                         SEQUENCE LISTING

<110>  INSTITUT GUSTAVE-ROUSSY
 
<120>  PARP AND ADJUVANT CISPLATIN-BASED CHEMOTHERAPY IN NON-SMALL-CELL 
       LUNG CANCER

<130>  D27730

<150>  US 61/228.341
<151>  2009-07-24

<160>  13    

<170>  PatentIn version 3.3

<210>  1
<211>  1014
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 
1               5                   10                  15      

Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 
            20                  25                  30          

Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 
        35                  40                  45              

Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 
    50                  55                  60                  

Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 
65                  70                  75                  80  

Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 
                85                  90                  95      

Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 
            100                 105                 110         

Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 
        115                 120                 125             

Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 
    130                 135                 140                 

Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 
145                 150                 155                 160 

Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 
                165                 170                 175     

Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 
            180                 185                 190         

Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 
        195                 200                 205             

Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 
    210                 215                 220                 

Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 
225                 230                 235                 240 

Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 
                245                 250                 255     

Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 
            260                 265                 270         

Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 
        275                 280                 285             

Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 
    290                 295                 300                 

Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
305                 310                 315                 320 

Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 
                325                 330                 335     

Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 
            340                 345                 350         

Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 
        355                 360                 365             

Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 
    370                 375                 380                 

Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
385                 390                 395                 400 

Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 
                405                 410                 415     

Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
            420                 425                 430         

Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 
        435                 440                 445             

Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 
    450                 455                 460                 

Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 
465                 470                 475                 480 

Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 
                485                 490                 495     

Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 
            500                 505                 510         

Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 
        515                 520                 525             

Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 
    530                 535                 540                 

Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 
545                 550                 555                 560 

Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 
                565                 570                 575     

Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 
            580                 585                 590         

Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 
        595                 600                 605             

Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 
    610                 615                 620                 

Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 
625                 630                 635                 640 

Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 
                645                 650                 655     

Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 
            660                 665                 670         

Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 
        675                 680                 685             

Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 
    690                 695                 700                 

Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 
705                 710                 715                 720 

Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 
                725                 730                 735     

Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 
            740                 745                 750         

Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 
        755                 760                 765             

Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 
    770                 775                 780                 

Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 
785                 790                 795                 800 

Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 
                805                 810                 815     

Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu 
            820                 825                 830         

Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 
        835                 840                 845             

Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 
    850                 855                 860                 

Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 
865                 870                 875                 880 

Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 
                885                 890                 895     

Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln 
            900                 905                 910         

Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 
        915                 920                 925             

Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly 
    930                 935                 940                 

Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 
945                 950                 955                 960 

Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 
                965                 970                 975     

Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 
            980                 985                 990         

Asp Ile Ala Gln Val Asn Leu Lys  Tyr Leu Leu Lys Leu  Lys Phe Asn 
        995                 1000                 1005             

Phe Lys  Thr Ser Leu Trp 
    1010                 


<210>  2
<211>  4001
<212>  DNA
<213>  homo sapiens

<400>  2
aggcatcagc aatctatcag ggaacggcgg tggccggtgc ggcgtgttcg gtggcggctc     60

