                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique (CNRS)
      
 
<120>  Method for testing a subject thought to be predisposed to having metastatic cancer

<130>  D27629


<150>  EP 09305633.1  
       US 61/221,769

<151>  2009-06-30


<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  209
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein delta133p53beta (Genbank NM 
       001126116.1)

<400>  1

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  2
<211>  2404
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein delta133p53beta (Genbank NM 
       001126116.1)

<400>  2
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag     60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag    120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct    180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct    240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga    300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca    360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg    420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa    480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct    540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca    600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact    660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga    720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc    780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga    840

agaaaccact ggatggagaa tatttcaccc ttcaggacca gaccagcttt caaaaagaaa    900

attgttaaag agagcatgaa aatggttcta tgactttgcc tgatacagat gctacttgac    960

ttacgatggt gttacttcct gataaactcg tcgtaagttg aaaatattat ccgtgggcgt   1020

gagcgcttcg agatgttccg agagctgaat gaggccttgg aactcaagga tgcccaggct   1080

gggaaggagc caggggggag cagggctcac tccagccacc tgaagtccaa aaagggtcag   1140

tctacctccc gccataaaaa actcatgttc aagacagaag ggcctgactc agactgacat   1200

tctccacttc ttgttcccca ctgacagcct cccaccccca tctctccctc ccctgccatt   1260

ttgggttttg ggtctttgaa cccttgcttg caataggtgt gcgtcagaag cacccaggac   1320

ttccatttgc tttgtcccgg ggctccactg aacaagttgg cctgcactgg tgttttgttg   1380

tggggaggag gatggggagt aggacatacc agcttagatt ttaaggtttt tactgtgagg   1440

gatgtttggg agatgtaaga aatgttcttg cagttaaggg ttagtttaca atcagccaca   1500

ttctaggtag gggcccactt caccgtacta accagggaag ctgtccctca ctgttgaatt   1560

ttctctaact tcaaggccca tatctgtgaa atgctggcat ttgcacctac ctcacagagt   1620

gcattgtgag ggttaatgaa ataatgtaca tctggccttg aaaccacctt ttattacatg   1680

gggtctagaa cttgaccccc ttgagggtgc ttgttccctc tccctgttgg tcggtgggtt   1740

ggtagtttct acagttgggc agctggttag gtagagggag ttgtcaagtc tctgctggcc   1800

cagccaaacc ctgtctgaca acctcttggt gaaccttagt acctaaaagg aaatctcacc   1860

ccatcccaca ccctggagga tttcatctct tgtatatgat gatctggatc caccaagact   1920

tgttttatgc tcagggtcaa tttctttttt cttttttttt tttttttttc tttttctttg   1980

agactgggtc tcgctttgtt gcccaggctg gagtggagtg gcgtgatctt ggcttactgc   2040

agcctttgcc tccccggctc gagcagtcct gcctcagcct ccggagtagc tgggaccaca   2100

ggttcatgcc accatggcca gccaactttt gcatgttttg tagagatggg gtctcacagt   2160

gttgcccagg ctggtctcaa actcctgggc tcaggcgatc cacctgtctc agcctcccag   2220

agtgctggga ttacaattgt gagccaccac gtccagctgg aagggtcaac atcttttaca   2280

ttctgcaagc acatctgcat tttcacccca cccttcccct ccttctccct ttttatatcc   2340

catttttata tcgatctctt attttacaat aaaactttgc tgccacctgt gtgtctgagg   2400

ggtg                                                                2404


<210>  3
<211>  261
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein delta133p53 (Genbank NM 001126115.1)

<400>  3

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  4
<211>  2271
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein delta133p53 (Genbank NM 001126115.1)

<400>  4
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag     60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag    120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct    180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct    240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga    300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca    360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg    420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa    480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct    540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca    600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact    660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga    720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc    780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga    840

agaaaccact ggatggagaa tatttcaccc ttcagatccg tgggcgtgag cgcttcgaga    900

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag    960

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc   1020

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg   1080

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt   1140

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt   1200

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat   1260

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga   1320

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg   1380

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca   1440

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt   1500

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt   1560

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca   1620

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg   1680

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc   1740

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca   1800

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg   1860

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc   1920

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc   1980

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg   2040

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta   2100

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca   2160

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg   2220

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g            2271


<210>  5
<211>  214
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein delta133p53gamma (Genbank NM 
       001126117.1)

<400>  5

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  6
<211>  2331
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein p53, delta133p53gamma (Genbank NM 
       001126117.1)

<400>  6
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag     60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag    120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct    180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct    240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga    300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca    360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg    420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa    480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct    540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca    600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact    660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga    720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc    780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga    840

agaaaccact ggatggagaa tatttcaccc ttcagatgct acttgactta cgatggtgtt    900

acttcctgat aaactcgtcg taagttgaaa atattatccg tgggcgtgag cgcttcgaga    960

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag   1020

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc   1080

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg   1140

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt   1200

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt   1260

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat   1320

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga   1380

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg   1440

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca   1500

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt   1560

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt   1620

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca   1680

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg   1740

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc   1800

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca   1860

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg   1920

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc   1980

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc   2040

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg   2100

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta   2160

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca   2220

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg   2280

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g            2331


<210>  7
<211>  393
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein p53 (Genbank NM 000546.4)

