                         SEQUENCE LISTING

<110>  Koninklijke Philips Electronics N.V.
 
<120>  NOVEL TUMOR MARKERS

<130>  PH013962-WO1

<150>  EP09169423.2
<151>  2009-09-03

<150>  EP09169426.5
<151>  2009-09-03

<160>  884   

<170>  PatentIn version 3.5

<210>  1
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  1
atggccctct tcggggccct cttcctagcg ctgctggcag gcgcacatgc agagttccca       60

ggctgcaaga tccgcgtcac ctccaaggcg ctggagctgg tgaagcagga ggggctgcgc      120

tttctggagc aagagctgga gactatcacc attccggacc tgcggggcaa agaaggccac      180

ttctactaca acatctctga ggtgaaggtc acagagctgc aactgacatc ttccgagctc      240

gatttccagc cacagcagga gctgatgctt caaatcacca atgcctcctt ggggctgcgc      300

ttccggagac agctgctcta ctggttcttc tatgatgggg gctacatcaa cgcctcagct      360

gagggtgtgt ccatccgcac tggtctggag ctctcccggg atcccgctgg acggatgaaa      420

gtgtccaatg tctcctgcca ggcctctgtc tccagaatgc acgcggcctt cgggggaacc      480

ttcaagaagg tgtatgattt tctctccacg ttcatcacct cagggatgcg cttcctcctc      540

aaccagcaga tctgccctgt cctctaccac gcagggacgg tcctgctcaa ctccctcctg      600

gacaccgtgc ctgtgcgcag ttctgtggac gagcttgttg gcattgacta ttccctcatg      660

aaggatcctg tggcttccac cagcaacctg gacatggact tccggggggc cttcttcccc      720

ctgactgaga ggaactggag cctccccaac cgggcagtgg agccccagct gcaggaggaa      780

gagcggatgg tgtatgtggc cttctctgag ttcttcttcg actctgccat ggagagctac      840

ttccgggcgg gggccctgca gctgttgctg gtgggggaca aggtgcccca cgacctggac      900

atgctgctga gggccaccta ctttgggagc attgtcctgc tgagcccagc agtgattgac      960

tccccattga agctggagct gcgggtcctg gccccaccgc gctgcaccat caagccctct     1020

ggcaccacca tctctgtcac tgctagcgtc accattgccc tggtcccacc agaccagcct     1080

gaggtccagc tgtccagcat gactatggac gcccgtctca gcgccaagat ggctctccgg     1140

gggaaggccc tgcgcacgca gctggacctg cgcaggttcc gaatctattc caaccattct     1200

gcactggagt cgctggctct gatcccatta caggcccctc tgaagaccat gctgcagatt     1260

ggggtgatgc ccatgctcaa tgagcggacc tggcgtgggg tgcagatccc actacctgag     1320

ggcatcaact ttgtgcatga ggtggtgacg aaccatgcgg gattcctcac catcggggct     1380

gatctccact ttgccaaagg gctgcgagag gtgattgaga agaaccggcc tgctgatgtc     1440

agggcgtcca ctgcccccac accgtccaca gcagctgtct ga                        1482


<210>  2
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Phe Gly Ala Leu Phe Leu Ala Leu Leu Ala Gly Ala His 
1               5                   10                  15      


Ala Glu Phe Pro Gly Cys Lys Ile Arg Val Thr Ser Lys Ala Leu Glu 
            20                  25                  30          


Leu Val Lys Gln Glu Gly Leu Arg Phe Leu Glu Gln Glu Leu Glu Thr 
        35                  40                  45              


Ile Thr Ile Pro Asp Leu Arg Gly Lys Glu Gly His Phe Tyr Tyr Asn 
    50                  55                  60                  


Ile Ser Glu Val Lys Val Thr Glu Leu Gln Leu Thr Ser Ser Glu Leu 
65                  70                  75                  80  


Asp Phe Gln Pro Gln Gln Glu Leu Met Leu Gln Ile Thr Asn Ala Ser 
                85                  90                  95      


Leu Gly Leu Arg Phe Arg Arg Gln Leu Leu Tyr Trp Phe Phe Tyr Asp 
            100                 105                 110         


Gly Gly Tyr Ile Asn Ala Ser Ala Glu Gly Val Ser Ile Arg Thr Gly 
        115                 120                 125             


Leu Glu Leu Ser Arg Asp Pro Ala Gly Arg Met Lys Val Ser Asn Val 
    130                 135                 140                 


Ser Cys Gln Ala Ser Val Ser Arg Met His Ala Ala Phe Gly Gly Thr 
145                 150                 155                 160 


Phe Lys Lys Val Tyr Asp Phe Leu Ser Thr Phe Ile Thr Ser Gly Met 
                165                 170                 175     


Arg Phe Leu Leu Asn Gln Gln Ile Cys Pro Val Leu Tyr His Ala Gly 
            180                 185                 190         


Thr Val Leu Leu Asn Ser Leu Leu Asp Thr Val Pro Val Arg Ser Ser 
        195                 200                 205             


Val Asp Glu Leu Val Gly Ile Asp Tyr Ser Leu Met Lys Asp Pro Val 
    210                 215                 220                 


Ala Ser Thr Ser Asn Leu Asp Met Asp Phe Arg Gly Ala Phe Phe Pro 
225                 230                 235                 240 


Leu Thr Glu Arg Asn Trp Ser Leu Pro Asn Arg Ala Val Glu Pro Gln 
                245                 250                 255     


Leu Gln Glu Glu Glu Arg Met Val Tyr Val Ala Phe Ser Glu Phe Phe 
            260                 265                 270         


Phe Asp Ser Ala Met Glu Ser Tyr Phe Arg Ala Gly Ala Leu Gln Leu 
        275                 280                 285             


Leu Leu Val Gly Asp Lys Val Pro His Asp Leu Asp Met Leu Leu Arg 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ser Ile Val Leu Leu Ser Pro Ala Val Ile Asp 
305                 310                 315                 320 


Ser Pro Leu Lys Leu Glu Leu Arg Val Leu Ala Pro Pro Arg Cys Thr 
                325                 330                 335     


Ile Lys Pro Ser Gly Thr Thr Ile Ser Val Thr Ala Ser Val Thr Ile 
            340                 345                 350         


Ala Leu Val Pro Pro Asp Gln Pro Glu Val Gln Leu Ser Ser Met Thr 
        355                 360                 365             


Met Asp Ala Arg Leu Ser Ala Lys Met Ala Leu Arg Gly Lys Ala Leu 
    370                 375                 380                 


Arg Thr Gln Leu Asp Leu Arg Arg Phe Arg Ile Tyr Ser Asn His Ser 
385                 390                 395                 400 


Ala Leu Glu Ser Leu Ala Leu Ile Pro Leu Gln Ala Pro Leu Lys Thr 
                405                 410                 415     


Met Leu Gln Ile Gly Val Met Pro Met Leu Asn Glu Arg Thr Trp Arg 
            420                 425                 430         


Gly Val Gln Ile Pro Leu Pro Glu Gly Ile Asn Phe Val His Glu Val 
        435                 440                 445             


Val Thr Asn His Ala Gly Phe Leu Thr Ile Gly Ala Asp Leu His Phe 
    450                 455                 460                 


Ala Lys Gly Leu Arg Glu Val Ile Glu Lys Asn Arg Pro Ala Asp Val 
465                 470                 475                 480 


Arg Ala Ser Thr Ala Pro Thr Pro Ser Thr Ala Ala Val 
                485                 490             


<210>  3
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  3
atggagcgcg cgtcctgctt gttgctgctg ctgctgccgc tggtgcacgt ctctgcgacc       60

acgccagaac cttgtgagct ggacgatgaa gatttccgct gcgtctgcaa cttctccgaa      120

cctcagcccg actggtccga agccttccag tgtgtgtctg cagtagaggt ggagatccat      180

gccggcggtc tcaacctaga gccgtttcta aagcgcgtcg atgcggacgc cgacccgcgg      240

cagtatgctg acacggtcaa ggctctccgc gtgcggcggc tcacagtggg agccgcacag      300

gttcctgctc agctactggt aggcgccctg cgtgtgctag cgtactcccg cctcaaggaa      360

ctgacgctcg aggacctaaa gataaccggc accatgcctc cgctgcctct ggaagccaca      420

ggacttgcac tttccagctt gcgcctacgc aacgtgtcgt gggcgacagg gcgttcttgg      480

ctcgccgagc tgcagcagtg gctcaagcca ggcctcaagg tactgagcat tgcccaagca      540

cactcgcctg ccttttcctg cgaacaggtt cgcgccttcc cggcccttac cagcctagac      600

ctgtctgaca atcctggact gggcgaacgc ggactgatgg cggctctctg tccccacaag      660

ttcccggcca tccagaatct agcgctgcgc aacacaggaa tggagacgcc cacaggcgtg      720

tgcgccgcac tggcggcggc aggtgtgcag ccccacagcc tagacctcag ccacaactcg      780

ctgcgcgcca ccgtaaaccc tagcgctccg agatgcatgt ggtccagcgc cctgaactcc      840

ctcaatctgt cgttcgctgg gctggaacag gtgcctaaag gactgccagc caagctcaga      900

gtgctcgatc tcagctgcaa cagactgaac agggcgccgc agcctgacga gctgcccgag      960

gtggataacc tgacactgga cgggaatccc ttcctggtcc ctggaactgc cctcccccac     1020

gagggctcaa tgaactccgg cgtggtccca gcctgtgcac gttcgaccct gtcggtgggg     1080

gtgtcgggaa ccctggtgct gctccaaggg gcccggggct ttgcctaa                  1128


<210>  4
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  5
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  5
atggaggcaa tggcggccag cacttccctg cctgaccctg gagactttga ccggaacgtg       60

ccccggatct gtggggtgtg tggagaccga gccactggct ttcacttcaa tgctatgacc      120

tgtgaaggct gcaaaggctt cttcaggcga agcatgaagc ggaaggcact attcacctgc      180

cccttcaacg gggactgccg catcaccaag gacaaccgac gccactgcca ggcctgccgg      240

ctcaaacgct gtgtggacat cggcatgatg aaggagttca ttctgacaga tgaggaagtg      300

cagaggaagc gggagatgat cctgaagcgg aaggaggagg aggccttgaa ggacagtctg      360

cggcccaagc tgtctgagga gcagcagcgc atcattgcca tactgctgga cgcccaccat      420

aagacctacg accccaccta ctccgacttc tgccagttcc ggcctccagt tcgtgtgaat      480

gatggtggag ggagccatcc ttccaggccc aactccagac acactcccag cttctctggg      540

gactcctcct cctcctgctc agatcactgt atcacctctt cagacatgat ggactcgtcc      600

agcttctcca atctggatct gagtgaagaa gattcagatg acccttctgt gaccctagag      660

ctgtcccagc tctccatgct gccccacctg gctgacctgg tcagttacag catccaaaag      720

gtcattggct ttgctaagat gataccagga ttcagagacc tcacctctga ggaccagatc      780

gtactgctga agtcaagtgc cattgaggtc atcatgttgc gctccaatga gtccttcacc      840

atggacgaca tgtcctggac ctgtggcaac caagactaca agtaccgcgt cagtgacgtg      900

accaaagccg gacacagcct ggagctgatt gagcccctca tcaagttcca ggtgggactg      960

aagaagctga acttgcatga ggaggagcat gtcctgctca tggccatctg catcgtctcc     1020

ccagatcgtc ctggggtgca ggacgccgcg ctgattgagg ccatccagga ccgcctgtcc     1080

aacacactgc agacgtacat ccgctgccgc cacccgcccc cgggcagcca cctgctctat     1140

gccaagatga tccagaagct agccgacctg cgcagcctca atgaggagca ctccaagcag     1200

taccgctgcc tctccttcca gcctgagtgc agcatgaagc taacgcccct tgtgctcgaa     1260

gtgtttggca atgagatctc ctga                                            1284


<210>  6
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  


Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  


Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      


Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         


Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 


Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 


Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     


Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         


Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             


Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 


Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 


Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     


Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         


Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             


Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 


His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 


Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     


Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         


Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             


Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 


Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 


Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     


Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         


<210>  7
<211>  6801
<212>  DNA
<213>  Homo sapiens

<400>  7
atgatgccgg gcgagaccca ttcggcggcg cccgggacgg cggcggacct gtcgcgatgt       60

cagggctgcg cctctctgca gcagaatttg aatgaatatg ttgaagcatt aattaccttg      120

aaacaaaaaa ttatcaatac agataatttg ttaacagaat atcagaagaa atgtgatgag      180

ctgcagtttg caagaagaga gaatagtaat ctgcatcacc aagtggaaga gatgcttcaa      240

aaaatttctc ctctacagaa atgtcaggaa gaactgggat ctttaaaagc agagctagaa      300

gagaaaaaga gttctttaaa gttgtatcag gatactcatc aggaatatgc tcgtgtaaag      360

gaagaatgct tgaagagtga tgctcagaag aagaaactag aagctaaggt gaagaagctg      420

caagaggctg ctgtcaagca aactcaggac ttcaagcaac tgagaaatga aaagaaaata      480

cttgaaaagg aatttaagaa gacacaggaa aggcttgacg aattttctaa acagaaaaat      540

gaaaaggagt tgagacatat tggaacacaa atttcaagtg attcatatgg aagcatagat      600

aaaagaaaag tgaaactgct tctgaaggaa ctctggctct gtgtaaacac aacacacaga      660

ctacctggtg aaggcagcag gtgtgtccca gaaaaacctg ccaaagcaat caccagctcc      720

agagtgcctg gggaagatgg tacgctacct ccaacacagg gcagccctct caggacctca      780

aatgtgcaga catgcctcac aaaactgtcc atggagataa aggaggactt tttatgtcaa      840

aatgtggaaa aacagagctc cagtggaaca aattgtagtt ctgaccatgt ttttaatgag      900

aatggaaatc ttgaggtttt agtacaaagt catcgtgacg gtggtagtac tgaatttgtt      960

gatcatgatc atttttttga tgaagatctt caagctgcaa ttgacttctt caaacttccc     1020

cctcctcttc tgtcaccagt gccctcgccc cctccgatgt catcacctca cccgggttcc     1080

ttaccgtctt catttgcacc tgaaacctac tttggagaat acacagattc cagcgataat     1140

gactcagtcc agcttagaaa ttctgctgag tgtgtttcag aagatgatac aactgaatca     1200

cagaattatt ttggctcatt gagaaaaaat aaaggaagtg gcacatggga ggaaaagccc     1260

aaatcacatg aagctatcca agctctgaat acatgggaag taaataaagt gacaacttct     1320

ggactcgaga ctttcacagc aacactgaga gaatcttctg ccacacactc cttagttggt     1380

gaaaaacact ggaccacagc atctcgatcc atgagtgata gaaaaagaga cattttacat     1440

gagacaaaaa cacaaatgga ggttagggag atggataagt cagtacaaac tgagaagacc     1500

attcataaac tcactcgagg tctatgcatt gagagattgt ctgccagccc tgcacaagag     1560

aaggaagctg cccctgggaa gtctgagttg tgttcttctc cccttggcaa aaggccatta     1620

aatgaactca tggaatctga aggaaaaacc gtattgtcta aaatgatggg atcgcccaaa     1680

tcagagttta ctaagtggac acgaattaat gaaatcactt ctgaaccaga ccgtatcaca     1740

gtttctggcc attttcacag actatctaga gaattggaaa aggaaaaaga agatactcaa     1800

gggttcactt taggagaatc acctgaatca gaagatgatg actcaggtga tggaatggat     1860

gtagcagggc ttgacattga aaccagtttt tcttcctctt ctaccttggt agcattgtct     1920

gttggcagta atccccagtc ttcttctggg ttagactgtg gtaatgatac agatattact     1980

actaaagtat tctctactga accgcatcat tcagaacata aattgcaaac taaaacttta     2040

aacacattac atctgcagtc tgagccaccg gagtgttcta taggaggaaa caacttggag     2100

aatagcttgt gtgccttgag ccctgaattg ggagcatcta attttaatga tcagaagagc     2160

agtgggatag aatatacaaa agtagtaaaa ggcttgacca aaatacattc acttcctcgg     2220

tcagtattta tgaaagctac aaaagatggg caatgtgaaa gtcaagatcc aagaattgag     2280

ctcacactaa ataagccaga tttcacatca ttaataggtt ctcaggctgc cttgatcaag     2340

agtggtttgg gttttgttaa aagtacttca tggcaccata gtgatttatt aaggaaaggt     2400

ggcgaagaaa gtctgagagc caaatcagaa catgaacaga agactagcca tcagttacaa     2460

aaggcaatgc cattcctaca aaatagagga ccaacaccca agcctgatct tcttagagaa     2520

aataacaatc ctgtagaatt caagaccact gcatcggtgt tgcctaatca agtatcagtt     2580

atcacaaaac agacaagacc tgaaaaggtt cagagtgcca aattggaaca cttgaggcca     2640

catagggttg agcctacctt agtaacagaa aatagtggca acaaaaccgg tatgtcaact     2700

gtagcaaaat gtgatgggga aagagatgat acaacacaaa acatcacgga ggtggctgct     2760

gtgaaaagca tttcaccaga agtttctgcc tctaggagaa aattagattt taattctcca     2820

ggtggttctt caccagtaga aaattctgat tgttccacaa atagcagatt atctttctct     2880

cctgaaaata tcctcatcca aaaccaagac attgtgagag aagctgcagt gcagggagat     2940

gggcagaagc aaaggcagcc tcaggccaca gatctggact ccagtgggac acatggcagt     3000

gagatgcttc cagccacaga agtgactgtg tcaggagggt tttctgttga agaaaccagc     3060

tgtggagaca cagggagatc tggtggtgag gccctggctg ttgcaaatga ttctaccagc     3120

acaccacaaa atgctaatgg actttggaaa ttgaaatcta caactcccgg tggtgctttg     3180

cctgagtgtt ttggcaccac agacactact ttttcttcag cattttgcag aaaacatgga     3240

gagacacagg atacctccca aagtagcctg cctggtacct tacattgtta cacaggcatt     3300

cgagaggggg gagacgacac tgaggtagag agtgaggcat ttagctgcag tgaggggagc     3360

gaacagcaag atgctcctga tgactcacag aaaaatttag gagacacaga tgctgctgta     3420

gccgaggtga gaccttcctt agaggtaggt tatttgacgt cagctctgca agattttaac     3480

ataagtactt tttctgagct ggatagactt tccacatcag aggttgtgat gtttcttgag     3540

agctgtcagt taggggatta tagttcaggg gactctgttt ctgaatgttc tagtaaagga     3600

accctaagta aagaaatgaa caaagaatta aaggcaagtg aaataggaga aaaatacaga     3660

aagcaaccct gtgaggaaga aacacttgga acctgtgaag agtggattga atcagaggaa     3720

gatgattatt cgttaaaaaa tacaagtcag ctcactcagt gttctttgga aactctgtct     3780

gaggttctga ccaagattag gcaagaactt caaacaaatt ctgaagattg caatggtaaa     3840

gatactggca gtttattgct cttaaatgta aataacaaca tgaccactga gaatttaaaa     3900

gagaaaagtc catttcggga aacgactggc tcctcatcac atgcttcaga accaacccca     3960

caagcagctg ccttggacac tgagggcagc tctcccatca gcggtatgcc tcagaatgaa     4020

aaccctcaga gcagaccaga ggcccgttca gatgcaggca ggcaaaccga tggtggggaa     4080

gaagacctgc cagaacctgt ggagccatca gccttgtgct ctgactctgt gatggagcca     4140

tccatagagc aaagttctaa ctgcgaggcc gaaacaacat ttcagtgtca gatagcaaca     4200

gtgacctcag aagttataaa cgtacttata aataaggatc agaatctagt cattgaaaag     4260

ggggacaact ggacaatcat cagtggtgta gctgtcttgc cacatgtgga ccaggtcaca     4320

ctgtgtgaca ttcctggaga catccctatt tctcaggatc aaggagagct ggaagctggt     4380

tgcatcccag tgacttctgc tgagaagtcc ccagaggcca gtcacactgg ccctgcattt     4440

caggaggctc catgtggcaa taatctttca tgtccccaag aggatgtttc aagcagtggt     4500

cagagcacca actttgataa gagtcgtttg cgaaatagac ccgttaagcc tagtatatgg     4560

attagttctc aaatctatga tcaaaacttc gagactcaga ttgttgcgtc tgatcacaca     4620

tattataact caaaactaga gccatctggc aaaaataaga atcgatcaaa gatttcaaac     4680

aaagatcagt caaacaaacc agtaaaaact tcagcgtcga gcagagttga aactcatcag     4740

agtgaagttg ctcagtcatt ttcaggggaa aaagctaata caaaaactca aagaagccaa     4800

actcagacca ttttagcaaa tgctgataca tccactccta cagattgttc tcctgacaca     4860

ctgagtaaaa tacggcaaga ggtggggcct cctttgccgc ctctgcttgc tcctctgata     4920

gctacacctc caaggacttc acagccactg tctccactga tatcgagttc tagtccttcc     4980

tcaccagcct ctcctgttgg ccaggtttct cccttccgtg aaaccccagt gcctcctgcc     5040

atgtctccat ggccagagga ccccagacgt gcctctcctc cagatccttc tccatctcca     5100

tctgcagctt cagccagtga gagggtagtg ccgtctcctc tgcagttctg tgcggccacg     5160

ccgaagcacg cacttcctgt gcctggccga ctcccaccct gtgcatctgg ccacgctgct     5220

gtgggagggc ctcaggagaa ttctgtgaaa atccttgaca ccatgtatcc agagttatct     5280

gccagggccc ggaccctcaa catcctcaaa gggaatattc aactcacacg aggtccgcct     5340

gctgactgta agaatttacc gggacctgcc agtgctatga taggattcaa aacgatcact     5400

tcagcagcaa ctgcttttgt caaaactggg agcagctctg gtggtgactg taaccaagac     5460

aagtcaagag atttggggac tcagcaggat tcaagcggga aaagaacact gtcaacgtct     5520

acactgagaa gtgctaaaag actgcgcctg gacactgggt ccccagaacc agaaaccagg     5580

ggagtcactg cagaaggaat ccacaaaaac ctcccaggga acctccctcc agctgaagtt     5640

gcaacaacaa atgaggaaag aagttgttct agtccagccg tcagtgcagt ttcacagttg     5700

cctttaagcc caaaagaaac tgtggagtcc catgataaag ccatagctaa tgccctgaag     5760

aaaattgcag agttttcttt tgatctgtta cctgtcattc gtagtcatgt gtatgtggga     5820

aatatctcca aaaagcccgt aatgagagat caagagaagg aagttgttta tgaatttagc     5880

acaacaaaaa agcatttagc agagtgcttg cttcactcta ttctctcaga actaaaaatt     5940

cagaagatat ctatggacca caattacatt cacgccctct gcagggtgta tgtgggtatt     6000

tgtcggcaac tcggagactt ggaaagagct cgtttgtttt gctacagcct acttaaagaa     6060

gattttccgg agtctgaaaa attaactttg tttattgcaa acatgtggca tgatatattt     6120

ctctctcaat cggtgattaa taaagcaatg cagttagttg ccaggcaacg tgctaaagga     6180

gaggttctga actgcttgag agcttttctt aattgggaaa agaatgcccc ggtagatgtt     6240

ggcttcatgg tttctaagct gcttttgacc atacagttat gtccaaaaac agaatttcaa     6300

cctagtgaaa aatttggtga agacctaagt gataacactt gggaatacat atttgccatt     6360

gatctgctct gctgccatca gaaatggatc tggacgcatg ataacatcat aagtaaggag     6420

ctgtggcctg tgatggataa atggataaaa tacagaaaag gacatgcaaa cattgcgtat     6480

actcctgata ttattatagc ctcaatactg aggctgattg gtcgtttagg ccaattgggt     6540

ttgaaagaag gatttccatc tgctgtgaaa aatattagtt cggttattgg tatgtttata     6600

cagcatgctc acgatgaaga tataccatgg ggtatacagt tagcagccgt gtatgctctt     6660

tgtgacttga gtcccagcaa tccagcagaa atttccaaga tcctggaagc ttggcggaga     6720

gaggcctcca aaagcgttcc gtctgcgatt gtcagctgcc tagaggaagt cagtgccctg     6780

agcacagagg agcttggctg a                                               6801


<210>  8
<211>  2266
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met Pro Gly Glu Thr His Ser Ala Ala Pro Gly Thr Ala Ala Asp 
1               5                   10                  15      


Leu Ser Arg Cys Gln Gly Cys Ala Ser Leu Gln Gln Asn Leu Asn Glu 
            20                  25                  30          


Tyr Val Glu Ala Leu Ile Thr Leu Lys Gln Lys Ile Ile Asn Thr Asp 
        35                  40                  45              


Asn Leu Leu Thr Glu Tyr Gln Lys Lys Cys Asp Glu Leu Gln Phe Ala 
    50                  55                  60                  


Arg Arg Glu Asn Ser Asn Leu His His Gln Val Glu Glu Met Leu Gln 
65                  70                  75                  80  


Lys Ile Ser Pro Leu Gln Lys Cys Gln Glu Glu Leu Gly Ser Leu Lys 
                85                  90                  95      


Ala Glu Leu Glu Glu Lys Lys Ser Ser Leu Lys Leu Tyr Gln Asp Thr 
            100                 105                 110         


His Gln Glu Tyr Ala Arg Val Lys Glu Glu Cys Leu Lys Ser Asp Ala 
        115                 120                 125             


Gln Lys Lys Lys Leu Glu Ala Lys Val Lys Lys Leu Gln Glu Ala Ala 
    130                 135                 140                 


Val Lys Gln Thr Gln Asp Phe Lys Gln Leu Arg Asn Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Lys Lys Thr Gln Glu Arg Leu Asp Glu Phe Ser 
                165                 170                 175     


Lys Gln Lys Asn Glu Lys Glu Leu Arg His Ile Gly Thr Gln Ile Ser 
            180                 185                 190         


Ser Asp Ser Tyr Gly Ser Ile Asp Lys Arg Lys Val Lys Leu Leu Leu 
        195                 200                 205             


Lys Glu Leu Trp Leu Cys Val Asn Thr Thr His Arg Leu Pro Gly Glu 
    210                 215                 220                 


Gly Ser Arg Cys Val Pro Glu Lys Pro Ala Lys Ala Ile Thr Ser Ser 
225                 230                 235                 240 


Arg Val Pro Gly Glu Asp Gly Thr Leu Pro Pro Thr Gln Gly Ser Pro 
                245                 250                 255     


Leu Arg Thr Ser Asn Val Gln Thr Cys Leu Thr Lys Leu Ser Met Glu 
            260                 265                 270         


Ile Lys Glu Asp Phe Leu Cys Gln Asn Val Glu Lys Gln Ser Ser Ser 
        275                 280                 285             


Gly Thr Asn Cys Ser Ser Asp His Val Phe Asn Glu Asn Gly Asn Leu 
    290                 295                 300                 


Glu Val Leu Val Gln Ser His Arg Asp Gly Gly Ser Thr Glu Phe Val 
305                 310                 315                 320 


Asp His Asp His Phe Phe Asp Glu Asp Leu Gln Ala Ala Ile Asp Phe 
                325                 330                 335     


Phe Lys Leu Pro Pro Pro Leu Leu Ser Pro Val Pro Ser Pro Pro Pro 
            340                 345                 350         


Met Ser Ser Pro His Pro Gly Ser Leu Pro Ser Ser Phe Ala Pro Glu 
        355                 360                 365             


Thr Tyr Phe Gly Glu Tyr Thr Asp Ser Ser Asp Asn Asp Ser Val Gln 
    370                 375                 380                 


Leu Arg Asn Ser Ala Glu Cys Val Ser Glu Asp Asp Thr Thr Glu Ser 
385                 390                 395                 400 


Gln Asn Tyr Phe Gly Ser Leu Arg Lys Asn Lys Gly Ser Gly Thr Trp 
                405                 410                 415     


Glu Glu Lys Pro Lys Ser His Glu Ala Ile Gln Ala Leu Asn Thr Trp 
            420                 425                 430         


Glu Val Asn Lys Val Thr Thr Ser Gly Leu Glu Thr Phe Thr Ala Thr 
        435                 440                 445             


Leu Arg Glu Ser Ser Ala Thr His Ser Leu Val Gly Glu Lys His Trp 
    450                 455                 460                 


Thr Thr Ala Ser Arg Ser Met Ser Asp Arg Lys Arg Asp Ile Leu His 
465                 470                 475                 480 


Glu Thr Lys Thr Gln Met Glu Val Arg Glu Met Asp Lys Ser Val Gln 
                485                 490                 495     


Thr Glu Lys Thr Ile His Lys Leu Thr Arg Gly Leu Cys Ile Glu Arg 
            500                 505                 510         


Leu Ser Ala Ser Pro Ala Gln Glu Lys Glu Ala Ala Pro Gly Lys Ser 
        515                 520                 525             


Glu Leu Cys Ser Ser Pro Leu Gly Lys Arg Pro Leu Asn Glu Leu Met 
    530                 535                 540                 


Glu Ser Glu Gly Lys Thr Val Leu Ser Lys Met Met Gly Ser Pro Lys 
545                 550                 555                 560 


Ser Glu Phe Thr Lys Trp Thr Arg Ile Asn Glu Ile Thr Ser Glu Pro 
                565                 570                 575     


Asp Arg Ile Thr Val Ser Gly His Phe His Arg Leu Ser Arg Glu Leu 
            580                 585                 590         


Glu Lys Glu Lys Glu Asp Thr Gln Gly Phe Thr Leu Gly Glu Ser Pro 
        595                 600                 605             


Glu Ser Glu Asp Asp Asp Ser Gly Asp Gly Met Asp Val Ala Gly Leu 
    610                 615                 620                 


Asp Ile Glu Thr Ser Phe Ser Ser Ser Ser Thr Leu Val Ala Leu Ser 
625                 630                 635                 640 


Val Gly Ser Asn Pro Gln Ser Ser Ser Gly Leu Asp Cys Gly Asn Asp 
                645                 650                 655     


Thr Asp Ile Thr Thr Lys Val Phe Ser Thr Glu Pro His His Ser Glu 
            660                 665                 670         


His Lys Leu Gln Thr Lys Thr Leu Asn Thr Leu His Leu Gln Ser Glu 
        675                 680                 685             


Pro Pro Glu Cys Ser Ile Gly Gly Asn Asn Leu Glu Asn Ser Leu Cys 
    690                 695                 700                 


Ala Leu Ser Pro Glu Leu Gly Ala Ser Asn Phe Asn Asp Gln Lys Ser 
705                 710                 715                 720 


Ser Gly Ile Glu Tyr Thr Lys Val Val Lys Gly Leu Thr Lys Ile His 
                725                 730                 735     


Ser Leu Pro Arg Ser Val Phe Met Lys Ala Thr Lys Asp Gly Gln Cys 
            740                 745                 750         


Glu Ser Gln Asp Pro Arg Ile Glu Leu Thr Leu Asn Lys Pro Asp Phe 
        755                 760                 765             


Thr Ser Leu Ile Gly Ser Gln Ala Ala Leu Ile Lys Ser Gly Leu Gly 
    770                 775                 780                 


Phe Val Lys Ser Thr Ser Trp His His Ser Asp Leu Leu Arg Lys Gly 
785                 790                 795                 800 


Gly Glu Glu Ser Leu Arg Ala Lys Ser Glu His Glu Gln Lys Thr Ser 
                805                 810                 815     


His Gln Leu Gln Lys Ala Met Pro Phe Leu Gln Asn Arg Gly Pro Thr 
            820                 825                 830         


Pro Lys Pro Asp Leu Leu Arg Glu Asn Asn Asn Pro Val Glu Phe Lys 
        835                 840                 845             


Thr Thr Ala Ser Val Leu Pro Asn Gln Val Ser Val Ile Thr Lys Gln 
    850                 855                 860                 


Thr Arg Pro Glu Lys Val Gln Ser Ala Lys Leu Glu His Leu Arg Pro 
865                 870                 875                 880 


His Arg Val Glu Pro Thr Leu Val Thr Glu Asn Ser Gly Asn Lys Thr 
                885                 890                 895     


Gly Met Ser Thr Val Ala Lys Cys Asp Gly Glu Arg Asp Asp Thr Thr 
            900                 905                 910         


Gln Asn Ile Thr Glu Val Ala Ala Val Lys Ser Ile Ser Pro Glu Val 
        915                 920                 925             


Ser Ala Ser Arg Arg Lys Leu Asp Phe Asn Ser Pro Gly Gly Ser Ser 
    930                 935                 940                 


Pro Val Glu Asn Ser Asp Cys Ser Thr Asn Ser Arg Leu Ser Phe Ser 
945                 950                 955                 960 


Pro Glu Asn Ile Leu Ile Gln Asn Gln Asp Ile Val Arg Glu Ala Ala 
                965                 970                 975     


Val Gln Gly Asp Gly Gln Lys Gln Arg Gln Pro Gln Ala Thr Asp Leu 
            980                 985                 990         


Asp Ser Ser Gly Thr His Gly Ser  Glu Met Leu Pro Ala  Thr Glu Val 
        995                 1000                 1005             


Thr Val  Ser Gly Gly Phe Ser  Val Glu Glu Thr Ser  Cys Gly Asp 
    1010                 1015                 1020             


Thr Gly  Arg Ser Gly Gly Glu  Ala Leu Ala Val Ala  Asn Asp Ser 
    1025                 1030                 1035             


Thr Ser  Thr Pro Gln Asn Ala  Asn Gly Leu Trp Lys  Leu Lys Ser 
    1040                 1045                 1050             


Thr Thr  Pro Gly Gly Ala Leu  Pro Glu Cys Phe Gly  Thr Thr Asp 
    1055                 1060                 1065             


Thr Thr  Phe Ser Ser Ala Phe  Cys Arg Lys His Gly  Glu Thr Gln 
    1070                 1075                 1080             


Asp Thr  Ser Gln Ser Ser Leu  Pro Gly Thr Leu His  Cys Tyr Thr 
    1085                 1090                 1095             


Gly Ile  Arg Glu Gly Gly Asp  Asp Thr Glu Val Glu  Ser Glu Ala 
    1100                 1105                 1110             


Phe Ser  Cys Ser Glu Gly Ser  Glu Gln Gln Asp Ala  Pro Asp Asp 
    1115                 1120                 1125             


Ser Gln  Lys Asn Leu Gly Asp  Thr Asp Ala Ala Val  Ala Glu Val 
    1130                 1135                 1140             


Arg Pro  Ser Leu Glu Val Gly  Tyr Leu Thr Ser Ala  Leu Gln Asp 
    1145                 1150                 1155             


Phe Asn  Ile Ser Thr Phe Ser  Glu Leu Asp Arg Leu  Ser Thr Ser 
    1160                 1165                 1170             


Glu Val  Val Met Phe Leu Glu  Ser Cys Gln Leu Gly  Asp Tyr Ser 
    1175                 1180                 1185             


Ser Gly  Asp Ser Val Ser Glu  Cys Ser Ser Lys Gly  Thr Leu Ser 
    1190                 1195                 1200             


Lys Glu  Met Asn Lys Glu Leu  Lys Ala Ser Glu Ile  Gly Glu Lys 
    1205                 1210                 1215             


Tyr Arg  Lys Gln Pro Cys Glu  Glu Glu Thr Leu Gly  Thr Cys Glu 
    1220                 1225                 1230             


Glu Trp  Ile Glu Ser Glu Glu  Asp Asp Tyr Ser Leu  Lys Asn Thr 
    1235                 1240                 1245             


Ser Gln  Leu Thr Gln Cys Ser  Leu Glu Thr Leu Ser  Glu Val Leu 
    1250                 1255                 1260             


Thr Lys  Ile Arg Gln Glu Leu  Gln Thr Asn Ser Glu  Asp Cys Asn 
    1265                 1270                 1275             


Gly Lys  Asp Thr Gly Ser Leu  Leu Leu Leu Asn Val  Asn Asn Asn 
    1280                 1285                 1290             


Met Thr  Thr Glu Asn Leu Lys  Glu Lys Ser Pro Phe  Arg Glu Thr 
    1295                 1300                 1305             


Thr Gly  Ser Ser Ser His Ala  Ser Glu Pro Thr Pro  Gln Ala Ala 
    1310                 1315                 1320             


Ala Leu  Asp Thr Glu Gly Ser  Ser Pro Ile Ser Gly  Met Pro Gln 
    1325                 1330                 1335             


Asn Glu  Asn Pro Gln Ser Arg  Pro Glu Ala Arg Ser  Asp Ala Gly 
    1340                 1345                 1350             


Arg Gln  Thr Asp Gly Gly Glu  Glu Asp Leu Pro Glu  Pro Val Glu 
    1355                 1360                 1365             


Pro Ser  Ala Leu Cys Ser Asp  Ser Val Met Glu Pro  Ser Ile Glu 
    1370                 1375                 1380             


Gln Ser  Ser Asn Cys Glu Ala  Glu Thr Thr Phe Gln  Cys Gln Ile 
    1385                 1390                 1395             


Ala Thr  Val Thr Ser Glu Val  Ile Asn Val Leu Ile  Asn Lys Asp 
    1400                 1405                 1410             


Gln Asn  Leu Val Ile Glu Lys  Gly Asp Asn Trp Thr  Ile Ile Ser 
    1415                 1420                 1425             


Gly Val  Ala Val Leu Pro His  Val Asp Gln Val Thr  Leu Cys Asp 
    1430                 1435                 1440             


Ile Pro  Gly Asp Ile Pro Ile  Ser Gln Asp Gln Gly  Glu Leu Glu 
    1445                 1450                 1455             


Ala Gly  Cys Ile Pro Val Thr  Ser Ala Glu Lys Ser  Pro Glu Ala 
    1460                 1465                 1470             


Ser His  Thr Gly Pro Ala Phe  Gln Glu Ala Pro Cys  Gly Asn Asn 
    1475                 1480                 1485             


Leu Ser  Cys Pro Gln Glu Asp  Val Ser Ser Ser Gly  Gln Ser Thr 
    1490                 1495                 1500             


Asn Phe  Asp Lys Ser Arg Leu  Arg Asn Arg Pro Val  Lys Pro Ser 
    1505                 1510                 1515             


Ile Trp  Ile Ser Ser Gln Ile  Tyr Asp Gln Asn Phe  Glu Thr Gln 
    1520                 1525                 1530             


Ile Val  Ala Ser Asp His Thr  Tyr Tyr Asn Ser Lys  Leu Glu Pro 
    1535                 1540                 1545             


Ser Gly  Lys Asn Lys Asn Arg  Ser Lys Ile Ser Asn  Lys Asp Gln 
    1550                 1555                 1560             


Ser Asn  Lys Pro Val Lys Thr  Ser Ala Ser Ser Arg  Val Glu Thr 
    1565                 1570                 1575             


His Gln  Ser Glu Val Ala Gln  Ser Phe Ser Gly Glu  Lys Ala Asn 
    1580                 1585                 1590             


Thr Lys  Thr Gln Arg Ser Gln  Thr Gln Thr Ile Leu  Ala Asn Ala 
    1595                 1600                 1605             


Asp Thr  Ser Thr Pro Thr Asp  Cys Ser Pro Asp Thr  Leu Ser Lys 
    1610                 1615                 1620             


Ile Arg  Gln Glu Val Gly Pro  Pro Leu Pro Pro Leu  Leu Ala Pro 
    1625                 1630                 1635             


Leu Ile  Ala Thr Pro Pro Arg  Thr Ser Gln Pro Leu  Ser Pro Leu 
    1640                 1645                 1650             


Ile Ser  Ser Ser Ser Pro Ser  Ser Pro Ala Ser Pro  Val Gly Gln 
    1655                 1660                 1665             


Val Ser  Pro Phe Arg Glu Thr  Pro Val Pro Pro Ala  Met Ser Pro 
    1670                 1675                 1680             


Trp Pro  Glu Asp Pro Arg Arg  Ala Ser Pro Pro Asp  Pro Ser Pro 
    1685                 1690                 1695             


Ser Pro  Ser Ala Ala Ser Ala  Ser Glu Arg Val Val  Pro Ser Pro 
    1700                 1705                 1710             


Leu Gln  Phe Cys Ala Ala Thr  Pro Lys His Ala Leu  Pro Val Pro 
    1715                 1720                 1725             


Gly Arg  Leu Pro Pro Cys Ala  Ser Gly His Ala Ala  Val Gly Gly 
    1730                 1735                 1740             


Pro Gln  Glu Asn Ser Val Lys  Ile Leu Asp Thr Met  Tyr Pro Glu 
    1745                 1750                 1755             


Leu Ser  Ala Arg Ala Arg Thr  Leu Asn Ile Leu Lys  Gly Asn Ile 
    1760                 1765                 1770             


Gln Leu  Thr Arg Gly Pro Pro  Ala Asp Cys Lys Asn  Leu Pro Gly 
    1775                 1780                 1785             


Pro Ala  Ser Ala Met Ile Gly  Phe Lys Thr Ile Thr  Ser Ala Ala 
    1790                 1795                 1800             


Thr Ala  Phe Val Lys Thr Gly  Ser Ser Ser Gly Gly  Asp Cys Asn 
    1805                 1810                 1815             


Gln Asp  Lys Ser Arg Asp Leu  Gly Thr Gln Gln Asp  Ser Ser Gly 
    1820                 1825                 1830             


Lys Arg  Thr Leu Ser Thr Ser  Thr Leu Arg Ser Ala  Lys Arg Leu 
    1835                 1840                 1845             


Arg Leu  Asp Thr Gly Ser Pro  Glu Pro Glu Thr Arg  Gly Val Thr 
    1850                 1855                 1860             


Ala Glu  Gly Ile His Lys Asn  Leu Pro Gly Asn Leu  Pro Pro Ala 
    1865                 1870                 1875             


Glu Val  Ala Thr Thr Asn Glu  Glu Arg Ser Cys Ser  Ser Pro Ala 
    1880                 1885                 1890             


Val Ser  Ala Val Ser Gln Leu  Pro Leu Ser Pro Lys  Glu Thr Val 
    1895                 1900                 1905             


Glu Ser  His Asp Lys Ala Ile  Ala Asn Ala Leu Lys  Lys Ile Ala 
    1910                 1915                 1920             


Glu Phe  Ser Phe Asp Leu Leu  Pro Val Ile Arg Ser  His Val Tyr 
    1925                 1930                 1935             


Val Gly  Asn Ile Ser Lys Lys  Pro Val Met Arg Asp  Gln Glu Lys 
    1940                 1945                 1950             


Glu Val  Val Tyr Glu Phe Ser  Thr Thr Lys Lys His  Leu Ala Glu 
    1955                 1960                 1965             


Cys Leu  Leu His Ser Ile Leu  Ser Glu Leu Lys Ile  Gln Lys Ile 
    1970                 1975                 1980             


Ser Met  Asp His Asn Tyr Ile  His Ala Leu Cys Arg  Val Tyr Val 
    1985                 1990                 1995             


Gly Ile  Cys Arg Gln Leu Gly  Asp Leu Glu Arg Ala  Arg Leu Phe 
    2000                 2005                 2010             


Cys Tyr  Ser Leu Leu Lys Glu  Asp Phe Pro Glu Ser  Glu Lys Leu 
    2015                 2020                 2025             


Thr Leu  Phe Ile Ala Asn Met  Trp His Asp Ile Phe  Leu Ser Gln 
    2030                 2035                 2040             


Ser Val  Ile Asn Lys Ala Met  Gln Leu Val Ala Arg  Gln Arg Ala 
    2045                 2050                 2055             


Lys Gly  Glu Val Leu Asn Cys  Leu Arg Ala Phe Leu  Asn Trp Glu 
    2060                 2065                 2070             


Lys Asn  Ala Pro Val Asp Val  Gly Phe Met Val Ser  Lys Leu Leu 
    2075                 2080                 2085             


Leu Thr  Ile Gln Leu Cys Pro  Lys Thr Glu Phe Gln  Pro Ser Glu 
    2090                 2095                 2100             


Lys Phe  Gly Glu Asp Leu Ser  Asp Asn Thr Trp Glu  Tyr Ile Phe 
    2105                 2110                 2115             


Ala Ile  Asp Leu Leu Cys Cys  His Gln Lys Trp Ile  Trp Thr His 
    2120                 2125                 2130             


Asp Asn  Ile Ile Ser Lys Glu  Leu Trp Pro Val Met  Asp Lys Trp 
    2135                 2140                 2145             


Ile Lys  Tyr Arg Lys Gly His  Ala Asn Ile Ala Tyr  Thr Pro Asp 
    2150                 2155                 2160             


Ile Ile  Ile Ala Ser Ile Leu  Arg Leu Ile Gly Arg  Leu Gly Gln 
    2165                 2170                 2175             


Leu Gly  Leu Lys Glu Gly Phe  Pro Ser Ala Val Lys  Asn Ile Ser 
    2180                 2185                 2190             


Ser Val  Ile Gly Met Phe Ile  Gln His Ala His Asp  Glu Asp Ile 
    2195                 2200                 2205             


Pro Trp  Gly Ile Gln Leu Ala  Ala Val Tyr Ala Leu  Cys Asp Leu 
    2210                 2215                 2220             


Ser Pro  Ser Asn Pro Ala Glu  Ile Ser Lys Ile Leu  Glu Ala Trp 
    2225                 2230                 2235             


Arg Arg  Glu Ala Ser Lys Ser  Val Pro Ser Ala Ile  Val Ser Cys 
    2240                 2245                 2250             


Leu Glu  Glu Val Ser Ala Leu  Ser Thr Glu Glu Leu  Gly 
    2255                 2260                 2265     


<210>  9
<211>  2244
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcggagg ccgtggagcg cactgacgag ctggtccggg agtacctgct cttccgcggg       60

ttcacgcaca cactgcggca gctggacgcc gagatcaagg cggacaagga gaaggggttc      120

cgggtggata agattgtgga ccagctgcag cagttaatgc aggtgtatga cttggctgcc      180

cttcgggatt attggagcta cttggagcgt cggctcttca gccgcttgga ggatatatac      240

agacccacaa tccacaagct gaaaaccagc ctgtttcgat tttatcttgt ctacacaatc      300

cagacaaaca gaaatgacaa ggctcaggag ttctttgcaa agcaggccac ggaactccag      360

aaccaggctg agtggaagga ttggtttgtc ctgcccttcc tgccatcccc ggacaccaac      420

cccacctttg ctacctactt ttctcgacag tgggctgaca ccttcattgt gtccctgcac      480

aacttcctga gcgtcctgtt tcagtgcatg ccagtccctg tgatcctgaa ctttgatgcg      540

gagtgtcaga ggactaacca ggttcaagaa gaaaatgaag ttctgcgtca gaagcttttt      600

gcattgcaag ctgaaatcca ccgactgaag aaagaggagc aacagccaga agaggaagag      660

gccttggtcc aacacaaatt gcctccttat gtctccaaca tggaccgcct gggggactcg      720

gaacttgcca tggtgtgcag ccaaaggaat gcctccctct cccagtcacc tcgtgtgggc      780

ttcctgtcct cgctgctgcc tcagagtaag aagagcccct caaggttgtc gcctgctcag      840

ggccctcctc aacctcagag ctcggccaag aaagagtcct tcggtggtca gggcaccaag      900

ggaaaggacc cgacgtccgg agccaaggat gggaagagcc tcctcagcgg gctggccact      960

ggggagtccg gttggtcaca gcaccggcag cggcgcctgc aggaccatgg caaggagagg     1020

aaggagcttt tctccacaac cacttcccag tgtgcagaga agaaaccaga agccagtggc     1080

ccagaggctg agccctgccc agagctccac acggagccag tggagccact gactcgggca     1140

tcctcggcag gccctgaggg tggaggagtc cgccccgagc agccctttat tgtgctggga     1200

caggaggagt acggggaaca ccactcatcc atcatgcact gcagagtgga ctgctctggg     1260

aggagagtcg ccagcttaga cgtagatggg gtcatcaaag tgtggtcctt caaccccatc     1320

atgcagacca aagcatcctc catttccaaa tcaccgctgc tgtctttgga atgggccacc     1380

aaacgggaca gactgctctt gctgggcagt ggtgtgggaa cagtgcgtct ctatgacacg     1440

gaagccaaga agaatctctg tgaaatcaat atcaacgaca acatgcccag aatcctgtct     1500

cttgcgtgca gccccaacgg ggcctctttc gtctgttcgg cagcagctcc gagcctcact     1560

tcccaggtgg acttctcagc accagacatc ggcagcaagg gcatgaacca ggttcctggc     1620

aggctgctgc tgtgggacac gaaaaccatg aagcagcagc tccagttctc cctggatcca     1680

gaacccattg ctatcaactg tacagccttc aatcacaacg ggaacctgct ggtcacaggg     1740

gcagctgatg gcgtcatccg gctgtttgac atgcagcagc atgagtgcgc gatgagctgg     1800

agggcccact acggggaggt ctactctgtg gagttcagct atgatgagaa caccgtgtac     1860

agcatcggcg aggacgggaa gttcatccag tggaacatcc acaagagtgg cctcaaggta     1920

tccgagtaca gcctcccctc agatgccacg ggcccctttg tgctgtctgg atacagcggc     1980

tacaagcagg ttcaagtccc caggggccga ctcttcgctt ttgactcgga gggaaattac     2040

atgctgacat gttctgccac aggcggcgtc atctacaagc tgggtggcga tgagaaggtt     2100

ctggagagct gcttgagcct aggtggccac cgagcccctg tggtcaccgt ggactggagc     2160

actgccatgg actgtgggac ctgcctcacc gcctccatgg atggcaagat caagctgacc     2220

accctcctgg cccataaagc ctga                                            2244


<210>  10
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Ala Val Glu Arg Thr Asp Glu Leu Val Arg Glu Tyr Leu 
1               5                   10                  15      


Leu Phe Arg Gly Phe Thr His Thr Leu Arg Gln Leu Asp Ala Glu Ile 
            20                  25                  30          


Lys Ala Asp Lys Glu Lys Gly Phe Arg Val Asp Lys Ile Val Asp Gln 
        35                  40                  45              


Leu Gln Gln Leu Met Gln Val Tyr Asp Leu Ala Ala Leu Arg Asp Tyr 
    50                  55                  60                  


Trp Ser Tyr Leu Glu Arg Arg Leu Phe Ser Arg Leu Glu Asp Ile Tyr 
65                  70                  75                  80  


Arg Pro Thr Ile His Lys Leu Lys Thr Ser Leu Phe Arg Phe Tyr Leu 
                85                  90                  95      


Val Tyr Thr Ile Gln Thr Asn Arg Asn Asp Lys Ala Gln Glu Phe Phe 
            100                 105                 110         


Ala Lys Gln Ala Thr Glu Leu Gln Asn Gln Ala Glu Trp Lys Asp Trp 
        115                 120                 125             


Phe Val Leu Pro Phe Leu Pro Ser Pro Asp Thr Asn Pro Thr Phe Ala 
    130                 135                 140                 


Thr Tyr Phe Ser Arg Gln Trp Ala Asp Thr Phe Ile Val Ser Leu His 
145                 150                 155                 160 


Asn Phe Leu Ser Val Leu Phe Gln Cys Met Pro Val Pro Val Ile Leu 
                165                 170                 175     


Asn Phe Asp Ala Glu Cys Gln Arg Thr Asn Gln Val Gln Glu Glu Asn 
            180                 185                 190         


Glu Val Leu Arg Gln Lys Leu Phe Ala Leu Gln Ala Glu Ile His Arg 
        195                 200                 205             


Leu Lys Lys Glu Glu Gln Gln Pro Glu Glu Glu Glu Ala Leu Val Gln 
    210                 215                 220                 


His Lys Leu Pro Pro Tyr Val Ser Asn Met Asp Arg Leu Gly Asp Ser 
225                 230                 235                 240 


Glu Leu Ala Met Val Cys Ser Gln Arg Asn Ala Ser Leu Ser Gln Ser 
                245                 250                 255     


Pro Arg Val Gly Phe Leu Ser Ser Leu Leu Pro Gln Ser Lys Lys Ser 
            260                 265                 270         


Pro Ser Arg Leu Ser Pro Ala Gln Gly Pro Pro Gln Pro Gln Ser Ser 
        275                 280                 285             


Ala Lys Lys Glu Ser Phe Gly Gly Gln Gly Thr Lys Gly Lys Asp Pro 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asp Gly Lys Ser Leu Leu Ser Gly Leu Ala Thr 
305                 310                 315                 320 


Gly Glu Ser Gly Trp Ser Gln His Arg Gln Arg Arg Leu Gln Asp His 
                325                 330                 335     


Gly Lys Glu Arg Lys Glu Leu Phe Ser Thr Thr Thr Ser Gln Cys Ala 
            340                 345                 350         


Glu Lys Lys Pro Glu Ala Ser Gly Pro Glu Ala Glu Pro Cys Pro Glu 
        355                 360                 365             


Leu His Thr Glu Pro Val Glu Pro Leu Thr Arg Ala Ser Ser Ala Gly 
    370                 375                 380                 


Pro Glu Gly Gly Gly Val Arg Pro Glu Gln Pro Phe Ile Val Leu Gly 
385                 390                 395                 400 


Gln Glu Glu Tyr Gly Glu His His Ser Ser Ile Met His Cys Arg Val 
                405                 410                 415     


Asp Cys Ser Gly Arg Arg Val Ala Ser Leu Asp Val Asp Gly Val Ile 
            420                 425                 430         


Lys Val Trp Ser Phe Asn Pro Ile Met Gln Thr Lys Ala Ser Ser Ile 
        435                 440                 445             


Ser Lys Ser Pro Leu Leu Ser Leu Glu Trp Ala Thr Lys Arg Asp Arg 
    450                 455                 460                 


Leu Leu Leu Leu Gly Ser Gly Val Gly Thr Val Arg Leu Tyr Asp Thr 
465                 470                 475                 480 


Glu Ala Lys Lys Asn Leu Cys Glu Ile Asn Ile Asn Asp Asn Met Pro 
                485                 490                 495     


Arg Ile Leu Ser Leu Ala Cys Ser Pro Asn Gly Ala Ser Phe Val Cys 
            500                 505                 510         


Ser Ala Ala Ala Pro Ser Leu Thr Ser Gln Val Asp Phe Ser Ala Pro 
        515                 520                 525             


Asp Ile Gly Ser Lys Gly Met Asn Gln Val Pro Gly Arg Leu Leu Leu 
    530                 535                 540                 


Trp Asp Thr Lys Thr Met Lys Gln Gln Leu Gln Phe Ser Leu Asp Pro 
545                 550                 555                 560 


Glu Pro Ile Ala Ile Asn Cys Thr Ala Phe Asn His Asn Gly Asn Leu 
                565                 570                 575     


Leu Val Thr Gly Ala Ala Asp Gly Val Ile Arg Leu Phe Asp Met Gln 
            580                 585                 590         


Gln His Glu Cys Ala Met Ser Trp Arg Ala His Tyr Gly Glu Val Tyr 
        595                 600                 605             


Ser Val Glu Phe Ser Tyr Asp Glu Asn Thr Val Tyr Ser Ile Gly Glu 
    610                 615                 620                 


Asp Gly Lys Phe Ile Gln Trp Asn Ile His Lys Ser Gly Leu Lys Val 
625                 630                 635                 640 


Ser Glu Tyr Ser Leu Pro Ser Asp Ala Thr Gly Pro Phe Val Leu Ser 
                645                 650                 655     


Gly Tyr Ser Gly Tyr Lys Gln Val Gln Val Pro Arg Gly Arg Leu Phe 
            660                 665                 670         


Ala Phe Asp Ser Glu Gly Asn Tyr Met Leu Thr Cys Ser Ala Thr Gly 
        675                 680                 685             


Gly Val Ile Tyr Lys Leu Gly Gly Asp Glu Lys Val Leu Glu Ser Cys 
    690                 695                 700                 


Leu Ser Leu Gly Gly His Arg Ala Pro Val Val Thr Val Asp Trp Ser 
705                 710                 715                 720 


Thr Ala Met Asp Cys Gly Thr Cys Leu Thr Ala Ser Met Asp Gly Lys 
                725                 730                 735     


Ile Lys Leu Thr Thr Leu Leu Ala His Lys Ala 
            740                 745         


<210>  11
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  11
atgggtctgc tccttcccct ggcactctgc atcctagtcc tgtgctgcgg agcaatgtct       60

ccaccccagc tggccctcaa cccctcggct ctgctctccc ggggctgcaa tgactcagat      120

gtgctggcag ttgcaggctt tgccctgcgg gatattaaca aagacagaaa ggatggctat      180

gtgctgagac tcaaccgagt gaacgacgcc caggaataca gacggggtgg cctgggatct      240

ctgttctatc ttacactgga tgtgctagag actgactgcc atgtgctcag aaagaaggca      300

tggcaagact gtggaatgag gatatttttt gaatcagttt atggtcaatg caaagcaata      360

ttttatatga acaacccaag tagagttctc tatttagctg cttataactg tactcttcgc      420

ccagtttcaa aaaaaaagat ttacatgacg tgccctgact gcccaagctc catacccact      480

gactcttcca atcaccaagt gctggaggct gccaccgagt ctcttgcgaa atacaacaat      540

gagaacacat ccaagcagta ttctctcttc aaagtcacca gggcttctag ccagtgggtg      600

gtcggccctt cttactttgt ggaatactta attaaagaat caccatgtac taaatcccag      660

gccagcagct gttcacttca gtcctccgac tctgtgcctg ttggtctttg caaaggttct      720

ctgactcgaa cacactggga aaagtttgtc tctgtgactt gtgacttctt tgaatcacag      780

gctccagcca ctggaagtga aaactctgct gttaaccaga aacctacaaa ccttcccaag      840

gtggaagaat cccagcagaa aaacaccccc ccaacagact ccccctccaa agctgggcca      900

agaggatctg tccaatatct tcctgacttg gatgataaaa attcccagga aaagggccct      960

caggaggcct ttcctgtgca tctggaccta accacgaatc cccagggaga aaccctggat     1020

atttccttcc tcttcctgga gcctatggag gagaagctgg tggtcctgcc tttccccaaa     1080

gaaaaagcac gcactgctga gtgcccaggg ccagcccaga atgccagccc tcttgtcctt     1140

ccgccatga                                                             1149


<210>  12
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  13
<211>  4785
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaagttat atgtatttct ggttaacact ggaactactc taacatttga cactgaactt       60

acagtgcaaa ctgtggcaga ccttaagcat gccattcaaa gcaaatacaa gattgctatt      120

caacaccagg tgctggtggt caatggagga gaatgcatgg ctgcagatcg aagagtgtgt      180

acctacagtg ctgggacgga tacaaatcca atttttcttt ttaacaaaga aatgatctta      240

tgtgatcgtc cacctgctat tcctaaaact accttttcga cagaaaatga catggaaata      300

aaagttgaag aatctcttat gatgcctgca gtttttcata ctgttgcttc aaggacacag      360

cttgcattgg aaatgtatga agttgccaag aaactttgtt ctttttgtga aggtcttgta      420

catgatgaac atcttcaaca ccaaggctgg gctgcaatca tggccaacct ggaggactgt      480

tcaaattcat accaaaagct acttttcaag tttgaaagta tttattcaaa ttatctgcag      540

tccatagaag acatcaagtt aaaacttact catttaggaa ctgcagtttc agtaatggcc      600

aagattccac tgttggagtg cctaaccaga catagttaca gagaatgttt gggaagactg      660

gattctttac ctgaacatga agactcagaa aaagctgaga tgaaaagatc cactgaactg      720

gtgctctctc ctgatatgcc tagaacaact aacgaatctt tgttaacctc atttcccaag      780

tcagtggaac atgtgtcccc agataccgca gatgctgaaa gtggcaaaga aattagggaa      840

tcttgtcaaa gtactgttca tcagcaagat gaaactacga ttgacactaa agatggtgat      900

ctgccctttt ttaatgtctc tttgttagac tggataaatg ttcaagatag acctaatgat      960

gtggaatctt tggtcaggaa gtgctttgat tctatgagca ggcttgatcc aaggattatt     1020

cgaccattta tagcagaatg ccgtcaaact attgccaaac ttgataatca gaatatgaaa     1080

gccattaaag gacttgaaga tcggctctac gccctggacc agatgattgc tagctgtggc     1140

cgactggtga atgaacagaa agagcttgct cagggatttt tagctaatca gaagagagct     1200

gaaaacttaa aggatgcatc tgtattacct gatttatgcc tgagtcacgc aaatcagttg     1260

atgattatgt tgcaaaatca tagaaaactg ttagatatta agcagaagtg taccactgcc     1320

aaacaagaac tagcaaataa cctacatgtc agactgaagt ggtgttgctt tgtaatgctt     1380

catgctgatc aagatggaga gaagttacaa gctttgctcc gcctcgtaat agagctgtta     1440

gaaagagtca aaattgttga agctcttagt acagttcctc agatgtactg cttagctgtt     1500

gttgaggttg taagaagaaa aatgttcata aaacactaca gggagtgggc tggtgcttta     1560

gtcaaagatg gaaagagatt atatgaagca gaaaaatcaa aaagggaatc ctttgggaaa     1620

ttatttagga agtctttttt aagaaatcgt ctgtttaggg gactggactc ctggccccct     1680

tccttttgta ctcaaaagcc tcgaaagttt gactgtgaac ttccagatat ttcattaaaa     1740

gatttacagt ttctgcaatc attttgtcct tcggaagttc agccattcct cagggttccc     1800

ttactttgtg actttgaacc tctacaccag catgtacttg ctctacataa tttggtaaaa     1860

gcagcacaaa gtttggatga aatgtcacag accattacag atctactgag tgaacaaaag     1920

gcatctgtga gtcagacatc cccacagtct gcttcttcac caaggatgga aagtacagca     1980

ggaattacaa ctactacctc accgagaact cctccaccac tgactgttca ggatccctta     2040

tgtcctgcag tttgtccctt agaagaatta tctccagata gtattgatgc acatacgttt     2100

gattttgaaa ctattcccca tccaaacata gaacagacta ttcaccaagt ttctttagac     2160

ttggattcat tagcagaaag tcctgaatca gattttatgt ctgctgtgaa tgagtttgta     2220

atagaagaaa atttgtcgtc tcctaatcct ataagtgatc cacaaagccc agaaatgatg     2280

gtggaatcac tttattcatc agttatcaat gcgatagaca gtagacgaat gcaggataca     2340

aatgtatgtg gtaaggagga ttttggagat catacttctc tgaatgtcca gttggaaaga     2400

tgtagagttg ttgcccaaga ctctcacttc agtatacaaa ccattaagga agacctttgc     2460

cactttagaa catttgtaca aaaagaacag tgtgacttct caaattcatt aaaatgtaca     2520

gcagtagaaa taagaaacat tattgaaaaa gtaaaatgtt ctctggaaat aacactaaaa     2580

gaaaaacatc aaaaagaact actgtcttta aaaaatgaat atgaaggtaa acttgacgga     2640

ctaataaagg aaactgaaga gaatgaaaac aaaattaaaa aattgaaggg agagttagta     2700

tgccttgagg aggttttaca aaataaagat aatgaatttg ctttggttaa acatgaaaaa     2760

gaagctgtaa tctgcctgca gaatgaaaag gatcagaagt tgttagagat ggaaaatata     2820

atgcactctc aaaattgtga aattaaagaa ctgaagcagt cacgagaaat agtgttagaa     2880

gacttaaaaa agctccatgt tgaaaatgat gagaagttac agttattgag ggcagaactt     2940

cagtccttgg agcaaagtca tctaaaggaa ttagaggaca cacttcaggt taggcacata     3000

caagagtttg agaaggttat gacagaccac agagtttctt tggaggaatt aaaaaaggaa     3060

aaccaacaaa taattaatca aatacaagaa tctcatgctg aaattatcca ggaaaaagaa     3120

aaacagttac aggaattaaa actcaaggtt tctgatttgt cagacacgag atgcaagtta     3180

gaggttgaac ttgcgttgaa ggaagcagaa actgatgaaa taaaaatttt gctggaagaa     3240

agcagagccc agcagaagga gaccttgaaa tctcttcttg aacaagagac agaaaatttg     3300

agaacagaaa ttagtaaact caaccaaaag attcaggata ataatgaaaa ttatcaggtg     3360

ggcttagcag agctaagaac tttaatgaca attgaaaaag atcagtgtat ttccgagtta     3420

attagtagac atgaagaaga atctaatata cttaaagctg aattaaacaa agtaacatct     3480

ttgcataacc aagcatttga aatagaaaaa aacctaaaag aacaaataat tgaactgcag     3540

agtaaattgg attcagaatt gagtgctctt gaaagacaaa aagatgaaaa aattacccaa     3600

caagaagaga aatacgaagc tattatccag aaccttgaga aagacagaca aaaattggtc     3660

agcagccagg agcaagacag agaacagtta attcagaagc ttaattgtga aaaagatgaa     3720

gctattcaga ctgccctaaa agaatttaaa ttggagagag aagttgttga gaaagagtta     3780

ttagaaaaag ttaaacatct tgagaatcaa atagcaaaaa gtcctgccat tgactctacc     3840

agaggagatt cttcaagctt agttgctgaa cttcaagaaa agcttcagga agaaaaagct     3900

aagtttctag aacaacttga agagcaagaa aaaagaaaga atgaagaaat gcaaaatgtt     3960

cgaacatctt tgattgcgga acaacagacc aattttaaca ctgttttaac aagagagaaa     4020

atgagaaaag aaaacataat aaatgatctt agtgataagt tgaaaagtac aatgcagcaa     4080

caagaacggg ataaagattt gatagagtca ctttctgaag atcgagctcg tttgcttgag     4140

gaaaagaaaa agcttgaaga agaagtcagt aagttgcgta gtagcagttt tgttccttca     4200

ccatatgtag ctacagcccc agaactttat ggagcttgtg cacctgaact cccaggtgaa     4260

tcagatagat ccgctgtgga aacagcagat gaaggaagag tggattcagc aatggagaca     4320

agcatgatgt ctgtacaaga aaatattcat atgttgtctg aagaaaaaca gcggataatg     4380

ctgttagaac gaacattgca attgaaagaa gaagaaaata aacggttaaa tcaaagactg     4440

atgtctcaga gcatgtcttc agtatcttca aggcattctg aaaagatagc tattagagat     4500

tttcaggtgg gagatttggt actcatcatc ctagacgaac gccatgacaa ttatgtgtta     4560

tttactgtta gtcctacttt atattttcta cattcagagt ctctacctgc cctggatctc     4620

aaaccaggtg agggtgcttc aggtgcatct agaagaccct gggtacttgg aaaagtaatg     4680

gaaaaagaat actgtcaagc caaaaaggca caaaacagat ttaaagttcc tttggggaca     4740

aagttttaca gagtgaaagc cgtatcatgg aataagaaag tataa                     4785


<210>  14
<211>  1594
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Leu Tyr Val Phe Leu Val Asn Thr Gly Thr Thr Leu Thr Phe 
1               5                   10                  15      


Asp Thr Glu Leu Thr Val Gln Thr Val Ala Asp Leu Lys His Ala Ile 
            20                  25                  30          


Gln Ser Lys Tyr Lys Ile Ala Ile Gln His Gln Val Leu Val Val Asn 
        35                  40                  45              


Gly Gly Glu Cys Met Ala Ala Asp Arg Arg Val Cys Thr Tyr Ser Ala 
    50                  55                  60                  


Gly Thr Asp Thr Asn Pro Ile Phe Leu Phe Asn Lys Glu Met Ile Leu 
65                  70                  75                  80  


Cys Asp Arg Pro Pro Ala Ile Pro Lys Thr Thr Phe Ser Thr Glu Asn 
                85                  90                  95      


Asp Met Glu Ile Lys Val Glu Glu Ser Leu Met Met Pro Ala Val Phe 
            100                 105                 110         


His Thr Val Ala Ser Arg Thr Gln Leu Ala Leu Glu Met Tyr Glu Val 
        115                 120                 125             


Ala Lys Lys Leu Cys Ser Phe Cys Glu Gly Leu Val His Asp Glu His 
    130                 135                 140                 


Leu Gln His Gln Gly Trp Ala Ala Ile Met Ala Asn Leu Glu Asp Cys 
145                 150                 155                 160 


Ser Asn Ser Tyr Gln Lys Leu Leu Phe Lys Phe Glu Ser Ile Tyr Ser 
                165                 170                 175     


Asn Tyr Leu Gln Ser Ile Glu Asp Ile Lys Leu Lys Leu Thr His Leu 
            180                 185                 190         


Gly Thr Ala Val Ser Val Met Ala Lys Ile Pro Leu Leu Glu Cys Leu 
        195                 200                 205             


Thr Arg His Ser Tyr Arg Glu Cys Leu Gly Arg Leu Asp Ser Leu Pro 
    210                 215                 220                 


Glu His Glu Asp Ser Glu Lys Ala Glu Met Lys Arg Ser Thr Glu Leu 
225                 230                 235                 240 


Val Leu Ser Pro Asp Met Pro Arg Thr Thr Asn Glu Ser Leu Leu Thr 
                245                 250                 255     


Ser Phe Pro Lys Ser Val Glu His Val Ser Pro Asp Thr Ala Asp Ala 
            260                 265                 270         


Glu Ser Gly Lys Glu Ile Arg Glu Ser Cys Gln Ser Thr Val His Gln 
        275                 280                 285             


Gln Asp Glu Thr Thr Ile Asp Thr Lys Asp Gly Asp Leu Pro Phe Phe 
    290                 295                 300                 


Asn Val Ser Leu Leu Asp Trp Ile Asn Val Gln Asp Arg Pro Asn Asp 
305                 310                 315                 320 


Val Glu Ser Leu Val Arg Lys Cys Phe Asp Ser Met Ser Arg Leu Asp 
                325                 330                 335     


Pro Arg Ile Ile Arg Pro Phe Ile Ala Glu Cys Arg Gln Thr Ile Ala 
            340                 345                 350         


Lys Leu Asp Asn Gln Asn Met Lys Ala Ile Lys Gly Leu Glu Asp Arg 
        355                 360                 365             


Leu Tyr Ala Leu Asp Gln Met Ile Ala Ser Cys Gly Arg Leu Val Asn 
    370                 375                 380                 


Glu Gln Lys Glu Leu Ala Gln Gly Phe Leu Ala Asn Gln Lys Arg Ala 
385                 390                 395                 400 


Glu Asn Leu Lys Asp Ala Ser Val Leu Pro Asp Leu Cys Leu Ser His 
                405                 410                 415     


Ala Asn Gln Leu Met Ile Met Leu Gln Asn His Arg Lys Leu Leu Asp 
            420                 425                 430         


Ile Lys Gln Lys Cys Thr Thr Ala Lys Gln Glu Leu Ala Asn Asn Leu 
        435                 440                 445             


His Val Arg Leu Lys Trp Cys Cys Phe Val Met Leu His Ala Asp Gln 
    450                 455                 460                 


Asp Gly Glu Lys Leu Gln Ala Leu Leu Arg Leu Val Ile Glu Leu Leu 
465                 470                 475                 480 


Glu Arg Val Lys Ile Val Glu Ala Leu Ser Thr Val Pro Gln Met Tyr 
                485                 490                 495     


Cys Leu Ala Val Val Glu Val Val Arg Arg Lys Met Phe Ile Lys His 
            500                 505                 510         


Tyr Arg Glu Trp Ala Gly Ala Leu Val Lys Asp Gly Lys Arg Leu Tyr 
        515                 520                 525             


Glu Ala Glu Lys Ser Lys Arg Glu Ser Phe Gly Lys Leu Phe Arg Lys 
    530                 535                 540                 


Ser Phe Leu Arg Asn Arg Leu Phe Arg Gly Leu Asp Ser Trp Pro Pro 
545                 550                 555                 560 


Ser Phe Cys Thr Gln Lys Pro Arg Lys Phe Asp Cys Glu Leu Pro Asp 
                565                 570                 575     


Ile Ser Leu Lys Asp Leu Gln Phe Leu Gln Ser Phe Cys Pro Ser Glu 
            580                 585                 590         


Val Gln Pro Phe Leu Arg Val Pro Leu Leu Cys Asp Phe Glu Pro Leu 
        595                 600                 605             


His Gln His Val Leu Ala Leu His Asn Leu Val Lys Ala Ala Gln Ser 
    610                 615                 620                 


Leu Asp Glu Met Ser Gln Thr Ile Thr Asp Leu Leu Ser Glu Gln Lys 
625                 630                 635                 640 


Ala Ser Val Ser Gln Thr Ser Pro Gln Ser Ala Ser Ser Pro Arg Met 
                645                 650                 655     


Glu Ser Thr Ala Gly Ile Thr Thr Thr Thr Ser Pro Arg Thr Pro Pro 
            660                 665                 670         


Pro Leu Thr Val Gln Asp Pro Leu Cys Pro Ala Val Cys Pro Leu Glu 
        675                 680                 685             


Glu Leu Ser Pro Asp Ser Ile Asp Ala His Thr Phe Asp Phe Glu Thr 
    690                 695                 700                 


Ile Pro His Pro Asn Ile Glu Gln Thr Ile His Gln Val Ser Leu Asp 
705                 710                 715                 720 


Leu Asp Ser Leu Ala Glu Ser Pro Glu Ser Asp Phe Met Ser Ala Val 
                725                 730                 735     


Asn Glu Phe Val Ile Glu Glu Asn Leu Ser Ser Pro Asn Pro Ile Ser 
            740                 745                 750         


Asp Pro Gln Ser Pro Glu Met Met Val Glu Ser Leu Tyr Ser Ser Val 
        755                 760                 765             


Ile Asn Ala Ile Asp Ser Arg Arg Met Gln Asp Thr Asn Val Cys Gly 
    770                 775                 780                 


Lys Glu Asp Phe Gly Asp His Thr Ser Leu Asn Val Gln Leu Glu Arg 
785                 790                 795                 800 


Cys Arg Val Val Ala Gln Asp Ser His Phe Ser Ile Gln Thr Ile Lys 
                805                 810                 815     


Glu Asp Leu Cys His Phe Arg Thr Phe Val Gln Lys Glu Gln Cys Asp 
            820                 825                 830         


Phe Ser Asn Ser Leu Lys Cys Thr Ala Val Glu Ile Arg Asn Ile Ile 
        835                 840                 845             


Glu Lys Val Lys Cys Ser Leu Glu Ile Thr Leu Lys Glu Lys His Gln 
    850                 855                 860                 


Lys Glu Leu Leu Ser Leu Lys Asn Glu Tyr Glu Gly Lys Leu Asp Gly 
865                 870                 875                 880 


Leu Ile Lys Glu Thr Glu Glu Asn Glu Asn Lys Ile Lys Lys Leu Lys 
                885                 890                 895     


Gly Glu Leu Val Cys Leu Glu Glu Val Leu Gln Asn Lys Asp Asn Glu 
            900                 905                 910         


Phe Ala Leu Val Lys His Glu Lys Glu Ala Val Ile Cys Leu Gln Asn 
        915                 920                 925             


Glu Lys Asp Gln Lys Leu Leu Glu Met Glu Asn Ile Met His Ser Gln 
    930                 935                 940                 


Asn Cys Glu Ile Lys Glu Leu Lys Gln Ser Arg Glu Ile Val Leu Glu 
945                 950                 955                 960 


Asp Leu Lys Lys Leu His Val Glu Asn Asp Glu Lys Leu Gln Leu Leu 
                965                 970                 975     


Arg Ala Glu Leu Gln Ser Leu Glu Gln Ser His Leu Lys Glu Leu Glu 
            980                 985                 990         


Asp Thr Leu Gln Val Arg His Ile  Gln Glu Phe Glu Lys  Val Met Thr 
        995                 1000                 1005             


Asp His  Arg Val Ser Leu Glu  Glu Leu Lys Lys Glu  Asn Gln Gln 
    1010                 1015                 1020             


Ile Ile  Asn Gln Ile Gln Glu  Ser His Ala Glu Ile  Ile Gln Glu 
    1025                 1030                 1035             


Lys Glu  Lys Gln Leu Gln Glu  Leu Lys Leu Lys Val  Ser Asp Leu 
    1040                 1045                 1050             


Ser Asp  Thr Arg Cys Lys Leu  Glu Val Glu Leu Ala  Leu Lys Glu 
    1055                 1060                 1065             


Ala Glu  Thr Asp Glu Ile Lys  Ile Leu Leu Glu Glu  Ser Arg Ala 
    1070                 1075                 1080             


Gln Gln  Lys Glu Thr Leu Lys  Ser Leu Leu Glu Gln  Glu Thr Glu 
    1085                 1090                 1095             


Asn Leu  Arg Thr Glu Ile Ser  Lys Leu Asn Gln Lys  Ile Gln Asp 
    1100                 1105                 1110             


Asn Asn  Glu Asn Tyr Gln Val  Gly Leu Ala Glu Leu  Arg Thr Leu 
    1115                 1120                 1125             


Met Thr  Ile Glu Lys Asp Gln  Cys Ile Ser Glu Leu  Ile Ser Arg 
    1130                 1135                 1140             


His Glu  Glu Glu Ser Asn Ile  Leu Lys Ala Glu Leu  Asn Lys Val 
    1145                 1150                 1155             


Thr Ser  Leu His Asn Gln Ala  Phe Glu Ile Glu Lys  Asn Leu Lys 
    1160                 1165                 1170             


Glu Gln  Ile Ile Glu Leu Gln  Ser Lys Leu Asp Ser  Glu Leu Ser 
    1175                 1180                 1185             


Ala Leu  Glu Arg Gln Lys Asp  Glu Lys Ile Thr Gln  Gln Glu Glu 
    1190                 1195                 1200             


Lys Tyr  Glu Ala Ile Ile Gln  Asn Leu Glu Lys Asp  Arg Gln Lys 
    1205                 1210                 1215             


Leu Val  Ser Ser Gln Glu Gln  Asp Arg Glu Gln Leu  Ile Gln Lys 
    1220                 1225                 1230             


Leu Asn  Cys Glu Lys Asp Glu  Ala Ile Gln Thr Ala  Leu Lys Glu 
    1235                 1240                 1245             


Phe Lys  Leu Glu Arg Glu Val  Val Glu Lys Glu Leu  Leu Glu Lys 
    1250                 1255                 1260             


Val Lys  His Leu Glu Asn Gln  Ile Ala Lys Ser Pro  Ala Ile Asp 
    1265                 1270                 1275             


Ser Thr  Arg Gly Asp Ser Ser  Ser Leu Val Ala Glu  Leu Gln Glu 
    1280                 1285                 1290             


Lys Leu  Gln Glu Glu Lys Ala  Lys Phe Leu Glu Gln  Leu Glu Glu 
    1295                 1300                 1305             


Gln Glu  Lys Arg Lys Asn Glu  Glu Met Gln Asn Val  Arg Thr Ser 
    1310                 1315                 1320             


Leu Ile  Ala Glu Gln Gln Thr  Asn Phe Asn Thr Val  Leu Thr Arg 
    1325                 1330                 1335             


Glu Lys  Met Arg Lys Glu Asn  Ile Ile Asn Asp Leu  Ser Asp Lys 
    1340                 1345                 1350             


Leu Lys  Ser Thr Met Gln Gln  Gln Glu Arg Asp Lys  Asp Leu Ile 
    1355                 1360                 1365             


Glu Ser  Leu Ser Glu Asp Arg  Ala Arg Leu Leu Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Leu  Glu Glu Glu Val Ser  Lys Leu Arg Ser Ser  Ser Phe Val 
    1385                 1390                 1395             


Pro Ser  Pro Tyr Val Ala Thr  Ala Pro Glu Leu Tyr  Gly Ala Cys 
    1400                 1405                 1410             


Ala Pro  Glu Leu Pro Gly Glu  Ser Asp Arg Ser Ala  Val Glu Thr 
    1415                 1420                 1425             


Ala Asp  Glu Gly Arg Val Asp  Ser Ala Met Glu Thr  Ser Met Met 
    1430                 1435                 1440             


Ser Val  Gln Glu Asn Ile His  Met Leu Ser Glu Glu  Lys Gln Arg 
    1445                 1450                 1455             


Ile Met  Leu Leu Glu Arg Thr  Leu Gln Leu Lys Glu  Glu Glu Asn 
    1460                 1465                 1470             


Lys Arg  Leu Asn Gln Arg Leu  Met Ser Gln Ser Met  Ser Ser Val 
    1475                 1480                 1485             


Ser Ser  Arg His Ser Glu Lys  Ile Ala Ile Arg Asp  Phe Gln Val 
    1490                 1495                 1500             


Gly Asp  Leu Val Leu Ile Ile  Leu Asp Glu Arg His  Asp Asn Tyr 
    1505                 1510                 1515             


Val Leu  Phe Thr Val Ser Pro  Thr Leu Tyr Phe Leu  His Ser Glu 
    1520                 1525                 1530             


Ser Leu  Pro Ala Leu Asp Leu  Lys Pro Gly Glu Gly  Ala Ser Gly 
    1535                 1540                 1545             


Ala Ser  Arg Arg Pro Trp Val  Leu Gly Lys Val Met  Glu Lys Glu 
    1550                 1555                 1560             