tggccgctca ggcgcctgcg gctgggtgag cgcacgcgag gcggcgaggc ggcagcgtgt    120

ttctaggtcg tggcgtcggg cttccggagc tttggcggca gctaggggag gatggcggag    180

tcttcggata agctctatcg agtcgagtac gccaagagcg ggcgcgcctc ttgcaagaaa    240

tgcagcgaga gcatccccaa ggactcgctc cggatggcca tcatggtgca gtcgcccatg    300

tttgatggaa aagtcccaca ctggtaccac ttctcctgct tctggaaggt gggccactcc    360

atccggcacc ctgacgttga ggtggatggg ttctctgagc ttcggtggga tgaccagcag    420

aaagtcaaga agacagcgga agctggagga gtgacaggca aaggccagga tggaattggt    480

agcaaggcag agaagactct gggtgacttt gcagcagagt atgccaagtc caacagaagt    540

acgtgcaagg ggtgtatgga gaagatagaa aagggccagg tgcgcctgtc caagaagatg    600

gtggacccgg agaagccaca gctaggcatg attgaccgct ggtaccatcc aggctgcttt    660

gtcaagaaca gggaggagct gggtttccgg cccgagtaca gtgcgagtca gctcaagggc    720

ttcagcctcc ttgctacaga ggataaagaa gccctgaaga agcagctccc aggagtcaag    780

agtgaaggaa agagaaaagg cgatgaggtg gatggagtgg atgaagtggc gaagaagaaa    840

tctaaaaaag aaaaagacaa ggatagtaag cttgaaaaag ccctaaaggc tcagaacgac    900

ctgatctgga acatcaagga cgagctaaag aaagtgtgtt caactaatga cctgaaggag    960

ctactcatct tcaacaagca gcaagtgcct tctggggagt cggcgatctt ggaccgagta   1020

gctgatggca tggtgttcgg tgccctcctt ccctgcgagg aatgctcggg tcagctggtc   1080

ttcaagagcg atgcctatta ctgcactggg gacgtcactg cctggaccaa gtgtatggtc   1140

aagacacaga cacccaaccg gaaggagtgg gtaaccccaa aggaattccg agaaatctct   1200

tacctcaaga aattgaaggt taaaaaacag gaccgtatat tccccccaga aaccagcgcc   1260

tccgtggcgg ccacgcctcc gccctccaca gcctcggctc ctgctgctgt gaactcctct   1320

gcttcagcag ataagccatt atccaacatg aagatcctga ctctcgggaa gctgtcccgg   1380

aacaaggatg aagtgaaggc catgattgag aaactcgggg ggaagttgac ggggacggcc   1440

aacaaggctt ccctgtgcat cagcaccaaa aaggaggtgg aaaagatgaa taagaagatg   1500

gaggaagtaa aggaagccaa catccgagtt gtgtctgagg acttcctcca ggacgtctcc   1560

gcctccacca agagccttca ggagttgttc ttagcgcaca tcttgtcccc ttggggggca   1620

gaggtgaagg cagagcctgt tgaagttgtg gccccaagag ggaagtcagg ggctgcgctc   1680

tccaaaaaaa gcaagggcca ggtcaaggag gaaggtatca acaaatctga aaagagaatg   1740

aaattaactc ttaaaggagg agcagctgtg gatcctgatt ctggactgga acactctgcg   1800

catgtcctgg agaaaggtgg gaaggtcttc agtgccaccc ttggcctggt ggacatcgtt   1860

aaaggaacca actcctacta caagctgcag cttctggagg acgacaagga aaacaggtat   1920

tggatattca ggtcctgggg ccgtgtgggt acggtgatcg gtagcaacaa actggaacag   1980

atgccgtcca aggaggatgc cattgagcac ttcatgaaat tatatgaaga aaaaaccggg   2040

aacgcttggc actccaaaaa tttcacgaag tatcccaaaa agttctaccc cctggagatt   2100

gactatggcc aggatgaaga ggcagtgaag aagctgacag taaatcctgg caccaagtcc   2160

aagctcccca agccagttca ggacctcatc aagatgatct ttgatgtgga aagtatgaag   2220

aaagccatgg tggagtatga gatcgacctt cagaagatgc ccttggggaa gctgagcaaa   2280

aggcagatcc aggccgcata ctccatcctc agtgaggtcc agcaggcggt gtctcagggc   2340

agcagcgact ctcagatcct ggatctctca aatcgctttt acaccctgat cccccacgac   2400

tttgggatga agaagcctcc gctcctgaac aatgcagaca gtgtgcaggc caaggtggaa   2460

atgcttgaca acctgctgga catcgaggtg gcctacagtc tgctcagggg agggtctgat   2520

gatagcagca aggatcccat cgatgtcaac tatgagaagc tcaaaactga cattaaggtg   2580

gttgacagag attctgaaga agccgagatc atcaggaagt atgttaagaa cactcatgca   2640

accacacaca atgcgtatga cttggaagtc atcgatatct ttaagataga gcgtgaaggc   2700

gaatgccagc gttacaagcc ctttaagcag cttcataacc gaagattgct gtggcacggg   2760

tccaggacca ccaactttgc tgggatcctg tcccagggtc ttcggatagc cccgcctgaa   2820

gcgcccgtga caggctacat gtttggtaaa gggatctatt tcgctgacat ggtctccaag   2880

agtgccaact actgccatac gtctcaggga gacccaatag gcttaatcct gttgggagaa   2940

gttgcccttg gaaacatgta tgaactgaag cacgcttcac atatcagcaa gttacccaag   3000

ggcaagcaca gtgtcaaagg tttgggcaaa actacccctg atccttcagc taacattagt   3060

ctggatggtg tagacgttcc tcttgggacc gggatttcat ctggtgtgaa tgacacctct   3120

ctactatata acgagtacat tgtctatgat attgctcagg taaatctgaa gtatctgctg   3180

aaactgaaat tcaattttaa gacctccctg tggtaattgg gagaggtagc cgagtcacac   3240

ccggtggctc tggtatgaat tcacccgaag cgcttctgca ccaactcacc tggccgctaa   3300

gttgctgatg ggtagtacct gtactaaacc acctcagaaa ggattttaca gaaacgtgtt   3360

aaaggttttc tctaacttct caagtccctt gttttgtgtt gtgtctgtgg ggaggggttg   3420

ttttggggtt gtttttgttt tttcttgcca ggtagataaa actgacatag agaaaaggct   3480

ggagagagat tctgttgcat agactagtcc tatggaaaaa accaagcttc gttagaatgt   3540

ctgccttact ggtttcccca gggaaggaaa aatacacttc cacccttttt tctaagtgtt   3600

cgtctttagt tttgattttg gaaagatgtt aagcatttat ttttagttaa aaataaaaac   3660

taatttcata ctatttagat tttctttttt atcttgcact tattgtcccc tttttagttt   3720

tttttgtttg cctcttgtgg tgaggggtgt gggaagacca aaggaaggaa cgctaacaat   3780

ttctcatact tagaaacaaa aagagctttc cttctccagg aatactgaac atgggagctc   3840

ttgaaatatg tagtattaaa agttgcattt gaaattcttg actttcttat gggcactttt   3900