<400>  7

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  8
<211>  2586
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens tumor protein p53 (Genbank NM 000546.4)

<400>  8
gattggggtt ttcccctccc atgtgctcaa gactggcgct aaaagttttg agcttctcaa     60

aagtctagag ccaccgtcca gggagcaggt agctgctggg ctccggggac actttgcgtt    120

cgggctggga gcgtgctttc cacgacggtg acacgcttcc ctggattggc agccagactg    180

ccttccgggt cactgccatg gaggagccgc agtcagatcc tagcgtcgag ccccctctga    240

gtcaggaaac attttcagac ctatggaaac tacttcctga aaacaacgtt ctgtccccct    300

tgccgtccca agcaatggat gatttgatgc tgtccccgga cgatattgaa caatggttca    360

ctgaagaccc aggtccagat gaagctccca gaatgccaga ggctgctccc cccgtggccc    420

ctgcaccagc agctcctaca ccggcggccc ctgcaccagc cccctcctgg cccctgtcat    480

cttctgtccc ttcccagaaa acctaccagg gcagctacgg tttccgtctg ggcttcttgc    540

attctgggac agccaagtct gtgacttgca cgtactcccc tgccctcaac aagatgtttt    600

gccaactggc caagacctgc cctgtgcagc tgtgggttga ttccacaccc ccgcccggca    660

cccgcgtccg cgccatggcc atctacaagc agtcacagca catgacggag gttgtgaggc    720

gctgccccca ccatgagcgc tgctcagata gcgatggtct ggcccctcct cagcatctta    780

tccgagtgga aggaaatttg cgtgtggagt atttggatga cagaaacact tttcgacata    840

gtgtggtggt gccctatgag ccgcctgagg ttggctctga ctgtaccacc atccactaca    900

actacatgtg taacagttcc tgcatgggcg gcatgaaccg gaggcccatc ctcaccatca    960

tcacactgga agactccagt ggtaatctac tgggacggaa cagctttgag gtgcgtgttt   1020

gtgcctgtcc tgggagagac cggcgcacag aggaagagaa tctccgcaag aaaggggagc   1080

ctcaccacga gctgccccca gggagcacta agcgagcact gcccaacaac accagctcct   1140

ctccccagcc aaagaagaaa ccactggatg gagaatattt cacccttcag atccgtgggc   1200

gtgagcgctt cgagatgttc cgagagctga atgaggcctt ggaactcaag gatgcccagg   1260

ctgggaagga gccagggggg agcagggctc actccagcca cctgaagtcc aaaaagggtc   1320

agtctacctc ccgccataaa aaactcatgt tcaagacaga agggcctgac tcagactgac   1380

attctccact tcttgttccc cactgacagc ctcccacccc catctctccc tcccctgcca   1440

ttttgggttt tgggtctttg aacccttgct tgcaataggt gtgcgtcaga agcacccagg   1500

acttccattt gctttgtccc ggggctccac tgaacaagtt ggcctgcact ggtgttttgt   1560

tgtggggagg aggatgggga gtaggacata ccagcttaga ttttaaggtt tttactgtga   1620

gggatgtttg ggagatgtaa gaaatgttct tgcagttaag ggttagttta caatcagcca   1680

cattctaggt aggggcccac ttcaccgtac taaccaggga agctgtccct cactgttgaa   1740

ttttctctaa cttcaaggcc catatctgtg aaatgctggc atttgcacct acctcacaga   1800

gtgcattgtg agggttaatg aaataatgta catctggcct tgaaaccacc ttttattaca   1860

tggggtctag aacttgaccc ccttgagggt gcttgttccc tctccctgtt ggtcggtggg   1920

ttggtagttt ctacagttgg gcagctggtt aggtagaggg agttgtcaag tctctgctgg   1980

cccagccaaa ccctgtctga caacctcttg gtgaacctta gtacctaaaa ggaaatctca   2040

ccccatccca caccctggag gatttcatct cttgtatatg atgatctgga tccaccaaga   2100

cttgttttat gctcagggtc aatttctttt ttcttttttt tttttttttt tctttttctt   2160

tgagactggg tctcgctttg ttgcccaggc tggagtggag tggcgtgatc ttggcttact   2220

gcagcctttg cctccccggc tcgagcagtc ctgcctcagc ctccggagta gctgggacca   2280

caggttcatg ccaccatggc cagccaactt ttgcatgttt tgtagagatg gggtctcaca   2340

gtgttgccca ggctggtctc aaactcctgg gctcaggcga tccacctgtc tcagcctccc   2400

agagtgctgg gattacaatt gtgagccacc acgtccagct ggaagggtca acatctttta   2460

cattctgcaa gcacatctgc attttcaccc cacccttccc ctccttctcc ctttttatat   2520

cccattttta tatcgatctc ttattttaca ataaaacttt gctgccacct gtgtgtctga   2580

ggggtg                                                              2586


<210>  9
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer DNp53-228F for the detection of  delta133p53,  
       delta133p53beta and  delta133p53gamma

<400>  9
actctgtctc cttcctcttc ctacag                                          26


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer JWR for the detection of  delta133p53,  
       delta133p53beta and  delta133p53gamma

<400>  10
gtgtggaatc aacccacagc t                                               21


<210>  11
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  p53 probe for the detection of  delta133p53,  delta133p53beta and
       delta133p53gamma

<400>  11
tcccctgccc tcaacaagat gttttgcc                                        28





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