Tyr Cys  Gln Ala Lys Lys Ala  Gln Asn Arg Phe Lys  Val Pro Leu 
    1565                 1570                 1575             


Gly Thr  Lys Phe Tyr Arg Val  Lys Ala Val Ser Trp  Asn Lys Lys 
    1580                 1585                 1590             


Val 
    


<210>  15
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  15
atggtgttgc tcaccgcggt cctcctgctg ctggccgcct atgcggggcc ggcccagagc       60

ctgggctcct tcgtgcactg cgagccctgc gacgagaaag ccctctccat gtgccccccc      120

agccccctgg gctgcgagct ggtcaaggag ccgggctgcg gctgctgcat gacctgcgcc      180

ctggccgagg ggcagtcgtg cggcgtctac accgagcgct gcgcccaggg gctgcgctgc      240

ctcccccggc aggacgagga gaagccgctg cacgccctgc tgcacggccg cggggtttgc      300

ctcaacgaaa agagctaccg cgagcaagtc aagatcgaga gagactcccg tgagcacgag      360

gagcccacca cctctgagat ggccgaggag acctactccc ccaagatctt ccggcccaaa      420

cacacccgca tctccgagct gaaggctgaa gcagtgaaga aggaccgcag aaagaagctg      480

acccagtcca agtttgtcgg gggagccgag aacactgccc acccccggat catctctgca      540

cctgagatga gacaggagtc tgagcagggc ccctgccgca gacacatgga ggcttccctg      600

caggagctca aagccagccc acgcatggtg ccccgtgctg tgtacctgcc caattgtgac      660

cgcaaaggat tctacaagag aaagcagtgc aaaccttccc gtggccgcaa acgtggcatc      720

tgctggtgcg tggacaagta cgggatgaag ctgccaggca tggagtacgt tgacggggac      780

tttcagtgcc acaccttcga cagcagcaac gttgagtga                             819


<210>  16
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  17
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  17
atgagggtag caggtgctgc aaagttggtg gtagctgtgg cagtgttttt actgacattt       60

tatgttattt ctcaagtatt tgaaataaaa atggatgcaa gtttaggaaa tctatttgca      120

agatcagcat tggacacagc tgcacgttct acaaagcctc ccagatataa gtgtgggatc      180

tcaaaagctt gccctgagaa gcattttgct tttaaaatgg caagtggagc agccaacgtg      240

gtgggaccca aaatctgcct ggaagataat gttttaatga gtggtgttaa gaataatgtt      300

ggaagaggga tcaatgttgc cttggcaaat ggaaaaacag gagaagtatt agacactaaa      360

tattttgaca tgtggggagg agatgtggca ccatttattg agtttctgaa ggccatacaa      420

gatggaacaa tagttttaat gggaacatac gatgatggag caaccaaact caatgatgag      480

gcacggcggc tcattgctga tttggggagc acatctatta ctaatcttgg ttttagagac      540

aactgggtct tctgtggtgg gaagggcatt aagacaaaaa gcccttttga acagcacata      600

aagaacaata aggatacaaa caaatatgaa ggatggcctg aagttgtaga aatggaagga      660

tgcatccccc agaagcaaga ctaa                                             684


<210>  18
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Val Ala Gly Ala Ala Lys Leu Val Val Ala Val Ala Val Phe 
1               5                   10                  15      


Leu Leu Thr Phe Tyr Val Ile Ser Gln Val Phe Glu Ile Lys Met Asp 
            20                  25                  30          


Ala Ser Leu Gly Asn Leu Phe Ala Arg Ser Ala Leu Asp Thr Ala Ala 
        35                  40                  45              


Arg Ser Thr Lys Pro Pro Arg Tyr Lys Cys Gly Ile Ser Lys Ala Cys 
    50                  55                  60                  


Pro Glu Lys His Phe Ala Phe Lys Met Ala Ser Gly Ala Ala Asn Val 
65                  70                  75                  80  


Val Gly Pro Lys Ile Cys Leu Glu Asp Asn Val Leu Met Ser Gly Val 
                85                  90                  95      


Lys Asn Asn Val Gly Arg Gly Ile Asn Val Ala Leu Ala Asn Gly Lys 
            100                 105                 110         


Thr Gly Glu Val Leu Asp Thr Lys Tyr Phe Asp Met Trp Gly Gly Asp 
        115                 120                 125             


Val Ala Pro Phe Ile Glu Phe Leu Lys Ala Ile Gln Asp Gly Thr Ile 
    130                 135                 140                 


Val Leu Met Gly Thr Tyr Asp Asp Gly Ala Thr Lys Leu Asn Asp Glu 
145                 150                 155                 160 


Ala Arg Arg Leu Ile Ala Asp Leu Gly Ser Thr Ser Ile Thr Asn Leu 
                165                 170                 175     


Gly Phe Arg Asp Asn Trp Val Phe Cys Gly Gly Lys Gly Ile Lys Thr 
            180                 185                 190         


Lys Ser Pro Phe Glu Gln His Ile Lys Asn Asn Lys Asp Thr Asn Lys 
        195                 200                 205             


Tyr Glu Gly Trp Pro Glu Val Val Glu Met Glu Gly Cys Ile Pro Gln 
    210                 215                 220                 


Lys Gln Asp 
225         


<210>  19
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  19
atgctgcctg cagccacagc ctccctcctg gggcccctcc tcactgcctg cgccctgctg       60

ccttttgccc agggccagac ccccaactac accagacccg tgttcctgtg cggaggggat      120

gtgaaggggg aatcaggtta cgtggcaagt gaggggttcc ccaacctcta cccccctaat      180

aaggagtgca tctggaccat aacggtcccc gagggccaga ctgtgtccct ctcattccga      240

gtcttcgacc tggagctgca ccccgcctgc cgctacgatg ctctggaggt cttcgctggg      300

tctgggactt ccggccagcg gctcggacgc ttttgtggga ccttccggcc tgcgccccta      360

gtcgcccccg gcaaccaggt gaccctgagg atgacgacgg atgagggcac aggaggacga      420

ggcttcctgc tctggtacag cgggcgggcc acctcgggca ctgagcacca attttgcggg      480

gggcggctgg agaaggccca gggaaccctg accacgccca actggcccga gtccgattac      540

cccccgggca tcagctgttc ctggcacatc atcgcgcccc cggaccaggt catcgcgctg      600

accttcgaga agtttgacct ggagccggac acctactgcc gctatgactc ggtcagcgtg      660

ttcaacggag ccgtgagcga cgactcccgg aggctgggga agttctgcgg cgacgcagtc      720

ccgggctcca tctcctccga agggaatgaa ctcctcgtcc agttcgtctc agatctcagt      780

gtcaccgctg atggcttctc agcctcctac aagaccctgc cgcggggcac tgccaaagaa      840

gggcaagggc ccggccccaa acggggaact gagcctaaag tcaagctgcc ccccaagtcc      900

caacctccgg agaaaacaga ggaatctcct tcagcccctg atgcacccac ctgcccaaag      960

cagtgccgcc ggacaggcac cttgcagagc aacttctgtg ccagcagcct tgtggtgact     1020

gcgacagtga agtccatggt tcgggagcca ggggagggcc ttgccgtgac tgtcagtctt     1080

attggtgctt ataaaactgg aggactggac ctgccttctc cacccactgg tgcctccctg     1140

aagttttacg tgccttgcaa gcagtgcccc cccatgaaga aaggagtcag ttatctgctg     1200

atgggccagg tagaagagaa cagaggcccc gtccttcctc cagagagctt tgtggttctc     1260

caccggccca accaggacca gatcctcacc aacctaagca agaggaagtg cccctctcaa     1320

cctgtgcggg ctgctgcgtc ccaggactga                                      1350


<210>  20
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Pro Ala Ala Thr Ala Ser Leu Leu Gly Pro Leu Leu Thr Ala 
1               5                   10                  15      


Cys Ala Leu Leu Pro Phe Ala Gln Gly Gln Thr Pro Asn Tyr Thr Arg 
            20                  25                  30          


Pro Val Phe Leu Cys Gly Gly Asp Val Lys Gly Glu Ser Gly Tyr Val 
        35                  40                  45              


Ala Ser Glu Gly Phe Pro Asn Leu Tyr Pro Pro Asn Lys Glu Cys Ile 
    50                  55                  60                  


Trp Thr Ile Thr Val Pro Glu Gly Gln Thr Val Ser Leu Ser Phe Arg 
65                  70                  75                  80  


Val Phe Asp Leu Glu Leu His Pro Ala Cys Arg Tyr Asp Ala Leu Glu 
                85                  90                  95      


Val Phe Ala Gly Ser Gly Thr Ser Gly Gln Arg Leu Gly Arg Phe Cys 
            100                 105                 110         


Gly Thr Phe Arg Pro Ala Pro Leu Val Ala Pro Gly Asn Gln Val Thr 
        115                 120                 125             


Leu Arg Met Thr Thr Asp Glu Gly Thr Gly Gly Arg Gly Phe Leu Leu 
    130                 135                 140                 


Trp Tyr Ser Gly Arg Ala Thr Ser Gly Thr Glu His Gln Phe Cys Gly 
145                 150                 155                 160 


Gly Arg Leu Glu Lys Ala Gln Gly Thr Leu Thr Thr Pro Asn Trp Pro 
                165                 170                 175     


Glu Ser Asp Tyr Pro Pro Gly Ile Ser Cys Ser Trp His Ile Ile Ala 
            180                 185                 190         


Pro Pro Asp Gln Val Ile Ala Leu Thr Phe Glu Lys Phe Asp Leu Glu 
        195                 200                 205             


Pro Asp Thr Tyr Cys Arg Tyr Asp Ser Val Ser Val Phe Asn Gly Ala 
    210                 215                 220                 


Val Ser Asp Asp Ser Arg Arg Leu Gly Lys Phe Cys Gly Asp Ala Val 
225                 230                 235                 240 


Pro Gly Ser Ile Ser Ser Glu Gly Asn Glu Leu Leu Val Gln Phe Val 
                245                 250                 255     


Ser Asp Leu Ser Val Thr Ala Asp Gly Phe Ser Ala Ser Tyr Lys Thr 
            260                 265                 270         


Leu Pro Arg Gly Thr Ala Lys Glu Gly Gln Gly Pro Gly Pro Lys Arg 
        275                 280                 285             


Gly Thr Glu Pro Lys Val Lys Leu Pro Pro Lys Ser Gln Pro Pro Glu 
    290                 295                 300                 


Lys Thr Glu Glu Ser Pro Ser Ala Pro Asp Ala Pro Thr Cys Pro Lys 
305                 310                 315                 320 


Gln Cys Arg Arg Thr Gly Thr Leu Gln Ser Asn Phe Cys Ala Ser Ser 
                325                 330                 335     


Leu Val Val Thr Ala Thr Val Lys Ser Met Val Arg Glu Pro Gly Glu 
            340                 345                 350         


Gly Leu Ala Val Thr Val Ser Leu Ile Gly Ala Tyr Lys Thr Gly Gly 
        355                 360                 365             


Leu Asp Leu Pro Ser Pro Pro Thr Gly Ala Ser Leu Lys Phe Tyr Val 
    370                 375                 380                 


Pro Cys Lys Gln Cys Pro Pro Met Lys Lys Gly Val Ser Tyr Leu Leu 
385                 390                 395                 400 


Met Gly Gln Val Glu Glu Asn Arg Gly Pro Val Leu Pro Pro Glu Ser 
                405                 410                 415     


Phe Val Val Leu His Arg Pro Asn Gln Asp Gln Ile Leu Thr Asn Leu 
            420                 425                 430         


Ser Lys Arg Lys Cys Pro Ser Gln Pro Val Arg Ala Ala Ala Ser Gln 
        435                 440                 445             


Asp 
    


<210>  21
<211>  303
<212>  DNA
<213>  Homo sapiens

<400>  21
atgaagctgc tcgcagcaac tgtgctactc ctcaccatct gcagccttga aggagctttg       60

gttcggagac aggcaaagga gccatgtgtg gagagcctgg tttctcagta cttccagacc      120

gtgactgact atggcaagga cctgatggag aaggtcaaga gcccagagct tcaggccgag      180

gccaagtctt actttgaaaa gtcaaaggag cagctgacac ccctgatcaa gaaggctgga      240

acggaactgg ttaacttctt gagctatttc gtggaacttg gaacacagcc tgccacccag      300

tga                                                                    303


<210>  22
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210>  23
<211>  1854
<212>  DNA
<213>  Homo sapiens

<400>  23
atgcccgccc tcagtcgctg ggccagcctg cccggcccca gcatgcggga ggcagccttc       60

atgtacagca cagcagtggc catcttcctg gtcatcctgg tggccgcact gcagggctcg      120

gctccccgtg agagccccct cccctatcac atccccctgg acccggaggg gtccctggag      180

ctctcatgga atgtcagcta cacccaggag gccatccatt tccagctcct ggtgcggagg      240

ctcaaggctg gcgtcctgtt tgggatgtcc gaccgtggcg agcttgagaa cgcagatctc      300

gtggtgctct ggaccgatgg ggacactgcc tattttgcgg acgcctggag tgaccagaag      360

gggcagatcc acctggatcc ccagcaggac taccagctgc tgcaggtgca gaggacccca      420

gaaggcctga ccctgctttt caagaggccc tttggcacct gcgaccccaa ggattacctc      480

attgaagacg gcactgtcca cttggtctac gggatcctgg aggagccgtt ccggtcactg      540

gaggccatca acggctcggg cctgcagatg gggctgcaga gggtgcagct cctgaagccc      600

aatatccccg aaccggagtt gccctcagac gcgtgcacca tggaggtcca agctcccaat      660

atccagatcc ccagccagga gaccacgtac tggtgctaca ttaaggagct tccaaagggc      720

ttctctcggc accacattat caagtacgag cccatcgtca ccaagggcaa tgaggccctt      780

gtccaccaca tggaagtctt ccagtgcgcc cccgagatgg acagcgtccc ccacttcagc      840

gggccctgcg actccaagat gaaacccgac cgcctcaact actgccgcca cgtgctggcc      900

gcctgggccc tgggtgccaa ggcattttac tacccagagg aagccggcct tgccttcggg      960

ggtccagggt cctccagata tctccgcctg gaagttcact accacaaccc actggtgata     1020

gaaggacgaa acgactcctc aggcatccgc ttgtactaca cagccaagct gcggcgcttc     1080

aacgcgggga tcatggagct gggactggtg tacacgccag tgatggccat tccaccacgg     1140

gagaccgcct tcatcctcac tggctactgc acggacaagt gcacccagct ggcactgcct     1200

ccctccggga tccacatctt cgcctctcag ctccacacac acctgactgg gagaaaggtg     1260

gtcacagtgc tggtccggga cggccgggag tgggagatcg tgaaccagga caatcactac     1320

agccctcact tccaggagat ccgcatgttg aagaaggtcg tgtcggtcca tccgggagat     1380

gtgctcatca cctcctgcac gtacaacaca gaagaccggg agctggccac agtggggggc     1440

ttcgggatcc tggaggagat gtgtgtcaac tacgtgcact actaccccca gacgcagctg     1500

gagctctgca agagcgctgt ggacgccggc ttcctgcaga agtacttcca cctcatcaac     1560

aggttcaaca acgaggatgt ctgcacctgc cctcaggcgt ccgtgtctca gcagttcacc     1620

tctgttccct ggaactcctt caaccgcgac gtactgaagg ccctgtacag cttcgcgccc     1680

atctccatgc actgcaacaa gtcctcagcc gtccgcttcc agggtgaatg gaacctgcag     1740

cccctgccca aggtcatctc cacactggaa gagcccaccc cacagtgccc caccagccag     1800

ggccgaagcc ctgctggccc caccgttgtc agcattggtg ggggcaaagg ctga           1854


<210>  24
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Ala Leu Ser Arg Trp Ala Ser Leu Pro Gly Pro Ser Met Arg 
1               5                   10                  15      


Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu Val Ile 
            20                  25                  30          


Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro Leu Pro 
        35                  40                  45              


Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser Trp Asn 
    50                  55                  60                  


Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val Arg Arg 
65                  70                  75                  80  


Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu Leu Glu 
                85                  90                  95      


Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala Tyr Phe 
            100                 105                 110         


Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp Pro Gln 
        115                 120                 125             


Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Thr Pro Glu Gly Leu Thr 
    130                 135                 140                 


Leu Leu Phe Lys Arg Pro Phe Gly Thr Cys Asp Pro Lys Asp Tyr Leu 
145                 150                 155                 160 


Ile Glu Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu Glu Pro 
                165                 170                 175     


Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu 
            180                 185                 190         


Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu Pro 
        195                 200                 205             


Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln Ile Pro 
    210                 215                 220                 


Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys Gly 
225                 230                 235                 240 


Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr Lys Gly 
                245                 250                 255     


Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro Glu 
            260                 265                 270         


Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met Lys 
        275                 280                 285             


Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala Leu 
    290                 295                 300                 


Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala Phe Gly 
305                 310                 315                 320 


Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr His Asn 
                325                 330                 335     


Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg Leu Tyr 
            340                 345                 350         


Tyr Thr Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu Leu Gly 
        355                 360                 365             


Leu Val Tyr Thr Pro Val Met Ala Ile Pro Pro Arg Glu Thr Ala Phe 
    370                 375                 380                 


Ile Leu Thr Gly Tyr Cys Thr Asp Lys Cys Thr Gln Leu Ala Leu Pro 
385                 390                 395                 400 


Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Thr His Leu Thr 
                405                 410                 415     


Gly Arg Lys Val Val Thr Val Leu Val Arg Asp Gly Arg Glu Trp Glu 
            420                 425                 430         


Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu Ile Arg 
        435                 440                 445             


Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu Ile Thr 
    450                 455                 460                 


Ser Cys Thr Tyr Asn Thr Glu Asp Arg Glu Leu Ala Thr Val Gly Gly 
465                 470                 475                 480 


Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr Tyr Pro 
                485                 490                 495     


Gln Thr Gln Leu Glu Leu Cys Lys Ser Ala Val Asp Ala Gly Phe Leu 
            500                 505                 510         


Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp Val Cys 
        515                 520                 525             


Thr Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Thr Ser Val Pro Trp 
    530                 535                 540                 


Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe Ala Pro 
545                 550                 555                 560 


Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln Gly Glu 
                565                 570                 575     


Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Thr Leu Glu Glu Pro 
            580                 585                 590         


Thr Pro Gln Cys Pro Thr Ser Gln Gly Arg Ser Pro Ala Gly Pro Thr 
        595                 600                 605             


Val Val Ser Ile Gly Gly Gly Lys Gly 
    610                 615         


<210>  25
<211>  1770
<212>  DNA
<213>  Homo sapiens

<400>  25
atgattaagt tccaggaaag ggtgacattc aaggacatag ctgttatctt caccaaggaa       60

gagctggcag tattggataa agcccagata aacctgtacc aagacgtgat gctggaaaac      120

ttcaggaact tcatctcagt ggatgggatt aaaaacaaca ttttgaatct tcagggaaag      180

gggttaattt acctttctca agaagagctt cattgctgga agatttggaa acaaaggatc      240

cgggatttaa gtgtgagtca ggattatatc atgaaccttc aagaacagtg ttccccacat      300

ttagaagatg tatccctctg tgaagagtgg gcaggcatgt ctcttcagat ttctgaaaat      360

gaaaactatg tagtaaatgc cattatcaaa aatcaagata tcacagcatg gcaaagcctg      420

acacaggttc ttactccaga atcttggagg aaagccaaca taatgaccga gccccagaaa      480

tctcagggaa gatataaggg aatttacgtg gaagagaaat tgtacagaca tgctcggcat      540

gatgagagcc tcaattggac ctcacgtgat catcatgagt cccaagaatg taaaggagag      600

gaccctggta gacaccccaa ctgtgggaaa aacttgggta tgaaatcaac agttgaacaa      660

catcatgcgg tccatgtttt accacagcct ttcacatgta ataactgtgg ggtggccttt      720

gcagatgata cagatcctcg tgtccatcac agcactcatc taggagaaaa atcttataaa      780

tgtgaccagt atggaaagaa cttaagtcag agccaatatc ttattgttca ttgtaaaacc      840

cactcaggag agactcccta tgaattccat gaatggccta caggctgcaa acagagctca      900

gaccttccca gatgtcagaa agtcccctca ggagacaatc cctacaaatg taaagaatgt      960

ggcaagggct tcaggtgcaa ctcctccctt cacaaccatc atcgagtcca cacaggggag     1020

atgccctaca aatgccacgt atgtgggaaa gcgtttggat ttaggtcact tccttgtatt     1080

catcagggag tacacacagg gaaaaagccc tacaaatgtg aagattgtgg gaagggcttt     1140

gaacagagct ccaaccttct tatccatcag agagtccaca ctggagagaa gccctacaaa     1200

tccagtgagt gtggcaagtg ctttagttca agctccgttc ttcaagtcca ctggaggttt     1260

cacacagggg agaaacctta taggtgtggt gagtgtggaa agggcttcag ccaaagtaca     1320

caccttcaca ttcaccagag agtccacaca ggggagaaac aatacaaatg caatgtgtgt     1380

ggaaaggatt ttgggtatag ttctgttctt cacactcatc agagagttca cactgcagaa     1440

aaaccatata aatgcgaagt gtgtggaaag tgctttagtt acagttcata ttttcacttc     1500

catcaaagca atcacacaag agagaaacca tataaatgtg atgagtgtgg taaaggcttc     1560

agttggaatt cagatcttaa tgttcatctc agagtccaca gaggacagag gccctgtaag     1620

tgtaaggcat gtggtaaggg cttcagtcgt aattcgcacc tccttgccca acagagagtg     1680

cgtatagata agacacagta cacacattgt gagcatggca aagaccttct gactcatcaa     1740

agactacatg agcagagaga aacattataa                                      1770


<210>  26
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ile Lys Phe Gln Glu Arg Val Thr Phe Lys Asp Ile Ala Val Ile 
1               5                   10                  15      


Phe Thr Lys Glu Glu Leu Ala Val Leu Asp Lys Ala Gln Ile Asn Leu 
            20                  25                  30          


Tyr Gln Asp Val Met Leu Glu Asn Phe Arg Asn Phe Ile Ser Val Asp 
        35                  40                  45              


Gly Ile Lys Asn Asn Ile Leu Asn Leu Gln Gly Lys Gly Leu Ile Tyr 
    50                  55                  60                  


Leu Ser Gln Glu Glu Leu His Cys Trp Lys Ile Trp Lys Gln Arg Ile 
65                  70                  75                  80  


Arg Asp Leu Ser Val Ser Gln Asp Tyr Ile Met Asn Leu Gln Glu Gln 
                85                  90                  95      


Cys Ser Pro His Leu Glu Asp Val Ser Leu Cys Glu Glu Trp Ala Gly 
            100                 105                 110         


Met Ser Leu Gln Ile Ser Glu Asn Glu Asn Tyr Val Val Asn Ala Ile 
        115                 120                 125             


Ile Lys Asn Gln Asp Ile Thr Ala Trp Gln Ser Leu Thr Gln Val Leu 
    130                 135                 140                 


Thr Pro Glu Ser Trp Arg Lys Ala Asn Ile Met Thr Glu Pro Gln Lys 
145                 150                 155                 160 


Ser Gln Gly Arg Tyr Lys Gly Ile Tyr Val Glu Glu Lys Leu Tyr Arg 
                165                 170                 175     


His Ala Arg His Asp Glu Ser Leu Asn Trp Thr Ser Arg Asp His His 
            180                 185                 190         


Glu Ser Gln Glu Cys Lys Gly Glu Asp Pro Gly Arg His Pro Asn Cys 
        195                 200                 205             


Gly Lys Asn Leu Gly Met Lys Ser Thr Val Glu Gln His His Ala Val 
    210                 215                 220                 


His Val Leu Pro Gln Pro Phe Thr Cys Asn Asn Cys Gly Val Ala Phe 
225                 230                 235                 240 


Ala Asp Asp Thr Asp Pro Arg Val His His Ser Thr His Leu Gly Glu 
                245                 250                 255     


Lys Ser Tyr Lys Cys Asp Gln Tyr Gly Lys Asn Leu Ser Gln Ser Gln 
            260                 265                 270         


Tyr Leu Ile Val His Cys Lys Thr His Ser Gly Glu Thr Pro Tyr Glu 
        275                 280                 285             


Phe His Glu Trp Pro Thr Gly Cys Lys Gln Ser Ser Asp Leu Pro Arg 
    290                 295                 300                 


Cys Gln Lys Val Pro Ser Gly Asp Asn Pro Tyr Lys Cys Lys Glu Cys 
305                 310                 315                 320 


Gly Lys Gly Phe Arg Cys Asn Ser Ser Leu His Asn His His Arg Val 
                325                 330                 335     


His Thr Gly Glu Met Pro Tyr Lys Cys His Val Cys Gly Lys Ala Phe 
            340                 345                 350         


Gly Phe Arg Ser Leu Pro Cys Ile His Gln Gly Val His Thr Gly Lys 
        355                 360                 365             


Lys Pro Tyr Lys Cys Glu Asp Cys Gly Lys Gly Phe Glu Gln Ser Ser 
    370                 375                 380                 


Asn Leu Leu Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys 
385                 390                 395                 400 


Ser Ser Glu Cys Gly Lys Cys Phe Ser Ser Ser Ser Val Leu Gln Val 
                405                 410                 415     


His Trp Arg Phe His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Glu Cys 
            420                 425                 430         


Gly Lys Gly Phe Ser Gln Ser Thr His Leu His Ile His Gln Arg Val 
        435                 440                 445             


His Thr Gly Glu Lys Gln Tyr Asn Ala Met Cys Val Glu Arg Ile Leu 
    450                 455                 460                 


Gly Ile Val Leu Phe Phe Thr Leu Ile Arg Glu Phe Thr Leu Gln Lys 
465                 470                 475                 480 


Asn His Ile Asn Ala Lys Cys Val Glu Ser Ala Leu Val Thr Val His 
                485                 490                 495     


Ile Phe Thr Ser Ile Lys Ala Ile Thr Gln Glu Arg Asn His Ile Asn 
            500                 505                 510         


Val Met Ser Val Val Lys Ala Ser Val Gly Ile Gln Ile Phe Asn Val 
        515                 520                 525             


His Leu Arg Val His Arg Gly Gln Arg Pro Cys Lys Cys Lys Ala Cys 
    530                 535                 540                 


Gly Lys Gly Phe Ser Arg Asn Ser His Leu Leu Ala Gln Gln Arg Val 
545                 550                 555                 560 


Arg Ile Asp Lys Thr Gln Tyr Thr His Cys Glu His Gly Lys Asp Leu 
                565                 570                 575     


Leu Thr His Gln Arg Leu His Glu Gln Arg Glu Thr Leu 
            580                 585                 


<210>  27
<211>  3285
<212>  DNA
<213>  Homo sapiens

<400>  27
atggcggccc gacaggccgt gggcagcggg gctcaggaga catgcggtct ggatcggatt       60

ttggaggcat tgaagctgct gctgagcccg ggaggctcgg gctcaagttc actacaggtc      120

acaaaacatg atgtcttgtt ggctacttta aaatctaacc tgtctgcttt ggaggacaag      180

tttctgaagg atcctcagtg gaagaatctg aaactcctaa gagatgaaat tgctgataag      240

gcagaatggc cacaaaactc tgtggatgtc acttggagtt ttacctctca aaccttgttg      300

ttgcttttgt gcttgaagga aaccatgatc cgccttgcag ctaatttcaa tccaggtaaa      360

cccaacccta ggactccgga agttgctcct gccctgagcc ccgatgcact tagtatctca      420

caacagaaga ctgtccagtt cgttttgcag tttgtagtta ccttgggtat ctgcccctat      480

ctcatgcctg gtgttggagt ccctttgaga tatagaactg aatttggtgc cgtcgttcaa      540

gacgtggtgt gttttgatgc tgcccccgat gcaactcgaa gactgtacac cagctgcaag      600

gcccttctga atgttgctca gcacacatct ctggggagct tgatcttctg ccaccacttt      660

ggggatatcg cagcaggtct gtgccaactg ggattctgcc caaccaaaag aaaactgcta      720

acacctgcag aagaggttct aactgaagag gagagaaccc tatccagggg ggccttgaga      780

gacatgctgg atcaagtcta tcagccctta gcagtccggg aactgcttat cctccaggga      840

ggaccacccc agtcctgcac agatgtgaag acacagatga ggtgtcgggc cccagcttgg      900

cttcggcgtc tatgtggaca gctgctctct gaaaggttaa tgagacctaa tggtgttcag      960

gcagtagtcc ggggcatttt ggaaggagca ggtgcgggag cagctggtgg aagtgatgct     1020

gaggtgacgg ctgctgactg gaagaagtgt gacctgatcg caaagatttt ggcctcttgt     1080

ccccagcagt ctctttcacc agagaattac tacagggaca tctgccccca ggttctggat     1140

ttatttcact ttcaagataa attgacagca cgacaatttc agagagttgc caccactacc     1200

tttataactt tgtcaagaga acgcccacat ttggcagcaa agtatttgct ccagccagtg     1260

ttagctcctc ttcatcgatg tttgaataca gcagagcttt cagagagtga catggtacca     1320

ggaactattt tggtgacaga agaagaactt agtagatgca ttgaggatgt gtttaaggtg     1380

tacgtggttg ggaatgaacc tttaacagtt ttgatggatt ccctgcttcc agtcctggga     1440

gtgctttttc ttctctactg ttttactaag cagagtgtgt ctcacataag gtcactttgc     1500

caagaaatct tattatggat tctggggaag ctggaaagga agaaggcaat tgccagcctg     1560

aaaggatttg cagggttgga caaagctgtg ccctctctcc attctctgtg tcagtttaga     1620

gttgccactc aaggtggcat tatgattacc atcaaagagg ccattagtga tgaagatgaa     1680

gatgaagccc tgtaccagaa ggtatcctct gagcagggcc gggtggagca tctcggggac     1740

ttgctgtccc actgccagga atgcggtttg gcaggagact tcttcatctt ctgtttgaaa     1800

gagttgactc atgtggcctc ggaaaatgaa acagagttaa aaactgagcc cttctccagc     1860

aagagcctct tggaattaga gcaacatcag actcttcttg tggaaggcca agagcggaag     1920

ctgcttgtcc tgcagctgat ggctgttctg tgcgagagaa tgtctgagca gatattcaca     1980

aacgtcactc aggtggtgga ctttgtagca gcaacattgc agagagcctg tgcaagcctg     2040

gcccatcagg cagagagcac cgtggaatca cagacgctga gcatgtccat ggggctggtg     2100

gctgtcatgc taggaggagc tgttcagttg aagtcaagtg attttgctgt tctgaagcag     2160

ttgttgcctc tgttggagaa ggtatccaac acataccctg atccggtcat ccaagaactc     2220

gctgttgatc tccgcatcac catctctacc catggagcct ttgccactga ggccgtcagc     2280

atggctgccc aaagtacact gaacagaaaa gatctggaag ggaaaataga agagcagcaa     2340

caaaccagtc atgaaagacc cactgatgta gctcatagcc accttgaaca acagcagagc     2400

catgagacag ccccccagac aggcctgcag tcaaatgctc caatcattcc tcaaggagtc     2460

aatgagccca gcactactac aagtcagaaa tctggaagcg taaccacaga acagctccaa     2520

gaggttcttt tgtcagctta tgaccctcaa attccaacac gggctgctgc cctgcgtact     2580

ctttcccact ggatagagca gagagaagca aaagcccttg agatgcaaga gaagcttctc     2640

aagatattct tggaaaactt ggaacatgaa gacacttttg tatatctatc tgcaattcag     2700

ggggttgccc tgctgtcaga cgtctatcct gagaaaatct tgccggactt gttggctcaa     2760

tatgacagca gcaaagacaa gcacacacca gagaccagaa tgaaagtcgg ggaagtcctt     2820

atgcgaatcg tcagggcatt aggagacatg gtctcaaagt accgagaacc tttgatccat     2880

accttcctga ggggagtgag agatcctgat ggtgctcaca gggccagcag cttggccaac     2940

cttggggagc tgtgccagag gctggacttt ctgctgggct ccgtggtcca tgaggtaaca     3000

gcttgcctga ttgctgtggc caaaacagat ggtgaagttc aagtacgcag agctgccata     3060

catgtggttg tgctgctgct tcggggactc agccagaaag ctactgaggt gctgagcgcc     3120

gtcctcaagg atctctacca cctgctgaag cacgtagtgt gtctggagcc cgatgacgtg     3180

gccaagctcc atgcccagtt ggccctagaa gagctggatg acatcatgaa aaacttcctg     3240

ttccctccac agaagctgga gaagaagatc atggtcctgc cgtag                     3285


<210>  28
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ala Arg Gln Ala Val Gly Ser Gly Ala Gln Glu Thr Cys Gly 
1               5                   10                  15      


Leu Asp Arg Ile Leu Glu Ala Leu Lys Leu Leu Leu Ser Pro Gly Gly 
            20                  25                  30          


Ser Gly Ser Ser Ser Leu Gln Val Thr Lys His Asp Val Leu Leu Ala 
        35                  40                  45              


Thr Leu Lys Ser Asn Leu Ser Ala Leu Glu Asp Lys Phe Leu Lys Asp 
    50                  55                  60                  


Pro Gln Trp Lys Asn Leu Lys Leu Leu Arg Asp Glu Ile Ala Asp Lys 
65                  70                  75                  80  


Ala Glu Trp Pro Gln Asn Ser Val Asp Val Thr Trp Ser Phe Thr Ser 
                85                  90                  95      


Gln Thr Leu Leu Leu Leu Leu Cys Leu Lys Glu Thr Met Ile Arg Leu 
            100                 105                 110         


Ala Ala Asn Phe Asn Pro Gly Lys Pro Asn Pro Arg Thr Pro Glu Val 
        115                 120                 125             


Ala Pro Ala Leu Ser Pro Asp Ala Leu Ser Ile Ser Gln Gln Lys Thr 
    130                 135                 140                 


Val Gln Phe Val Leu Gln Phe Val Val Thr Leu Gly Ile Cys Pro Tyr 
145                 150                 155                 160 


Leu Met Pro Gly Val Gly Val Pro Leu Arg Tyr Arg Thr Glu Phe Gly 
                165                 170                 175     


Ala Val Val Gln Asp Val Val Cys Phe Asp Ala Ala Pro Asp Ala Thr 
            180                 185                 190         


Arg Arg Leu Tyr Thr Ser Cys Lys Ala Leu Leu Asn Val Ala Gln His 
        195                 200                 205             


Thr Ser Leu Gly Ser Leu Ile Phe Cys His His Phe Gly Asp Ile Ala 
    210                 215                 220                 


Ala Gly Leu Cys Gln Leu Gly Phe Cys Pro Thr Lys Arg Lys Leu Leu 
225                 230                 235                 240 


Thr Pro Ala Glu Glu Val Leu Thr Glu Glu Glu Arg Thr Leu Ser Arg 
                245                 250                 255     


Gly Ala Leu Arg Asp Met Leu Asp Gln Val Tyr Gln Pro Leu Ala Val 
            260                 265                 270         


Arg Glu Leu Leu Ile Leu Gln Gly Gly Pro Pro Gln Ser Cys Thr Asp 
        275                 280                 285             


Val Lys Thr Gln Met Arg Cys Arg Ala Pro Ala Trp Leu Arg Arg Leu 
    290                 295                 300                 


Cys Gly Gln Leu Leu Ser Glu Arg Leu Met Arg Pro Asn Gly Val Gln 
305                 310                 315                 320 


Ala Val Val Arg Gly Ile Leu Glu Gly Ala Gly Ala Gly Ala Ala Gly 
                325                 330                 335     


Gly Ser Asp Ala Glu Val Thr Ala Ala Asp Trp Lys Lys Cys Asp Leu 
            340                 345                 350         


Ile Ala Lys Ile Leu Ala Ser Cys Pro Gln Gln Ser Leu Ser Pro Glu 
        355                 360                 365             


Asn Tyr Tyr Arg Asp Ile Cys Pro Gln Val Leu Asp Leu Phe His Phe 
    370                 375                 380                 


Gln Asp Lys Leu Thr Ala Arg Gln Phe Gln Arg Val Ala Thr Thr Thr 
385                 390                 395                 400 


Phe Ile Thr Leu Ser Arg Glu Arg Pro His Leu Ala Ala Lys Tyr Leu 
                405                 410                 415     


Leu Gln Pro Val Leu Ala Pro Leu His Arg Cys Leu Asn Thr Ala Glu 
            420                 425                 430         


Leu Ser Glu Ser Asp Met Val Pro Gly Thr Ile Leu Val Thr Glu Glu 
        435                 440                 445             


Glu Leu Ser Arg Cys Ile Glu Asp Val Phe Lys Val Tyr Val Val Gly 
    450                 455                 460                 


Asn Glu Pro Leu Thr Val Leu Met Asp Ser Leu Leu Pro Val Leu Gly 
465                 470                 475                 480 


Val Leu Phe Leu Leu Tyr Cys Phe Thr Lys Gln Ser Val Ser His Ile 
                485                 490                 495     


Arg Ser Leu Cys Gln Glu Ile Leu Leu Trp Ile Leu Gly Lys Leu Glu 
            500                 505                 510         


Arg Lys Lys Ala Ile Ala Ser Leu Lys Gly Phe Ala Gly Leu Asp Lys 
        515                 520                 525             


Ala Val Pro Ser Leu His Ser Leu Cys Gln Phe Arg Val Ala Thr Gln 
    530                 535                 540                 


Gly Gly Ile Met Ile Thr Ile Lys Glu Ala Ile Ser Asp Glu Asp Glu 
545                 550                 555                 560 


Asp Glu Ala Leu Tyr Gln Lys Val Ser Ser Glu Gln Gly Arg Val Glu 
                565                 570                 575     


His Leu Gly Asp Leu Leu Ser His Cys Gln Glu Cys Gly Leu Ala Gly 
            580                 585                 590         


Asp Phe Phe Ile Phe Cys Leu Lys Glu Leu Thr His Val Ala Ser Glu 
        595                 600                 605             


Asn Glu Thr Glu Leu Lys Thr Glu Pro Phe Ser Ser Lys Ser Leu Leu 
    610                 615                 620                 


Glu Leu Glu Gln His Gln Thr Leu Leu Val Glu Gly Gln Glu Arg Lys 
625                 630                 635                 640 


Leu Leu Val Leu Gln Leu Met Ala Val Leu Cys Glu Arg Met Ser Glu 
                645                 650                 655     


Gln Ile Phe Thr Asn Val Thr Gln Val Val Asp Phe Val Ala Ala Thr 
            660                 665                 670         


Leu Gln Arg Ala Cys Ala Ser Leu Ala His Gln Ala Glu Ser Thr Val 
        675                 680                 685             


Glu Ser Gln Thr Leu Ser Met Ser Met Gly Leu Val Ala Val Met Leu 
    690                 695                 700                 


Gly Gly Ala Val Gln Leu Lys Ser Ser Asp Phe Ala Val Leu Lys Gln 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Glu Lys Val Ser Asn Thr Tyr Pro Asp Pro Val 
                725                 730                 735     


Ile Gln Glu Leu Ala Val Asp Leu Arg Ile Thr Ile Ser Thr His Gly 
            740                 745                 750         


Ala Phe Ala Thr Glu Ala Val Ser Met Ala Ala Gln Ser Thr Leu Asn 
        755                 760                 765             


Arg Lys Asp Leu Glu Gly Lys Ile Glu Glu Gln Gln Gln Thr Ser His 
    770                 775                 780                 


Glu Arg Pro Thr Asp Val Ala His Ser His Leu Glu Gln Gln Gln Ser 
785                 790                 795                 800 


His Glu Thr Ala Pro Gln Thr Gly Leu Gln Ser Asn Ala Pro Ile Ile 
                805                 810                 815     


Pro Gln Gly Val Asn Glu Pro Ser Thr Thr Thr Ser Gln Lys Ser Gly 
            820                 825                 830         


Ser Val Thr Thr Glu Gln Leu Gln Glu Val Leu Leu Ser Ala Tyr Asp 
        835                 840                 845             


Pro Gln Ile Pro Thr Arg Ala Ala Ala Leu Arg Thr Leu Ser His Trp 
    850                 855                 860                 


Ile Glu Gln Arg Glu Ala Lys Ala Leu Glu Met Gln Glu Lys Leu Leu 
865                 870                 875                 880 


Lys Ile Phe Leu Glu Asn Leu Glu His Glu Asp Thr Phe Val Tyr Leu 
                885                 890                 895     


Ser Ala Ile Gln Gly Val Ala Leu Leu Ser Asp Val Tyr Pro Glu Lys 
            900                 905                 910         


Ile Leu Pro Asp Leu Leu Ala Gln Tyr Asp Ser Ser Lys Asp Lys His 
        915                 920                 925             


Thr Pro Glu Thr Arg Met Lys Val Gly Glu Val Leu Met Arg Ile Val 
    930                 935                 940                 


Arg Ala Leu Gly Asp Met Val Ser Lys Tyr Arg Glu Pro Leu Ile His 
945                 950                 955                 960 


Thr Phe Leu Arg Gly Val Arg Asp Pro Asp Gly Ala His Arg Ala Ser 
                965                 970                 975     


Ser Leu Ala Asn Leu Gly Glu Leu Cys Gln Arg Leu Asp Phe Leu Leu 
            980                 985                 990         


Gly Ser Val Val His Glu Val Thr  Ala Cys Leu Ile Ala  Val Ala Lys 
        995                 1000                 1005             


Thr Asp  Gly Glu Val Gln Val  Arg Arg Ala Ala Ile  His Val Val 
    1010                 1015                 1020             


Val Leu  Leu Leu Arg Gly Leu  Ser Gln Lys Ala Thr  Glu Val Leu 
    1025                 1030                 1035             


Ser Ala  Val Leu Lys Asp Leu  Tyr His Leu Leu Lys  His Val Val 
    1040                 1045                 1050             


Cys Leu  Glu Pro Asp Asp Val  Ala Lys Leu His Ala  Gln Leu Ala 
    1055                 1060                 1065             


Leu Glu  Glu Leu Asp Asp Ile  Met Lys Asn Phe Leu  Phe Pro Pro 
    1070                 1075                 1080             


Gln Lys  Leu Glu Lys Lys Ile  Met Val Leu Pro 
    1085                 1090                 


<210>  29
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  29
atgttcgtgc aggaggagaa gatcttcgcg ggcaaggtgc tgcggctgca catctgcgcg       60

tccgacggcg ccgagtggct ggaggaggcc accgaggaca cctcggtgga gaagctcaag      120

gagcgctgcc tcaagcactg tgctcatggg agcttagaag atcccaaaag tataacccat      180

cataaattaa tccacgctgc ctcagagagg gtgctgagtg atgccaggac catcctggaa      240

gagaacatcc aggaccaaga tgtcctatta ttgataaaaa agcgtgctcc atcaccactt      300

cccaagatgg ctgatgtctc agcagaagaa aagaaaaaac aagaccagaa agctccagat      360

aaagaggcca tactgcgggc caccgccaac ctgccctcct acaacatgga ccgggccgcg      420

gtccagacca acatgagaga cttccagaca gaactccgga agatactggt gtctctcatc      480

gaggtggcgc agaagctgtt agcgctgaac ccagatgcag tggaattgtt taagaaggcg      540

aatgcaatgc tggacgagga cgaggatgag cgtgtggacg aggctgccct gcggcagctc      600

acggagatgg gctttccgga gaacagagcc accaaggccc ttcagctgaa ccacatgtcg      660

gtgcctcagg ccatggagtg gctaattgaa cacgcagaag acccgaccat agacacgcct      720

cttcctggcc aagctccccc agaggccgag ggggccacag cagctgcctc cgaggctgcc      780

gcgggagcca gcgccaccga tgaggaggcc agagatgagc tgacggaaat cttcaagaag      840

atccggagga aaagggagtt tcgggctgat gctcgggccg tcatttccct gatggagatg      900

gggttcgacg agaaagaggt gatagatgcc ctcagagtga acaacaacca gcagaatgcc      960

gcgtgcgagt ggctgctggg ggaccggaag ccctctccgg aggagctgga caagggcatc     1020

gaccccgaca gtcctctctt tcaggccatc ctggataacc cggtggtgca gctgggcctg     1080

accaacccga aaacattgct agcatttgaa gacatgctgg agaacccact gaacagcacc     1140

cagtggatga atgatccaga aacggggcct gtcatgctgc agatctctag aatcttccag     1200

acactaaatc gcacgtag                                                   1218


<210>  30
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Phe Val Gln Glu Glu Lys Ile Phe Ala Gly Lys Val Leu Arg Leu 
1               5                   10                  15      


His Ile Cys Ala Ser Asp Gly Ala Glu Trp Leu Glu Glu Ala Thr Glu 
            20                  25                  30          


Asp Thr Ser Val Glu Lys Leu Lys Glu Arg Cys Leu Lys His Cys Ala 
        35                  40                  45              


His Gly Ser Leu Glu Asp Pro Lys Ser Ile Thr His His Lys Leu Ile 
    50                  55                  60                  


His Ala Ala Ser Glu Arg Val Leu Ser Asp Ala Arg Thr Ile Leu Glu 
65                  70                  75                  80  


Glu Asn Ile Gln Asp Gln Asp Val Leu Leu Leu Ile Lys Lys Arg Ala 
                85                  90                  95      


Pro Ser Pro Leu Pro Lys Met Ala Asp Val Ser Ala Glu Glu Lys Lys 
            100                 105                 110         


Lys Gln Asp Gln Lys Ala Pro Asp Lys Glu Ala Ile Leu Arg Ala Thr 
        115                 120                 125             


Ala Asn Leu Pro Ser Tyr Asn Met Asp Arg Ala Ala Val Gln Thr Asn 
    130                 135                 140                 


Met Arg Asp Phe Gln Thr Glu Leu Arg Lys Ile Leu Val Ser Leu Ile 
145                 150                 155                 160 


Glu Val Ala Gln Lys Leu Leu Ala Leu Asn Pro Asp Ala Val Glu Leu 
                165                 170                 175     


Phe Lys Lys Ala Asn Ala Met Leu Asp Glu Asp Glu Asp Glu Arg Val 
            180                 185                 190         


Asp Glu Ala Ala Leu Arg Gln Leu Thr Glu Met Gly Phe Pro Glu Asn 
        195                 200                 205             


Arg Ala Thr Lys Ala Leu Gln Leu Asn His Met Ser Val Pro Gln Ala 
    210                 215                 220                 


Met Glu Trp Leu Ile Glu His Ala Glu Asp Pro Thr Ile Asp Thr Pro 
225                 230                 235                 240 


Leu Pro Gly Gln Ala Pro Pro Glu Ala Glu Gly Ala Thr Ala Ala Ala 
                245                 250                 255     


Ser Glu Ala Ala Ala Gly Ala Ser Ala Thr Asp Glu Glu Ala Arg Asp 
            260                 265                 270         


Glu Leu Thr Glu Ile Phe Lys Lys Ile Arg Arg Lys Arg Glu Phe Arg 
        275                 280                 285             


Ala Asp Ala Arg Ala Val Ile Ser Leu Met Glu Met Gly Phe Asp Glu 
    290                 295                 300                 


Lys Glu Val Ile Asp Ala Leu Arg Val Asn Asn Asn Gln Gln Asn Ala 
305                 310                 315                 320 


Ala Cys Glu Trp Leu Leu Gly Asp Arg Lys Pro Ser Pro Glu Glu Leu 
                325                 330                 335     


Asp Lys Gly Ile Asp Pro Asp Ser Pro Leu Phe Gln Ala Ile Leu Asp 
            340                 345                 350         


Asn Pro Val Val Gln Leu Gly Leu Thr Asn Pro Lys Thr Leu Leu Ala 
        355                 360                 365             


Phe Glu Asp Met Leu Glu Asn Pro Leu Asn Ser Thr Gln Trp Met Asn 
    370                 375                 380                 


Asp Pro Glu Thr Gly Pro Val Met Leu Gln Ile Ser Arg Ile Phe Gln 
385                 390                 395                 400 


Thr Leu Asn Arg Thr 
                405 


<210>  31
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  31
atgacctcca agaagctggt gaactcggtg gctggctgtg ctgatgacgc tcttgctggc       60

ctggtggcct gcaaccccaa cctgcagctc ctgcagggcc accgcgtggc cctccgttct      120

gacctggaca gcctcaaggg ccgggtggca ctgctgtcgg gtgggggctc tggccatgag      180

cctgcccatg ctggtttcat agggaagggg atgctgactg gggtcatcgc gggagctgtg      240

ttcacctccc cggcagtggg cagcatcctg gcagccatca gggccgtggc ccaggccggc      300

acagtgggga cgctccttat cgtgaagaac tacactgggg atcggctcaa cttcggcctg      360

gcccgggagc aggcccgggc tgaaggcatc ccggtggaga tggtggtgat tggggacgac      420

agcgccttca ctgtcctgaa gaaggcaggc cggcgggggc tgtgcggcac ggtgcttata      480

cacaaggtgg caggtgctct ggctgaggct ggtgtggggc tggaggagat cgcaaagcag      540

gtgaacgtgg tcgccaaggc catgggtacc ctgggggtga gcttatcctc ctgcagcgtc      600

cctggttcca aacccacctt cgagctctca gccgacgagg tggagctggg cctggggatc      660

cacggggaag ctggtgtgcg ccggataaag atggcaaccg ccgatgagat tgtgaaactc      720

atgctcgacc acatgacaaa caccaccaac gcgtcccatg tgcctgtgca gcccggctcc      780

tcagttgtga tgatggtcaa caacctgggt ggcctgtcat tcctggaact gggcatcata      840

gccgacgcta ccgtccgctc cctggagggc cgcggggtga agattgcccg tgccctggtg      900

ggcaccttca tgtcagcact ggagatgcct ggcatttctc tcaccctcct gctggtggat      960

gagcctctcc tgaaactgat agatgctgaa accactgcag cagcctggcc taacgtggct     1020

gcagtctcca ttactgggcg gaagcggagc cgggtagccc ctgccgagcc ccaggaggcc     1080

cctgattcca ctgctgcagg aggctcagcc tcgaagcgga tggcgctggt gctggaacgg     1140

gtgtgcagca ctctcctggg cctggaggaa cacctgaatg ccctggaccg ggctgctggt     1200

gacggcgact gtggcaccac ccacagccgt gcggccagag caatccagga gtggctgaag     1260

gagggcccac cccctgccag ccctgcccag ctgctctcca agttgtctgt cctgctcctg     1320

gagaagatgg gaggctcatc tggggcgctc tatggcctgt tcctgactgc ggctgcacag     1380

cccctgaagg ccaagaccag cctcccagcc tggtctgctg ccatggatgc cggcctggaa     1440

gccatgcaga agtatggcaa ggctgctcca ggggacagga ctatgctgga ttctctgtgg     1500

gcagcggggc aggagctcca agcctggaag agcccaggag ctgatctgtt acaagtcctg     1560

accaaagcag tcaagagtgc cgaagctgca gccgaggcca ccaagaatat ggaagctgga     1620

gccggaagag ccagttatat cagctcagca cggctggagc agccagaccc cggggcggtg     1680

gcagctgctg ccatcctccg ggccatcttg gaggtcttgc agagctag                  1728


<210>  32
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp 
1               5                   10                  15      


Ala Leu Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln 
            20                  25                  30          


Gly His Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg 
        35                  40                  45              


Val Ala Leu Leu Ser Gly Gly Gly Ser Gly His Glu Pro Ala His Ala 
    50                  55                  60                  


Gly Phe Ile Gly Lys Gly Met Leu Thr Gly Val Ile Ala Gly Ala Val 
65                  70                  75                  80  


Phe Thr Ser Pro Ala Val Gly Ser Ile Leu Ala Ala Ile Arg Ala Val 
                85                  90                  95      


Ala Gln Ala Gly Thr Val Gly Thr Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Arg Glu Gln Ala Arg Ala Glu 
        115                 120                 125             


Gly Ile Pro Val Glu Met Val Val Ile Gly Asp Asp Ser Ala Phe Thr 
    130                 135                 140                 


Val Leu Lys Lys Ala Gly Arg Arg Gly Leu Cys Gly Thr Val Leu Ile 
145                 150                 155                 160 


His Lys Val Ala Gly Ala Leu Ala Glu Ala Gly Val Gly Leu Glu Glu 
                165                 170                 175     


Ile Ala Lys Gln Val Asn Val Val Ala Lys Ala Met Gly Thr Leu Gly 
            180                 185                 190         


Val Ser Leu Ser Ser Cys Ser Val Pro Gly Ser Lys Pro Thr Phe Glu 
        195                 200                 205             


Leu Ser Ala Asp Glu Val Glu Leu Gly Leu Gly Ile His Gly Glu Ala 
    210                 215                 220                 


Gly Val Arg Arg Ile Lys Met Ala Thr Ala Asp Glu Ile Val Lys Leu 
225                 230                 235                 240 


Met Leu Asp His Met Thr Asn Thr Thr Asn Ala Ser His Val Pro Val 
                245                 250                 255     


Gln Pro Gly Ser Ser Val Val Met Met Val Asn Asn Leu Gly Gly Leu 
            260                 265                 270         


Ser Phe Leu Glu Leu Gly Ile Ile Ala Asp Ala Thr Val Arg Ser Leu 
        275                 280                 285             


Glu Gly Arg Gly Val Lys Ile Ala Arg Ala Leu Val Gly Thr Phe Met 
    290                 295                 300                 


Ser Ala Leu Glu Met Pro Gly Ile Ser Leu Thr Leu Leu Leu Val Asp 
305                 310                 315                 320 


Glu Pro Leu Leu Lys Leu Ile Asp Ala Glu Thr Thr Ala Ala Ala Trp 
                325                 330                 335     


Pro Asn Val Ala Ala Val Ser Ile Thr Gly Arg Lys Arg Ser Arg Val 
            340                 345                 350         


Ala Pro Ala Glu Pro Gln Glu Ala Pro Asp Ser Thr Ala Ala Gly Gly 
        355                 360                 365             


Ser Ala Ser Lys Arg Met Ala Leu Val Leu Glu Arg Val Cys Ser Thr 
    370                 375                 380                 


Leu Leu Gly Leu Glu Glu His Leu Asn Ala Leu Asp Arg Ala Ala Gly 
385                 390                 395                 400 


Asp Gly Asp Cys Gly Thr Thr His Ser Arg Ala Ala Arg Ala Ile Gln 
                405                 410                 415     


Glu Trp Leu Lys Glu Gly Pro Pro Pro Ala Ser Pro Ala Gln Leu Leu 
            420                 425                 430         


Ser Lys Leu Ser Val Leu Leu Leu Glu Lys Met Gly Gly Ser Ser Gly 
        435                 440                 445             


Ala Leu Tyr Gly Leu Phe Leu Thr Ala Ala Ala Gln Pro Leu Lys Ala 
    450                 455                 460                 


Lys Thr Ser Leu Pro Ala Trp Ser Ala Ala Met Asp Ala Gly Leu Glu 
465                 470                 475                 480 


Ala Met Gln Lys Tyr Gly Lys Ala Ala Pro Gly Asp Arg Thr Met Leu 
                485                 490                 495     


Asp Ser Leu Trp Ala Ala Gly Gln Glu Leu Gln Ala Trp Lys Ser Pro 
            500                 505                 510         


Gly Ala Asp Leu Leu Gln Val Leu Thr Lys Ala Val Lys Ser Ala Glu 
        515                 520                 525             


Ala Ala Ala Glu Ala Thr Lys Asn Met Glu Ala Gly Ala Gly Arg Ala 
    530                 535                 540                 


Ser Tyr Ile Ser Ser Ala Arg Leu Glu Gln Pro Asp Pro Gly Ala Val 
545                 550                 555                 560 


Ala Ala Ala Ala Ile Leu Arg Ala Ile Leu Glu Val Leu Gln Ser 
                565                 570                 575 


<210>  33
<211>  2376
<212>  DNA
<213>  Homo sapiens

<400>  33
atgtggaata tgctcatagt ggcgatgtgc ttggcccttc tgggctgcct gcaagcccag       60

gagctccagg gacatgtctc cataatcctg ctgggagcaa ctggggacct ggctaagaag      120

tacttatggc agggactgtt ccagctgtac ctggatgaag cggggagggg tcacagtttt      180

agcttccatg gagctgctct gacagccccc aagcagggtc aagagctcat ggccaaggcc      240

ctggaatccc tctcctgccc caaggacatg gcacccagtc actgtgcaga gcacaaggat      300

cagttcctgc agctgagcca gtaccgccaa ctgaagacgg ccgaggacta tcaggccctg      360

aacaaggaca tcgaggcaca gctccagcac gcaggcctcc gggaggctgg caggatcttc      420

tacttctcag tgccaccctt cgcctatgaa gacattgccc gcaacatcaa cagtagctgc      480

cggccaggcc cgggcgcctg gctgcgggtt gtccttgaga aaccctttgg ccatgaccac      540

ttctcagccc agcagctggc cacagaactc gggacctttt tccaggagga ggagatgtac      600

cgggtggacc attacttagg caagcaggct gtggcgcaga tcctgccttt ccgagaccag      660

aaccgcaagg ctttggacgg cctctggaac cggcaccatg tggagcgggt ggagatcatc      720

atgaaagaga ccgtggatgc tgaaggccgc accagcttct atgaggagta cggtgtcatt      780

cgcgacgtcc tccagaacca tctgacggag gtcctcaccc tcgtggccat ggagctgccc      840

cacaatgtca gcagtgcgga ggctgtgctg cggcacaagc ttcaggtctt ccaggcgctg      900

cggggcctgc agaggggcag tgccgtcgtg ggccagtacc agtcttacag tgagcaggtg      960

cgcagagagc tgcagaagcc agacagcttc cacagcctga cgccgacctt cgcagccgtc     1020

ctagtgcaca ttgacaacct tcgctgggag ggcgtgcctt tcatcctgat gtctggcaaa     1080

gccttggacg agagagtggg ctacgctcgg atcttgttca agaaccaggc ctgctgtgtg     1140

cagagcgaaa agcactgggc cgcggcgcag agccagtgcc tgccccggca gctcgtcttc     1200

cacatcggcc atggcgacct gggcagccct gccgtgctgg tcagcaggaa cctgttcagg     1260

ccctccctgc cctccagctg gaaggaaatg gagggaccac ctgggctccg ccttttcggc     1320

agccctctgt ccgattacta cgcctacagc cctgtgcggg agcgggacgc ccactccgtc     1380

ctcttatccc atatcttcca tggccggaag aatttcttca tcaccacaga gaacttgctg     1440

gcctcctgga acttctggac ccctctgctg gagagcctgg cccataaggc cccacgcctc     1500

taccctggag gagctgagaa tggccgtctg ttggactttg agttcagtag cggccggttg     1560

ttcttttccc agcagcagcc ggagcagctg gtgccagggc cagggccggc cccaatgccc     1620

agtgacttcc aggtcctcag ggccaagtac cgagagagcc cgctggtctc cgcctggtcc     1680

gaggagctga tctctaagct ggctaatgac atcgaggcca ccgctgtgcg agccgtgcgg     1740

cgctttggcc agttccacct ggcactgtcg gggggctcga gccccgtggc cctgttccag     1800

cagctggcca cggcgcacta tggcttcccc tgggcccaca cgcacctgtg gctggttgac     1860

gagcgctgcg tcccactctc agacccggag tccaacttcc agggcctgca ggcccacctg     1920

ctgcagcacg tccggatccc ctactacaac atccacccca tgcctgtgca cctgcagcag     1980

cggctctgcg ccgaggagga ccagggcgcc cagatctatg ccagggagat ctcagccctg     2040

gtggccaaca gcagcttcga cctggtgctg ctgggcatgg gtgccgacgg gcacacagcc     2100

tccctcttcc cacagtcacc cactggcctg gatggcgagc agctggtcgt gctgaccacg     2160

agcccctccc agccacaccg ccgcatgagc cttagcctgc ctctcatcaa ccgcgccaag     2220

aaggtggcag tcctggtcat gggcaggatg aagcgtgaga tcaccacgct ggtgagccgg     2280

gtgggccatg agcccaagaa gtggcccatc tcgggtgtcc tgccgcactc cggccagctg     2340

gtgtggtaca tggactacga cgccttcctg ggatga                               2376


<210>  34
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Trp Asn Met Leu Ile Val Ala Met Cys Leu Ala Leu Leu Gly Cys 
1               5                   10                  15      


Leu Gln Ala Gln Glu Leu Gln Gly His Val Ser Ile Ile Leu Leu Gly 
            20                  25                  30          


Ala Thr Gly Asp Leu Ala Lys Lys Tyr Leu Trp Gln Gly Leu Phe Gln 
        35                  40                  45              


Leu Tyr Leu Asp Glu Ala Gly Arg Gly His Ser Phe Ser Phe His Gly 
    50                  55                  60                  


Ala Ala Leu Thr Ala Pro Lys Gln Gly Gln Glu Leu Met Ala Lys Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ser Cys Pro Lys Asp Met Ala Pro Ser His Cys Ala 
                85                  90                  95      


Glu His Lys Asp Gln Phe Leu Gln Leu Ser Gln Tyr Arg Gln Leu Lys 
            100                 105                 110         


Thr Ala Glu Asp Tyr Gln Ala Leu Asn Lys Asp Ile Glu Ala Gln Leu 
        115                 120                 125             


Gln His Ala Gly Leu Arg Glu Ala Gly Arg Ile Phe Tyr Phe Ser Val 
    130                 135                 140                 


Pro Pro Phe Ala Tyr Glu Asp Ile Ala Arg Asn Ile Asn Ser Ser Cys 
145                 150                 155                 160 


Arg Pro Gly Pro Gly Ala Trp Leu Arg Val Val Leu Glu Lys Pro Phe 
                165                 170                 175     


Gly His Asp His Phe Ser Ala Gln Gln Leu Ala Thr Glu Leu Gly Thr 
            180                 185                 190         


Phe Phe Gln Glu Glu Glu Met Tyr Arg Val Asp His Tyr Leu Gly Lys 
        195                 200                 205             


Gln Ala Val Ala Gln Ile Leu Pro Phe Arg Asp Gln Asn Arg Lys Ala 
    210                 215                 220                 


Leu Asp Gly Leu Trp Asn Arg His His Val Glu Arg Val Glu Ile Ile 
225                 230                 235                 240 


Met Lys Glu Thr Val Asp Ala Glu Gly Arg Thr Ser Phe Tyr Glu Glu 
                245                 250                 255     


Tyr Gly Val Ile Arg Asp Val Leu Gln Asn His Leu Thr Glu Val Leu 
            260                 265                 270         


Thr Leu Val Ala Met Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala 
        275                 280                 285             


Val Leu Arg His Lys Leu Gln Val Phe Gln Ala Leu Arg Gly Leu Gln 
    290                 295                 300                 


Arg Gly Ser Ala Val Val Gly Gln Tyr Gln Ser Tyr Ser Glu Gln Val 
305                 310                 315                 320 


Arg Arg Glu Leu Gln Lys Pro Asp Ser Phe His Ser Leu Thr Pro Thr 
                325                 330                 335     


Phe Ala Ala Val Leu Val His Ile Asp Asn Leu Arg Trp Glu Gly Val 
            340                 345                 350         


Pro Phe Ile Leu Met Ser Gly Lys Ala Leu Asp Glu Arg Val Gly Tyr 
        355                 360                 365             


Ala Arg Ile Leu Phe Lys Asn Gln Ala Cys Cys Val Gln Ser Glu Lys 
    370                 375                 380                 


His Trp Ala Ala Ala Gln Ser Gln Cys Leu Pro Arg Gln Leu Val Phe 
385                 390                 395                 400 


His Ile Gly His Gly Asp Leu Gly Ser Pro Ala Val Leu Val Ser Arg 
                405                 410                 415     


Asn Leu Phe Arg Pro Ser Leu Pro Ser Ser Trp Lys Glu Met Glu Gly 
            420                 425                 430         


Pro Pro Gly Leu Arg Leu Phe Gly Ser Pro Leu Ser Asp Tyr Tyr Ala 
        435                 440                 445             


Tyr Ser Pro Val Arg Glu Arg Asp Ala His Ser Val Leu Leu Ser His 
    450                 455                 460                 


Ile Phe His Gly Arg Lys Asn Phe Phe Ile Thr Thr Glu Asn Leu Leu 
465                 470                 475                 480 


Ala Ser Trp Asn Phe Trp Thr Pro Leu Leu Glu Ser Leu Ala His Lys 
                485                 490                 495     


Ala Pro Arg Leu Tyr Pro Gly Gly Ala Glu Asn Gly Arg Leu Leu Asp 
            500                 505                 510         


Phe Glu Phe Ser Ser Gly Arg Leu Phe Phe Ser Gln Gln Gln Pro Glu 
        515                 520                 525             


Gln Leu Val Pro Gly Pro Gly Pro Ala Pro Met Pro Ser Asp Phe Gln 
    530                 535                 540                 


Val Leu Arg Ala Lys Tyr Arg Glu Ser Pro Leu Val Ser Ala Trp Ser 
545                 550                 555                 560 


Glu Glu Leu Ile Ser Lys Leu Ala Asn Asp Ile Glu Ala Thr Ala Val 
                565                 570                 575     


Arg Ala Val Arg Arg Phe Gly Gln Phe His Leu Ala Leu Ser Gly Gly 
            580                 585                 590         


Ser Ser Pro Val Ala Leu Phe Gln Gln Leu Ala Thr Ala His Tyr Gly 
        595                 600                 605             


Phe Pro Trp Ala His Thr His Leu Trp Leu Val Asp Glu Arg Cys Val 
    610                 615                 620                 


Pro Leu Ser Asp Pro Glu Ser Asn Phe Gln Gly Leu Gln Ala His Leu 
625                 630                 635                 640 


Leu Gln His Val Arg Ile Pro Tyr Tyr Asn Ile His Pro Met Pro Val 
                645                 650                 655     


His Leu Gln Gln Arg Leu Cys Ala Glu Glu Asp Gln Gly Ala Gln Ile 
            660                 665                 670         


Tyr Ala Arg Glu Ile Ser Ala Leu Val Ala Asn Ser Ser Phe Asp Leu 
        675                 680                 685             


Val Leu Leu Gly Met Gly Ala Asp Gly His Thr Ala Ser Leu Phe Pro 
    690                 695                 700                 


Gln Ser Pro Thr Gly Leu Asp Gly Glu Gln Leu Val Val Leu Thr Thr 
705                 710                 715                 720 


Ser Pro Ser Gln Pro His Arg Arg Met Ser Leu Ser Leu Pro Leu Ile 
                725                 730                 735     


Asn Arg Ala Lys Lys Val Ala Val Leu Val Met Gly Arg Met Lys Arg 
            740                 745                 750         


Glu Ile Thr Thr Leu Val Ser Arg Val Gly His Glu Pro Lys Lys Trp 
        755                 760                 765             


Pro Ile Ser Gly Val Leu Pro His Ser Gly Gln Leu Val Trp Tyr Met 
    770                 775                 780                 


Asp Tyr Asp Ala Phe Leu Gly 
785                 790     


<210>  35
<211>  7020
<212>  DNA
<213>  Homo sapiens

<400>  35
atggtccgct tcggggacga gctgggcggc cgctatggag gccccggcgg cggagagcgg       60

gcccggggcg gcggggccgg cggggcgggg ggcccgggtc ccggggggct gcagcccggc      120

cagcgggtcc tctacaagca atcgatcgcg cagcgcgcgc ggaccatggc gctgtacaac      180

cccatcccgg tcaagcagaa ctgcttcacc gtcaaccgct cgctcttcgt cttcagcgag      240

gacaacgtcg tccgcaaata cgcgaagcgc atcaccgagt ggcctccatt cgagtatatg      300

atcctggcca ccatcatcgc caactgcatc gtgctggccc tggagcagca cctccctgat      360

ggggacaaaa cgcccatgtc cgagcggctg gacgacacgg agccctattt catcgggatc      420

ttttgcttcg aggcagggat caaaatcatc gctctgggct ttgtcttcca caagggctct      480

tacctgcgga acggctggaa cgtcatggac ttcgtggtcg tcctcacagg gatccttgcc      540

acggctggaa ctgacttcga cctgcgaaca ctgagggctg tgcgtgtgct gaggcccctg      600

aagctggtgt ctgggattcc aagtttgcag gtggtgctca agtccatcat gaaggccatg      660

gttccactcc tgcagattgg gctgcttctc ttctttgcca tcctcatgtt tgccatcatt      720

ggcctggagt tctacatggg caagttccac aaggcctgtt tccccaacag cacagatgcg      780

gagcccgtgg gtgacttccc ctgtggcaag gaggccccag cccggctgtg cgagggcgac      840

actgagtgcc gggagtactg gccaggaccc aactttggca tcaccaactt tgacaatatc      900

ctgtttgcca tcttgacggt gttccagtgc atcaccatgg agggctggac tgacatcctc      960

tataatacaa acgatgcggc cggcaacacc tggaactggc tctacttcat ccctctcatc     1020

atcatcggct ccttcttcat gctcaacctg gtgctgggcg tgctctcggg ggagtttgcc     1080

aaggagcgag agagggtgga gaaccgccgc gccttcctga agctgcgccg gcagcagcag     1140

atcgagcgag agctcaacgg gtacctggag tggatcttca aggcggagga agtcatgctg     1200

gccgaggagg acaggaatgc agaggagaag tcccctttgg acgtgctgaa gagagcggcc     1260

accaagaaga gcagaaatga cctgatccac gcagaggagg gagaggaccg gtttgcagat     1320

ctctgtgctg ttggatcccc cttcgcccgc gccagcctca agagcgggaa gacagagagc     1380

tcgtcatact tccggaggaa ggagaagatg ttccggtttt ttatccggcg catggtgaag     1440

gctcagagct tctactgggt ggtgctgtgc gtggtggccc tgaacacact gtgtgtggcc     1500

atggtgcatt acaaccagcc gcggcggctt accacgaccc tgtattttgc agagtttgtt     1560

ttcctgggtc tcttcctcac agagatgtcc ctgaagatgt atggcctggg gcccagaagc     1620

tacttccggt cctccttcaa ctgcttcgac tttggggtca tcgtggggag cgtctttgaa     1680

gtggtctggg cggccatcaa gccgggaagc tcctttggga tcagtgtgct gcgggccctc     1740

cgcctgctga ggatcttcaa agtcacgaag tactggagct ccctgcggaa cctggtggtg     1800

tccctgctga actccatgaa gtccatcatc agcctgctct tcttgctctt cctgttcatt     1860

gtggtcttcg ccctgctggg gatgcagctg tttgggggac agttcaactt ccaggatgag     1920

actcccacaa ccaacttcga caccttccct gccgccatcc tcactgtctt ccagatcctg     1980

acgggagagg actggaatgc agtgatgtat cacgggatcg aatcgcaagg cggcgtcagc     2040

aaaggcatgt tctcgtcctt ttacttcatt gtcctgacac tgttcggaaa ctacactctg     2100

ctgaatgtct ttctggccat cgctgtggac aacctggcca acgcccaaga gctgaccaag     2160

gatgaagagg agatggaaga agcagccaat cagaagcttg ctctgcaaaa ggccaaagaa     2220

gtggctgaag tcagccccat gtctgccgcg aacatctcca tcgccgccag gcagcagaac     2280

tcggccaagg cgcgctcggt gtgggagcag cgggccagcc agctacggct gcagaacctg     2340

cgggccagct gcgaggcgct gtacagcgag atggaccccg aggagcggct gcgcttcgcc     2400

actacgcgcc acctgcggcc cgacatgaag acgcacctgg accggccgct ggtggtggag     2460

ctgggccgcg acggcgcgcg ggggcccgtg ggaggcaaag cccgacctga ggctgcggag     2520

gcccccgagg gcgtcgaccc tccgcgcagg caccaccggc accgcgacaa ggacaagacc     2580

cccgcggcgg gggaccagga ccgagcagag gccccgaagg cggagagcgg ggagcccggt     2640

gcccgggagg agcggccgcg gccgcaccgc agccacagca aggaggccgc ggggcccccg     2700

gaggcgcgga gcgagcgcgg ccgaggccca ggccccgagg gcggccggcg gcaccaccgg     2760

cgcggctccc cggaggaggc ggccgagcgg gagccccgac gccaccgcgc gcaccggcac     2820

caggatccga gcaaggagtg cgccggcgcc aagggcgagc ggcgcgcgcg gcaccgcggc     2880

ggcccccgag cggggccccg ggaggcggag agcggggagg agccggcgcg gcggcaccgg     2940

gcccggcaca aggcgcagcc tgctcacgag gctgtggaga aggagaccac ggagaaggag     3000

gccacggaga aggaggctga gatagtggaa gccgacaagg aaaaggagct ccggaaccac     3060

cagccccggg agccacactg tgacctggag accagtggga ctgtgactgt gggtcccatg     3120

cacacactgc ccagcacctg tctccagaag gtggaggaac agccagagga tgcagacaat     3180

cagcggaacg tcactcgcat gggcagtcag cccccagacc cgaacactat tgtacatatc     3240

ccagtgatgc tgacgggccc tcttggggaa gccacggtcg ttcccagtgg taacgtggac     3300

ctggaaagcc aagcagaggg gaagaaggag gtggaagcgg atgacgtgat gaggagcggc     3360

ccccggccta tcgtcccata cagctccatg ttctgtttaa gccccaccaa cctgctccgc     3420

cgcttctgcc actacatcgt gaccatgagg tacttcgagg tggtcattct cgtggtcatc     3480

gccttgagca gcatcgccct ggctgctgag gacccagtgc gcacagactc gcccaggaac     3540

aacgctctga aatacctgga ttacattttc actggtgtct ttacctttga gatggtgata     3600

aagatgatcg acttgggact gctgcttcac cctggagcct atttccggga cttgtggaac     3660

attctggact tcattgtggt cagtggcgcc ctggtggcgt ttgctttctc aggatccaaa     3720

gggaaagaca tcaataccat caagtctctg agagtccttc gtgtcctgcg gcccctcaag     3780

accatcaaac ggctgcccaa gctcaaggct gtgtttgact gtgtggtgaa ctccctgaag     3840

aatgtcctca acatcttgat tgtctacatg ctcttcatgt tcatatttgc cgtcattgcg     3900

gtgcagctct tcaaagggaa gtttttctac tgcacagatg aatccaagga gctggagagg     3960

gactgcaggg gtcagtattt ggattatgag aaggaggaag tggaagctca gcccaggcag     4020

tggaagaaat acgactttca ctacgacaat gtgctctggg ctctgctgac gctgttcaca     4080

gtgtccacgg gagaaggctg gcccatggtg ctgaaacact ccgtggatgc cacctatgag     4140

gagcagggtc caagccctgg gtaccgcatg gagctgtcca tcttctacgt ggtctacttt     4200

gtggtctttc ccttcttctt cgtcaacatc tttgtggctt tgatcatcat caccttccag     4260

gagcaggggg acaaggtgat gtctgaatgc agcctggaga agaacgagag ggcttgcatt     4320

gacttcgcca tcagcgccaa acccctgaca cggtacatgc cccaaaaccg gcagtcgttc     4380

cagtataaga cgtggacatt tgtggtctcc ccgccctttg aatacttcat catggccatg     4440

atagccctca acactgtggt gctgatgatg aagttctatg atgcacccta tgagtacgag     4500

ctgatgctga aatgcctgaa catcgtgttc acatccatgt tctccatgga atgcgtgctg     4560

aagatcatcg cctttggggt gctgaactat ttcagagatg cctggaatgt ctttgacttt     4620

gtcactgtgt tgggaagtat tactgatatt ttagtaacag agattgcgga aacgaacaat     4680

ttcatcaacc tcagcttcct ccgcctcttt cgagctgcgc ggctgatcaa gctgctccgc     4740

cagggctaca ccatccgcat cctgctgtgg acctttgtcc agtccttcaa ggccctgccc     4800

tacgtgtgtc tgctcattgc catgctgttc ttcatctacg ccatcatcgg catgcaggtg     4860

tttgggaata ttgccctgga tgatgacacc agcatcaacc gccacaacaa cttccggacg     4920

tttttgcaag ccctgatgct gctgttcagg agcgccacgg gggaggcctg gcacgagatc     4980

atgctgtcct gcctgagcaa ccaggcctgt gatgagcagg ccaatgccac cgagtgtgga     5040

agtgactttg cctacttcta cttcgtctcc ttcatcttcc tgtgctcctt tctgatgttg     5100

aacctctttg tggctgtgat catggacaat tttgagtacc tcacgcggga ctcttccatc     5160

ctaggtcctc accacttgga tgagttcatc cgggtctggg ctgaatacga cccggctgcg     5220

tgtgggcgca tcagttacaa tgacatgttt gagatgctga aacacatgtc cccgcctctg     5280

gggctgggga agaaatgccc tgctcgagtt gcttacaagc gcctggttcg catgaacatg     5340

cccatctcca acgaggacat gactgttcac ttcacgtcca cgctgatggc cctcatccgg     5400

acggcactgg agatcaagct ggccccagct gggacaaagc agcatcagtg tgacgcggag     5460

ttgaggaagg agatttccgt tgtgtgggcc aatctgcccc agaagacttt ggacttgctg     5520

gtaccacccc ataagcctga tgagatgaca gtggggaagg tttatgcagc tctgatgata     5580

tttgacttct acaagcagaa caaaaccacc agagaccaga tgcagcaggc tcctggaggc     5640

ctctcccaga tgggtcctgt gtccctgttc caccctctga aggccaccct ggagcagaca     5700

cagccggctg tgctccgagg agcccgggtt ttccttcgac agaagagttc cacctccctc     5760

agcaatggcg gggccataca aaaccaagag agtggcatca aagagtctgt ctcctggggc     5820

actcaaagga cccaggatgc accccatgag gccaggccac ccctggagcg tggccactcc     5880

acagagatcc ctgtggggcg gtcaggagca ctggctgtgg acgttcagat gcagagcata     5940

acccggaggg gccctgatgg ggagccccag cctgggctgg agagccaggg tcgagcggcc     6000

tccatgcccc gccttgcggc cgagactcag cccgtcacag atgccagccc catgaagcgc     6060

tccatctcca cgctggccca gcggccccgt gggactcatc tttgcagcac caccccggac     6120

cgcccacccc ctagccaggc gtcgtcgcac caccaccacc accgctgcca ccgccgcagg     6180

gacaggaagc agaggtccct ggagaagggg cccagcctgt ctgccgatat ggatggcgca     6240

ccaagcagtg ctgtggggcc ggggctgccc ccgggagagg ggcctacagg ctgccggcgg     6300

gaacgagagc gccggcagga gcggggccgg tcccaggagc ggaggcagcc ctcatcctcc     6360

tcctcggaga agcagcgctt ctactcctgc gaccgctttg ggggccgtga gcccccgaag     6420

cccaagccct ccctcagcag ccacccaacg tcgccaacag ctggccagga gccgggaccc     6480

cacccacagg gcagtggttc cgtgaatggg agccccttgc tgtcaacatc tggtgctagc     6540

acccccggcc gcggtgggcg gaggcagctc ccccagacgc ccctgactcc ccgccccagc     6600

atcacctaca agacggccaa ctcctcaccc atccacttcg ccggggctca gaccagcctc     6660

cctgccttct ccccaggccg gctcagccgt gggctttccg aacacaacgc cctgctgcag     6720

agagaccccc tcagccagcc cctggcccct ggctctcgaa ttggctctga cccttacctg     6780

gggcagcgtc tggacagtga ggcctctgtc cacgccctgc ctgaggacac gctcactttc     6840

gaggaggctg tggccaccaa ctcgggccgc tcctccagga cttcctacgt gtcctccctg     6900

acctcccagt ctcaccctct ccgccgcgtg cccaacggtt accactgcac cctgggactc     6960

agctcgggtg gccgagcacg gcacagctac caccaccctg accaagacca ctggtgctag     7020


<210>  36
<211>  2339
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro 
            20                  25                  30          


Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser 
        35                  40                  45              


Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val 
    50                  55                  60                  


Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu 
65                  70                  75                  80  


Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Pro 
                85                  90                  95      


Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys Ile Val Leu 
            100                 105                 110         


Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr Pro Met Ser Glu 
        115                 120                 125             


Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu 
    130                 135                 140                 


Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe His Lys Gly Ser 
145                 150                 155                 160 


Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Thr 
                165                 170                 175     


Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu Arg Thr Leu Arg 
            180                 185                 190         


Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser 
        195                 200                 205             


Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu 
    210                 215                 220                 


Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile 
225                 230                 235                 240 


Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala Cys Phe Pro Asn 
                245                 250                 255     


Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys Gly Lys Glu Ala 
            260                 265                 270         


Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg Glu Tyr Trp Pro 
        275                 280                 285             


Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile Leu Phe Ala Ile 
    290                 295                 300                 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Ile Leu 
305                 310                 315                 320 


Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn Trp Leu Tyr Phe 
                325                 330                 335     


Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu Asn Leu Val Leu 
            340                 345                 350         


Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn 
        355                 360                 365             


Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu 
    370                 375                 380                 


Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu Glu Val Met Leu 
385                 390                 395                 400 


Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro Leu Asp Val Leu 
                405                 410                 415     


Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu Ile His Ala Glu 
            420                 425                 430         


Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val Gly Ser Pro Phe 
        435                 440                 445             


Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser Ser Ser Tyr Phe 
    450                 455                 460                 


Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg Arg Met Val Lys 
465                 470                 475                 480 


Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val Ala Leu Asn Thr 
                485                 490                 495     


Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg Arg Leu Thr Thr 
            500                 505                 510         


Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu Phe Leu Thr Glu 
        515                 520                 525             


Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser Tyr Phe Arg Ser 
    530                 535                 540                 


Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly Ser Val Phe Glu 
545                 550                 555                 560 


Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe Gly Ile Ser Val 
                565                 570                 575     


Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val Thr Lys Tyr Trp 
            580                 585                 590         


Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn Ser Met Lys Ser 
        595                 600                 605             


Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile Val Val Phe Ala 
    610                 615                 620                 


Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn Phe Gln Asp Glu 
625                 630                 635                 640 


Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala Ile Leu Thr Val 
                645                 650                 655     


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr His Gly 
            660                 665                 670         


Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe Ser Ser Phe Tyr 
        675                 680                 685             


Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe 
    690                 695                 700                 


Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys 
705                 710                 715                 720 


Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys Leu Ala Leu Gln 
                725                 730                 735     


Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser Ala Ala Asn Ile 
            740                 745                 750         


Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala Arg Ser Val Trp 
        755                 760                 765             


Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu Arg Ala Ser Cys 
    770                 775                 780                 


Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg Leu Arg Phe Ala 
785                 790                 795                 800 


Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His Leu Asp Arg Pro 
                805                 810                 815     


Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly Pro Val Gly Gly 
            820                 825                 830         


Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly Val Asp Pro Pro 
        835                 840                 845             


Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr Pro Ala Ala Gly 
    850                 855                 860                 


Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser Gly Glu Pro Gly 
865                 870                 875                 880 


Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His Ser Lys Glu Ala 
                885                 890                 895     


Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg Gly Pro Gly Pro 
            900                 905                 910         


Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro Glu Glu Ala Ala 
        915                 920                 925             


Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His Gln Asp Pro Ser 
    930                 935                 940                 


Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala Arg His Arg Gly 
945                 950                 955                 960 


Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly Glu Glu Pro Ala 
                965                 970                 975     


Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala His Glu Ala Val 
            980                 985                 990         


Glu Lys Glu Thr Thr Glu Lys Glu  Ala Thr Glu Lys Glu  Ala Glu Ile 
        995                 1000                 1005             


Val Glu  Ala Asp Lys Glu Lys  Glu Leu Arg Asn His  Gln Pro Arg 
    1010                 1015                 1020             


Glu Pro  His Cys Asp Leu Glu  Thr Ser Gly Thr Val  Thr Val Gly 
    1025                 1030                 1035             


Pro Met  His Thr Leu Pro Ser  Thr Cys Leu Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Gln Pro  Glu Asp Ala Asp Asn  Gln Arg Asn Val Thr  Arg Met Gly 
    1055                 1060                 1065             


Ser Gln  Pro Pro Asp Pro Asn  Thr Ile Val His Ile  Pro Val Met 
    1070                 1075                 1080             


Leu Thr  Gly Pro Leu Gly Glu  Ala Thr Val Val Pro  Ser Gly Asn 
    1085                 1090                 1095             


Val Asp  Leu Glu Ser Gln Ala  Glu Gly Lys Lys Glu  Val Glu Ala 
    1100                 1105                 1110             


Asp Asp  Val Met Arg Ser Gly  Pro Arg Pro Ile Val  Pro Tyr Ser 
    1115                 1120                 1125             


Ser Met  Phe Cys Leu Ser Pro  Thr Asn Leu Leu Arg  Arg Phe Cys 
    1130                 1135                 1140             


His Tyr  Ile Val Thr Met Arg  Tyr Phe Glu Val Val  Ile Leu Val 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Ile  Ala Leu Ala Ala Glu  Asp Pro Val 
    1160                 1165                 1170             


Arg Thr  Asp Ser Pro Arg Asn  Asn Ala Leu Lys Tyr  Leu Asp Tyr 
    1175                 1180                 1185             


Ile Phe  Thr Gly Val Phe Thr  Phe Glu Met Val Ile  Lys Met Ile 
    1190                 1195                 1200             


Asp Leu  Gly Leu Leu Leu His  Pro Gly Ala Tyr Phe  Arg Asp Leu 
    1205                 1210                 1215             


Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser Gly Ala  Leu Val Ala 
    1220                 1225                 1230             


Phe Ala  Phe Ser Gly Ser Lys  Gly Lys Asp Ile Asn  Thr Ile Lys 
    1235                 1240                 1245             


Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro Leu Lys  Thr Ile Lys 
    1250                 1255                 1260             


Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp Cys Val  Val Asn Ser 
    1265                 1270                 1275             


Leu Lys  Asn Val Leu Asn Ile  Leu Ile Val Tyr Met  Leu Phe Met 
    1280                 1285                 1290             


Phe Ile  Phe Ala Val Ile Ala  Val Gln Leu Phe Lys  Gly Lys Phe 
    1295                 1300                 1305             


Phe Tyr  Cys Thr Asp Glu Ser  Lys Glu Leu Glu Arg  Asp Cys Arg 
    1310                 1315                 1320             


Gly Gln  Tyr Leu Asp Tyr Glu  Lys Glu Glu Val Glu  Ala Gln Pro 
    1325                 1330                 1335             


Arg Gln  Trp Lys Lys Tyr Asp  Phe His Tyr Asp Asn  Val Leu Trp 
    1340                 1345                 1350             


Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr Gly Glu  Gly Trp Pro 
    1355                 1360                 1365             


Met Val  Leu Lys His Ser Val  Asp Ala Thr Tyr Glu  Glu Gln Gly 
    1370                 1375                 1380             


Pro Ser  Pro Gly Tyr Arg Met  Glu Leu Ser Ile Phe  Tyr Val Val 
    1385                 1390                 1395             


Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val Asn Ile  Phe Val Ala 
    1400                 1405                 1410             


Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly Asp Lys  Val Met Ser 
    1415                 1420                 1425             


Glu Cys  Ser Leu Glu Lys Asn  Glu Arg Ala Cys Ile  Asp Phe Ala 
    1430                 1435                 1440             


Ile Ser  Ala Lys Pro Leu Thr  Arg Tyr Met Pro Gln  Asn Arg Gln 
    1445                 1450                 1455             


Ser Phe  Gln Tyr Lys Thr Trp  Thr Phe Val Val Ser  Pro Pro Phe 
    1460                 1465                 1470             


Glu Tyr  Phe Ile Met Ala Met  Ile Ala Leu Asn Thr  Val Val Leu 
    1475                 1480                 1485             


Met Met  Lys Phe Tyr Asp Ala  Pro Tyr Glu Tyr Glu  Leu Met Leu 
    1490                 1495                 1500             


Lys Cys  Leu Asn Ile Val Phe  Thr Ser Met Phe Ser  Met Glu Cys 
    1505                 1510                 1515             


Val Leu  Lys Ile Ile Ala Phe  Gly Val Leu Asn Tyr  Phe Arg Asp 
    1520                 1525                 1530             


Ala Trp  Asn Val Phe Asp Phe  Val Thr Val Leu Gly  Ser Ile Thr 
    1535                 1540                 1545             


Asp Ile  Leu Val Thr Glu Ile  Ala Glu Thr Asn Asn  Phe Ile Asn 
    1550                 1555                 1560             


Leu Ser  Phe Leu Arg Leu Phe  Arg Ala Ala Arg Leu  Ile Lys Leu 
    1565                 1570                 1575             


Leu Arg  Gln Gly Tyr Thr Ile  Arg Ile Leu Leu Trp  Thr Phe Val 
    1580                 1585                 1590             


Gln Ser  Phe Lys Ala Leu Pro  Tyr Val Cys Leu Leu  Ile Ala Met 
    1595                 1600                 1605             


Leu Phe  Phe Ile Tyr Ala Ile  Ile Gly Met Gln Val  Phe Gly Asn 
    1610                 1615                 1620             


Ile Ala  Leu Asp Asp Asp Thr  Ser Ile Asn Arg His  Asn Asn Phe 
    1625                 1630                 1635             


Arg Thr  Phe Leu Gln Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr 
    1640                 1645                 1650             


Gly Glu  Ala Trp His Glu Ile  Met Leu Ser Cys Leu  Ser Asn Gln 
    1655                 1660                 1665             


Ala Cys  Asp Glu Gln Ala Asn  Ala Thr Glu Cys Gly  Ser Asp Phe 
    1670                 1675                 1680             


Ala Tyr  Phe Tyr Phe Val Ser  Phe Ile Phe Leu Cys  Ser Phe Leu 
    1685                 1690                 1695             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1700                 1705                 1710             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1715                 1720                 1725             


Phe Ile  Arg Val Trp Ala Glu  Tyr Asp Pro Ala Ala  Cys Gly Arg 
    1730                 1735                 1740             


Ile Ser  Tyr Asn Asp Met Phe  Glu Met Leu Lys His  Met Ser Pro 
    1745                 1750                 1755             


Pro Leu  Gly Leu Gly Lys Lys  Cys Pro Ala Arg Val  Ala Tyr Lys 
    1760                 1765                 1770             


Arg Leu  Val Arg Met Asn Met  Pro Ile Ser Asn Glu  Asp Met Thr 
    1775                 1780                 1785             


Val His  Phe Thr Ser Thr Leu  Met Ala Leu Ile Arg  Thr Ala Leu 
    1790                 1795                 1800             


Glu Ile  Lys Leu Ala Pro Ala  Gly Thr Lys Gln His  Gln Cys Asp 
    1805                 1810                 1815             


Ala Glu  Leu Arg Lys Glu Ile  Ser Val Val Trp Ala  Asn Leu Pro 
    1820                 1825                 1830             


Gln Lys  Thr Leu Asp Leu Leu  Val Pro Pro His Lys  Pro Asp Glu 
    1835                 1840                 1845             


Met Thr  Val Gly Lys Val Tyr  Ala Ala Leu Met Ile  Phe Asp Phe 
    1850                 1855                 1860             


Tyr Lys  Gln Asn Lys Thr Thr  Arg Asp Gln Met Gln  Gln Ala Pro 
    1865                 1870                 1875             


Gly Gly  Leu Ser Gln Met Gly  Pro Val Ser Leu Phe  His Pro Leu 
    1880                 1885                 1890             


Lys Ala  Thr Leu Glu Gln Thr  Gln Pro Ala Val Leu  Arg Gly Ala 
    1895                 1900                 1905             


Arg Val  Phe Leu Arg Gln Lys  Ser Ser Thr Ser Leu  Ser Asn Gly 
    1910                 1915                 1920             


Gly Ala  Ile Gln Asn Gln Glu  Ser Gly Ile Lys Glu  Ser Val Ser 
    1925                 1930                 1935             


Trp Gly  Thr Gln Arg Thr Gln  Asp Ala Pro His Glu  Ala Arg Pro 
    1940                 1945                 1950             


Pro Leu  Glu Arg Gly His Ser  Thr Glu Ile Pro Val  Gly Arg Ser 
    1955                 1960                 1965             


Gly Ala  Leu Ala Val Asp Val  Gln Met Gln Ser Ile  Thr Arg Arg 
    1970                 1975                 1980             


Gly Pro  Asp Gly Glu Pro Gln  Pro Gly Leu Glu Ser  Gln Gly Arg 
    1985                 1990                 1995             


Ala Ala  Ser Met Pro Arg Leu  Ala Ala Glu Thr Gln  Pro Val Thr 
    2000                 2005                 2010             


Asp Ala  Ser Pro Met Lys Arg  Ser Ile Ser Thr Leu  Ala Gln Arg 
    2015                 2020                 2025             


Pro Arg  Gly Thr His Leu Cys  Ser Thr Thr Pro Asp  Arg Pro Pro 
    2030                 2035                 2040             


Pro Ser  Gln Ala Ser Ser His  His His His His Arg  Cys His Arg 
    2045                 2050                 2055             


Arg Arg  Asp Arg Lys Gln Arg  Ser Leu Glu Lys Gly  Pro Ser Leu 
    2060                 2065                 2070             


Ser Ala  Asp Met Asp Gly Ala  Pro Ser Ser Ala Val  Gly Pro Gly 
    2075                 2080                 2085             


Leu Pro  Pro Gly Glu Gly Pro  Thr Gly Cys Arg Arg  Glu Arg Glu 
    2090                 2095                 2100             


Arg Arg  Gln Glu Arg Gly Arg  Ser Gln Glu Arg Arg  Gln Pro Ser 
    2105                 2110                 2115             


Ser Ser  Ser Ser Glu Lys Gln  Arg Phe Tyr Ser Cys  Asp Arg Phe 
    2120                 2125                 2130             


Gly Gly  Arg Glu Pro Pro Lys  Pro Lys Pro Ser Leu  Ser Ser His 
    2135                 2140                 2145             


Pro Thr  Ser Pro Thr Ala Gly  Gln Glu Pro Gly Pro  His Pro Gln 
    2150                 2155                 2160             


Gly Ser  Gly Ser Val Asn Gly  Ser Pro Leu Leu Ser  Thr Ser Gly 
    2165                 2170                 2175             


Ala Ser  Thr Pro Gly Arg Gly  Gly Arg Arg Gln Leu  Pro Gln Thr 
    2180                 2185                 2190             


Pro Leu  Thr Pro Arg Pro Ser  Ile Thr Tyr Lys Thr  Ala Asn Ser 
    2195                 2200                 2205             


Ser Pro  Ile His Phe Ala Gly  Ala Gln Thr Ser Leu  Pro Ala Phe 
    2210                 2215                 2220             


Ser Pro  Gly Arg Leu Ser Arg  Gly Leu Ser Glu His  Asn Ala Leu 
    2225                 2230                 2235             


Leu Gln  Arg Asp Pro Leu Ser  Gln Pro Leu Ala Pro  Gly Ser Arg 
    2240                 2245                 2250             


Ile Gly  Ser Asp Pro Tyr Leu  Gly Gln Arg Leu Asp  Ser Glu Ala 
    2255                 2260                 2265             


Ser Val  His Ala Leu Pro Glu  Asp Thr Leu Thr Phe  Glu Glu Ala 
    2270                 2275                 2280             


Val Ala  Thr Asn Ser Gly Arg  Ser Ser Arg Thr Ser  Tyr Val Ser 
    2285                 2290                 2295             


Ser Leu  Thr Ser Gln Ser His  Pro Leu Arg Arg Val  Pro Asn Gly 
    2300                 2305                 2310             


Tyr His  Cys Thr Leu Gly Leu  Ser Ser Gly Gly Arg  Ala Arg His 
    2315                 2320                 2325             


Ser Tyr  His His Pro Asp Gln  Asp His Trp Cys 
    2330                 2335                 


<210>  37
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  37
atgcgcctcc gccgcctagc gctgttcccg ggtgtggcgc tgcttcttgc cgcggcccgc       60

ctcgccgctg cctccgacgt gctagaactc acggacgaca acttcgagag tcgcatctcc      120

gacacgggct ctgcgggcct catgctcgtc gagttcttcg ccccctggtg tggacactgc      180

aagagacttg cacctgagta tgaagctgca gctaccagat taaaaggaat agtcccatta      240

gcaaaggttg attgcactgc caacactaac acctgtaata aatatggagt cagtggatat      300

ccaaccctga agatatttag agatggtgaa gaagcaggtg cttatgatgg acctaggact      360

gctgatggaa ttgtcagcca cttgaagaag caggcaggac cagcttcagt gcctctcagg      420

actgaggaag aatttaagaa attcattagt gataaagatg cctctatagt aggttttttc      480

gatgattcat tcagtgaggc tcactccgag ttcctaaaag cagccagcaa cttgagggat      540

aactaccgat ttgcacatac gaatgttgag tctctggtga acgagtatga tgataatgga      600

gagggtatca tcttatttcg tccttcacat ctcactaaca agtttgagga caagactgtg      660

gcatatacag agcaaaaaat gaccagtggc aaaattaaaa agtttatcca ggaaaacatt      720

tttggtatct gccctcacat gacagaagac aataaagatt tgatacaggg caaggactta      780

cttattgctt actatgatgt ggactatgaa aagaacgcta aaggttccaa ctactggaga      840

aacagggtaa tgatggtggc aaagaaattc ctggatgctg ggcacaaact caactttgct      900

gtagctagcc gcaaaacctt tagccatgaa ctttctgatt ttggcttgga gagcactgct      960

ggagagattc ctgttgttgc tatcagaact gctaaaggag agaagtttgt catgcaggag     1020

gagttctcgc gtgatgggaa ggctctggag aggttcctgc aggattactt tgatggcaat     1080

ctgaagagat acctgaagtc tgaacctatc ccagagagca atgatgggcc tgtgaaggta     1140

gtggtagcag agaattttga tgaaatagtg aataatgaaa ataaagatgt gctgattgaa     1200

ttttatgccc cttggtgtgg tcactgtaag aacctggagc ccaagtataa agaacttggc     1260

gagaagctca gcaaagaccc aaatatcgtc atagccaaga tggatgccac agccaatgat     1320

gtgccttctc catatgaagt cagaggtttt cctaccatat acttctctcc agccaacaag     1380

aagctaaatc caaagaaata tgaaggtggc cgtgaattaa gtgattttat tagctatcta     1440

caaagagaag ctacaaaccc ccctgtaatt caagaagaaa aacccaagaa gaagaagaag     1500

gcacaggagg atctctaa                                                   1518


<210>  38
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  39
<211>  4065
<212>  DNA
<213>  Homo sapiens

<400>  39
atgtcgactg gggacagttt tgagactcga tttgaaaaaa tggacaacct gctgcgggat       60

cccaaatcgg aagtgaattc ggattgtttg ctggatggat tggatgcttt ggtatatgat      120

ttggattttc ctgccttaag aaaaaacaaa aatattgaca actttttaag cagatataaa      180

gacacaataa ataaaatcag agatttacga atgaaagctg aagattatga agtagtgaag      240

gtgattggta gaggtgcatt tggagaagtt caattggtaa ggcataaatc caccaggaag      300

gtatatgcta tgaagcttct cagcaaattt gaaatgataa agagatctga ttctgctttt      360

ttctgggaag aaagggacat catggctttt gccaacagtc cttgggttgt tcagcttttt      420

tatgcattcc aagatgatcg ttatctctac atggtgatgg aatacatgcc tggtggagat      480

cttgtaaact taatgagcaa ctatgatgtg cctgaaaaat gggcacgatt ctatactgca      540

gaagtagttc ttgcattgga tgcaatccat tccatgggtt ttattcacag agatgtgaag      600

cctgataaca tgctgctgga taaatctgga catttgaagt tagcagattt tggtacttgt      660

atgaagatga ataaggaagg catggtacga tgtgatacag cggttggaac acctgattat      720

atttcccctg aagtattaaa atcccaaggt ggtgatggtt attatggaag agaatgtgac      780

tggtggtcgg ttggggtatt tttatacgaa atgcttgtag gtgatacacc tttttatgca      840

gattctttgg ttggaactta cagtaaaatt atgaaccata aaaattcact tacctttcct      900

gatgataatg acatatcaaa agaagcaaaa aaccttattt gtgccttcct tactgacagg      960

gaagtgaggt tagggcgaaa tggtgtagaa gaaatcaaac gacatctctt cttcaaaaat     1020

gaccagtggg cttgggaaac gctccgagac actgtagcac cagttgtacc cgatttaagt     1080

agtgacattg atactagtaa ttttgatgac ttggaagaag ataaaggaga ggaagaaaca     1140

ttccctattc ctaaagcttt cgttggcaat caactacctt ttgtaggatt tacatattat     1200

agcaatcgta gatacttatc ttcagcaaat cctaatgata acagaactag ctccaatgca     1260

gataaaagct tgcaggaaag tttgcaaaaa acaatctata agctggaaga acagctgcat     1320

aatgaaatgc agttaaaaga tgaaatggag cagaagtgca gaacctcaaa cataaaacta     1380

gacaagataa tgaaagaatt ggatgaagag ggaaatcaaa gaagaaatct agaatctaca     1440

gtgtctcaga ttgagaagga gaaaatgttg ctacagcata gaattaatga gtaccaaaga     1500

aaagctgaac aggaaaatga gaagagaaga aatgtagaaa atgaagtttc tacattaaag     1560

gatcagttgg aagacttaaa gaaagtcagt cagaattcac agcttgctaa tgagaagctg     1620

tcccagttac aaaagcagct agaagaagcc aatgacttac ttaggacaga atcggacaca     1680

gctgtaagat tgaggaagag tcacacagag atgagcaagt caattagtca gttagagtcc     1740

ctgaacagag agttgcaaga gagaaatcga attttagaga attctaagtc acaaacagac     1800

aaagattatt accagctgca agctatatta gaagctgaac gaagagacag aggtcatgat     1860

tctgagatga ttggagacct tcaagctcga attacatctt tacaagagga ggtgaagcat     1920

ctcaaacata atctcgaaaa agtggaagga gaaagaaaag aggctcaaga catgcttaat     1980

cactcagaaa aggaaaagaa taatttagag atagatttaa actacaaact taaatcatta     2040

caacaacggt tagaacaaga ggtaaatgaa cacaaagtaa ccaaagctcg tttaactgac     2100

aaacatcaat ctattgaaga ggcaaagtct gtggcaatgt gtgagatgga aaaaaagctg     2160

aaagaagaaa gagaagctcg agagaaggct gaaaatcggg ttgttcagat tgagaaacag     2220

tgttccatgc tagacgttga tctgaagcaa tctcagcaga aactagaaca tttgactgga     2280

aataaagaaa ggatggagga tgaagttaag aatctaaccc tgcaactgga gcaggaatca     2340

aataagcggc tgttgttaca aaatgaattg aagactcaag catttgaggc agacaattta     2400

aaaggtttag aaaagcagat gaaacaggaa ataaatactt tattggaagc aaagagatta     2460

ttagaatttg agttagctca gcttacgaaa cagtatagag gaaatgaagg acagatgcgg     2520

gagctacaag atcagcttga agctgagcaa tatttctcga cactttataa aacccaggta     2580

aaggaactta aagaagaaat tgaagaaaaa aacagagaaa atttaaagaa aatacaggaa     2640

ctacaaaatg aaaaagaaac tcttgctact cagttggatc tagcagaaac aaaagctgag     2700

tctgagcagt tggcgcgagg ccttctggaa gaacagtatt ttgaattgac gcaagaaagc     2760

aagaaagctg cttcaagaaa tagacaagag attacagata aagatcacac tgttagtcgg     2820

cttgaagaag caaacagcat gctaaccaaa gatattgaaa tattaagaag agagaatgaa     2880

gagctaacag agaaaatgaa gaaggcagag gaagaatata aactggagaa ggaggaggag     2940

atcagtaatc ttaaggctgc ctttgaaaag aatatcaaca ctgaacgaac ccttaaaaca     3000

caggctgtta acaaattggc agaaataatg aatcgaaaag attttaaaat tgatagaaag     3060

aaagctaata cacaagattt gagaaagaaa gaaaaggaaa atcgaaagct gcaactggaa     3120

ctcaaccaag aaagagagaa attcaaccag atggtagtga aacatcagaa ggaactgaat     3180

gacatgcaag cgcaattggt agaagaatgt gcacatagga atgagcttca gatgcagttg     3240

gccagcaaag agagtgatat tgagcaattg cgtgctaaac ttttggacct ctcggattct     3300

acaagtgttg ctagttttcc tagtgctgat gaaactgatg gtaacctccc agagtcaaga     3360

attgaaggtt ggctttcagt accaaataga ggaaatatca aacgatatgg ctggaagaaa     3420

cagtatgttg tggtaagcag caaaaaaatt ttgttctata atgacgaaca agataaggag     3480

caatccaatc catctatggt attggacata gataaactgt ttcacgttag acctgtaacc     3540

caaggagatg tgtatagagc tgaaactgaa gaaattccta aaatattcca gatactatat     3600

gcaaatgaag gtgaatgtag aaaagatgta gagatggaac cagtacaaca agctgaaaaa     3660

actaatttcc aaaatcacaa aggccatgag tttattccta cactctacca ctttcctgcc     3720

aattgtgatg cctgtgccaa acctctctgg catgttttta agccaccccc tgccctagag     3780

tgtcgaagat gccatgttaa gtgccacaga gatcacttag ataagaaaga ggacttaatt     3840

tgtccatgta aagtaagtta tgatgtaaca tcagcaagag atatgctgct gttagcatgt     3900

tctcaggatg aacaaaaaaa atgggtaact catttagtaa agaaaatccc taagaatcca     3960

ccatctggtt ttgttcgtgc ttcccctcga acgctttcta caagatccac tgcaaatcag     4020

tctttccgga aagtggtcaa aaatacatct ggaaaaacta gttaa                     4065


<210>  40
<211>  1354
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210>  41
<211>  2628
<212>  DNA
<213>  Homo sapiens

<400>  41
atgaacttcc aggcgggcgg ggggcagagc ccgcagcagc agcagcagct ggccggcggg       60

cccccccagc agttcgcgct ctccaactcc gcggccatcc gggccgagat ccagcgcttc      120

gagtccgtgc atcccaatat ctacgccatc tacgacctga tcgagcgcat cgaggatttg      180

gcgctgcaga accagatccg ggagcacgtc atctccatcg aggactcgtt tgtgaacagc      240

caggagtgga cgctgagccg ctccgtaccg gagcttaaag tgggcatagt ggggaacctg      300

tctagcggga agtcagccct ggtgcaccgc tatctgacgg ggacctatgt ccaggaggag      360

tcccctgaag gggggcggtt taagaaggag attgtggtgg atggccagag ttacctgctg      420

ctgatccgag atgaaggagg cccccctgag ctccagtttg ctgcctgggt ggatgcagtg      480

gtgtttgtgt tcagcctgga ggatgaaatc agtttccaga cggtgtacaa ctacttcctg      540

cgtctctgca gcttccgcaa cgccagcgag gtgcccatgg tgcttgtggg cacgcaggat      600

gccatcagcg ctgcgaatcc ccgggttatc gacgacagca gagcccgcaa gctctccaca      660

gatctgaagc ggtgcaccta ctatgagacg tgcgcgacct acgggctcaa tgtggagcgt      720

gtcttccagg acgtggccca gaaggtagtg gccttgcgaa agaagcagca actggccatc      780

gggccctgca agtcactgcc caactcgccc agccactcgg ccgtgtccgc cgcctccatc      840

ccggccgtgc acatcaacca ggccacgaat ggcggcggca gcgccttcag cgactactcg      900

tcctcagtcc cctccacccc cagcatcagc cagcgggagc tgcgcatcga gaccatcgct      960

gcctcctcca cccccacacc catccgaaag cagtccaagc ggcgctccaa catcttcacg     1020

tctcggaagg gtgctgacct ggaccgggag aagaaggctg ccgagtgcaa ggtggacagc     1080

atcgggagcg gccgcgccat ccccatcaag caggggatcc tgctaaagcg gagcggcaag     1140

tccctgaaca aggagtggaa gaagaagtat gtgacgctct gtgacaacgg gctgctcacc     1200

tatcacccca gcctgcatga ttacatgcag aacatccacg gcaaggagat tgacctgctg     1260

cggacaacgg tgaaagtgcc agggaagcgc ctgccccgag ccacacctgc cacagccccg     1320

ggcaccagcc cccgtgccaa cgggctgtcc gtggagcgga gtaacacaca gctgggtggg     1380

ggcacaggtg ccccccactc ggccagcagc gcatccctgc actctgagcg ccccctcagc     1440

agctcggcct gggctggccc gcgccctgag gggctgcacc agcgctcctg ctccgtttcc     1500

agcgccgacc agtggagtga ggccaccact tccctgcccc caggcatgca gcaccctgcc     1560

agtggcccag ctgaggtact cagttccagc cccaagctgg atcctccccc atctccccac     1620

tccaaccgga agaagcaccg gaggaaaaag agcaccggga ccccccgacc agacggcccc     1680

agcagtgcta ctgaagaggc agaggagtcg tttgaatttg tggtggtgtc cctcactggg     1740

cagacgtggc acttcgaggc ttcaacggcg gaggagcggg agctgtgggt tcagagtgtg     1800

caggcccaga tccttgccag cctgcaaggc tgccgcagtg ccaaggacaa gactcgactg     1860

gggaaccaga acgcagctct ggctgtgcag gccgtccgca ccgtccgcgg caacagcttt     1920

tgtatcgact gcgatgcacc caatccagac tgggccagcc tgaacctggg tgccctgatg     1980

tgcattgagt gctcaggcat ccaccgacac ctgggggctc acctgtcccg ggtgcgctcc     2040

cttgacctcg atgactggcc gcctgagctg ctggctgtca tgactgccat gggcaatgcc     2100

ctcgccaaca gcgtctggga gggggccttg ggtggctact ccaagccagg gcctgatgcc     2160

tgcagagagg agaaggaacg ctggatacgg gccaagtatg aacagaagct cttcctggcc     2220

ccactgccaa gctcagatgt gccactgggg cagcagctgc tccgggccgt ggtggaagat     2280

gacctgcggc tgttggtgat gctcctggca catggctcca aagaggaggt gaatgagacc     2340

tatggggacg gggacgggcg gacggctcta catctctcca gtgccatggc caacgttgtc     2400

ttcacgcagc tgctcatctg gtacggggtg gacgtgagga gccgggacgc ccggggcctg     2460

actccactgg catatgctcg ccgggccggc agccaggagt gtgcagacat cttgatccag     2520

catggctgcc ctggggaggg ctgtggctta gcgcctaccc ccaacagaga gcctgccaat     2580

ggcaccaacc cctctgctga gctgcaccgt agtcctagcc tcctataa                  2628


<210>  42
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Gln 
1               5                   10                  15      


Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser Asn Ser Ala Ala 
            20                  25                  30          


Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr 
        35                  40                  45              


Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu Ala Leu Gln Asn 
    50                  55                  60                  


Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser Phe Val Asn Ser 
65                  70                  75                  80  


Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile 
                85                  90                  95      


Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu 
            100                 105                 110         


Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys 
        115                 120                 125             


Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp 
    130                 135                 140                 


Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp Val Asp Ala Val 
145                 150                 155                 160 


Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr 
                165                 170                 175     


Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala Ser Glu Val Pro 
            180                 185                 190         


Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala Ala Asn Pro Arg 
        195                 200                 205             


Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr Asp Leu Lys Arg 
    210                 215                 220                 


Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg 
225                 230                 235                 240 


Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys Gln 
                245                 250                 255     


Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His 
            260                 265                 270         


Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln Ala 
        275                 280                 285             


Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val Pro 
    290                 295                 300                 


Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Thr Ile Ala 
305                 310                 315                 320 


Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser Lys Arg Arg Ser 
                325                 330                 335     


Asn Ile Phe Thr Ser Arg Lys Gly Ala Asp Leu Asp Arg Glu Lys Lys 
            340                 345                 350         


Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro 
        355                 360                 365             


Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys 
    370                 375                 380                 


Glu Trp Lys Lys Lys Tyr Val Thr Leu Cys Asp Asn Gly Leu Leu Thr 
385                 390                 395                 400 


Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile His Gly Lys Glu 
                405                 410                 415     


Ile Asp Leu Leu Arg Thr Thr Val Lys Val Pro Gly Lys Arg Leu Pro 
            420                 425                 430         


Arg Ala Thr Pro Ala Thr Ala Pro Gly Thr Ser Pro Arg Ala Asn Gly 
        435                 440                 445             


Leu Ser Val Glu Arg Ser Asn Thr Gln Leu Gly Gly Gly Thr Gly Ala 
    450                 455                 460                 


Pro His Ser Ala Ser Ser Ala Ser Leu His Ser Glu Arg Pro Leu Ser 
465                 470                 475                 480 


Ser Ser Ala Trp Ala Gly Pro Arg Pro Glu Gly Leu His Gln Arg Ser 
                485                 490                 495     


Cys Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala Thr Thr Ser Leu 
            500                 505                 510         


Pro Pro Gly Met Gln His Pro Ala Ser Gly Pro Ala Glu Val Leu Ser 
        515                 520                 525             


Ser Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ser Asn Arg Lys 
    530                 535                 540                 


Lys His Arg Arg Lys Lys Ser Thr Gly Thr Pro Arg Pro Asp Gly Pro 
545                 550                 555                 560 


Ser Ser Ala Thr Glu Glu Ala Glu Glu Ser Phe Glu Phe Val Val Val 
                565                 570                 575     


Ser Leu Thr Gly Gln Thr Trp His Phe Glu Ala Ser Thr Ala Glu Glu 
            580                 585                 590         


Arg Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile Leu Ala Ser Leu 
        595                 600                 605             


Gln Gly Cys Arg Ser Ala Lys Asp Lys Thr Arg Leu Gly Asn Gln Asn 
    610                 615                 620                 


Ala Ala Leu Ala Val Gln Ala Val Arg Thr Val Arg Gly Asn Ser Phe 
625                 630                 635                 640 


Cys Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala Ser Leu Asn Leu 
                645                 650                 655     


Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg His Leu Gly 
            660                 665                 670         


Ala His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Pro 
        675                 680                 685             


Glu Leu Leu Ala Val Met Thr Ala Met Gly Asn Ala Leu Ala Asn Ser 
    690                 695                 700                 


Val Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro Gly Pro Asp Ala 
705                 710                 715                 720 


Cys Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys 
                725                 730                 735     


Leu Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro Leu Gly Gln Gln 
            740                 745                 750         


Leu Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu Leu Val Met Leu 
        755                 760                 765             


Leu Ala His Gly Ser Lys Glu Glu Val Asn Glu Thr Tyr Gly Asp Gly 
    770                 775                 780                 


Asp Gly Arg Thr Ala Leu His Leu Ser Ser Ala Met Ala Asn Val Val 
785                 790                 795                 800 


Phe Thr Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Arg Ser Arg Asp 
                805                 810                 815     


Ala Arg Gly Leu Thr Pro Leu Ala Tyr Ala Arg Arg Ala Gly Ser Gln 
            820                 825                 830         


Glu Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro Gly Glu Gly Cys 
        835                 840                 845             


Gly Leu Ala Pro Thr Pro Asn Arg Glu Pro Ala Asn Gly Thr Asn Pro 
    850                 855                 860                 


Ser Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
865                 870                 875 


<210>  43
<211>  2715
<212>  DNA
<213>  Homo sapiens

<400>  43
atggcggaat catcggaatc cttcaccatg gcatccagcc cggcccagcg tcggcgaggc       60

aatgatcctc tcacctccag ccctggccga agctcccggc gtactgatgc cctcacctcc      120

agccctggcc gtgaccttcc accatttgag gatgagtccg aggggctcct aggcacagag      180

gggcccctgg aggaagaaga ggatggagag gagctcattg gagatggcat ggaaagggac      240

taccgcgcca tcccagagct ggacgcctat gaggccgagg gactggctct ggatgatgag      300

gacgtagagg agctgacggc cagtcagagg gaggcagcag agcgggccat gcggcagcgt      360

gaccgggagg ctggccgggg cctgggccgc atgcgccgtg ggctcctgta tgacagcgat      420

gaggaggacg aggagcgccc tgcccgcaag cgccgccagg tggagcgggc cacggaggac      480

ggcgaggagg acgaggagat gatcgagagc atcgagaacc tggaggatct caaaggccac      540

tctgtgcgcg agtgggtgag catggcgggc ccccggctgg agatccacca ccgcttcaag      600

aacttcctgc gcactcacgt cgacagccac ggccacaacg tcttcaagga gcgcatcagc      660

gacatgtgca aagagaaccg tgagagcctg gtggtgaact atgaggactt ggcagccagg      720

gagcacgtgc tggcctactt cctgcctgag gcaccggcgg agctgctgca gatctttgat      780

gaggctgccc tggaggtggt actggccatg taccccaagt acgaccgcat caccaaccac      840

atccatgtcc gcatctccca cctgcctctg gtggaggagc tgcgctcgct gaggcagctg      900

catctgaacc agctgatccg caccagtggg gtggtgacca gctgcactgg cgtcctgccc      960

cagctcagca tggtcaagta caactgcaac aagtgcaatt tcgtcctggg tcctttctgc     1020

cagtcccaga accaggaggt gaaaccaggc tcctgtcctg agtgccagtc ggccggcccc     1080

tttgaggtca acatggagga gaccatctat cagaactacc agcgtatccg aatccaggag     1140

agtccaggca aagtggcggc tggccggctg ccccgctcca aggacgccat tctcctcgca     1200

gatctggtgg acagctgcaa gccaggagac gagatagagc tgactggcat ctatcacaac     1260

aactatgatg gctccctcaa cactgccaat ggcttccctg tctttgccac tgtcatccta     1320

gccaaccacg tggccaagaa ggacaacaag gttgctgtag gggaactgac cgatgaagat     1380

gtgaagatga tcactagcct ctccaaggat cagcagatcg gagagaagat ctttgccagc     1440

attgctcctt ccatctatgg tcatgaagac atcaagagag gcctggctct ggccctgttc     1500

ggaggggagc ccaaaaaccc aggtggcaag cacaaggtac gtggtgatat caacgtgctc     1560

ttgtgcggag accctggcac agcgaagtcg cagtttctca agtatattga gaaagtgtcc     1620

agccgagcca tcttcaccac tggccagggg gcgtcggctg tgggcctcac ggcgtatgtc     1680

cagcggcacc ctgtcagcag ggagtggacc ttggaggctg gggccctggt tctggctgac     1740

cgaggagtgt gtctcattga tgaatttgac aagatgaatg accaggacag aaccagcatc     1800

catgaggcca tggagcaaca gagcatctcc atctcgaagg ctggcatcgt cacctccctg     1860

caggctcgct gcacggtcat tgctgccgcc aaccccatag gagggcgcta cgacccctcg     1920

ctgactttct ctgagaacgt ggacctcaca gagcccatca tctcacgctt tgacatcctg     1980

tgtgtggtga gggacaccgt ggacccagtc caggacgaga tgctggcccg cttcgtggtg     2040

ggcagccacg tcagacacca ccccagcaac aaggaggagg aggggctggc caatggcagc     2100

gctgctgagc ccgccatgcc caacacgtat ggcgtggagc ccctgcccca ggaggtcctg     2160

aagaagtaca tcatctacgc caaggagagg gtccacccga agctcaacca gatggaccag     2220

gacaaggtgg ccaagatgta cagtgacctg aggaaagaat ctatggcgac aggcagcatc     2280

cccattacgg tgcggcacat cgagtccatg atccgcatgg cggaggccca cgcgcgcatc     2340

catctgcggg actatgtgat cgaagacgac gtcaacatgg ccatccgcgt gatgctggag     2400

agcttcatag acacacagaa gttcagcgtc atgcgcagca tgcgcaagac ttttgcccgc     2460

tacctttcat tccggcgtga caacaatgag ctgttgctct tcatactgaa gcagttagtg     2520

gcagagcagg tgacatatca gcgcaaccgc tttggggccc agcaggacac tattgaggtc     2580

cctgagaagg acttggtgga taaggctcgt cagatcaaca tccacaacct ctctgcattt     2640

tatgacagtg agctcttcag gatgaacaag ttcagccacg acctgaaaag gaaaatgatc     2700

ctgcagcagt tctga                                                      2715


<210>  44
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Ser Ser 
            20                  25                  30          


Arg Arg Thr Asp Ala Leu Thr Ser Ser Pro Gly Arg Asp Leu Pro Pro 
        35                  40                  45              


Phe Glu Asp Glu Ser Glu Gly Leu Leu Gly Thr Glu Gly Pro Leu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Glu Glu Leu Ile Gly Asp Gly Met Glu Arg Asp 
65                  70                  75                  80  


Tyr Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala 
                85                  90                  95      


Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala 
            100                 105                 110         


Ala Glu Arg Ala Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu 
        115                 120                 125             


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
    130                 135                 140                 


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
145                 150                 155                 160 


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
                165                 170                 175     


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
            180                 185                 190         


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
        195                 200                 205             


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
    210                 215                 220                 


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
225                 230                 235                 240 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
                245                 250                 255     


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
            260                 265                 270         


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
        275                 280                 285             


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
    290                 295                 300                 


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
305                 310                 315                 320 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
                325                 330                 335     


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
            340                 345                 350         


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
        355                 360                 365             


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
    370                 375                 380                 


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
385                 390                 395                 400 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
                405                 410                 415     


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
            420                 425                 430         


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
        435                 440                 445             


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
    450                 455                 460                 


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
465                 470                 475                 480 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
                485                 490                 495     


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
            500                 505                 510         


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
        515                 520                 525             


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
    530                 535                 540                 


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
545                 550                 555                 560 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
                565                 570                 575     


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
            580                 585                 590         


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
        595                 600                 605             


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
    610                 615                 620                 


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
625                 630                 635                 640 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
                645                 650                 655     


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
            660                 665                 670         


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
        675                 680                 685             


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
    690                 695                 700                 


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
705                 710                 715                 720 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
                725                 730                 735     


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
            740                 745                 750         


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
        755                 760                 765             


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
    770                 775                 780                 


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
785                 790                 795                 800 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
                805                 810                 815     


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
            820                 825                 830         


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
        835                 840                 845             


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
    850                 855                 860                 


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
865                 870                 875                 880 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
                885                 890                 895     


Arg Lys Met Ile Leu Gln Gln Phe 
            900                 


<210>  45
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  45
atgaaaataa gtatgataaa ttataagtca ctattggcac tgttgtttat attagcctcc       60

tggatcattt ttacagtttt ccagaactcc acaaaggttt ggtctgctct aaacttatcc      120

atctccctcc attactggaa caactccaca aagtccttat tccctaaaac accactgata      180

tcattaaagc cactaacaga gactgaactc agaataaagg aaatcataga gaaactagat      240

cagcagatcc cacccagacc tttcacccac gtgaacacca ccaccagcgc cacacatagc      300

acagccacca tcctcaaccc tcgagatacg tactgcaggg gagaccagct gcacatcctg      360

ctggaggtga gggaccactt gggacgcagg aagcaatatg gcggggattt cctgagggcc      420

aggatgtctt ccccagcgct gatggcaggt gcttcaggaa aggtgactga cttcaacaac      480

ggcacctacc tggtcagctt cactctgttc tgggagggcc aggtctctct gtctctgctg      540

ctcatccacc ccagtgaagg ggtgtcagct ctctggagtg caaggaacca aggctatgac      600

agggtgatct tcactggcca gtttgtcaat ggcacttccc aagtccactc tgaatgtggc      660

ctgatcctaa acacaaatgc tgaattgtgc cagtacctgg acaacagaga ccaagaaggc      720

ttctactgtg tgaggcctca acacatgccc tgtgctgcac tcactcacat gtattctaag      780

aacaagaaag tttcttatct tagcaaacaa gaaaagagcc tctttgaaag gtcaaatgtg      840

ggtgtagaga ttatggaaaa attcaataca attagtgtct ccaaatgcaa caaagaaaca      900

gttgcaatga aagagaaatg caagtttgga atgacatcca caatccccag tgggcatgtc      960

tggagaaaca catggaatcc tgtctcctgt agtttggcta cagtcaaaat gaaggaatgc     1020

ctgagaggaa aactcatata cctaatggga gattccacga tccgccagtg gatggaatac     1080

ttcaaagcca gtatcaacac actgaagtca gtggatctgc atgaatctgg aaaattgcaa     1140

caccagcttg ctgtggattt ggataggaac atcaacatcc agtggcaaaa atattgttat     1200

cccttgatag gatcaatgac ctattcagtc aaagagatgg agtacctcac ccgggccatt     1260

gacagaactg gaggagaaaa aaatactgtc attgttattt ccctgggcca gcatttcaga     1320

ccctttccca ttgatgtttt tatccgaagg gccctcaatg tccacaaagc cattcagcat     1380

cttcttctga gaagcccaga cactatggtt atcatcaaaa cagaaaacat cagggagatg     1440

tacaatgatg cagaaagatt tagtgacttt catggttaca ttcaatatct catcataaag     1500

gacattttcc aggatctcag tgtgagtatc attgatgcct gggatataac aattgcatat     1560

ggcacaaata atgtacaccc acctcaacat gtagtcggaa atcagattaa tatattatta     1620

aactatattt gttaa                                                      1635


<210>  46
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Ile Ser Met Ile Asn Tyr Lys Ser Leu Leu Ala Leu Leu Phe 
1               5                   10                  15      


Ile Leu Ala Ser Trp Ile Ile Phe Thr Val Phe Gln Asn Ser Thr Lys 
            20                  25                  30          


Val Trp Ser Ala Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn 
        35                  40                  45              


Ser Thr Lys Ser Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro 
    50                  55                  60                  


Leu Thr Glu Thr Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp 
65                  70                  75                  80  


Gln Gln Ile Pro Pro Arg Pro Phe Thr His Val Asn Thr Thr Thr Ser 
                85                  90                  95      


Ala Thr His Ser Thr Ala Thr Ile Leu Asn Pro Arg Asp Thr Tyr Cys 
            100                 105                 110         


Arg Gly Asp Gln Leu His Ile Leu Leu Glu Val Arg Asp His Leu Gly 
        115                 120                 125             


Arg Arg Lys Gln Tyr Gly Gly Asp Phe Leu Arg Ala Arg Met Ser Ser 
    130                 135                 140                 


Pro Ala Leu Met Ala Gly Ala Ser Gly Lys Val Thr Asp Phe Asn Asn 
145                 150                 155                 160 


Gly Thr Tyr Leu Val Ser Phe Thr Leu Phe Trp Glu Gly Gln Val Ser 
                165                 170                 175     


Leu Ser Leu Leu Leu Ile His Pro Ser Glu Gly Val Ser Ala Leu Trp 
            180                 185                 190         


Ser Ala Arg Asn Gln Gly Tyr Asp Arg Val Ile Phe Thr Gly Gln Phe 
        195                 200                 205             


Val Asn Gly Thr Ser Gln Val His Ser Glu Cys Gly Leu Ile Leu Asn 
    210                 215                 220                 


Thr Asn Ala Glu Leu Cys Gln Tyr Leu Asp Asn Arg Asp Gln Glu Gly 
225                 230                 235                 240 


Phe Tyr Cys Val Arg Pro Gln His Met Pro Cys Ala Ala Leu Thr His 
                245                 250                 255     


Met Tyr Ser Lys Asn Lys Lys Val Ser Tyr Leu Ser Lys Gln Glu Lys 
            260                 265                 270         


Ser Leu Phe Glu Arg Ser Asn Val Gly Val Glu Ile Met Glu Lys Phe 
        275                 280                 285             


Asn Thr Ile Ser Val Ser Lys Cys Asn Lys Glu Thr Val Ala Met Lys 
    290                 295                 300                 


Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro Ser Gly His Val 
305                 310                 315                 320 


Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu Ala Thr Val Lys 
                325                 330                 335     


Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu Met Gly Asp Ser 
            340                 345                 350         


Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser Ile Asn Thr Leu 
        355                 360                 365             


Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln His Gln Leu Ala 
    370                 375                 380                 


Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln Lys Tyr Cys Tyr 
385                 390                 395                 400 


Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu Met Glu Tyr Leu 
                405                 410                 415     


Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn Thr Val Ile Val 
            420                 425                 430         


Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile Asp Val Phe Ile 
        435                 440                 445             


Arg Arg Ala Leu Asn Val His Lys Ala Ile Gln His Leu Leu Leu Arg 
    450                 455                 460                 


Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn Ile Arg Glu Met 
465                 470                 475                 480 


Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly Tyr Ile Gln Tyr 
                485                 490                 495     


Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val Ser Ile Ile Asp 
            500                 505                 510         


Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn Val His Pro Pro 
        515                 520                 525             


Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu Asn Tyr Ile Cys 
    530                 535                 540                 


<210>  47
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  47
atgagtgggg ggcgggctcc cgcggtcctg ctcggcggag tggcctctct gctcctgtct       60

tttgtttgga tgccggcgct gctgcctgtg gcctcccgcc ttttgttgct accccgagtc      120

ttgctgacca tggcctctgg aagccctccg acccagccct cgccggcctc ggattccggc      180

tctggctacg ttccgggctc ggtctctgca gcctttgtta cttgccccaa cgagaaggtc      240

gccaaggaga tcgccagggc cgtggtggag aagcgcctag cagcctgcgt caacctcatc      300

cctcagatta catccatcta tgagtggaaa gggaagatcg aggaagacag tgaggtgctg      360

atgatgatta aaacccaaag ttccttggtc ccagctttga cagattttgt tcgttctgtg      420

cacccttacg aagtggccga ggtaattgca ttgcctgtgg aacaggggaa ctttccgtac      480

ctgcagtggg tgcgccaggt cacagagtca gtttctgact ctatcacagt cctgccatga      540


<210>  48
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  49
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  49
atgaagaggg tcctggtact actgcttgct gtggcatttg gacatgcttt agagagaggc       60

cgggattatg aaaagaataa agtctgcaag gaattctccc atctgggaaa ggaggacttc      120

acatctctgt cactagtcct gtacagtaga aaatttccca gtggcacgtt tgaacaggtc      180

agccaacttg tgaaggaagt tgtctccttg accgaagcct gctgtgcgga aggggctgac      240

cctgactgct atgacaccag gacctcagca ctgtctgcca agtcctgtga aagtaattct      300

ccattccccg ttcacccagg cactgctgag tgctgcacca aagagggcct ggaacgaaag      360

ctctgcatgg ctgctctgaa acaccagcca caggaattcc ctacctacgt ggaacccaca      420

aatgatgaaa tctgtgaggc gttcaggaaa gatccaaagg aatatgctaa tcaatttatg      480

tgggaatatt ccactaatta cggacaagct cctctgtcac ttttagtcag ttacaccaag      540

agttatcttt ctatggtagg gtcctgctgt acctctgcaa gcccaactgt atgctttttg      600

aaagagagac tccagcttaa acatttatca cttctcacca ctctgtcaaa tagagtctgc      660

tcacaatatg ctgcttatgg ggagaagaaa tcaaggctca gcaatctcat aaagttagcc      720

caaaaagtgc ctactgctga tctggaggat gttttgccac tagctgaaga tattactaac      780

atcctctcca aatgctgtga gtctgcctct gaagattgca tggccaaaga gctgcctgaa      840

cacacagtaa aactctgtga caatttatcc acaaagaatt ctaagtttga agactgttgt      900

caagaaaaaa cagccatgga cgtttttgtg tgcacttact tcatgccagc tgcccaactc      960

cccgagcttc cagatgtaga gttgcccaca aacaaagatg tgtgtgatcc aggaaacacc     1020

aaagtcatgg ataagtatac atttgaacta agcagaagga ctcatcttcc ggaagtattc     1080

ctcagtaagg tacttgagcc aaccctaaaa agccttggtg aatgctgtga tgttgaagac     1140

tcaactacct gttttaatgc taagggccct ctactaaaga aggaactatc ttctttcatt     1200

gacaagggac aagaactatg tgcagattat tcagaaaata catttactga gtacaagaaa     1260

aaactggcag agcgactaaa agcaaaattg cctgatgcca cacccacgga actggcaaag     1320

ctggttaaca agcactcaga ctttgcctcc aactgctgtt ccataaactc acctcctctt     1380

tactgtgatt cagagattga tgctgaattg aagaatatcc tgtag                     1425


<210>  50
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  51
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  51
atgggtgagt tcaacgagaa gaagacaaca tgtggcaccg tttgcctcaa gtacctgctg       60

tttacctaca attgctgctt ctggctggct ggcctggctg tcatggcagt gggcatctgg      120

acgctggccc tcaagagtga ctacatcagc ctgctggcct caggcaccta cctggccaca      180

gcctacatcc tggtggtggc gggcactgtc gtcatggtga ctggggtctt gggctgctgc      240

gccaccttca aggagcgtcg gaacctgctg cgcctgtact tcatcctgct cctcatcatc      300

tttctgctgg agatcatcgc tggtatcctc gcctacgcct actaccagca gctgaacacg      360

gagctcaagg agaacctgaa ggacaccatg accaagcgct accaccagcc gggccatgag      420

gctgtgacca gcgctgtgga ccagctgcag caggagttcc actgctgtgg cagcaacaac      480

tcacaggact ggcgagacag tgagtggatc cgctcacagg aggccggtgg ccgtgtggtc      540

ccagacagct gctgcaagac ggtggtggct ctttgtgggc agcgagacca tgcctccaac      600

atctacaagg tggagggcgg ctgcatcacc aagttggaga ccttcatcca ggagcacctg      660

agggtcattg gggctgtggg gatcggcatt gcctgtgtgc aggtctttgg catgatcttc      720

acgtgctgcc tgtacaggag tctcaagctg gagcactact ga                         762


<210>  52
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  53
<211>  2702
<212>  DNA
<213>  Homo sapiens

<400>  53
gctttgaggt gcagagcgcc gtgcgcctgg tgcacagctg ggcgctggcc gagagctgcg       60

cgctggcagc cgtcaaggcg ctgtccctgt acagcatgag cgccggcgac gggctgcgcc      120

ggggcaagtc cgcgcgctgc ggcctcacct tctcagtggg tcgctttttc cgctggatgg      180

tggacacccg aatctccgtg cgcatccacg agtacgcagc catctccctc accgcctgca      240

tggagaacct ggtggaggag atccgggcca gggtgatggc cagccacagc cctgatggcg      300

gaggggccgg aggcggggag gtgtctgctg aggccctgga gatggtcatc aacaacgacg      360

ccgagctctg gggcgtcttg cagccctatg agcatctcat ctgcggcaag aacgccaatg      420

gtgtcctctc cctccccgca tacttcagcc cctacaacgg cgggtccctg ggccatgacg      480

agcgagccga tgcctatgcc cagctggagc tccgaaccct ggagcagtcc ctcctggcca      540

cctgcgtggg cagcatctcg gagctgagtg acttggtctc ccgtgccatg caccacatgc      600

aggggcgtca ccccctgtgc ccgggtgcca gccctgcccg ccaggcccgc cagccgccac      660

agcccatcac ttggtccccc gacgccctcc acacgctcta ctactttctg cggtgtccac      720

agatggagtc catggagaac cccaacctgg accccccgag aatgaccttg aacaatgaac      780

ggcccttcat gctgctgccg cccctcatgg agtggatgcg cgtggccatc acctacgcag      840

agcaccgccg cagcctcacc gtggacagcg gcgacatccg gcaggcagcc cggctgctgc      900

tgcctggtct ggactgtgaa cctcggcagc tcaaacccga acactgtttc agttccttcc      960

ggaggctgga tgcccgagca gctactgaaa aattcaacca ggacctgggt ttccgcatgc     1020

tcaactgtgg gaggacggac ctcatcaacc aagccatcga ggccttgggt ccggatgggg     1080

ttaacaccat ggatgaccag ggtatgacgc cactgatgta cgcctgcgct gctggggacg     1140

aagcgatggt ccagatgttg attgatgctg gggcaaactt ggacatccag gttccaagca     1200

actcccccag gcacccttcc atccaccccg acagccggca ctggacctca ctgacattcg     1260

ctgtgctgca tggacacatc tctgtggtcc agttgctgct ggatgctggt gcccatgtcg     1320

agggctcggc agtgaacggc ggcgaggaca gctatgcgga gacgcccctg cagctggcct     1380

ctgcggcagg gaactatgag ctggtcagtt tgttgctgag ccgaggcgcc gaccccctcc     1440

tcagcatgct ggaggcccac ggcatgggct cctccctcca cgaggacatg aactgcttca     1500

gccactcagc tgcccacggc cacaggaacg tcctgaggaa gctcctgacg cagccacagc     1560

aggctaaagc ggacgtgctg tccctggagg agatcctggc cgagggtgtg gaggaaagtg     1620

atgcgtcgag ccagggcagt ggcagcgagg ggcccgtgcg gctgagccgg acccgcacca     1680

aggccctaca ggaggccatg tactacagcg ctgagcacgg ctacgtggac atcaccatgg     1740

agctgagggc actgggagtc ccctggaagc tgcacatctg gatcgagtct ctgaggacct     1800

cgttctcgca gtcgcggtac tcggtggtgc agagcctcct gcgggacttc agctccatca     1860

gagaggagga gtacaacgag gagctggtga ccgagggctt gcagctcatg ttcgacatcc     1920

tcaagaccag caaaaacgac tccgtcatcc agcaactggc taccatcttc acccactgct     1980

atggcagcag tcccatcccc agcatcccag agatccggaa gaccctgccg gccaggctag     2040

atccacactt tttgaacaat aaggagatgt cagatgtgac cttcctggtg gaaggaaagc     2100

tgttttatgc acataaagtc ctgctggtga cagcttctaa caggttcaag acactaatga     2160

ccaataaatc agaacaggat ggggacagca gcaagaccat cgagatcagc gacatgaagt     2220

accacatttt tcagatgatg atgcagtatc tgtactacgg aggaacagaa tccatggaga     2280

tccccaccac tgacatcctg gagctgctgt cagctgccag cctgttccag ctggatgccc     2340

tgcagaggca ctgcgagatc ctgtgctccc agaccctcag catggagagt gccgtgaaca     2400

cctacaaata tgccaagatc cacaatgccc cagaactggc cctgttctgt gagggcttct     2460

tcctcaagca catgaaggcc ctactggagc aggatgcctt ccggcagctc atctacggcc     2520

gcagcagcaa agtgcagggc ctggatccac tgcaggacct gcagaacacc ctggcagagc     2580

gcgtgcactc tgtctacatc acctcccggg tgtgaggcag ggggcggagg ctgccgaggc     2640

cagggcctgt ggaggtgcca gggcccacca tgtcggggta tggttgtagg ccctcttgga     2700

gc                                                                    2702


<210>  54
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Ala Gly Asp Gly Leu Arg Arg Gly Lys Ser Ala Arg Cys Gly 
1               5                   10                  15      


Leu Thr Phe Ser Val Gly Arg Phe Phe Arg Trp Met Val Asp Thr Arg 
            20                  25                  30          


Ile Ser Val Arg Ile His Glu Tyr Ala Ala Ile Ser Leu Thr Ala Cys 
        35                  40                  45              


Met Glu Asn Leu Val Glu Glu Ile Arg Ala Arg Val Met Ala Ser His 
    50                  55                  60                  


Ser Pro Asp Gly Gly Gly Ala Gly Gly Gly Glu Val Ser Ala Glu Ala 
65                  70                  75                  80  


Leu Glu Met Val Ile Asn Asn Asp Ala Glu Leu Trp Gly Val Leu Gln 
                85                  90                  95      


Pro Tyr Glu His Leu Ile Cys Gly Lys Asn Ala Asn Gly Val Leu Ser 
            100                 105                 110         


Leu Pro Ala Tyr Phe Ser Pro Tyr Asn Gly Gly Ser Leu Gly His Asp 
        115                 120                 125             


Glu Arg Ala Asp Ala Tyr Ala Gln Leu Glu Leu Arg Thr Leu Glu Gln 
    130                 135                 140                 


Ser Leu Leu Ala Thr Cys Val Gly Ser Ile Ser Glu Leu Ser Asp Leu 
145                 150                 155                 160 


Val Ser Arg Ala Met His His Met Gln Gly Arg His Pro Leu Cys Pro 
                165                 170                 175     


Gly Ala Ser Pro Ala Arg Gln Ala Arg Gln Pro Pro Gln Pro Ile Thr 
            180                 185                 190         


Trp Ser Pro Asp Ala Leu His Thr Leu Tyr Tyr Phe Leu Arg Cys Pro 
        195                 200                 205             


Gln Met Glu Ser Met Glu Asn Pro Asn Leu Asp Pro Pro Arg Met Thr 
    210                 215                 220                 


Leu Asn Asn Glu Arg Pro Phe Met Leu Leu Pro Pro Leu Met Glu Trp 
225                 230                 235                 240 


Met Arg Val Ala Ile Thr Tyr Ala Glu His Arg Arg Ser Leu Thr Val 
                245                 250                 255     


Asp Ser Gly Asp Ile Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Leu 
            260                 265                 270         


Asp Cys Glu Pro Arg Gln Leu Lys Pro Glu His Cys Phe Ser Ser Phe 
        275                 280                 285             


Arg Arg Leu Asp Ala Arg Ala Ala Thr Glu Lys Phe Asn Gln Asp Leu 
    290                 295                 300                 


Gly Phe Arg Met Leu Asn Cys Gly Arg Thr Asp Leu Ile Asn Gln Ala 
305                 310                 315                 320 


Ile Glu Ala Leu Gly Pro Asp Gly Val Asn Thr Met Asp Asp Gln Gly 
                325                 330                 335     


Met Thr Pro Leu Met Tyr Ala Cys Ala Ala Gly Asp Glu Ala Met Val 
            340                 345                 350         


Gln Met Leu Ile Asp Ala Gly Ala Asn Leu Asp Ile Gln Val Pro Ser 
        355                 360                 365             


Asn Ser Pro Arg His Pro Ser Ile His Pro Asp Ser Arg His Trp Thr 
    370                 375                 380                 


Ser Leu Thr Phe Ala Val Leu His Gly His Ile Ser Val Val Gln Leu 
385                 390                 395                 400 


Leu Leu Asp Ala Gly Ala His Val Glu Gly Ser Ala Val Asn Gly Gly 
                405                 410                 415     


Glu Asp Ser Tyr Ala Glu Thr Pro Leu Gln Leu Ala Ser Ala Ala Gly 
            420                 425                 430         


Asn Tyr Glu Leu Val Ser Leu Leu Leu Ser Arg Gly Ala Asp Pro Leu 
        435                 440                 445             


Leu Ser Met Leu Glu Ala His Gly Met Gly Ser Ser Leu His Glu Asp 
    450                 455                 460                 


Met Asn Cys Phe Ser His Ser Ala Ala His Gly His Arg Asn Val Leu 
465                 470                 475                 480 


Arg Lys Leu Leu Thr Gln Pro Gln Gln Ala Lys Ala Asp Val Leu Ser 
                485                 490                 495     


Leu Glu Glu Ile Leu Ala Glu Gly Val Glu Glu Ser Asp Ala Ser Ser 
            500                 505                 510         


Gln Gly Ser Gly Ser Glu Gly Pro Val Arg Leu Ser Arg Thr Arg Thr 
        515                 520                 525             


Lys Ala Leu Gln Glu Ala Met Tyr Tyr Ser Ala Glu His Gly Tyr Val 
    530                 535                 540                 


Asp Ile Thr Met Glu Leu Arg Ala Leu Gly Val Pro Trp Lys Leu His 
545                 550                 555                 560 


Ile Trp Ile Glu Ser Leu Arg Thr Ser Phe Ser Gln Ser Arg Tyr Ser 
                565                 570                 575     


Val Val Gln Ser Leu Leu Arg Asp Phe Ser Ser Ile Arg Glu Glu Glu 
            580                 585                 590         


Tyr Asn Glu Glu Leu Val Thr Glu Gly Leu Gln Leu Met Phe Asp Ile 
        595                 600                 605             


Leu Lys Thr Ser Lys Asn Asp Ser Val Ile Gln Gln Leu Ala Thr Ile 
    610                 615                 620                 


Phe Thr His Cys Tyr Gly Ser Ser Pro Ile Pro Ser Ile Pro Glu Ile 
625                 630                 635                 640 


Arg Lys Thr Leu Pro Ala Arg Leu Asp Pro His Phe Leu Asn Asn Lys 
                645                 650                 655     


Glu Met Ser Asp Val Thr Phe Leu Val Glu Gly Lys Leu Phe Tyr Ala 
            660                 665                 670         


His Lys Val Leu Leu Val Thr Ala Ser Asn Arg Phe Lys Thr Leu Met 
        675                 680                 685             


Thr Asn Lys Ser Glu Gln Asp Gly Asp Ser Ser Lys Thr Ile Glu Ile 
    690                 695                 700                 


Ser Asp Met Lys Tyr His Ile Phe Gln Met Met Met Gln Tyr Leu Tyr 
705                 710                 715                 720 


Tyr Gly Gly Thr Glu Ser Met Glu Ile Pro Thr Thr Asp Ile Leu Glu 
                725                 730                 735     


Leu Leu Ser Ala Ala Ser Leu Phe Gln Leu Asp Ala Leu Gln Arg His 
            740                 745                 750         


Cys Glu Ile Leu Cys Ser Gln Thr Leu Ser Met Glu Ser Ala Val Asn 
        755                 760                 765             


Thr Tyr Lys Tyr Ala Lys Ile His Asn Ala Pro Glu Leu Ala Leu Phe 
    770                 775                 780                 


Cys Glu Gly Phe Phe Leu Lys His Met Lys Ala Leu Leu Glu Gln Asp 
785                 790                 795                 800 


Ala Phe Arg Gln Leu Ile Tyr Gly Arg Ser Ser Lys Val Gln Gly Leu 
                805                 810                 815     


Asp Pro Leu Gln Asp Leu Gln Asn Thr Leu Ala Glu Arg Val His Ser 
            820                 825                 830         


Val Tyr Ile Thr Ser Arg Val 
        835                 


<210>  55
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  55
atgcgcctct cctcctcccc acctcgtggc ccgcagcagc tctccagctt tggctccgtg       60

gactggctct cccagagcag ctgctcaggg ccgacccaca cccccaggcc tgccgacttc      120

tccctgggga gcctccctgg cccaggccag acatccggcg cccgggagcc ccctcaggcc      180

gtcagcatca aggaggccgc cgggtcctca aatctgcctg cgccggagag gaccatggcc      240

gggttgagta aggagccaaa taccttgcgg gccccccgtg tccgcacagc cttcaccatg      300

gagcaggtcc gcaccttgga gggcgtcttc cagcaccacc agtacctgag ccctctggag      360

cggaagaggc tggccaggga gatgcagctc tcagaggtcc agataaaaac ctggtttcag      420

aatcgccgca tgaaacacaa acggcaaatg caggaccccc agctgcacag ccccttctcg      480

gggtctctcc atgcgccccc agctttctac tcaacgtctt ctggccttgc caatggcctg      540

cagctgctgt gcccttgggc acccctgtcc gggccccagg ctctgatgct gccccctggc      600

tccttctggg gtctctgcca agtggcacaa gaggccctgg catctgcggg agcttcctgc      660

tgcgggcagc ctctggcgtc ccacccccct accccaggcc ggccttcgct gggaccagcc      720

ctgtccacgg ggccccgggg cctgtgtgct atgccacaga cgggggatgc attttga         777


<210>  56
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln Leu Ser Ser 
1               5                   10                  15      


Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser Gly Pro Thr 
            20                  25                  30          


His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu Pro Gly Pro 
        35                  40                  45              


Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val Ser Ile Lys 
    50                  55                  60                  


Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg Thr Met Ala 
65                  70                  75                  80  


Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg Val Arg Thr 
                85                  90                  95      


Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val Phe Gln His 
            100                 105                 110         


His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala Arg Glu Met 
        115                 120                 125             


Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn Arg Arg Met 
    130                 135                 140                 


Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser Pro Phe Ser 
145                 150                 155                 160 


Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser Ser Gly Leu 
                165                 170                 175     


Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu Ser Gly Pro 
            180                 185                 190         


Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu Cys Gln Val 
        195                 200                 205             


Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys Gly Gln Pro 
    210                 215                 220                 


Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu Gly Pro Ala 
225                 230                 235                 240 


Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln Thr Gly Asp 
                245                 250                 255     


Ala Phe 
        


<210>  57
<211>  10002
<212>  DNA
<213>  Homo sapiens

<400>  57
atggcggcgg ccgcgcggcc tcggggtcgg gcactggggc cagtactgcc gccgacgccg       60

ctgctcctgc tggtactgcg ggtgctgcca gcctgcgggg cgaccgctcg ggatcccggg      120

gccgcggccg ggctcagcct tcacccgact tacttcaacc tggccgaggc ggcgaggatt      180

tgggccaccg ccacctgcgg ggagagggga cccggcgagg ggaggcccca gcccgagctc      240

tactgcaagt tggtcggggg ccccaccgcc ccaggcagcg gccacaccat ccagggccag      300

ttctgtgact attgcaattc tgaagacccc aggaaagcac atcctgtcac caatgccatc      360

gatggatctg aacgttggtg gcaaagccct cccctgtcct caggcacaca gtacaacaga      420

gtcaacctca ccttggatct ggggcagctc ttccatgtgg cctatatttt aatcaaattt      480

gcaaattctc ctcgccctga tctttgggtc ttggaaagat ctgtagactt tggaagcacc      540

tactcaccat ggcaatattt tgctcattct aaagtagact gtttaaaaga atttgggcgg      600

gaggcaaata tggctgtcac ccgggatgat gatgtacttt gtgttactga atattcccgt      660

attgtacctt tggaaaatgg tgaggttgtg gtgtccttga taaacggtcg tccaggtgca      720

aaaaatttta ctttctctca caccctgagg gagtttacca aggcaacaaa catccgcttg      780

cgttttctta gaaccaatac gcttcttgga cacctcatct ccaaagccca gcgagatcca      840

actgtcactc ggcggtatta ttacagcata aaggacatca gcattggtgg gcagtgtgtt      900

tgcaatggcc atgctgaagt gtgcaatata aacaatcctg aaaaactgtt tcggtgtgaa      960

tgccagcacc acacctgtgg ggagacgtgt gatcgctgct gcacagggta caatcagagg     1020

cgctggcggc ccgccgcttg ggagcagagc cacgagtgtg aagcatgcaa ctgccacggc     1080

catgccagca actgttacta tgatccagat gttgagcggc agcaggcaag cttgaatacc     1140

cagggcatct atgctggtgg aggggtctgc attaactgtc agcacaacac agctggagta     1200

aactgtgaac agtgtgctaa gggctattac cgcccttatg gggttccagt ggatgcccct     1260

gatggctgca tcccctgcag ctgtgaccct gagcatgcgg atggctgtga acagggttca     1320

ggccgctgtc actgcaagcc aaatttccac ggagacaact gtgagaagtg tgcaattgga     1380

tactacaatt tcccattttg cttgagaatt cccatttttc ctgtttctac accaagttca     1440

gaagatccag tagctggaga tataaaaggg tgtgactgta atctggaagg tgttctccct     1500

gaaatatgtg atgcccacgg acggtgcctg tgccgccctg gggttgaggg ccctcgatgt     1560

gatacctgcc gctctggttt ctactcattc cctatttgcc aagcctgctg gtgttcagcc     1620

cttggatcct accagatgcc ctgcagctca gtgactggac agtgtgaatg tcggccagga     1680

gttacaggac agcggtgtga caggtgtctc tcaggagctt atgatttccc ccactgccaa     1740

ggttccagca gtgcttgtga cccagctggt accatcaact ccaatttggg gtattgccaa     1800

tgcaagcttc atgttgaagg tcctacttgt agccgctgca aactgttata ttggaatctg     1860

gacaaagaaa accccagtgg atgttcagaa tgcaagtgcc ataaggcggg aacagtgagt     1920

ggaactggag agtgtaggca gggagatggt gactgtcact gcaagtccca tgtgggtggc     1980

gattcctgcg acacctgtga agatggatat tttgctttgg aaaagagcaa ttactttggg     2040

tgtcaagggt gtcagtgtga cattggtggg gcattgtcct ccatgtgcag tgggccctcg     2100

ggagtgtgcc agtgccgaga gcatgtcgtg ggaaaggtgt gccagcggcc tgaaaacaac     2160

tactatttcc cagatttgca tcatatgaag tatgagattg aagacggcag cacacctaat     2220

gggagagacc ttcgatttgg atttgatccg ctggcatttc ctgagtttag ctggagagga     2280

tatgcccaaa tgacctcagt acagaatgat gtaagaataa cattgaatgt agggaagtca     2340

agtggctcct tgtttcgtgt tattctgaga tacgttaacc ctggaactga agcagtatct     2400

ggccatataa ctatttatcc atcctggggt gctgctcaaa gcaaagagat catcttcctg     2460

ccgagtaagg agccagcctt tgtcactgtc cctggaaatg gttttgcaga cccattttca     2520

atcacaccag gaatatgggt tgcttgtatt aaggcagaag gagtccttct ggattacctg     2580

gtgctgctcc ccagggacta ctatgaagcc tctgtactgc agctgccagt cacagaacca     2640

tgtgcctacg caggacctcc ccaagaaaat tgcttactct accagcattt gccagtgacc     2700

agattcccct gtaccctggc ttgtgaggcc agacacttcc tgcttgatgg ggagccaaga     2760

cccgtggcag tgaggcagcc cacacctgca caccctgtca tggtggacct cagcgggaga     2820

gaggtggaat tgcatctgcg gctgcgcatc ccacaggttg gccactacgt ggttgtggtc     2880

gagtattcca cggaggcagc tcagctgttt gtggttgatg tgaatgtgaa gagctccggg     2940

tctgttctgg caggccaggt gaacatttac agctgcaact acagtgttct ctgccggagt     3000

gctgtgattg atcacatgag ccgcatcgcc atgtatgagc tattggcaga tgcagacatt     3060

cagctcaagg gacacatggc ccgattcctt ctgcatcaag tttgtatcat acctattgaa     3120

gaattctcag ctgagtatgt gagaccacaa gtccactgca ttgccagtta tgggcgattt     3180

gtcaatcaaa gtgccacctg tgtctccttg gcccatgaaa ctcctccaac agcattaatt     3240

ttggatgttc taagtggcag gcctttccct cacctgcccc agcagtcgtc accttctgtt     3300

gatgttcttc ctggggtcac cttgaaggca ccgcagaatc aagtgaccct gagaggacgt     3360

gtaccacacc tgggccgata cgtctttgtc atccattttt accaagcagc gcacccgacg     3420

tttcccgcgc aggtgtcggt ggatggcggg tggccacggg caggctcctt ccatgcctct     3480

ttttgccccc atgtgcttgg ctgccgggat caagtgattg ccgaaggcca gattgagttt     3540

gacatctcag agcctgaagt ggccgcaact gtgaaggttc cagaaggaaa gtccttggtt     3600

ttggtccgtg ttctagtggt gcctgcagaa aactatgact accaaatact tcacaaaaaa     3660

tccatggaca agtcactcga gtttatcacc aattgtggaa aaaacagctt ttaccttgac     3720

ccccagacag cctccagatt ctgtaagaat tccgccaggt ccctggtggc cttttaccac     3780

aagggcgccc tgccttgtga gtgccacccc actggggcca ccggccctca ctgcagccct     3840

gagggtgggc agtgcccatg ccagcccaac gtcatcgggc ggcagtgcac ccgctgtgca     3900

acaggccact acggattccc acgctgcaag ccgtgcagct gtggtcggcg cctttgtgaa     3960

gagatgacgg ggcagtgccg ctgccctccc cgcacggtca ggccccagtg tgaggtgtgt     4020

gagacacact cattcagctt ccaccccatg gccggctgcg aaggctgcaa ctgttccagg     4080

aggggcacca tcgaggctgc catgccggag tgtgaccggg acagcgggca gtgcagatgc     4140

aagcccagaa tcacagggcg gcagtgtgac cgatgtgctt ccgggtttta ccgctttcct     4200

gagtgtgttc cctgcaattg caacagagat gggactgagc caggagtgtg tgacccaggg     4260

accggggctt gcctctgcaa ggaaaatgta gaaggcacag agtgtaatgt gtgtcgagaa     4320

ggctcattcc atttggaccc agccaatctc aagggttgta ccagctgttt ctgttttgga     4380

gtaaataatc aatgtcacag ctcacataag cgaaggacta agtttgtgga tatgctgggc     4440

tggcacctgg agacagcaga cagagtggac atccctgtct ctttcaaccc aggcagcaac     4500

agtatggtgg cggatctcca ggagctgccc gcaaccatcc acagcgcgtc ctgggtcgca     4560

cccacctcct acctggggga caaggtttct tcatatggtg gttacctcac ttaccaagcc     4620

aagtcctttg gcttgcctgg cgacatggtt cttctggaaa agaagccgga tgtacagctc     4680

actggtcagc acatgtccat catctatgag gagacaaaca ccccacggcc agaccggctg     4740

catcatggac gagtgcacgt ggtcgaggga aacttcagac atgccagcag ccgtgcccca     4800

gtgtctaggg aggagctgat gacagtgctg tctagactgg cagatgtgcg catccaaggc     4860

ctctacttca cagagactca aaggctcacc ctgagcgagg tggggctaga ggaagcctct     4920

gacacaggaa gtgggcgcat agcacttgct gtggaaatct gtgcctgccc ccctgcctac     4980

gctggtgact cttgtcaggg ttgtagccct ggatactatc gggatcataa aggcttgtat     5040

accggacggt gtgttccctg caattgcaac ggacattcaa atcaatgcca ggatggctca     5100

ggcatatgtg ttaactgtca gcacaacacc gcgggagagc actgtgaacg ctgccaggag     5160

ggctactatg gcaacgccgt ccacggatcc tgcagggcct gcccatgtcc tcacactaac     5220

agctttgcca ctggctgtgt ggtgaatggg ggagacgtgc ggtgctcctg caaagctggg     5280

tacacaggaa cacagtgtga aaggtgtgca ccgggatatt tcgggaatcc ccagaaattc     5340

ggaggtagct gccaaccatg cagttgtaac agcaatggcc agctgggcag ctgtcatccc     5400

ctgactggag actgcataaa ccaagaaccc aaagatagca gccctgcaga agaatgtgat     5460

gattgcgaca gctgtgtgat gaccctcctg aacgacctgg ccaccatggg cgagcagctc     5520

cgcctggtca agtctcagct gcagggcctg agtgccagcg cagggcttct ggagcagatg     5580

aggcacatgg agacccaggc caaggacctg aggaatcagt tgctcaacta ccgttctgcc     5640

atttcaaatc atggatcaaa aatagaaggc ctggaaagag aactgactga tttgaatcaa     5700

gaatttgaga ctttgcaaga aaaggctcaa gtaaattcca gaaaagcaca aacattaaac     5760

aacaatgtta atcgggcaac acaaagcgca aaagaactgg atgtgaagat taaaaatgtc     5820

atccggaatg tgcacattct tttaaagcag atctctggga cagatggaga gggaaacaac     5880

gtgccttcag gtgacttttc cagagagtgg gctgaagccc agcgcatgat gagggaactg     5940

cggaacagga actttggaaa gcacctcaga gaagcagaag ctgataaaag ggagtcgcag     6000

ctcttgctga accggataag gacctggcag aaaacccacc agggggagaa caatgggctt     6060

gctaacagta tccgggattc tttaaatgaa tacgaagcca aactcagtga ccttcgtgct     6120

cggctgcagg aggcagctgc ccaagccaag caggcaaatg gcttgaacca agaaaacgag     6180

agagctttgg gagccattca gagacaagtg aaagaaataa attccctgca gagtgatttc     6240

accaagtatc taaccactgc agactcatct ttgttgcaaa ccaacattgc gctgcagctg     6300

atggagaaaa gccagaagga atatgaaaaa ttagctgcca gtttaaatga agcaagacaa     6360

gaactaagtg acaaagtaag agaactttcc agatctgctg gcaaaacatc ccttgtggag     6420

gaggcagaaa agcacgcgcg gtccttacaa gagctggcaa agcagctgga agagatcaag     6480

agaaacgcca gcggggatga gctggtgcgc tgtgctgtgg atgccgccac cgcctacgag     6540

aacatcctca atgccatcaa agcggccgag gacgcagcca acagggctgc cagtgcatct     6600

gaatctgccc tccagacagt gataaaggaa gatctgccaa gaaaagctaa aaccctgagt     6660

tccaacagtg ataaactgtt aaatgaagcc aagatgacac aaaagaagct aaagcaagaa     6720

gtcagtccag ctctcaacaa cctacagcaa accctgaata ttgtgacagt tcagaaagaa     6780

gtgatagaca ccaatctcac aactctccga gatggtcttc atgggataca gagaggtgat     6840

attgatgcta tgatcagtag tgcaaagagc atggtcagaa aggccaacga catcacagat     6900

gaggttctgg atgggctcaa ccccatccag acagatgtgg aaagaattaa ggacacctat     6960

gggaggacac agaacgaaga cttcaaaaag gctctgactg atgcagataa ctcggtgaat     7020

aagttaacca acaaactacc tgatctttgg cgcaagattg aaagtatcaa ccaacagctg     7080

ttgcccttgg gaaacatctc tgacaacatg gacagaatac gagaactaat tcagcaggcc     7140

agagatgctg ccagtaaggt tgctgtcccc atgaggttca atggtaaatc tggagtcgaa     7200

gtccgactgc caaatgacct ggaagatttg aaaggatata catctctgtc cttgtttctc     7260

caaaggccca actcaagaga aaatgggggt actgagaata tgtttgtgat gtaccttgga     7320

aataaagatg cctcccggga ctacatcggc atggcagttg tggatggcca gctcacctgt     7380

gtctacaacc tgggggaccg tgaggctgaa ctccaagtgg accagatctt gaccaagagt     7440

gagactaagg aggcagttat ggatcgggtg aaatttcaga gaatttatca gtttgcaagg     7500

cttaattaca ccaaaggagc cacatccagt aaaccagaaa cacccggagt ctatgacatg     7560

gatggtagaa atagcaatac actccttaat ttggatcctg aaaatgttgt attttatgtt     7620

ggaggttacc cacctgattt taaacttccc agtcgactaa gtttccctcc atacaaaggt     7680

tgtattgaat tagatgacct caatgaaaat gttctgagct tgtacaactt caaaaaaaca     7740

ttcaatctca acacaactga agtggagcct tgtagaagga ggaaggaaga gtcagacaaa     7800

aattattttg aaggtacggg ctatgctcga gttccaactc aaccacatgc tcccatccca     7860

acctttggac agacaattca gaccaccgtg gatagaggct tgctgttctt tgcagaaaac     7920

ggggatcgct tcatatctct aaatatagaa gatggcaagc tcatggtgag atacaaactg     7980

aattcagagc taccaaaaga gagaggagtt ggagacgcca taaacaacgg cagagaccat     8040

tcgattcaga tcaaaattgg aaaactccaa aagcgtatgt ggataaatgt ggacgttcaa     8100

aacactataa ttgatggtga agtatttgat ttcagcacat attatctggg aggaattcca     8160

attgcaatca gggaaagatt taacatttct acgcctgctt tccgaggctg catgaaaaat     8220

ttgaagaaaa ccagtggtgt cgttagattg aatgatactg tgggagtaac caaaaagtgc     8280

tcggaagact ggaagcttgt gcgatctgcc tcattctcca gaggaggaca attgagtttc     8340

actgatttgg gcttaccacc tactgaccac ctccaggcct catttggatt tcagaccttt     8400

caacccagtg gcatattatt agatcatcag acatggacaa ggaacctgca ggtcactctg     8460

gaagatggtt acattgaatt gagcaccagc gatagcggca gcccaatttt taaatctcca     8520

cagacgtata tggatggttt actgcattat gtatctgtaa taagcgacaa ctctggacta     8580

cggcttctca tcgatgacca gcttctgaga aatagcaaaa ggctaaaaca catttcaagt     8640

tcccggcagt ctctgcgtct gggcgggagc aattttgagg gttgtattag caatgttttt     8700

gtccagaggt tatcactgag tcctgaagtc ctagatttga ccagtaactc tctcaagaga     8760

gatgtgtccc tgggaggctg cagtttaaac aaaccacctt ttctaatgtt gcttaaaggt     8820

tctaccaggt ttaacaagac caagactttt cgtatcaacc agctgttgca ggacacacca     8880

gtggcctccc caaggagcgt gaaggtgtgg caagatgctt gctcaccact tcccaagacc     8940

caggccaatc atggagccct ccagtttggg gacattccca ccagccactt gctattcaag     9000

cttcctcagg agctgctgaa acccaggtca cagtttgctg tggacatgca gacaacatcc     9060

tccagaggac tggtgtttca cacgggcact aagaactcct ttatggctct ttatctttca     9120

aaaggacgtc tggtctttgc actggggaca gatgggaaaa aattgaggat caaaagcaag     9180

gagaaatgca atgatgggaa atggcacacg gtggtgtttg gccatgatgg ggaaaagggg     9240

cgcttggttg tggatggact gagggcccgg gagggaagtt tgcctggaaa ctccaccatc     9300

agcatcagag cgccagttta cctgggatca cctccatcag ggaaaccaaa gagcctcccc     9360

acaaacagct ttgtgggatg cctgaagaac tttcagctgg attcaaaacc cttgtatacc     9420

ccttcttcaa gcttcggggt gtcttcctgc ttgggtggtc ctttggagaa aggcatttat     9480

ttctctgaag aaggaggtca tgtcgtcttg gctcactctg tattgttggg gccagaattt     9540

aagcttgttt tcagcatccg cccaagaagt ctcactggga tcctaataca catcggaagt     9600

cagcccggga agcacttatg tgtttacctg gaggcaggaa aggtcacggc ctctatggac     9660

agtggggcag gtgggacctc aacgtcggtc acaccaaagc agtctctgtg tgatggacag     9720

tggcactcgg tggcagtcac cataaaacaa cacatcctgc acctggaact ggacacagac     9780

agtagctaca cagctggaca gatccccttc ccacctgcca gcactcaaga gccactacac     9840

cttggaggtg ctccagccaa tttgacgaca ctgaggatcc ctgtgtggaa atcattcttt     9900

ggctgtctga ggaatattca tgtcaatcac atccctgtcc ctgtcactga agccttggaa     9960

gtccaggggc ctgtcagtct gaatggttgt cctgaccagt aa                       10002


<210>  58
<211>  3333
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Ile Leu Leu Lys Gln  Ile Ser Gly 
    1940                 1945                 1950             