gtcttccaaa ttaaaactct accacaaata tacttaccca agggctaata gtaatactcg   3960

attaaaaatg cagatgcctt ctctaaaaaa aaaaaaaaaa a                       4001


<210>  3
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PARP1 (forward primer)

<400>  3
cccaaaggaa ttccgagaaa                                                 20


<210>  4
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  PARP1 (reward primer)

<400>  4
tcctttttgg tgctgatg                                                   18


<210>  5
<211>  934
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 
1               5                   10                  15      

Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr 
            20                  25                  30          

Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His Gly Glu 
        35                  40                  45              

Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr Gln Gly Val Ile 
    50                  55                  60                  

Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn Leu Gln Ser Val Val Leu 
65                  70                  75                  80  

Ser Lys Met Asn Phe Glu Ser Phe Val Lys Asp Leu Leu Leu Val Arg 
                85                  90                  95      

Gln Tyr Arg Val Glu Val Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 
            100                 105                 110         

Lys Glu Asn Asp Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 
        115                 120                 125             

Ser Gln Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 
    130                 135                 140                 

Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 

Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly Leu Cys 
                165                 170                 175     

Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu Ala Leu Leu Ile 
            180                 185                 190         

Gln Ile Gly Pro Lys Glu Cys Val Leu Pro Gly Gly Glu Thr Ala Gly 
        195                 200                 205             

Asp Met Gly Lys Leu Arg Gln Ile Ile Gln Arg Gly Gly Ile Leu Ile 
    210                 215                 220                 

Thr Glu Arg Lys Lys Ala Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 
225                 230                 235                 240 

Leu Asn Arg Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 
                245                 250                 255     

Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 
            260                 265                 270         

Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln 
        275                 280                 285             

Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu Asp Ile 
    290                 295                 300                 

Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser Val Glu Asp Thr 
305                 310                 315                 320 

Thr Gly Ser Gln Ser Leu Ala Ala Leu Leu Asn Lys Cys Lys Thr Pro 
                325                 330                 335     

Gln Gly Gln Arg Leu Val Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 
            340                 345                 350         

Lys Asn Arg Ile Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 
        355                 360                 365             

Asp Ala Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 
    370                 375                 380                 

Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 
385                 390                 395                 400 

Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro Asn 
                405                 410                 415     

Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln Lys Leu Leu 
            420                 425                 430         

Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu Arg Ser Asp Phe Ser 
        435                 440                 445             

Lys Phe Gln Glu Met Ile Glu Thr Thr Leu Asp Met Asp Gln Val Glu 
    450                 455                 460                 

Asn His Glu Phe Leu Val Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 
465                 470                 475                 480 

Leu Arg Glu Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 
                485                 490                 495     

Ile Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 
            500                 505                 510         

Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 
        515                 520                 525             

Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp Ile 
    530                 535                 540                 

Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr Ser Leu Asn 
545                 550                 555                 560 

Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala 
                565                 570                 575     

Ile Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met 
            580                 585                 590         

Gln Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 
        595                 600                 605             

Ala His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 
    610                 615                 620                 

Leu Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 
625                 630                 635                 640 

Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr 
                645                 650                 655     

Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met 
            660                 665                 670         

Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met 
        675                 680                 685             

Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile 
    690                 695                 700                 

Val Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys 
705                 710                 715                 720 

Gly Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 
                725                 730                 735     

Arg Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 
            740                 745                 750         

Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 
        755                 760                 765             

Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe 
    770                 775                 780                 

His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu 
785                 790                 795                 800 

His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln 
                805                 810                 815     

Val Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu 
            820                 825                 830         

Leu Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala 
        835                 840                 845             

Leu Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 
    850                 855                 860                 

Ile Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 
865                 870                 875                 880 

Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 
                885                 890                 895     

Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys 
            900                 905                 910         

Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser 
        915                 920                 925             

Arg Ile Lys Val Thr Thr 
    930                 


<210>  6
<211>  323
<212>  PRT
<213>  homo sapiens

<400>  6

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      

Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          

Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              

Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  

Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  

Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      

Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         

Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             

Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 

Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 

Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     

Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         

Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             

Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 

Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 

Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     

Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         

Leu Cys Pro Gly Leu Gly Pro Gln Lys Val Arg Ala Leu Gly Lys Asn 
        275                 280                 285             

Pro Arg Ser Trp Gly Lys Glu Arg Ala Pro Asn Lys His Asn Leu Arg 
    290                 295                 300                 

Pro Gln Ser Phe Lys Val Lys Lys Glu Pro Lys Thr Arg His Ser Gly 
305                 310                 315                 320 

Phe Arg Leu 
            


<210>  7
<211>  297
<212>  PRT
<213>  homo sapeins

<400>  7

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      

Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          

Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              

Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  

Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  

Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      

Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         

Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             

Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 

Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 

Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     

Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         

Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             

Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 

Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 

Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     

Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         

Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 
        275                 280                 285             

Leu His Glu Pro Phe Leu Lys Val Pro 
    290                 295         


<210>  8
<211>  3145
<212>  DNA
<213>  homo sapiens

<400>  8
ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag     60

gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg    120

gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg    180

accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt    240

tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg    300

ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt    360

atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt    420

atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta    480

acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc    540

agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat    600

tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg    660

aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc    720

aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt    780

atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat    840

tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag    900

aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc    960

agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg   1020

aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag   1080

gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg   1140

agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag   1200

aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag   1260

cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta   1320

tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga   1380

ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt   1440

tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc   1500

tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa   1560

gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac   1620

agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa   1680

actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt   1740

ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg   1800

ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg   1860

tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc   1920

catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca   1980

ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg   2040

aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat   2100

atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg   2160

agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc   2220

aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt   2280

ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg   2340

atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt   2400

gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta   2460

ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga   2520

agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta   2580

agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg   2640

gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag   2700

agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg   2760

aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa   2820

agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc   2880

cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt   2940

atattaaccc tttttccata gtgttaactg tcagtgccca tgggctatca acttaataag   3000

atatttagta atattttact ttgaggacat tttcaaagat ttttattttg aaaaatgaga   3060

gctgtaactg aggactgttt gcaattgaca taggcaataa taagtgatgt gctgaatttt   3120

ataaataaaa tcatgtagtt tgtgg                                         3145


<210>  9
<211>  1291
<212>  DNA
<213>  homo sapiens

<400>  9
gagccgaagg tggaggtcaa aggggcgtgg cgttacagag cctctagcgc tgggtgttgg     60

