                         SEQUENCE LISTING

<110>  AVIR GREEN HILLS BIOTECHNOLOGY RESEARCH DEVELOPMENT TRADE 
       AG
 
<120>  Novel influenza virus

<130>  GH009P

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  2341
<212>  DNA
<213>  Influenza virus

<400>  1
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttgaaaatt     60

ccagcgcaaa atgccataag caccacattc ccttatactg gagatcctcc atacagccat    120

ggaacaggaa caggatacac catggacaca gttaacagaa cacatcaata ttcagaaaaa    180

gggaaatgga caacaaacac agaaactggg gcgccccaac ttaacccgat tgatggacca    240

ctacctgagg ataatgagcc aagtggatat gcacaaacag actgtgtcct ggaagctatg    300

gctttccttg aggaatccca cccagggatc tttgaaaact cgtgccttga aacaatggaa    360

gtcgttcaac aaacaagagt ggacagactg acccaaggtc gtcagaccta tgattggaca    420

ttaaacagaa atcaaccagc cgcaactgca ttagccaaca ctatagaagt tttcagatcg    480

aatggtctaa cagctaatga gtcgggaagg ctaatagatt tcctcaagga tgtgatggaa    540

tcaatggata aagaggaaat agagataaca acacacttcc aaagaaaaag aagagtaaga    600

gacaacatga ccaagaaaat ggtcacacaa agaacaatag gaaagaaaaa gcagagagtg    660

aacaagagaa gctatctaat aagagcatta actttgaaca caatgaccaa agatgcagaa    720

agaggtaaat taaagagaag agctattgca acacccggga tgcaaatcag agggttcgtg    780

tactttgttg aaactctagc taggagcatt tgtgagaagc ttgaacagtc tggacttcca    840

gtaggaggta atgaaaagaa ggccaaactg gcaaatgttg tgagaaagat gatgactaat    900

tcacaagaca cagagctttc tttcacaatt actggagaca atactaagtg gaatgaaaat    960

caaaatcctc gaatgttcct ggcgatgatt acatatatca caaaaaatca acctgaatgg   1020

ttcagaaaca tcctgagcat cgcacccata atgttctcaa acaaaatggc gagactaggg   1080

aaaggataca tgttcgaaag taagagaatg aagctccgaa cacaaatacc agcagaaatg   1140

ctagcaagca ttgacctaaa gtatttcaat gaatcaacaa gaaagaaaat tgagaaaata   1200

aggcctcttc taatagatgg cacagcgtca ttgagccctg gaatgatgat gggcatgttc   1260

aacatgctaa gtacggtttt aggagtctca atactgaatc ttgggcaaaa gaaatacacc   1320

aaaacaacat actggtggga tgggcttcaa tcctctgatg attttgctct catagtgaat   1380

gcaccaaatc atgagggaat acaagcagga gtggatagat tctacagaac ctgcaagcta   1440

gtcggaatca atatgagcaa gaagaagtcc tatataaata ggacaggaac atttgaattc   1500

acaagctttt tttatcgcta tggatttgtg gccaatttta gcatggagct gcccagtttt   1560

ggagtgtctg ggattaatga atcagctgat atgagcattg gagtaacagt gataaagaac   1620

aacatgataa acaatgacct tggaccagca acagcccaga tggctcttca actgttcatc   1680

aaggactaca gatatacata tcggtgccac agaggagaca cacaaattca gacgaggaga   1740

tcatttgagc taaagaagct gtgggagcaa acccgatcaa aggcaggact attggtttca   1800

gatggaggac cgaacttata caatatccgg aatcttcaca tccctgaagt ctgcttaaag   1860

tgggagctaa tggatgaaga ctatcaggga agactttgta atcccctgaa tccatttgtc   1920

agccataaag agattgagtc tgtaaacaat gctgtggtaa tgccagctca tggtccagcc   1980

aagagcatgg aatatgacgc tgttgcaact acacactcct ggattcccaa gaggaaccgc   2040

tctattctca acacaagcca aaggggaatt cttgaggatg aacagatgta tcagaagtgc   2100

tgcaacctgt tcgagaaatt tttccccagt agttcataca ggagaccggt tggaatttcc   2160

agcatggtgg aggccatggt gtctagggcc cggattgatg ccagaattga cttcgagtct   2220

ggacggatta agaaagaaga gttctccgag atcatgaaga tctgttccac cattgaagag   2280

ctcagacggc aaaaacaatg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac   2340

t                                                                   2341


<210>  2
<211>  2341
<212>  DNA
<213>  artificial

<220>
<223>  influenza virus with modified PB1 gene (GHB01 PBdelF2)