Thr Asp  Gly Glu Gly Asn Asn  Val Pro Ser Gly Asp  Phe Ser Arg 
    1955                 1960                 1965             


Glu Trp  Ala Glu Ala Gln Arg  Met Met Arg Glu Leu  Arg Asn Arg 
    1970                 1975                 1980             


Asn Phe  Gly Lys His Leu Arg  Glu Ala Glu Ala Asp  Lys Arg Glu 
    1985                 1990                 1995             


Ser Gln  Leu Leu Leu Asn Arg  Ile Arg Thr Trp Gln  Lys Thr His 
    2000                 2005                 2010             


Gln Gly  Glu Asn Asn Gly Leu  Ala Asn Ser Ile Arg  Asp Ser Leu 
    2015                 2020                 2025             


Asn Glu  Tyr Glu Ala Lys Leu  Ser Asp Leu Arg Ala  Arg Leu Gln 
    2030                 2035                 2040             


Glu Ala  Ala Ala Gln Ala Lys  Gln Ala Asn Gly Leu  Asn Gln Glu 
    2045                 2050                 2055             


Asn Glu  Arg Ala Leu Gly Ala  Ile Gln Arg Gln Val  Lys Glu Ile 
    2060                 2065                 2070             


Asn Ser  Leu Gln Ser Asp Phe  Thr Lys Tyr Leu Thr  Thr Ala Asp 
    2075                 2080                 2085             


Ser Ser  Leu Leu Gln Thr Asn  Ile Ala Leu Gln Leu  Met Glu Lys 
    2090                 2095                 2100             


Ser Gln  Lys Glu Tyr Glu Lys  Leu Ala Ala Ser Leu  Asn Glu Ala 
    2105                 2110                 2115             


Arg Gln  Glu Leu Ser Asp Lys  Val Arg Glu Leu Ser  Arg Ser Ala 
    2120                 2125                 2130             


Gly Lys  Thr Ser Leu Val Glu  Glu Ala Glu Lys His  Ala Arg Ser 
    2135                 2140                 2145             


Leu Gln  Glu Leu Ala Lys Gln  Leu Glu Glu Ile Lys  Arg Asn Ala 
    2150                 2155                 2160             


Ser Gly  Asp Glu Leu Val Arg  Cys Ala Val Asp Ala  Ala Thr Ala 
    2165                 2170                 2175             


Tyr Glu  Asn Ile Leu Asn Ala  Ile Lys Ala Ala Glu  Asp Ala Ala 
    2180                 2185                 2190             


Asn Arg  Ala Ala Ser Ala Ser  Glu Ser Ala Leu Gln  Thr Val Ile 
    2195                 2200                 2205             


Lys Glu  Asp Leu Pro Arg Lys  Ala Lys Thr Leu Ser  Ser Asn Ser 
    2210                 2215                 2220             


Asp Lys  Leu Leu Asn Glu Ala  Lys Met Thr Gln Lys  Lys Leu Lys 
    2225                 2230                 2235             


Gln Glu  Val Ser Pro Ala Leu  Asn Asn Leu Gln Gln  Thr Leu Asn 
    2240                 2245                 2250             


Ile Val  Thr Val Gln Lys Glu  Val Ile Asp Thr Asn  Leu Thr Thr 
    2255                 2260                 2265             


Leu Arg  Asp Gly Leu His Gly  Ile Gln Arg Gly Asp  Ile Asp Ala 
    2270                 2275                 2280             


Met Ile  Ser Ser Ala Lys Ser  Met Val Arg Lys Ala  Asn Asp Ile 
    2285                 2290                 2295             


Thr Asp  Glu Val Leu Asp Gly  Leu Asn Pro Ile Gln  Thr Asp Val 
    2300                 2305                 2310             


Glu Arg  Ile Lys Asp Thr Tyr  Gly Arg Thr Gln Asn  Glu Asp Phe 
    2315                 2320                 2325             


Lys Lys  Ala Leu Thr Asp Ala  Asp Asn Ser Val Asn  Lys Leu Thr 
    2330                 2335                 2340             


Asn Lys  Leu Pro Asp Leu Trp  Arg Lys Ile Glu Ser  Ile Asn Gln 
    2345                 2350                 2355             


Gln Leu  Leu Pro Leu Gly Asn  Ile Ser Asp Asn Met  Asp Arg Ile 
    2360                 2365                 2370             


Arg Glu  Leu Ile Gln Gln Ala  Arg Asp Ala Ala Ser  Lys Val Ala 
    2375                 2380                 2385             


Val Pro  Met Arg Phe Asn Gly  Lys Ser Gly Val Glu  Val Arg Leu 
    2390                 2395                 2400             


Pro Asn  Asp Leu Glu Asp Leu  Lys Gly Tyr Thr Ser  Leu Ser Leu 
    2405                 2410                 2415             


Phe Leu  Gln Arg Pro Asn Ser  Arg Glu Asn Gly Gly  Thr Glu Asn 
    2420                 2425                 2430             


Met Phe  Val Met Tyr Leu Gly  Asn Lys Asp Ala Ser  Arg Asp Tyr 
    2435                 2440                 2445             


Ile Gly  Met Ala Val Val Asp  Gly Gln Leu Thr Cys  Val Tyr Asn 
    2450                 2455                 2460             


Leu Gly  Asp Arg Glu Ala Glu  Leu Gln Val Asp Gln  Ile Leu Thr 
    2465                 2470                 2475             


Lys Ser  Glu Thr Lys Glu Ala  Val Met Asp Arg Val  Lys Phe Gln 
    2480                 2485                 2490             


Arg Ile  Tyr Gln Phe Ala Arg  Leu Asn Tyr Thr Lys  Gly Ala Thr 
    2495                 2500                 2505             


Ser Ser  Lys Pro Glu Thr Pro  Gly Val Tyr Asp Met  Asp Gly Arg 
    2510                 2515                 2520             


Asn Ser  Asn Thr Leu Leu Asn  Leu Asp Pro Glu Asn  Val Val Phe 
    2525                 2530                 2535             


Tyr Val  Gly Gly Tyr Pro Pro  Asp Phe Lys Leu Pro  Ser Arg Leu 
    2540                 2545                 2550             


Ser Phe  Pro Pro Tyr Lys Gly  Cys Ile Glu Leu Asp  Asp Leu Asn 
    2555                 2560                 2565             


Glu Asn  Val Leu Ser Leu Tyr  Asn Phe Lys Lys Thr  Phe Asn Leu 
    2570                 2575                 2580             


Asn Thr  Thr Glu Val Glu Pro  Cys Arg Arg Arg Lys  Glu Glu Ser 
    2585                 2590                 2595             


Asp Lys  Asn Tyr Phe Glu Gly  Thr Gly Tyr Ala Arg  Val Pro Thr 
    2600                 2605                 2610             


Gln Pro  His Ala Pro Ile Pro  Thr Phe Gly Gln Thr  Ile Gln Thr 
    2615                 2620                 2625             


Thr Val  Asp Arg Gly Leu Leu  Phe Phe Ala Glu Asn  Gly Asp Arg 
    2630                 2635                 2640             


Phe Ile  Ser Leu Asn Ile Glu  Asp Gly Lys Leu Met  Val Arg Tyr 
    2645                 2650                 2655             


Lys Leu  Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
    2660                 2665                 2670             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    2675                 2680                 2685             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    2690                 2695                 2700             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    2705                 2710                 2715             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    2720                 2725                 2730             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    2735                 2740                 2745             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    2750                 2755                 2760             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    2765                 2770                 2775             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    2780                 2785                 2790             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    2795                 2800                 2805             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    2810                 2815                 2820             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Ser Pro  Ile Phe Lys 
    2825                 2830                 2835             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    2840                 2845                 2850             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    2855                 2860                 2865             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    2870                 2875                 2880             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    2885                 2890                 2895             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    2900                 2905                 2910             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    2915                 2920                 2925             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    2930                 2935                 2940             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    2945                 2950                 2955             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    2960                 2965                 2970             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    2975                 2980                 2985             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    2990                 2995                 3000             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    3005                 3010                 3015             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    3020                 3025                 3030             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    3035                 3040                 3045             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    3050                 3055                 3060             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    3065                 3070                 3075             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    3080                 3085                 3090             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    3095                 3100                 3105             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    3110                 3115                 3120             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    3125                 3130                 3135             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    3140                 3145                 3150             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    3155                 3160                 3165             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    3170                 3175                 3180             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    3185                 3190                 3195             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    3200                 3205                 3210             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    3215                 3220                 3225             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    3230                 3235                 3240             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    3245                 3250                 3255             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    3260                 3265                 3270             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    3275                 3280                 3285             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    3290                 3295                 3300             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    3305                 3310                 3315             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    3320                 3325                 3330             


<210>  59
<211>  1851
<212>  DNA
<213>  Homo sapiens

<400>  59
atggcagaag atgagcctga tgctaagagc cccaagactg ggggaagggc ccccccaggt       60

ggtgctgagg ctggggaacc taccaccctt cttcagaggc tccgaggtac catttccaag      120

gccgtgcaga acaaagtaga ggggatcctg caagatgtac agaaattttc tgacaatgac      180

aagctgtatc tctaccttca gctcccctca ggacccacca ctggagacaa aagctcagag      240

ccaagtacac tgagcaatga ggagtacatg tatgcctata ggtggatccg caaccacctg      300

gaagagcaca ctgacacctg tctgccaaag caaagtgttt atgatgccta tcggaagtac      360

tgtgagagtc ttgcctgttg ccgcccactc agcacagcca actttggcaa gatcatcaga      420

gagatcttcc ctgacatcaa agctcgaagg cttggtggcc ggggccagtc caaatattgc      480

tacagtggca taaggaggaa gaccttggtg tctatgccac ccctgcctgg acttgaccta      540

aagggttctg agagtccaga aatgggccca gaagtaaccc cagcacctcg agatgaactg      600

gtggaggcag cgtgtgccct gacctgtgac tgggcagagc ggatcctgaa acggtccttc      660

agttccatcg ttgaggtcgc ccgcttcctg ctacagcagc atctcatctc tgcccgatct      720

gcacatgccc atgtgcttaa ggccatgggg ctcgctgaag aggacgaaca tgcacctcgg      780

gaacggtcat ctaaaccaaa gaatggttta gagaacccag agggtggagc ccacaagaag      840

ccagagagac tggcccagcc tcctaaggat ctggaagccc gaactggggc cggtcctctc      900

gcacgtggag agcggaagaa gagtgtagtt gagagctcgg ccccaggagc caataacctg      960

caggttaatg ccctagtggc tcggctgcct ctgctccttc cccgggcccc tcgctcacta     1020

attccgccaa tcccagtctc tccacctatt ctggccccca ggctttcttc aggtgccctg     1080

aaagtggcta cactgcctct gtctagtagg gccggggcac ccccagcagc tgtgcccatc     1140

attaacatga tcttaccaac tgttcctgct ttgcctggac ctggacctgg gcctgggcga     1200

gctccacctg ggggactcac tcagccccgg ggcacagaga acagagaggt aggcataggt     1260

ggtgaccaag gaccacatga caagggtgtc aagaggacag ctgaagtacc tgtgagtgag     1320

gccagtgggc aggctccacc agctaaagca gcaaagcagg atatagagga tacagcaagt     1380

gatgccaaaa ggaaacgggg gcgccctcga aaaaagtcag gtggaagtgg ggaaaggaat     1440

tctacccctc tcaagtcagc agctgccatg gaatctgccc agtcctcaag gttaccatgg     1500

gagacatggg gctcaggagg ggaaggcaac tcagctggag gggcagagag gccagggcca     1560

atgggagagg ctgaaaaggg ggcagtactt gcccagggtc agggagatgg tactgtttcc     1620

aaaggaggaa ggggccccgg ttcccagcat accaaagaag cagaagataa aattcccttg     1680

gtcccctcaa aagtgagtgt catcaagggc agcagaagcc aaaaggaggc ttttcctttg     1740

gcaaagggag aggtagacac tgcaccacag ggtaataaag acttaaagga gcatgtgctt     1800

caaagttcct tatcccagga gcataaagac ccaaaagcaa cacccccatg a              1851


<210>  60
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Glu Asp Glu Pro Asp Ala Lys Ser Pro Lys Thr Gly Gly Arg 
1               5                   10                  15      


Ala Pro Pro Gly Gly Ala Glu Ala Gly Glu Pro Thr Thr Leu Leu Gln 
            20                  25                  30          


Arg Leu Arg Gly Thr Ile Ser Lys Ala Val Gln Asn Lys Val Glu Gly 
        35                  40                  45              


Ile Leu Gln Asp Val Gln Lys Phe Ser Asp Asn Asp Lys Leu Tyr Leu 
    50                  55                  60                  


Tyr Leu Gln Leu Pro Ser Gly Pro Thr Thr Gly Asp Lys Ser Ser Glu 
65                  70                  75                  80  


Pro Ser Thr Leu Ser Asn Glu Glu Tyr Met Tyr Ala Tyr Arg Trp Ile 
                85                  90                  95      


Arg Asn His Leu Glu Glu His Thr Asp Thr Cys Leu Pro Lys Gln Ser 
            100                 105                 110         


Val Tyr Asp Ala Tyr Arg Lys Tyr Cys Glu Ser Leu Ala Cys Cys Arg 
        115                 120                 125             


Pro Leu Ser Thr Ala Asn Phe Gly Lys Ile Ile Arg Glu Ile Phe Pro 
    130                 135                 140                 


Asp Ile Lys Ala Arg Arg Leu Gly Gly Arg Gly Gln Ser Lys Tyr Cys 
145                 150                 155                 160 


Tyr Ser Gly Ile Arg Arg Lys Thr Leu Val Ser Met Pro Pro Leu Pro 
                165                 170                 175     


Gly Leu Asp Leu Lys Gly Ser Glu Ser Pro Glu Met Gly Pro Glu Val 
            180                 185                 190         


Thr Pro Ala Pro Arg Asp Glu Leu Val Glu Ala Ala Cys Ala Leu Thr 
        195                 200                 205             


Cys Asp Trp Ala Glu Arg Ile Leu Lys Arg Ser Phe Ser Ser Ile Val 
    210                 215                 220                 


Glu Val Ala Arg Phe Leu Leu Gln Gln His Leu Ile Ser Ala Arg Ser 
225                 230                 235                 240 


Ala His Ala His Val Leu Lys Ala Met Gly Leu Ala Glu Glu Asp Glu 
                245                 250                 255     


His Ala Pro Arg Glu Arg Ser Ser Lys Pro Lys Asn Gly Leu Glu Asn 
            260                 265                 270         


Pro Glu Gly Gly Ala His Lys Lys Pro Glu Arg Leu Ala Gln Pro Pro 
        275                 280                 285             


Lys Asp Leu Glu Ala Arg Thr Gly Ala Gly Pro Leu Ala Arg Gly Glu 
    290                 295                 300                 


Arg Lys Lys Ser Val Val Glu Ser Ser Ala Pro Gly Ala Asn Asn Leu 
305                 310                 315                 320 


Gln Val Asn Ala Leu Val Ala Arg Leu Pro Leu Leu Leu Pro Arg Ala 
                325                 330                 335     


Pro Arg Ser Leu Ile Pro Pro Ile Pro Val Ser Pro Pro Ile Leu Ala 
            340                 345                 350         


Pro Arg Leu Ser Ser Gly Ala Leu Lys Val Ala Thr Leu Pro Leu Ser 
        355                 360                 365             


Ser Arg Ala Gly Ala Pro Pro Ala Ala Val Pro Ile Ile Asn Met Ile 
    370                 375                 380                 


Leu Pro Thr Val Pro Ala Leu Pro Gly Pro Gly Pro Gly Pro Gly Arg 
385                 390                 395                 400 


Ala Pro Pro Gly Gly Leu Thr Gln Pro Arg Gly Thr Glu Asn Arg Glu 
                405                 410                 415     


Val Gly Ile Gly Gly Asp Gln Gly Pro His Asp Lys Gly Val Lys Arg 
            420                 425                 430         


Thr Ala Glu Val Pro Val Ser Glu Ala Ser Gly Gln Ala Pro Pro Ala 
        435                 440                 445             


Lys Ala Ala Lys Gln Asp Ile Glu Asp Thr Ala Ser Asp Ala Lys Arg 
    450                 455                 460                 


Lys Arg Gly Arg Pro Arg Lys Lys Ser Gly Gly Ser Gly Glu Arg Asn 
465                 470                 475                 480 


Ser Thr Pro Leu Lys Ser Ala Ala Ala Met Glu Ser Ala Gln Ser Ser 
                485                 490                 495     


Arg Leu Pro Trp Glu Thr Trp Gly Ser Gly Gly Glu Gly Asn Ser Ala 
            500                 505                 510         


Gly Gly Ala Glu Arg Pro Gly Pro Met Gly Glu Ala Glu Lys Gly Ala 
        515                 520                 525             


Val Leu Ala Gln Gly Gln Gly Asp Gly Thr Val Ser Lys Gly Gly Arg 
    530                 535                 540                 


Gly Pro Gly Ser Gln His Thr Lys Glu Ala Glu Asp Lys Ile Pro Leu 
545                 550                 555                 560 


Val Pro Ser Lys Val Ser Val Ile Lys Gly Ser Arg Ser Gln Lys Glu 
                565                 570                 575     


Ala Phe Pro Leu Ala Lys Gly Glu Val Asp Thr Ala Pro Gln Gly Asn 
            580                 585                 590         


Lys Asp Leu Lys Glu His Val Leu Gln Ser Ser Leu Ser Gln Glu His 
        595                 600                 605             


Lys Asp Pro Lys Ala Thr Pro Pro 
    610                 615     


<210>  61
<211>  3795
<212>  DNA
<213>  Homo sapiens

<400>  61
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata       60

gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc      120

tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg      180

gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg      240

ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc      300

agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga      360

ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc      420

cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct      480

gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc      540

cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc      600

cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca      660

ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa      720

cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca      780

ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat      840

gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac      900

agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag      960

ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc     1020

atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc     1080

caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc     1140

tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag     1200

ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag     1260

gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg     1320

gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc     1380

cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc     1440

ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg     1500

ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat     1560

aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca     1620

atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag     1680

gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt     1740

gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac     1800

tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc     1860

ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg     1920

ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg     1980

ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt     2040

cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc     2100

ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc     2160

atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac     2220

ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag     2280

gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc     2340

cagcaagatg aggatgtatt ggatacctgg ttctcctctg gcctcttccc cttatccatt     2400

ttgggctggc ccaaccagtc agaagacctg agtgtgttct accccgggac actgctggag     2460

accggtcatg acatcctctt cttctgggtg gcccggatgg tcatgctggg cctgaagctc     2520

acgggcaggc tgccctttag agaggtctac ctccatgcca tcgtgcgaga tgctcacggc     2580

cggaagatga gcaagtctct aggcaatgtc atcgatcccc tggacgtcat ctatggaatc     2640

tccctgcagg gcctccacaa ccagctgctg aacagcaacc tggatcccag cgaggtggag     2700

aaggccaaag aagggcagaa agctgacttc ccagcgggga ttcctgaatg tggcaccgat     2760

gctctccggt ttggattatg tgcctacatg tcccagggtc gtgacatcaa cctggatgtg     2820

aaccggatac tgggttaccg ccacttctgc aacaagctct ggaatgccac caagtttgcc     2880

cttcgtggcc ttgggaaggg ttttgtgccc tcacccacct cccagcccgg aggccatgag     2940

agcctggtgg accgctggat ccgcagccgc ctgacagagg ctgtgaggct cagcaatcaa     3000

ggcttccagg cctacgactt cccggccgtc accactgccc agtacagctt ctggctctat     3060

gagctctgtg atgtctactt ggagtgcctg aaacctgtac tgaatggggt ggaccaggtg     3120

gcagctgagt gtgcccgcca gaccctgtac acttgcctgg acgttggcct gcggctgctc     3180

tcacccttca tgcccttcgt gacggaggag ctgttccaga ggctgccccg gaggatgccg     3240

caagctcccc ctagcctctg tgttaccccc tacccggagc cctcagagtg ctcctggaag     3300

gaccccgagg cagaagccgc ccttgagctg gcgctaagca tcacgcgagc cgtgcgctcc     3360

ctgcgggccg actacaacct cacccggatc cggcctgact gtttcctgga agtggcggat     3420

gaggccacgg gcgccctggc atcggcggtg tcgggctacg tgcaggccct ggccagcgca     3480

ggtgtggtgg ctgttctggc cctgggggct cccgcccccc agggttgcgc tgtggctctg     3540

gcttctgatc gctgctccat ccacctgcag cttcaggggc tggtggaccc tgcacgggag     3600

ctgggcaagc tgcaagccaa gcgagttgag gcccagcggc aggcccagcg tctgcgggaa     3660

cgccgtgctg cctcgggcta tcctgtcaag gtgccgctcg aagtccagga ggcagatgaa     3720

gccaagctcc aacagacaga agcagagctc aggaaggtgg atgaggccat cgccctattc     3780

cagaagatgc tgtga                                                      3795


<210>  62
<211>  1264
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu 
1               5                   10                  15      


Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly 
            20                  25                  30          


Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser 
        35                  40                  45              


Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro 
    50                  55                  60                  


Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp 
65                  70                  75                  80  


Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val 
                85                  90                  95      


Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys 
            100                 105                 110         


Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro 
        115                 120                 125             


Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu 
    130                 135                 140                 


Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala 
145                 150                 155                 160 


Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu 
                165                 170                 175     


Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val 
            180                 185                 190         


Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val 
        195                 200                 205             


Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala 
    210                 215                 220                 


Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys 
225                 230                 235                 240 


Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln 
                245                 250                 255     


Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys 
            260                 265                 270         


Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu 
        275                 280                 285             


Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr 
    290                 295                 300                 


Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys 
305                 310                 315                 320 


Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val 
                325                 330                 335     


Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu 
            340                 345                 350         


Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His 
        355                 360                 365             


Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala 
    370                 375                 380                 


Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln 
385                 390                 395                 400 


Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val 
                405                 410                 415     


Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys 
            420                 425                 430         


Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp 
        435                 440                 445             


Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu 
    450                 455                 460                 


Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr 
465                 470                 475                 480 


Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr 
                485                 490                 495     


Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe 
            500                 505                 510         


Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp 
        515                 520                 525             


Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp 
    530                 535                 540                 


Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys 
545                 550                 555                 560 


Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val 
                565                 570                 575     


Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile 
            580                 585                 590         


Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly 
        595                 600                 605             


Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val 
    610                 615                 620                 


Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val 
625                 630                 635                 640 


Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn 
                645                 650                 655     


Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro 
            660                 665                 670         


Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala 
        675                 680                 685             


Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala 
    690                 695                 700                 


His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys 
705                 710                 715                 720 


Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val 
                725                 730                 735     


Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg 
            740                 745                 750         


Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala 
        755                 760                 765             


Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu 
    770                 775                 780                 


Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile 
785                 790                 795                 800 


Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly 
                805                 810                 815     


Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val Ala Arg 
            820                 825                 830         


Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu 
        835                 840                 845             


Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser 
    850                 855                 860                 


Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile 
865                 870                 875                 880 


Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro 
                885                 890                 895     


Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala 
            900                 905                 910         


Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala 
        915                 920                 925             


Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu 
    930                 935                 940                 


Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala 
945                 950                 955                 960 


Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro 
                965                 970                 975     


Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr 
            980                 985                 990         


Glu Ala Val Arg Leu Ser Asn Gln  Gly Phe Gln Ala Tyr  Asp Phe Pro 
        995                 1000                 1005             


Ala Val  Thr Thr Ala Gln Tyr  Ser Phe Trp Leu Tyr  Glu Leu Cys 
    1010                 1015                 1020             


Asp Val  Tyr Leu Glu Cys Leu  Lys Pro Val Leu Asn  Gly Val Asp 
    1025                 1030                 1035             


Gln Val  Ala Ala Glu Cys Ala  Arg Gln Thr Leu Tyr  Thr Cys Leu 
    1040                 1045                 1050             


Asp Val  Gly Leu Arg Leu Leu  Ser Pro Phe Met Pro  Phe Val Thr 
    1055                 1060                 1065             


Glu Glu  Leu Phe Gln Arg Leu  Pro Arg Arg Met Pro  Gln Ala Pro 
    1070                 1075                 1080             


Pro Ser  Leu Cys Val Thr Pro  Tyr Pro Glu Pro Ser  Glu Cys Ser 
    1085                 1090                 1095             


Trp Lys  Asp Pro Glu Ala Glu  Ala Ala Leu Glu Leu  Ala Leu Ser 
    1100                 1105                 1110             


Ile Thr  Arg Ala Val Arg Ser  Leu Arg Ala Asp Tyr  Asn Leu Thr 
    1115                 1120                 1125             


Arg Ile  Arg Pro Asp Cys Phe  Leu Glu Val Ala Asp  Glu Ala Thr 
    1130                 1135                 1140             


Gly Ala  Leu Ala Ser Ala Val  Ser Gly Tyr Val Gln  Ala Leu Ala 
    1145                 1150                 1155             


Ser Ala  Gly Val Val Ala Val  Leu Ala Leu Gly Ala  Pro Ala Pro 
    1160                 1165                 1170             


Gln Gly  Cys Ala Val Ala Leu  Ala Ser Asp Arg Cys  Ser Ile His 
    1175                 1180                 1185             


Leu Gln  Leu Gln Gly Leu Val  Asp Pro Ala Arg Glu  Leu Gly Lys 
    1190                 1195                 1200             


Leu Gln  Ala Lys Arg Val Glu  Ala Gln Arg Gln Ala  Gln Arg Leu 
    1205                 1210                 1215             


Arg Glu  Arg Arg Ala Ala Ser  Gly Tyr Pro Val Lys  Val Pro Leu 
    1220                 1225                 1230             


Glu Val  Gln Glu Ala Asp Glu  Ala Lys Leu Gln Gln  Thr Glu Ala 
    1235                 1240                 1245             


Glu Leu  Arg Lys Val Asp Glu  Ala Ile Ala Leu Phe  Gln Lys Met 
    1250                 1255                 1260             


Leu 
    


<210>  63
<211>  2524
<212>  DNA
<213>  Homo sapiens

<400>  63
aacggcctcc cgctggcagc cccgaagccg caccatgttc cgcctctggt tgctgctggc       60

cgggctctgc ggcctcctgg cgtcaagacc cggttttcaa aattcacttc tacagatcgt      120

aattccagag aaaatccaaa caaatacaaa tgacagttca gaaatagaat atgaacaaat      180

atcctatatt attccaatag atgagaaact gtacactgtg caccttaaac aaagatattt      240

tttagcagat aattttatga tctatttgta caatcaagga tctatgaata cttattcttc      300

agatattcag actcaatgct actatcaagg aaatattgaa ggatatccag attccatggt      360

cacactcagc acgtgctctg gactaagagg aatactgcaa tttgaaaatg tttcttatgg      420

aattgagcct ctggaatctg cagttgaatt tcagcatgtt ctttacaaat taaagaatga      480

agacaatgat attgcaattt ttattgacag aagcctgaaa gaacaaccaa tggatgacaa      540

catttttata agtgaaaaat cagaaccagc tgttccagat ttatttcctc tttatctaga      600

aatgcatatt gtggtggaca aaactttgta tgattactgg ggctctgata gcatgatagt      660

aacaaataaa gtcatcgaaa ttgttggcct tgcaaattca atgttcaccc aatttaaagt      720

tactattgtg ctgtcatcat tggagttatg gtcagatgaa aataagattt ctacagttgg      780

tgaggcagat gaattattgc aaaaattttt agaatggaaa caatcttatc ttaacctaag      840

gcctcatgat attgcatatc tactaattta tatggattat cctcgttatt tgggagcagt      900

gtttcctgga acaatgtgta ttactcgtta ttctgcagga gttgcattgt accccaagga      960

gataactctg gaggcatttg cagttattgt cacccagatg ctggcactca gtctgggaat     1020

atcatatgac gacccaaaga aatgtcaatg ttcagaatcc acctgtataa tgaatccaga     1080

agttgtgcaa tccaatggtg tgaagacttt tagcagttgc agtttgagga gctttcaaaa     1140

tttcatttca aatgtgggtg tcaaatgtct tcagaataag ccacaaatgc aaaaaaaatc     1200

tccgaaacca gtctgtggca atggcagatt ggagggaaat gaaatctgtg attgtggtac     1260

tgaggctcaa tgtggacctg caagctgttg tgattttcga acttgtgtac tgaaagacgg     1320

agcaaaatgt tataaaggac tgtgctgcaa agactgtcaa attttacaat caggcgttga     1380

atgtaggccg aaagcacatc ctgaatgtga catcgctgaa aattgtaatg gaagctcacc     1440

agaatgtggt cctgacataa ctttaatcaa tggactttca tgcaaaaata ataagtttat     1500

ttgttatgac ggagactgcc atgatctcga tgcacgttgt gagagtgtat ttggaaaagg     1560

ttcaagaaat gctccatttg cctgctatga agaaatacaa tctcaatcag acagatttgg     1620

gaactgtggt agggatagaa ataacaaata tgtgttctgt ggatggagga atcttatatg     1680

tggaagatta gtttgtacct accctactcg aaagcctttc catcaagaaa atggtgatgt     1740

gatttatgct ttcgtacgag attctgtatg cataactgta gactacaaat tgcctcgaac     1800

agttccagat ccactggctg tcaaaaatgg ctctcagtgt gatattggga gggtttgtgt     1860

aaatcgtgaa tgtgtagaat caaggataat taaggcttca gcacatgttt gttcacaaca     1920

gtgttctgga catggagtgt gtgattccag aaacaagtgc cattgttcgc caggctataa     1980

gcctccaaac tgccaaatac gttccaaagg attttccata tttcctgagg aagatatggg     2040

ttcaatcatg gaaagagcat ctgggaagac tgaaaacacc tggcttctag gtttcctcat     2100

tgctcttcct attctcattg taacaaccgc aatagttttg gcaaggaaac agttgaaaaa     2160

gtggttcgcc aaggaagagg aattcccaag tagcgaatct aaatcggaag gtagcacaca     2220

gacatatgcc agccaatcca gctcagaagg cagcactcag acatatgcca gccaaaccag     2280

atcagaaagc agcagtcaag ctgatactag caaatccaaa tcagaagata gtgctgaagc     2340

atatactagc agatccaaat cacaggacag tacccaaaca caaagcagta gtaactagtg     2400

attccttcag aaggcaacgg ataacatcga gagtctcgct aagaaatgaa aattctgtct     2460

ttccttccgt ggtcacagct gaaagaaaca ataaattgag tgtggaccaa aaaaaaaaaa     2520

aaaa                                                                  2524


<210>  64
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Thr Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Thr Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Thr Gln Phe Lys Val Thr Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Thr Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Thr Met Cys Ile Thr Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Tyr Pro Lys Glu Ile Thr Leu Glu Ala Phe Ala Val Ile Val Thr 
305                 310                 315                 320 


Gln Met Leu Ala Leu Ser Leu Gly Ile Ser Tyr Asp Asp Pro Lys Lys 
                325                 330                 335     


Cys Gln Cys Ser Glu Ser Thr Cys Ile Met Asn Pro Glu Val Val Gln 
            340                 345                 350         


Ser Asn Gly Val Lys Thr Phe Ser Ser Cys Ser Leu Arg Ser Phe Gln 
        355                 360                 365             


Asn Phe Ile Ser Asn Val Gly Val Lys Cys Leu Gln Asn Lys Pro Gln 
    370                 375                 380                 


Met Gln Lys Lys Ser Pro Lys Pro Val Cys Gly Asn Gly Arg Leu Glu 
385                 390                 395                 400 


Gly Asn Glu Ile Cys Asp Cys Gly Thr Glu Ala Gln Cys Gly Pro Ala 
                405                 410                 415     


Ser Cys Cys Asp Phe Arg Thr Cys Val Leu Lys Asp Gly Ala Lys Cys 
            420                 425                 430         


Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val 
        435                 440                 445             


Glu Cys Arg Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys 
    450                 455                 460                 


Asn Gly Ser Ser Pro Glu Cys Gly Pro Asp Ile Thr Leu Ile Asn Gly 
465                 470                 475                 480 


Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His 
                485                 490                 495     


Asp Leu Asp Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn 
            500                 505                 510         


Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe 
        515                 520                 525             


Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp 
    530                 535                 540                 


Arg Asn Leu Ile Cys Gly Arg Leu Val Cys Thr Tyr Pro Thr Arg Lys 
545                 550                 555                 560 


Pro Phe His Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp 
                565                 570                 575     


Ser Val Cys Ile Thr Val Asp Tyr Lys Leu Pro Arg Thr Val Pro Asp 
            580                 585                 590         


Pro Leu Ala Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys 
        595                 600                 605             


Val Asn Arg Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His 
    610                 615                 620                 


Val Cys Ser Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn 
625                 630                 635                 640 


Lys Cys His Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg 
                645                 650                 655     


Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met 
            660                 665                 670         


Glu Arg Ala Ser Gly Lys Thr Glu Asn Thr Trp Leu Leu Gly Phe Leu 
        675                 680                 685             


Ile Ala Leu Pro Ile Leu Ile Val Thr Thr Ala Ile Val Leu Ala Arg 
    690                 695                 700                 


Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser 
705                 710                 715                 720 


Glu Ser Lys Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Ser Ser 
                725                 730                 735     


Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Thr Arg Ser Glu Ser 
            740                 745                 750         


Ser Ser Gln Ala Asp Thr Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu 
        755                 760                 765             


Ala Tyr Thr Ser Arg Ser Lys Ser Gln Asp Ser Thr Gln Thr Gln Ser 
    770                 775                 780                 


Ser Ser Asn 
785         


<210>  65
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  65
atggccgggc ccctgcgcgc cccgctgctc ctgctggcca tcctggccgt ggccctggcc       60

gtgagccccg cggccggctc cagtcccggc aagccgccgc gcctagtggg aggccccatg      120

gacgccagcg tggaggagga gggtgtgcgg cgtgcactgg actttgccgt cggcgagtac      180

aacaaagcca gcaacgacat gtaccacagc cgcgcgctgc aggtggtgcg cgcccgcaag      240

cagatcgtag ctggggtgaa ctacttcttg gacgtggagc tgggccgaac cacgtgtacc      300

aagacccagc ccaacttgga caactgcccc ttccatgacc agccacatct gaaaaggaaa      360

gcattctgct ctttccagat ctacgctgtg ccttggcagg gcacaatgac cttgtcgaaa      420

tccacctgtc aggacgccta g                                                441


<210>  66
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  67
<211>  2253
<212>  DNA
<213>  Homo sapiens

<400>  67
atgctatcca gccggtggtg gccaagttcc tgggggatcc tagggctggg cccccgaagc       60

cctcctcggg gatcccagct ctgtgccctc tatgccttta cttatactgg ggcagatggc      120

cagcaggtgt ctctggctga aggggatagg ttcctactgc ttcgaaagac caactccgac      180

tggtggttgg caagacgcct agaagctccc tccacctctc gacccatctt cgtcccagca      240

gcctatatga tagaggaatc catcccttcc cagagtccaa ctaccgtcat ccccggccaa      300

ttgctctgga ctcctgggcc gaagttgttt catggttccc tggaggagtt gtctcaggcc      360

ctcccaagca gggctcaggc tagctcggag cagcctcctc cacttccccg caaaatgtgt      420

aggagcgtca gcactgacaa tctgagcccc agctttctga agcctttcca ggaaggacca      480

agcggaagat ccctctccca ggaagacttg ccgtcagaag ccagtgccag cacagcaggc      540

ccccagcccc tcatgtcaga gccccctgtg tactgtaacc tggtggacct tcgccgctgt      600

cctcggtccc cacccccagg ccctgcatgc cccctgctgc agaggctgga tgcctgggag      660

cagcacctgg accccaactc tggacgctgc ttctacataa attcactgac tggctgcaag      720

tcctggaagc ccccgcgccg cagtcgcagc gagacgaacc ctggctccat ggaggggaca      780

cagaccctga agaggaacaa tgatgtcctg caacctcagg caaagggctt cagatctgac      840

acagggaccc cagaaccgct tgacccacag ggttcactca gcctcagcca acgcacctcg      900

cagcttgacc ctccagcctt gcaggcccct cgacctctgc cgcagctcct ggacgacccc      960

catgaggtgg aaaagtcggg tctgctcaac atgaccaaga ttgcccaagg ggggcgcaag     1020

ctcaggaaga actggggccc gtcttgggtg gtgttaacgg gtaacagcct ggtgttctac     1080

cgagagccac cgccgacagc gccctcctca ggctggggac cagcgggtag ccggcccgaa     1140

agtagcgtgg acctgcgcgg ggcggccctg gcgcacggcc gccacctgtc cagccgccgc     1200

aacgtcctgc acatccgcac gatccctggc cacgagttcc tgctgcagtc ggaccacgag     1260

acagagctgc gagcctggca ccgcgcgctg cggactgtca tcgagcggct ggttagatgg     1320

gtggaggccc ggagggaggc tccgaccggc cgggaccaag ggagtgggga tcgggagaac     1380

cccctggagc tgcgtctgtc gggctctgga cccgcggagc tgagcgccgg ggaggacgaa     1440

gaagaggagt cggagctggt gtccaagccg ctgctgcgcc tcagcagccg ccggagctcc     1500

attcgggggc ccgaaggcac cgagcagaac cgcgtgcgca acaaactaaa gcggctcatc     1560

gcgaagagac cgcccttaca aagcctgcag gagcggggtc tgctccgaga ccaggtgttc     1620

ggctgccagt tggaatcact ctgccagcgg gaaggagaca cggtgcccag ctttttgcgg     1680

ctctgcattg ctgctgtgga taaaagaggt ctagatgtgg atggcattta tcgggtgagc     1740

gggaacttgg cagtggtcca gaagcttcgc tttctggtgg acagagagcg tgcggtcacc     1800

tccgatggga ggtatgtgtt cccagaacag ccaggacaag aaggtcggtt agatttggac     1860

agtactgagt gggatgacat tcatgtggtc accggagccc tgaagctttt tctccgggag     1920

ctgccccagc ctctggtgcc accactgctg ctgccccatt tccgtgctgc ccttgcactc     1980

tccgaatcag agcagtgcct ctctcagata caagaattaa taggctcaat gccaaagccc     2040

aaccatgaca ctctacggta cctcctggag catttatgca gggtgatagc acactcagat     2100

aagaatcgca tgacacccca caacctggga attgtgtttg gaccaaccct gtttcggcca     2160

gagcaggaga catctgaccc agcagcccat gctctctacc cagggcagct ggtccagctg     2220

atgctcacca acttcaccag cctcttcccc tga                                  2253


<210>  68
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Ser Ser Arg Trp Trp Pro Ser Ser Trp Gly Ile Leu Gly Leu 
1               5                   10                  15      


Gly Pro Arg Ser Pro Pro Arg Gly Ser Gln Leu Cys Ala Leu Tyr Ala 
            20                  25                  30          


Phe Thr Tyr Thr Gly Ala Asp Gly Gln Gln Val Ser Leu Ala Glu Gly 
        35                  40                  45              


Asp Arg Phe Leu Leu Leu Arg Lys Thr Asn Ser Asp Trp Trp Leu Ala 
    50                  55                  60                  


Arg Arg Leu Glu Ala Pro Ser Thr Ser Arg Pro Ile Phe Val Pro Ala 
65                  70                  75                  80  


Ala Tyr Met Ile Glu Glu Ser Ile Pro Ser Gln Ser Pro Thr Thr Val 
                85                  90                  95      


Ile Pro Gly Gln Leu Leu Trp Thr Pro Gly Pro Lys Leu Phe His Gly 
            100                 105                 110         


Ser Leu Glu Glu Leu Ser Gln Ala Leu Pro Ser Arg Ala Gln Ala Ser 
        115                 120                 125             


Ser Glu Gln Pro Pro Pro Leu Pro Arg Lys Met Cys Arg Ser Val Ser 
    130                 135                 140                 


Thr Asp Asn Leu Ser Pro Ser Phe Leu Lys Pro Phe Gln Glu Gly Pro 
145                 150                 155                 160 


Ser Gly Arg Ser Leu Ser Gln Glu Asp Leu Pro Ser Glu Ala Ser Ala 
                165                 170                 175     


Ser Thr Ala Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys 
            180                 185                 190         


Asn Leu Val Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro 
        195                 200                 205             


Ala Cys Pro Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp 
    210                 215                 220                 


Pro Asn Ser Gly Arg Cys Phe Tyr Ile Asn Ser Leu Thr Gly Cys Lys 
225                 230                 235                 240 


Ser Trp Lys Pro Pro Arg Arg Ser Arg Ser Glu Thr Asn Pro Gly Ser 
                245                 250                 255     


Met Glu Gly Thr Gln Thr Leu Lys Arg Asn Asn Asp Val Leu Gln Pro 
            260                 265                 270         


Gln Ala Lys Gly Phe Arg Ser Asp Thr Gly Thr Pro Glu Pro Leu Asp 
        275                 280                 285             


Pro Gln Gly Ser Leu Ser Leu Ser Gln Arg Thr Ser Gln Leu Asp Pro 
    290                 295                 300                 


Pro Ala Leu Gln Ala Pro Arg Pro Leu Pro Gln Leu Leu Asp Asp Pro 
305                 310                 315                 320 


His Glu Val Glu Lys Ser Gly Leu Leu Asn Met Thr Lys Ile Ala Gln 
                325                 330                 335     


Gly Gly Arg Lys Leu Arg Lys Asn Trp Gly Pro Ser Trp Val Val Leu 
            340                 345                 350         


Thr Gly Asn Ser Leu Val Phe Tyr Arg Glu Pro Pro Pro Thr Ala Pro 
        355                 360                 365             


Ser Ser Gly Trp Gly Pro Ala Gly Ser Arg Pro Glu Ser Ser Val Asp 
    370                 375                 380                 


Leu Arg Gly Ala Ala Leu Ala His Gly Arg His Leu Ser Ser Arg Arg 
385                 390                 395                 400 


Asn Val Leu His Ile Arg Thr Ile Pro Gly His Glu Phe Leu Leu Gln 
                405                 410                 415     


Ser Asp His Glu Thr Glu Leu Arg Ala Trp His Arg Ala Leu Arg Thr 
            420                 425                 430         


Val Ile Glu Arg Leu Val Arg Trp Val Glu Ala Arg Arg Glu Ala Pro 
        435                 440                 445             


Thr Gly Arg Asp Gln Gly Ser Gly Asp Arg Glu Asn Pro Leu Glu Leu 
    450                 455                 460                 


Arg Leu Ser Gly Ser Gly Pro Ala Glu Leu Ser Ala Gly Glu Asp Glu 
465                 470                 475                 480 


Glu Glu Glu Ser Glu Leu Val Ser Lys Pro Leu Leu Arg Leu Ser Ser 
                485                 490                 495     


Arg Arg Ser Ser Ile Arg Gly Pro Glu Gly Thr Glu Gln Asn Arg Val 
            500                 505                 510         


Arg Asn Lys Leu Lys Arg Leu Ile Ala Lys Arg Pro Pro Leu Gln Ser 
        515                 520                 525             


Leu Gln Glu Arg Gly Leu Leu Arg Asp Gln Val Phe Gly Cys Gln Leu 
    530                 535                 540                 


Glu Ser Leu Cys Gln Arg Glu Gly Asp Thr Val Pro Ser Phe Leu Arg 
545                 550                 555                 560 


Leu Cys Ile Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile 
                565                 570                 575     


Tyr Arg Val Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu 
            580                 585                 590         


Val Asp Arg Glu Arg Ala Val Thr Ser Asp Gly Arg Tyr Val Phe Pro 
        595                 600                 605             


Glu Gln Pro Gly Gln Glu Gly Arg Leu Asp Leu Asp Ser Thr Glu Trp 
    610                 615                 620                 


Asp Asp Ile His Val Val Thr Gly Ala Leu Lys Leu Phe Leu Arg Glu 
625                 630                 635                 640 


Leu Pro Gln Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala 
                645                 650                 655     


Ala Leu Ala Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu 
            660                 665                 670         


Leu Ile Gly Ser Met Pro Lys Pro Asn His Asp Thr Leu Arg Tyr Leu 
        675                 680                 685             


Leu Glu His Leu Cys Arg Val Ile Ala His Ser Asp Lys Asn Arg Met 
    690                 695                 700                 


Thr Pro His Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Phe Arg Pro 
705                 710                 715                 720 


Glu Gln Glu Thr Ser Asp Pro Ala Ala His Ala Leu Tyr Pro Gly Gln 
                725                 730                 735     


Leu Val Gln Leu Met Leu Thr Asn Phe Thr Ser Leu Phe Pro 
            740                 745                 750 


<210>  69
<211>  1578
<212>  DNA
<213>  Homo sapiens

<400>  69
atgaaggcac tcattgcagc actgcttttg atcacattgc agtattcgtg tgccgtgagt       60

cccactgact gcagtgctgt tgagccggag gctgagaaag ctctagacct gatcaataaa      120

aggcgacggg atggctacct tttccaattg ctgcggattg ctgatgccca cttggacaga      180

gtggaaaata caactgtata ttacttagtc ttagatgtgc aagaatcgga ctgttcggtc      240

ctatccagga aatactggaa tgactgtgag ccacctgatt ccagacgtcc atctgaaata      300

gtgatcggac aatgtaaggt aatagctaca agacattccc atgaatctca ggacctcaga      360

gtgattgact ttaactgcac cacaagttct gtctcttcag cactggccaa taccaaagat      420

agtccggtcc tcatagattt ctttgaggat actgagcgct acagaaaaca agccaacaaa      480

gcccttgaga agtacaaaga ggagaatgat gactttgcct ctttcagagt ggaccgaatc      540

gagagagttg caagagtgag aggaggggaa ggaactggtt acttcgtgga cttctctgtg      600

cggaactgcc ccagacacca tttccccaga caccccaatg tctttggatt ctgcagagca      660

gatttgttct atgatgtaga agccttggac ttggaaagcc cgaaaaacct tgtcataaac      720

tgtgaagtct tcgaccctca ggaacatgag aacatcaatg gtgtaccgcc tcatttggga      780

catcccttcc actggggtgg gcatgagcgt tcttctacca ccaagcctcc attcaagccc      840

catggatcta gagatcatca tcatccccac aagccacacg aacatggacc cccacctcct      900

ccagatgaaa gagatcactc acatggaccc ccacttccac aaggccctcc tccactattg      960

cccatgtcct gctcaagttg tcaacatgcc acttttggca caaatggggc ccaaagacat     1020

tctcataata ataattccag tgacctccat ccccataagc atcattccca tgaacagcat     1080

ccccatggac accatcccca tgcacaccat cctcatgaac atgataccca tagacagcat     1140

ccccatggac accaccccca tggacaccat cctcatggac accaccccca tggacaccat     1200

ccccatggac accatcccca ctgccatgat ttccaagact atggaccttg tgacccacca     1260

ccccataacc aaggtcactg ttgccatggc cacggcccac cacctgggca cttaagaagg     1320

cgaggcccag gtaaaggacc ccgtcccttc cattgcagac aaattggatc tgtgtaccga     1380

ctccctcctc taagaaaagg tgaggtgctg ccacttcctg aggccaattt tcccagcttc     1440

ccattgccgc accacaaaca tcctctaaag ccagacaatc agccctttcc tcaatcagtc     1500

tctgaatcat gtccagggaa gttcaagagt gggtttccac aagtttccat gttttttaca     1560

catacatttc caaaataa                                                   1578


<210>  70
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  71
<211>  4959
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaaaaagg aaggctcttc aggttccttc agactccagc cgaatacagg ttctctctca       60

cgtgctgtaa gttggataaa tttctcctcc ttgtccaggc agacaaagag gctgtttcgc      120

agtgatggag agctctcggt ttgtgggcag caggtggaag tggatgacga aaactggata      180

tacagagccc agcccagaaa agcggtttcc aacctagatg aggaaagccg atggacagtc      240

cactacactg ccccgtggca ccagcaggag aatgtgttcc ttcccaccac aagacccccc      300

tgtgttgagg acctgcaccg ccaagccaag ctcaacctca aatcagtact gagggaatgc      360

gataagttgc ggcatgatgg ctaccgcagt tctcagtact actctcaggg acccaccttt      420

gcggccaacg ccagcccatt ctgtgatgat taccaagatg aagatgaaga aacagatcaa      480

aagtgttctc tgtcttcatc agaagaagaa agatttattt ccatcaggag acctaaaaca      540

ccagcctcaa gtgacttctc cgaccttaat actcagacga actggaccaa gtcgcttcca      600

ctgccaacac cagaagagaa gatgcgacag caagcccaaa cagtccaggc tgacgtggtg      660

cctattaaca taactgcatc aggcactggc caagatgatg ctgatggcca ctcagtgtac      720

acccctgatc actactctac actaggaagg ttcaatagct gtcggtctgc tgggcagcgc      780

tcagaaacca gggactccag ctgtcagacg gaggatgtga aggtcgtacc accttccatg      840

aggagaatca gggcacagaa ggggcaaggc attgctgccc agatgggcca cttctcaggt      900

tcctctggca acatgtctgt gctgagcgat tctgcaggga tcgtattccc ttcccgcctt      960

gacagtgatg ctggcttcca tagtcttccg cgttctggag caagggcaaa cattcagtcc     1020

cttgagccga ggctgggtgc cctcggccct gcaggagaca tgaatggcac tttcctctac     1080

cagagaggtc acccacaagc agatgaaaac ttaggccatt taggaggtgc ctcagggact     1140

ggaacacttt tgagacccaa atcccaggag ttgagacact tcgagagtga aaatataatg     1200

agcccagcgt gtgtggtttc tcctcatgca acctactcca ccagcatcat cccaaatgcc     1260

acactgtctt cctcttccga ggtcatcgct attcccactg ctcagagtgc gggacagcgg     1320

gaaagtaaaa gttctggctc atcacatgca aggataaaat ccagagacca cctcatctcc     1380

aggcatgctg tgaaaggtga tcctcagtct cccggtcgcc actggaatga gggccatgcc     1440

accattcttt cacaggactt agaccctcat tcccctggtg aacccgcact gttgtccctc     1500

tgtgactcag ccgtccctct aaatgctcca gcaaataggg agaatgggtc ccaagctatg     1560

ccgtataatt gtagaaacaa cctggccttc ccagcccacc cccaagatgt ggatggcaag     1620

agtgaatcta gttattcagg gggcggaggg cacagcagct cggagccctg ggaatacaaa     1680

tcctcaggta atggaagggc atcccccctg aagccgcatt tagcaactcc tggctattcc     1740

actcccacaa gtaacatgag cagctgcagt ttggaccaaa cgtccaacaa agaggatgct     1800

gggtcgctgt attctgagga ccacgatggc tactgtgcat ctgtgcacac tgactctgga     1860

catggatctg ggaatctgtg caatagcagt gatggctttg ggaaccccag gcacagcgtg     1920

atcaatgttt ttgttggaag agctcagaaa aaccaagggg accggtccaa ttaccaggat     1980

aaatccctat caagaaacat ctctttgaag aaagcaaaga agcctcccct gccaccctcc     2040

cggacagact ccctccgcag gattcccaag aagagcagcc agtgcaacgg gcaggtgctc     2100

aacgagagcc tgatcgccac actccagcac tcgctgcagc tgagcctccc aggcaagagt     2160

ggcagctcgc cctcccagag cccctgcagt gacttggaag agccctggct gccccgctcc     2220

cggagccaga gcacagttag tgctggcagc agcatgactt ccgccaccac ccccaatgtc     2280

tactccctgt gcggggccac gccatcgcag agtgacacaa gcagcgtcaa gtcagagtac     2340

acggacccct ggggttatta cattgactac acgggcatgc aggaagatcc ggggaacccg     2400

gcagggggct gttcaaccag cagtggggtg cccactggga acgggccagt ccgccatgtc     2460

caagaagggt ccagagccac aatgccccaa gtgcccggtg gttcagtcaa accaaagatc     2520

atgtcaccag agaagtcaca cagagtcatt tctccatcca gtgggtattc cagccagtcg     2580

aatacaccca cagcactcac ccctgtgcct gtgtttttaa aatcagtgtc accagcaaac     2640

gggaagggga agcccaagcc caaggtacca gaaaggaagt cctctctgat atcttcagta     2700

tccatttcct catcgtccac ttctctttct tctagtactt ctactgaagg aagtggcact     2760

atgaagaagc tggatccagc cgtgggctct cccccggctc ctcctcctcc tcctgttccc     2820

tctcctccat tcccttgtcc tgcagacagg tctcctttcc ttcctccccc acctcctgtc     2880

acagattgct cccagggctc tcctctgcct cactctcctg tgttcccccc tccgccgcca     2940

gaagctctca ttcctttctg ctccccacct gattggtgcc tttctcctcc ccgccctgca     3000

ctgagcccca ttcttccaga ttcacctgtg tccttgccat tgcccccacc tctcttacct     3060

tcctcggaac ccccacctgc cccacctctt gaccccaaat tcatgaaaga caccaggccg     3120

cctttcacaa attctggcca gccagaatcc tcccggggat ccttgaggcc gccttctacc     3180

aaggaggaga ccagcaggcc ccccatgccc ctgataacca cggaagcatt gcagatggtg     3240

cagttgaggc ccgtgagaaa gaactcaggc gctgaggcgg cacagttgtc tgaacgaaca     3300

gctcaggaac aacgaactcc agttgctcca cagtaccact taaagccatc tgctttcctg     3360

aaatcccgaa atagcacaaa tgaaatggag agtgaaagcc agcctgcctc tgtgacaagc     3420

tcgcttccga cgcctgccaa gagctcgagt cagggtgacc atggcagtgc ggctgagcgt     3480

ggtggccctg tgagccgcag ccctggagct ccaagcgctg gggaggcaga ggctcggccc     3540

agccccagca ccaccccact cccagactct tcacccagca ggaagccacc ccccatttcc     3600

aagaagccca aactgttcct ggtggtacca cctccgcaga aagattttgc agtggagccc     3660

gcagagaacg tgagcgaagc cctccgagct gtgcccagcc ccacgacggg agaggagggc     3720

tctgtgcaca gcagggaggc aaaagagagt tctgcagccc aagctggctc tcatgccacg     3780

caccctggca cctcggttct tgagggagga gctgcaggat ccatgtctcc cagcagagtg     3840

gaagccaatg tccccatggt tcagcctgat gtctcaccag cccccaagca ggaggagcca     3900

gccgagaaca gtgcggatac tgggggcgat ggggagagct gcctatctca acaggacgga     3960

gcaggtgagt ctggcttcct ggcttctctc tcctgtgccc tctgcccata tgcagctgaa     4020

ccagataggg ttgttgaatg ctcacacgtg gaaagaaccc aggtagatca gattcctgtt     4080

aaagctagca ctggggtgcc ggagaccaac gcagccggtt catcctcaga ggcctgtgac     4140

ttcctcaagg aagacgggaa tgatgaggta atgaccccca gtcgacccag gaccacagaa     4200

gacctttttg cagctattca cagatccaaa aggaaagtcc tcggccgtag agattcagat     4260

gatgaccact cccgaaacca ttctccctcc ccgcccgtga cacccaccgg cgctgcccca     4320

agcctggcct ctccaaagca agtggggtcg attcagagaa gcatccgaaa gagcagcacc     4380

agcagtgaca acttcaaagc tctgctgctg aaaaagggca gtcgttcaga caccagcgcc     4440

cgcatgtctg cagcagagat gctcaagaac acagacccta gattccagag gtcgaggtca     4500

gagccttccc cagatgcccc cgagagcccg tcaagctgct ccccaagcaa gaacagaagg     4560

gcgcaggagg agtgggccaa gaacgaaggc ttgatgcctc ggagtctgtc cttttccggc     4620

cccaggtacg gccgcagccg aacgccgcct tctgccgcca gcagcaggta cagcatgcgg     4680

aaccggatcc agagcagccc catgaccgtc atctcggagg gagaagggga agccgtggag     4740

cctgtggaca gcatagcccg cggggctctg ggcgctgcgg agggatgttc cctggacgga     4800

ctggcgaggg aggagatgga cgagggcggc ctgctctgtg gggaggggcc tgccgcctcc     4860

ctgcagcccc aggcccccgg ccctgtggat gggacagcca gtgcagaggg cagagagccc     4920

tccccacagt gtggcggttc tctgagcgag gagagttag                            4959


<210>  72
<211>  1652
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Lys Lys Glu Gly Ser Ser Gly Ser Phe Arg Leu Gln Pro Asn Thr 
1               5                   10                  15      


Gly Ser Leu Ser Arg Ala Val Ser Trp Ile Asn Phe Ser Ser Leu Ser 
            20                  25                  30          


Arg Gln Thr Lys Arg Leu Phe Arg Ser Asp Gly Glu Leu Ser Val Cys 
        35                  40                  45              


Gly Gln Gln Val Glu Val Asp Asp Glu Asn Trp Ile Tyr Arg Ala Gln 
    50                  55                  60                  


Pro Arg Lys Ala Val Ser Asn Leu Asp Glu Glu Ser Arg Trp Thr Val 
65                  70                  75                  80  


His Tyr Thr Ala Pro Trp His Gln Gln Glu Asn Val Phe Leu Pro Thr 
                85                  90                  95      


Thr Arg Pro Pro Cys Val Glu Asp Leu His Arg Gln Ala Lys Leu Asn 
            100                 105                 110         


Leu Lys Ser Val Leu Arg Glu Cys Asp Lys Leu Arg His Asp Gly Tyr 
        115                 120                 125             


Arg Ser Ser Gln Tyr Tyr Ser Gln Gly Pro Thr Phe Ala Ala Asn Ala 
    130                 135                 140                 


Ser Pro Phe Cys Asp Asp Tyr Gln Asp Glu Asp Glu Glu Thr Asp Gln 
145                 150                 155                 160 


Lys Cys Ser Leu Ser Ser Ser Glu Glu Glu Arg Phe Ile Ser Ile Arg 
                165                 170                 175     


Arg Pro Lys Thr Pro Ala Ser Ser Asp Phe Ser Asp Leu Asn Thr Gln 
            180                 185                 190         


Thr Asn Trp Thr Lys Ser Leu Pro Leu Pro Thr Pro Glu Glu Lys Met 
        195                 200                 205             


Arg Gln Gln Ala Gln Thr Val Gln Ala Asp Val Val Pro Ile Asn Ile 
    210                 215                 220                 


Thr Ala Ser Gly Thr Gly Gln Asp Asp Ala Asp Gly His Ser Val Tyr 
225                 230                 235                 240 


Thr Pro Asp His Tyr Ser Thr Leu Gly Arg Phe Asn Ser Cys Arg Ser 
                245                 250                 255     


Ala Gly Gln Arg Ser Glu Thr Arg Asp Ser Ser Cys Gln Thr Glu Asp 
            260                 265                 270         


Val Lys Val Val Pro Pro Ser Met Arg Arg Ile Arg Ala Gln Lys Gly 
        275                 280                 285             


Gln Gly Ile Ala Ala Gln Met Gly His Phe Ser Gly Ser Ser Gly Asn 
    290                 295                 300                 


Met Ser Val Leu Ser Asp Ser Ala Gly Ile Val Phe Pro Ser Arg Leu 
305                 310                 315                 320 


Asp Ser Asp Ala Gly Phe His Ser Leu Pro Arg Ser Gly Ala Arg Ala 
                325                 330                 335     


Asn Ile Gln Ser Leu Glu Pro Arg Leu Gly Ala Leu Gly Pro Ala Gly 
            340                 345                 350         


Asp Met Asn Gly Thr Phe Leu Tyr Gln Arg Gly His Pro Gln Ala Asp 
        355                 360                 365             


Glu Asn Leu Gly His Leu Gly Gly Ala Ser Gly Thr Gly Thr Leu Leu 
    370                 375                 380                 


Arg Pro Lys Ser Gln Glu Leu Arg His Phe Glu Ser Glu Asn Ile Met 
385                 390                 395                 400 


Ser Pro Ala Cys Val Val Ser Pro His Ala Thr Tyr Ser Thr Ser Ile 
                405                 410                 415     


Ile Pro Asn Ala Thr Leu Ser Ser Ser Ser Glu Val Ile Ala Ile Pro 
            420                 425                 430         


Thr Ala Gln Ser Ala Gly Gln Arg Glu Ser Lys Ser Ser Gly Ser Ser 
        435                 440                 445             


His Ala Arg Ile Lys Ser Arg Asp His Leu Ile Ser Arg His Ala Val 
    450                 455                 460                 


Lys Gly Asp Pro Gln Ser Pro Gly Arg His Trp Asn Glu Gly His Ala 
465                 470                 475                 480 


Thr Ile Leu Ser Gln Asp Leu Asp Pro His Ser Pro Gly Glu Pro Ala 
                485                 490                 495     


Leu Leu Ser Leu Cys Asp Ser Ala Val Pro Leu Asn Ala Pro Ala Asn 
            500                 505                 510         


Arg Glu Asn Gly Ser Gln Ala Met Pro Tyr Asn Cys Arg Asn Asn Leu 
        515                 520                 525             


Ala Phe Pro Ala His Pro Gln Asp Val Asp Gly Lys Ser Glu Ser Ser 
    530                 535                 540                 


Tyr Ser Gly Gly Gly Gly His Ser Ser Ser Glu Pro Trp Glu Tyr Lys 
545                 550                 555                 560 


Ser Ser Gly Asn Gly Arg Ala Ser Pro Leu Lys Pro His Leu Ala Thr 
                565                 570                 575     


Pro Gly Tyr Ser Thr Pro Thr Ser Asn Met Ser Ser Cys Ser Leu Asp 
            580                 585                 590         


Gln Thr Ser Asn Lys Glu Asp Ala Gly Ser Leu Tyr Ser Glu Asp His 
        595                 600                 605             


Asp Gly Tyr Cys Ala Ser Val His Thr Asp Ser Gly His Gly Ser Gly 
    610                 615                 620                 


Asn Leu Cys Asn Ser Ser Asp Gly Phe Gly Asn Pro Arg His Ser Val 
625                 630                 635                 640 


Ile Asn Val Phe Val Gly Arg Ala Gln Lys Asn Gln Gly Asp Arg Ser 
                645                 650                 655     


Asn Tyr Gln Asp Lys Ser Leu Ser Arg Asn Ile Ser Leu Lys Lys Ala 
            660                 665                 670         


Lys Lys Pro Pro Leu Pro Pro Ser Arg Thr Asp Ser Leu Arg Arg Ile 
        675                 680                 685             


Pro Lys Lys Ser Ser Gln Cys Asn Gly Gln Val Leu Asn Glu Ser Leu 
    690                 695                 700                 


Ile Ala Thr Leu Gln His Ser Leu Gln Leu Ser Leu Pro Gly Lys Ser 
705                 710                 715                 720 


Gly Ser Ser Pro Ser Gln Ser Pro Cys Ser Asp Leu Glu Glu Pro Trp 
                725                 730                 735     


Leu Pro Arg Ser Arg Ser Gln Ser Thr Val Ser Ala Gly Ser Ser Met 
            740                 745                 750         


Thr Ser Ala Thr Thr Pro Asn Val Tyr Ser Leu Cys Gly Ala Thr Pro 
        755                 760                 765             


Ser Gln Ser Asp Thr Ser Ser Val Lys Ser Glu Tyr Thr Asp Pro Trp 
    770                 775                 780                 


Gly Tyr Tyr Ile Asp Tyr Thr Gly Met Gln Glu Asp Pro Gly Asn Pro 
785                 790                 795                 800 


Ala Gly Gly Cys Ser Thr Ser Ser Gly Val Pro Thr Gly Asn Gly Pro 
                805                 810                 815     


Val Arg His Val Gln Glu Gly Ser Arg Ala Thr Met Pro Gln Val Pro 
            820                 825                 830         


Gly Gly Ser Val Lys Pro Lys Ile Met Ser Pro Glu Lys Ser His Arg 
        835                 840                 845             


Val Ile Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Asn Thr Pro Thr 
    850                 855                 860                 


Ala Leu Thr Pro Val Pro Val Phe Leu Lys Ser Val Ser Pro Ala Asn 
865                 870                 875                 880 


Gly Lys Gly Lys Pro Lys Pro Lys Val Pro Glu Arg Lys Ser Ser Leu 
                885                 890                 895     


Ile Ser Ser Val Ser Ile Ser Ser Ser Ser Thr Ser Leu Ser Ser Ser 
            900                 905                 910         


Thr Ser Thr Glu Gly Ser Gly Thr Met Lys Lys Leu Asp Pro Ala Val 
        915                 920                 925             


Gly Ser Pro Pro Ala Pro Pro Pro Pro Pro Val Pro Ser Pro Pro Phe 
    930                 935                 940                 


Pro Cys Pro Ala Asp Arg Ser Pro Phe Leu Pro Pro Pro Pro Pro Val 
945                 950                 955                 960 


Thr Asp Cys Ser Gln Gly Ser Pro Leu Pro His Ser Pro Val Phe Pro 
                965                 970                 975     


Pro Pro Pro Pro Glu Ala Leu Ile Pro Phe Cys Ser Pro Pro Asp Trp 
            980                 985                 990         


Cys Leu Ser Pro Pro Arg Pro Ala  Leu Ser Pro Ile Leu  Pro Asp Ser 
        995                 1000                 1005             


Pro Val  Ser Leu Pro Leu Pro  Pro Pro Leu Leu Pro  Ser Ser Glu 
    1010                 1015                 1020             


Pro Pro  Pro Ala Pro Pro Leu  Asp Pro Lys Phe Met  Lys Asp Thr 
    1025                 1030                 1035             


Arg Pro  Pro Phe Thr Asn Ser  Gly Gln Pro Glu Ser  Ser Arg Gly 
    1040                 1045                 1050             


Ser Leu  Arg Pro Pro Ser Thr  Lys Glu Glu Thr Ser  Arg Pro Pro 
    1055                 1060                 1065             


Met Pro  Leu Ile Thr Thr Glu  Ala Leu Gln Met Val  Gln Leu Arg 
    1070                 1075                 1080             


Pro Val  Arg Lys Asn Ser Gly  Ala Glu Ala Ala Gln  Leu Ser Glu 
    1085                 1090                 1095             


Arg Thr  Ala Gln Glu Gln Arg  Thr Pro Val Ala Pro  Gln Tyr His 
    1100                 1105                 1110             


Leu Lys  Pro Ser Ala Phe Leu  Lys Ser Arg Asn Ser  Thr Asn Glu 
    1115                 1120                 1125             


Met Glu  Ser Glu Ser Gln Pro  Ala Ser Val Thr Ser  Ser Leu Pro 
    1130                 1135                 1140             


Thr Pro  Ala Lys Ser Ser Ser  Gln Gly Asp His Gly  Ser Ala Ala 
    1145                 1150                 1155             


Glu Arg  Gly Gly Pro Val Ser  Arg Ser Pro Gly Ala  Pro Ser Ala 
    1160                 1165                 1170             


Gly Glu  Ala Glu Ala Arg Pro  Ser Pro Ser Thr Thr  Pro Leu Pro 
    1175                 1180                 1185             


Asp Ser  Ser Pro Ser Arg Lys  Pro Pro Pro Ile Ser  Lys Lys Pro 
    1190                 1195                 1200             


Lys Leu  Phe Leu Val Val Pro  Pro Pro Gln Lys Asp  Phe Ala Val 
    1205                 1210                 1215             


Glu Pro  Ala Glu Asn Val Ser  Glu Ala Leu Arg Ala  Val Pro Ser 
    1220                 1225                 1230             


Pro Thr  Thr Gly Glu Glu Gly  Ser Val His Ser Arg  Glu Ala Lys 
    1235                 1240                 1245             


Glu Ser  Ser Ala Ala Gln Ala  Gly Ser His Ala Thr  His Pro Gly 
    1250                 1255                 1260             


Thr Ser  Val Leu Glu Gly Gly  Ala Ala Gly Ser Met  Ser Pro Ser 
    1265                 1270                 1275             


Arg Val  Glu Ala Asn Val Pro  Met Val Gln Pro Asp  Val Ser Pro 
    1280                 1285                 1290             


Ala Pro  Lys Gln Glu Glu Pro  Ala Glu Asn Ser Ala  Asp Thr Gly 
    1295                 1300                 1305             


Gly Asp  Gly Glu Ser Cys Leu  Ser Gln Gln Asp Gly  Ala Gly Glu 
    1310                 1315                 1320             


Ser Gly  Phe Leu Ala Ser Leu  Ser Cys Ala Leu Cys  Pro Tyr Ala 
    1325                 1330                 1335             


Ala Glu  Pro Asp Arg Val Val  Glu Cys Ser His Val  Glu Arg Thr 
    1340                 1345                 1350             


Gln Val  Asp Gln Ile Pro Val  Lys Ala Ser Thr Gly  Val Pro Glu 
    1355                 1360                 1365             


Thr Asn  Ala Ala Gly Ser Ser  Ser Glu Ala Cys Asp  Phe Leu Lys 
    1370                 1375                 1380             


Glu Asp  Gly Asn Asp Glu Val  Met Thr Pro Ser Arg  Pro Arg Thr 
    1385                 1390                 1395             


Thr Glu  Asp Leu Phe Ala Ala  Ile His Arg Ser Lys  Arg Lys Val 
    1400                 1405                 1410             


Leu Gly  Arg Arg Asp Ser Asp  Asp Asp His Ser Arg  Asn His Ser 
    1415                 1420                 1425             


Pro Ser  Pro Pro Val Thr Pro  Thr Gly Ala Ala Pro  Ser Leu Ala 
    1430                 1435                 1440             


Ser Pro  Lys Gln Val Gly Ser  Ile Gln Arg Ser Ile  Arg Lys Ser 
    1445                 1450                 1455             


Ser Thr  Ser Ser Asp Asn Phe  Lys Ala Leu Leu Leu  Lys Lys Gly 
    1460                 1465                 1470             


Ser Arg  Ser Asp Thr Ser Ala  Arg Met Ser Ala Ala  Glu Met Leu 
    1475                 1480                 1485             


Lys Asn  Thr Asp Pro Arg Phe  Gln Arg Ser Arg Ser  Glu Pro Ser 
    1490                 1495                 1500             


Pro Asp  Ala Pro Glu Ser Pro  Ser Ser Cys Ser Pro  Ser Lys Asn 
    1505                 1510                 1515             


Arg Arg  Ala Gln Glu Glu Trp  Ala Lys Asn Glu Gly  Leu Met Pro 
    1520                 1525                 1530             


Arg Ser  Leu Ser Phe Ser Gly  Pro Arg Tyr Gly Arg  Ser Arg Thr 
    1535                 1540                 1545             


Pro Pro  Ser Ala Ala Ser Ser  Arg Tyr Ser Met Arg  Asn Arg Ile 
    1550                 1555                 1560             


Gln Ser  Ser Pro Met Thr Val  Ile Ser Glu Gly Glu  Gly Glu Ala 
    1565                 1570                 1575             


Val Glu  Pro Val Asp Ser Ile  Ala Arg Gly Ala Leu  Gly Ala Ala 
    1580                 1585                 1590             


Glu Gly  Cys Ser Leu Asp Gly  Leu Ala Arg Glu Glu  Met Asp Glu 
    1595                 1600                 1605             


Gly Gly  Leu Leu Cys Gly Glu  Gly Pro Ala Ala Ser  Leu Gln Pro 
    1610                 1615                 1620             


Gln Ala  Pro Gly Pro Val Asp  Gly Thr Ala Ser Ala  Glu Gly Arg 
    1625                 1630                 1635             


Glu Pro  Ser Pro Gln Cys Gly  Gly Ser Leu Ser Glu  Glu Ser 
    1640                 1645                 1650         


<210>  73
<211>  2268
<212>  DNA
<213>  Homo sapiens

<400>  73
atgccccctt tcctgttgct ggaagccgtc tgtgttttcc tgttttccag agtgccccca       60

tctctccctc tccaggaagt ccatgtaagc aaagaaacca tcgggaagat ttcagctgcc      120

agcaaaatga tgtggtgctc ggctgcagtg gacatcatgt ttctgttaga tgggtctaac      180

agcgtcggga aagggagctt tgaaaggtcc aagcactttg ccatcacagt ctgtgacggt      240

ctggacatca gccccgagag ggtcagagtg ggagcattcc agttcagttc cactcctcat      300

ctggaattcc ccttggattc attttcaacc caacaggaag tgaaggcaag aatcaagagg      360

atggttttca aaggagggcg cacggagacg gaacttgctc tgaaatacct tctgcacaga      420

gggttgcctg gaggcagaaa tgcttctgtg ccccagatcc tcatcatcgt cactgatggg      480

aagtcccagg gggatgtggc actgccatcc aagcagctga aggaaagggg tgtcactgtg      540

tttgctgtgg gggtcaggtt tcccaggtgg gaggagctgc atgcactggc cagcgagcct      600

agagggcagc acgtgctgtt ggctgagcag gtggaggatg ccaccaacgg cctcttcagc      660

accctcagca gctcggccat ctgctccagc gccacgccag actgcagggt cgaggctcac      720

ccctgtgagc acaggacgct ggagatggtc cgggagttcg ctggcaatgc cccatgctgg      780

agaggatcgc ggcggaccct tgcggtgctg gctgcacact gtcccttcta cagctggaag      840

agagtgttcc taacccaccc tgccacctgc tacaggacca cctgcccagg cccctgtgac      900

tcgcagccct gccagaatgg aggcacatgt gttccagaag gactggacgg ctaccagtgc      960

ctctgcccgc tggcctttgg aggggaggct aactgtgccc tgaagctgag cctggaatgc     1020

agggtcgacc tcctcttcct gctggacagc tctgcgggca ccactctgga cggcttcctg     1080

cgggccaaag tcttcgtgaa gcggtttgtg cgggccgtgc tgagcgagga ctctcgggcc     1140

cgagtgggtg tggccacata cagcagggag ctgctggtgg cggtgcctgt gggggagtac     1200

caggatgtgc ctgacctggt ctggagcctc gatggcattc ccttccgtgg tggccccacc     1260

ctgacgggca gtgccttgcg gcaggcggca gagcgtggct tcgggagcgc caccaggaca     1320

ggccaggacc ggccacgtag agtggtggtt ttgctcactg agtcacactc cgaggatgag     1380

gttgcgggcc cagcgcgtca cgcaagggcg cgagagctgc tcctgctggg tgtaggcagt     1440

gaggccgtgc gggcagagct ggaggagatc acaggcagcc caaagcatgt gatggtctac     1500

tcggatcctc aggatctgtt caaccaaatc cctgagctgc aggggaagct gtgcagccgg     1560

cagcggccag ggtgccggac acaagccctg gacctcgtct tcatgttgga cacctctgcc     1620

tcagtagggc ccgagaattt tgctcagatg cagagctttg tgagaagctg tgccctccag     1680

tttgaggtga accctgacgt gacacaggtc ggcctggtgg tgtatggcag ccaggtgcag     1740

actgccttcg ggctggacac caaacccacc cgggctgcga tgctgcgggc cattagccag     1800

gccccctacc taggtggggt gggctcagcc ggcaccgccc tgctgcacat ctatgacaaa     1860

gtgatgaccg tccagagggg tgcccggcct ggtgtcccca aagctgtggt ggtgctcaca     1920

ggcgggagag gcgcagagga tgcagccgtt cctgcccaga agctgaggaa caatggcatc     1980

tctgtcttgg tcgtgggcgt ggggcctgtc ctaagtgagg gtctgcggag gcttgcaggt     2040

ccccgggatt ccctgatcca cgtggcagct tacgccgacc tgcggtacca ccaggacgtg     2100

ctcattgagt ggctgtgtgg agaagccaag cagccagtca acctctgcaa acccagcccg     2160

tgcatgaatg agggcagctg cgtcctgcag aatgggagct accgctgcaa gtgtcgggat     2220

ggctgggagg gcccccactg cgagaaccga ttcttgagac gcccctga                  2268


<210>  74
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Pro Phe Leu Leu Leu Glu Ala Val Cys Val Phe Leu Phe Ser 
1               5                   10                  15      


Arg Val Pro Pro Ser Leu Pro Leu Gln Glu Val His Val Ser Lys Glu 
            20                  25                  30          


Thr Ile Gly Lys Ile Ser Ala Ala Ser Lys Met Met Trp Cys Ser Ala 
        35                  40                  45              


Ala Val Asp Ile Met Phe Leu Leu Asp Gly Ser Asn Ser Val Gly Lys 
    50                  55                  60                  


Gly Ser Phe Glu Arg Ser Lys His Phe Ala Ile Thr Val Cys Asp Gly 
65                  70                  75                  80  


Leu Asp Ile Ser Pro Glu Arg Val Arg Val Gly Ala Phe Gln Phe Ser 
                85                  90                  95      


Ser Thr Pro His Leu Glu Phe Pro Leu Asp Ser Phe Ser Thr Gln Gln 
            100                 105                 110         