ggacctgacg ctatggagct ctcggagttt tgtgggggac ggctgtgagt ggggggttcc    120

tgctgcggga tgagaacgta gacgccagtg gctcactcgc tcctggcacc ttccctttca    180

ggctccagat ggaccctggg aaggacaaag agggggtgcc ccagccctca gggccgccag    240

caaggaagaa atttgtgata cccctcgacg aggatgaggt ccctcctgga gtggccaagc    300

ccttattccg atctacacag agccttccca ctgtggacac ctcggcccag gcggcccctc    360

agacctacgc cgaatatgcc atctcacagc ctctggaagg ggctggggcc acgtgcccca    420

cagggtcaga gcccctggca ggagagacgc ccaaccaggc cctgaaaccc ggggcaaaat    480

ccaacagcat cattgtgagc cctcggcaga ggggcaatcc cgtactgaag ttcgtgcgca    540

atgtgccctg ggaatttggc gacgtaattc ccgactatgt gctgggccag agcacctgtg    600

ccctgttcct cagcctccgc taccacaacc tgcacccaga ctacatccat gggcggctgc    660

agagcctggg gaagaacttc gccttgcggg tcctgcttgt ccaggtggat gtgaaagatc    720

cccagcaggc cctcaaggag ctggctaaga tgtgtatcct ggccgactgc acattgatcc    780

tcgcctggag ccccgaggaa gctgggcggt acctggagac ctacaaggcc tatgagcaga    840

aaccagcgga cctcctgatg gagaagctag agcaggactt cgtctcccgg gtgactgaat    900

gtctgaccac cgtgaagtca gtcaacaaaa cggacagtca gaccctcctg accacatttg    960

gatctctgga acagctcatc gccgcatcaa gagaagatct ggccttatgc ccaggcctgg   1020

gccctcagaa agtaagagct ctgggaaaga acccaaggag ttgggggaag gagagagccc   1080

caaataaaca caacctgaga ccccaaagtt ttaaggtgaa aaaagaacca aagaccagac   1140

acagtggctt ccgcctgtaa tcccaacatt ttgggaggcc aaggcgggag gactgcttga   1200

ggccagaagt tggagaccag cctgggcaag tggacacctc atttttacta aaaataaaaa   1260

aaactagctg ggcaaaaaaa aaaaaaaaaa a                                  1291


<210>  10
<211>  3400
<212>  DNA
<213>  homo sapiens

<400>  10
ccggaagtgc tgcgagccct gggccacgct ggccgtgctg gcagtgggcc gcctcgatcc     60

