 89
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 89
gcgaggtata gttggaacaa gcactggttc gacccc                           36

<210> 90
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 90
Ala Arg Tyr Ser Trp Asn Lys His Trp Phe Asp Pro
 1               5                  10          


<210> 91
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 91
gaaattgtga tgacacagtc tccaggcacc ctgtctttgt ctccagggga cagagccacc 60
ctctcctgca gggccagtca gagtgttacc ggcagctact tagcctggta ccagcagaaa 120
cctggccagg ctcccagact cctcatctat ggtgcatcca acagggccac tggcatccca 180
gacaggttca ctggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttgcagtgta tttctgtcaa cagtctgctt tctcaccgtg gacgttcggc 300
caggggacca aggtggaaat caaa                                        324

<210> 92
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 92
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Gly Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Thr
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Ala Phe Ser Pro
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 93
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 93
cagagtgtta ccggcagcta c                                           21

<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 94
Gln Ser Val Thr Gly Ser Tyr
 1               5          


<210> 95
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 95
ggtgcatcc                                                         9

<210> 96
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 96
Gly Ala Ser
 1          


<210> 97
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 97
caacagtctg ctttctcacc gtggacg                                     27

<210> 98
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 98
Gln Gln Ser Ala Phe Ser Pro Trp Thr
 1               5                  


<210> 99
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 99
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc 60
acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ttggatccgc 120
cagcacccag ggaagggcct ggagtggatt gggtacatcc attatagtgg gaacacccac 180
tacaatccga ccctcaagag tcgaattacc atatcagtag acacgtctaa gaaccagttc 240
tcccttgagg tgaactctgt gactgccgcg gacacggccg tatactactg tgcgaggaat 300
atggttcggg gagttcactg gttcgacccc tggggccagg gaaccacggt caccgtctcc 360
tca                                                               363

<210> 100
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 100
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Tyr Ile His Tyr Ser Gly Asn Thr His Tyr Asn Pro Thr
    50                  55                  60                  
Leu Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Glu Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Asn Met Val Arg Gly Val His Trp Phe Asp Pro Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 101
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 101
ggtggctcca tcagcagtgg tggttactac                                  30

<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 102
Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr
 1               5                  10  


<210> 103
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 103
atccattata gtgggaacac c                                           21

<210> 104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 104
Ile His Tyr Ser Gly Asn Thr
 1               5          


<210> 105
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 105
gcgaggaata tggttcgggg agttcactgg ttcgacccc                        39

<210> 106
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 106
Ala Arg Asn Met Val Arg Gly Val His Trp Phe Asp Pro
 1               5                  10              


<210> 107
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 107
gaaatagtgt tgacacagtc tccaggcacc ctgtctttgt ctccagggga gagagccacc 60
ctcttctgtt gggccagtcg gagtgttagc agcagctact tagcctggta ccagcagaaa 120
cctggccagg ctcccaggct cctcatctct ggtgcatcca gcagggccac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttgcagtata tttctgtcaa cagtatagta gttcaccgct cactttcggc 300
ggagggacca agctggagat caaa                                        324

<210> 108
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 108
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Phe Cys Trp Ala Ser Arg Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Ser Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ser Ser Ser Pro
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 109
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 109
cggagtgtta gcagcagcta c                                           21

<210> 110
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 110
Arg Ser Val Ser Ser Ser Tyr
 1               5          


<210> 111
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 111
ggtgcatcc                                                         9

<210> 112
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 112
Gly Ala Ser
 1          


<210> 113
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 113
caacagtata gtagttcacc gctcact                                     27

<210> 114
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 114
Gln Gln Tyr Ser Ser Ser Pro Leu Thr
 1               5                  


<210> 115
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 115
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtgtcattt ttatggtatg atggaactaa taaaaactat 180
gtagagtccg tgaagggccg attcaccatc tcaagagaca attccaagaa tatgctgtat 240
ctggaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300
gattttagga gtggttatga ggggtggttc gacccctggg gccagggaac cctggtcacc 360
gtctcctca                                                         369

<210> 116
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 116
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Phe Leu Trp Tyr Asp Gly Thr Asn Lys Asn Tyr Val Glu Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Asp Phe Arg Ser Gly Tyr Glu Gly Trp Phe Asp Pro
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 117
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 117
gaaatagtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct 120
ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240
gaagattttg cagtttatta ctgtcaacac cgtagcaact ggcctcccac tttcggcgga 300
gggaccaagg tggaaatcaa a                                           321

<210> 118
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 118
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         