Glu Val Lys Ala Arg Ile Lys Arg Met Val Phe Lys Gly Gly Arg Thr 
        115                 120                 125             


Glu Thr Glu Leu Ala Leu Lys Tyr Leu Leu His Arg Gly Leu Pro Gly 
    130                 135                 140                 


Gly Arg Asn Ala Ser Val Pro Gln Ile Leu Ile Ile Val Thr Asp Gly 
145                 150                 155                 160 


Lys Ser Gln Gly Asp Val Ala Leu Pro Ser Lys Gln Leu Lys Glu Arg 
                165                 170                 175     


Gly Val Thr Val Phe Ala Val Gly Val Arg Phe Pro Arg Trp Glu Glu 
            180                 185                 190         


Leu His Ala Leu Ala Ser Glu Pro Arg Gly Gln His Val Leu Leu Ala 
        195                 200                 205             


Glu Gln Val Glu Asp Ala Thr Asn Gly Leu Phe Ser Thr Leu Ser Ser 
    210                 215                 220                 


Ser Ala Ile Cys Ser Ser Ala Thr Pro Asp Cys Arg Val Glu Ala His 
225                 230                 235                 240 


Pro Cys Glu His Arg Thr Leu Glu Met Val Arg Glu Phe Ala Gly Asn 
                245                 250                 255     


Ala Pro Cys Trp Arg Gly Ser Arg Arg Thr Leu Ala Val Leu Ala Ala 
            260                 265                 270         


His Cys Pro Phe Tyr Ser Trp Lys Arg Val Phe Leu Thr His Pro Ala 
        275                 280                 285             


Thr Cys Tyr Arg Thr Thr Cys Pro Gly Pro Cys Asp Ser Gln Pro Cys 
    290                 295                 300                 


Gln Asn Gly Gly Thr Cys Val Pro Glu Gly Leu Asp Gly Tyr Gln Cys 
305                 310                 315                 320 


Leu Cys Pro Leu Ala Phe Gly Gly Glu Ala Asn Cys Ala Leu Lys Leu 
                325                 330                 335     


Ser Leu Glu Cys Arg Val Asp Leu Leu Phe Leu Leu Asp Ser Ser Ala 
            340                 345                 350         


Gly Thr Thr Leu Asp Gly Phe Leu Arg Ala Lys Val Phe Val Lys Arg 
        355                 360                 365             


Phe Val Arg Ala Val Leu Ser Glu Asp Ser Arg Ala Arg Val Gly Val 
    370                 375                 380                 


Ala Thr Tyr Ser Arg Glu Leu Leu Val Ala Val Pro Val Gly Glu Tyr 
385                 390                 395                 400 


Gln Asp Val Pro Asp Leu Val Trp Ser Leu Asp Gly Ile Pro Phe Arg 
                405                 410                 415     


Gly Gly Pro Thr Leu Thr Gly Ser Ala Leu Arg Gln Ala Ala Glu Arg 
            420                 425                 430         


Gly Phe Gly Ser Ala Thr Arg Thr Gly Gln Asp Arg Pro Arg Arg Val 
        435                 440                 445             


Val Val Leu Leu Thr Glu Ser His Ser Glu Asp Glu Val Ala Gly Pro 
    450                 455                 460                 


Ala Arg His Ala Arg Ala Arg Glu Leu Leu Leu Leu Gly Val Gly Ser 
465                 470                 475                 480 


Glu Ala Val Arg Ala Glu Leu Glu Glu Ile Thr Gly Ser Pro Lys His 
                485                 490                 495     


Val Met Val Tyr Ser Asp Pro Gln Asp Leu Phe Asn Gln Ile Pro Glu 
            500                 505                 510         


Leu Gln Gly Lys Leu Cys Ser Arg Gln Arg Pro Gly Cys Arg Thr Gln 
        515                 520                 525             


Ala Leu Asp Leu Val Phe Met Leu Asp Thr Ser Ala Ser Val Gly Pro 
    530                 535                 540                 


Glu Asn Phe Ala Gln Met Gln Ser Phe Val Arg Ser Cys Ala Leu Gln 
545                 550                 555                 560 


Phe Glu Val Asn Pro Asp Val Thr Gln Val Gly Leu Val Val Tyr Gly 
                565                 570                 575     


Ser Gln Val Gln Thr Ala Phe Gly Leu Asp Thr Lys Pro Thr Arg Ala 
            580                 585                 590         


Ala Met Leu Arg Ala Ile Ser Gln Ala Pro Tyr Leu Gly Gly Val Gly 
        595                 600                 605             


Ser Ala Gly Thr Ala Leu Leu His Ile Tyr Asp Lys Val Met Thr Val 
    610                 615                 620                 


Gln Arg Gly Ala Arg Pro Gly Val Pro Lys Ala Val Val Val Leu Thr 
625                 630                 635                 640 


Gly Gly Arg Gly Ala Glu Asp Ala Ala Val Pro Ala Gln Lys Leu Arg 
                645                 650                 655     


Asn Asn Gly Ile Ser Val Leu Val Val Gly Val Gly Pro Val Leu Ser 
            660                 665                 670         


Glu Gly Leu Arg Arg Leu Ala Gly Pro Arg Asp Ser Leu Ile His Val 
        675                 680                 685             


Ala Ala Tyr Ala Asp Leu Arg Tyr His Gln Asp Val Leu Ile Glu Trp 
    690                 695                 700                 


Leu Cys Gly Glu Ala Lys Gln Pro Val Asn Leu Cys Lys Pro Ser Pro 
705                 710                 715                 720 


Cys Met Asn Glu Gly Ser Cys Val Leu Gln Asn Gly Ser Tyr Arg Cys 
                725                 730                 735     


Lys Cys Arg Asp Gly Trp Glu Gly Pro His Cys Glu Asn Arg Phe Leu 
            740                 745                 750         


Arg Arg Pro 
        755 


<210>  75
<211>  6390
<212>  DNA
<213>  Homo sapiens

<400>  75
atggccgagc gccgcgcctt cgcccagaag atcagcagaa cggtggcagc cgaagttagg       60

aagcagatct ccggacaata tagtggttct ccccaactgc tcaaaaacct taatattgtt      120

ggcaatatat cccatcacac cacagtgccc cttaccgaag cagtagatcc agtggatttg      180

gaagattacc tcattactca tcctttggct gtggattctg ggcctttacg ggatttgatt      240

gaatttcctc cagatgatat tgaagttgtt tatagtcctc gggactgcag aactcttgtt      300

tcagctgtac ctgaagaaag tgaaatggat ccacatgtta gagactgtat aagaagttat      360

acagaagact gggcaattgt catcagaaaa tatcataaat tgggaacagg atttaatccc      420

aatacattag ataaacagaa agaaaggcaa aaaggtttgc caaaacaagt ttttgaatct      480

gatgaagctc cagatggcaa cagctaccag gatgatcaag atgaccttaa aagacgttca      540

atgtcaatag atgatacccc aaggggtagc tgggcctgta gtatctttga cttgaaaaat      600

tcacttcctg atgctttgct tcccaattta cttgatcgaa ctccaaatga agaaatagac      660

cgtcagaatg atgaccaaag gaaatcaaac cgtcacaaag aactttttgc tttgcatcca      720

tcaccagatg aggaagaacc aatagaacgg cttagtgttc ctgatatacc caaagaacat      780

tttggtcaaa gacttcttgt aaaatgctta tcactcaagt ttgaaattga aattgaaccc      840

atttttgcaa gtttggcttt atatgatgtc aaggaaaaga aaaagatttc agaaaacttt      900

tattttgacc ttaattctga gcagatgaaa gggttgttac gtccacatgt accacctgct      960

gccattacta ccctggcaag atcagcaatt ttttctatca cttatccttc ccaagatgtt     1020

tttcttgtaa taaagctaga aaaagtccta cagcaaggag acattggaga gtgtgcagaa     1080

ccatatatga ttttcaaaga agcagatgcc accaagaata aagaaaaact ggagaaactg     1140

aagagtcaag cagatcagtt ttgccaaaga cttgggaaat atcgcatgcc ttttgcttgg     1200

actgcaatcc atttaatgaa tattgttagc agtgctggga gtttggaaag agattctaca     1260

gaagtagaaa tcagtactgg agaacgaaaa gggtcttggt cagagaggag gaattctagt     1320

attgttggca gacgatcact tgaaaggaca acaagtggag atgatgcttg taacttgacg     1380

agctttcgac cagctactct cacagtgaca aattttttta agcaggaagg agaccgctta     1440

agtgatgaag atctctacaa attccttgct gatatgagaa ggccatcttc tgtcttacgg     1500

cgactaagac ctattacagc tcagctcaag atagacattt ctcccgcacc tgaaaatccc     1560

cattattgcc taactccgga gctgcttcaa gtgaagcttt accctgacag tagagttaga     1620

cctaccagag aaatcttaga gtttcccgca agggatgttt atgttccaaa cactacttac     1680

agaaatcttc tctacatata ccctcagagt cttaattttg ccaatcgtca aggttctgct     1740

agaaatataa cagtgaaagt ccagtttatg tatggagagg atccaagcaa tgccatgccg     1800

gtaatctttg gtaaatctag ctgttcagaa ttttcaaagg aagcctatac agccgtagta     1860

tatcataaca ggtctcctga ttttcatgaa gaaatcaagg ttaagcttcc tgctacttta     1920

actgaccatc atcacttgct ttttactttt tatcatgtta gttgtcaaca aaaacaaaat     1980

actcctcttg aaacaccagt tggatataca tggataccaa tgcttcagaa tggacggttg     2040

aagactggcc agttttgctt gccagtctca ttggaaaaac caccacaggc ttattctgta     2100

ctgtctcctg aggttcctct acctggcatg aaatgggtag ataatcacaa aggtgttttt     2160

aatgttgaag ttgttgctgt ttcgtctatc catacacaag atccttatct tgacaaattt     2220

tttgctctgg tcaatgctct ggatgaacac ctgttcccag tccgaattgg ggacatgcga     2280

atcatggaaa ataacttaga aaatgaattg aagagcagta tttcagcact gaattcatcc     2340

cagctggaac cagtggtccg atttcttcat cttctgctag ataaactgat acttttagtt     2400

attagacctc ctgtcattgc tggccaaata gttaacctag gtcaagcatc ttttgaagcc     2460

atggcatcaa ttataaatcg acttcacaaa aacttggaag gaaatcatga ccagcatggc     2520

agaaacagcc ttcttgcatc atatattcat tatgttttcc gcctaccaaa tacttaccct     2580

aattcatcat caccaggtcc tgggggtttg ggaggatcag tgcattatgc cacaatggct     2640

agatctgcgg tgagacctgc aagccttaat ttaaatcgtt ctcgaagcct tagtaatagc     2700

aatccagata tatctgggac tcccacgtca ccagatgatg aagttcgatc aatcatcggg     2760

agtaagggtt tagatcgctc caattcctgg gttaacactg gtggtccaaa agctgcccca     2820

tggggatcca accccagtcc aagtgcagaa tcaacacagg ctatggatcg aagttgtaat     2880

cgtatgtctt cgcacacaga gacgtcaagt ttcttacaaa cattaacggg acgcttacca     2940

actaaaaagc tttttcacga ggagctggct ttgcagtggg ttgtttgcag tggcagcgtt     3000

cgggaatcag ctttgcaaca agcctggttc ttttttgaat taatggtaaa gagcatggtg     3060

caccatttat actttaatga taaacttgag gctccaagga aaagtcgttt tccagaacgt     3120

ttcatggatg acattgcagc tcttgtcagc acgattgcta gtgatatagt ttcacgattt     3180

cagaaggaca cagaaatggt tgagagactc aatacaagcc ttgcattctt tctcaatgat     3240

ctgttgtctg ttatggacag aggatttgtt tttagcctta taaagtcctg ctataaacag     3300

gtgtcttcaa agctttactc attaccgaat cccagtgttc tggtgtcctt gaggctggat     3360

tttctacgaa tcatctgcag tcatgagcac tatgttacat taaacttacc ctgcagctta     3420

cttactccac ctgcatctcc atcaccttct gtttcttctg caacatctca gagttctgga     3480

ttttctacga atgtacaaga ccaaaagatt gcaaatatgt ttgaattatc cgtgcctttc     3540

cgccaacagc attatttggc aggacttgtg ttaacagagc tggctgtcat tttagaccct     3600

gatgctgaag gactgtttgg attgcataag aaagtcatca atatggtaca caatttactc     3660

tccagtcacg actcagaccc gcggtactct gaccctcaga taaaggctcg agtggccatg     3720

ttgtatctac ctctgattgg tattatcatg gaaactgtac ctcagctgta tgattttaca     3780

gaaactcaca atcaacgagg aagaccaatt tgtatagcca ctgatgatta tgaaagtgag     3840

agcggaagta tgataagcca gaccgttgcc atggcaatcg cagggacatc ggtccctcaa     3900

ctaacaaggc ctggcagttt cctcctcacg tcaacgagtg gcaggcaaca cactaccttt     3960

tcagcagaat caagtcgaag ccttttgatc tgtctacttt gggttctcaa aaatgcagat     4020

gaaacagttc tacagaagtg gtttacagat ctctcagtct tgcagctaaa ccggctatta     4080

gatctgcttt atctctgtgt gtcttgcttt gagtataaag ggaaaaaagt gtttgaacga     4140

atgaatagct tgacctttaa gaaatcaaaa gacatgagag caaagcttga agaagctatt     4200

cttgggagca taggtgccag gcaagaaatg gtacggcgaa gccgaggaca gctcgagaga     4260

agcccatctg gaagtgcctt tggaagtcaa gaaaatttga ggtggaggaa agatatgact     4320

cactggcgtc aaaacacaga gaagcttgac aaatcaagag cagagattga acacgaagca     4380

ctgattgatg gaaacctggc tacagaagca aacctaatca ttttagatac attagagatt     4440

gttgttcaga ccgtttctgt aacggaatcc aaagagagca ttcttggtgg agtgctaaaa     4500

gtgctactac acagcatggc ctgtaaccaa agtgcagttt atctacaaca ctgttttgct     4560

acacagagag ccttggtttc aaagtttcct gaactcttat ttgaagaaga gacagagcag     4620

tgtgctgatt tatgcctcag gcttctccga cactgtagca gtagcatcgg tacaatacgg     4680

tcacacgcca gtgcctccct ttacctacta atgaggcaaa actttgagat tgggaataac     4740

tttgccaggg ttaaaatgca ggtaacaatg tcactatcct ccttggtggg cacatctcag     4800

aattttaatg aagaattctt aagacgttct ctaaagacta tattgacata tgctgaagaa     4860

gatctggaat tgagggaaac aacatttcct gatcaggtcc aggatctggt tttcaatctc     4920

catatgattc tttctgatac tgtgaaaatg aaggaacacc aggaggatcc tgaaatgttg     4980

attgatctaa tgtacagaat tgccaagggt taccagacct ctccagatct gcgattgacc     5040

tggttgcaga acatggcagg caagcactca gaacgaagca atcatgctga agctgcacag     5100

tgtctagtcc actcagcagc acttgttgct gaatatttga gcatgctgga ggaccggaaa     5160

tatcttcctg tgggatgtgt aacatttcag aatatttcat ctaatgtttt agaagaatct     5220

gcggtctcag atgatgtggt atctccagat gaagaaggta tctgctctgg aaaatacttt     5280

actgagtcag gacttgtggg attactggaa caagcagctg cttccttctc tatggctggc     5340

atgtatgaag cagttaatga agtttacaaa gtacttattc ctattcatga agctaatcgg     5400

gatgcaaaga aactatccac aattcatggt aaacttcaag aagcattcag caaaattgtt     5460

catcaggatg gtaagcggat gtttggcacc tattttcgtg ttggttttta tggaaccaag     5520

ttcggggatt tggatgaaca agaatttgtt tacaaggagc ctgcaataac caaacttgca     5580

gagatatctc acagattgga gggattttac ggagaaagat ttggagagga tgtggttgaa     5640

gtaatcaaag actctaatcc tgtagacaag tgtaaattag atcctaacaa ggcatatatt     5700

cagattacct atgtggagcc atactttgac acatatgaga tgaaggacag aatcacctat     5760

ttcgacaaaa attacaatct tcgtcgattc atgtactgta caccctttac tttagatggc     5820

cgtgcccatg gggaacttca tgaacaattc aaaaggaaga ccattctgac tacgtctcat     5880

gcctttcctt atattaaaac aagggtcaat gtcactcata aagaagagat catcttaaca     5940

ccaattgaag ttgctattga ggacatgcag aaaaagacac aggagttggc atttgcaaca     6000

catcaggatc ccgcagaccc caaaatgctt cagatggtac tccagggatc tgtaggcacc     6060

acagtgaatc aggggccttt ggaagttgcc caggtttttc tgtctgaaat acctagtgac     6120

ccaaagctct tcagacatca taataaactg cgactctgct ttaaagattt tactaaaagg     6180

tgtgaagatg ccttaagaaa aaataagagc ttaattgggc cggatcaaaa ggagtatcaa     6240

agggaactgg agagaaacta tcatcgcctt aaagaggccc tacagccact gatcaacaga     6300

aagatccctc agttatacaa ggcagtattg cctgtcacct gccacagaga ttccttcagt     6360

cgaatgagcc ttcgcaaaat ggatctctaa                                      6390


<210>  76
<211>  2129
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Glu Arg Arg Ala Phe Ala Gln Lys Ile Ser Arg Thr Val Ala 
1               5                   10                  15      


Ala Glu Val Arg Lys Gln Ile Ser Gly Gln Tyr Ser Gly Ser Pro Gln 
            20                  25                  30          


Leu Leu Lys Asn Leu Asn Ile Val Gly Asn Ile Ser His His Thr Thr 
        35                  40                  45              


Val Pro Leu Thr Glu Ala Val Asp Pro Val Asp Leu Glu Asp Tyr Leu 
    50                  55                  60                  


Ile Thr His Pro Leu Ala Val Asp Ser Gly Pro Leu Arg Asp Leu Ile 
65                  70                  75                  80  


Glu Phe Pro Pro Asp Asp Ile Glu Val Val Tyr Ser Pro Arg Asp Cys 
                85                  90                  95      


Arg Thr Leu Val Ser Ala Val Pro Glu Glu Ser Glu Met Asp Pro His 
            100                 105                 110         


Val Arg Asp Cys Ile Arg Ser Tyr Thr Glu Asp Trp Ala Ile Val Ile 
        115                 120                 125             


Arg Lys Tyr His Lys Leu Gly Thr Gly Phe Asn Pro Asn Thr Leu Asp 
    130                 135                 140                 


Lys Gln Lys Glu Arg Gln Lys Gly Leu Pro Lys Gln Val Phe Glu Ser 
145                 150                 155                 160 


Asp Glu Ala Pro Asp Gly Asn Ser Tyr Gln Asp Asp Gln Asp Asp Leu 
                165                 170                 175     


Lys Arg Arg Ser Met Ser Ile Asp Asp Thr Pro Arg Gly Ser Trp Ala 
            180                 185                 190         


Cys Ser Ile Phe Asp Leu Lys Asn Ser Leu Pro Asp Ala Leu Leu Pro 
        195                 200                 205             


Asn Leu Leu Asp Arg Thr Pro Asn Glu Glu Ile Asp Arg Gln Asn Asp 
    210                 215                 220                 


Asp Gln Arg Lys Ser Asn Arg His Lys Glu Leu Phe Ala Leu His Pro 
225                 230                 235                 240 


Ser Pro Asp Glu Glu Glu Pro Ile Glu Arg Leu Ser Val Pro Asp Ile 
                245                 250                 255     


Pro Lys Glu His Phe Gly Gln Arg Leu Leu Val Lys Cys Leu Ser Leu 
            260                 265                 270         


Lys Phe Glu Ile Glu Ile Glu Pro Ile Phe Ala Ser Leu Ala Leu Tyr 
        275                 280                 285             


Asp Val Lys Glu Lys Lys Lys Ile Ser Glu Asn Phe Tyr Phe Asp Leu 
    290                 295                 300                 


Asn Ser Glu Gln Met Lys Gly Leu Leu Arg Pro His Val Pro Pro Ala 
305                 310                 315                 320 


Ala Ile Thr Thr Leu Ala Arg Ser Ala Ile Phe Ser Ile Thr Tyr Pro 
                325                 330                 335     


Ser Gln Asp Val Phe Leu Val Ile Lys Leu Glu Lys Val Leu Gln Gln 
            340                 345                 350         


Gly Asp Ile Gly Glu Cys Ala Glu Pro Tyr Met Ile Phe Lys Glu Ala 
        355                 360                 365             


Asp Ala Thr Lys Asn Lys Glu Lys Leu Glu Lys Leu Lys Ser Gln Ala 
    370                 375                 380                 


Asp Gln Phe Cys Gln Arg Leu Gly Lys Tyr Arg Met Pro Phe Ala Trp 
385                 390                 395                 400 


Thr Ala Ile His Leu Met Asn Ile Val Ser Ser Ala Gly Ser Leu Glu 
                405                 410                 415     


Arg Asp Ser Thr Glu Val Glu Ile Ser Thr Gly Glu Arg Lys Gly Ser 
            420                 425                 430         


Trp Ser Glu Arg Arg Asn Ser Ser Ile Val Gly Arg Arg Ser Leu Glu 
        435                 440                 445             


Arg Thr Thr Ser Gly Asp Asp Ala Cys Asn Leu Thr Ser Phe Arg Pro 
    450                 455                 460                 


Ala Thr Leu Thr Val Thr Asn Phe Phe Lys Gln Glu Gly Asp Arg Leu 
465                 470                 475                 480 


Ser Asp Glu Asp Leu Tyr Lys Phe Leu Ala Asp Met Arg Arg Pro Ser 
                485                 490                 495     


Ser Val Leu Arg Arg Leu Arg Pro Ile Thr Ala Gln Leu Lys Ile Asp 
            500                 505                 510         


Ile Ser Pro Ala Pro Glu Asn Pro His Tyr Cys Leu Thr Pro Glu Leu 
        515                 520                 525             


Leu Gln Val Lys Leu Tyr Pro Asp Ser Arg Val Arg Pro Thr Arg Glu 
    530                 535                 540                 


Ile Leu Glu Phe Pro Ala Arg Asp Val Tyr Val Pro Asn Thr Thr Tyr 
545                 550                 555                 560 


Arg Asn Leu Leu Tyr Ile Tyr Pro Gln Ser Leu Asn Phe Ala Asn Arg 
                565                 570                 575     


Gln Gly Ser Ala Arg Asn Ile Thr Val Lys Val Gln Phe Met Tyr Gly 
            580                 585                 590         


Glu Asp Pro Ser Asn Ala Met Pro Val Ile Phe Gly Lys Ser Ser Cys 
        595                 600                 605             


Ser Glu Phe Ser Lys Glu Ala Tyr Thr Ala Val Val Tyr His Asn Arg 
    610                 615                 620                 


Ser Pro Asp Phe His Glu Glu Ile Lys Val Lys Leu Pro Ala Thr Leu 
625                 630                 635                 640 


Thr Asp His His His Leu Leu Phe Thr Phe Tyr His Val Ser Cys Gln 
                645                 650                 655     


Gln Lys Gln Asn Thr Pro Leu Glu Thr Pro Val Gly Tyr Thr Trp Ile 
            660                 665                 670         


Pro Met Leu Gln Asn Gly Arg Leu Lys Thr Gly Gln Phe Cys Leu Pro 
        675                 680                 685             


Val Ser Leu Glu Lys Pro Pro Gln Ala Tyr Ser Val Leu Ser Pro Glu 
    690                 695                 700                 


Val Pro Leu Pro Gly Met Lys Trp Val Asp Asn His Lys Gly Val Phe 
705                 710                 715                 720 


Asn Val Glu Val Val Ala Val Ser Ser Ile His Thr Gln Asp Pro Tyr 
                725                 730                 735     


Leu Asp Lys Phe Phe Ala Leu Val Asn Ala Leu Asp Glu His Leu Phe 
            740                 745                 750         


Pro Val Arg Ile Gly Asp Met Arg Ile Met Glu Asn Asn Leu Glu Asn 
        755                 760                 765             


Glu Leu Lys Ser Ser Ile Ser Ala Leu Asn Ser Ser Gln Leu Glu Pro 
    770                 775                 780                 


Val Val Arg Phe Leu His Leu Leu Leu Asp Lys Leu Ile Leu Leu Val 
785                 790                 795                 800 


Ile Arg Pro Pro Val Ile Ala Gly Gln Ile Val Asn Leu Gly Gln Ala 
                805                 810                 815     


Ser Phe Glu Ala Met Ala Ser Ile Ile Asn Arg Leu His Lys Asn Leu 
            820                 825                 830         


Glu Gly Asn His Asp Gln His Gly Arg Asn Ser Leu Leu Ala Ser Tyr 
        835                 840                 845             


Ile His Tyr Val Phe Arg Leu Pro Asn Thr Tyr Pro Asn Ser Ser Ser 
    850                 855                 860                 


Pro Gly Pro Gly Gly Leu Gly Gly Ser Val His Tyr Ala Thr Met Ala 
865                 870                 875                 880 


Arg Ser Ala Val Arg Pro Ala Ser Leu Asn Leu Asn Arg Ser Arg Ser 
                885                 890                 895     


Leu Ser Asn Ser Asn Pro Asp Ile Ser Gly Thr Pro Thr Ser Pro Asp 
            900                 905                 910         


Asp Glu Val Arg Ser Ile Ile Gly Ser Lys Gly Leu Asp Arg Ser Asn 
        915                 920                 925             


Ser Trp Val Asn Thr Gly Gly Pro Lys Ala Ala Pro Trp Gly Ser Asn 
    930                 935                 940                 


Pro Ser Pro Ser Ala Glu Ser Thr Gln Ala Met Asp Arg Ser Cys Asn 
945                 950                 955                 960 


Arg Met Ser Ser His Thr Glu Thr Ser Ser Phe Leu Gln Thr Leu Thr 
                965                 970                 975     


Gly Arg Leu Pro Thr Lys Lys Leu Phe His Glu Glu Leu Ala Leu Gln 
            980                 985                 990         


Trp Val Val Cys Ser Gly Ser Val  Arg Glu Ser Ala Leu  Gln Gln Ala 
        995                 1000                 1005             


Trp Phe  Phe Phe Glu Leu Met  Val Lys Ser Met Val  His His Leu 
    1010                 1015                 1020             


Tyr Phe  Asn Asp Lys Leu Glu  Ala Pro Arg Lys Ser  Arg Phe Pro 
    1025                 1030                 1035             


Glu Arg  Phe Met Asp Asp Ile  Ala Ala Leu Val Ser  Thr Ile Ala 
    1040                 1045                 1050             


Ser Asp  Ile Val Ser Arg Phe  Gln Lys Asp Thr Glu  Met Val Glu 
    1055                 1060                 1065             


Arg Leu  Asn Thr Ser Leu Ala  Phe Phe Leu Asn Asp  Leu Leu Ser 
    1070                 1075                 1080             


Val Met  Asp Arg Gly Phe Val  Phe Ser Leu Ile Lys  Ser Cys Tyr 
    1085                 1090                 1095             


Lys Gln  Val Ser Ser Lys Leu  Tyr Ser Leu Pro Asn  Pro Ser Val 
    1100                 1105                 1110             


Leu Val  Ser Leu Arg Leu Asp  Phe Leu Arg Ile Ile  Cys Ser His 
    1115                 1120                 1125             


Glu His  Tyr Val Thr Leu Asn  Leu Pro Cys Ser Leu  Leu Thr Pro 
    1130                 1135                 1140             


Pro Ala  Ser Pro Ser Pro Ser  Val Ser Ser Ala Thr  Ser Gln Ser 
    1145                 1150                 1155             


Ser Gly  Phe Ser Thr Asn Val  Gln Asp Gln Lys Ile  Ala Asn Met 
    1160                 1165                 1170             


Phe Glu  Leu Ser Val Pro Phe  Arg Gln Gln His Tyr  Leu Ala Gly 
    1175                 1180                 1185             


Leu Val  Leu Thr Glu Leu Ala  Val Ile Leu Asp Pro  Asp Ala Glu 
    1190                 1195                 1200             


Gly Leu  Phe Gly Leu His Lys  Lys Val Ile Asn Met  Val His Asn 
    1205                 1210                 1215             


Leu Leu  Ser Ser His Asp Ser  Asp Pro Arg Tyr Ser  Asp Pro Gln 
    1220                 1225                 1230             


Ile Lys  Ala Arg Val Ala Met  Leu Tyr Leu Pro Leu  Ile Gly Ile 
    1235                 1240                 1245             


Ile Met  Glu Thr Val Pro Gln  Leu Tyr Asp Phe Thr  Glu Thr His 
    1250                 1255                 1260             


Asn Gln  Arg Gly Arg Pro Ile  Cys Ile Ala Thr Asp  Asp Tyr Glu 
    1265                 1270                 1275             


Ser Glu  Ser Gly Ser Met Ile  Ser Gln Thr Val Ala  Met Ala Ile 
    1280                 1285                 1290             


Ala Gly  Thr Ser Val Pro Gln  Leu Thr Arg Pro Gly  Ser Phe Leu 
    1295                 1300                 1305             


Leu Thr  Ser Thr Ser Gly Arg  Gln His Thr Thr Phe  Ser Ala Glu 
    1310                 1315                 1320             


Ser Ser  Arg Ser Leu Leu Ile  Cys Leu Leu Trp Val  Leu Lys Asn 
    1325                 1330                 1335             


Ala Asp  Glu Thr Val Leu Gln  Lys Trp Phe Thr Asp  Leu Ser Val 
    1340                 1345                 1350             


Leu Gln  Leu Asn Arg Leu Leu  Asp Leu Leu Tyr Leu  Cys Val Ser 
    1355                 1360                 1365             


Cys Phe  Glu Tyr Lys Gly Lys  Lys Val Phe Glu Arg  Met Asn Ser 
    1370                 1375                 1380             


Leu Thr  Phe Lys Lys Ser Lys  Asp Met Arg Ala Lys  Leu Glu Glu 
    1385                 1390                 1395             


Ala Ile  Leu Gly Ser Ile Gly  Ala Arg Gln Glu Met  Val Arg Arg 
    1400                 1405                 1410             


Ser Arg  Gly Gln Leu Glu Arg  Ser Pro Ser Gly Ser  Ala Phe Gly 
    1415                 1420                 1425             


Ser Gln  Glu Asn Leu Arg Trp  Arg Lys Asp Met Thr  His Trp Arg 
    1430                 1435                 1440             


Gln Asn  Thr Glu Lys Leu Asp  Lys Ser Arg Ala Glu  Ile Glu His 
    1445                 1450                 1455             


Glu Ala  Leu Ile Asp Gly Asn  Leu Ala Thr Glu Ala  Asn Leu Ile 
    1460                 1465                 1470             


Ile Leu  Asp Thr Leu Glu Ile  Val Val Gln Thr Val  Ser Val Thr 
    1475                 1480                 1485             


Glu Ser  Lys Glu Ser Ile Leu  Gly Gly Val Leu Lys  Val Leu Leu 
    1490                 1495                 1500             


His Ser  Met Ala Cys Asn Gln  Ser Ala Val Tyr Leu  Gln His Cys 
    1505                 1510                 1515             


Phe Ala  Thr Gln Arg Ala Leu  Val Ser Lys Phe Pro  Glu Leu Leu 
    1520                 1525                 1530             


Phe Glu  Glu Glu Thr Glu Gln  Cys Ala Asp Leu Cys  Leu Arg Leu 
    1535                 1540                 1545             


Leu Arg  His Cys Ser Ser Ser  Ile Gly Thr Ile Arg  Ser His Ala 
    1550                 1555                 1560             


Ser Ala  Ser Leu Tyr Leu Leu  Met Arg Gln Asn Phe  Glu Ile Gly 
    1565                 1570                 1575             


Asn Asn  Phe Ala Arg Val Lys  Met Gln Val Thr Met  Ser Leu Ser 
    1580                 1585                 1590             


Ser Leu  Val Gly Thr Ser Gln  Asn Phe Asn Glu Glu  Phe Leu Arg 
    1595                 1600                 1605             


Arg Ser  Leu Lys Thr Ile Leu  Thr Tyr Ala Glu Glu  Asp Leu Glu 
    1610                 1615                 1620             


Leu Arg  Glu Thr Thr Phe Pro  Asp Gln Val Gln Asp  Leu Val Phe 
    1625                 1630                 1635             


Asn Leu  His Met Ile Leu Ser  Asp Thr Val Lys Met  Lys Glu His 
    1640                 1645                 1650             


Gln Glu  Asp Pro Glu Met Leu  Ile Asp Leu Met Tyr  Arg Ile Ala 
    1655                 1660                 1665             


Lys Gly  Tyr Gln Thr Ser Pro  Asp Leu Arg Leu Thr  Trp Leu Gln 
    1670                 1675                 1680             


Asn Met  Ala Gly Lys His Ser  Glu Arg Ser Asn His  Ala Glu Ala 
    1685                 1690                 1695             


Ala Gln  Cys Leu Val His Ser  Ala Ala Leu Val Ala  Glu Tyr Leu 
    1700                 1705                 1710             


Ser Met  Leu Glu Asp Arg Lys  Tyr Leu Pro Val Gly  Cys Val Thr 
    1715                 1720                 1725             


Phe Gln  Asn Ile Ser Ser Asn  Val Leu Glu Glu Ser  Ala Val Ser 
    1730                 1735                 1740             


Asp Asp  Val Val Ser Pro Asp  Glu Glu Gly Ile Cys  Ser Gly Lys 
    1745                 1750                 1755             


Tyr Phe  Thr Glu Ser Gly Leu  Val Gly Leu Leu Glu  Gln Ala Ala 
    1760                 1765                 1770             


Ala Ser  Phe Ser Met Ala Gly  Met Tyr Glu Ala Val  Asn Glu Val 
    1775                 1780                 1785             


Tyr Lys  Val Leu Ile Pro Ile  His Glu Ala Asn Arg  Asp Ala Lys 
    1790                 1795                 1800             


Lys Leu  Ser Thr Ile His Gly  Lys Leu Gln Glu Ala  Phe Ser Lys 
    1805                 1810                 1815             


Ile Val  His Gln Asp Gly Lys  Arg Met Phe Gly Thr  Tyr Phe Arg 
    1820                 1825                 1830             


Val Gly  Phe Tyr Gly Thr Lys  Phe Gly Asp Leu Asp  Glu Gln Glu 
    1835                 1840                 1845             


Phe Val  Tyr Lys Glu Pro Ala  Ile Thr Lys Leu Ala  Glu Ile Ser 
    1850                 1855                 1860             


His Arg  Leu Glu Gly Phe Tyr  Gly Glu Arg Phe Gly  Glu Asp Val 
    1865                 1870                 1875             


Val Glu  Val Ile Lys Asp Ser  Asn Pro Val Asp Lys  Cys Lys Leu 
    1880                 1885                 1890             


Asp Pro  Asn Lys Ala Tyr Ile  Gln Ile Thr Tyr Val  Glu Pro Tyr 
    1895                 1900                 1905             


Phe Asp  Thr Tyr Glu Met Lys  Asp Arg Ile Thr Tyr  Phe Asp Lys 
    1910                 1915                 1920             


Asn Tyr  Asn Leu Arg Arg Phe  Met Tyr Cys Thr Pro  Phe Thr Leu 
    1925                 1930                 1935             


Asp Gly  Arg Ala His Gly Glu  Leu His Glu Gln Phe  Lys Arg Lys 
    1940                 1945                 1950             


Thr Ile  Leu Thr Thr Ser His  Ala Phe Pro Tyr Ile  Lys Thr Arg 
    1955                 1960                 1965             


Val Asn  Val Thr His Lys Glu  Glu Ile Ile Leu Thr  Pro Ile Glu 
    1970                 1975                 1980             


Val Ala  Ile Glu Asp Met Gln  Lys Lys Thr Gln Glu  Leu Ala Phe 
    1985                 1990                 1995             


Ala Thr  His Gln Asp Pro Ala  Asp Pro Lys Met Leu  Gln Met Val 
    2000                 2005                 2010             


Leu Gln  Gly Ser Val Gly Thr  Thr Val Asn Gln Gly  Pro Leu Glu 
    2015                 2020                 2025             


Val Ala  Gln Val Phe Leu Ser  Glu Ile Pro Ser Asp  Pro Lys Leu 
    2030                 2035                 2040             


Phe Arg  His His Asn Lys Leu  Arg Leu Cys Phe Lys  Asp Phe Thr 
    2045                 2050                 2055             


Lys Arg  Cys Glu Asp Ala Leu  Arg Lys Asn Lys Ser  Leu Ile Gly 
    2060                 2065                 2070             


Pro Asp  Gln Lys Glu Tyr Gln  Arg Glu Leu Glu Arg  Asn Tyr His 
    2075                 2080                 2085             


Arg Leu  Lys Glu Ala Leu Gln  Pro Leu Ile Asn Arg  Lys Ile Pro 
    2090                 2095                 2100             


Gln Leu  Tyr Lys Ala Val Leu  Pro Val Thr Cys His  Arg Asp Ser 
    2105                 2110                 2115             


Phe Ser  Arg Met Ser Leu Arg  Lys Met Asp Leu 
    2120                 2125                 


<210>  77
<211>  7884
<212>  DNA
<213>  Homo sapiens

<400>  77
atggaaaaac tccatgggca tgtgtctgcc catccagaca tcctctcctt ggagaaccgg       60

tgcctggcta tgctccctga cttacagccc ttggagaaac tacatcagca tgtatctacc      120

cactcagata tcctctcctt gaagaaccag tgcctagcca cgcttcctga cctgaagacc      180

atggaaaaac cacatggata tgtgtctgcc cacccagaca tcctctcctt ggagaaccag      240

tgcctggcca cactttctga cctgaagacc atggagaaac cacatggaca tgtttctgcc      300

cacccagaca tcctctcctt ggagaaccgg tgcctggcca ccctctctag tctaaagagc      360

actgtgtctg ccagcccctt gttccagagt ctacagatat ctcacatgac gcaagctgat      420

ttgtaccgtg tgaacaacag caattgcctg ctctctgagc ctccaagttg gagggctcag      480

catttctcta agggactaga cctttcaacc tgccctatag ccctgaaatc catctctgcc      540

acagagacag ctcaggaagc aactttgggt cgttggtttg attcagaaga gaagaaaggg      600

gcagagaccc aaatgccttc ttatagtctg agcttgggag aggaggagga ggtggaggat      660

ctggccgtga agctcacctc tggagactct gaatctcatc cagagcctac tgaccatgtc      720

cttcaggaaa agaagatggc tctactgagc ttgctgtgct ctactctggt ctcagaagta      780

aacatgaaca atacatctga ccccaccctg gctgccattt ttgaaatctg tcgtgaactt      840

gccctcctgg agcctgagtt tatcctcaag gcatctttgt atgccaggca gcagctgaac      900

gtccggaatg tggccaataa catcttggcc attgctgctt tcttgccggc gtgtcgcccc      960

cacctgcgac gatatttctg tgccattgtc cagctgcctt ctgactggat ccaggtggct     1020

gagctttacc agagcctggc tgagggagat aagaataagc tggtgcccct gcccgcctgt     1080

ctccgtactg ccatgacgga caaatttgcc cagtttgacg agtaccagct ggctaagtac     1140

aaccctcgga agcaccgggc caagagacac ccccgccggc caccccgctc tccagggatg     1200

gagcctccat tttctcacag atgttttcca aggtacatag ggtttctcag agaagagcag     1260

agaaagtttg agaaggccgg tgatacagtg tcagagaaaa agaatcctcc aaggttcacc     1320

ctgaagaagc tggttcagcg actgcacatc cacaagcctg cccagcacgt tcaagccctg     1380

ctgggttaca gatacccctc caacctacag ctcttttctc gaagtcgcct tcctgggcct     1440

tgggattcta gcagagctgg gaagaggatg aagctgtcta ggccagagac ctgggagcgg     1500

gagctgagcc tacgggggaa caaagcgtcg gtctgggagg aactcattga aaatgggaag     1560

cttcccttca tggccatgct tcggaacctg tgcaacctgc tgcgggttgg aatcagttcc     1620

cgccaccatg agctcattct ccagagactc cagcatgcga agtcggtgat ccacagtcgg     1680

cagtttccat tcagatttct taacgcccat gatgccattg atgccctcga ggctcaactc     1740

agaaatcaag cattgccctt tccttcgaat ataacactga tgaggcggat actaactaga     1800

aatgaaaaga accgtcccag gcggaggttt ctttgccacc taagccgtca gcagcttcgg     1860

atggcaatga ggatacctgt gttgtatgag cagctcaaga gggagaagct gagagtacac     1920

aaggccagac agtggaaata tgatggtgag atgctgaaca ggtaccgaca ggccctagag     1980

acagctgtga acctctctgt gaagcacagc ctgcccctgc tgccaggccg cactgtcttg     2040

gtctatctga cagatgctaa tgcagacagg ctctgtccaa agagcaaccc acaagggccc     2100

ccgctgaact atgcactgct gttgattggg atgatgatca cgagggcgga gcaggtggac     2160

gtcgtgctgt gtggaggtga cactctgaag actgcagtgc ttaaggcaga agaaggcatc     2220

ctgaagactg ccatcaagct ccaggctcaa gtccaggagt ttgatgaaaa tgatggatgg     2280

tccctgaata cttttgggaa atacctgctg tctctggctg gccaaagggt tcctgtggac     2340

agggtcatcc tccttggcca aagcatggat gatggaatga taaatgtggc caaacagctt     2400

tactggcagc gtgtgaattc caagtgcctc tttgttggta tcctcctaag aagggtacaa     2460

tacctgtcaa cagatttgaa tcccaatgat gtgacactct caggctgtac tgatgcgata     2520

ctgaagttca ttgcagagca tggggcctcc catcttctgg aacatgtggg ccaaatggac     2580

aaaatattca agattccacc acccccagga aagacagggg tccagtctct ccggccactg     2640

gaagaggaca ctccaagccc cttggctcct gtttcccagc aaggatggcg cagcatccgg     2700

cttttcattt catccacttt ccgagacatg catggggagc gggacctgct gctgaggtct     2760

gtgctgccag cactgcaggc ccgagcggcc cctcaccgta tcagccttca cggaatcgac     2820

ctccgctggg gcgtcactga ggaggagacc cgtaggaaca gacaactgga agtgtgcctt     2880

ggggaggtgg agaacgcaca gctgtttgtg gggattctgg gctcccgtta tggatacatt     2940

ccccccagct acaaccttcc tgaccatcca cacttccact gggcccagca gtacccttca     3000

gggcgctctg tgacagagat ggaggtgatg cagttcctga accggaacca acgtctgcag     3060

ccctctgccc aagctctcat ctacttccgg gattccagct tcctcagctc tgtgccagat     3120

gcctggaaat ctgactttgt ttctgagtct gaagaggccg cacgtcggat ctcagaactg     3180

aagagctacc taagcagaca gaaagggatc acctgccgca gatacccctg tgagtggggg     3240

ggtgtggcag ctggccggcc ctatgttggc gggctggagg agtttgggca gttggttctg     3300

caggatgtat ggaatatgat ccagaagctc tacctgcagc ctggggccct gctggagcag     3360

ccagtgtcca tcccagacga tgacttggtc caggccacct tccagcagct gcagaagcca     3420

ccgagtcctg cccggccacg ccttcttcag gacacagtgc aacggctgat gctgccccac     3480

ggaaggctga gcctggtgac ggggcagtca ggacagggca agacagcctt cctggcatct     3540

cttgtgtcag ccctgcaggc tcctgatggg gccaaggtgg catcattagt cttcttccac     3600

ttttctgggg ctcgtcctga ccagggtctt gccctcactc tgctcagacg cctctgtacc     3660

tatctgcgtg gccaactaaa agagccaggt gccctcccca gcacctaccg aagcctggtg     3720

tgggagctgc agcagaggct gctgcccaag tctgctgagt ccctgcatcc tggccagacc     3780

caggtcctga tcatcgatgg ggctgatagg ttagtggacc agaatgggca gctgatttca     3840

gactggatcc caaagaagct tccccggtgt gtacacctgg tgctgagtgt gtctagtgat     3900

gcaggcctag gggagaccct tgagcagagc cagggtgccc acgtgctggc cttggggcct     3960

ctggaggcct ctgctcgggc ccggctggtg agagaggagc tggccctgta cgggaagcgg     4020

ctggaggagt caccatttaa caaccagatg cgactgctgc tggtgaagcg ggaatcaggc     4080

cggccgctct acctgcgctt ggtcaccgat cacctgaggc tcttcacgct gtatgagcag     4140

gtgtctgaga gactccggac cctgcctgcc actgtccccc tgctgctgca gcacatcctg     4200

agcacactgg agaaggagca cgggcctgat gtccttcccc aggccttgac tgccctagaa     4260

gtcacacgga gtggtttgac tgtggaccag ctgcacggag tgctgagtgt gtggcggaca     4320

ctaccgaagg ggactaagag ctgggaagaa gcagtggctg ctggtaacag tggagacccc     4380

taccccatgg gcccgtttgc ctgcctcgtc cagagtctgc gcagtttgct aggggagggc     4440

cctctggagc gccctggtgc ccggctgtgc ctccctgatg ggcccctgag aacagcagct     4500

aaacgttgct atgggaagag gccagggcta gaggacacgg cacacatcct cattgcagct     4560

cagctctgga agacatgtga cgctgatgcc tcaggcacct tccgaagttg ccctcctgag     4620

gctctgggag acctgcctta ccacctgctc cagagcggga accgtggact tctttcgaag     4680

ttccttacca acctccatgt ggtggctgca cacttggaat tgggtctggt ctctcggctc     4740

ttggaggccc atgccctcta tgcttcttca gtccccaaag aggaacaaaa gctccccgag     4800

gctgacgttg cagtgtttcg caccttcctg aggcagcagg cttcaatcct cagccagtac     4860

ccccggctcc tgccccagca ggcagccaac cagcccctgg actcacctct ttgccaccaa     4920

gcctcgctgc tctcccggag atggcacctc caacacacac tacgatggct taataaaccc     4980

cggaccatga aaaatcagca aagctccagc ctgtctctgg cagtttcctc atcccctact     5040

gctgtggcct tctccaccaa tgggcaaaga gcagctgtgg gcactgccaa tgggacagtt     5100

tacctgttgg acctgagaac ttggcaggag gagaagtctg tggtgagtgg ctgtgatgga     5160

atctctgctt gtttgttcct ctccgatgat acactctttc ttactgcctt cgacgggctc     5220

ctggagctct gggacctgca gcatggttgt cgggtgctgc agactaaggc tcaccagtac     5280

caaatcactg gctgctgcct gagcccagac tgccggctgc tagccaccgt gtgcttggga     5340

ggatgcctaa agctgtggga cacagtccgt gggcagctgg ccttccagca cacctacccc     5400

aagtccctga actgtgttgc cttccaccca gaggggcagg taatagccac aggcagctgg     5460

gctggcagca tcagcttctt ccaggtggat gggctcaaag tcaccaagga cctgggggca     5520

cccggagcct ctatccgtac cttggccttc aatgtgcctg ggggggttgt ggctgtgggc     5580

cggctggaca gtatggtgga gctgtgggcc tggcgagaag gggcacggct ggctgccttc     5640

cctgcccacc atggctttgt tgctgctgcg cttttcctgc atgcgggttg ccagttactg     5700

acggctggag aggatggcaa ggttcaggtg tggtcagggt ctctgggtcg gccccgtggg     5760

cacctgggtt ccctttctct ctctcctgcc ctctctgtgg cactcagccc agatggtgat     5820

cgggtggctg ttggatatcg agcggatggc attaggatct acaaaatctc ttcaggttcc     5880

cagggggctc agggtcaggc actggatgtg gcagtgtccg ccctggcctg gctaagcccc     5940

aaggtattgg tgagtggtgc agaagatggg tccttgcagg gctgggcact caaggaatgc     6000

tcccttcagt ccctctggct cctgtccaga ttccagaagc ctgtgctagg actggccact     6060

tcccaggagc tcttggcttc tgcctcagag gatttcacag tgcagctgtg gccaaggcag     6120

ctgctgacgc ggccacacaa ggcagaagac tttccctgtg gcactgagct gcggggacat     6180

gagggccctg tgagctgctg tagtttcagc actgatggag gcagcctggc caccgggggc     6240

cgggatcgga gtctcctctg ctgggacgtg aggacaccca aaacccctgt tttgatccac     6300

tccttccctg cctgtcaccg tgactgggtc actggctgtg cctggaccaa agataaccta     6360

ctgatatcct gctccagtga tggctctgtg gggctctggg acccagagtc aggacagcgg     6420

cttggtcagt tcctgggtca tcagagtgct gtgagcgctg tggcagctgt ggaggagcac     6480

gtggtgtctg tgagccggga tgggaccttg aaagtgtggg accatcaagg cgtggagctg     6540

accagcatcc ctgctcactc aggacccatt agccactgtg cagctgccat ggagccccgt     6600

gcagctggac agcctgggtc agagcttctg gtggtaaccg tcgggctaga tggggccaca     6660

cggttatggc atccactctt ggtgtgccaa acccacaccc tcctgggaca cagcggccca     6720

gtccgtgctg ctgctgtttc agaaacctca ggcctcatgc tgaccgcctc tgaggatggt     6780

tctgtacggc tctggcaggt tcctaaggaa gcagatgaca catgtatacc aaggagttct     6840

gcagccgtca ctgctgtggc ttgggcacca gatggttcca tggcagtatc tggaaatcaa     6900

gctggggaac taatcttgtg gcaggaagct aaggctgtgg ccacagcaca ggctccaggc     6960

cacattggtg ctctgatctg gtcctcggca cacacctttt ttgtcctcag tgctgatgag     7020

aaaatcagcg agtggcaagt gaaactgcgg aagggttcgg cacccggaaa tttgagtctt     7080

cacctgaacc gaattctaca ggaggactta ggggtgctga caagtctgga ttgggctcct     7140

gatggtcact ttctcatctt ggccaaagca gatttgaagt tactttgcat gaagccaggg     7200

gatgctccat ctgaaatctg gagcagctat acagaaaatc ctatgatatt gtccacccac     7260

aaggagtatg gcatatttgt cctgcagccc aaggatcctg gagttctttc tttcttgagg     7320

caaaaggaat caggagagtt tgaagagagg ctgaactttg atataaactt agagaatcct     7380

agtaggaccc taatatcgat aactcaagcc aaacctgaat ctgagtcctc atttttgtgt     7440

gccagctctg atgggatcct atggaacctg gccaaatgca gcccagaagg agaatggacc     7500

acaggtaaca tgtggcagaa aaaagcaaac actccagaaa cccaaactcc agggacagac     7560

ccatctacct gcagggaatc tgatgccagc atggatagtg atgccagcat ggatagtgag     7620

ccaacaccac atctaaagac acggcagcgt agaaagattc actcgggctc tgtcacagcc     7680

ctccatgtgc tacctgagtt gctggtgaca gcttcgaagg acagagatgt taagctatgg     7740

gagagaccca gtatgcagct gctgggcctg ttccgatgcg aagggtcagt gagctgcctg     7800

gaaccttggc tgggcgctaa ctccaccctg cagcttgccg tgggagacgt gcagggcaat     7860

gtgtactttc tgaattggga atga                                            7884


<210>  78
<211>  2627
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Lys Leu His Gly His Val Ser Ala His Pro Asp Ile Leu Ser 
1               5                   10                  15      


Leu Glu Asn Arg Cys Leu Ala Met Leu Pro Asp Leu Gln Pro Leu Glu 
            20                  25                  30          


Lys Leu His Gln His Val Ser Thr His Ser Asp Ile Leu Ser Leu Lys 
        35                  40                  45              


Asn Gln Cys Leu Ala Thr Leu Pro Asp Leu Lys Thr Met Glu Lys Pro 
    50                  55                  60                  


His Gly Tyr Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Gln 
65                  70                  75                  80  


Cys Leu Ala Thr Leu Ser Asp Leu Lys Thr Met Glu Lys Pro His Gly 
                85                  90                  95      


His Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Arg Cys Leu 
            100                 105                 110         


Ala Thr Leu Ser Ser Leu Lys Ser Thr Val Ser Ala Ser Pro Leu Phe 
        115                 120                 125             


Gln Ser Leu Gln Ile Ser His Met Thr Gln Ala Asp Leu Tyr Arg Val 
    130                 135                 140                 


Asn Asn Ser Asn Cys Leu Leu Ser Glu Pro Pro Ser Trp Arg Ala Gln 
145                 150                 155                 160 


His Phe Ser Lys Gly Leu Asp Leu Ser Thr Cys Pro Ile Ala Leu Lys 
                165                 170                 175     


Ser Ile Ser Ala Thr Glu Thr Ala Gln Glu Ala Thr Leu Gly Arg Trp 
            180                 185                 190         


Phe Asp Ser Glu Glu Lys Lys Gly Ala Glu Thr Gln Met Pro Ser Tyr 
        195                 200                 205             


Ser Leu Ser Leu Gly Glu Glu Glu Glu Val Glu Asp Leu Ala Val Lys 
    210                 215                 220                 


Leu Thr Ser Gly Asp Ser Glu Ser His Pro Glu Pro Thr Asp His Val 
225                 230                 235                 240 


Leu Gln Glu Lys Lys Met Ala Leu Leu Ser Leu Leu Cys Ser Thr Leu 
                245                 250                 255     


Val Ser Glu Val Asn Met Asn Asn Thr Ser Asp Pro Thr Leu Ala Ala 
            260                 265                 270         


Ile Phe Glu Ile Cys Arg Glu Leu Ala Leu Leu Glu Pro Glu Phe Ile 
        275                 280                 285             


Leu Lys Ala Ser Leu Tyr Ala Arg Gln Gln Leu Asn Val Arg Asn Val 
    290                 295                 300                 


Ala Asn Asn Ile Leu Ala Ile Ala Ala Phe Leu Pro Ala Cys Arg Pro 
305                 310                 315                 320 


His Leu Arg Arg Tyr Phe Cys Ala Ile Val Gln Leu Pro Ser Asp Trp 
                325                 330                 335     


Ile Gln Val Ala Glu Leu Tyr Gln Ser Leu Ala Glu Gly Asp Lys Asn 
            340                 345                 350         


Lys Leu Val Pro Leu Pro Ala Cys Leu Arg Thr Ala Met Thr Asp Lys 
        355                 360                 365             


Phe Ala Gln Phe Asp Glu Tyr Gln Leu Ala Lys Tyr Asn Pro Arg Lys 
    370                 375                 380                 


His Arg Ala Lys Arg His Pro Arg Arg Pro Pro Arg Ser Pro Gly Met 
385                 390                 395                 400 


Glu Pro Pro Phe Ser His Arg Cys Phe Pro Arg Tyr Ile Gly Phe Leu 
                405                 410                 415     


Arg Glu Glu Gln Arg Lys Phe Glu Lys Ala Gly Asp Thr Val Ser Glu 
            420                 425                 430         


Lys Lys Asn Pro Pro Arg Phe Thr Leu Lys Lys Leu Val Gln Arg Leu 
        435                 440                 445             


His Ile His Lys Pro Ala Gln His Val Gln Ala Leu Leu Gly Tyr Arg 
    450                 455                 460                 


Tyr Pro Ser Asn Leu Gln Leu Phe Ser Arg Ser Arg Leu Pro Gly Pro 
465                 470                 475                 480 


Trp Asp Ser Ser Arg Ala Gly Lys Arg Met Lys Leu Ser Arg Pro Glu 
                485                 490                 495     


Thr Trp Glu Arg Glu Leu Ser Leu Arg Gly Asn Lys Ala Ser Val Trp 
            500                 505                 510         


Glu Glu Leu Ile Glu Asn Gly Lys Leu Pro Phe Met Ala Met Leu Arg 
        515                 520                 525             


Asn Leu Cys Asn Leu Leu Arg Val Gly Ile Ser Ser Arg His His Glu 
    530                 535                 540                 


Leu Ile Leu Gln Arg Leu Gln His Ala Lys Ser Val Ile His Ser Arg 
545                 550                 555                 560 


Gln Phe Pro Phe Arg Phe Leu Asn Ala His Asp Ala Ile Asp Ala Leu 
                565                 570                 575     


Glu Ala Gln Leu Arg Asn Gln Ala Leu Pro Phe Pro Ser Asn Ile Thr 
            580                 585                 590         


Leu Met Arg Arg Ile Leu Thr Arg Asn Glu Lys Asn Arg Pro Arg Arg 
        595                 600                 605             


Arg Phe Leu Cys His Leu Ser Arg Gln Gln Leu Arg Met Ala Met Arg 
    610                 615                 620                 


Ile Pro Val Leu Tyr Glu Gln Leu Lys Arg Glu Lys Leu Arg Val His 
625                 630                 635                 640 


Lys Ala Arg Gln Trp Lys Tyr Asp Gly Glu Met Leu Asn Arg Tyr Arg 
                645                 650                 655     


Gln Ala Leu Glu Thr Ala Val Asn Leu Ser Val Lys His Ser Leu Pro 
            660                 665                 670         


Leu Leu Pro Gly Arg Thr Val Leu Val Tyr Leu Thr Asp Ala Asn Ala 
        675                 680                 685             


Asp Arg Leu Cys Pro Lys Ser Asn Pro Gln Gly Pro Pro Leu Asn Tyr 
    690                 695                 700                 


Ala Leu Leu Leu Ile Gly Met Met Ile Thr Arg Ala Glu Gln Val Asp 
705                 710                 715                 720 


Val Val Leu Cys Gly Gly Asp Thr Leu Lys Thr Ala Val Leu Lys Ala 
                725                 730                 735     


Glu Glu Gly Ile Leu Lys Thr Ala Ile Lys Leu Gln Ala Gln Val Gln 
            740                 745                 750         


Glu Phe Asp Glu Asn Asp Gly Trp Ser Leu Asn Thr Phe Gly Lys Tyr 
        755                 760                 765             


Leu Leu Ser Leu Ala Gly Gln Arg Val Pro Val Asp Arg Val Ile Leu 
    770                 775                 780                 


Leu Gly Gln Ser Met Asp Asp Gly Met Ile Asn Val Ala Lys Gln Leu 
785                 790                 795                 800 


Tyr Trp Gln Arg Val Asn Ser Lys Cys Leu Phe Val Gly Ile Leu Leu 
                805                 810                 815     


Arg Arg Val Gln Tyr Leu Ser Thr Asp Leu Asn Pro Asn Asp Val Thr 
            820                 825                 830         


Leu Ser Gly Cys Thr Asp Ala Ile Leu Lys Phe Ile Ala Glu His Gly 
        835                 840                 845             


Ala Ser His Leu Leu Glu His Val Gly Gln Met Asp Lys Ile Phe Lys 
    850                 855                 860                 


Ile Pro Pro Pro Pro Gly Lys Thr Gly Val Gln Ser Leu Arg Pro Leu 
865                 870                 875                 880 


Glu Glu Asp Thr Pro Ser Pro Leu Ala Pro Val Ser Gln Gln Gly Trp 
                885                 890                 895     


Arg Ser Ile Arg Leu Phe Ile Ser Ser Thr Phe Arg Asp Met His Gly 
            900                 905                 910         


Glu Arg Asp Leu Leu Leu Arg Ser Val Leu Pro Ala Leu Gln Ala Arg 
        915                 920                 925             


Ala Ala Pro His Arg Ile Ser Leu His Gly Ile Asp Leu Arg Trp Gly 
    930                 935                 940                 


Val Thr Glu Glu Glu Thr Arg Arg Asn Arg Gln Leu Glu Val Cys Leu 
945                 950                 955                 960 


Gly Glu Val Glu Asn Ala Gln Leu Phe Val Gly Ile Leu Gly Ser Arg 
                965                 970                 975     


Tyr Gly Tyr Ile Pro Pro Ser Tyr Asn Leu Pro Asp His Pro His Phe 
            980                 985                 990         


His Trp Ala Gln Gln Tyr Pro Ser  Gly Arg Ser Val Thr  Glu Met Glu 
        995                 1000                 1005             


Val Met  Gln Phe Leu Asn Arg  Asn Gln Arg Leu Gln  Pro Ser Ala 
    1010                 1015                 1020             


Gln Ala  Leu Ile Tyr Phe Arg  Asp Ser Ser Phe Leu  Ser Ser Val 
    1025                 1030                 1035             


Pro Asp  Ala Trp Lys Ser Asp  Phe Val Ser Glu Ser  Glu Glu Ala 
    1040                 1045                 1050             


Ala Arg  Arg Ile Ser Glu Leu  Lys Ser Tyr Leu Ser  Arg Gln Lys 
    1055                 1060                 1065             


Gly Ile  Thr Cys Arg Arg Tyr  Pro Cys Glu Trp Gly  Gly Val Ala 
    1070                 1075                 1080             


Ala Gly  Arg Pro Tyr Val Gly  Gly Leu Glu Glu Phe  Gly Gln Leu 
    1085                 1090                 1095             


Val Leu  Gln Asp Val Trp Asn  Met Ile Gln Lys Leu  Tyr Leu Gln 
    1100                 1105                 1110             


Pro Gly  Ala Leu Leu Glu Gln  Pro Val Ser Ile Pro  Asp Asp Asp 
    1115                 1120                 1125             


Leu Val  Gln Ala Thr Phe Gln  Gln Leu Gln Lys Pro  Pro Ser Pro 
    1130                 1135                 1140             


Ala Arg  Pro Arg Leu Leu Gln  Asp Thr Val Gln Arg  Leu Met Leu 
    1145                 1150                 1155             


Pro His  Gly Arg Leu Ser Leu  Val Thr Gly Gln Ser  Gly Gln Gly 
    1160                 1165                 1170             


Lys Thr  Ala Phe Leu Ala Ser  Leu Val Ser Ala Leu  Gln Ala Pro 
    1175                 1180                 1185             


Asp Gly  Ala Lys Val Ala Ser  Leu Val Phe Phe His  Phe Ser Gly 
    1190                 1195                 1200             


Ala Arg  Pro Asp Gln Gly Leu  Ala Leu Thr Leu Leu  Arg Arg Leu 
    1205                 1210                 1215             


Cys Thr  Tyr Leu Arg Gly Gln  Leu Lys Glu Pro Gly  Ala Leu Pro 
    1220                 1225                 1230             


Ser Thr  Tyr Arg Ser Leu Val  Trp Glu Leu Gln Gln  Arg Leu Leu 
    1235                 1240                 1245             


Pro Lys  Ser Ala Glu Ser Leu  His Pro Gly Gln Thr  Gln Val Leu 
    1250                 1255                 1260             


Ile Ile  Asp Gly Ala Asp Arg  Leu Val Asp Gln Asn  Gly Gln Leu 
    1265                 1270                 1275             


Ile Ser  Asp Trp Ile Pro Lys  Lys Leu Pro Arg Cys  Val His Leu 
    1280                 1285                 1290             


Val Leu  Ser Val Ser Ser Asp  Ala Gly Leu Gly Glu  Thr Leu Glu 
    1295                 1300                 1305             


Gln Ser  Gln Gly Ala His Val  Leu Ala Leu Gly Pro  Leu Glu Ala 
    1310                 1315                 1320             


Ser Ala  Arg Ala Arg Leu Val  Arg Glu Glu Leu Ala  Leu Tyr Gly 
    1325                 1330                 1335             


Lys Arg  Leu Glu Glu Ser Pro  Phe Asn Asn Gln Met  Arg Leu Leu 
    1340                 1345                 1350             


Leu Val  Lys Arg Glu Ser Gly  Arg Pro Leu Tyr Leu  Arg Leu Val 
    1355                 1360                 1365             


Thr Asp  His Leu Arg Leu Phe  Thr Leu Tyr Glu Gln  Val Ser Glu 
    1370                 1375                 1380             


Arg Leu  Arg Thr Leu Pro Ala  Thr Val Pro Leu Leu  Leu Gln His 
    1385                 1390                 1395             


Ile Leu  Ser Thr Leu Glu Lys  Glu His Gly Pro Asp  Val Leu Pro 
    1400                 1405                 1410             


Gln Ala  Leu Thr Ala Leu Glu  Val Thr Arg Ser Gly  Leu Thr Val 
    1415                 1420                 1425             


Asp Gln  Leu His Gly Val Leu  Ser Val Trp Arg Thr  Leu Pro Lys 
    1430                 1435                 1440             


Gly Thr  Lys Ser Trp Glu Glu  Ala Val Ala Ala Gly  Asn Ser Gly 
    1445                 1450                 1455             


Asp Pro  Tyr Pro Met Gly Pro  Phe Ala Cys Leu Val  Gln Ser Leu 
    1460                 1465                 1470             


Arg Ser  Leu Leu Gly Glu Gly  Pro Leu Glu Arg Pro  Gly Ala Arg 
    1475                 1480                 1485             


Leu Cys  Leu Pro Asp Gly Pro  Leu Arg Thr Ala Ala  Lys Arg Cys 
    1490                 1495                 1500             


Tyr Gly  Lys Arg Pro Gly Leu  Glu Asp Thr Ala His  Ile Leu Ile 
    1505                 1510                 1515             


Ala Ala  Gln Leu Trp Lys Thr  Cys Asp Ala Asp Ala  Ser Gly Thr 
    1520                 1525                 1530             


Phe Arg  Ser Cys Pro Pro Glu  Ala Leu Gly Asp Leu  Pro Tyr His 
    1535                 1540                 1545             


Leu Leu  Gln Ser Gly Asn Arg  Gly Leu Leu Ser Lys  Phe Leu Thr 
    1550                 1555                 1560             


Asn Leu  His Val Val Ala Ala  His Leu Glu Leu Gly  Leu Val Ser 
    1565                 1570                 1575             


Arg Leu  Leu Glu Ala His Ala  Leu Tyr Ala Ser Ser  Val Pro Lys 
    1580                 1585                 1590             


Glu Glu  Gln Lys Leu Pro Glu  Ala Asp Val Ala Val  Phe Arg Thr 
    1595                 1600                 1605             


Phe Leu  Arg Gln Gln Ala Ser  Ile Leu Ser Gln Tyr  Pro Arg Leu 
    1610                 1615                 1620             


Leu Pro  Gln Gln Ala Ala Asn  Gln Pro Leu Asp Ser  Pro Leu Cys 
    1625                 1630                 1635             


His Gln  Ala Ser Leu Leu Ser  Arg Arg Trp His Leu  Gln His Thr 
    1640                 1645                 1650             


Leu Arg  Trp Leu Asn Lys Pro  Arg Thr Met Lys Asn  Gln Gln Ser 
    1655                 1660                 1665             


Ser Ser  Leu Ser Leu Ala Val  Ser Ser Ser Pro Thr  Ala Val Ala 
    1670                 1675                 1680             


Phe Ser  Thr Asn Gly Gln Arg  Ala Ala Val Gly Thr  Ala Asn Gly 
    1685                 1690                 1695             


Thr Val  Tyr Leu Leu Asp Leu  Arg Thr Trp Gln Glu  Glu Lys Ser 
    1700                 1705                 1710             


Val Val  Ser Gly Cys Asp Gly  Ile Ser Ala Cys Leu  Phe Leu Ser 
    1715                 1720                 1725             


Asp Asp  Thr Leu Phe Leu Thr  Ala Phe Asp Gly Leu  Leu Glu Leu 
    1730                 1735                 1740             


Trp Asp  Leu Gln His Gly Cys  Arg Val Leu Gln Thr  Lys Ala His 
    1745                 1750                 1755             


Gln Tyr  Gln Ile Thr Gly Cys  Cys Leu Ser Pro Asp  Cys Arg Leu 
    1760                 1765                 1770             


Leu Ala  Thr Val Cys Leu Gly  Gly Cys Leu Lys Leu  Trp Asp Thr 
    1775                 1780                 1785             


Val Arg  Gly Gln Leu Ala Phe  Gln His Thr Tyr Pro  Lys Ser Leu 
    1790                 1795                 1800             


Asn Cys  Val Ala Phe His Pro  Glu Gly Gln Val Ile  Ala Thr Gly 
    1805                 1810                 1815             


Ser Trp  Ala Gly Ser Ile Ser  Phe Phe Gln Val Asp  Gly Leu Lys 
    1820                 1825                 1830             


Val Thr  Lys Asp Leu Gly Ala  Pro Gly Ala Ser Ile  Arg Thr Leu 
    1835                 1840                 1845             


Ala Phe  Asn Val Pro Gly Gly  Val Val Ala Val Gly  Arg Leu Asp 
    1850                 1855                 1860             


Ser Met  Val Glu Leu Trp Ala  Trp Arg Glu Gly Ala  Arg Leu Ala 
    1865                 1870                 1875             


Ala Phe  Pro Ala His His Gly  Phe Val Ala Ala Ala  Leu Phe Leu 
    1880                 1885                 1890             


His Ala  Gly Cys Gln Leu Leu  Thr Ala Gly Glu Asp  Gly Lys Val 
    1895                 1900                 1905             


Gln Val  Trp Ser Gly Ser Leu  Gly Arg Pro Arg Gly  His Leu Gly 
    1910                 1915                 1920             


Ser Leu  Ser Leu Ser Pro Ala  Leu Ser Val Ala Leu  Ser Pro Asp 
    1925                 1930                 1935             


Gly Asp  Arg Val Ala Val Gly  Tyr Arg Ala Asp Gly  Ile Arg Ile 
    1940                 1945                 1950             


Tyr Lys  Ile Ser Ser Gly Ser  Gln Gly Ala Gln Gly  Gln Ala Leu 
    1955                 1960                 1965             


Asp Val  Ala Val Ser Ala Leu  Ala Trp Leu Ser Pro  Lys Val Leu 
    1970                 1975                 1980             


Val Ser  Gly Ala Glu Asp Gly  Ser Leu Gln Gly Trp  Ala Leu Lys 
    1985                 1990                 1995             


Glu Cys  Ser Leu Gln Ser Leu  Trp Leu Leu Ser Arg  Phe Gln Lys 
    2000                 2005                 2010             


Pro Val  Leu Gly Leu Ala Thr  Ser Gln Glu Leu Leu  Ala Ser Ala 
    2015                 2020                 2025             


Ser Glu  Asp Phe Thr Val Gln  Leu Trp Pro Arg Gln  Leu Leu Thr 
    2030                 2035                 2040             


Arg Pro  His Lys Ala Glu Asp  Phe Pro Cys Gly Thr  Glu Leu Arg 
    2045                 2050                 2055             


Gly His  Glu Gly Pro Val Ser  Cys Cys Ser Phe Ser  Thr Asp Gly 
    2060                 2065                 2070             


Gly Ser  Leu Ala Thr Gly Gly  Arg Asp Arg Ser Leu  Leu Cys Trp 
    2075                 2080                 2085             


Asp Val  Arg Thr Pro Lys Thr  Pro Val Leu Ile His  Ser Phe Pro 
    2090                 2095                 2100             


Ala Cys  His Arg Asp Trp Val  Thr Gly Cys Ala Trp  Thr Lys Asp 
    2105                 2110                 2115             


Asn Leu  Leu Ile Ser Cys Ser  Ser Asp Gly Ser Val  Gly Leu Trp 
    2120                 2125                 2130             


Asp Pro  Glu Ser Gly Gln Arg  Leu Gly Gln Phe Leu  Gly His Gln 
    2135                 2140                 2145             


Ser Ala  Val Ser Ala Val Ala  Ala Val Glu Glu His  Val Val Ser 
    2150                 2155                 2160             


Val Ser  Arg Asp Gly Thr Leu  Lys Val Trp Asp His  Gln Gly Val 
    2165                 2170                 2175             


Glu Leu  Thr Ser Ile Pro Ala  His Ser Gly Pro Ile  Ser His Cys 
    2180                 2185                 2190             


Ala Ala  Ala Met Glu Pro Arg  Ala Ala Gly Gln Pro  Gly Ser Glu 
    2195                 2200                 2205             


Leu Leu  Val Val Thr Val Gly  Leu Asp Gly Ala Thr  Arg Leu Trp 
    2210                 2215                 2220             


His Pro  Leu Leu Val Cys Gln  Thr His Thr Leu Leu  Gly His Ser 
    2225                 2230                 2235             


Gly Pro  Val Arg Ala Ala Ala  Val Ser Glu Thr Ser  Gly Leu Met 
    2240                 2245                 2250             


Leu Thr  Ala Ser Glu Asp Gly  Ser Val Arg Leu Trp  Gln Val Pro 
    2255                 2260                 2265             


Lys Glu  Ala Asp Asp Thr Cys  Ile Pro Arg Ser Ser  Ala Ala Val 
    2270                 2275                 2280             


Thr Ala  Val Ala Trp Ala Pro  Asp Gly Ser Met Ala  Val Ser Gly 
    2285                 2290                 2295             


Asn Gln  Ala Gly Glu Leu Ile  Leu Trp Gln Glu Ala  Lys Ala Val 
    2300                 2305                 2310             


Ala Thr  Ala Gln Ala Pro Gly  His Ile Gly Ala Leu  Ile Trp Ser 
    2315                 2320                 2325             


Ser Ala  His Thr Phe Phe Val  Leu Ser Ala Asp Glu  Lys Ile Ser 
    2330                 2335                 2340             


Glu Trp  Gln Val Lys Leu Arg  Lys Gly Ser Ala Pro  Gly Asn Leu 
    2345                 2350                 2355             


Ser Leu  His Leu Asn Arg Ile  Leu Gln Glu Asp Leu  Gly Val Leu 
    2360                 2365                 2370             


Thr Ser  Leu Asp Trp Ala Pro  Asp Gly His Phe Leu  Ile Leu Ala 
    2375                 2380                 2385             


Lys Ala  Asp Leu Lys Leu Leu  Cys Met Lys Pro Gly  Asp Ala Pro 
    2390                 2395                 2400             


Ser Glu  Ile Trp Ser Ser Tyr  Thr Glu Asn Pro Met  Ile Leu Ser 
    2405                 2410                 2415             


Thr His  Lys Glu Tyr Gly Ile  Phe Val Leu Gln Pro  Lys Asp Pro 
    2420                 2425                 2430             


Gly Val  Leu Ser Phe Leu Arg  Gln Lys Glu Ser Gly  Glu Phe Glu 
    2435                 2440                 2445             


Glu Arg  Leu Asn Phe Asp Ile  Asn Leu Glu Asn Pro  Ser Arg Thr 
    2450                 2455                 2460             


Leu Ile  Ser Ile Thr Gln Ala  Lys Pro Glu Ser Glu  Ser Ser Phe 
    2465                 2470                 2475             


Leu Cys  Ala Ser Ser Asp Gly  Ile Leu Trp Asn Leu  Ala Lys Cys 
    2480                 2485                 2490             


Ser Pro  Glu Gly Glu Trp Thr  Thr Gly Asn Met Trp  Gln Lys Lys 
    2495                 2500                 2505             


Ala Asn  Thr Pro Glu Thr Gln  Thr Pro Gly Thr Asp  Pro Ser Thr 
    2510                 2515                 2520             


Cys Arg  Glu Ser Asp Ala Ser  Met Asp Ser Asp Ala  Ser Met Asp 
    2525                 2530                 2535             


Ser Glu  Pro Thr Pro His Leu  Lys Thr Arg Gln Arg  Arg Lys Ile 
    2540                 2545                 2550             


His Ser  Gly Ser Val Thr Ala  Leu His Val Leu Pro  Glu Leu Leu 
    2555                 2560                 2565             


Val Thr  Ala Ser Lys Asp Arg  Asp Val Lys Leu Trp  Glu Arg Pro 
    2570                 2575                 2580             


Ser Met  Gln Leu Leu Gly Leu  Phe Arg Cys Glu Gly  Ser Val Ser 
    2585                 2590                 2595             


Cys Leu  Glu Pro Trp Leu Gly  Ala Asn Ser Thr Leu  Gln Leu Ala 
    2600                 2605                 2610             


Val Gly  Asp Val Gln Gly Asn  Val Tyr Phe Leu Asn  Trp Glu 
    2615                 2620                 2625         


<210>  79
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  79
atggaaaaag aaaaaggaaa tgatgatgga ataccagacc aagagaattc cttggatttt       60

tctgaacact ttaaccaact tgaattgttg gaaacacatg gacaccttat tcctactggt      120

actcaaagtc tttgggtagg caattctgat gaagatgagg agcaagatga caaaaatgaa      180

gagtggtatc gattgcaaga aaaaaaaatg gaaaaagacc caagcagatt gcttctttgg      240

gctgctgaaa aaaatcggct taccacagtg cggagactcc tttctgaaaa ggccactcac      300

gtgaacacta gggatgaaga tgagtatacc cctcttcatc gagcagccta cagtggacac      360

ttagatattg ttcaggagct cattgcacag ggggccgatg ttcatgcagt gactgtggat      420

ggctggacgc ccctgcacag tgcttgtaag tggaataata ccagagtggc ttctttctta      480

ctgcagcatg atgcagatat caatgcccaa acaaaaggcc tcttgacccc cttgcatctt      540

gctgctggga acagagacag caaggatacc ctagaactcc tcctgatgaa ccgttacgtc      600

aaaccagggc tgaaaaacaa cttggaagaa actgcatttg atattgccag gaggacaagt      660

atctatcact acctctttga aattgtggaa ggctgtacaa attcttcacc tcagtcttaa      720


<210>  80
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Lys Glu Lys Gly Asn Asp Asp Gly Ile Pro Asp Gln Glu Asn 
1               5                   10                  15      


Ser Leu Asp Phe Ser Glu His Phe Asn Gln Leu Glu Leu Leu Glu Thr 
            20                  25                  30          


His Gly His Leu Ile Pro Thr Gly Thr Gln Ser Leu Trp Val Gly Asn 
        35                  40                  45              


Ser Asp Glu Asp Glu Glu Gln Asp Asp Lys Asn Glu Glu Trp Tyr Arg 
    50                  55                  60                  


Leu Gln Glu Lys Lys Met Glu Lys Asp Pro Ser Arg Leu Leu Leu Trp 
65                  70                  75                  80  


Ala Ala Glu Lys Asn Arg Leu Thr Thr Val Arg Arg Leu Leu Ser Glu 
                85                  90                  95      


Lys Ala Thr His Val Asn Thr Arg Asp Glu Asp Glu Tyr Thr Pro Leu 
            100                 105                 110         


His Arg Ala Ala Tyr Ser Gly His Leu Asp Ile Val Gln Glu Leu Ile 
        115                 120                 125             


Ala Gln Gly Ala Asp Val His Ala Val Thr Val Asp Gly Trp Thr Pro 
    130                 135                 140                 


Leu His Ser Ala Cys Lys Trp Asn Asn Thr Arg Val Ala Ser Phe Leu 
145                 150                 155                 160 


Leu Gln His Asp Ala Asp Ile Asn Ala Gln Thr Lys Gly Leu Leu Thr 
                165                 170                 175     


Pro Leu His Leu Ala Ala Gly Asn Arg Asp Ser Lys Asp Thr Leu Glu 
            180                 185                 190         


Leu Leu Leu Met Asn Arg Tyr Val Lys Pro Gly Leu Lys Asn Asn Leu 
        195                 200                 205             


Glu Glu Thr Ala Phe Asp Ile Ala Arg Arg Thr Ser Ile Tyr His Tyr 
    210                 215                 220                 


Leu Phe Glu Ile Val Glu Gly Cys Thr Asn Ser Ser Pro Gln Ser 
225                 230                 235                 