<400>  2
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttgaaaatt     60

ccagcgcaaa atgccataag caccacattc ccttatactg gagatcctcc atacagccac    120

ggaacaggaa caggatacac catggacaca gtgaacagaa cacatcaata ttcagaaaaa    180

gggaaatgga caacaaacac agaaactggg gcgccccaac taaacccgat tgacggacca    240

ctacctgagg ataacgagcc aagtggatac gcacaaacag actgtgtcct agaagctatg    300

gctttccttg aggaatccca cccagggatc tttgaaaact cgtgccttga aacaatggaa    360

gtcgttcaac aaacaagagt ggacagactg acccaaggtc gtcagaccta tgattggaca    420

ttaaacagaa atcaaccagc cgcaactgca ttagccaaca ctatagaagt tttcagatcg    480

aatggtctaa cagctaatga gtcgggaagg ctaatagatt tcctcaagga tgtgatggaa    540

tcaatggata aagaggaaat agagataaca acacacttcc aaagaaaaag aagagtaaga    600

gacaacatga ccaagaaaat ggtcacacaa agaacaatag gaaagaaaaa gcagagagtg    660

aacaagagaa gctatctaat aagagcatta actttgaaca caatgaccaa agatgcagaa    720

agaggtaaat taaagagaag agctattgca acacccggga tgcaaatcag agggttcgtg    780

tactttgttg aaactctagc taggagcatt tgtgagaagc ttgaacagtc tggacttcca    840

gtaggaggta atgaaaagaa ggccaaactg gcaaatgttg tgagaaagat gatgactaat    900

tcacaagaca cagagctttc tttcacaatt actggagaca atactaagtg gaatgaaaat    960

caaaatcctc gaatgttcct ggcgatgatt acatatatca caaaaaatca acctgaatgg   1020

ttcagaaaca tcctgagcat cgcacccata atgttctcaa acaaaatggc gagactaggg   1080

aaaggataca tgttcgaaag taagagaatg aagctccgaa cacaaatacc agcagaaatg   1140

ctagcaagca ttgacctaaa gtatttcaat gaatcaacaa gaaagaaaat tgagaaaata   1200

aggcctcttc taatagatgg cacagcgtca ttgagccctg gaatgatgat gggcatgttc   1260

aacatgctaa gtacggtttt aggagtctca atactgaatc ttgggcaaaa gaaatacacc   1320

aaaacaacat actggtggga tgggcttcaa tcctctgatg attttgctct catagtgaat   1380

gcaccaaatc atgagggaat acaagcagga gtggatagat tctacagaac ctgcaagcta   1440

gtcggaatca atatgagcaa gaagaagtcc tatataaata ggacaggaac atttgaattc   1500

acaagctttt tttatcgcta tggatttgtg gccaatttta gcatggagct gcccagtttt   1560

ggagtgtctg ggattaatga atcagctgat atgagcattg gagtaacagt gataaagaac   1620

aacatgataa acaatgacct tggaccagca acagcccaga tggctcttca actgttcatc   1680

aaggactaca gatatacata tcggtgccac agaggagaca cacaaattca gacgaggaga   1740

tcatttgagc taaagaagct gtgggagcaa acccgatcaa aggcaggact attggtttca   1800

gatggaggac cgaacttata caatatccgg aatcttcaca tccctgaagt ctgcttaaag   1860

tgggagctaa tggatgaaga ctatcaggga agactttgta atcccctgaa tccatttgtc   1920

agccataaag agattgagtc tgtaaacaat gctgtggtaa tgccagctca tggtccagcc   1980

aagagcatgg aatatgacgc tgttgcaact acacactcct ggattcccaa gaggaaccgc   2040

tctattctca acacaagcca aaggggaatt cttgaggatg aacagatgta tcagaagtgc   2100

tgcaacctgt tcgagaaatt tttccccagt agttcataca ggagaccggt tggaatttcc   2160

agcatggtgg aggccatggt gtctagggcc cggattgatg ccagaattga cttcgagtct   2220

ggacggatta agaaagaaga gttctccgag atcatgaaga tctgttccac cattgaagag   2280

ctcagacggc aaaaacaatg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac   2340

t                                                                   2341


<210>  3
<211>  90
<212>  PRT
<213>  Influenza Virus

<400>  3

Met Glu Gln Glu Gln Asp Thr Pro Trp Thr Gln Leu Thr Glu His Ile 
1               5                   10                  15      


Asn Ile Gln Lys Lys Gly Asn Gly Gln Gln Thr Gln Lys Leu Gly Arg 
            20                  25                  30          


Pro Asn Leu Thr Arg Leu Met Asp His Tyr Leu Arg Ile Met Ser Gln 
        35                  40                  45              


Val Asp Met His Lys Gln Thr Val Ser Trp Lys Leu Trp Leu Ser Leu 
    50                  55                  60                  


Arg Asn Pro Thr Gln Gly Ser Leu Lys Thr Arg Ala Leu Lys Gln Trp 
65                  70                  75                  80  


Lys Ser Phe Asn Lys Gln Glu Trp Thr Asp 
                85                  90  


<210>  4
<211>  91
<212>  PRT
<213>  artificial

<220>
<223>  mutant PB1F2 protein of influenza virus (GHB01 delF2)


<220>
<221>  X
<222>  (12)..(12)
<223>  X = TGA

<220>
<221>  X
<222>  (35)..(35)
<223>  X = TAA

<220>
<221>  X
<222>  (58)..(58)
<223>  X = TAG

<220>
<221>  X
<222>  (91)..(91)
<223>  X = TGA

<400>  4

Thr Glu Gln Glu Gln Asp Thr Pro Trp Thr Gln Xaa Thr Glu His Ile 
1               5                   10                  15      


Asn Ile Gln Lys Lys Gly Asn Gly Gln Gln Thr Gln Lys Leu Gly Arg 
            20                  25                  30          


Pro Asn Xaa Thr Arg Leu Thr Asp His Tyr Leu Arg Ile Thr Ser Gln 
        35                  40                  45              


Val Asp Thr His Lys Gln Thr Val Ser Xaa Lys Leu Trp Leu Ser Leu 
    50                  55                  60                  


Arg Asn Pro Thr Gln Gly Ser Leu Lys Thr Arg Ala Leu Lys Gln Trp 
65                  70                  75                  80  


Lys Ser Phe Asn Lys Gln Glu Trp Thr Asp Xaa 
                85                  90      