ctctgcagtc tttcccttga ggctccaaga ccagcaggtg aggcctcgcg gcgctgaaac    120

cgtgaggccc ggaccacagg ctccagatgg accctgggaa ggacaaagag ggggtgcccc    180

agccctcagg gccgccagca aggaagaaat ttgtgatacc cctcgacgag gatgaggtcc    240

ctcctggagt ggccaagccc ttattccgat ctacacagag ccttcccact gtggacacct    300

cggcccaggc ggcccctcag acctacgccg aatatgccat ctcacagcct ctggaagggg    360

ctggggccac gtgccccaca gggtcagagc ccctggcagg agagacgccc aaccaggccc    420

tgaaacccgg ggcaaaatcc aacagcatca ttgtgagccc tcggcagagg ggcaatcccg    480

tactgaagtt cgtgcgcaat gtgccctggg aatttggcga cgtaattccc gactatgtgc    540

tgggccagag cacctgtgcc ctgttcctca gcctccgcta ccacaacctg cacccagact    600

acatccatgg gcggctgcag agcctgggga agaacttcgc cttgcgggtc ctgcttgtcc    660

aggtggatgt gaaagatccc cagcaggccc tcaaggagct ggctaagatg tgtatcctgg    720

ccgactgcac attgatcctc gcctggagcc ccgaggaagc tgggcggtac ctggagacct    780

acaaggccta tgagcagaaa ccagcggacc tcctgatgga gaagctagag caggacttcg    840

tctcccgggt gactgaatgt ctgaccaccg tgaagtcagt caacaaaacg gacagtcaga    900

ccctcctgac cacatttgga tctctggaac agctcatcgc cgcatcaaga gaagatctgg    960

ccttatgccc aggcctgggc cctcagaaag cccggaggct gtttgatgtc ctgcacgagc   1020

ccttcttgaa agtaccctga tgaccccagc tgccaaggaa acccccagtg taataataaa   1080

tcgtcctccc aggccaggct cctgctggct gcgctggtgc agtctctggg gagggattct   1140

gggggtgtca ccttctggtg gcccaggtgg gcaccttcag ctttctttag ttcctcagtt   1200

tcccgggggc agactacaca ggctgctgct gctgctgctt ccgcttcttg tcccggcctg   1260

tgggagcctc ctccccagac tctgaattca gtggcggccc tggcatctcc tcttggggca   1320

ctgtctctgg catccggctt tcctgactct gcttcttcct cttcttggtg gatcccggag   1380

ttgccctggc ttcaggctgt ccctcccctg gcagttcagg ctctagtggc tgaattggct   1440

cagtcactgt gtgacctctc tctttcttct tcttcttctt cttggtggat gtgggagctg   1500

cctgaggctc aaggtcatcc ggcagctcag gccccaccac ctctgtctct ggctccactg   1560

tggcatcttg ctgtttttct ttcttcgtct tctttttggg agctgccaga gctgcctggg   1620

cctgaggctt cgctccttct ggctgttgag gcgccatggt cccccctggg gactccagag   1680

gcttcatctc cggctccact ggctccatcg cctccgtccc tggctccatc attgccatct   1740

gtcccttttc ttttttcctc ttcttcgtag ggggcagagg gatggcttcc tccagtggct   1800

ccaccttcac ctgtggctga gactcaactg tcaccccctc ctctggctcc atcccttccg   1860

tccccttttg cctctttctc tttttggtcg gggacaggac tgtgtcttct agaggctcag   1920

tgttaatctg ttcctgcttc actgtcttgt cttctggctc gaaggtttct ttccctttgg   1980

gcttcttcct cttcttggtg gtggacggga acagcactcc cagaggctcc agtgtctcca   2040

ctgtgggctc tgtccccaca ggccctgctg cctctggttc tttcagctgc tgattttttt   2100

tcttcttctt cttccgcaca tccatttctg gcgaccccaa agccatgtcc acctccaggg   2160

ccccgtgccc attcactgcc tcctgagtga ctggggcctc tgtcacctgc atctcctttt   2220

tcttcttccc tgaggtgagc aggttggggg ccaaggctga cctaggccct gtgactggtg   2280

ggttgccccc aaaggcacag aaccgaggcc tcaggccagg agggatctgt ggtgggggac   2340

ttgctgggat gggctgcaga gggctccctg acagggattg ctggggaccc tcaaggatcc   2400

ttagggtgcc ctggggggct gaggcacagg tgagtccacc tcctgcctcc gttgaggggg   2460

ccagcagggt cgcttctcca gcttggggac agctgctgag gactcgatag cggtgccgct   2520

tgcctgccaa tttgcccttg acgatctggg agccagagag aggcacatgc cgcccattga   2580

agctacagag agaaacaggg agggcagagg cttaagtgga acaggagagg gaaggttttt   2640

tgattttttt tttgtttttt tttgagagag tcttgctctg ttgcctaggc tggagtgcag   2700

tggcatgatc tcggctcact gcaatgtcca cctcctgggt tcaagcgatt ctcctgcctc   2760

agcctctcaa gtagctggga ttacaggcac ctgccaccac gcccagccaa tttttgtatt   2820

tttagtagag acaatttcac tatgttggcc aggctggtct tgaactcctg acctcaagtg   2880

atctgctcgc ctcggcctcc caaaggatgg gattacaggc accagccact gcgcctggct   2940

ggcctctggt ttttaataaa acatgactag agtgactcca tcttaaagtg agtagctagg   3000

cacttacaag gttcatgctt atggcctgaa aataaccaca tcccaggctg accaccaatt   3060

ataattacag aatatttatg gccatacaga acatgttcca ccaagcctgc agaatgtcca   3120

aatgtcctaa gaatgcagcc cccattactt aaatataaca taaatgagca agcttaggtt   3180

gcaggattaa tggtcgtgga taacaccaat agcccctacc tttagtgagc ttatctgcac   3240

actccaagtt taactatagt tccttatagt ttcttataag tagaaatact aacaaagggc   3300

tgtgggtttc tccccctgct ttctgaggac actctactct gtaaaggagt agtttccaat   3360

aaacttgttt ctttcactgt gcaaaaaaaa aaaaaaaaaa                         3400


<210>  11
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  ERCC1 (Forward primer)

<400>  11
gggaatttgg cgacgtaatt c                                               21


<210>  12
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  ERCC1 (Reward primer)

<400>  12
gcggaggctg aggaacag                                                   18


<210>  13
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  ERCC1 (Labeled Probe)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  6FAM 5' labeling

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  TAMRA 3' labeling

<400>  13
cacaggtgct ctggcccagc acata                                           25