<210>  81
<211>  5535
<212>  DNA
<213>  Homo sapiens

<400>  81
atggtggggg tcctggccat ggcggctgca gctgctccgc ctcccgtgaa ggactgcgag       60

attgagccat gcaaaaagcg aaagaaagat gatgacacat ctacctgcaa aacaattaca      120

aaatatttat caccactagg gaagactaga gacagggttt ttgctccacc aaaacctagt      180

aatattctgg attattttag aaagacttca cccacaaatg agaagacaca attagggaaa      240

gagtgcaaga taaagtcacc tgaatcagta cctgttgaca gcaacaaaga ctgtacgaca      300

cctttggaaa tgttctcaaa tgtagagttt aagaagaaaa gaaagagggt taatttatct      360

catcaactaa ataatattaa aactgaaaat gaagctccaa ttgaaattag tagcgacgat      420

agcaaagaag actatagttt aaataatgat tttgtggaaa gtagtacttc tgttttacgt      480

tacaagaaac aagtagaggt acttgcagaa aacattcaag atacaaaaag tcaaccaaat      540

actatgacct ccctgcaaaa ttctaaaaaa gtaaatccta aacaagggac cacaaaaaat      600

gacttcaaaa agttgagaaa aaggaaatgc agagatgtag tagatctatc tgaaagctta      660

cccttggcag aggaactaaa tttgcttaaa aaagatggta aagatactaa acagatggag      720

aatactacaa gccatgcaaa ctctagagat aacgtaactg aagcagccca gttaaatgat      780

agtataataa ctgtctcata tgaggaattt ttaaaaagtc acaaggaaaa taaagtggaa      840

gagataccag actctacaat gtcaatttgt gttccttctg aaactgtcga cgaaatagtc      900

aaaagtggtt atataagtga atcagaaaac tccgaaattt cccagcaggt acgctttaag      960

acagttactg ttcttgcaca ggttcaccct attccgccca aaaagacagg gaaaataccc     1020

cgaattttct tgaaacaaaa gcaatttgaa atggaaaata gtttatctga tcctgagaat     1080

gaacagacag ttcagaaaag aaaatctaat gttgttatac aggaggaaga attagaattg     1140

gctgttttgg aagctggaag ttctgaagct gtgaaaccaa aatgcactct agaagaaaga     1200

cagcaattta tgaaagcatt taggcagcca gcatcagatg cacttaaaaa tggagttaaa     1260

aagtcttctg ataagcagaa agaccttaat gaaaaatgtc tatatgaagt aggaagagat     1320

gataattcta aaaaaatcat ggaaaattct ggtatccaaa tggtttcaaa aaatggcaat     1380

ttacagttac acactgataa aggaagtttt ctgaaggaga aaaataaaaa gctaaagaag     1440

aagaataaga aaacattaga tactggggct attccaggca aaaacagaga gggaaacact     1500

caaaagaaag aaacaacctt tttcttaaaa gagaaacaat atcaaaatag aatgagttta     1560

agacaaagga aaacagagtt tttcaaaagc agcactttat ttaacaatga aagtcttgtt     1620

tatgaagata tagcaaatga tgaccttcta aaggtttcct ctctgtgtaa caataataaa     1680

ttgtcaagaa aaaccagcat accagttaaa gatattaagc ttacacagtc taaagctgaa     1740

tctgaagcca gcttgctaaa tgtttccacg cccaagtcaa ctagaagatc tggaagaatt     1800

agcagcacac ctactacaga aaccattaga ggtattgatt ctgacgatgt acaagataat     1860

agtcaactaa aggcttccac tcaaaaagca gccaacttat cggaaaagca cagcttatat     1920

acagcagaat taataacagt accctttgat tcagagagcc ctattagaat gaaattcacc     1980

agaattagta ctcccaaaaa atctaagaaa aaatctaaca aaagatctga gaaatctgaa     2040

gcaactgatg gaggttttac ttctcagatt agaaaggcaa gcaatacttc aaaaaacata     2100

tcaaaagcaa aacaattgat tgaaaaagca aaagctttac acatcagtag gtcaaaggtg     2160

actgaagaaa tagcgatacc cttaaggcgc tcctctagac atcagacact tcctgaaagg     2220

aagaaattgt cagaaacaga agattctgtt ataataatag attcaagtcc tactgcttta     2280

aagcatccag agaaaaatca gaagaaactt cagtgtttga atgatgtgct aggaaaaaaa     2340

cttaacacat ccactaaaaa tgtacctgga aaaatgaaag tcgctccttt atttcttgtc     2400

agaaaagcac aaaaagcagc tgatcctgtc cctagttttg atgaaagcag tcaagataca     2460

tctgaaaaat ctcaggattg tgatgttcaa tgtaaagcaa agcgtgactt cctaatgagt     2520

ggtttgccag atttgttgaa acggcaaatt gcaaagaaag ctgctgcgct ggatgtgtac     2580

aatgcagtga gtaccagttt ccagagagtc gtacatgtgc aacaaaagga tgatgggtgt     2640

tgtttgtggc atttgaaacc accctcttgt cctctcttaa ctaaatttaa agaactgaac     2700

actaaagtaa tagatctctc aaaatgtggt attgctcttg gtgaattttc aacattgaat     2760

tcaaagttga aaagcggtaa ctctgctgct gtgttcatga ggacaaggaa ggaatttact     2820

gaagaagtaa gaaatctttt gcttgaggaa attaggtggt caaatcctga attttcattg     2880

aaaaaatatt ttcccttact cctaaaaaaa caaattgagc accaagtact ttcttccgag     2940

tgtcatagta aacaagaact ggaggctgat gtcagccata aagaaaccaa aaggaaactc     3000

gtagaagcag aaaattctaa gtcaaaaaga aagaaaccaa atgagtattc aaaaaatctg     3060

gagaagacca ataggaagtc agaagaactt agcaaaagaa acaactcttc tgggataaag     3120

ctagattctt ccaaagattc tggaactgaa gacatgcttt ggacagaaaa gtatcaacct     3180

cagactgcca gtgaacttat aggaaatgag ttagctataa aaaagttaca tagttggttg     3240

aaagactgga aaagaagagc tgaattggaa gaaaggcaga atctgaaggg aaaaagagat     3300

gagaaacatg aagatttctc gggtggcata gactttaaag gcagttcaga tgatgaagaa     3360

gagagtcgtc tttgcaatac tgtccttata acagggccaa caggagtggg aaaaactgct     3420

gcagtgtatg cttgtgccca ggagcttgga tttaagatat ttgaagtgaa tgcctcttcc     3480

cagcgcagtg gtagacaaat tctatctcag ttgaaggaag ctactcagtc ccatcaagta     3540

gacaaacaag gtgtaaactc acaaaaaccc tgttttttta atagctacta cataggcaag     3600

tcaccaaaaa aaataagctc ccctaagaaa gttgttacat caccaagaaa agttcctcca     3660

ccatcaccaa aaagtagtgg accaaagcga gcacttcctc ccaaaacctt ggcaaattat     3720

tttaaagtat ctcccaaacc taaaaataat gaagaaatag gaatgcttct ggaaaataat     3780

aaaggaataa aaaattcttt tgaacagaaa caaattactc agactaaatc tacaaatgca     3840

actaattcaa atgtcaaaga cgttggagct gaagaaccca gcagaaaaaa tgcaacatct     3900

cttattcttt ttgaggaggt tgatgtaatt tttgatgaag atgctgggtt tttgaatgca     3960

atcaaaacat tcatggcaac aactaaacga cctgtaatcc ttactacaag tgacccaaca     4020

tttagtttaa tgtttgatgg ctgctttgaa gaaatcaagt tcagtactcc ttccctgcta     4080

aatgttgcca gctacctaca aatgatttgc ttaactgaga attttagaac tgatgtaaaa     4140

gactttgtaa ccttgttaac tgcaaatact tgtgatatca gaaaaagtat cctttactta     4200

caattctgga ttagaagtgg aggtggagtt ttagaagaac gaccattaac cctttatcgt     4260

ggaaatagca gaaatgtaca actagtttgc tctgaacatg gccttgataa caaaatttac     4320

cctaaaaata ctaaaaagaa acgtgtagac cttccaaaat gtgacagtgg ctgtgctgag     4380

accttgtttg gccttaagaa cattttttcc ccatctgaag acttattttc atttttaaag     4440

cacaaaatca caatgaagga agaatggcat aaattcatcc agcttcttac agaattccaa     4500

atgcggaatg tagatttttt atatagtaat cttgagttta ttctaccatt accagttgat     4560

accattccag aaactaaaaa cttttgtggc ccatcagtaa ctgtggatgc cagtgcagca     4620

acaaaaagta tgaattgtct tgctaggaaa cactctgaaa gagaacagcc attgaaaaag     4680

tcccagaaaa agaaacaaaa gaaaacattg gtaatattag atgatagtga tctatttgac     4740

actgacttgg actttcctga tcaatctatt agcctgtcct ctgtatcatc ttcctcaaat     4800

gcagaagaaa gcaaaaccgg agacgaagaa agcaaagcca gagacaaagg aaacaatcca     4860

gagacaaaga aatctattcc ttgtcctcct aaaacaactg caggaaaaaa atgttctgcc     4920

cttgtttctc attgtttaaa ttctctctct gagttcatgg ataacatgtc cttcttagat     4980

gcacttttaa ctgatgtaag ggaacaaaac aaatacggta gaaatgactt tagttggaca     5040

aatggaaagg ttacaagtgg actttgtgat gagtttagtc ttgagagtaa tgatggatgg     5100

acttctcaaa gctctggaga attaaaggca gctgcagaag ctctcagctt tactaaatgt     5160

tcttctgcta tttcaaaagc attggaaacc ttgaattctt gcaagaaatt aggaagagat     5220

ccaaccaacg atcttacttt ttatgtttca caaaagcgca ataatgtata ctttagtcag     5280

tcagcagcta atttagacaa tgcttggaag aggatatcag tcattaaaag tgtattttcg     5340

agtcgatctc ttctctatgt gggtaataga caagctagta taattgaata cctgccaacc     5400

cttcgaaaca tctgtaagac tgagaagcta aaagaacaag gaaaaagtaa aagaagattc     5460

ctgcactatt ttgaaggaat tcatcttgac attccaaaag agactgtgaa tactttggca     5520

gctgacttcc cttaa                                                      5535


<210>  82
<211>  1844
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val 
1               5                   10                  15      


Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp 
            20                  25                  30          


Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys 
        35                  40                  45              


Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys 
65                  70                  75                  80  


Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys 
                85                  90                  95      


Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys 
            100                 105                 110         


Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr 
        115                 120                 125             


Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp 
    130                 135                 140                 


Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg 
145                 150                 155                 160 


Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys 
                165                 170                 175     


Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn 
            180                 185                 190         


Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg 
        195                 200                 205             


Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu 
    210                 215                 220                 


Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu 
225                 230                 235                 240 


Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala 
                245                 250                 255     


Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys 
            260                 265                 270         


Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser 
        275                 280                 285             


Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr 
    290                 295                 300                 


Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys 
305                 310                 315                 320 


Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr 
                325                 330                 335     


Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu 
            340                 345                 350         


Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys 
        355                 360                 365             


Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu 
    370                 375                 380                 


Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg 
385                 390                 395                 400 


Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys 
                405                 410                 415     


Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys 
            420                 425                 430         


Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu 
        435                 440                 445             


Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His 
    450                 455                 460                 


Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys 
465                 470                 475                 480 


Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg 
                485                 490                 495     


Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys 
            500                 505                 510         


Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe 
        515                 520                 525             


Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile 
    530                 535                 540                 


Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys 
545                 550                 555                 560 


Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln 
                565                 570                 575     


Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys 
            580                 585                 590         


Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr 
        595                 600                 605             


Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys 
    610                 615                 620                 


Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr 
625                 630                 635                 640 


Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg 
                645                 650                 655     


Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser 
            660                 665                 670         


Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser 
        675                 680                 685             


Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys 
    690                 695                 700                 


Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val 
705                 710                 715                 720 


Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr 
                725                 730                 735     


Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile 
            740                 745                 750         


Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys 
        755                 760                 765             


Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser 
    770                 775                 780                 


Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val 
785                 790                 795                 800 


Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser 
                805                 810                 815     


Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys 
            820                 825                 830         


Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg 
        835                 840                 845             


Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser 
    850                 855                 860                 


Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys 
865                 870                 875                 880 


Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe 
                885                 890                 895     


Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala 
            900                 905                 910         


Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser 
        915                 920                 925             


Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu 
945                 950                 955                 960 


Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val 
                965                 970                 975     


Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser 
            980                 985                 990         


His Lys Glu Thr Lys Arg Lys Leu  Val Glu Ala Glu Asn  Ser Lys Ser 
        995                 1000                 1005             


Lys Arg  Lys Lys Pro Asn Glu  Tyr Ser Lys Asn Leu  Glu Lys Thr 
    1010                 1015                 1020             


Asn Arg  Lys Ser Glu Glu Leu  Ser Lys Arg Asn Asn  Ser Ser Gly 
    1025                 1030                 1035             


Ile Lys  Leu Asp Ser Ser Lys  Asp Ser Gly Thr Glu  Asp Met Leu 
    1040                 1045                 1050             


Trp Thr  Glu Lys Tyr Gln Pro  Gln Thr Ala Ser Glu  Leu Ile Gly 
    1055                 1060                 1065             


Asn Glu  Leu Ala Ile Lys Lys  Leu His Ser Trp Leu  Lys Asp Trp 
    1070                 1075                 1080             


Lys Arg  Arg Ala Glu Leu Glu  Glu Arg Gln Asn Leu  Lys Gly Lys 
    1085                 1090                 1095             


Arg Asp  Glu Lys His Glu Asp  Phe Ser Gly Gly Ile  Asp Phe Lys 
    1100                 1105                 1110             


Gly Ser  Ser Asp Asp Glu Glu  Glu Ser Arg Leu Cys  Asn Thr Val 
    1115                 1120                 1125             


Leu Ile  Thr Gly Pro Thr Gly  Val Gly Lys Thr Ala  Ala Val Tyr 
    1130                 1135                 1140             


Ala Cys  Ala Gln Glu Leu Gly  Phe Lys Ile Phe Glu  Val Asn Ala 
    1145                 1150                 1155             


Ser Ser  Gln Arg Ser Gly Arg  Gln Ile Leu Ser Gln  Leu Lys Glu 
    1160                 1165                 1170             


Ala Thr  Gln Ser His Gln Val  Asp Lys Gln Gly Val  Asn Ser Gln 
    1175                 1180                 1185             


Lys Pro  Cys Phe Phe Asn Ser  Tyr Tyr Ile Gly Lys  Ser Pro Lys 
    1190                 1195                 1200             


Lys Ile  Ser Ser Pro Lys Lys  Val Val Thr Ser Pro  Arg Lys Val 
    1205                 1210                 1215             


Pro Pro  Pro Ser Pro Lys Ser  Ser Gly Pro Lys Arg  Ala Leu Pro 
    1220                 1225                 1230             


Pro Lys  Thr Leu Ala Asn Tyr  Phe Lys Val Ser Pro  Lys Pro Lys 
    1235                 1240                 1245             


Asn Asn  Glu Glu Ile Gly Met  Leu Leu Glu Asn Asn  Lys Gly Ile 
    1250                 1255                 1260             


Lys Asn  Ser Phe Glu Gln Lys  Gln Ile Thr Gln Thr  Lys Ser Thr 
    1265                 1270                 1275             


Asn Ala  Thr Asn Ser Asn Val  Lys Asp Val Gly Ala  Glu Glu Pro 
    1280                 1285                 1290             


Ser Arg  Lys Asn Ala Thr Ser  Leu Ile Leu Phe Glu  Glu Val Asp 
    1295                 1300                 1305             


Val Ile  Phe Asp Glu Asp Ala  Gly Phe Leu Asn Ala  Ile Lys Thr 
    1310                 1315                 1320             


Phe Met  Ala Thr Thr Lys Arg  Pro Val Ile Leu Thr  Thr Ser Asp 
    1325                 1330                 1335             


Pro Thr  Phe Ser Leu Met Phe  Asp Gly Cys Phe Glu  Glu Ile Lys 
    1340                 1345                 1350             


Phe Ser  Thr Pro Ser Leu Leu  Asn Val Ala Ser Tyr  Leu Gln Met 
    1355                 1360                 1365             


Ile Cys  Leu Thr Glu Asn Phe  Arg Thr Asp Val Lys  Asp Phe Val 
    1370                 1375                 1380             


Thr Leu  Leu Thr Ala Asn Thr  Cys Asp Ile Arg Lys  Ser Ile Leu 
    1385                 1390                 1395             


Tyr Leu  Gln Phe Trp Ile Arg  Ser Gly Gly Gly Val  Leu Glu Glu 
    1400                 1405                 1410             


Arg Pro  Leu Thr Leu Tyr Arg  Gly Asn Ser Arg Asn  Val Gln Leu 
    1415                 1420                 1425             


Val Cys  Ser Glu His Gly Leu  Asp Asn Lys Ile Tyr  Pro Lys Asn 
    1430                 1435                 1440             


Thr Lys  Lys Lys Arg Val Asp  Leu Pro Lys Cys Asp  Ser Gly Cys 
    1445                 1450                 1455             


Ala Glu  Thr Leu Phe Gly Leu  Lys Asn Ile Phe Ser  Pro Ser Glu 
    1460                 1465                 1470             


Asp Leu  Phe Ser Phe Leu Lys  His Lys Ile Thr Met  Lys Glu Glu 
    1475                 1480                 1485             


Trp His  Lys Phe Ile Gln Leu  Leu Thr Glu Phe Gln  Met Arg Asn 
    1490                 1495                 1500             


Val Asp  Phe Leu Tyr Ser Asn  Leu Glu Phe Ile Leu  Pro Leu Pro 
    1505                 1510                 1515             


Val Asp  Thr Ile Pro Glu Thr  Lys Asn Phe Cys Gly  Pro Ser Val 
    1520                 1525                 1530             


Thr Val  Asp Ala Ser Ala Ala  Thr Lys Ser Met Asn  Cys Leu Ala 
    1535                 1540                 1545             


Arg Lys  His Ser Glu Arg Glu  Gln Pro Leu Lys Lys  Ser Gln Lys 
    1550                 1555                 1560             


Lys Lys  Gln Lys Lys Thr Leu  Val Ile Leu Asp Asp  Ser Asp Leu 
    1565                 1570                 1575             


Phe Asp  Thr Asp Leu Asp Phe  Pro Asp Gln Ser Ile  Ser Leu Ser 
    1580                 1585                 1590             


Ser Val  Ser Ser Ser Ser Asn  Ala Glu Glu Ser Lys  Thr Gly Asp 
    1595                 1600                 1605             


Glu Glu  Ser Lys Ala Arg Asp  Lys Gly Asn Asn Pro  Glu Thr Lys 
    1610                 1615                 1620             


Lys Ser  Ile Pro Cys Pro Pro  Lys Thr Thr Ala Gly  Lys Lys Cys 
    1625                 1630                 1635             


Ser Ala  Leu Val Ser His Cys  Leu Asn Ser Leu Ser  Glu Phe Met 
    1640                 1645                 1650             


Asp Asn  Met Ser Phe Leu Asp  Ala Leu Leu Thr Asp  Val Arg Glu 
    1655                 1660                 1665             


Gln Asn  Lys Tyr Gly Arg Asn  Asp Phe Ser Trp Thr  Asn Gly Lys 
    1670                 1675                 1680             


Val Thr  Ser Gly Leu Cys Asp  Glu Phe Ser Leu Glu  Ser Asn Asp 
    1685                 1690                 1695             


Gly Trp  Thr Ser Gln Ser Ser  Gly Glu Leu Lys Ala  Ala Ala Glu 
    1700                 1705                 1710             


Ala Leu  Ser Phe Thr Lys Cys  Ser Ser Ala Ile Ser  Lys Ala Leu 
    1715                 1720                 1725             


Glu Thr  Leu Asn Ser Cys Lys  Lys Leu Gly Arg Asp  Pro Thr Asn 
    1730                 1735                 1740             


Asp Leu  Thr Phe Tyr Val Ser  Gln Lys Arg Asn Asn  Val Tyr Phe 
    1745                 1750                 1755             


Ser Gln  Ser Ala Ala Asn Leu  Asp Asn Ala Trp Lys  Arg Ile Ser 
    1760                 1765                 1770             


Val Ile  Lys Ser Val Phe Ser  Ser Arg Ser Leu Leu  Tyr Val Gly 
    1775                 1780                 1785             


Asn Arg  Gln Ala Ser Ile Ile  Glu Tyr Leu Pro Thr  Leu Arg Asn 
    1790                 1795                 1800             


Ile Cys  Lys Thr Glu Lys Leu  Lys Glu Gln Gly Lys  Ser Lys Arg 
    1805                 1810                 1815             


Arg Phe  Leu His Tyr Phe Glu  Gly Ile His Leu Asp  Ile Pro Lys 
    1820                 1825                 1830             


Glu Thr  Val Asn Thr Leu Ala  Ala Asp Phe Pro 
    1835                 1840                 


<210>  83
<211>  1695
<212>  DNA
<213>  Homo sapiens

<400>  83
atggccagca catccaccac catcaggagc cacagcagca gccgccgggg tttcagtgcc       60

aactcagcca ggctccctgg ggtcagccgc tctggcttca gcagcgtctc cgtgtcccgc      120

tccaggggca gtggtggcct gggtggtgca tgtggaggag ctggctttgg cagccgcagt      180

ctgtatggcc tggggggctc caagaggatc tccattggag ggggcagctg tgccatcagt      240

ggcggctatg gcagcagagc cggaggcagc tatggctttg gtggcgccgg gagtggattt      300

ggtttcggtg gtggagccgg cattggcttt ggtctgggtg gtggagccgg ccttgctggt      360

ggctttgggg gccctggctt ccctgtgtgc ccccctggag gcatccaaga ggtcaccgtc      420

aaccagagtc tcctgactcc cctcaacctg caaatcgatc ccaccatcca gcgggtgcgg      480

gctgaggagc gtgaacagat caagaccctc aacaacaagt ttgcctcctt catcgacaag      540

gtgcggttcc tggagcagca gaacaaggtt ctggaaacaa agtggaccct gctgcaggag      600

cagggcacca agactgtgag gcagaacctg gagccgttgt tcgagcagta catcaacaac      660

ctcaggaggc agctggacag cattgtcggg gaacggggcc gcctggactc agagctcaga      720

ggcatgcagg acctggtgga ggacttcaag aacaaatatg aggatgaaat caacaagcgc      780

acagcagcag agaatgaatt tgtgactctg aagaaggatg tggatgctgc ctacatgaac      840

aaggttgaac tgcaagccaa ggcagacact ctcacagacg agatcaactt cctgagagcc      900

ttgtatgatg cagagctgtc ccagatgcag acccacatct cagacacatc tgtggtgctg      960

tccatggaca acaaccgcaa cctggacctg gacagcatca tcgctgaggt caaggcccaa     1020

tatgaggaga ttgctcagag aagccgggct gaggctgagt cctggtacca gaccaagtac     1080

gaggagctgc aggtcacagc aggcagacat ggggacgacc tgcgcaacac caagcaggag     1140

attgctgaga tcaaccgcat gatccagagg ctgagatctg agatcgacca cgtcaagaag     1200

cagtgcgcca acctgcaggc cgccattgct gatgctgagc agcgtgggga gatggccctc     1260

aaggatgcca agaacaagct ggaagggctg gaggatgccc tgcagaaggc caagcaggac     1320

ctggcccggc tgctgaagga gtaccaggag ctgatgaatg tcaagctggc cctggacgtg     1380

gagatcgcca cctaccgcaa gctgctggag ggtgaggagt gcaggctgaa tggcgaaggc     1440

gttggacaag tcaacatctc tgtggtgcag tccaccgtct ccagtggcta tggcggtgcc     1500

agtggtgtcg gcagtggctt aggcctgggt ggaggaagca gctactccta tggcagtggt     1560

cttggcgttg gaggtggctt cagttccagc agtggcagag ccattggggg tggcctcagc     1620

tctgttggag gcggcagttc caccatcaag tacaccacca cctcctcctc cagcaggaag     1680

agctataagc actaa                                                      1695


<210>  84
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  85
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  85
atgggttgga caatgaggct ggtcacagca gcactgttac tgggtctcat gatggtggtc       60

actggagacg aggatgagaa cagcccgtgt gcccatgagg ccctcttgga cgaggacacc      120

ctcttttgcc agggccttga agttttctac ccagagttgg ggaacattgg ctgcaaggtt      180

gttcctgatt gtaacaacta cagacagaag atcacctcct ggatggagcc gatagtcaag      240

ttcccggggg ccgtggacgg cgcaacctat atcctggtga tggtggatcc agatgcccct      300

agcagagcag aacccagaca gagattctgg agacattggc tggtaacaga tatcaagggc      360

gccgacctga agaaagggaa gattcagggc caggagttat cagcctacca ggctccctcc      420

ccaccggcac acagtggctt ccatcgctac cagttctttg tctatcttca ggaaggaaaa      480

gtcatctctc tccttcccaa ggaaaacaaa actcgaggct cttggaaaat ggacagattt      540

ctgaaccgtt tccacctggg cgaacctgaa gcaagcaccc agttcatgac ccagaactac      600

caggactcac caaccctcca ggctcccaga gaaagggcca gcgagcccaa gcacaaaaac      660

caggcggaga tagctgcctg ctag                                             684


<210>  86
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu 
1               5                   10                  15      


Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His 
            20                  25                  30          


Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gln Gly Leu Glu Val 
        35                  40                  45              


Phe Tyr Pro Glu Leu Gly Asn Ile Gly Cys Lys Val Val Pro Asp Cys 
    50                  55                  60                  


Asn Asn Tyr Arg Gln Lys Ile Thr Ser Trp Met Glu Pro Ile Val Lys 
65                  70                  75                  80  


Phe Pro Gly Ala Val Asp Gly Ala Thr Tyr Ile Leu Val Met Val Asp 
                85                  90                  95      


Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gln Arg Phe Trp Arg His 
            100                 105                 110         


Trp Leu Val Thr Asp Ile Lys Gly Ala Asp Leu Lys Lys Gly Lys Ile 
        115                 120                 125             


Gln Gly Gln Glu Leu Ser Ala Tyr Gln Ala Pro Ser Pro Pro Ala His 
    130                 135                 140                 


Ser Gly Phe His Arg Tyr Gln Phe Phe Val Tyr Leu Gln Glu Gly Lys 
145                 150                 155                 160 


Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 
                165                 170                 175     


Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser 
            180                 185                 190         


Thr Gln Phe Met Thr Gln Asn Tyr Gln Asp Ser Pro Thr Leu Gln Ala 
        195                 200                 205             


Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gln Ala Glu Ile 
    210                 215                 220                 


Ala Ala Cys 
225         


<210>  87
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  87
atgagctccc gcatcgccag ggcgctcgcc ttagtcgtca cccttctcca cttgaccagg       60

ctggcgctct ccacctgccc cgctgcctgc cactgccccc tggaggcgcc caagtgcgcg      120

ccgggagtcg ggctggtccg ggacggctgc ggctgctgta aggtctgcgc caagcagctc      180

aacgaggact gcagcaaaac gcagccctgc gaccacacca aggggctgga atgcaacttc      240

ggcgccagct ccaccgctct gaaggggatc tgcagagctc agtcagaggg cagaccctgt      300

gaatataact ccagaatcta ccaaaacggg gaaagtttcc agcccaactg taaacatcag      360

tgcacatgta ttgatggcgc cgtgggctgc attcctctgt gtccccaaga actatctctc      420

cccaacttgg gctgtcccaa ccctcggctg gtcaaagtta ccgggcagtg ctgcgaggag      480

tgggtctgtg acgaggatag tatcaaggac cccatggagg accaggacgg cctccttggc      540

aaggagctgg gattcgatgc ctccgaggtg gagttgacga gaaacaatga attgattgca      600

gttggaaaag gcagctcact gaagcggctc cctgtttttg gaatggagcc tcgcatccta      660

tacaaccctt tacaaggcca gaaatgtatt gttcaaacaa cttcatggtc ccagtgctca      720

aagacctgtg gaactggtat ctccacacga gttaccaatg acaaccctga gtgccgcctt      780

gtgaaagaaa cccggatttg tgaggtgcgg ccttgtggac agccagtgta cagcagcctg      840

aaaaagggca agaaatgcag caagaccaag aaatcccccg aaccagtcag gtttacttac      900

gctggatgtt tgagtgtgaa gaaataccgg cccaagtact gcggttcctg cgtggacggc      960

cgatgctgca cgccccagct gaccaggact gtgaagatgc ggttccgctg cgaagatggg     1020

gagacatttt ccaagaacgt catgatgatc cagtcctgca aatgcaacta caactgcccg     1080

catgccaatg aagcagcgtt tcccttctac aggctgttca atgacattca caaatttagg     1140

gactaa                                                                1146


<210>  88
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ser Ser Arg Ile Ala Arg Ala Leu Ala Leu Val Val Thr Leu Leu 
1               5                   10                  15      


His Leu Thr Arg Leu Ala Leu Ser Thr Cys Pro Ala Ala Cys His Cys 
            20                  25                  30          


Pro Leu Glu Ala Pro Lys Cys Ala Pro Gly Val Gly Leu Val Arg Asp 
        35                  40                  45              


Gly Cys Gly Cys Cys Lys Val Cys Ala Lys Gln Leu Asn Glu Asp Cys 
    50                  55                  60                  


Ser Lys Thr Gln Pro Cys Asp His Thr Lys Gly Leu Glu Cys Asn Phe 
65                  70                  75                  80  


Gly Ala Ser Ser Thr Ala Leu Lys Gly Ile Cys Arg Ala Gln Ser Glu 
                85                  90                  95      


Gly Arg Pro Cys Glu Tyr Asn Ser Arg Ile Tyr Gln Asn Gly Glu Ser 
            100                 105                 110         


Phe Gln Pro Asn Cys Lys His Gln Cys Thr Cys Ile Asp Gly Ala Val 
        115                 120                 125             


Gly Cys Ile Pro Leu Cys Pro Gln Glu Leu Ser Leu Pro Asn Leu Gly 
    130                 135                 140                 


Cys Pro Asn Pro Arg Leu Val Lys Val Thr Gly Gln Cys Cys Glu Glu 
145                 150                 155                 160 


Trp Val Cys Asp Glu Asp Ser Ile Lys Asp Pro Met Glu Asp Gln Asp 
                165                 170                 175     


Gly Leu Leu Gly Lys Glu Leu Gly Phe Asp Ala Ser Glu Val Glu Leu 
            180                 185                 190         


Thr Arg Asn Asn Glu Leu Ile Ala Val Gly Lys Gly Ser Ser Leu Lys 
        195                 200                 205             


Arg Leu Pro Val Phe Gly Met Glu Pro Arg Ile Leu Tyr Asn Pro Leu 
    210                 215                 220                 


Gln Gly Gln Lys Cys Ile Val Gln Thr Thr Ser Trp Ser Gln Cys Ser 
225                 230                 235                 240 


Lys Thr Cys Gly Thr Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Pro 
                245                 250                 255     


Glu Cys Arg Leu Val Lys Glu Thr Arg Ile Cys Glu Val Arg Pro Cys 
            260                 265                 270         


Gly Gln Pro Val Tyr Ser Ser Leu Lys Lys Gly Lys Lys Cys Ser Lys 
        275                 280                 285             


Thr Lys Lys Ser Pro Glu Pro Val Arg Phe Thr Tyr Ala Gly Cys Leu 
    290                 295                 300                 


Ser Val Lys Lys Tyr Arg Pro Lys Tyr Cys Gly Ser Cys Val Asp Gly 
305                 310                 315                 320 


Arg Cys Cys Thr Pro Gln Leu Thr Arg Thr Val Lys Met Arg Phe Arg 
                325                 330                 335     


Cys Glu Asp Gly Glu Thr Phe Ser Lys Asn Val Met Met Ile Gln Ser 
            340                 345                 350         


Cys Lys Cys Asn Tyr Asn Cys Pro His Ala Asn Glu Ala Ala Phe Pro 
        355                 360                 365             


Phe Tyr Arg Leu Phe Asn Asp Ile His Lys Phe Arg Asp 
    370                 375                 380     


<210>  89
<211>  1587
<212>  DNA
<213>  Homo sapiens

<400>  89
atgctgggcc ggagcctccg agaagtttct gcggcactga aacaaggcca aattacacca       60

acagagctct gtcaaaaatg tctctctctt atcaagaaga ccaagtttct aaatgcctac      120

attactgtgt cagaagaggt ggccttaaaa caagctgaag aatcagaaaa gagatataag      180

aatggacagt cacttgggga tttagatgga attcctattg cagtaaaaga caatttcagc      240

acttctggca ttgagacaac atgtgcatca aatatgctga aaggttatat accaccttat      300

aatgctacag tagttcagaa gttgttggat cagggagctc tactaatggg aaaaacaaat      360

ttagatgagt ttgctatggg atctgggagc acagatggtg tatttggacc agttaaaaac      420

ccctggagtt attcaaaaca atatagagaa aagaggaagc agaatcccca cagcgagaat      480

gaagattcag actggctgat aactggagga agctcaggtg ggagtgcagc tgctgtatcg      540

gcgttcacat gctacgcggc tttaggatca gatacaggag gatcgaccag aaatcctgct      600

gcccactgtg ggcttgttgg tttcaaacca agctatggct tagtttcccg tcatggtctc      660

attcccctgg tgaattcgat ggatgtgcca ggaatcttaa ccagatgtgt ggatgatgca      720

gcaattgtgt tgggtgcact ggccggacct gaccccaggg actctaccac agtacatgaa      780

cctattaata aaccattcat gcttcccagt ttggcagatg tgagcaaact atgtatagga      840

attccaaagg aatatcttgt accggaatta tcaagtgaag tacagtctct ttggtccaaa      900

gctgctgacc tctttgagtc tgagggggcc aaagtaattg aagtatccct tcctcacacc      960

agttattcaa ttgtctgcta ccatgtattg tgcacatcag aagtggcatc gaatatggca     1020

agatttgatg ggctacaata tggtcacaga tgtgacattg atgtgtccac tgaagccatg     1080

tatgctgcaa ccagacgaga agggtttaat gatgtggtga gaggaagaat tctctcagga     1140

aactttttct tattaaaaga aaactatgaa aattattttg tcaaagcaca gaaagtgaga     1200

cgcctcattg ctaatgactt tgtaaatgct tttaactctg gagtagatgt cttgctaact     1260

cccaccacct tgagtgaggc agtaccatac ttggagttca tcaaagagga caacagaacc     1320

cgaagtgccc aggatgatat ttttacacaa gctgtaaata tggcaggatt gccagcagtg     1380

agtatccctg ttgcactctc aaaccaaggg ttgccaatag gactgcagtt tattggacgt     1440

gcgttttgtg accagcagct tcttacagta gccaaatggt ttgaaaaaca agtacagttt     1500

cctgttattc aacttcaaga actcatggat gattgttcag cagtccttga aaatgaaaag     1560

ttagcctctg tctctctaaa acagtaa                                         1587


<210>  90
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Leu Gly Arg Ser Leu Arg Glu Val Ser Ala Ala Leu Lys Gln Gly 
1               5                   10                  15      


Gln Ile Thr Pro Thr Glu Leu Cys Gln Lys Cys Leu Ser Leu Ile Lys 
            20                  25                  30          


Lys Thr Lys Phe Leu Asn Ala Tyr Ile Thr Val Ser Glu Glu Val Ala 
        35                  40                  45              


Leu Lys Gln Ala Glu Glu Ser Glu Lys Arg Tyr Lys Asn Gly Gln Ser 
    50                  55                  60                  


Leu Gly Asp Leu Asp Gly Ile Pro Ile Ala Val Lys Asp Asn Phe Ser 
65                  70                  75                  80  


Thr Ser Gly Ile Glu Thr Thr Cys Ala Ser Asn Met Leu Lys Gly Tyr 
                85                  90                  95      


Ile Pro Pro Tyr Asn Ala Thr Val Val Gln Lys Leu Leu Asp Gln Gly 
            100                 105                 110         


Ala Leu Leu Met Gly Lys Thr Asn Leu Asp Glu Phe Ala Met Gly Ser 
        115                 120                 125             


Gly Ser Thr Asp Gly Val Phe Gly Pro Val Lys Asn Pro Trp Ser Tyr 
    130                 135                 140                 


Ser Lys Gln Tyr Arg Glu Lys Arg Lys Gln Asn Pro His Ser Glu Asn 
145                 150                 155                 160 


Glu Asp Ser Asp Trp Leu Ile Thr Gly Gly Ser Ser Gly Gly Ser Ala 
                165                 170                 175     


Ala Ala Val Ser Ala Phe Thr Cys Tyr Ala Ala Leu Gly Ser Asp Thr 
            180                 185                 190         


Gly Gly Ser Thr Arg Asn Pro Ala Ala His Cys Gly Leu Val Gly Phe 
        195                 200                 205             


Lys Pro Ser Tyr Gly Leu Val Ser Arg His Gly Leu Ile Pro Leu Val 
    210                 215                 220                 


Asn Ser Met Asp Val Pro Gly Ile Leu Thr Arg Cys Val Asp Asp Ala 
225                 230                 235                 240 


Ala Ile Val Leu Gly Ala Leu Ala Gly Pro Asp Pro Arg Asp Ser Thr 
                245                 250                 255     


Thr Val His Glu Pro Ile Asn Lys Pro Phe Met Leu Pro Ser Leu Ala 
            260                 265                 270         


Asp Val Ser Lys Leu Cys Ile Gly Ile Pro Lys Glu Tyr Leu Val Pro 
        275                 280                 285             


Glu Leu Ser Ser Glu Val Gln Ser Leu Trp Ser Lys Ala Ala Asp Leu 
    290                 295                 300                 


Phe Glu Ser Glu Gly Ala Lys Val Ile Glu Val Ser Leu Pro His Thr 
305                 310                 315                 320 


Ser Tyr Ser Ile Val Cys Tyr His Val Leu Cys Thr Ser Glu Val Ala 
                325                 330                 335     


Ser Asn Met Ala Arg Phe Asp Gly Leu Gln Tyr Gly His Arg Cys Asp 
            340                 345                 350         


Ile Asp Val Ser Thr Glu Ala Met Tyr Ala Ala Thr Arg Arg Glu Gly 
        355                 360                 365             


Phe Asn Asp Val Val Arg Gly Arg Ile Leu Ser Gly Asn Phe Phe Leu 
    370                 375                 380                 


Leu Lys Glu Asn Tyr Glu Asn Tyr Phe Val Lys Ala Gln Lys Val Arg 
385                 390                 395                 400 


Arg Leu Ile Ala Asn Asp Phe Val Asn Ala Phe Asn Ser Gly Val Asp 
                405                 410                 415     


Val Leu Leu Thr Pro Thr Thr Leu Ser Glu Ala Val Pro Tyr Leu Glu 
            420                 425                 430         


Phe Ile Lys Glu Asp Asn Arg Thr Arg Ser Ala Gln Asp Asp Ile Phe 
        435                 440                 445             


Thr Gln Ala Val Asn Met Ala Gly Leu Pro Ala Val Ser Ile Pro Val 
    450                 455                 460                 


Ala Leu Ser Asn Gln Gly Leu Pro Ile Gly Leu Gln Phe Ile Gly Arg 
465                 470                 475                 480 


Ala Phe Cys Asp Gln Gln Leu Leu Thr Val Ala Lys Trp Phe Glu Lys 
                485                 490                 495     


Gln Val Gln Phe Pro Val Ile Gln Leu Gln Glu Leu Met Asp Asp Cys 
            500                 505                 510         


Ser Ala Val Leu Glu Asn Glu Lys Leu Ala Ser Val Ser Leu Lys Gln 
        515                 520                 525             


<210>  91
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  91
atggaggaag gaggcggcgg cgtacggagt ctggtcccgg gcgggccggt gttactggtc       60

ctctgcggcc tcctggaggc gtccggcggc ggccgagccc ttcctcaact cagcgatgac      120

atccctttcc gagtcaactg gcccggcacc gagttctctc tgcccacaac tggagtttta      180

tataaagaag ataattatgt catcatgaca actgcacata aagaaaaata taaatgcata      240

cttccccttg tgacaagtgg ggatgaggaa gaagaaaagg attataaagg ccctaatcca      300

agagagcttt tggagccact atttaaacaa agcagttgtt cctacagaat tgagtcttat      360

tggacttacg aagtatgtca tggaaaacac attcggcagt accatgaaga gaaagaaact      420

ggtcagaaaa taaatattca cgagtactac cttgggaata tgttggccaa gaaccttcta      480

tttgaaaaag aacgagaagc agaagaaaag gaaaaatcaa atgagattcc cactaaaaat      540

atcgaaggtc agatgacacc atactatcct gtgggaatgg gaaatggtac accttgtagt      600

ttgaaacaga accggcccag atcaagtact gtgatgtaca tatgtcatcc tgaatctaag      660

catgaaattc tttcagtagc tgaagttaca acttgtgaat atgaagttgt cattttgaca      720

ccactcttgt gcagtcatcc taaatatagg ttcagagcat ctcctgtgaa tgacatattt      780

tgtcaatcac tgccaggatc tccatttaag cccctcaccc tgaggcagct ggagcagcag      840

gaagaaatac taagggtgcc ttttaggaga aataaagagg aagatttgca atcaactaaa      900

gaagagagat ttccagcgat ccacaagtcg attgctattg gctctcagcc agtgctcact      960

gttgggacaa cccacatatc caaattgaca gatgaccaac tcataaaaga gtttcttagt     1020

ggttcttact gctttcgtgg gggtgtcggt tggtggaaat atgaattctg ctatggcaaa     1080

catgtacatc aataccatga ggacaaggat agtgggaaaa cctctgtggt tgtcgggaca     1140

tggaaccaag aagagcatat tgaatgggct aagaagaata ctgctagagc ttatcatctt     1200

caagacgatg gtacccagac agtcaggatg gtgtcacatt tttatggaaa tggagatatt     1260

tgtgatataa ctgacaaacc aagacaggtg actgtaaaac taaagtgcaa agaatcagat     1320

tcacctcatg ctgttactgt atatatgcta gagcctcact cctgtcaata tattcttggg     1380

gttgaatctc cagtgatctg taaaatctta gatacagcag atgaaaatgg acttctttct     1440

ctccccaact aa                                                         1452


<210>  92
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val Pro Gly Gly Pro 
1               5                   10                  15      


Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser Gly Gly Gly Arg 
            20                  25                  30          


Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg Val Asn Trp Pro 
        35                  40                  45              


Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys Tyr Lys Cys Ile 
65                  70                  75                  80  


Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu Lys Asp Tyr Lys 
                85                  90                  95      


Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe Lys Gln Ser Ser 
            100                 105                 110         


Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu Val Cys His Gly 
        115                 120                 125             


Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr Gly Gln Lys Ile 
    130                 135                 140                 


Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala Lys Asn Leu Leu 
145                 150                 155                 160 


Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys Ser Asn Glu Ile 
                165                 170                 175     


Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr Tyr Pro Val Gly 
            180                 185                 190         


Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn Arg Pro Arg Ser 
        195                 200                 205             


Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys His Glu Ile Leu 
    210                 215                 220                 


Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val Ile Leu Thr 
225                 230                 235                 240 


Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val 
                245                 250                 255     


Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu 
            260                 265                 270         


Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu Arg Val Pro Phe 
        275                 280                 285             


Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys Glu Glu Arg Phe 
    290                 295                 300                 


Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln Pro Val Leu Thr 
305                 310                 315                 320 


Val Gly Thr Thr His Ile Ser Lys Leu Thr Asp Asp Gln Leu Ile Lys 
                325                 330                 335     


Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp 
            340                 345                 350         


Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln Tyr His Glu Asp 
        355                 360                 365             


Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gln Glu 
    370                 375                 380                 


Glu His Ile Glu Trp Ala Lys Lys Asn Thr Ala Arg Ala Tyr His Leu 
385                 390                 395                 400 


Gln Asp Asp Gly Thr Gln Thr Val Arg Met Val Ser His Phe Tyr Gly 
                405                 410                 415     


Asn Gly Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg Gln Val Thr Val 
            420                 425                 430         


Lys Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr 
        435                 440                 445             


Met Leu Glu Pro His Ser Cys Gln Tyr Ile Leu Gly Val Glu Ser Pro 
    450                 455                 460                 


Val Ile Cys Lys Ile Leu Asp Thr Ala Asp Glu Asn Gly Leu Leu Ser 
465                 470                 475                 480 


Leu Pro Asn 
            


<210>  93
<211>  1830
<212>  DNA
<213>  Homo sapiens

<400>  93
atggagtcca cagcctaccc tctcaatttg agcctgaaag aagaggaaga ggaagaagag       60

attcagagcc gggaactaga ggacggcccg gcagacatgc agaaagtacg aatctgctct      120

gagggcggat gggtaccggc cctatttgat gaggtggcca tatatttttc cgatgaggaa      180

tgggaagttt tgacggagca acaaaaggcc ctctaccggg aagtcatgag gatgaattat      240

gaaactgtcc tgtccctgga attcccattc cctaagccag acatgatcac ccgtttggaa      300

ggggaggagg agtctcagaa ttctgacgag tggcagctcc aaggaggcac ctctgcagaa      360

aatgaagaat ctgacgtaaa gcctccagac tggccaaacc caatgaatgc tacctcccag      420

tttcctcagc ctcagcactt tgacagcttt ggcctccgtc tgcctcggga tatcacagag      480

ctgcccgagt ggagtgaggg gtaccccttc tacatggcca tgggcttccc agggtatgac      540

ctctcggctg atgacatagc tgggaagttt cagttcagcc ggggcatgcg ccgcagttac      600

gacgcagggt tcaagctgat ggtagtggaa tatgctgaga gtaccaacaa ctgccaggct      660

gccaagcagt ttggagtatt ggaaaaaaac gttcgagact ggcgcaaagt gaagccacag      720

cttcaaaacg cccacgccat gcggcgggca ttccgaggcc ccaagaatgg gaggtttgct      780

ctggtggacc agcgtgtggc cgaatatgtc agatacatgc aggccaaagg ggaccccatc      840

acccgggagg cgatgcagct gaaagctctc gaaatcgccc aggaaatgaa cattccagag      900

aaagggttca aggcaagctt gggttggtgt cgaagaatga tgagaaggta tgacctgtct      960

ctgaggcata aagtgcccgt gccccagcac ctgccggaag acctgactga gaaactcgtc     1020

acttaccagc gcagtgtcct ggctctgcgc agggcgcatg actatgaggt agctcagatg     1080

gggaatgcag atgagacgcc catttgttta gaggtgccat cacgggtaac tgttgataac     1140

cagggcgaaa agcctgtctt ggtcaagaca ccaggcaggg aaaaactgaa aatcacagca     1200

atgcttggtg tcttggctga tgggaggaag ttaccaccgt acatcatttt gaggggaaca     1260

tatatccccc cggggaagtt tcccagtggg atggaaattc gctgccaccg gtatgggtgg     1320

atgactgaag acttgatgca ggactggttg gaagtggtgt ggagacggag gacaggagca     1380

gtgcccaagc agcgagggat gctgatcttg aatggcttcc ggggccatgc cacagattcc     1440

gtgaagaact ccatggaaag catgaacact gacatggtga tcatcccagg gggtctgacc     1500

tcacagcttc aggtgctgga tgtcgtggtc tacaagccac tgaatgacag tgtgcgggcc     1560

cagtactcca actggcttct ggctgggaac ctggcgctga gcccaaccgg gaatgctaag     1620

aagccacccc tgggcctctt tctggagtgg gtcatggtcg cgtggaatag catctcaagt     1680

gagtccatcg tccaagggtt caagaagtgc catatctcca gcaacttgga ggaggaagac     1740

gatgtcctgt gggaaatcga gagtgagttg ccaggaggag gagaaccacc aaaagattgt     1800

gacaccgaaa gcatggctga gagcaactga                                      1830


<210>  94
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Glu Ser Thr Ala Tyr Pro Leu Asn Leu Ser Leu Lys Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Ile Gln Ser Arg Glu Leu Glu Asp Gly Pro Ala Asp 
            20                  25                  30          


Met Gln Lys Val Arg Ile Cys Ser Glu Gly Gly Trp Val Pro Ala Leu 
        35                  40                  45              


Phe Asp Glu Val Ala Ile Tyr Phe Ser Asp Glu Glu Trp Glu Val Leu 
    50                  55                  60                  


Thr Glu Gln Gln Lys Ala Leu Tyr Arg Glu Val Met Arg Met Asn Tyr 
65                  70                  75                  80  


Glu Thr Val Leu Ser Leu Glu Phe Pro Phe Pro Lys Pro Asp Met Ile 
                85                  90                  95      


Thr Arg Leu Glu Gly Glu Glu Glu Ser Gln Asn Ser Asp Glu Trp Gln 
            100                 105                 110         


Leu Gln Gly Gly Thr Ser Ala Glu Asn Glu Glu Ser Asp Val Lys Pro 
        115                 120                 125             


Pro Asp Trp Pro Asn Pro Met Asn Ala Thr Ser Gln Phe Pro Gln Pro 
    130                 135                 140                 


Gln His Phe Asp Ser Phe Gly Leu Arg Leu Pro Arg Asp Ile Thr Glu 
145                 150                 155                 160 


Leu Pro Glu Trp Ser Glu Gly Tyr Pro Phe Tyr Met Ala Met Gly Phe 
                165                 170                 175     


Pro Gly Tyr Asp Leu Ser Ala Asp Asp Ile Ala Gly Lys Phe Gln Phe 
            180                 185                 190         


Ser Arg Gly Met Arg Arg Ser Tyr Asp Ala Gly Phe Lys Leu Met Val 
        195                 200                 205             


Val Glu Tyr Ala Glu Ser Thr Asn Asn Cys Gln Ala Ala Lys Gln Phe 
    210                 215                 220                 


Gly Val Leu Glu Lys Asn Val Arg Asp Trp Arg Lys Val Lys Pro Gln 
225                 230                 235                 240 


Leu Gln Asn Ala His Ala Met Arg Arg Ala Phe Arg Gly Pro Lys Asn 
                245                 250                 255     


Gly Arg Phe Ala Leu Val Asp Gln Arg Val Ala Glu Tyr Val Arg Tyr 
            260                 265                 270         


Met Gln Ala Lys Gly Asp Pro Ile Thr Arg Glu Ala Met Gln Leu Lys 
        275                 280                 285             


Ala Leu Glu Ile Ala Gln Glu Met Asn Ile Pro Glu Lys Gly Phe Lys 
    290                 295                 300                 


Ala Ser Leu Gly Trp Cys Arg Arg Met Met Arg Arg Tyr Asp Leu Ser 
305                 310                 315                 320 


Leu Arg His Lys Val Pro Val Pro Gln His Leu Pro Glu Asp Leu Thr 
                325                 330                 335     


Glu Lys Leu Val Thr Tyr Gln Arg Ser Val Leu Ala Leu Arg Arg Ala 
            340                 345                 350         


His Asp Tyr Glu Val Ala Gln Met Gly Asn Ala Asp Glu Thr Pro Ile 
        355                 360                 365             


Cys Leu Glu Val Pro Ser Arg Val Thr Val Asp Asn Gln Gly Glu Lys 
    370                 375                 380                 


Pro Val Leu Val Lys Thr Pro Gly Arg Glu Lys Leu Lys Ile Thr Ala 
385                 390                 395                 400 


Met Leu Gly Val Leu Ala Asp Gly Arg Lys Leu Pro Pro Tyr Ile Ile 
                405                 410                 415     


Leu Arg Gly Thr Tyr Ile Pro Pro Gly Lys Phe Pro Ser Gly Met Glu 
            420                 425                 430         


Ile Arg Cys His Arg Tyr Gly Trp Met Thr Glu Asp Leu Met Gln Asp 
        435                 440                 445             


Trp Leu Glu Val Val Trp Arg Arg Arg Thr Gly Ala Val Pro Lys Gln 
    450                 455                 460                 


Arg Gly Met Leu Ile Leu Asn Gly Phe Arg Gly His Ala Thr Asp Ser 
465                 470                 475                 480 


Val Lys Asn Ser Met Glu Ser Met Asn Thr Asp Met Val Ile Ile Pro 
                485                 490                 495     


Gly Gly Leu Thr Ser Gln Leu Gln Val Leu Asp Val Val Val Tyr Lys 
            500                 505                 510         


Pro Leu Asn Asp Ser Val Arg Ala Gln Tyr Ser Asn Trp Leu Leu Ala 
        515                 520                 525             


Gly Asn Leu Ala Leu Ser Pro Thr Gly Asn Ala Lys Lys Pro Pro Leu 
    530                 535                 540                 


Gly Leu Phe Leu Glu Trp Val Met Val Ala Trp Asn Ser Ile Ser Ser 
545                 550                 555                 560 


Glu Ser Ile Val Gln Gly Phe Lys Lys Cys His Ile Ser Ser Asn Leu 
                565                 570                 575     


Glu Glu Glu Asp Asp Val Leu Trp Glu Ile Glu Ser Glu Leu Pro Gly 
            580                 585                 590         


Gly Gly Glu Pro Pro Lys Asp Cys Asp Thr Glu Ser Met Ala Glu Ser 
        595                 600                 605             


Asn 
    


<210>  95
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  95
atggctttag cagataagag acttgagaac ttacagatct acaaagttct tcaatgtgtg       60

cggaacaaag acaagaagca gatagagaag ctgaccaagc ttggataccc tgaactaatc      120

aattatacag aacccattaa tggacttagt gctttgcact tagcctcagt ttccaatgat      180

attgatatgg tcagctttct ccttgacctt ggtgctcacc ctgatgtgca agaccgaatg      240

ggctgtactc ccacaatgag ggctgcagaa ctgggccatg aattgtcaat ggaaatatta      300

gcaaaggcaa aggctgatat gactatagtt gataatgaag gaaaaggtgt tttgttttac      360

tgcattttac cgactaagcg gcattatcgc tgtgctctga tcgcccttga acatggtgca      420

gatgtcaaca attctaccta tgaaggaaag ccaatattcc ttagagcttg tgaagatgca      480

catgatgtta aagatgtgtg cctgacattt ttggaaaaag gagccaatcc taatgcaatc      540

aactcatcca caggccgcac agctttaatg gaagcgtcaa gagaaggggt agtggaaata      600

gttcgaggca tattggaaag aggaggtgaa gtgaatgcat ttgacaacga caggcatcac      660

gctgctcatt ttgctgctaa aggaggcttt ttcgatatat tgaagcttct ttttgcctac      720

aatggagacg tggggctgat ttcgataaat gggaacacac cacttcatta tgctgccatg      780

ggtggttttg cagactgctg taaatatata gctcagcgag gatgtgacct gaaatggaag      840

aatttagatc ataaaacgcc cagggctgtg gctaaggaag gcggcttcaa agcagcaagc      900

aaagaaatac gccgagcaga gagaatcgct aataaactag ccaggccagg agccaaaaat      960

ccaaatccac tgtgggccct tagactgcac gattggtccg tagaacgtga ggctttcctc     1020

cgggaagcct ttgcggtttt agacaggggt gatggaagca tcagcaagaa cgacttcgtg     1080

atggtgttgg aggaaaggca ggattatgca agctcagaac agctggctgc catcgctcac     1140

cttcatgaga aaacccgggg aggaggggtc aatattaatg aattctttaa aggaaccaga     1200

tatttaaaca agtcttttgt cttaggatcg tatggaccta agaaaaagga aaaagggatg     1260

ggcaaaaaag gaaagaaagg gaaatttgtc ttaccccttc caatctgtgt cattcctgag     1320

tacgcgtttc cacgccggca ggatggtggg ccaccgtatt acatgattga gacctacaag     1380

aatgtcactg atagcagccg gtttaataga gatcatcccc cagaacatcc cattcaggat     1440

gactctgttt ggtacattga tgattcagag aaggtatttt caaacattaa tattatcacc     1500

aaagcagggg atctggcttc tctgaaaaag gcctttgaat caggaatacc tgtggatatg     1560

aaggataatt attacaaaac tccgctaatg acggcgtgtg caagtggaaa catagatgtg     1620

gtcaagtttc ttcttgaaaa aggagctaac gttaatgcaa cagataactt tctgtggact     1680

ccacttcatt ttgcatgcca tgcaggccaa caagacattg ttgagcttct tgttgaatct     1740

ggagctttaa tagatgcagc ttcaatcaac aactcaactc ctttaaatag agccattgaa     1800

agctgcagac tggatacagt aaaataccta cttgatattg gtgctaaatt ccagctggaa     1860

aatagaaaag ggcatagtgc catggacgtt gcaaaggcat atgctgatta tagaataatt     1920

gatctgatta aagaaaagct agataacttg ccgaaaccag cagaaaatca aaaactaaaa     1980

ggcaagacac ctcctatact gaagactgaa ggccctgaaa ttaagaaaga agaggaactg     2040

ctgtcatcaa tttatggtgt accaaccaca tcagagggaa agaaagtaca gaagggtaat     2100

gtggttcatc tgaattcatt gattaccagt ggttatacta agaaagtgga tatcacattt     2160

attccacgga ggatttggag tcctgaagcc acaacagcag agctgatcag gaagagggaa     2220

ctacggcgag agaggtttac acatgaggtg gacttcgacg attttatgat gccttttcag     2280

aagaacatca cagagaaagc tcgagcactg gaagctgcct tgaagaccta a              2331


<210>  96
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Leu Ala Asp Lys Arg Leu Glu Asn Leu Gln Ile Tyr Lys Val 
1               5                   10                  15      


Leu Gln Cys Val Arg Asn Lys Asp Lys Lys Gln Ile Glu Lys Leu Thr 
            20                  25                  30          


Lys Leu Gly Tyr Pro Glu Leu Ile Asn Tyr Thr Glu Pro Ile Asn Gly 
        35                  40                  45              


Leu Ser Ala Leu His Leu Ala Ser Val Ser Asn Asp Ile Asp Met Val 
    50                  55                  60                  


Ser Phe Leu Leu Asp Leu Gly Ala His Pro Asp Val Gln Asp Arg Met 
65                  70                  75                  80  


Gly Cys Thr Pro Thr Met Arg Ala Ala Glu Leu Gly His Glu Leu Ser 
                85                  90                  95      


Met Glu Ile Leu Ala Lys Ala Lys Ala Asp Met Thr Ile Val Asp Asn 
            100                 105                 110         


Glu Gly Lys Gly Val Leu Phe Tyr Cys Ile Leu Pro Thr Lys Arg His 
        115                 120                 125             


Tyr Arg Cys Ala Leu Ile Ala Leu Glu His Gly Ala Asp Val Asn Asn 
    130                 135                 140                 


Ser Thr Tyr Glu Gly Lys Pro Ile Phe Leu Arg Ala Cys Glu Asp Ala 
145                 150                 155                 160 


His Asp Val Lys Asp Val Cys Leu Thr Phe Leu Glu Lys Gly Ala Asn 
                165                 170                 175     


Pro Asn Ala Ile Asn Ser Ser Thr Gly Arg Thr Ala Leu Met Glu Ala 
            180                 185                 190         


Ser Arg Glu Gly Val Val Glu Ile Val Arg Gly Ile Leu Glu Arg Gly 
        195                 200                 205             


Gly Glu Val Asn Ala Phe Asp Asn Asp Arg His His Ala Ala His Phe 
    210                 215                 220                 


Ala Ala Lys Gly Gly Phe Phe Asp Ile Leu Lys Leu Leu Phe Ala Tyr 
225                 230                 235                 240 


Asn Gly Asp Val Gly Leu Ile Ser Ile Asn Gly Asn Thr Pro Leu His 
                245                 250                 255     


Tyr Ala Ala Met Gly Gly Phe Ala Asp Cys Cys Lys Tyr Ile Ala Gln 
            260                 265                 270         


Arg Gly Cys Asp Leu Lys Trp Lys Asn Leu Asp His Lys Thr Pro Arg 
        275                 280                 285             


Ala Val Ala Lys Glu Gly Gly Phe Lys Ala Ala Ser Lys Glu Ile Arg 
    290                 295                 300                 


Arg Ala Glu Arg Ile Ala Asn Lys Leu Ala Arg Pro Gly Ala Lys Asn 
305                 310                 315                 320 


Pro Asn Pro Leu Trp Ala Leu Arg Leu His Asp Trp Ser Val Glu Arg 
                325                 330                 335     


Glu Ala Phe Leu Arg Glu Ala Phe Ala Val Leu Asp Arg Gly Asp Gly 
            340                 345                 350         


Ser Ile Ser Lys Asn Asp Phe Val Met Val Leu Glu Glu Arg Gln Asp 
        355                 360                 365             


Tyr Ala Ser Ser Glu Gln Leu Ala Ala Ile Ala His Leu His Glu Lys 
    370                 375                 380                 


Thr Arg Gly Gly Gly Val Asn Ile Asn Glu Phe Phe Lys Gly Thr Arg 
385                 390                 395                 400 


Tyr Leu Asn Lys Ser Phe Val Leu Gly Ser Tyr Gly Pro Lys Lys Lys 
                405                 410                 415     


Glu Lys Gly Met Gly Lys Lys Gly Lys Lys Gly Lys Phe Val Leu Pro 
            420                 425                 430         


Leu Pro Ile Cys Val Ile Pro Glu Tyr Ala Phe Pro Arg Arg Gln Asp 
        435                 440                 445             


Gly Gly Pro Pro Tyr Tyr Met Ile Glu Thr Tyr Lys Asn Val Thr Asp 
    450                 455                 460                 


Ser Ser Arg Phe Asn Arg Asp His Pro Pro Glu His Pro Ile Gln Asp 
465                 470                 475                 480 


Asp Ser Val Trp Tyr Ile Asp Asp Ser Glu Lys Val Phe Ser Asn Ile 
                485                 490                 495     


Asn Ile Ile Thr Lys Ala Gly Asp Leu Ala Ser Leu Lys Lys Ala Phe 
            500                 505                 510         


Glu Ser Gly Ile Pro Val Asp Met Lys Asp Asn Tyr Tyr Lys Thr Pro 
        515                 520                 525             


Leu Met Thr Ala Cys Ala Ser Gly Asn Ile Asp Val Val Lys Phe Leu 
    530                 535                 540                 


Leu Glu Lys Gly Ala Asn Val Asn Ala Thr Asp Asn Phe Leu Trp Thr 
545                 550                 555                 560 


Pro Leu His Phe Ala Cys His Ala Gly Gln Gln Asp Ile Val Glu Leu 
                565                 570                 575     


Leu Val Glu Ser Gly Ala Leu Ile Asp Ala Ala Ser Ile Asn Asn Ser 
            580                 585                 590         


Thr Pro Leu Asn Arg Ala Ile Glu Ser Cys Arg Leu Asp Thr Val Lys 
        595                 600                 605             


Tyr Leu Leu Asp Ile Gly Ala Lys Phe Gln Leu Glu Asn Arg Lys Gly 
    610                 615                 620                 


His Ser Ala Met Asp Val Ala Lys Ala Tyr Ala Asp Tyr Arg Ile Ile 
625                 630                 635                 640 


Asp Leu Ile Lys Glu Lys Leu Asp Asn Leu Pro Lys Pro Ala Glu Asn 
                645                 650                 655     


Gln Lys Leu Lys Gly Lys Thr Pro Pro Ile Leu Lys Thr Glu Gly Pro 
            660                 665                 670         


Glu Ile Lys Lys Glu Glu Glu Leu Leu Ser Ser Ile Tyr Gly Val Pro 
        675                 680                 685             


Thr Thr Ser Glu Gly Lys Lys Val Gln Lys Gly Asn Val Val His Leu 
    690                 695                 700                 


Asn Ser Leu Ile Thr Ser Gly Tyr Thr Lys Lys Val Asp Ile Thr Phe 
705                 710                 715                 720 


Ile Pro Arg Arg Ile Trp Ser Pro Glu Ala Thr Thr Ala Glu Leu Ile 
                725                 730                 735     


Arg Lys Arg Glu Leu Arg Arg Glu Arg Phe Thr His Glu Val Asp Phe 
            740                 745                 750         


Asp Asp Phe Met Met Pro Phe Gln Lys Asn Ile Thr Glu Lys Ala Arg 
        755                 760                 765             


Ala Leu Glu Ala Ala Leu Lys Thr 
    770                 775     


<210>  97
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  97
atggccctga acaatgtgtc cctgtcctcc ggtgatcaga ggagcagggt ggcctaccgc       60

tcttcccatg gcgacctcag accgcgggcg tcagcgttgg cgatggtctc cggagacggc      120

ttcctcgttt ccaggcctga agcgattcat ctaggacctc ggcaggcggt gcgaccaagc      180

gttcgggccg agagccgtcg agtggatggt ggcggccgga gcccaaggga accagatggc      240

cggggccgga gccgccaagc cagattctca ccttacccaa tccctgccgt tgaacccgat      300

ctcctaagaa gtgtgctgca acagcgtttg attgcattag gaggtgttat cgcagctcga      360

atttcagttt aa                                                          372


<210>  98
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly Asp Gln Arg Ser Arg 
1               5                   10                  15      


Val Ala Tyr Arg Ser Ser His Gly Asp Leu Arg Pro Arg Ala Ser Ala 
            20                  25                  30          


Leu Ala Met Val Ser Gly Asp Gly Phe Leu Val Ser Arg Pro Glu Ala 
        35                  40                  45              


Ile His Leu Gly Pro Arg Gln Ala Val Arg Pro Ser Val Arg Ala Glu 
    50                  55                  60                  


Ser Arg Arg Val Asp Gly Gly Gly Arg Ser Pro Arg Glu Pro Asp Gly 
65                  70                  75                  80  


Arg Gly Arg Ser Arg Gln Ala Arg Phe Ser Pro Tyr Pro Ile Pro Ala 
                85                  90                  95      


Val Glu Pro Asp Leu Leu Arg Ser Val Leu Gln Gln Arg Leu Ile Ala 
            100                 105                 110         


Leu Gly Gly Val Ile Ala Ala Arg Ile Ser Val 
        115                 120             


<210>  99
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  99
atgctgccga gagtgggctg ccccgcgctg ccgctgccgc cgccgccgct gctgccgctg       60

ctgccgctgc tgctgctgct actgggcgcg agtggcggcg gcggcggggc gcgcgcggag      120

gtgctgttcc gctgcccgcc ctgcacaccc gagcgcctgg ccgcctgcgg gcccccgccg      180

gttgcgccgc ccgccgcggt ggccgcagtg gccggaggcg cccgcatgcc atgcgcggag      240

ctcgtccggg agccgggctg cggctgctgc tcggtgtgcg cccggctgga gggcgaggcg      300

tgcggcgtct acaccccgcg ctgcggccag gggctgcgct gctatcccca cccgggctcc      360

gagctgcccc tgcaggcgct ggtcatgggc gagggcactt gtgagaagcg ccgggacgcc      420

gagtatggcg ccagcccgga gcaggttgca gacaatggcg atgaccactc agaaggaggc      480

ctggtggaga accacgtgga cagcaccatg aacatgttgg gcgggggagg cagtgctggc      540

cggaagcccc tcaagtcggg tatgaaggag ctggccgtgt tccgggagaa ggtcactgag      600

cagcaccggc agatgggcaa gggtggcaag catcaccttg gcctggagga gcccaagaag      660

ctgcgaccac cccctgccag gactccctgc caacaggaac tggaccaggt cctggagcgg      720

atctccacca tgcgccttcc ggatgagcgg ggccctctgg agcacctcta ctccctgcac      780

atccccaact gtgacaagca tggcctgtac aacctcaaac agtgcaagat gtctctgaac      840

gggcagcgtg gggagtgctg gtgtgtgaac cccaacaccg ggaagctgat ccagggagcc      900

cccaccatcc ggggggaccc cgagtgtcat ctcttctaca atgagcagca ggaggctcgc      960

ggggtgcaca cccagcggat gcagtag                                          987


<210>  100
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  101
<211>  2781
<212>  DNA
<213>  Homo sapiens

<400>  101
atgagtcggc gaaggaaaca tgatgacagc cctagcccga agaaaacgcc gcacaaaaca       60

gtggcggcgg aggaatgcgg ctcggtggtc gagccaggga ggaggcggct gagatcggcc      120

cgcggttcgt ggccctgcgg ggctagagag gggcctcccg ggccagtgcg gcagcgagag      180

cagcctccga ccgccgccct gtgcagtaaa agtaaccccg aggaaaggta tgaaacacca      240

aagagagcgc tgaaaatgga ctcactgtca tcttccttca gttctcctaa tgatccagat      300

ggacagaatg atatcttttg ggatcagaat tctccattga caaagcagtt aggtaaagga      360

agaaaaaaac agatttacac cacagatagt gatgagattt cacatattgt taatcgtatt      420

gctcctcagg atgaaaaacc aacaacaaat tctatgctgg acatgtggat tggtgaaact      480

gctattcctt gtactcccag tgtagcaaaa ggaaaatcaa gagcaaaaat cagctgcaca      540

aagttaaaaa cacaaagtca agaagaagaa cttatgaaac tggctaaaca atttgataaa      600

aatatggaag agctagatgt gattcaagag caaaacaaga ggaattatga ttttacccag      660

atgatttcag aaacagagat tttaagtaat tataaagata atatacagat gtggtcatta      720

cataatatag ttcccgaaat agataatgct acaaaaaagc caatcaaagg aaacaccaag      780

atatctgtgg caaataatca aaatagcagt cagaagccat ttgaccaaat tgctgaagca      840

gcctttaatg ctatttttga tggttctact cagaaatgta gcggacagtt aagccaagaa      900

ctgccagagg ctttttggag caccagtaat actacctttg taaagacaaa tgctttgaaa      960

gaggagaaaa tcattactaa tgaaactctg gtcattgaaa aactgtcaaa taaaacccca     1020

cgatcacttt cttctcaagt agatacaccc ataatgacaa aatcatgtgt gacttcctgt     1080

actaaggagc cagaaacttc taataagtac attgatgcat ttactacaag tgattttgag     1140

gatgattggg aaaacttact aggtagtgaa ccttttgcta tgcaaaatat cgacatgcct     1200

gaactctttc cttctaaaac agcccatgtt actgatcaaa aggaaatttg tacctttaat     1260

agtaaaactg ttaaaaatac gtcaagagca aatacaagtc cagatgccag gttaggagat     1320

tcaaaagtat tacaagatct ttcttcaaag acatatgaca gagaattaat agatgcagaa     1380

tatagatttt caccaaattc aaataaatca aacaaattat ccactggaaa taaaatgaaa     1440

tttgagaact cttccaataa aattgttatt caagacgaaa ttcaaaattg tatagttaca     1500

tctaatctga caaaaataaa ggaagatatt cttactaact ctactgaagc ttctgaaagg     1560

aagtcagctt tgaacacaag gtattctaat gaacagaaaa ataagtgcat tttaaatcag     1620

tctattaaag cccctgttaa tactgatctt tttggctctg caaatctagg cagtaaaacc     1680

agtgttagta acccaaatca gactagtgca tcaaaagtag gttctttctt tgatgattgg     1740

aatgatccct catttgccaa tgaaattatt aaagcatgtc atcaattaga taatacctgg     1800

gaagcagatg atgtagatga tgatttgttg taccaagcat gtgatgatat tgaaagacta     1860

actcagcaac aagacattag aaaggacagt aagacatcag aaagtatatg tgagatcaat     1920

aataattccg aacatggagc caaactaact cagcaacaag acattagaaa ggacagtaag     1980

acatcagaaa gtatatgtga gatcaataat aattccgaac atggagccaa aaacatgttt     2040

gctatatcta aacaaggaag taatttggta caatcaaagc atttgaatcc aggcagcatt     2100

tcagtgcaga catctttgac aaatagctca caaatagata agccaatgaa gatggagaaa     2160

ggggaaatgt atggaaattc tccaagattt ttaggtgcca caaatttgac tatgtattct     2220

aagatctcaa actgtcagat aaataatctg catgtgtctt atactaacac tgatgttcca     2280

atacaagtga atagttccaa attggttctt ccaggaagtt caagtttgaa tgtaacttca     2340

gatcatatga atacagaaat tactacttat aagaagaaat tgagtactaa tcagccatgc     2400

cataagactg taacagatga agctcagagc aaccttaaca caacagttgg attttcaaag     2460

tttacattta caaggatgaa aaattctcag attctttctc agtttaatca aaattgtata     2520

actggaagta tgtctgatac caaaattaca cagggtgtgg agaaaaagaa aggtgtcaac     2580

ccattactgg aggaagctgt tggacagcaa tctttggtga aactttctga atctttgaaa     2640

caatcttcaa aagaggaaga agagaaaaat agaaagtgtt ctcctgaaga aattcagaga     2700

aaaagacaag aagcactggt tcggagaatg gctaaagcac gagcctcatc tgtaaatgca     2760

gctcccactt catttcttta a                                               2781


<210>  102
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Arg Arg Arg Lys His Asp Asp Ser Pro Ser Pro Lys Lys Thr 
1               5                   10                  15      


Pro His Lys Thr Val Ala Ala Glu Glu Cys Gly Ser Val Val Glu Pro 
            20                  25                  30          


Gly Arg Arg Arg Leu Arg Ser Ala Arg Gly Ser Trp Pro Cys Gly Ala 
        35                  40                  45              


Arg Glu Gly Pro Pro Gly Pro Val Arg Gln Arg Glu Gln Pro Pro Thr 
    50                  55                  60                  


Ala Ala Leu Cys Ser Lys Ser Asn Pro Glu Glu Arg Tyr Glu Thr Pro 
65                  70                  75                  80  


Lys Arg Ala Leu Lys Met Asp Ser Leu Ser Ser Ser Phe Ser Ser Pro 
                85                  90                  95      


Asn Asp Pro Asp Gly Gln Asn Asp Ile Phe Trp Asp Gln Asn Ser Pro 
            100                 105                 110         


Leu Thr Lys Gln Leu Gly Lys Gly Arg Lys Lys Gln Ile Tyr Thr Thr 
        115                 120                 125             


Asp Ser Asp Glu Ile Ser His Ile Val Asn Arg Ile Ala Pro Gln Asp 
    130                 135                 140                 


Glu Lys Pro Thr Thr Asn Ser Met Leu Asp Met Trp Ile Gly Glu Thr 
145                 150                 155                 160 


Ala Ile Pro Cys Thr Pro Ser Val Ala Lys Gly Lys Ser Arg Ala Lys 
                165                 170                 175     


Ile Ser Cys Thr Lys Leu Lys Thr Gln Ser Gln Glu Glu Glu Leu Met 
            180                 185                 190         


Lys Leu Ala Lys Gln Phe Asp Lys Asn Met Glu Glu Leu Asp Val Ile 
        195                 200                 205             


Gln Glu Gln Asn Lys Arg Asn Tyr Asp Phe Thr Gln Met Ile Ser Glu 
    210                 215                 220                 


Thr Glu Ile Leu Ser Asn Tyr Lys Asp Asn Ile Gln Met Trp Ser Leu 
225                 230                 235                 240 


His Asn Ile Val Pro Glu Ile Asp Asn Ala Thr Lys Lys Pro Ile Lys 
                245                 250                 255     


Gly Asn Thr Lys Ile Ser Val Ala Asn Asn Gln Asn Ser Ser Gln Lys 
            260                 265                 270         


Pro Phe Asp Gln Ile Ala Glu Ala Ala Phe Asn Ala Ile Phe Asp Gly 
        275                 280                 285             


Ser Thr Gln Lys Cys Ser Gly Gln Leu Ser Gln Glu Leu Pro Glu Ala 
    290                 295                 300                 


Phe Trp Ser Thr Ser Asn Thr Thr Phe Val Lys Thr Asn Ala Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ile Ile Thr Asn Glu Thr Leu Val Ile Glu Lys Leu Ser 
                325                 330                 335     


Asn Lys Thr Pro Arg Ser Leu Ser Ser Gln Val Asp Thr Pro Ile Met 
            340                 345                 350         


Thr Lys Ser Cys Val Thr Ser Cys Thr Lys Glu Pro Glu Thr Ser Asn 
        355                 360                 365             


Lys Tyr Ile Asp Ala Phe Thr Thr Ser Asp Phe Glu Asp Asp Trp Glu 
    370                 375                 380                 


Asn Leu Leu Gly Ser Glu Pro Phe Ala Met Gln Asn Ile Asp Met Pro 
385                 390                 395                 400 


Glu Leu Phe Pro Ser Lys Thr Ala His Val Thr Asp Gln Lys Glu Ile 
                405                 410                 415     


Cys Thr Phe Asn Ser Lys Thr Val Lys Asn Thr Ser Arg Ala Asn Thr 
            420                 425                 430         


Ser Pro Asp Ala Arg Leu Gly Asp Ser Lys Val Leu Gln Asp Leu Ser 
        435                 440                 445             


Ser Lys Thr Tyr Asp Arg Glu Leu Ile Asp Ala Glu Tyr Arg Phe Ser 
    450                 455                 460                 


Pro Asn Ser Asn Lys Ser Asn Lys Leu Ser Thr Gly Asn Lys Met Lys 
465                 470                 475                 480 


Phe Glu Asn Ser Ser Asn Lys Ile Val Ile Gln Asp Glu Ile Gln Asn 
                485                 490                 495     


Cys Ile Val Thr Ser Asn Leu Thr Lys Ile Lys Glu Asp Ile Leu Thr 
            500                 505                 510         


Asn Ser Thr Glu Ala Ser Glu Arg Lys Ser Ala Leu Asn Thr Arg Tyr 
        515                 520                 525             


Ser Asn Glu Gln Lys Asn Lys Cys Ile Leu Asn Gln Ser Ile Lys Ala 
    530                 535                 540                 


Pro Val Asn Thr Asp Leu Phe Gly Ser Ala Asn Leu Gly Ser Lys Thr 
545                 550                 555                 560 


Ser Val Ser Asn Pro Asn Gln Thr Ser Ala Ser Lys Val Gly Ser Phe 
                565                 570                 575     


Phe Asp Asp Trp Asn Asp Pro Ser Phe Ala Asn Glu Ile Ile Lys Ala 
            580                 585                 590         


Cys His Gln Leu Asp Asn Thr Trp Glu Ala Asp Asp Val Asp Asp Asp 
        595                 600                 605             


Leu Leu Tyr Gln Ala Cys Asp Asp Ile Glu Arg Leu Thr Gln Gln Gln 
    610                 615                 620                 


Asp Ile Arg Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn 
625                 630                 635                 640 


Asn Asn Ser Glu His Gly Ala Lys Leu Thr Gln Gln Gln Asp Ile Arg 
                645                 650                 655     


Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn Asn Asn Ser 
            660                 665                 670         


Glu His Gly Ala Lys Asn Met Phe Ala Ile Ser Lys Gln Gly Ser Asn 
        675                 680                 685             


Leu Val Gln Ser Lys His Leu Asn Pro Gly Ser Ile Ser Val Gln Thr 
    690                 695                 700                 


Ser Leu Thr Asn Ser Ser Gln Ile Asp Lys Pro Met Lys Met Glu Lys 
705                 710                 715                 720 


Gly Glu Met Tyr Gly Asn Ser Pro Arg Phe Leu Gly Ala Thr Asn Leu 
                725                 730                 735     


Thr Met Tyr Ser Lys Ile Ser Asn Cys Gln Ile Asn Asn Leu His Val 
            740                 745                 750         


Ser Tyr Thr Asn Thr Asp Val Pro Ile Gln Val Asn Ser Ser Lys Leu 
        755                 760                 765             


Val Leu Pro Gly Ser Ser Ser Leu Asn Val Thr Ser Asp His Met Asn 
    770                 775                 780                 


Thr Glu Ile Thr Thr Tyr Lys Lys Lys Leu Ser Thr Asn Gln Pro Cys 
785                 790                 795                 800 


His Lys Thr Val Thr Asp Glu Ala Gln Ser Asn Leu Asn Thr Thr Val 
                805                 810                 815     


Gly Phe Ser Lys Phe Thr Phe Thr Arg Met Lys Asn Ser Gln Ile Leu 
            820                 825                 830         


Ser Gln Phe Asn Gln Asn Cys Ile Thr Gly Ser Met Ser Asp Thr Lys 
        835                 840                 845             


Ile Thr Gln Gly Val Glu Lys Lys Lys Gly Val Asn Pro Leu Leu Glu 
    850                 855                 860                 


Glu Ala Val Gly Gln Gln Ser Leu Val Lys Leu Ser Glu Ser Leu Lys 
865                 870                 875                 880 


Gln Ser Ser Lys Glu Glu Glu Glu Lys Asn Arg Lys Cys Ser Pro Glu 
                885                 890                 895     


Glu Ile Gln Arg Lys Arg Gln Glu Ala Leu Val Arg Arg Met Ala Lys 
            900                 905                 910         


Ala Arg Ala Ser Ser Val Asn Ala Ala Pro Thr Ser Phe Leu 
        915                 920                 925     


<210>  103
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  103
atgcctctcc tcctcttgct gctcctgctg ccaagcccct tacaccccca ccccatctgt       60

gaggtctcca aagtggccag ccacctagaa gtgaactgtg acaagaggaa tctgacagcg      120

ctgcctccag acctgccgaa agacacaacc atcctccacc tgagtgagaa cctcctgtac      180

accttctccc tggcaaccct gatgccttac actcgcctca ctcagctgaa cctagatagg      240

tgcgagctca ccaagctcca ggtcgatggg acgctgccag tgctggggac cctggatcta      300

tcccacaatc agctgcaaag cctgcccttg ctagggcaga cactgcctgc tctcaccgtc      360

ctggacgtct ccttcaaccg gctgacctcg ctgcctcttg gtgccctgcg tggtcttggc      420

gaactccaag agctctacct gaaaggcaat gagctgaaga ccctgccccc agggctcctg      480

acgcccacac ccaagctgga gaagctcagt ctggctaaca acaacttgac tgagctcccc      540

gctgggctcc tgaatgggct ggagaatctc gacacccttc tcctccaaga gaactcgctg      600

tatacaatac caaagggctt ttttgggtcc cacctcctgc cttttgcttt tctccacggg      660

aacccctggt tatgcaactg tgagatcctc tattttcgtc gctggctgca ggacaatgct      720

gaaaatgtct acgtatggaa gcaaggtgtg gacgtcaagg ccatgacctc taacgtggcc      780

agtgtgcagt gtgacaattc agacaagttt cccgtctaca aatacccagg aaaggggtgc      840

cccacccttg gtgatgaagg tgacacagac ctatatgatt actacccaga agaggacact      900

gagggcgata aggtgcgtgc cacaaggact gtggtcaagt tccccaccaa agcccataca      960

accccctggg gtctattcta ctcatggtcc actgcttctc tagacagcca aatgccctcc     1020

tccttgcatc caacacaaga atccactaag gagcagacca cattcccacc tagatggacc     1080

ccaaatttca cacttcacat ggaatccatc acattctcca aaactccaaa atccactact     1140

gaaccaaccc caagcccgac cacctcagag cccgtcccgg agcccgcccc aaacatgacc     1200

accctggagc ccactccaag cccgaccacc ccagagccca cctcagagcc cgcccccagc     1260

ccgaccaccc cggagcccac ctcagagccc gcccccagcc cgaccacccc ggagcccacc     1320

ccaatcccga ccatcgccac aagcccgacc atcctggtgt ctgccacaag cctgatcact     1380

ccaaaaagca catttttaac taccacaaaa cccgtatcac tcttagaatc caccaaaaaa     1440

accatccctg aacttgatca gccaccaaag ctccgtgggg tgctccaagg gcatttggag     1500

agctccagaa atgacccttt tctccacccc gacttttgct gcctcctccc cctgggcttc     1560

tatgtcttgg gtctcttctg gctgctcttt gcctctgtgg tcctcatcct gctgctgagc     1620

tgggttgggc atgtgaaacc acaggccctg gactctggcc aaggtgctgc tctgaccaca     1680

gccacacaaa ccacacacct ggagctgcag aggggacggc aagtgacagt gccccgggcc     1740

tggctgctct tccttcgagg ttcgcttccc actttccgct ccagcctctt cctgtgggta     1800

cggcctaatg gccgtgtggg gcctctagtg gcaggaagga ggccctcagc tctgagtcag     1860

ggtcgtggtc aggacctgct gagcacagtg agcattaggt actctggcca cagcctctga     1920


<210>  104
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro 
1               5                   10                  15      


His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
            20                  25                  30          


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
        35                  40                  45              


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
    50                  55                  60                  


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
65                  70                  75                  80  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
                85                  90                  95      


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
            100                 105                 110         


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
        115                 120                 125             


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
145                 150                 155                 160 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
                165                 170                 175     


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
            180                 185                 190         


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
        195                 200                 205             


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
    210                 215                 220                 


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
225                 230                 235                 240 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
                245                 250                 255     


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
            260                 265                 270         


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
        275                 280                 285             


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
    290                 295                 300                 


Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr 
305                 310                 315                 320 


Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser 
                325                 330                 335     


Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln 
            340                 345                 350         


Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu 
        355                 360                 365             


Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro 
    370                 375                 380                 


Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr 
385                 390                 395                 400 


Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu 
                405                 410                 415     


Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile 
            420                 425                 430         


Ala Thr Ser Pro Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro 
        435                 440                 445             


Lys Ser Thr Phe Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser 
    450                 455                 460                 


Thr Lys Lys Thr Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly 
465                 470                 475                 480 


Val Leu Gln Gly His Leu Glu Ser Ser Arg Asn Asp Pro Phe Leu His 
                485                 490                 495     


Pro Asp Phe Cys Cys Leu Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu 
            500                 505                 510         


Phe Trp Leu Leu Phe Ala Ser Val Val Leu Ile Leu Leu Leu Ser Trp 
        515                 520                 525             


Val Gly His Val Lys Pro Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala 
    530                 535                 540                 


Leu Thr Thr Ala Thr Gln Thr Thr His Leu Glu Leu Gln Arg Gly Arg 
545                 550                 555                 560 


Gln Val Thr Val Pro Arg Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu 
                565                 570                 575     


Pro Thr Phe Arg Ser Ser Leu Phe Leu Trp Val Arg Pro Asn Gly Arg 
            580                 585                 590         


Val Gly Pro Leu Val Ala Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly 
        595                 600                 605             


Arg Gly Gln Asp Leu Leu Ser Thr Val Ser Ile Arg Tyr Ser Gly His 
    610                 615                 620                 


Ser Leu 
625     


<210>  105
<211>  2496
<212>  DNA
<213>  Homo sapiens

<400>  105
atgggggagc ttttccggag tgaagaaatg acactggccc agctttttct acagtcagag       60

gctgcttatt gttgtgtcag tgaattagga gaacttggaa aggttcagtt tcgtgactta      120

aatccagatg tgaatgtttt ccaacggaaa tttgtgaatg aagttagaag atgtgaagaa      180

atggatcgaa agcttcgatt tgttgagaaa gagataagaa aagctaacat tccgattatg      240

gacaccggtg aaaacccaga ggttcccttc ccccgggaca tgattgactt agaggccaat      300

tttgagaaga ttgaaaatga actgaaggaa atcaacacaa accaggaagc tctgaagaga      360

aacttcctgg aactgaccga attaaaattt atacttcgca aaactcagca attttttgat      420

gagatggcgg atccagactt gttggaagag tcctcatccc tcttggagcc aagtgagatg      480

ggaagaggca ctcctttaag acttggcttc gtggctggtg tcattaaccg ggagcgcatc      540

cctacttttg agcgcatgct ttggcgggta tgccggggaa atgtgttcct gcgacaggct      600

gaaatcgaga accccctgga ggatcctgtg actggcgact acgtgcacaa gtctgtgttt      660

atcattttct tccaaggcga tcagctgaaa aacagagtca agaaaatctg tgaagggttc      720

cgagcctcac tctatccctg tcctgagaca ccacaggaga ggaaggaaat ggcttctgga      780

gtgaatacca ggattgatga tctccaaatg gttctgaatc aaacggagga tcaccgccag      840

agggttctgc aggcagctgc taagaacatc cgtgtctggt tcatcaaagt gcggaagatg      900

aaggccatct atcacaccct gaacctgtgc aacatagatg tgactcagaa atgcttgatt      960

gcagaggtct ggtgccctgt caccgacctt gactccatcc agtttgcact cagaaggggc     1020

acggaacaca gtggttccac tgtaccttcc attttgaaca ggatgcagac aaaccagact     1080

cccccaacct ataacaaaac caacaagttt acctatggct ttcagaacat agtagatgct     1140

tatggaattg gaacttaccg agagataaat ccagctccgt atactattat cacgttccct     1200

tttctatttg ctgtgatgtt tggagacttc ggtcatggca ttttaatgac cctttttgct     1260

gtgtggatgg tactgaggga gagccggatc ctttcccaga agaatgagaa tgagatgttt     1320

agcactgtgt tcagtggtcg atacattatt ttattgatgg gtgtgttctc catgtacact     1380

ggcctcatct acaatgattg cttttccaag tctcttaata tctttgggtc atcctggagt     1440

gtacggccga tgtttactta taattggact gaagagacgc ttcgggggaa ccctgttcta     1500

cagctgaacc cagccctccc tggagtgttt ggtggaccat acccttttgg cattgatcca     1560

atttggaaca ttgctaccaa taaactgacg ttcttgaact cctttaagat gaagatgtct     1620

gttatccttg gtatcatcca tatgctgttt ggagtcagcc tgagtctgtt caaccatatc     1680

tatttcaaga agcccctgaa tatctacttt ggatttattc ctgaaataat cttcatgacc     1740

tctttgtttg gctatttggt tatccttatt ttttacaagt ggacggccta tgatgctcat     1800

acctctgaga atgcaccaag ccttctgatc catttcataa acatgttcct cttttcctac     1860

ccagagtctg gttattcaat gttgtattct ggacagaaag gaattcagtg tttcctggta     1920

gtggttgcac tactgtgtgt accttggatg ctgctgttta aaccattggt ccttcgccgt     1980

cagtatttga ggagaaagca tttgggaact ctcaactttg gtgggatcag ggtgggcaac     2040

ggaccgacag aggaggatgc tgagattatt cagcatgacc agctctccac ccactcagag     2100

gacgcagacg agtttgactt tggggacacc atggtccacc aggccatcca caccatcgag     2160

tactgcctgg gctgcatctc caacactgcc tcctacttgc ggctctgggc cctcagcctc     2220

gctcatgcgc agctgtctga ggtgctttgg accatggtga tccacatcgg cctgagcgtg     2280

aagagcttgg cgggaggttt ggtgctgttc ttcttcttca ctgcctttgc caccctgacc     2340

gtggccatcc tcctgatcat ggagggcctc tcggcctttc tccacgcact gcgcttacac     2400

tgggttgagt tccagaataa attctacagc gggaccggtt tcaagttctt acccttctcc     2460

ttcgagcata ttcgggaagg gaagtttgaa gagtga                               2496


<210>  106
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Gly Glu Leu Phe Arg Ser Glu Glu Met Thr Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Thr Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Thr Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Thr Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Thr Gln Gln Phe Phe Asp Glu Met Ala Asp 
    130                 135                 140                 


Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met 
145                 150                 155                 160 


Gly Arg Gly Thr Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn 
                165                 170                 175     


Arg Glu Arg Ile Pro Thr Phe Glu Arg Met Leu Trp Arg Val Cys Arg 
            180                 185                 190         


Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp 
        195                 200                 205             


Pro Val Thr Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe 
    210                 215                 220                 


Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe 
225                 230                 235                 240 


Arg Ala Ser Leu Tyr Pro Cys Pro Glu Thr Pro Gln Glu Arg Lys Glu 
                245                 250                 255     


Met Ala Ser Gly Val Asn Thr Arg Ile Asp Asp Leu Gln Met Val Leu 
            260                 265                 270         


Asn Gln Thr Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys 
        275                 280                 285             


Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr 
    290                 295                 300                 


His Thr Leu Asn Leu Cys Asn Ile Asp Val Thr Gln Lys Cys Leu Ile 
305                 310                 315                 320 


Ala Glu Val Trp Cys Pro Val Thr Asp Leu Asp Ser Ile Gln Phe Ala 
                325                 330                 335     


Leu Arg Arg Gly Thr Glu His Ser Gly Ser Thr Val Pro Ser Ile Leu 
            340                 345                 350         


Asn Arg Met Gln Thr Asn Gln Thr Pro Pro Thr Tyr Asn Lys Thr Asn 
        355                 360                 365             


Lys Phe Thr Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly 
    370                 375                 380                 


Thr Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro 
385                 390                 395                 400 


Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met 
                405                 410                 415     


Thr Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser 
            420                 425                 430         


Gln Lys Asn Glu Asn Glu Met Phe Ser Thr Val Phe Ser Gly Arg Tyr 
        435                 440                 445             


Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Thr Gly Leu Ile Tyr 
    450                 455                 460                 


Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser 
465                 470                 475                 480 


Val Arg Pro Met Phe Thr Tyr Asn Trp Thr Glu Glu Thr Leu Arg Gly 
                485                 490                 495     


Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly 
            500                 505                 510         


Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Thr Asn Lys 
        515                 520                 525             


Leu Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly 
    530                 535                 540                 


Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile 
545                 550                 555                 560 


Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile 
                565                 570                 575     


Ile Phe Met Thr Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr 
            580                 585                 590         


Lys Trp Thr Ala Tyr Asp Ala His Thr Ser Glu Asn Ala Pro Ser Leu 
        595                 600                 605             


Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly 
    610                 615                 620                 


Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val 
625                 630                 635                 640 


Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu 
                645                 650                 655     


Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Thr Leu Asn 
            660                 665                 670         


Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Thr Glu Glu Asp Ala Glu 
        675                 680                 685             


Ile Ile Gln His Asp Gln Leu Ser Thr His Ser Glu Asp Ala Asp Glu 
    690                 695                 700                 


Phe Asp Phe Gly Asp Thr Met Val His Gln Ala Ile His Thr Ile Glu 
705                 710                 715                 720 


Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp 
                725                 730                 735     


Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp Thr Met 
            740                 745                 750         


Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val 
        755                 760                 765             


Leu Phe Phe Phe Phe Thr Ala Phe Ala Thr Leu Thr Val Ala Ile Leu 
    770                 775                 780                 


Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His 
785                 790                 795                 800 


Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr Gly Phe Lys Phe 
                805                 810                 815     


Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys Phe Glu Glu 
            820                 825                 830     


<210>  107
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  107
atgaagtcca gcggcctctt ccccttcctg gtgctgcttg ccctgggaac tctggcacct       60

tgggctgtgg aaggctctgg aaagtccttc aaagctggag tctgtcctcc taagaaatct      120

gcccagtgcc ttagatacaa gaaacctgag tgccagagtg actggcagtg tccagggaag      180

aagagatgtt gtcctgacac ttgtggcatc aaatgcctgg atcctgttga caccccaaac      240

ccaacaagga ggaagcctgg gaagtgccca gtgacttatg gccaatgttt gatgcttaac      300

ccccccaatt tctgtgagat ggatggccag tgcaagcgtg acttgaagtg ttgcatgggc      360

atgtgtggga aatcctgcgt ttcccctgtg aaagcttga                             399


<210>  108
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Lys Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly 
1               5                   10                  15      


Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala 
            20                  25                  30          


Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys Lys 
        35                  40                  45              


Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg Cys Cys 
    50                  55                  60                  


Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp Thr Pro Asn 
65                  70                  75                  80  


Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val Thr Tyr Gly Gln Cys 
                85                  90                  95      


Leu Met Leu Asn Pro Pro Asn Phe Cys Glu Met Asp Gly Gln Cys Lys 
            100                 105                 110         


Arg Asp Leu Lys Cys Cys Met Gly Met Cys Gly Lys Ser Cys Val Ser 
        115                 120                 125             


Pro Val Lys Ala 
    130         


<210>  109
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  109
atgactagca aacaagcaat gtcatctaac gaacaagaaa ggctcttgtg ttataatggg       60

gaagtccttg ttttccagtt gtctaaagga aattttgcag ataaagagcc tacaaaaaca      120

cccatattac atgtcagaag aatggtattt gacagaggaa caaaagtatt tgttcagaag      180

tccactggat tttttaccat aaaggaagaa aactctcatt taaaaatcat gtgttgcaac      240

tgtgtgtcag atttcagaac tggaattaac ctcccttaca ttgtgataga aaaaaataaa      300

aagaataatg tttttgaata ttttttacta atccttcaca gtactaataa atttgaaatg      360

cgtttgagtt ttaaactagg ctatgagatg aaggatggcc taagggtcct taatggccct      420

ttaattttat ggaggcatgt caaagcattc ttctttatct cttctcaaac tggcaaagtt      480

gttagtgtgt caggtaactt ttcctctatt cagtgggcag gggagattga aaatttaggt      540

atggttttat tgggactaaa ggaatgttgt ttatctgagg aagaatgtac tcaagagcct      600

tcaaaatcag attatgcaat ttggaatacc aaattttgtg tatattctct tgaaagtcaa      660

gaagtattaa gtgatatata cattattcct cctgcttaca gcagtgtggt gacttatgta      720

catatttgtg caactgagat catcaaaaac cagttaagaa tatctctcat tgcccttact      780

cgaaagaatc agctgatttc atttcagaat ggaactccta aaaatgtgtg ccagcttcca      840

tttggagatc cttgtgcagt tcaacttatg gattcaggtg gaggaaacct ctttttcgtt      900

gtatccttta tatccaataa tgcttgtgct gtatggaaag agagctttca ggttgctgct      960

aaatgggaaa aacttagctt agtactgata gatgacttta ttggaagtgg aactgaacaa     1020

gtactcctac tttttaagga ctccttgaac tcagactgcc tgacttcatt taaaataacg     1080

gatcttggaa aaataaacta ttcgagtgaa ccatcagatt gcaatgaaga tgacttattt     1140

gaagacaaac aagagaatcg ttacctggtg gttccacctc tagaaacagg actgaaagtt     1200

tgtttttctt cttttcggga attacggcag catctgttgc ttaaggaaaa aattatttca     1260

aaatcttaca aagctttaat aaacctagtt caaggaaaag atgataatac gtcaagtgca     1320

gaggagaagg aatgtcttgt tcctctttgt ggtgaagaag aaaattctgt ccatatctta     1380

gatgaaaagt tatcagacaa ttttcaagat tcagaacagc tagtagagaa gatatggtat     1440

cgtgtaatag atgatagctt ggttgttgga gtgaaaacta catcttcttt gaagctgtcc     1500

ctgaatgatg tgactttatc attgttaatg gatcaagccc atgactccag atttcggctt     1560

ctaaagtgtc aaaatagggt gattaagttg agtacaaatc ctttcccagc accatacttg     1620

atgccatgtg aaataggatt ggaagcaaaa agggtcacgt tgacccctga tagcaagaaa     1680

gaggaaagct ttgtttgtga acacccatct aagaaagagt gtgtacagat aattactgct     1740

gtaacatctc tttcaccact tttaacattc agtaaatttt gttgcactgt actgctacaa     1800

attatggaga gagaaagtgg taactgtcct aaagatcgtt atgttgtgtg tggcagagtt     1860

tttttaagtc tagaagatct ttcaactggg aagtacctac tgacatttcc aaagaagaaa     1920

cctatagagc acatggaaga tctttttgca cttcttgcag cattccataa atcttgtttt     1980

caaatcacat cacccggcta tgccctgaat tcaatgaagg tgtggctctt agaacatatg     2040

aaatgtgaaa taatcaaaga atttccagaa gtgtactttt gtgaaagacc gggaagtttc     2100

tatgggacac tcttcacttg gaaacagaga acaccattcg aagggatttt aataatctat     2160

tccaggaatc aaacagttat gttccagtgc cttcataatc tcatcagaat tctccctata     2220

aactgtttcc tcaaaaatct aaaatcagga agtgagaatt tcctaattga taatatggca     2280

tttactttgg agaaggaact agtcaccctt agttctcttt cttctgccat agctaaacat     2340

gaaagcaatt ttatgcagag gtgtgaagtg agcaaaggaa agagtagtgt cgtcgcggct     2400

gctttatcag acagaaggga aaatatccat ccctacagaa aagaacttca gagagaaaag     2460

aagaaaatgt tgcaaacgaa cctaaaagtg agtggtgccc tttacagaga aataactttg     2520

aaagtagctg aggttcagtt gaaatcagac tttgctgcac agaaactgag taatttataa     2580


<210>  110
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Thr Ser Lys Gln Ala Met Ser Ser Asn Glu Gln Glu Arg Leu Leu 
1               5                   10                  15      


Cys Tyr Asn Gly Glu Val Leu Val Phe Gln Leu Ser Lys Gly Asn Phe 
            20                  25                  30          


Ala Asp Lys Glu Pro Thr Lys Thr Pro Ile Leu His Val Arg Arg Met 
        35                  40                  45              


Val Phe Asp Arg Gly Thr Lys Val Phe Val Gln Lys Ser Thr Gly Phe 
    50                  55                  60                  


Phe Thr Ile Lys Glu Glu Asn Ser His Leu Lys Ile Met Cys Cys Asn 
65                  70                  75                  80  


Cys Val Ser Asp Phe Arg Thr Gly Ile Asn Leu Pro Tyr Ile Val Ile 
                85                  90                  95      


Glu Lys Asn Lys Lys Asn Asn Val Phe Glu Tyr Phe Leu Leu Ile Leu 
            100                 105                 110         


His Ser Thr Asn Lys Phe Glu Met Arg Leu Ser Phe Lys Leu Gly Tyr 
        115                 120                 125             


Glu Met Lys Asp Gly Leu Arg Val Leu Asn Gly Pro Leu Ile Leu Trp 
    130                 135                 140                 


Arg His Val Lys Ala Phe Phe Phe Ile Ser Ser Gln Thr Gly Lys Val 
145                 150                 155                 160 


Val Ser Val Ser Gly Asn Phe Ser Ser Ile Gln Trp Ala Gly Glu Ile 
                165                 170                 175     


Glu Asn Leu Gly Met Val Leu Leu Gly Leu Lys Glu Cys Cys Leu Ser 
            180                 185                 190         


Glu Glu Glu Cys Thr Gln Glu Pro Ser Lys Ser Asp Tyr Ala Ile Trp 
        195                 200                 205             


Asn Thr Lys Phe Cys Val Tyr Ser Leu Glu Ser Gln Glu Val Leu Ser 
    210                 215                 220                 


Asp Ile Tyr Ile Ile Pro Pro Ala Tyr Ser Ser Val Val Thr Tyr Val 
225                 230                 235                 240 


His Ile Cys Ala Thr Glu Ile Ile Lys Asn Gln Leu Arg Ile Ser Leu 
                245                 250                 255     


Ile Ala Leu Thr Arg Lys Asn Gln Leu Ile Ser Phe Gln Asn Gly Thr 
            260                 265                 270         


Pro Lys Asn Val Cys Gln Leu Pro Phe Gly Asp Pro Cys Ala Val Gln 
        275                 280                 285             


Leu Met Asp Ser Gly Gly Gly Asn Leu Phe Phe Val Val Ser Phe Ile 
    290                 295                 300                 


Ser Asn Asn Ala Cys Ala Val Trp Lys Glu Ser Phe Gln Val Ala Ala 
305                 310                 315                 320 


Lys Trp Glu Lys Leu Ser Leu Val Leu Ile Asp Asp Phe Ile Gly Ser 
                325                 330                 335     


Gly Thr Glu Gln Val Leu Leu Leu Phe Lys Asp Ser Leu Asn Ser Asp 
            340                 345                 350         


Cys Leu Thr Ser Phe Lys Ile Thr Asp Leu Gly Lys Ile Asn Tyr Ser 
        355                 360                 365             


Ser Glu Pro Ser Asp Cys Asn Glu Asp Asp Leu Phe Glu Asp Lys Gln 
    370                 375                 380                 


Glu Asn Arg Tyr Leu Val Val Pro Pro Leu Glu Thr Gly Leu Lys Val 
385                 390                 395                 400 


Cys Phe Ser Ser Phe Arg Glu Leu Arg Gln His Leu Leu Leu Lys Glu 
                405                 410                 415     


Lys Ile Ile Ser Lys Ser Tyr Lys Ala Leu Ile Asn Leu Val Gln Gly 
            420                 425                 430         


Lys Asp Asp Asn Thr Ser Ser Ala Glu Glu Lys Glu Cys Leu Val Pro 
        435                 440                 445             


Leu Cys Gly Glu Glu Glu Asn Ser Val His Ile Leu Asp Glu Lys Leu 
    450                 455                 460                 


Ser Asp Asn Phe Gln Asp Ser Glu Gln Leu Val Glu Lys Ile Trp Tyr 
465                 470                 475                 480 


Arg Val Ile Asp Asp Ser Leu Val Val Gly Val Lys Thr Thr Ser Ser 
                485                 490                 495     


Leu Lys Leu Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Met Asp Gln 
            500                 505                 510         


Ala His Asp Ser Arg Phe Arg Leu Leu Lys Cys Gln Asn Arg Val Ile 
        515                 520                 525             


Lys Leu Ser Thr Asn Pro Phe Pro Ala Pro Tyr Leu Met Pro Cys Glu 
    530                 535                 540                 


Ile Gly Leu Glu Ala Lys Arg Val Thr Leu Thr Pro Asp Ser Lys Lys 
545                 550                 555                 560 


Glu Glu Ser Phe Val Cys Glu His Pro Ser Lys Lys Glu Cys Val Gln 
                565                 570                 575     


Ile Ile Thr Ala Val Thr Ser Leu Ser Pro Leu Leu Thr Phe Ser Lys 
            580                 585                 590         


Phe Cys Cys Thr Val Leu Leu Gln Ile Met Glu Arg Glu Ser Gly Asn 
        595                 600                 605             


Cys Pro Lys Asp Arg Tyr Val Val Cys Gly Arg Val Phe Leu Ser Leu 
    610                 615                 620                 


Glu Asp Leu Ser Thr Gly Lys Tyr Leu Leu Thr Phe Pro Lys Lys Lys 
625                 630                 635                 640 


Pro Ile Glu His Met Glu Asp Leu Phe Ala Leu Leu Ala Ala Phe His 
                645                 650                 655     


Lys Ser Cys Phe Gln Ile Thr Ser Pro Gly Tyr Ala Leu Asn Ser Met 
            660                 665                 670         


Lys Val Trp Leu Leu Glu His Met Lys Cys Glu Ile Ile Lys Glu Phe 
        675                 680                 685             


Pro Glu Val Tyr Phe Cys Glu Arg Pro Gly Ser Phe Tyr Gly Thr Leu 
    690                 695                 700                 


Phe Thr Trp Lys Gln Arg Thr Pro Phe Glu Gly Ile Leu Ile Ile Tyr 
705                 710                 715                 720 


Ser Arg Asn Gln Thr Val Met Phe Gln Cys Leu His Asn Leu Ile Arg 
                725                 730                 735     


Ile Leu Pro Ile Asn Cys Phe Leu Lys Asn Leu Lys Ser Gly Ser Glu 
            740                 745                 750         


Asn Phe Leu Ile Asp Asn Met Ala Phe Thr Leu Glu Lys Glu Leu Val 
        755                 760                 765             


Thr Leu Ser Ser Leu Ser Ser Ala Ile Ala Lys His Glu Ser Asn Phe 
    770                 775                 780                 


Met Gln Arg Cys Glu Val Ser Lys Gly Lys Ser Ser Val Val Ala Ala 
785                 790                 795                 800 


Ala Leu Ser Asp Arg Arg Glu Asn Ile His Pro Tyr Arg Lys Glu Leu 
                805                 810                 815     


Gln Arg Glu Lys Lys Lys Met Leu Gln Thr Asn Leu Lys Val Ser Gly 
            820                 825                 830         


Ala Leu Tyr Arg Glu Ile Thr Leu Lys Val Ala Glu Val Gln Leu Lys 
        835                 840                 845             


Ser Asp Phe Ala Ala Gln Lys Leu Ser Asn Leu 
    850                 855                 


<210>  111
<211>  1986
<212>  DNA
<213>  Homo sapiens

<400>  111
atggctccga gcgctgaccc cggcatgtcc aggatgttac cgttcctgct gctgctctgg       60

tttctgccca tcactgaggg gtcccagcgg gctgaaccca tgttcactgc agtcaccaac      120

tcagttctgc ctcctgacta tgacagtaat cccacccagc tcaactatgg tgtggcagtt      180

actgatgtgg accatgatgg ggactttgag atcgtcgtgg cggggtacaa tggacccaac      240

ctggttctga agtatgaccg ggcccagaag cggctggtga acatcgcggt cgatgagcgc      300

agctcaccct actacgcgct gcgggaccgg caggggaacg ccatcggggt cacagcctgc      360

gacatcgacg gggacggccg ggaggagatc tacttcctca acaccaataa tgccttctcg      420

ggggtggcca cgtacaccga caagttgttc aagttccgca ataaccggtg ggaagacatc      480

ctgagcgatg aggtcaacgt ggcccgtggt gtggccagcc tctttgccgg acgctctgtg      540

gcctgtgtgg acagaaaggg ctctggacgc tactctatct acattgccaa ttacgcctac      600

ggtaatgtgg gccctgatgc cctcattgaa atggaccctg aggccagtga cctctcccgg      660

ggcattctgg cgctcagaga tgtggctgct gaggctgggg tcagcaaata tacagggggc      720

cgaggcgtca gcgtgggccc catcctcagc agcagtgcct cggatatctt ctgcgacaat      780

gagaatgggc ctaacttcct tttccacaac cggggcgatg gcacctttgt ggacgctgcg      840

gccagtgctg gtgtggacga cccccaccag catgggcgag gtgtcgccct ggctgacttc      900

aaccgtgatg gcaaagtgga catcgtctat ggcaactgga atggccccca ccgcctctat      960

ctgcaaatga gcacccatgg gaaggtccgc ttccgggaca tcgcctcacc caagttctcc     1020

atgccctccc ctgtccgcac ggtcatcacc gccgactttg acaatgacca ggagctggag     1080

atcttcttca acaacattgc ctaccgcagc tcctcagcca accgcctctt ccgcgtcatc     1140

cgtagagagc acggagaccc cctcatcgag gagctcaatc ccggcgacgc cttggagcct     1200

gagggccggg gcacaggggg tgtggtgacc gacttcgacg gagacgggat gctggacctc     1260

atcttgtccc atggagagtc catggctcag ccgctgtccg tcttccgggg caatcagggc     1320

ttcaacaaca actggctgcg agtggtgcca cgcacccggt ttggggcctt tgccagggga     1380

gctaaggtcg tgctctacac caagaagagt ggggcccacc tgaggatcat cgacgggggc     1440

tcaggctacc tgtgtgagat ggagcccgtg gcacactttg gcctggggaa ggatgaagcc     1500

agcagtgtgg aggtgacgtg gccagatggc aagatggtga gccggaacgt ggccagcggg     1560

gagatgaact cagtgctgga gatcctctac ccccgggatg aggacacact tcaggaccca     1620

gccccactgg agtgtggcca aggattctcc cagcaggaaa atggccattg catggacacc     1680

aatgaatgca tccagttccc attcgtgtgc cctcgagaca agcccgtatg tgtcaacacc     1740

tatggaagct acaggtgccg gaccaacaag aagtgcagtc ggggctacga gcccaacgag     1800

gatggcacag cctgcgtggg gactctcggc cagtcaccgg gcccccgccc caccaccccc     1860

accgctgctg ctgccactgc cgctgctgct gccgctgctg gagctgccac tgctgcaccg     1920

gtcctcgtag atggagatct caatctgggg tcggtggtta aggagagctg cgagcccagc     1980

tgctga                                                                1986


<210>  112
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Pro Ser Ala Asp Pro Gly Met Ser Arg Met Leu Pro Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Phe Leu Pro Ile Thr Glu Gly Ser Gln Arg Ala Glu 
            20                  25                  30          


Pro Met Phe Thr Ala Val Thr Asn Ser Val Leu Pro Pro Asp Tyr Asp 
        35                  40                  45              


Ser Asn Pro Thr Gln Leu Asn Tyr Gly Val Ala Val Thr Asp Val Asp 
    50                  55                  60                  


His Asp Gly Asp Phe Glu Ile Val Val Ala Gly Tyr Asn Gly Pro Asn 
65                  70                  75                  80  


Leu Val Leu Lys Tyr Asp Arg Ala Gln Lys Arg Leu Val Asn Ile Ala 
                85                  90                  95      


Val Asp Glu Arg Ser Ser Pro Tyr Tyr Ala Leu Arg Asp Arg Gln Gly 
            100                 105                 110         


Asn Ala Ile Gly Val Thr Ala Cys Asp Ile Asp Gly Asp Gly Arg Glu 
        115                 120                 125             


Glu Ile Tyr Phe Leu Asn Thr Asn Asn Ala Phe Ser Gly Val Ala Thr 
    130                 135                 140                 


Tyr Thr Asp Lys Leu Phe Lys Phe Arg Asn Asn Arg Trp Glu Asp Ile 
145                 150                 155                 160 


Leu Ser Asp Glu Val Asn Val Ala Arg Gly Val Ala Ser Leu Phe Ala 
                165                 170                 175     


Gly Arg Ser Val Ala Cys Val Asp Arg Lys Gly Ser Gly Arg Tyr Ser 
            180                 185                 190         


Ile Tyr Ile Ala Asn Tyr Ala Tyr Gly Asn Val Gly Pro Asp Ala Leu 
        195                 200                 205             


Ile Glu Met Asp Pro Glu Ala Ser Asp Leu Ser Arg Gly Ile Leu Ala 
    210                 215                 220                 


Leu Arg Asp Val Ala Ala Glu Ala Gly Val Ser Lys Tyr Thr Gly Gly 
225                 230                 235                 240 


Arg Gly Val Ser Val Gly Pro Ile Leu Ser Ser Ser Ala Ser Asp Ile 
                245                 250                 255     


Phe Cys Asp Asn Glu Asn Gly Pro Asn Phe Leu Phe His Asn Arg Gly 
            260                 265                 270         


Asp Gly Thr Phe Val Asp Ala Ala Ala Ser Ala Gly Val Asp Asp Pro 
        275                 280                 285             


His Gln His Gly Arg Gly Val Ala Leu Ala Asp Phe Asn Arg Asp Gly 
    290                 295                 300                 


Lys Val Asp Ile Val Tyr Gly Asn Trp Asn Gly Pro His Arg Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Ser Thr His Gly Lys Val Arg Phe Arg Asp Ile Ala Ser 
                325                 330                 335     


Pro Lys Phe Ser Met Pro Ser Pro Val Arg Thr Val Ile Thr Ala Asp 
            340                 345                 350         


Phe Asp Asn Asp Gln Glu Leu Glu Ile Phe Phe Asn Asn Ile Ala Tyr 
        355                 360                 365             


Arg Ser Ser Ser Ala Asn Arg Leu Phe Arg Val Ile Arg Arg Glu His 
    370                 375                 380                 


Gly Asp Pro Leu Ile Glu Glu Leu Asn Pro Gly Asp Ala Leu Glu Pro 
385                 390                 395                 400 


Glu Gly Arg Gly Thr Gly Gly Val Val Thr Asp Phe Asp Gly Asp Gly 
                405                 410                 415     


Met Leu Asp Leu Ile Leu Ser His Gly Glu Ser Met Ala Gln Pro Leu 
            420                 425                 430         


Ser Val Phe Arg Gly Asn Gln Gly Phe Asn Asn Asn Trp Leu Arg Val 
        435                 440                 445             


Val Pro Arg Thr Arg Phe Gly Ala Phe Ala Arg Gly Ala Lys Val Val 
    450                 455                 460                 


Leu Tyr Thr Lys Lys Ser Gly Ala His Leu Arg Ile Ile Asp Gly Gly 
465                 470                 475                 480 


Ser Gly Tyr Leu Cys Glu Met Glu Pro Val Ala His Phe Gly Leu Gly 
                485                 490                 495     


Lys Asp Glu Ala Ser Ser Val Glu Val Thr Trp Pro Asp Gly Lys Met 
            500                 505                 510         


Val Ser Arg Asn Val Ala Ser Gly Glu Met Asn Ser Val Leu Glu Ile 
        515                 520                 525             


Leu Tyr Pro Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu 
    530                 535                 540                 


Cys Gly Gln Gly Phe Ser Gln Gln Glu Asn Gly His Cys Met Asp Thr 
545                 550                 555                 560 


Asn Glu Cys Ile Gln Phe Pro Phe Val Cys Pro Arg Asp Lys Pro Val 
                565                 570                 575     


Cys Val Asn Thr Tyr Gly Ser Tyr Arg Cys Arg Thr Asn Lys Lys Cys 
            580                 585                 590         


Ser Arg Gly Tyr Glu Pro Asn Glu Asp Gly Thr Ala Cys Val Gly Thr 
        595                 600                 605             


Leu Gly Gln Ser Pro Gly Pro Arg Pro Thr Thr Pro Thr Ala Ala Ala 
    610                 615                 620                 


Ala Thr Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Thr Ala Ala Pro 
625                 630                 635                 640 


Val Leu Val Asp Gly Asp Leu Asn Leu Gly Ser Val Val Lys Glu Ser 
                645                 650                 655     


Cys Glu Pro Ser Cys 
            660     


<210>  113
<211>  1170
<212>  DNA
<213>  Homo sapiens

<400>  113
atgctctccc tccgtgtccc gctcgcgccc atcacggacc cgcagcagct gcagctctcg       60

ccgctgaagg ggctcagctt ggtcgacaag gagaacacgc cgccggccct gagcgggacc      120

cgcgtcctgg ccagcaagac cgcgaggagg atcttccagg agcccacgga gccgaaaact      180

aaagcagctg cccccggcgt ggaggatgag ccgctgctga gagaaaaccc ccgccgcttt      240

gtcatcttcc ccatcgagta ccatgatatc tggcagatgt ataagaaggc agaggcttcc      300

ttttggaccg ccgaggaggt ggacctctcc aaggacattc agcactggga atccctgaaa      360

cccgaggaga gatattttat atcccatgtt ctggctttct ttgcagcaag cgatggcata      420

gtaaatgaaa acttggtgga gcgatttagc caagaagttc agattacaga agcccgctgt      480

ttctatggct tccaaattgc catggaaaac atacattctg aaatgtatag tcttcttatt      540

gacacttaca taaaagatcc caaagaaagg gaatttctct tcaatgccat tgaaacgatg      600

ccttgtgtca agaagaaggc agactgggcc ttgcgctgga ttggggacaa agaggctacc      660

tatggtgaac gtgttgtagc ctttgctgca gtggaaggca ttttcttttc cggttctttt      720

gcgtcgatat tctggctcaa gaaacgagga ctgatgcctg gcctcacatt ttctaatgaa      780

cttattagca gagatgaggg tttacactgt gattttgctt gcctgatgtt caaacacctg      840

gtacacaaac catcggagga gagagtaaga gaaataatta tcaatgctgt tcggatagaa      900

caggagttcc tcactgaggc cttgcctgtg aagctcattg ggatgaattg cactctaatg      960

aagcaataca ttgagtttgt ggcagacaga cttatgctgg aactgggttt tagcaaggtt     1020

ttcagagtag agaacccatt tgactttatg gagaatattt cactggaagg aaagactaac     1080

ttctttgaga agagagtagg cgagtatcag aggatgggag tgatgtcaag tccaacagag     1140

aattctttta ccttggatgc tgacttctaa                                      1170


<210>  114
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr Asp Pro Gln Gln 
1               5                   10                  15      


Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val Asp Lys Glu Asn 
            20                  25                  30          


Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala Ser Lys Thr Ala 
        35                  40                  45              


Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr Lys Ala Ala Ala 
    50                  55                  60                  


Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn Pro Arg Arg Phe 
65                  70                  75                  80  


Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln Met Tyr Lys Lys 
                85                  90                  95      


Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Lys Asp 
            100                 105                 110         


Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg Tyr Phe Ile Ser 
        115                 120                 125             


His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn Glu Asn 
    130                 135                 140                 


Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr Glu Ala Arg Cys 
145                 150                 155                 160 


Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr 
                165                 170                 175     


Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys Glu Arg Glu Phe 
            180                 185                 190         


Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys Lys Lys Ala Asp 
        195                 200                 205             


Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr Tyr Gly Glu Arg 
    210                 215                 220                 


Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 
225                 230                 235                 240 


Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 
                245                 250                 255     


Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 
            260                 265                 270         


Ala Cys Leu Met Phe Lys His Leu Val His Lys Pro Ser Glu Glu Arg 
        275                 280                 285             


Val Arg Glu Ile Ile Ile Asn Ala Val Arg Ile Glu Gln Glu Phe Leu 
    290                 295                 300                 


Thr Glu Ala Leu Pro Val Lys Leu Ile Gly Met Asn Cys Thr Leu Met 
305                 310                 315                 320 


Lys Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Met Leu Glu Leu Gly 
                325                 330                 335     


Phe Ser Lys Val Phe Arg Val Glu Asn Pro Phe Asp Phe Met Glu Asn 
            340                 345                 350         


Ile Ser Leu Glu Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 
        355                 360                 365             


Tyr Gln Arg Met Gly Val Met Ser Ser Pro Thr Glu Asn Ser Phe Thr 
    370                 375                 380                 


Leu Asp Ala Asp Phe 
385                 


<210>  115
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  115
atgtcctccg aggtgtccgc gcgccgcgac gccaagaagc tggtgcgctc cccgagcggc       60

ctgcgcatgg tgcccgaaca ccgcgccttc ggaagcccgt tcggcctgga ggagccgcag      120

tgggtcccgg acaaggagtg tcggagatgt atgcagtgtg acgccaagtt tgactttctc      180

accagaaagc accactgtcg ccgctgcggg aagtgcttct gcgacaggtg ctgcagccag      240

aaggtgccgc tgcggcgcat gtgctttgtg gaccccgtgc ggcagtgcgc ggagtgcgcc      300

ctcgtgtccc tcaaggaggc ggagttctac gacaagcagc tcaaagtgct cctgagcgga      360

gccaccttcc tcgtcacgtt tggaaactca gagaaacctg aaactatgac ttgtcgtctt      420

tccaataacc agagatactt gtttctggat ggagacagcc actatgaaat cgaaattgta      480

cacatttcca ccgtgcagat cctcacagaa ggcttccctc ctggaggagg caacgcacgg      540

gccacaggca tgttcctgca gtatacagtg ccggggacgg agggtgtgac ccagctgaag      600

ctgacagtgg tggaggacgt gactgtgggc aggaggcagg cggtggcgtg gctagtggcc      660

atgcacaagg ctgccaagct cctctatgaa tctcgggacc agtaa                      705


<210>  116
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ser Ser Glu Val Ser Ala Arg Arg Asp Ala Lys Lys Leu Val Arg 
1               5                   10                  15      


Ser Pro Ser Gly Leu Arg Met Val Pro Glu His Arg Ala Phe Gly Ser 
            20                  25                  30          


Pro Phe Gly Leu Glu Glu Pro Gln Trp Val Pro Asp Lys Glu Cys Arg 
        35                  40                  45              


Arg Cys Met Gln Cys Asp Ala Lys Phe Asp Phe Leu Thr Arg Lys His 
    50                  55                  60                  


His Cys Arg Arg Cys Gly Lys Cys Phe Cys Asp Arg Cys Cys Ser Gln 
65                  70                  75                  80  


Lys Val Pro Leu Arg Arg Met Cys Phe Val Asp Pro Val Arg Gln Cys 
                85                  90                  95      


Ala Glu Cys Ala Leu Val Ser Leu Lys Glu Ala Glu Phe Tyr Asp Lys 
            100                 105                 110         


Gln Leu Lys Val Leu Leu Ser Gly Ala Thr Phe Leu Val Thr Phe Gly 
        115                 120                 125             


Asn Ser Glu Lys Pro Glu Thr Met Thr Cys Arg Leu Ser Asn Asn Gln 
    130                 135                 140                 


Arg Tyr Leu Phe Leu Asp Gly Asp Ser His Tyr Glu Ile Glu Ile Val 
145                 150                 155                 160 


His Ile Ser Thr Val Gln Ile Leu Thr Glu Gly Phe Pro Pro Gly Gly 
                165                 170                 175     


Gly Asn Ala Arg Ala Thr Gly Met Phe Leu Gln Tyr Thr Val Pro Gly 
            180                 185                 190         


Thr Glu Gly Val Thr Gln Leu Lys Leu Thr Val Val Glu Asp Val Thr 
        195                 200                 205             


Val Gly Arg Arg Gln Ala Val Ala Trp Leu Val Ala Met His Lys Ala 
    210                 215                 220                 


Ala Lys Leu Leu Tyr Glu Ser Arg Asp Gln 
225                 230                 


<210>  117
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  117
atgagactcc tgggagctgc agccgtcgcg gctctggggc gcggaagggc ccccgcctcc       60

ctaggctggc agaggaagca ggttaattgg aaggcctgcc gatggtcttc atcaggggtg      120

attcctaatg aaaaaatacg aaatattgga atctcagctc acattgattc tgggaaaact      180

acattaacag aacgagtcct ttactacact ggcagaattg caaagatgca tgaggtgaaa      240

ggtaaagatg gagttggtgc tgtcatggat tccatggaac tagagagaca aagaggaatc      300

actattcagt cagcagccac ttacaccatg tggaaagatg tcaatattaa cattatagat      360

actcctgggc atgtggactt cacaatagaa gtggaaaggg ccctgagagt gttggatggt      420

gcagtccttg ttctctgtgc tgttggaggg gtacagtgcc agaccatgac tgtcaatcgt      480

cagatgaagc gctacaacgt tccgtttcta acttttatta acaaattgga ccgaatgggc      540

tccaacccag ccagggccct gcagcaaatg aggtctaaac taaatcataa tgcagcgttt      600

atgcagatac ccatgggttt ggagggtaat tttaaaggta ttgtagatct tattgaggaa      660

cgagccatct attttgatgg agactttggt cagattgttc gatatggtga gattccagct      720

gaattaaggg cggcggccac tgaccaccgg caggagctaa ttgaatgtgt tgccaattca      780

gatgaacagc ttggtgagat gtttctggaa gaaaaaatcc cctcgatttc tgatttaaag      840

ctagcaattc gaagagctac tctgaaaaga tcatttactc ctgtattttt gggaagcgcc      900

ttgaagaaca aaggagttca gcctctttta gatgctgttt tagaatacct cccaaatcca      960

tctgaagtcc agaactatgc tattctcaat aaagaggatg actcaaaaga gaaaaccaaa     1020

atcctaatga actccagtag agacaattcc cacccatttg taggcctggc ttttaaactg     1080

gaggtaggtc gatttggaca attaacttat gttcgcagtt atcagggaga gctaaagaag     1140

ggtgacacca tctataacac aaggacaaga aagaaagtac ggttgcaacg gctggctcgc     1200

atgcatgccg acatgatgga ggatgttgag gaagtatatg ccggagacat ctgtgcattg     1260

tttggcattg actgtgctag tggagacaca ttcacagaca aagccaacag cggcctttct     1320

atggagtcaa ttcatgttcc tgatcctgtc atttcaatag caatgaagcc ttctaacaag     1380

aacgatctgg aaaaattttc aaaaggtatt ggcaggttta caagagaaga tcccacattt     1440

aaagtatact ttgacactga gaacaaagag acagttatat ctggaatggg agaattacac     1500

ctggaaatct atgctcagag gctggaaaga gagtatggct gtccttgtat cacaggaaag     1560

ccaaaagttg cctttcgaga gaccattact gcccctgtcc cgtttgactt tacacataaa     1620

aaacaatcag gtggtgcagg ccagtatgga aaagtaatag gtgtcctgga gcctctggac     1680

ccagaggact acactaaatt ggaattttca gatgaaacat tcggatcaaa tattccaaag     1740

cagtttgtgc ctgctgtaga aaaggggttt ttagatgcct gcgagaaggg ccctctttct     1800

ggtcacaagc tctctgggct ccggtttgtc ctgcaagatg gagcacacca catggttgat     1860

tctaatgaaa tctctttcat ccgagcagga gaaggtgctc ttaaacaagc cttggcaaat     1920

gcaacattat gtattcttga acctattatg gctgtggaag ttgtagctcc aaatgaattt     1980

cagggacaag taattgcagg aattaaccga cgccatgggg taatcactgg gcaagatgga     2040

gttgaggact attttacact gtatgcagat gtccctctaa atgatatgtt tggttattcc     2100

actgaactta ggtcatgcac agagggaaag ggagaataca caatggagta tagcaggtat     2160

cagccatgtt taccatccac acaagaagac gtcattaata agtatttgga agctacaggt     2220

caacttcctg ttaaaaaagg aaaagccaag aactaa                               2256


<210>  118
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Arg Leu Leu Gly Ala Ala Ala Val Ala Ala Leu Gly Arg Gly Arg 
1               5                   10                  15      


Ala Pro Ala Ser Leu Gly Trp Gln Arg Lys Gln Val Asn Trp Lys Ala 
            20                  25                  30          


Cys Arg Trp Ser Ser Ser Gly Val Ile Pro Asn Glu Lys Ile Arg Asn 
        35                  40                  45              


Ile Gly Ile Ser Ala His Ile Asp Ser Gly Lys Thr Thr Leu Thr Glu 
    50                  55                  60                  


Arg Val Leu Tyr Tyr Thr Gly Arg Ile Ala Lys Met His Glu Val Lys 
65                  70                  75                  80  


Gly Lys Asp Gly Val Gly Ala Val Met Asp Ser Met Glu Leu Glu Arg 
                85                  90                  95      


Gln Arg Gly Ile Thr Ile Gln Ser Ala Ala Thr Tyr Thr Met Trp Lys 
            100                 105                 110         


Asp Val Asn Ile Asn Ile Ile Asp Thr Pro Gly His Val Asp Phe Thr 
        115                 120                 125             


Ile Glu Val Glu Arg Ala Leu Arg Val Leu Asp Gly Ala Val Leu Val 
    130                 135                 140                 


Leu Cys Ala Val Gly Gly Val Gln Cys Gln Thr Met Thr Val Asn Arg 
145                 150                 155                 160 


Gln Met Lys Arg Tyr Asn Val Pro Phe Leu Thr Phe Ile Asn Lys Leu 
                165                 170                 175     


Asp Arg Met Gly Ser Asn Pro Ala Arg Ala Leu Gln Gln Met Arg Ser 
            180                 185                 190         


Lys Leu Asn His Asn Ala Ala Phe Met Gln Ile Pro Met Gly Leu Glu 
        195                 200                 205             


Gly Asn Phe Lys Gly Ile Val Asp Leu Ile Glu Glu Arg Ala Ile Tyr 
    210                 215                 220                 


Phe Asp Gly Asp Phe Gly Gln Ile Val Arg Tyr Gly Glu Ile Pro Ala 
225                 230                 235                 240 


Glu Leu Arg Ala Ala Ala Thr Asp His Arg Gln Glu Leu Ile Glu Cys 
                245                 250                 255     


Val Ala Asn Ser Asp Glu Gln Leu Gly Glu Met Phe Leu Glu Glu Lys 
            260                 265                 270         


Ile Pro Ser Ile Ser Asp Leu Lys Leu Ala Ile Arg Arg Ala Thr Leu 
        275                 280                 285             


Lys Arg Ser Phe Thr Pro Val Phe Leu Gly Ser Ala Leu Lys Asn Lys 
    290                 295                 300                 


Gly Val Gln Pro Leu Leu Asp Ala Val Leu Glu Tyr Leu Pro Asn Pro 
305                 310                 315                 320 


Ser Glu Val Gln Asn Tyr Ala Ile Leu Asn Lys Glu Asp Asp Ser Lys 
                325                 330                 335     


Glu Lys Thr Lys Ile Leu Met Asn Ser Ser Arg Asp Asn Ser His Pro 
            340                 345                 350         


Phe Val Gly Leu Ala Phe Lys Leu Glu Val Gly Arg Phe Gly Gln Leu 
        355                 360                 365             


Thr Tyr Val Arg Ser Tyr Gln Gly Glu Leu Lys Lys Gly Asp Thr Ile 
    370                 375                 380                 


Tyr Asn Thr Arg Thr Arg Lys Lys Val Arg Leu Gln Arg Leu Ala Arg 
385                 390                 395                 400 


Met His Ala Asp Met Met Glu Asp Val Glu Glu Val Tyr Ala Gly Asp 
                405                 410                 415     


Ile Cys Ala Leu Phe Gly Ile Asp Cys Ala Ser Gly Asp Thr Phe Thr 
            420                 425                 430         


Asp Lys Ala Asn Ser Gly Leu Ser Met Glu Ser Ile His Val Pro Asp 
        435                 440                 445             


Pro Val Ile Ser Ile Ala Met Lys Pro Ser Asn Lys Asn Asp Leu Glu 
    450                 455                 460                 


Lys Phe Ser Lys Gly Ile Gly Arg Phe Thr Arg Glu Asp Pro Thr Phe 
465                 470                 475                 480 


Lys Val Tyr Phe Asp Thr Glu Asn Lys Glu Thr Val Ile Ser Gly Met 
                485                 490                 495     


Gly Glu Leu His Leu Glu Ile Tyr Ala Gln Arg Leu Glu Arg Glu Tyr 
            500                 505                 510         


Gly Cys Pro Cys Ile Thr Gly Lys Pro Lys Val Ala Phe Arg Glu Thr 
        515                 520                 525             


Ile Thr Ala Pro Val Pro Phe Asp Phe Thr His Lys Lys Gln Ser Gly 
    530                 535                 540                 


Gly Ala Gly Gln Tyr Gly Lys Val Ile Gly Val Leu Glu Pro Leu Asp 
545                 550                 555                 560 


Pro Glu Asp Tyr Thr Lys Leu Glu Phe Ser Asp Glu Thr Phe Gly Ser 
                565                 570                 575     


Asn Ile Pro Lys Gln Phe Val Pro Ala Val Glu Lys Gly Phe Leu Asp 
            580                 585                 590         


Ala Cys Glu Lys Gly Pro Leu Ser Gly His Lys Leu Ser Gly Leu Arg 
        595                 600                 605             


Phe Val Leu Gln Asp Gly Ala His His Met Val Asp Ser Asn Glu Ile 
    610                 615                 620                 


Ser Phe Ile Arg Ala Gly Glu Gly Ala Leu Lys Gln Ala Leu Ala Asn 
625                 630                 635                 640 


Ala Thr Leu Cys Ile Leu Glu Pro Ile Met Ala Val Glu Val Val Ala 
                645                 650                 655     


Pro Asn Glu Phe Gln Gly Gln Val Ile Ala Gly Ile Asn Arg Arg His 
            660                 665                 670         


Gly Val Ile Thr Gly Gln Asp Gly Val Glu Asp Tyr Phe Thr Leu Tyr 
        675                 680                 685             


Ala Asp Val Pro Leu Asn Asp Met Phe Gly Tyr Ser Thr Glu Leu Arg 
    690                 695                 700                 


Ser Cys Thr Glu Gly Lys Gly Glu Tyr Thr Met Glu Tyr Ser Arg Tyr 
705                 710                 715                 720 


Gln Pro Cys Leu Pro Ser Thr Gln Glu Asp Val Ile Asn Lys Tyr Leu 
                725                 730                 735     


Glu Ala Thr Gly Gln Leu Pro Val Lys Lys Gly Lys Ala Lys Asn 
            740                 745                 750     


<210>  119
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  119
atgaggatgg actctcagaa aaaaattgcc aaaataaatg tcggtaagag aattgccctg       60

gtggaaaata ttcctgaagg ccttaactat tcagaaaatg caccatttca cttatcactt      120

ttccaaggct ggatgaattt actcaacatg gccaaaaagt ctgttgacat agtgtcttcc      180

cattgggatc tcaaccacac tcatccatca gcatgtcagg gtcaacgtct ttttgaaaag      240

ttgctccagc tgacttcgca aaatattgaa atcaagctag tgagtgatgt aacagctgat      300

tcaaaggtat tagaagcctt gaaattaaag ggagccgagg tgacgtacat gaacatgacc      360

gcttacaaca agggccggct gcagtcctcc ttctggatcg tggacaaaca gcacgtgtat      420

atcggcagtg ccggtttgga ctggcaatcc ctgggacaga tgaaagaact cggtgtcatc      480

ttctacaact gcagctgcct ggtcctagat ttacaaagga tatttgctct atatagttca      540

ttaaaattca aaagcagagt gcctcaaacc tggtccaaaa gactctatgg agtctatgac      600

aatgaaaaga aattgcaact tcagttgaat gaaaccaaat ctcaagcatt tgtatcgaat      660

tctccaaaac tcttttgccc taaaaacaga agttttgaca tagatgccat ctacagtgtg      720

atagatgatg ccaagcagta tgtgtacatc gctgtcatgg actacctgcc tatctccagc      780

acaagcacca aaaggactta ctggccagac ttggatgcaa aaataagaga agcattagtt      840

ttacgaagcg ttagagttcg actcctttta agcttctgga aggaaactga tccccttacg      900

tttaacttta tttcatctct taaagcgatt tgcactgaaa tagccaactg cagtttgaaa      960

gttaaatttt ttgatctgga aagagagaat gcttgtgcta caaaagaaca aaagaatcac     1020

acctttccta ggttaaatcg caacaagtac atggtgacag atggagcagc ttatattgga     1080

aattttgatt gggtagggaa tgatttcact cagaatgctg gcacgggcct tgttatcaac     1140

caggcagatg tgaggaacaa cagaagcatc attaagcaac ttaaagatgt gtttgaaagg     1200

gactggtatt caccgtatgc caaaacctta cagccaacca aacagccgaa ctgctcaagc     1260

ctgttcaaac tcaaacccct ctccaacaaa actgccacag acgacacagg cggaaaggat     1320

ccccggaacg tataa                                                      1335


<210>  120
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Arg Met Asp Ser Gln Lys Lys Ile Ala Lys Ile Asn Val Gly Lys 
1               5                   10                  15      


Arg Ile Ala Leu Val Glu Asn Ile Pro Glu Gly Leu Asn Tyr Ser Glu 
            20                  25                  30          


Asn Ala Pro Phe His Leu Ser Leu Phe Gln Gly Trp Met Asn Leu Leu 
        35                  40                  45              


Asn Met Ala Lys Lys Ser Val Asp Ile Val Ser Ser His Trp Asp Leu 
    50                  55                  60                  


Asn His Thr His Pro Ser Ala Cys Gln Gly Gln Arg Leu Phe Glu Lys 
65                  70                  75                  80  


Leu Leu Gln Leu Thr Ser Gln Asn Ile Glu Ile Lys Leu Val Ser Asp 
                85                  90                  95      


Val Thr Ala Asp Ser Lys Val Leu Glu Ala Leu Lys Leu Lys Gly Ala 
            100                 105                 110         


Glu Val Thr Tyr Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln 
        115                 120                 125             


Ser Ser Phe Trp Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala 
    130                 135                 140                 


Gly Leu Asp Trp Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile 
145                 150                 155                 160 


Phe Tyr Asn Cys Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala 
                165                 170                 175     


Leu Tyr Ser Ser Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser 
            180                 185                 190         


Lys Arg Leu Tyr Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln 
        195                 200                 205             


Leu Asn Glu Thr Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu 
    210                 215                 220                 


Phe Cys Pro Lys Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val 
225                 230                 235                 240 


Ile Asp Asp Ala Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu 
                245                 250                 255     


Pro Ile Ser Ser Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp 
            260                 265                 270         


Ala Lys Ile Arg Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu 
        275                 280                 285             


Leu Leu Ser Phe Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile 
    290                 295                 300                 


Ser Ser Leu Lys Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys 
305                 310                 315                 320 


Val Lys Phe Phe Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu 
                325                 330                 335     


Gln Lys Asn His Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val 
            340                 345                 350         


Thr Asp Gly Ala Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp 
        355                 360                 365             


Phe Thr Gln Asn Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val 
    370                 375                 380                 


Arg Asn Asn Arg Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg 
385                 390                 395                 400 


Asp Trp Tyr Ser Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro 
                405                 410                 415     


Asn Cys Ser Ser Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala 
            420                 425                 430         


Thr Asp Asp Thr Gly Gly Lys Asp Pro Arg Asn Val 
        435                 440                 


<210>  121
<211>  5759
<212>  DNA
<213>  Homo sapiens

<400>  121
gcgatcgcca tgatgctcac cccagcagga ccagagcacc gaggcccaag gccccagcct       60

gccatgccgc tgccaccgcg gagcctgcag gtgctcctgc tgctgctgct gttgctgctg      120

ctgctgccgg gcatgtgggc tgaggcaggc ttgcccaggg caggcggggg ttcacagccc      180

cccttccgca ccttctcggc cagcgactgg ggcctcaccc acctagtggt gcatgagcag      240

acaggcgagg tgtatgtggg cgcagtgaac cgcatctata agctgtcggg gaacctgaca      300

ctgctgcggg cccacgtcac gggccctgtg gaggacaacg agaagtgcta cccgccgccc      360

agcgtgcagt cctgccccca cggcctgggc agtactgaca acgtcaacaa gctgctgctg      420

ctggactatg ccgctaaccg cctgctggcc tgtggcagcg cctcccaggg catctgccag      480

ttcctgcgtc tggacgatct cttcaaactg ggtgagccac accaccgtaa ggagcactac      540

ctgtccagcg tgcaggaggc aggcagcatg gcgggcgtgc tcattgccgg gccaccgggc      600

cagggccagg ccaagctctt cgtgggcaca cccatcgatg gcaagtccga gtacttcccc      660

acactgtcca gccgtcggct catggccaac gaggaggatg ccgacatgtt cggcttcgtg      720

taccaggatg agtttgtgtc atcacagctc aagatccctt cggacacgct gtccaagttc      780

ccggcctttg acatctacta tgtgtacagc ttccgcagcg agcagtttgt ctactacctc      840

acgctgcagc tagacacaca gctgacctcg cctgatgccg ccggcgagca cttcttcacg      900

tccaagatcg tgcggctctg tgtggacgac cccaaattct actcgtacgt tgagttcccc      960

attggctgcg agcaggcggg tgtggagtac cgcctggtgc aggatgccta cctgagccgg     1020

cccggccgtg ccctggccca ccagctgggc ctggctgagg acgaggacgt gctgttcact     1080

gtgttcgccc agggccagaa gaaccgcgtg aagccaccaa aggagtcagc actgtgcctg     1140

ttcacgctca gggccatcaa ggagaagatt aaggagcgca tccagtcctg ctaccgtggt     1200

gagggcaagc tctccctgcc gtggctgctc aacaaggagc tgggctgcat caactcgccc     1260

ctgcagatcg atgacgactt ctgcgggcag gacttcaacc agcccctggg gggcacagtc     1320

accattgagg ggacgcccct gttcgtggac aaggatgatg gcctgaccgc cgtggctgcc     1380

tatgactatc ggggccgcac tgtggtattc gccggcacgc gaagtggccg catccgcaag     1440

atcctggtgg acctctcaaa ccccggtggc cggcctgccc tggcctacga gagcgtcgtg     1500

gcccaggagg gcagccccat cctgcgagac ctcgtcctca gccccaacca ccagtacctc     1560

tacgccatga ccgagaagca ggtgacgcgg gtgcctgtgg agagctgtgt gcagtacacg     1620

tcctgtgagc tgtgtctggg gtcacgggac ccccactgtg gctggtgtgt cctgcacagc     1680

atctgctcgc ggcgggacgc ctgtgagcga gcagacgagc cccagcgctt tgctgcggac     1740

ctgctgcagt gtgtgcagct gactgtgcag ccccgcaatg tgtctgtcac catgtcccag     1800

gtcccacttg tgctgcaggc ctggaacgtg cctgacctct cagctggcgt caactgctcc     1860

ttcgaggact tcacggaatc tgagagcgtc ctggaggatg gccggatcca ctgccgctca     1920

ccctccgccc gggaggtggc gcccatcacg cggggccagg gagaccagcg ggtggtgaaa     1980

ctctacctaa agtccaagga gacagggaag aagtttgcgt ctgtggactt cgtcttctac     2040

aactgcagcg tccaccagtc ctgcctgtcc tgtgtcaacg gctcctttcc ctgccactgg     2100

tgcaaatacc gccacgtgtg cacacacaac gtggctgact gcgccttcct ggagggccgt     2160

gtcaacgtgt ctgaggactg cccacagatc ctgccctcca cgcagatcta cgtgccagtg     2220

ggagtggtaa aacccatcac cctggccgca cggaacctgc cacagccaca gtcaggccag     2280

cgtggatatg agtgcctctt ccacatcccg ggcagcccgg cccgtgtcac cgccctgcgc     2340

ttcaacagct ccagcctgca gtgccagaat tcctcgtact cctacgaggg gaacgatgtc     2400

agcgacctgc cagtgaacct gtcagtcgtg tggaacggca actttgtcat tgacaaccca     2460

cagaacatcc aggcgcacct ctacaagtgc ccggccctgc gcgagagctg cggcctctgc     2520

ctcaaggccg acccgcgctt cgagtgcgga tggtgcgtgg ccgagcgccg ctgctccctg     2580

cgacaccact gcgctgccga cacacctgca tcgtggatgc acgcgcgtca cggcagcagt     2640

cgctgcaccg accccaagat cctcaagctg tcccccgaga cgggcccgag gcagggcggc     2700

acgcggctca ctatcacagg cgagaacctg ggcctgcgat tcgaagacgt gcgtctgggc     2760

gtgcgcgtgg gcaaggtgct gtgcagccct gtggagagcg agtacatcag tgcggagcag     2820

atcgtctgtg agatcgggga cgccagctcc gtgcgtgccc atgacgccct ggtggaggtg     2880

tgtgtgcggg actgctcacc acactaccgc gccctgtcac ccaagcgctt caccttcgtg     2940

acaccaacct tctaccgtgt gagcccctcc cgtgggcctc tgtcaggggg cacctggatt     3000

ggcatcgagg gaagccacct gaacgcaggc agtgatgtgg ctgtgtcggt cggtggccgg     3060

ccctgctcct tctcctggag gaactcccgt gagatccggt gcctgacacc ccccgggcag     3120

agccctggca gcgctcccat catcatcaac atcaaccgcg cccagctcac caaccctgag     3180

gtgaagtaca actacaccga ggaccccacc atcctgagga tcgaccccga gtggagcatc     3240

aacagcggtg ggaccctcct gacggtcaca ggcaccaacc tggccactgt ccgtgaaccc     3300

cgaatccggg ccaagtatgg aggcattgag agggagaacg gctgcctggt gtacaatgac     3360

accaccatgg tatgccgcgc cccgtctgtg gccaaccctg tgcgcagccc accagagctg     3420

ggggagcggc cggatgagct gggcttcgtc atggacaacg tgcgctccct gcttgtgctc     3480

aactccacct ccttcctcta ctaccctgac cccgtactgg agccactcag ccccactggc     3540

ctgctggagc tgaagcccag ctccccactc atcctcaagg gccggaacct cttgccacct     3600

gcacccggca actcccgact caactacacg gtgctcatcg gctccacacc ctgtaccctc     3660

accgtgtcgg agacgcaact gctgtgcgag gcgcccaacc tcactgggca gcacaaggtc     3720

acggtgcggg caggtggctt cgagttctcg ccagggacac tgcaggtgta ctcggacagc     3780

ctgctgacgc tgcctgccat tgtgggcatt ggcggaggcg ggggtctcct gctgctggtc     3840

atcgtggctg tgctaatcgc ctacaagcgc aagtcacgag atgctgaccg cacactcaag     3900

cggctgcagc tccagatgga caacctggag tcccgcgtgg ccctcgaatg caaggaagcc     3960

tttgcagagc tgcagacaga catccacgag ctgaccaatg acctggacgg tgccggcatc     4020

cccttccttg actaccggac atatgccatg cgggtgctct ttcctgggat cgaggaccac     4080

cctgtgctca aggagatgga ggtgcaggcc aatgtggaga agtcgctgac actgttcggg     4140

cagctgctga ccaagaagca cttcctgctg accttcatcc gcacgctgga ggcacagcgc     4200

agcttctcca tgcgcgaccg cgggaatgtg gcctcgctca tcatgacggc cctgcagggc     4260

gagatggaat acgccacagg cgtgctcaag cagctgcttt ccgacctcat cgagaagaac     4320

ctggagagca agaaccaccc caagctgcta ctgcgccgga ctgagtcggt ggcagagaag     4380

atgctaacta actggttcac cttcctcttg tataagttcc tcaaggagtg cgctggggag     4440

ccgctgttca tgctgtactg cgccatcaag cagcagatgg agaagggccc cattgacgcc     4500

atcacgggtg aggcacgcta ctccctgagt gaggacaagc tcatccggca gcagattgac     4560

tacaagacac tgaccctgaa ctgtgtgaac cctgagaatg agaatgcacc tgaggtgccg     4620

gtgaaggggc tggactgtga cacggtcacc caggccaagg agaagctgct ggacgctgcc     4680

tacaagggcg tgccctactc ccagcggccc aaggccgcgg acatggacct ggagtggcgc     4740

cagggccgca tggcgcgcat catcctgcag gacgaggacg tcaccaccaa gattgacaac     4800

gattggaaga ggctgaacac actggctcac taccaggtga cagacgggtc ctcggtggca     4860

ctggtgccca agcagacgtc cgcctacaac atctccaact cctccacctt caccaagtcc     4920

ctcagcagat acgagagcat gctgcgcacg gccagcagcc ccgacagcct gcgctcgcgc     4980

acgcccatga tcacgcccga cctggagagc ggcaccaagc tgtggcacct ggtgaagaac     5040

cacgaccacc tggaccagcg tgagggtgac cgcggcagca agatggtctc ggagatctac     5100

ttgacacggc tactggccac caagggcaca ctgcagaagt ttgtggacga cctgtttgag     5160

accatcttca gcacggcaca ccggggctca gccctgccgc tggccatcaa gtacatgttc     5220

gacttcctgg atgagcaggc cgacaagcac cagatccacg atgctgacgt gcgccacacc     5280

tggaagagca actgcctgcc cctgcgcttc tgggtgaacg tgatcaagaa cccacagttt     5340

gtgttcgaca ttcacaagaa cagcatcacg gacgcctgct tgtcggtggt ggcccagacc     5400

ttcatggact cctgctccac ctctgagcac aagctgggca aggactcacc ctccaacaag     5460

ctgctctacg ccaaggacat ccccaactac aagagctggg tggagaggta ctatgcagac     5520

atcgccaaga tgccagccat cagcgaccag gacatgagtg cgtatctggc tgagcagtcc     5580

cgcctgcacc tgagccagtt caacagcatg agcgccttgc acgagatcta ctcctacatc     5640

accaagtaca aggatgagat cctggcagcc ctggagaagg atgagcaggc gcggcggcag     5700

cggctgcgga gcaagctgga gcaggtggtg gacacgatgg ccctgagcag cgtttaaac      5759


<210>  122
<211>  1914
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Met Leu Thr Pro Ala Gly Pro Glu His Arg Gly Pro Arg Pro Gln 
1               5                   10                  15      


Pro Ala Met Pro Leu Pro Pro Arg Ser Leu Gln Val Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Pro Gly Met Trp Ala Glu Ala Gly Leu 
        35                  40                  45              


Pro Arg Ala Gly Gly Gly Ser Gln Pro Pro Phe Arg Thr Phe Ser Ala 
    50                  55                  60                  


Ser Asp Trp Gly Leu Thr His Leu Val Val His Glu Gln Thr Gly Glu 
65                  70                  75                  80  


Val Tyr Val Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Gly Asn Leu 
                85                  90                  95      


Thr Leu Leu Arg Ala His Val Thr Gly Pro Val Glu Asp Asn Glu Lys 
            100                 105                 110         


Cys Tyr Pro Pro Pro Ser Val Gln Ser Cys Pro His Gly Leu Gly Ser 
        115                 120                 125             


Thr Asp Asn Val Asn Lys Leu Leu Leu Leu Asp Tyr Ala Ala Asn Arg 
    130                 135                 140                 


Leu Leu Ala Cys Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg 
145                 150                 155                 160 


Leu Asp Asp Leu Phe Lys Leu Gly Glu Pro His His Arg Lys Glu His 
                165                 170                 175     


Tyr Leu Ser Ser Val Gln Glu Ala Gly Ser Met Ala Gly Val Leu Ile 
            180                 185                 190         


Ala Gly Pro Pro Gly Gln Gly Gln Ala Lys Leu Phe Val Gly Thr Pro 
        195                 200                 205             


Ile Asp Gly Lys Ser Glu Tyr Phe Pro Thr Leu Ser Ser Arg Arg Leu 
    210                 215                 220                 


Met Ala Asn Glu Glu Asp Ala Asp Met Phe Gly Phe Val Tyr Gln Asp 
225                 230                 235                 240 


Glu Phe Val Ser Ser Gln Leu Lys Ile Pro Ser Asp Thr Leu Ser Lys 
                245                 250                 255     


Phe Pro Ala Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Arg Ser Glu Gln 
            260                 265                 270         


Phe Val Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu Thr Ser Pro 
        275                 280                 285             


Asp Ala Ala Gly Glu His Phe Phe Thr Ser Lys Ile Val Arg Leu Cys 
    290                 295                 300                 


Val Asp Asp Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys 
305                 310                 315                 320 


Glu Gln Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala Tyr Leu Ser 
                325                 330                 335     


Arg Pro Gly Arg Ala Leu Ala His Gln Leu Gly Leu Ala Glu Asp Glu 
            340                 345                 350         


Asp Val Leu Phe Thr Val Phe Ala Gln Gly Gln Lys Asn Arg Val Lys 
        355                 360                 365             


Pro Pro Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg Ala Ile Lys 
    370                 375                 380                 


Glu Lys Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Lys 
385                 390                 395                 400 


Leu Ser Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser 
                405                 410                 415     


Pro Leu Gln Ile Asp Asp Asp Phe Cys Gly Gln Asp Phe Asn Gln Pro 
            420                 425                 430         


Leu Gly Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Val Asp Lys 
        435                 440                 445             


Asp Asp Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Arg Gly Arg Thr 
    450                 455                 460                 


Val Val Phe Ala Gly Thr Arg Ser Gly Arg Ile Arg Lys Ile Leu Val 
465                 470                 475                 480 


Asp Leu Ser Asn Pro Gly Gly Arg Pro Ala Leu Ala Tyr Glu Ser Val 
                485                 490                 495     


Val Ala Gln Glu Gly Ser Pro Ile Leu Arg Asp Leu Val Leu Ser Pro 
            500                 505                 510         


Asn His Gln Tyr Leu Tyr Ala Met Thr Glu Lys Gln Val Thr Arg Val 
        515                 520                 525             


Pro Val Glu Ser Cys Val Gln Tyr Thr Ser Cys Glu Leu Cys Leu Gly 
    530                 535                 540                 


Ser Arg Asp Pro His Cys Gly Trp Cys Val Leu His Ser Ile Cys Ser 
545                 550                 555                 560 


Arg Arg Asp Ala Cys Glu Arg Ala Asp Glu Pro Gln Arg Phe Ala Ala 
                565                 570                 575     


Asp Leu Leu Gln Cys Val Gln Leu Thr Val Gln Pro Arg Asn Val Ser 
            580                 585                 590         


Val Thr Met Ser Gln Val Pro Leu Val Leu Gln Ala Trp Asn Val Pro 
        595                 600                 605             


Asp Leu Ser Ala Gly Val Asn Cys Ser Phe Glu Asp Phe Thr Glu Ser 
    610                 615                 620                 


Glu Ser Val Leu Glu Asp Gly Arg Ile His Cys Arg Ser Pro Ser Ala 
625                 630                 635                 640 


Arg Glu Val Ala Pro Ile Thr Arg Gly Gln Gly Asp Gln Arg Val Val 
                645                 650                 655     


Lys Leu Tyr Leu Lys Ser Lys Glu Thr Gly Lys Lys Phe Ala Ser Val 
            660                 665                 670         


Asp Phe Val Phe Tyr Asn Cys Ser Val His Gln Ser Cys Leu Ser Cys 
        675                 680                 685             


Val Asn Gly Ser Phe Pro Cys His Trp Cys Lys Tyr Arg His Val Cys 
    690                 695                 700                 


Thr His Asn Val Ala Asp Cys Ala Phe Leu Glu Gly Arg Val Asn Val 
705                 710                 715                 720 


Ser Glu Asp Cys Pro Gln Ile Leu Pro Ser Thr Gln Ile Tyr Val Pro 
                725                 730                 735     


Val Gly Val Val Lys Pro Ile Thr Leu Ala Ala Arg Asn Leu Pro Gln 
            740                 745                 750         


Pro Gln Ser Gly Gln Arg Gly Tyr Glu Cys Leu Phe His Ile Pro Gly 
        755                 760                 765             


Ser Pro Ala Arg Val Thr Ala Leu Arg Phe Asn Ser Ser Ser Leu Gln 
    770                 775                 780                 


Cys Gln Asn Ser Ser Tyr Ser Tyr Glu Gly Asn Asp Val Ser Asp Leu 
785                 790                 795                 800 


Pro Val Asn Leu Ser Val Val Trp Asn Gly Asn Phe Val Ile Asp Asn 
                805                 810                 815     


Pro Gln Asn Ile Gln Ala His Leu Tyr Lys Cys Pro Ala Leu Arg Glu 
            820                 825                 830         


Ser Cys Gly Leu Cys Leu Lys Ala Asp Pro Arg Phe Glu Cys Gly Trp 
        835                 840                 845             


Cys Val Ala Glu Arg Arg Cys Ser Leu Arg His His Cys Ala Ala Asp 
    850                 855                 860                 


Thr Pro Ala Ser Trp Met His Ala Arg His Gly Ser Ser Arg Cys Thr 
865                 870                 875                 880 


Asp Pro Lys Ile Leu Lys Leu Ser Pro Glu Thr Gly Pro Arg Gln Gly 
                885                 890                 895     


Gly Thr Arg Leu Thr Ile Thr Gly Glu Asn Leu Gly Leu Arg Phe Glu 
            900                 905                 910         


Asp Val Arg Leu Gly Val Arg Val Gly Lys Val Leu Cys Ser Pro Val 
        915                 920                 925             


Glu Ser Glu Tyr Ile Ser Ala Glu Gln Ile Val Cys Glu Ile Gly Asp 
    930                 935                 940                 


Ala Ser Ser Val Arg Ala His Asp Ala Leu Val Glu Val Cys Val Arg 
945                 950                 955                 960 


Asp Cys Ser Pro His Tyr Arg Ala Leu Ser Pro Lys Arg Phe Thr Phe 
                965                 970                 975     


Val Thr Pro Thr Phe Tyr Arg Val Ser Pro Ser Arg Gly Pro Leu Ser 
            980                 985                 990         


Gly Gly Thr Trp Ile Gly Ile Glu  Gly Ser His Leu Asn  Ala Gly Ser 
        995                 1000                 1005             


Asp Val  Ala Val Ser Val Gly  Gly Arg Pro Cys Ser  Phe Ser Trp 
    1010                 1015                 1020             


Arg Asn  Ser Arg Glu Ile Arg  Cys Leu Thr Pro Pro  Gly Gln Ser 
    1025                 1030                 1035             


Pro Gly  Ser Ala Pro Ile Ile  Ile Asn Ile Asn Arg  Ala Gln Leu 
    1040                 1045                 1050             


Thr Asn  Pro Glu Val Lys Tyr  Asn Tyr Thr Glu Asp  Pro Thr Ile 
    1055                 1060                 1065             


Leu Arg  Ile Asp Pro Glu Trp  Ser Ile Asn Ser Gly  Gly Thr Leu 
    1070                 1075                 1080             


Leu Thr  Val Thr Gly Thr Asn  Leu Ala Thr Val Arg  Glu Pro Arg 
    1085                 1090                 1095             


Ile Arg  Ala Lys Tyr Gly Gly  Ile Glu Arg Glu Asn  Gly Cys Leu 
    1100                 1105                 1110             


Val Tyr  Asn Asp Thr Thr Met  Val Cys Arg Ala Pro  Ser Val Ala 
    1115                 1120                 1125             


Asn Pro  Val Arg Ser Pro Pro  Glu Leu Gly Glu Arg  Pro Asp Glu 
    1130                 1135                 1140             


Leu Gly  Phe Val Met Asp Asn  Val Arg Ser Leu Leu  Val Leu Asn 
    1145                 1150                 1155             


Ser Thr  Ser Phe Leu Tyr Tyr  Pro Asp Pro Val Leu  Glu Pro Leu 
    1160                 1165                 1170             


Ser Pro  Thr Gly Leu Leu Glu  Leu Lys Pro Ser Ser  Pro Leu Ile 
    1175                 1180                 1185             


Leu Lys  Gly Arg Asn Leu Leu  Pro Pro Ala Pro Gly  Asn Ser Arg 
    1190                 1195                 1200             


Leu Asn  Tyr Thr Val Leu Ile  Gly Ser Thr Pro Cys  Thr Leu Thr 
    1205                 1210                 1215             


Val Ser  Glu Thr Gln Leu Leu  Cys Glu Ala Pro Asn  Leu Thr Gly 
    1220                 1225                 1230             


Gln His  Lys Val Thr Val Arg  Ala Gly Gly Phe Glu  Phe Ser Pro 
    1235                 1240                 1245             


Gly Thr  Leu Gln Val Tyr Ser  Asp Ser Leu Leu Thr  Leu Pro Ala 
    1250                 1255                 1260             


Ile Val  Gly Ile Gly Gly Gly  Gly Gly Leu Leu Leu  Leu Val Ile 
    1265                 1270                 1275             


Val Ala  Val Leu Ile Ala Tyr  Lys Arg Lys Ser Arg  Asp Ala Asp 
    1280                 1285                 1290             


Arg Thr  Leu Lys Arg Leu Gln  Leu Gln Met Asp Asn  Leu Glu Ser 
    1295                 1300                 1305             


Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe Ala Glu  Leu Gln Thr 
    1310                 1315                 1320             


Asp Ile  His Glu Leu Thr Asn  Asp Leu Asp Gly Ala  Gly Ile Pro 
    1325                 1330                 1335             


Phe Leu  Asp Tyr Arg Thr Tyr  Ala Met Arg Val Leu  Phe Pro Gly 
    1340                 1345                 1350             


Ile Glu  Asp His Pro Val Leu  Lys Glu Met Glu Val  Gln Ala Asn 
    1355                 1360                 1365             


Val Glu  Lys Ser Leu Thr Leu  Phe Gly Gln Leu Leu  Thr Lys Lys 
    1370                 1375                 1380             


His Phe  Leu Leu Thr Phe Ile  Arg Thr Leu Glu Ala  Gln Arg Ser 
    1385                 1390                 1395             


Phe Ser  Met Arg Asp Arg Gly  Asn Val Ala Ser Leu  Ile Met Thr 
    1400                 1405                 1410             


Ala Leu  Gln Gly Glu Met Glu  Tyr Ala Thr Gly Val  Leu Lys Gln 
    1415                 1420                 1425             


Leu Leu  Ser Asp Leu Ile Glu  Lys Asn Leu Glu Ser  Lys Asn His 
    1430                 1435                 1440             


Pro Lys  Leu Leu Leu Arg Arg  Thr Glu Ser Val Ala  Glu Lys Met 
    1445                 1450                 1455             


Leu Thr  Asn Trp Phe Thr Phe  Leu Leu Tyr Lys Phe  Leu Lys Glu 
    1460                 1465                 1470             


Cys Ala  Gly Glu Pro Leu Phe  Met Leu Tyr Cys Ala  Ile Lys Gln 
    1475                 1480                 1485             


Gln Met  Glu Lys Gly Pro Ile  Asp Ala Ile Thr Gly  Glu Ala Arg 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Glu Asp Lys  Leu Ile Arg Gln Gln  Ile Asp Tyr 
    1505                 1510                 1515             


Lys Thr  Leu Thr Leu Asn Cys  Val Asn Pro Glu Asn  Glu Asn Ala 
    1520                 1525                 1530             


Pro Glu  Val Pro Val Lys Gly  Leu Asp Cys Asp Thr  Val Thr Gln 
    1535                 1540                 1545             


Ala Lys  Glu Lys Leu Leu Asp  Ala Ala Tyr Lys Gly  Val Pro Tyr 
    1550                 1555                 1560             


Ser Gln  Arg Pro Lys Ala Ala  Asp Met Asp Leu Glu  Trp Arg Gln 
    1565                 1570                 1575             


Gly Arg  Met Ala Arg Ile Ile  Leu Gln Asp Glu Asp  Val Thr Thr 
    1580                 1585                 1590             


Lys Ile  Asp Asn Asp Trp Lys  Arg Leu Asn Thr Leu  Ala His Tyr 
    1595                 1600                 1605             


Gln Val  Thr Asp Gly Ser Ser  Val Ala Leu Val Pro  Lys Gln Thr 
    1610                 1615                 1620             


Ser Ala  Tyr Asn Ile Ser Asn  Ser Ser Thr Phe Thr  Lys Ser Leu 
    1625                 1630                 1635             


Ser Arg  Tyr Glu Ser Met Leu  Arg Thr Ala Ser Ser  Pro Asp Ser 
    1640                 1645                 1650             


Leu Arg  Ser Arg Thr Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly 
    1655                 1660                 1665             


Thr Lys  Leu Trp His Leu Val  Lys Asn His Asp His  Leu Asp Gln 
    1670                 1675                 1680             


Arg Glu  Gly Asp Arg Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu 
    1685                 1690                 1695             


Thr Arg  Leu Leu Ala Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp 
    1700                 1705                 1710             


Asp Leu  Phe Glu Thr Ile Phe  Ser Thr Ala His Arg  Gly Ser Ala 
    1715                 1720                 1725             


Leu Pro  Leu Ala Ile Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln 
    1730                 1735                 1740             


Ala Asp  Lys His Gln Ile His  Asp Ala Asp Val Arg  His Thr Trp 
    1745                 1750                 1755             


Lys Ser  Asn Cys Leu Pro Leu  Arg Phe Trp Val Asn  Val Ile Lys 
    1760                 1765                 1770             


Asn Pro  Gln Phe Val Phe Asp  Ile His Lys Asn Ser  Ile Thr Asp 
    1775                 1780                 1785             


Ala Cys  Leu Ser Val Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser 
    1790                 1795                 1800             


Thr Ser  Glu His Lys Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu 
    1805                 1810                 1815             


Leu Tyr  Ala Lys Asp Ile Pro  Asn Tyr Lys Ser Trp  Val Glu Arg 
    1820                 1825                 1830             


Tyr Tyr  Ala Asp Ile Ala Lys  Met Pro Ala Ile Ser  Asp Gln Asp 
    1835                 1840                 1845             


Met Ser  Ala Tyr Leu Ala Glu  Gln Ser Arg Leu His  Leu Ser Gln 
    1850                 1855                 1860             


Phe Asn  Ser Met Ser Ala Leu  His Glu Ile Tyr Ser  Tyr Ile Thr 
    1865                 1870                 1875             


Lys Tyr  Lys Asp Glu Ile Leu  Ala Ala Leu Glu Lys  Asp Glu Gln 
    1880                 1885                 1890             


Ala Arg  Arg Gln Arg Leu Arg  Ser Lys Leu Glu Gln  Val Val Asp 
    1895                 1900                 1905             


Thr Met  Ala Leu Ser Ser 
    1910                 


<210>  123
<211>  457
<212>  DNA
<213>  Homo sapiens

<400>  123
atgttcccca ggccaggggc attgtcctgg acagtcagga ggcatacccc tcgccaggtg       60

gaaccaccct gtgtatgcat gaccctgaca agcaggcgcc aggacagtca ggaggccagg      120

cccgagtgcc aggcatggac ggggacgctg ctgctgggca catgccttct gtactgcgcc      180

cgctccagca tgcccatctg caccgtctcc atgagccagg acttcggctg gaacaagaag      240

gaggccggca tcgtgctcag cagcttcttc tggggctact gcctgacaca ggttgtgggc      300

ggccacctcg gggatcggat tgggggtgag aaggtcatcc tgctgtcagc ctctgcctgg      360

ggctccatca cggccgtcac cccactgctc gcccacctga gcagtgccca cctggccttc      420

atgaccttct cacgcatcct catgggcttg ctccaag                               457


<210>  124
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Phe Pro Arg Pro Gly Ala Leu Ser Trp Thr Val Arg Arg His Thr 
1               5                   10                  15      


Pro Arg Gln Val Glu Pro Pro Cys Val Cys Met Thr Leu Thr Ser Arg 
            20                  25                  30          


Arg Gln Asp Ser Gln Glu Ala Arg Pro Glu Cys Gln Ala Trp Thr Gly 
        35                  40                  45              


Thr Leu Leu Leu Gly Thr Cys Leu Leu Tyr Cys Ala Arg Ser Ser Met 
    50                  55                  60                  


Pro Ile Cys Thr Val Ser Met Ser Gln Asp Phe Gly Trp Asn Lys Lys 
65                  70                  75                  80  


Glu Ala Gly Ile Val Leu Ser Ser Phe Phe Trp Gly Tyr Cys Leu Thr 
                85                  90                  95      


Gln Val Val Gly Gly His Leu Gly Asp Arg Ile Gly Gly Glu Lys Val 
            100                 105                 110         


Ile Leu Leu Ser Ala Ser Ala Trp Gly Ser Ile Thr Ala Val Thr Pro 
        115                 120                 125             


Leu Leu Ala His Leu Ser Ser Ala His Leu Ala Phe Met Thr Phe Ser 
    130                 135                 140                 


Arg Ile Leu Met Gly Leu Leu Gln 
145                 150         


<210>  125
<211>  1185
<212>  DNA
<213>  Homo sapiens

<400>  125
atggccgggg ccgccatggc cgagcggggc cgcgtgcctc cccccgcacc cgcgcccagc       60

acggaggggc tgccgcgcgc cttcctgcag agcctgcgca ccctgttcga catcctggac      120

gaccggcggc gcggctgcgt gcacctgcgc gagatcgagt cccgctggca gggcaccgac      180

gcgcgggagc tgccccgcgg ggtgctggag ggcttgcgcc aggtggcccc ggccagcggc      240

tacctgacct tcgagcgctt cgtggccggc ctgcgcacct ccctgctgag cgccgacggc      300

ggcccccggg accccacgcg cgccccggcc cggcccgggg atcagccgcc gccgccgccg      360

cagcgcctgg tgttcgctcc ggccgacgag ccgcggacgg tcctggagag gaagcccctg      420

cccctgggcg tgcgcgcccc tctggccggt cccagcgccg ccgcccgcag cccggagcag      480

ctgtgcgccc cggctgaggc ggcgccctgc cccgcggagc ccgagcggtc ccagagcgcg      540

gcgctggaac cgagctccag cgcggacgca ggtgcagtgg cgtgcagggc cctggaggcg      600

gactcagggg atgcccggcg ggctccccgt gcccgagggg aacgtcggag gcacaccatc      660

gccagcggcg tggactgcgg cctgctgaag cagatgaagg agctggagca ggagaaggag      720

gtgctgctgc agggtttgga gatgatggcg cggggccgcg actggtacca gcagcagctg      780

caacgagtgc aggagcgcca gcgccgcctg ggccagagca gagccagcgc cgactttggg      840

gctgcaggga gcccccgccc actggggcgg ctactgccca aggtacaaga ggtggcccgg      900

tgcctggggg agctgctggc tgcagcctgt gccagccggg ccctgccccc gtcctcctcc      960

gggcccccct gccctgccct gacgtccacc tcacccccgg tctggcagca gcagaccatc     1020

ctcatgctga aggagcagaa ccgactcctc acccaggagg tgaccgagaa gagtgagcgc     1080

atcacgcagc tggagcagga gaagtcggcg ctcattaagc agctgtttga ggcccgcgcc     1140

ctgagccagc aggacggggg acctctggat tccaccttca tctag                     1185


<210>  126
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Gly Ala Ala Met Ala Glu Arg Gly Arg Val Pro Pro Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ser Thr Glu Gly Leu Pro Arg Ala Phe Leu Gln Ser Leu 
            20                  25                  30          


Arg Thr Leu Phe Asp Ile Leu Asp Asp Arg Arg Arg Gly Cys Val His 
        35                  40                  45              


Leu Arg Glu Ile Glu Ser Arg Trp Gln Gly Thr Asp Ala Arg Glu Leu 
    50                  55                  60                  


Pro Arg Gly Val Leu Glu Gly Leu Arg Gln Val Ala Pro Ala Ser Gly 
65                  70                  75                  80  


Tyr Leu Thr Phe Glu Arg Phe Val Ala Gly Leu Arg Thr Ser Leu Leu 
                85                  90                  95      


Ser Ala Asp Gly Gly Pro Arg Asp Pro Thr Arg Ala Pro Ala Arg Pro 
            100                 105                 110         


Gly Asp Gln Pro Pro Pro Pro Pro Gln Arg Leu Val Phe Ala Pro Ala 
        115                 120                 125             


Asp Glu Pro Arg Thr Val Leu Glu Arg Lys Pro Leu Pro Leu Gly Val 
    130                 135                 140                 


Arg Ala Pro Leu Ala Gly Pro Ser Ala Ala Ala Arg Ser Pro Glu Gln 
145                 150                 155                 160 


Leu Cys Ala Pro Ala Glu Ala Ala Pro Cys Pro Ala Glu Pro Glu Arg 
                165                 170                 175     


Ser Gln Ser Ala Ala Leu Glu Pro Ser Ser Ser Ala Asp Ala Gly Ala 
            180                 185                 190         


Val Ala Cys Arg Ala Leu Glu Ala Asp Ser Gly Asp Ala Arg Arg Ala 
        195                 200                 205             


Pro Arg Ala Arg Gly Glu Arg Arg Arg His Thr Ile Ala Ser Gly Val 
    210                 215                 220                 


Asp Cys Gly Leu Leu Lys Gln Met Lys Glu Leu Glu Gln Glu Lys Glu 
225                 230                 235                 240 


Val Leu Leu Gln Gly Leu Glu Met Met Ala Arg Gly Arg Asp Trp Tyr 
                245                 250                 255     


Gln Gln Gln Leu Gln Arg Val Gln Glu Arg Gln Arg Arg Leu Gly Gln 
            260                 265                 270         


Ser Arg Ala Ser Ala Asp Phe Gly Ala Ala Gly Ser Pro Arg Pro Leu 
        275                 280                 285             


Gly Arg Leu Leu Pro Lys Val Gln Glu Val Ala Arg Cys Leu Gly Glu 
    290                 295                 300                 


Leu Leu Ala Ala Ala Cys Ala Ser Arg Ala Leu Pro Pro Ser Ser Ser 
305                 310                 315                 320 


Gly Pro Pro Cys Pro Ala Leu Thr Ser Thr Ser Pro Pro Val Trp Gln 
                325                 330                 335     


Gln Gln Thr Ile Leu Met Leu Lys Glu Gln Asn Arg Leu Leu Thr Gln 
            340                 345                 350         


Glu Val Thr Glu Lys Ser Glu Arg Ile Thr Gln Leu Glu Gln Glu Lys 
        355                 360                 365             


Ser Ala Leu Ile Lys Gln Leu Phe Glu Ala Arg Ala Leu Ser Gln Gln 
    370                 375                 380                 


Asp Gly Gly Pro Leu Asp Ser Thr Phe Ile 
385                 390                 


<210>  127
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  127
atgggcctca gcccagggca gacctcagtg tccttcctgt ggccgctgct ggaggtgcgt       60

gaccacaaca cagggagggg actcgtcccc gccactgtgc tgacgcctgg gtctccagag      120

accctcctgg aactccgcca ggccttcctg ggttccagac aggcccgcca cgggcatgac      180

gcagcgccat ctagcggaca gcagggctgc agcgtggaca gaacggccgg acgcccagtc      240

ctgggctggc ggctgaggaa cagcctcaca gggcaagagg gcaggcaaca cctgcatctt      300

tccggcataa gaacctcaag aaaagcaaag gaatataagc ctgtgttctt tggagccacc      360

gaaatctctg ttctcatggc agtcgctgaa agtttaaggg agccgccacc gccccaatgg      420

ggttggtttc tttcttccct gtttttaaag atcttttaa                             459


<210>  128
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gly Leu Ser Pro Gly Gln Thr Ser Val Ser Phe Leu Trp Pro Leu 
1               5                   10                  15      


Leu Glu Val Arg Asp His Asn Thr Gly Arg Gly Leu Val Pro Ala Thr 
            20                  25                  30          


Val Leu Thr Pro Gly Ser Pro Glu Thr Leu Leu Glu Leu Arg Gln Ala 
        35                  40                  45              


Phe Leu Gly Ser Arg Gln Ala Arg His Gly His Asp Ala Ala Pro Ser 
    50                  55                  60                  


Ser Gly Gln Gln Gly Cys Ser Val Asp Arg Thr Ala Gly Arg Pro Val 
65                  70                  75                  80  


Leu Gly Trp Arg Leu Arg Asn Ser Leu Thr Gly Gln Glu Gly Arg Gln 
                85                  90                  95      


His Leu His Leu Ser Gly Ile Arg Thr Ser Arg Lys Ala Lys Glu Tyr 
            100                 105                 110         


Lys Pro Val Phe Phe Gly Ala Thr Glu Ile Ser Val Leu Met Ala Val 
        115                 120                 125             


Ala Glu Ser Leu Arg Glu Pro Pro Pro Pro Gln Trp Gly Trp Phe Leu 
    130                 135                 140                 


Ser Ser Leu Phe Leu Lys Ile Phe 
145                 150         


<210>  129
<211>  1446
<212>  DNA
<213>  Homo sapiens

<400>  129
atgggggcct tggccagagc cctgccgtcc atactgctgg cattgctgct tacgtccacc       60

ccagaggctc tgggtgccaa ccccggcttg gtcgccagga tcaccgacaa gggactgcag      120

tatgcggccc aggaggggct attggctctg cagagtgagc tgctcaggat cacgctgcct      180

gacttcaccg gggacttgag gatcccccac gtcggccgtg ggcgctatga gttccacagc      240

ctgaacatcc acagctgtga gctgcttcac tctgcgctga ggcctgtccc tggccagggc      300

ctgagtctca gcatctccga ctcctccatc cgggtccagg gcaggtggaa ggtgcgcaag      360

tcattcttca aactacaggg ctcctttgat gtcagtgtca agggcatcag catttcggtc      420

aacctcctgt tgggcagcga gtcctccggg aggcccacag ttactgcctc cagctgcagc      480

agtgacatcg ctgacgtgga ggtggacatg tcgggagact tggggtggct gttgaacctc      540

ttccacaacc agattgagtc caagttccag aaagtactgg agagcaggat ttgcgaaatg      600

atccagaaat cggtgtcctc cgatctacag ccttatctcc aaactctgcc agttacaaca      660

gagattgaca gtttcgccga cattgattat agcttagtgg aagcccctcg ggcaacagcc      720

cagatgctgg aggtgatgtt taagggtgaa atctttcatc gtaaccaccg ttctccagtt      780

accctccttg ctgcagtcat gagccttcct gaggaacaca acaaaatggt ctactttgcc      840

atctcggatt atgtcttcaa cacggccagc ctggtttatc atgaggaagg atatctgaac      900

ttctccatca cagatgacat gataccgcct gactctaata tccgactgac caccaagtcc      960

ttccgaccct tcgtcccacg gttagccagg ctctacccca acatgaacct ggaactccag     1020

ggatcagtgc cctctgctcc gctcctgaac ttcagccctg ggaatctgtc tgtggacccc     1080

tatatggaga tagatgcctt tgtgctcctg cccagctcca gcaaggagcc tgtcttccgg     1140

ctcagtgtgg ccactaatgt gtccgccacc ttgaccttca ataccagcaa gatcactggg     1200

ttcctgaagc caggaaaggt aaaagtggaa ctgaaagaat ccaaagttgg actattcaat     1260

gcagagctgt tggaagcgct cctcaactat tacatcctta acaccttcta ccccaagttc     1320

aatgataagt tggccgaagg cttccccctt cctctgctga agcgtgttca gctctacgac     1380

cttgggctgc agatccataa ggacttcctg ttcttgggtg ccaatgtcca atacatgaga     1440

gtttga                                                                1446


<210>  130
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala 
            20                  25                  30          


Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu 
        35                  40                  45              


Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly 
    50                  55                  60                  


Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser 
65                  70                  75                  80  


Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val 
                85                  90                  95      


Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val 
            100                 105                 110         


Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser 
        115                 120                 125             


Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu 
    130                 135                 140                 


Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser 
145                 150                 155                 160 


Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp 
                165                 170                 175     


Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val 
            180                 185                 190         


Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp 
        195                 200                 205             


Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser 
    210                 215                 220                 


Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala 
225                 230                 235                 240 


Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His 
                245                 250                 255     


Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu 
            260                 265                 270         


His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr 
        275                 280                 285             


Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr 
    290                 295                 300                 


Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser 
305                 310                 315                 320 


Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn 
                325                 330                 335     


Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser 
            340                 345                 350         


Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val 
        355                 360                 365             


Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala 
    370                 375                 380                 


Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val 
                405                 410                 415     


Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile 
            420                 425                 430         


Leu Asn Thr Phe Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe 
        435                 440                 445             


Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln 
    450                 455                 460                 


Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg 
465                 470                 475                 480 


Val 
    


<210>  131
<211>  3081
<212>  DNA
<213>  Homo sapiens

<400>  131
atggtctgtc gcccagtgtt cccttgtcgt cggcgatttt gcccccgacc cttcttggtg       60

ggcttagtgg tggcaatctg tctcttctac cagactctga ccctccgagg gtcgaggaag      120

ctcacagccg ctgcccctgg ggctgtccca cacacatcca ctgaaaccca ggcaagcaga      180

tgcaagaaag gattctctca ggacaaacag tgcttccttc tctctggtaa tgcccaggaa      240

accagaaagg tcaaagaatc aatggagaca cactttggca gccatggccg aagggccata      300

ctctacaggc ctcctttcta cagcaaaaca gagcttcagc tacaccagca cattctgact      360

caacatggct atacggttgt catcgctgaa gaaaggctca atgctggcct agggccgggg      420

ctactagaac aaggtgatct gggctcttgg gatctgctca tttgcctgtc ttctaagaaa      480

gcagaaggaa caccctgtat atccaaggaa gtcatgtgcc agttaggttt acatcaaaag      540

gcaaacagat taccagaaat acagcagcca ctttgcagaa aggaaggatt atgtcaaata      600

gttagaagat tcccagaact gcaacttcca gtgagtccct ctgtgtgtct ggatcaggga      660

atgcaattaa agccgagtac ttcgagtcac cttttaaaaa cagtgaagcc acgtgtgtgg      720

aaaccagggg actggagtcg tgaacagctg aatgaaacga cagtccttgc tccacatgaa      780

acaatctttc gagccgaaga tctatctgtg attcttaaag cgtatgtgtt ggtgacgtcc      840

ttaacccctt tgcgtgcatt cattcattcg acgggcacag tttggaatcc accaaagaaa      900

aaacgcttca ctgtcaagct gcaaacattt tttgagacat tcctgagagc cagttcacct      960

caacaggctt ttgacattat gaaggaagca attggcaaac tactgctagc ggctgaagta     1020

ttcagtgaaa catctactct gggaccaaag accttccata gatgcagatt ctgctttcaa     1080

cttctaactt ttgatattgg ttatggcagt ttcatgtacc ctgtagtgct ccaggtacac     1140

gagcatttaa attttcaaga ttatgataat atggattttg aggaccaaaa tacagaagaa     1200

ttccttttaa atgacacttt caattttctc ttccctaatg aatcatcact ttccatattt     1260

tctgagatat ttcagagact ttatagatca gatgttttca agggtgaaaa ctatcaaaag     1320

gaactaaatc agtgtctgtc cttagaagaa attaactcaa ttatgacttt cataaaggaa     1380

cttggaagtc tgggacaatt ccaactgctc ttcccatcta ctactcctgg gattcagtca     1440

ctgatgcatg aattttatga tgtggcaaat cctgtgggaa atcctggctc agtcctgacc     1500

caatactggt ctcttttaaa tgtatttgaa caatttcagt tcatgaataa aaagacacag     1560

ccacatccac tggaatggaa ttctttcaca gaagataaga acattgaaaa accacaagtg     1620

ccatttgatg caatagaaaa taaaaaagct gcagttccac aaattaaaaa tgaaaataaa     1680

gaaatacatt gcagtgatga tgaaaacaca ccatgtcata tcaagcagat cttcacacat     1740

ccacatttgg aactaaatcc tgactttcat ccaaagatca aagattatta ctgtgaagtc     1800

ccatttgatg tggtaacagt gacaattgga gtggaaactc ctaagtgtct gtgcaaggtg     1860

cacctgtacg agcaggcagg gccaagcttt gccagctacc ctctgggctt aggaatgaac     1920

aaaatctcaa tatttgttgt ggatgaatct ccagcacacg gtgagactct gatcacgtac     1980

aaactcacca tctatagaga agaccgccca agtctgccct tgtttgaggc cttcacagca     2040

tgtggttttg tgcaggattg tggtttgctg attcatccag aggaaacctg tgggttacag     2100

cctatttctt ctgactacat tgaagccatt ttacagtctg aactaaaaag atgtccatct     2160

ggggacatga aaggccagtg gattgtgcct tgccttagtt gttcggacaa caggacgtgt     2220

gactggagag aaataacctg gcagccccac aactgccaat atggtgtcct aactaagcct     2280

caactccagc agtgcctggg aggaaggaag attctgttca ttggagattc aaccaacaga     2340

gggatcatgt actatcttat tgaaaggctg aatgaaacgt tgcaggaatg gcagaaagta     2400

catggcacta aattctatca caacgtcaat ggtgggaaga ctttgatcag ttattcctac     2460

tatccccagt tctggataag cccttcattg agaccaacat ttgaaaatgc acttgaacac     2520

ctcttgcaaa gatcacgtcc cctagagaat actggccaga ctgtattggt tgttggtggt     2580

gttcagtggc ttaattccaa tcacctgcaa attattcaca aagttttgaa gagggaaaat     2640

ttactcaata tcctagtgat catcaaaact ttgggaattg gatttcatct gccagtggat     2700

ggagtacatt tcttaacaca gagtgaagta cagaacttat ggaaagaaaa tttgattatt     2760

ctggatactg caaaaaaaca tggctatgaa gtagttgaca cattcactat aacaatgggg     2820

cgttacaaag agtttctaca ggggaagtgt ggatgtcatt tccatgaggt agtgaaatca     2880

aagttatcca aagaatataa ctttattaaa atgaaaagat caagaaatca tatcatggga     2940

agatatttca gcaatcaaag caaactacaa caaggcactg taacaaattt tcgatcgcca     3000

tatcatgtca gaggtccaat aaatcaggtt tgttctgaaa tccttctcag caggatgtgt     3060

gcaaataaaa ggactatgta g                                               3081


<210>  132
<211>  1026
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Val Cys Arg Pro Val Phe Pro Cys Arg Arg Arg Phe Cys Pro Arg 
1               5                   10                  15      


Pro Phe Leu Val Gly Leu Val Val Ala Ile Cys Leu Phe Tyr Gln Thr 
            20                  25                  30          


Leu Thr Leu Arg Gly Ser Arg Lys Leu Thr Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Val Pro His Thr Ser Thr Glu Thr Gln Ala Ser Arg Cys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Gln Asp Lys Gln Cys Phe Leu Leu Ser Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Glu Ser Met Glu Thr His Phe Gly Ser His Gly 
                85                  90                  95      


Arg Arg Ala Ile Leu Tyr Arg Pro Pro Phe Tyr Ser Lys Thr Glu Leu 
            100                 105                 110         


Gln Leu His Gln His Ile Leu Thr Gln His Gly Tyr Thr Val Val Ile 
        115                 120                 125             


Ala Glu Glu Arg Leu Asn Ala Gly Leu Gly Pro Gly Leu Leu Glu Gln 
    130                 135                 140                 


Gly Asp Leu Gly Ser Trp Asp Leu Leu Ile Cys Leu Ser Ser Lys Lys 
145                 150                 155                 160 


Ala Glu Gly Thr Pro Cys Ile Ser Lys Glu Val Met Cys Gln Leu Gly 
                165                 170                 175     


Leu His Gln Lys Ala Asn Arg Leu Pro Glu Ile Gln Gln Pro Leu Cys 
            180                 185                 190         


Arg Lys Glu Gly Leu Cys Gln Ile Val Arg Arg Phe Pro Glu Leu Gln 
        195                 200                 205             


Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gln Gly Met Gln Leu Lys 
    210                 215                 220                 


Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val Lys Pro Arg Val Trp 
225                 230                 235                 240 


Lys Pro Gly Asp Trp Ser Arg Glu Gln Leu Asn Glu Thr Thr Val Leu 
                245                 250                 255     


Ala Pro His Glu Thr Ile Phe Arg Ala Glu Asp Leu Ser Val Ile Leu 
            260                 265                 270         


Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro Leu Arg Ala Phe Ile 
        275                 280                 285             


His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys Lys Lys Arg Phe Thr 
    290                 295                 300                 


Val Lys Leu Gln Thr Phe Phe Glu Thr Phe Leu Arg Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gln Ala Phe Asp Ile Met Lys Glu Ala Ile Gly Lys Leu Leu Leu 
                325                 330                 335     


Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu Gly Pro Lys Thr Phe 
            340                 345                 350         


His Arg Cys Arg Phe Cys Phe Gln Leu Leu Thr Phe Asp Ile Gly Tyr 
        355                 360                 365             


Gly Ser Phe Met Tyr Pro Val Val Leu Gln Val His Glu His Leu Asn 
    370                 375                 380                 


Phe Gln Asp Tyr Asp Asn Met Asp Phe Glu Asp Gln Asn Thr Glu Glu 
385                 390                 395                 400 


Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe Pro Asn Glu Ser Ser 
                405                 410                 415     


Leu Ser Ile Phe Ser Glu Ile Phe Gln Arg Leu Tyr Arg Ser Asp Val 
            420                 425                 430         


Phe Lys Gly Glu Asn Tyr Gln Lys Glu Leu Asn Gln Cys Leu Ser Leu 
        435                 440                 445             


Glu Glu Ile Asn Ser Ile Met Thr Phe Ile Lys Glu Leu Gly Ser Leu 
    450                 455                 460                 


Gly Gln Phe Gln Leu Leu Phe Pro Ser Thr Thr Pro Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro Val Gly Asn Pro Gly 
                485                 490                 495     


Ser Val Leu Thr Gln Tyr Trp Ser Leu Leu Asn Val Phe Glu Gln Phe 
            500                 505                 510         


Gln Phe Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser 
        515                 520                 525             


Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala 
    530                 535                 540                 


Ile Glu Asn Lys Lys Ala Ala Val Pro Gln Ile Lys Asn Glu Asn Lys 
545                 550                 555                 560 


Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln 
                565                 570                 575     


Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys 
            580                 585                 590         


Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr 
        595                 600                 605             


Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu 
    610                 615                 620                 


Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn 
625                 630                 635                 640 


Lys Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr 
                645                 650                 655     


Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu 
            660                 665                 670         


Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly 
        675                 680                 685             


Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser 
    690                 695                 700                 


Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser 
705                 710                 715                 720 


Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp 
                725                 730                 735     


Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys 
            740                 745                 750         


Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly 
        755                 760                 765             


Arg Lys Ile Leu Phe Ile Gly Asp Ser Thr Asn Arg Gly Ile Met Tyr 
    770                 775                 780                 


Tyr Leu Ile Glu Arg Leu Asn Glu Thr Leu Gln Glu Trp Gln Lys Val 
785                 790                 795                 800 


His Gly Thr Lys Phe Tyr His Asn Val Asn Gly Gly Lys Thr Leu Ile 
                805                 810                 815     


Ser Tyr Ser Tyr Tyr Pro Gln Phe Trp Ile Ser Pro Ser Leu Arg Pro 
            820                 825                 830         


Thr Phe Glu Asn Ala Leu Glu His Leu Leu Gln Arg Ser Arg Pro Leu 
        835                 840                 845             


Glu Asn Thr Gly Gln Thr Val Leu Val Val Gly Gly Val Gln Trp Leu 
    850                 855                 860                 


Asn Ser Asn His Leu Gln Ile Ile His Lys Val Leu Lys Arg Glu Asn 
865                 870                 875                 880 


Leu Leu Asn Ile Leu Val Ile Ile Lys Thr Leu Gly Ile Gly Phe His 
                885                 890                 895     


Leu Pro Val Asp Gly Val His Phe Leu Thr Gln Ser Glu Val Gln Asn 
            900                 905                 910         


Leu Trp Lys Glu Asn Leu Ile Ile Leu Asp Thr Ala Lys Lys His Gly 
        915                 920                 925             


Tyr Glu Val Val Asp Thr Phe Thr Ile Thr Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Phe Leu Gln Gly Lys Cys Gly Cys His Phe His Glu Val Val Lys Ser 
945                 950                 955                 960 


Lys Leu Ser Lys Glu Tyr Asn Phe Ile Lys Met Lys Arg Ser Arg Asn 
                965                 970                 975     


His Ile Met Gly Arg Tyr Phe Ser Asn Gln Ser Lys Leu Gln Gln Gly 
            980                 985                 990         


Thr Val Thr Asn Phe Arg Ser Pro  Tyr His Val Arg Gly  Pro Ile Asn 
        995                 1000                 1005             


Gln Val  Cys Ser Glu Ile Leu  Leu Ser Arg Met Cys  Ala Asn Lys 
    1010                 1015                 1020             


Arg Thr  Met 
    1025     


<210>  133
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  133
atgtcgctca cggtcgtcag catggcgtgc gttgggttct tcttgctgca gggggcctgg       60

ccactcatgg gtggtcagga caaacccttc ctgtctgccc ggcccagcac tgtggtgcct      120

cgaggaggac acgtggctct tcagtgtcac tatcgtcgtg ggtttaacaa tttcatgctg      180

tacaaagaag acagaagcca cgttcccatc ttccacggca gaatattcca ggagagcttc      240

atcatgggcc ctgtgacccc agcacatgca gggacctaca gatgtcgggg ttcacgccca      300

cactccctca ctgggtggtc ggcacccagc aaccccctgg tgatcatggt cacaggaaac      360

cacagaaaac cttccctcct ggcccaccca gggcccctgc tgaaatcagg agagacagtc      420

atcctgcaat gttggtcaga tgtcatgttt gagcacttct ttctgcacag agaggggatc      480

tctgaggacc cctcacgcct cgttggacag atccatgatg gggtctccaa ggccaacttc      540

tccatcggtc ccttgatgcc tgtccttgca ggaacctaca gatgttatgg ttctgttcct      600

cactccccct atcagttgtc agctcccagt gaccccctgg acatcgtgat cacaggtcta      660

tatgagaaac cttctctctc agcccagccg ggccccacgg ttcaggcagg agagaacgtg      720

accttgtcct gtagctcctg gagctcctat gacatctacc atctgtccag ggaaggggag      780

gcccatgaac gtaggctccg tgcagtgccc aaggtcaaca gaacattcca ggcagacttt      840

cctctgggcc ctgccaccca cggagggacc tacagatgct tcggctcttt ccgtgccctg      900

ccctgcgtgt ggtcaaactc aagtgaccca ctgcttgttt ctgtcacagg aaacccttca      960

agtagttggc cttcacccac agaaccaagc tccaaatctg gtatctgcag acacctgcat     1020

gttctgattg ggacctcagt ggtcatcttc ctcttcatcc tcctcctctt ctttctcctt     1080

tatcgctggt gctccaacaa aaagaatgct gctgtaatgg accaagagcc tgcgggggac     1140

agaacagtga ataggcagga ctctgatgaa caagaccctc aggaggtgac gtacgcacag     1200

ttggatcact gcgttttcat acagagaaaa atcagtcgcc cttctcagag gcccaagaca     1260

cccctaacag ataccagcgt gtacacggaa cttccaaatg ctgagcccag atccaaagtt     1320

gtctcctgcc cacgagcacc acagtcaggt cttgaggggg ttttctag                  1368


<210>  134
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  135
<211>  3957
<212>  DNA
<213>  Homo sapiens

<400>  135
atgtctggcg gggccagtgc cacaggccca aggagagggc ccccaggact ggaggacacc       60

actagtaaga agaagcagaa ggatcgagca aaccaggaga gcaaggatgg agatcctagg      120

aaagagacag ggtctcgata tgttgcccag gctggtcttg aacctctggc ctcaggtgat      180

ccttctgcct cagcctccca tgcagctggg atcacaggct cacgccaccg tacccggctg      240

ttctttcctt catcgtcagg gtcagcatcc actcctcaag aggagcagac caaagaggga      300

gcttgtgaag accctcatga tctcttggct actcccactc cagagttgtt gctcgattgg      360

aggcagagtg cagaagaggt gattgtcaag cttcgtgtgg gagtaggtcc cctgcagctg      420

gaggatgtag atgctgcttt cacagataca gactgtgtgg tgcggtttgc aggtggtcag      480

cagtggggtg gtgtcttcta tgctgagata aaaagctctt gtgctaaagt gcaaacccgc      540

aagggcagtc tcctgcacct gacactgccc aaaaaggtgc ctatgctcac gtggccctcc      600

ctcctggttg aggctgatga acagctttgc ataccaccgc tgaactccca aacctgcctc      660

ctgggctcag aggagaattt agcccctttg gcaggagaga aagcagtgcc tcccgggaat      720

gacccagtct ctccagccat ggtccggagc agaaaccctg ggaaagatga ctgtgccaag      780

gaggagatgg cagtggcagc agatgctgca accttggtgg atgagcccga gtcgatggtg      840

aacctggcgt ttgtcaagaa tgactcgtat gagaagggcc cggattcagt ggtggtgcac      900

gtgtacgtga aggagatctg cagggacacc tcaagagtac ttttccgtga gcaggacttc      960

acgctcatct tccagaccag ggatggaaac ttcctgaggc tgcacccggg ctgtgggccc     1020

cacaccacct tccgttggca ggtgaagctc aggaatctga ttgagccaga gcagtgcacc     1080

ttctgtttca cggcttctcg catcgacatc tgccttcgta agaggcagag tcagcgctgg     1140

gggggcctgg aggccccggc tgcacgagtg ggtggtgcaa aggttgccgt gccgacaggt     1200

ccaacccctc tggattcaac cccaccagga ggtgctcccc accccctgac aggccaggag     1260

gaggcccggg ctgtggagaa ggataaatcc aaggcacgat ctgaggacac agggctagac     1320

agtgtggcaa cccgcacacc catggagcat gtaaccccaa agccagagac acacctggcc     1380

tcgcccaagc ctacatgcat ggtgcctccc atgccccaca gcccagttag tggagacagc     1440

gtggaggagg aggaagagga agagaagaag gtgtgtctgc caggcttcac tggccttgtc     1500

aatttaggca acacctgctt catgaacagc gtcattcagt ctctgtccaa cactcgggaa     1560

ctccgggact tcttccatga ccgctccttt gaggctgaga tcaactacaa caacccacta     1620

gggactggtg ggcgtctggc cattggcttt gccgtgctgc ttcgggcgct gtggaagggc     1680

acccaccatg ccttccagcc ttccaagttg aaggccattg tggcgagtaa ggccagccag     1740

ttcacaggct atgcacagca tgatgcccag gagttcatgg ctttcctgct ggatgggctg     1800

cacgaggacc tgaatcgcat tcagaacaag ccctacacag agaccgtgga ttcagatggg     1860

cggcccgatg aggtggtagc tgaggaagca tggcagcggc acaagatgag gaatgactct     1920

ttcatcgtgg acctatttca ggggcagtac aagtcgaagc tggtgtgccc tgtgtgtgcc     1980

aaggtctcca tcacttttga cccgtttctt tatctgccgg tgcccttgcc acaaaagcaa     2040

aaggttctcc ctgtctttta ttttgcccga gagccccaca gcaagcccat caagttcctg     2100

gtgagcgtca gcaaggagaa ctccactgcg agcgaagtat tggactccct ctctcagagt     2160

gttcatgtga agcctgagaa cctgcgtttg gcggaggtaa ttaagaatcg ttttcatcgt     2220

gtgttcctac cctcccactc actggacact gtgtccccat ctgatacgct cctctgcttt     2280

gagctgctat cctcagagtt ggctaaggag cgggtagtgg tgctagaggt gcaacagcgc     2340

ccccaggtgc ccagcgtccc catctccaag tgtgcagcct gccagcggaa gcaacagtcg     2400

gaggatgaaa agctgaagcg ctgtacccgg tgctaccgtg tgggctactg caaccagctc     2460

tgccagaaaa cccactggcc tgaccacaag ggcctctgcc gacctgagaa cattggctac     2520

cccttcctgg tcagtgtacc tgcctcacgc ctcacttatg cccgcctcgc tcagttgcta     2580

gagggctatg cccggtactc tgtgagtgta ttccagccac cctttcagcc aggccgcatg     2640

gccttggagt ctcagagccc tggctgcacc acactgctct ccacaggttc cctggaggct     2700

ggggacagcg agagagaccc cattcagcca cctgagctcc agctggtgac ccctatggct     2760

gagggggaca cagggcttcc ccgggtgtgg gcagcccctg accggggtcc tgtgcccagc     2820

accagtggaa tttcttctga gatgctggcc agtgggccca ttgaggttgg ctccttgcca     2880

gctggcgaga gggtgtcccg acccgaagct gctgtgcctg ggtaccagca tccaagtgaa     2940

gctatgaatg cccacacacc ccagttcttc atctataaaa ttgattcatc caaccgagag     3000

cagcggctag aggacaaagg agacacccca ctggagctgg gtgacgactg tagcctggct     3060

ctcgtctggc ggaacaatga gcgcttgcag gagtttgtgt tggtagcctc caaggagctg     3120

gaatgtgctg aggatccagg ctctgccggt gaggctgccc gggccggcca cttcaccctg     3180

gaccagtgcc tcaacctctt cacacggcct gaggtgctgg cacccgagga ggcctggtac     3240

tgcccacagt gcaaacagca ccgtgaggcc tccaagcagc tgttgctatg gcgcctgcca     3300

aatgttctca tcgtgcagct caagcgcttc tcctttcgta gttttatctg gcgtgacaag     3360

atcaatgact tggtggagtt ccctgttagg aacctggacc tgagcaagtt ctgcattggt     3420

cagaaagagg agcagctgcc cagctacgat ctatatgctg tcatcaacca ctatggaggc     3480

atgattggtg gccactacac tgcctgtgca cgcctgccca atgatcgtag cagtcagcgc     3540

agtgacgtgg gctggcgctt gtttgatgac agcacagtga caacggtaga cgagagccag     3600

gttgtgacgc gttatgccta tgtactcttc taccgccggc ggaactctcc tgtggagagg     3660

ccccccaggg caggtcactc tgagcaccac ccagacctag gccctgcagc tgaggctgct     3720

gccagccagg cttcccggat ttggcaggag ctggaggctg aggaggagcc ggtgcctgag     3780

gggtctgggc ccctgggtcc ctgggggccc caagactggg tgggccccct accacgtggc     3840

cctaccacac cagatgaggg ctgcctccgg tactttgtcc tgggcaccgt ggcggctttg     3900

gtggccctcg tgctcaacgt gttctatcct ctggtatccc agagtcgctg gagatga        3957


<210>  136
<211>  1318
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly 
1               5                   10                  15      


Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln 
            20                  25                  30          


Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val 
        35                  40                  45              


Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser 
    50                  55                  60                  


Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu 
65                  70                  75                  80  


Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln 
                85                  90                  95      


Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro 
            100                 105                 110         


Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile 
        115                 120                 125             


Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp 
    130                 135                 140                 


Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln 
145                 150                 155                 160 


Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys 
                165                 170                 175     


Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys 
            180                 185                 190         


Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln 
        195                 200                 205             


Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu 
    210                 215                 220                 


Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn 
225                 230                 235                 240 


Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp 
                245                 250                 255     


Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu 
            260                 265                 270         


Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp 
        275                 280                 285             


Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys 
    290                 295                 300                 


Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe 
305                 310                 315                 320 


Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro 
                325                 330                 335     


Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn 
            340                 345                 350         


Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile 
        355                 360                 365             


Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu 
    370                 375                 380                 


Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly 
385                 390                 395                 400 


Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu 
                405                 410                 415     


Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala 
            420                 425                 430         


Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met 
        435                 440                 445             


Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro 
    450                 455                 460                 


Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser 
465                 470                 475                 480 


Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe 
                485                 490                 495     


Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile 
            500                 505                 510         


Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg 
        515                 520                 525             


Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly 
    530                 535                 540                 


Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly 
545                 550                 555                 560 


Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser 
                565                 570                 575     


Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe 
            580                 585                 590         


Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln 
        595                 600                 605             


Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu 
    610                 615                 620                 


Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser 
625                 630                 635                 640 


Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys 
                645                 650                 655     


Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu 
            660                 665                 670         


Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe 
        675                 680                 685             


Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser 
    690                 695                 700                 


Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn 
                725                 730                 735     


Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser 
            740                 745                 750         


Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala 
        755                 760                 765             


Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro 
    770                 775                 780                 


Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser 
785                 790                 795                 800 


Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr 
                805                 810                 815     


Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu 
            820                 825                 830         


Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala 
        835                 840                 845             


Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala 
    850                 855                 860                 


Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met 
865                 870                 875                 880 


Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly 
                885                 890                 895     


Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu 
            900                 905                 910         


Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg 
        915                 920                 925             


Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile 
    930                 935                 940                 


Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro 
945                 950                 955                 960 


Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln 
                965                 970                 975     


His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr 
            980                 985                 990         


Lys Ile Asp Ser Ser Asn Arg Glu  Gln Arg Leu Glu Asp  Lys Gly Asp 
        995                 1000                 1005             


Thr Pro  Leu Glu Leu Gly Asp  Asp Cys Ser Leu Ala  Leu Val Trp 
    1010                 1015                 1020             


Arg Asn  Asn Glu Arg Leu Gln  Glu Phe Val Leu Val  Ala Ser Lys 
    1025                 1030                 1035             


Glu Leu  Glu Cys Ala Glu Asp  Pro Gly Ser Ala Gly  Glu Ala Ala 
    1040                 1045                 1050             


Arg Ala  Gly His Phe Thr Leu  Asp Gln Cys Leu Asn  Leu Phe Thr 
    1055                 1060                 1065             


Arg Pro  Glu Val Leu Ala Pro  Glu Glu Ala Trp Tyr  Cys Pro Gln 
    1070                 1075                 1080             


Cys Lys  Gln His Arg Glu Ala  Ser Lys Gln Leu Leu  Leu Trp Arg 
    1085                 1090                 1095             


Leu Pro  Asn Val Leu Ile Val  Gln Leu Lys Arg Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Phe  Ile Trp Arg Asp Lys  Ile Asn Asp Leu Val  Glu Phe Pro 
    1115                 1120                 1125             


Val Arg  Asn Leu Asp Leu Ser  Lys Phe Cys Ile Gly  Gln Lys Glu 
    1130                 1135                 1140             


Glu Gln  Leu Pro Ser Tyr Asp  Leu Tyr Ala Val Ile  Asn His Tyr 
    1145                 1150                 1155             


Gly Gly  Met Ile Gly Gly His  Tyr Thr Ala Cys Ala  Arg Leu Pro 
    1160                 1165                 1170             


Asn Asp  Arg Ser Ser Gln Arg  Ser Asp Val Gly Trp  Arg Leu Phe 
    1175                 1180                 1185             


Asp Asp  Ser Thr Val Thr Thr  Val Asp Glu Ser Gln  Val Val Thr 
    1190                 1195                 1200             


Arg Tyr  Ala Tyr Val Leu Phe  Tyr Arg Arg Arg Asn  Ser Pro Val 
    1205                 1210                 1215             


Glu Arg  Pro Pro Arg Ala Gly  His Ser Glu His His  Pro Asp Leu 
    1220                 1225                 1230             


Gly Pro  Ala Ala Glu Ala Ala  Ala Ser Gln Ala Ser  Arg Ile Trp 
    1235                 1240                 1245             


Gln Glu  Leu Glu Ala Glu Glu  Glu Pro Val Pro Glu  Gly Ser Gly 
    1250                 1255                 1260             


Pro Leu  Gly Pro Trp Gly Pro  Gln Asp Trp Val Gly  Pro Leu Pro 
    1265                 1270                 1275             


Arg Gly  Pro Thr Thr Pro Asp  Glu Gly Cys Leu Arg  Tyr Phe Val 
    1280                 1285                 1290             


Leu Gly  Thr Val Ala Ala Leu  Val Ala Leu Val Leu  Asn Val Phe 
    1295                 1300                 1305             


Tyr Pro  Leu Val Ser Gln Ser  Arg Trp Arg 
    1310                 1315             


<210>  137
<211>  3138
<212>  DNA
<213>  Homo sapiens

<400>  137
atggggtcgc agccgccgct ggggtctccg ctgtctcgcg aggagggtga agcgcccccg       60

cctgctcccg cttcggaggg taggcggaga agtcgccggg tacgccttcg cggatcctgc      120

cgacaccgac ctagctttct gggctgccgg gagctcgcgg cgagcgcccc agccaggcct      180

gcgccggcat cctccgagat aatggcatca gctgctaagg aatttaaaat ggacaacttt      240

tcacctaaag ctggcactag caaattgcaa cagacagtac cagctgatgc atctcctgat      300

tctaagtgtc ctatatgctt ggatagattt gataatgtgt cttacttaga tcgctgctta      360

cataagttct gttttcgctg tgtacaggag tggtcaaaaa acaaagctga atgcccacta      420

tgtaaacagc cctttgattc tattttccat tctgtgaggg cagaagatga cttcaaggag      480

tatgtcctaa ggccttcgta taatggttct tttgtcaccc ctgatcgacg atttcgctac      540

cgtacaactc tgacaaggga acgaaatgct tctgtgtatt cacctagtgg tcctgtgaac      600

agaagaacaa caactccacc ggatagtgga gtactgtttg aagggttagg catttcaaca      660

agacctagag atgttgaaat tcctcagttt atgagacaga ttgcagtaag gaggccaact      720

acggcagatg aaagatcttt gcggaaaatt caagaacaag atattattaa ttttagacga      780

actctttatc gtgctggtgc tcgagttaga aatattgaag atggtggccg ctacagggat      840

atttcagctg aatttttccg tagaaatcca gcttgccttc acagattagt cccctggtta      900

aaacgtgaac ttacagttct ttttggagct catggatctt tagtgaatat tgtccagcat      960

attatcatga gtaatgttac tcgctatgac ttggagagtc aggcatttgt gtctgattta     1020

agaccatttt tacttaatcg aactgagcat tttatacatg aatttatcag ttttgcccga     1080

tctcctttta acatggcagc ctttgaccag catgccaatt atgattgccc tgctccttca     1140

tacgaagaag gcagccattc tgattcttca gtcataacaa tatctccaga tgaggctgag     1200

acccaagagc tggatattaa tgtagccact gttagtcagg caccatggga tgatgaaact     1260

ccaggaccat cttactcaag ctcagagcag gtacacgtta ctatgtcttc tcttttaaat     1320

acttctgaca gttcagatga agaacttgtc acaggaggag ccacgtctca gatacaagga     1380

gtacaaacca atgacgacct aaataatgac agtgatgatt cttcagataa ttgtgtcatt     1440

gttgggtttg ttaaaccact agctgagagg accccagaac ttgttgaact gtcctctgat     1500

tctgaggact taggttctta tgagaaaatg gagacagtga agacacaaga acaggagcaa     1560

tcttacagtt ctggtgatag cgatgttagt agatgctcat ctccacactc tgtccttgga     1620

aaggatgaac aaataaataa aggtcattgt gattctagta caagaatcaa atcaaagaag     1680

gaagagaaac gatctacatc attgtcatct cccagaaacc tgaactcatc tgtaagagga     1740

gacagagtat attctccata taaccataga cacagaaaga ggggaagatc aagaagttca     1800

gattcacgtt ctcagagtag aagtgggcat gatcagaaga atcatagaaa gcatcatggg     1860

aagaaaagaa tgaaaagtaa acgatccaga agcagggaaa gtagcagacc tagagggaga     1920

agagacaaaa agagatcaag aactagagat agcagttggt ccagaagaag ccaaactctg     1980

tctctaagta gtgaaagcac aagcagatca aggtctcgta gcagtgatca tggtaaaaga     2040

agatcacgga gcagaaatag agatcgttat tatttaagaa ataattatgg aagcagatac     2100

aaatgggagt atacttatta cagtagaaac aaggacaggg atgggtacga atcatcttac     2160

aggaggagga ctctgtccag agctcattat tctagacagt cttcaagtcc agaatttaga     2220

gttcagtcct tttctgaaag aacaaatgct aggaaaaaaa ataatcacag tgagaggaag     2280

tattactact atgaaaggca cagatcaagg agcctgtcta gtaacagatc aaggactgca     2340

tctaccggga ctgaccgggt gagaaatgaa aagcctggag ggaaacgaaa atacaaaaca     2400

cggcatttgg agggtactaa cgaagtggct cagccatctc gtgaatttgc ttctaaagca     2460

aaggacagtc attaccaaaa atcttcatca aaattggatg gaaactacaa aaatgagagt     2520

gatacctttt cagacagccg atcatcagac agagagacaa aacacaaaag gagaaaaagg     2580

aagacccgga gcctaagtgt agagatagtt tatgaaggaa aagctactga tacaactaaa     2640

caccataaaa agaaaaagaa gaaacataag aagaagcata agaaacacca tggagataat     2700

gcttcacgtt ccccagttgt aattaccatt gacagtgaca gtgataagga ttctgaagta     2760

aaggaggata cagaatgtga caatagtggt cctcaagacc ctctacaaaa tgagtttttg     2820

gctccttcct tggaaccatt tgaaactaaa gatgtagtta caatagaagc tgaatttggt     2880

gtgctggaca aggaatgtga tattgccaca cttagtaaca acttgaataa tgccaacaaa     2940

actgtagata atattccacc tctggcagct tcagttgaac aaactctcga tgtaagagaa     3000

gagagcacct ttgtttctga tttggagaac cagcccagta acattgtgtc tcttcaaact     3060

gagccatcaa ggcaattgcc atcgccacgg acatcattaa tgtcagtatg tcttggtaga     3120

gactgtgata tgtcttaa                                                   3138


<210>  138
<211>  1045
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gly Ser Gln Pro Pro Leu Gly Ser Pro Leu Ser Arg Glu Glu Gly 
1               5                   10                  15      


Glu Ala Pro Pro Pro Ala Pro Ala Ser Glu Gly Arg Arg Arg Ser Arg 
            20                  25                  30          


Arg Val Arg Leu Arg Gly Ser Cys Arg His Arg Pro Ser Phe Leu Gly 
        35                  40                  45              


Cys Arg Glu Leu Ala Ala Ser Ala Pro Ala Arg Pro Ala Pro Ala Ser 
    50                  55                  60                  


Ser Glu Ile Met Ala Ser Ala Ala Lys Glu Phe Lys Met Asp Asn Phe 
65                  70                  75                  80  


Ser Pro Lys Ala Gly Thr Ser Lys Leu Gln Gln Thr Val Pro Ala Asp 
                85                  90                  95      


Ala Ser Pro Asp Ser Lys Cys Pro Ile Cys Leu Asp Arg Phe Asp Asn 
            100                 105                 110         


Val Ser Tyr Leu Asp Arg Cys Leu His Lys Phe Cys Phe Arg Cys Val 
        115                 120                 125             


Gln Glu Trp Ser Lys Asn Lys Ala Glu Cys Pro Leu Cys Lys Gln Pro 
    130                 135                 140                 


Phe Asp Ser Ile Phe His Ser Val Arg Ala Glu Asp Asp Phe Lys Glu 
145                 150                 155                 160 


Tyr Val Leu Arg Pro Ser Tyr Asn Gly Ser Phe Val Thr Pro Asp Arg 
                165                 170                 175     


Arg Phe Arg Tyr Arg Thr Thr Leu Thr Arg Glu Arg Asn Ala Ser Val 
            180                 185                 190         


Tyr Ser Pro Ser Gly Pro Val Asn Arg Arg Thr Thr Thr Pro Pro Asp 
        195                 200                 205             


Ser Gly Val Leu Phe Glu Gly Leu Gly Ile Ser Thr Arg Pro Arg Asp 
    210                 215                 220                 


Val Glu Ile Pro Gln Phe Met Arg Gln Ile Ala Val Arg Arg Pro Thr 
225                 230                 235                 240 


Thr Ala Asp Glu Arg Ser Leu Arg Lys Ile Gln Glu Gln Asp Ile Ile 
                245                 250                 255     


Asn Phe Arg Arg Thr Leu Tyr Arg Ala Gly Ala Arg Val Arg Asn Ile 
            260                 265                 270         


Glu Asp Gly Gly Arg Tyr Arg Asp Ile Ser Ala Glu Phe Phe Arg Arg 
        275                 280                 285             


Asn Pro Ala Cys Leu His Arg Leu Val Pro Trp Leu Lys Arg Glu Leu 
    290                 295                 300                 


Thr Val Leu Phe Gly Ala His Gly Ser Leu Val Asn Ile Val Gln His 
305                 310                 315                 320 


Ile Ile Met Ser Asn Val Thr Arg Tyr Asp Leu Glu Ser Gln Ala Phe 
                325                 330                 335     


Val Ser Asp Leu Arg Pro Phe Leu Leu Asn Arg Thr Glu His Phe Ile 
            340                 345                 350         


His Glu Phe Ile Ser Phe Ala Arg Ser Pro Phe Asn Met Ala Ala Phe 
        355                 360                 365             


Asp Gln His Ala Asn Tyr Asp Cys Pro Ala Pro Ser Tyr Glu Glu Gly 
    370                 375                 380                 


Ser His Ser Asp Ser Ser Val Ile Thr Ile Ser Pro Asp Glu Ala Glu 
385                 390                 395                 400 


Thr Gln Glu Leu Asp Ile Asn Val Ala Thr Val Ser Gln Ala Pro Trp 
                405                 410                 415     


Asp Asp Glu Thr Pro Gly Pro Ser Tyr Ser Ser Ser Glu Gln Val His 
            420                 425                 430         


Val Thr Met Ser Ser Leu Leu Asn Thr Ser Asp Ser Ser Asp Glu Glu 
        435                 440                 445             


Leu Val Thr Gly Gly Ala Thr Ser Gln Ile Gln Gly Val Gln Thr Asn 
    450                 455                 460                 


Asp Asp Leu Asn Asn Asp Ser Asp Asp Ser Ser Asp Asn Cys Val Ile 
465                 470                 475                 480 


Val Gly Phe Val Lys Pro Leu Ala Glu Arg Thr Pro Glu Leu Val Glu 
                485                 490                 495     


Leu Ser Ser Asp Ser Glu Asp Leu Gly Ser Tyr Glu Lys Met Glu Thr 
            500                 505                 510         


Val Lys Thr Gln Glu Gln Glu Gln Ser Tyr Ser Ser Gly Asp Ser Asp 
        515                 520                 525             


Val Ser Arg Cys Ser Ser Pro His Ser Val Leu Gly Lys Asp Glu Gln 
    530                 535                 540                 


Ile Asn Lys Gly His Cys Asp Ser Ser Thr Arg Ile Lys Ser Lys Lys 
545                 550                 555                 560 


Glu Glu Lys Arg Ser Thr Ser Leu Ser Ser Pro Arg Asn Leu Asn Ser 
                565                 570                 575     


Ser Val Arg Gly Asp Arg Val Tyr Ser Pro Tyr Asn His Arg His Arg 
            580                 585                 590         


Lys Arg Gly Arg Ser Arg Ser Ser Asp Ser Arg Ser Gln Ser Arg Ser 
        595                 600                 605             


Gly His Asp Gln Lys Asn His Arg Lys His His Gly Lys Lys Arg Met 
    610                 615                 620                 


Lys Ser Lys Arg Ser Arg Ser Arg Glu Ser Ser Arg Pro Arg Gly Arg 
625                 630                 635                 640 


Arg Asp Lys Lys Arg Ser Arg Thr Arg Asp Ser Ser Trp Ser Arg Arg 
                645                 650                 655     


Ser Gln Thr Leu Ser Leu Ser Ser Glu Ser Thr Ser Arg Ser Arg Ser 
            660                 665                 670         


Arg Ser Ser Asp His Gly Lys Arg Arg Ser Arg Ser Arg Asn Arg Asp 
        675                 680                 685             


Arg Tyr Tyr Leu Arg Asn Asn Tyr Gly Ser Arg Tyr Lys Trp Glu Tyr 
    690                 695                 700                 


Thr Tyr Tyr Ser Arg Asn Lys Asp Arg Asp Gly Tyr Glu Ser Ser Tyr 
705                 710                 715                 720 


Arg Arg Arg Thr Leu Ser Arg Ala His Tyr Ser Arg Gln Ser Ser Ser 
                725                 730                 735     


Pro Glu Phe Arg Val Gln Ser Phe Ser Glu Arg Thr Asn Ala Arg Lys 
            740                 745                 750         


Lys Asn Asn His Ser Glu Arg Lys Tyr Tyr Tyr Tyr Glu Arg His Arg 
        755                 760                 765             


Ser Arg Ser Leu Ser Ser Asn Arg Ser Arg Thr Ala Ser Thr Gly Thr 
    770                 775                 780                 


Asp Arg Val Arg Asn Glu Lys Pro Gly Gly Lys Arg Lys Tyr Lys Thr 
785                 790                 795                 800 


Arg His Leu Glu Gly Thr Asn Glu Val Ala Gln Pro Ser Arg Glu Phe 
                805                 810                 815     


Ala Ser Lys Ala Lys Asp Ser His Tyr Gln Lys Ser Ser Ser Lys Leu 
            820                 825                 830         


Asp Gly Asn Tyr Lys Asn Glu Ser Asp Thr Phe Ser Asp Ser Arg Ser 
        835                 840                 845             


Ser Asp Arg Glu Thr Lys His Lys Arg Arg Lys Arg Lys Thr Arg Ser 
    850                 855                 860                 


Leu Ser Val Glu Ile Val Tyr Glu Gly Lys Ala Thr Asp Thr Thr Lys 
865                 870                 875                 880 


His His Lys Lys Lys Lys Lys Lys His Lys Lys Lys His Lys Lys His 
                885                 890                 895     


His Gly Asp Asn Ala Ser Arg Ser Pro Val Val Ile Thr Ile Asp Ser 
            900                 905                 910         


Asp Ser Asp Lys Asp Ser Glu Val Lys Glu Asp Thr Glu Cys Asp Asn 
        915                 920                 925             


Ser Gly Pro Gln Asp Pro Leu Gln Asn Glu Phe Leu Ala Pro Ser Leu 
    930                 935                 940                 


Glu Pro Phe Glu Thr Lys Asp Val Val Thr Ile Glu Ala Glu Phe Gly 
945                 950                 955                 960 


Val Leu Asp Lys Glu Cys Asp Ile Ala Thr Leu Ser Asn Asn Leu Asn 
                965                 970                 975     


Asn Ala Asn Lys Thr Val Asp Asn Ile Pro Pro Leu Ala Ala Ser Val 
            980                 985                 990         


Glu Gln Thr Leu Asp Val Arg Glu  Glu Ser Thr Phe Val  Ser Asp Leu 
        995                 1000                 1005             


Glu Asn  Gln Pro Ser Asn Ile  Val Ser Leu Gln Thr  Glu Pro Ser 
    1010                 1015                 1020             


Arg Gln  Leu Pro Ser Pro Arg  Thr Ser Leu Met Ser  Val Cys Leu 
    1025                 1030                 1035             


Gly Arg  Asp Cys Asp Met Ser  
    1040                 1045 


<210>  139
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  139
atgacatcct cctgctgtgt caccaacaac ttgcaagcct ctctcaagag ctgcccccgg       60

cctgcctcgg tctgttccag cggcgtgaac tgccggcctg agctgtgcct gggctatgtc      120

tgccagccca tggcatgcct gccttcggtc tgcctgccca ccaccttccg gccagccagc      180

tgcctctcca aaacctatct atccagttcc tgccaggcag ccagtggcat ctccggctcc      240

atgggccccg gcagctggta cagcgaaggg gccttcaatg gcaatgagaa ggaaaccatg      300

cagttcctta acgaccgcct ggccagctac ctgacgaggg tgcggcagct ggagcaggag      360

aatgcggagc tggagagcag gatccaagag gcctctcact cccaggtgct caccatgact      420

cctgactacc agtctcattt caggaccatt gaggagctcc agcagaagat tctgtgtacc      480

aaggcagaga atgccaggat ggttgtgaac attgataatg ccaaactggc tgccgatgac      540

ttcagggcca agtacgaggc agagctggcc atgcggcagc tggtggaggc cgacatcaat      600

ggcctgcgca ggatcctgga tgatctcact ctgtgcaagg ctgacctgga ggcccaggtt      660

gagtccctga aggaggagct gatgtgcctc aaaaagaacc atgaggagga agtcggttcc      720

cttcgatgcc agcttgggga ccgccttaac atcgaggtgg acgctgcacc cccggtggac      780

ctgaccaggg tgctggagga gatgcggtgt cagtacgagg ccatggtgga ggccaaccgc      840

agggacgtgg aggaatggtt caatatgcag atggaggagc ttaaccaaca ggtggccaca      900

agctctgagc agcttcagaa ctaccagtca gacatcattg acctgagacg cacggtcaac      960

acgctggaga tcgagctgca ggcccagcac agcctgaggg actccctgga aaacacgctg     1020

acggagagtg aggcccgcta cagctcccag ctggcccaga tgcagtgcat gatcaccaac     1080

gttgaggccc agctggctga gatccgggct gacctggagc ggcagaacca ggagtaccag     1140

gtgctgctgg acgtccgggc ccggctggag ggcgagatca acacgtaccg gagcctgctg     1200

gagaacgagg actgcaagct gccctgtaac ccatgctcca ctccttcctg caccacctgt     1260

gtgccctccc catgcgtgcc ccgcaccgtc tgtgtgccac gcactgttgg catgccttgc     1320

tcaccctgcc cccagggccg ctactga                                         1347


<210>  140
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Thr Ser Ser Cys Cys Val Thr Asn Asn Leu Gln Ala Ser Leu Lys 
1               5                   10                  15      


Ser Cys Pro Arg Pro Ala Ser Val Cys Ser Ser Gly Val Asn Cys Arg 
            20                  25                  30          


Pro Glu Leu Cys Leu Gly Tyr Val Cys Gln Pro Met Ala Cys Leu Pro 
        35                  40                  45              


Ser Val Cys Leu Pro Thr Thr Phe Arg Pro Ala Ser Cys Leu Ser Lys 
    50                  55                  60                  


Thr Tyr Leu Ser Ser Ser Cys Gln Ala Ala Ser Gly Ile Ser Gly Ser 
65                  70                  75                  80  


Met Gly Pro Gly Ser Trp Tyr Ser Glu Gly Ala Phe Asn Gly Asn Glu 
                85                  90                  95      


Lys Glu Thr Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr Leu Thr 
            100                 105                 110         


Arg Val Arg Gln Leu Glu Gln Glu Asn Ala Glu Leu Glu Ser Arg Ile 
        115                 120                 125             


Gln Glu Ala Ser His Ser Gln Val Leu Thr Met Thr Pro Asp Tyr Gln 
    130                 135                 140                 


Ser His Phe Arg Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr 
145                 150                 155                 160 


Lys Ala Glu Asn Ala Arg Met Val Val Asn Ile Asp Asn Ala Lys Leu 
                165                 170                 175     


Ala Ala Asp Asp Phe Arg Ala Lys Tyr Glu Ala Glu Leu Ala Met Arg 
            180                 185                 190         


Gln Leu Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Ile Leu Asp Asp 
        195                 200                 205             


Leu Thr Leu Cys Lys Ala Asp Leu Glu Ala Gln Val Glu Ser Leu Lys 
    210                 215                 220                 


Glu Glu Leu Met Cys Leu Lys Lys Asn His Glu Glu Glu Val Gly Ser 
225                 230                 235                 240 


Leu Arg Cys Gln Leu Gly Asp Arg Leu Asn Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Pro Pro Val Asp Leu Thr Arg Val Leu Glu Glu Met Arg Cys Gln Tyr 
            260                 265                 270         


Glu Ala Met Val Glu Ala Asn Arg Arg Asp Val Glu Glu Trp Phe Asn 
        275                 280                 285             


Met Gln Met Glu Glu Leu Asn Gln Gln Val Ala Thr Ser Ser Glu Gln 
    290                 295                 300                 


Leu Gln Asn Tyr Gln Ser Asp Ile Ile Asp Leu Arg Arg Thr Val Asn 
305                 310                 315                 320 


Thr Leu Glu Ile Glu Leu Gln Ala Gln His Ser Leu Arg Asp Ser Leu 
                325                 330                 335     


Glu Asn Thr Leu Thr Glu Ser Glu Ala Arg Tyr Ser Ser Gln Leu Ala 
            340                 345                 350         


Gln Met Gln Cys Met Ile Thr Asn Val Glu Ala Gln Leu Ala Glu Ile 
        355                 360                 365             


Arg Ala Asp Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp 
    370                 375                 380                 


Val Arg Ala Arg Leu Glu Gly Glu Ile Asn Thr Tyr Arg Ser Leu Leu 
385                 390                 395                 400 


Glu Asn Glu Asp Cys Lys Leu Pro Cys Asn Pro Cys Ser Thr Pro Ser 
                405                 410                 415     


Cys Thr Thr Cys Val Pro Ser Pro Cys Val Pro Arg Thr Val Cys Val 
            420                 425                 430         


Pro Arg Thr Val Gly Met Pro Cys Ser Pro Cys Pro Gln Gly Arg Tyr 
        435                 440                 445             


<210>  141
<211>  2460
<212>  DNA
<213>  Homo sapiens

<400>  141
atgcctctga ccagtgcctt cagggctgtg gacaacgacc ctgggatcat tgtctggaga       60

atagagaaaa tggagctggc gctggtgcct gtgagcgccc acggcaactt ctatgagggg      120

gactgctacg tcatcctctc gacccggaga gtggccagtc tcctatccca ggacatccac      180

ttctggatcg ggaaggactc ctcccaggat gagcaaagct gcgcagccat atataccaca      240

cagctggacg actacctggg aggcagccct gtgcagcacc gagaggtcca gtaccatgag      300

tcagacactt tccgtggcta cttcaagcag ggcatcatct acaagcaggg gggtgtcgcc      360

tctgggatga agcacgtgga gaccaatacc tacgacgtga agcggctgct acatgtgaaa      420

gggaaaagaa acatcagggc taccgaggtg gaaatgagct gggacagttt caaccgaggt      480

gatgtcttct tgctggacct tgggaaagtc atcatccaat ggaatggccc agagagcaac      540

agtggggagc gcctgaaggc tatgcttctg gcaaaggata ttcgagacag ggagcgaggg      600

ggccgtgcta aaataggagt gatcgaggga gacaaggagg cagccagccc agagctgatg      660

aaggtccttc aggacaccct tggccgacgc tccattatca agcctacagt ccctgatgag      720

atcatagatc agaagcagaa atcaactatc atgttgtatc atatctcaga ttcagctggg      780

cagctggcag tcacagaggt agcaacaagg cctctggtcc aggacttact gaaccatgat      840

gactgctaca tcctggacca aagtggaacc aaaatctacg tgtggaaagg aaaaggagcc      900

acaaaggctg aaaaacaggc agccatgtct aaagcgctgg gcttcatcaa gatgaagagc      960

taccccagca gcaccaatgt ggagaccgtc aacgatggtg ctgagtcggc catgttcaag     1020

cagctgttcc agaagtggtc agtaaaggac cagaccatgg gcctggggaa aacgttcagc     1080

attggtaaaa ttgctaaagt tttccaggat aaatttgatg tgactctgct acacaccaag     1140

ccagaggtag ctgcccagga aagaatggtc gatgatggca acggaaaagt tgaggtctgg     1200

agaattgaga acctggagct ggtccctgtg gagtatcaat ggtatggctt cttttatggg     1260

ggagactgtt atctggtcct ctacacatac gaggtaaatg ggaagccaca tcacatcttg     1320

tacatctggc agggccgcca cgcctcacag gatgagctgg cagcctcagc ataccaggca     1380

gtggaggtgg atcggcagtt tgatggggct gctgtgcagg ttcgagtcag gatgggaacg     1440

gagccacgcc acttcatggc catcttcaaa gggaagctag ttatctttga gggtgggact     1500

tccaggaagg gaaatgccga gcctgaccct ccagtaagac tcttccaaat tcatggaaat     1560

gacaaatcta acaccaaagc agtggaagtt ccagcctttg cctcctccct aaactccaat     1620

gatgtctttc tgctgcgaac tcaggcagag cactacctgt ggtatggcaa ggggtctagt     1680

ggggatgagc gggcaatggc taaggagctg gccagccttc tctgtgatgg cagcgagaac     1740

actgtggccg agggccagga gccagccgag ttctgggacc tactgggagg gaaaactccc     1800

tatgccaatg ataaaagact tcagcaggaa atcctagatg tccagtctcg tctctttgaa     1860

tgttccaata agaccggcca attcgttgtc actgagatca cagacttcac ccaggatgac     1920

ctgaacccta ctgacgtgat gctcctagat acctgggacc aggtgttctt gtggattggg     1980

gctgaggcca atgccacgga gaaggagagt gcccttgcca cagcacagca gtacctgcac     2040

actcacccca gcggccgaga tcccgacaca ccaatcctga tcattaagca ggggtttgag     2100

cctcccatct tcacaggctg gttcctagcc tgggacccta acatttggag tgcaggaaaa     2160

acatatgaac aattaaaaga agagctggga gatgctgctg ctatcatgcg aatcactgct     2220

gacatgaaga atgcaaccct ctccctgaat tctaatgaca gtgagccaaa atattaccct     2280

atagcagttc tgttgaaaaa ccagaatcag gagctgcctg aggatgtaaa ccctgccaaa     2340

aaggagaatt acctctctga acaggacttt gtgtctgtgt ttggcatcac aagagggcaa     2400

tttgcagctc tgcctggctg gaaacagctc caaatgaaga aagaaaaggg gcttttctaa     2460


<210>  142
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Pro Leu Thr Ser Ala Phe Arg Ala Val Asp Asn Asp Pro Gly Ile 
1               5                   10                  15      


Ile Val Trp Arg Ile Glu Lys Met Glu Leu Ala Leu Val Pro Val Ser 
            20                  25                  30          


Ala His Gly Asn Phe Tyr Glu Gly Asp Cys Tyr Val Ile Leu Ser Thr 
        35                  40                  45              


Arg Arg Val Ala Ser Leu Leu Ser Gln Asp Ile His Phe Trp Ile Gly 
    50                  55                  60                  


Lys Asp Ser Ser Gln Asp Glu Gln Ser Cys Ala Ala Ile Tyr Thr Thr 
65                  70                  75                  80  


Gln Leu Asp Asp Tyr Leu Gly Gly Ser Pro Val Gln His Arg Glu Val 
                85                  90                  95      


Gln Tyr His Glu Ser Asp Thr Phe Arg Gly Tyr Phe Lys Gln Gly Ile 
            100                 105                 110         


Ile Tyr Lys Gln Gly Gly Val Ala Ser Gly Met Lys His Val Glu Thr 
        115                 120                 125             


Asn Thr Tyr Asp Val Lys Arg Leu Leu His Val Lys Gly Lys Arg Asn 
    130                 135                 140                 


Ile Arg Ala Thr Glu Val Glu Met Ser Trp Asp Ser Phe Asn Arg Gly 
145                 150                 155                 160 


Asp Val Phe Leu Leu Asp Leu Gly Lys Val Ile Ile Gln Trp Asn Gly 
                165                 170                 175     


Pro Glu Ser Asn Ser Gly Glu Arg Leu Lys Ala Met Leu Leu Ala Lys 
            180                 185                 190         


Asp Ile Arg Asp Arg Glu Arg Gly Gly Arg Ala Lys Ile Gly Val Ile 
        195                 200                 205             


Glu Gly Asp Lys Glu Ala Ala Ser Pro Glu Leu Met Lys Val Leu Gln 
    210                 215                 220                 


Asp Thr Leu Gly Arg Arg Ser Ile Ile Lys Pro Thr Val Pro Asp Glu 
225                 230                 235                 240 


Ile Ile Asp Gln Lys Gln Lys Ser Thr Ile Met Leu Tyr His Ile Ser 
                245                 250                 255     


Asp Ser Ala Gly Gln Leu Ala Val Thr Glu Val Ala Thr Arg Pro Leu 
            260                 265                 270         


Val Gln Asp Leu Leu Asn His Asp Asp Cys Tyr Ile Leu Asp Gln Ser 
        275                 280                 285             


Gly Thr Lys Ile Tyr Val Trp Lys Gly Lys Gly Ala Thr Lys Ala Glu 
    290                 295                 300                 


Lys Gln Ala Ala Met Ser Lys Ala Leu Gly Phe Ile Lys Met Lys Ser 
305                 310                 315                 320 


Tyr Pro Ser Ser Thr Asn Val Glu Thr Val Asn Asp Gly Ala Glu Ser 
                325                 330                 335     


Ala Met Phe Lys Gln Leu Phe Gln Lys Trp Ser Val Lys Asp Gln Thr 
            340                 345                 350         


Met Gly Leu Gly Lys Thr Phe Ser Ile Gly Lys Ile Ala Lys Val Phe 
        355                 360                 365             


Gln Asp Lys Phe Asp Val Thr Leu Leu His Thr Lys Pro Glu Val Ala 
    370                 375                 380                 


Ala Gln Glu Arg Met Val Asp Asp Gly Asn Gly Lys Val Glu Val Trp 
385                 390                 395                 400 


Arg Ile Glu Asn Leu Glu Leu Val Pro Val Glu Tyr Gln Trp Tyr Gly 
                405                 410                 415     


Phe Phe Tyr Gly Gly Asp Cys Tyr Leu Val Leu Tyr Thr Tyr Glu Val 
            420                 425                 430         


Asn Gly Lys Pro His His Ile Leu Tyr Ile Trp Gln Gly Arg His Ala 
        435                 440                 445             


Ser Gln Asp Glu Leu Ala Ala Ser Ala Tyr Gln Ala Val Glu Val Asp 
    450                 455                 460                 


Arg Gln Phe Asp Gly Ala Ala Val Gln Val Arg Val Arg Met Gly Thr 
465                 470                 475                 480 


Glu Pro Arg His Phe Met Ala Ile Phe Lys Gly Lys Leu Val Ile Phe 
                485                 490                 495     


Glu Gly Gly Thr Ser Arg Lys Gly Asn Ala Glu Pro Asp Pro Pro Val 
            500                 505                 510         


Arg Leu Phe Gln Ile His Gly Asn Asp Lys Ser Asn Thr Lys Ala Val 
        515                 520                 525             


Glu Val Pro Ala Phe Ala Ser Ser Leu Asn Ser Asn Asp Val Phe Leu 
    530                 535                 540                 


Leu Arg Thr Gln Ala Glu His Tyr Leu Trp Tyr Gly Lys Gly Ser Ser 
545                 550                 555                 560 


Gly Asp Glu Arg Ala Met Ala Lys Glu Leu Ala Ser Leu Leu Cys Asp 
                565                 570                 575     


Gly Ser Glu Asn Thr Val Ala Glu Gly Gln Glu Pro Ala Glu Phe Trp 
            580                 585                 590         


Asp Leu Leu Gly Gly Lys Thr Pro Tyr Ala Asn Asp Lys Arg Leu Gln 
        595                 600                 605             


Gln Glu Ile Leu Asp Val Gln Ser Arg Leu Phe Glu Cys Ser Asn Lys 
    610                 615                 620                 


Thr Gly Gln Phe Val Val Thr Glu Ile Thr Asp Phe Thr Gln Asp Asp 
625                 630                 635                 640 


Leu Asn Pro Thr Asp Val Met Leu Leu Asp Thr Trp Asp Gln Val Phe 
                645                 650                 655     


Leu Trp Ile Gly Ala Glu Ala Asn Ala Thr Glu Lys Glu Ser Ala Leu 
            660                 665                 670         


Ala Thr Ala Gln Gln Tyr Leu His Thr His Pro Ser Gly Arg Asp Pro 
        675                 680                 685             


Asp Thr Pro Ile Leu Ile Ile Lys Gln Gly Phe Glu Pro Pro Ile Phe 
    690                 695                 700                 


Thr Gly Trp Phe Leu Ala Trp Asp Pro Asn Ile Trp Ser Ala Gly Lys 
705                 710                 715                 720 


Thr Tyr Glu Gln Leu Lys Glu Glu Leu Gly Asp Ala Ala Ala Ile Met 
                725                 730                 735     


Arg Ile Thr Ala Asp Met Lys Asn Ala Thr Leu Ser Leu Asn Ser Asn 
            740                 745                 750         


Asp Ser Glu Pro Lys Tyr Tyr Pro Ile Ala Val Leu Leu Lys Asn Gln 
        755                 760                 765             


Asn Gln Glu Leu Pro Glu Asp Val Asn Pro Ala Lys Lys Glu Asn Tyr 
    770                 775                 780                 


Leu Ser Glu Gln Asp Phe Val Ser Val Phe Gly Ile Thr Arg Gly Gln 
785                 790                 795                 800 


Phe Ala Ala Leu Pro Gly Trp Lys Gln Leu Gln Met Lys Lys Glu Lys 
                805                 810                 815     


Gly Leu Phe 
            


<210>  143
<211>  3546
<212>  DNA
<213>  Homo sapiens

<400>  143
atggggccag aacggacagg ggccgcgccg ctgccgctgc tgctggtgtt agcgctcagt       60

caaggcattt taaattgttg tttggcctac aatgttggtc tcccagaagc aaaaatattt      120

tccggtcctt caagtgaaca gtttggctat gcagtgcagc agtttataaa tccaaaaggc      180

aactggttac tggttggttc accctggagt ggctttcctg agaaccgaat gggagatgtg      240

tataaatgtc ctgttgacct atccactgcc acatgtgaaa aactaaattt gcaaacttca      300

acaagcattc caaatgttac tgagatgaaa accaacatga gcctcggctt gatcctcacc      360

aggaacatgg gaactggagg ttttctcaca tgtggtcctc tgtgggcaca gcaatgtggg      420

aatcagtatt acacaacggg tgtgtgttct gacatcagtc ctgattttca gctctcagcc      480

agcttctcac ctgcaactca gccctgccct tccctcatag atgttgtggt tgtgtgtgat      540

gaatcaaata gtatttatcc ttgggatgca gtaaagaatt ttttggaaaa atttgtacaa      600

ggcctggata taggccccac aaagacacag gtggggttaa ttcagtatgc caataatcca      660

agagttgtgt ttaacttgaa cacatataaa accaaagaag aaatgattgt agcaacatcc      720

cagacatccc aatatggtgg ggacctcaca aacacattcg gagcaattca atatgcaaga      780

aaatatgctt attcagcagc ttctggtggg cgacgaagtg ctacgaaagt aatggtagtt      840

gtaactgacg gtgaatcaca tgatggttca atgttgaaag ctgtgattga tcaatgcaac      900

catgacaata tactgaggtt tggcatagca gttcttgggt acttaaacag aaacgccctt      960

gatactaaaa atttaataaa agaaataaaa gcaatcgcta gtattccaac agaaagatac     1020

tttttcaatg tgtctgatga agcagctcta ctagaaaagg ctgggacatt aggagaacaa     1080

attttcagca ttgaaggtac tgttcaagga ggagacaact ttcagatgga aatgtcacaa     1140

gtgggattca gtgcagatta ctcttctcaa aatgatattc tgatgctggg tgcagtggga     1200

gcttttggct ggagtgggac cattgtccag aagacatctc atggccattt gatctttcct     1260

aaacaagcct ttgaccaaat tctgcaggac agaaatcaca gttcatattt aggttactct     1320

gtggctgcaa tttctactgg agaaagcact cactttgttg ctggtgctcc tcgggcaaat     1380

tataccggcc agatagtgct atatagtgtg aatgagaatg gcaatatcac ggttattcag     1440

gctcaccgag gtgaccagat tggctcctat tttggtagtg tgctgtgttc agttgatgtg     1500

gataaagaca ccattacaga cgtgctcttg gtaggtgcac caatgtacat gagtgaccta     1560

aagaaagagg aaggaagagt ctacctgttt actatcaaag agggcatttt gggtcagcac     1620

caatttcttg aaggccccga gggcattgaa aacactcgat ttggttcagc aattgcagct     1680

ctttcagaca tcaacatgga tggctttaat gatgtgattg ttggttcacc actagaaaat     1740

cagaattctg gagctgtata catttacaat ggtcatcagg gcactatccg cacaaagtat     1800

tcccagaaaa tcttgggatc cgatggagcc tttaggagcc atctccagta ctttgggagg     1860

tccttggatg gctatggaga tttaaatggg gattccatca ccgatgtgtc tattggtgcc     1920

tttggacaag tggttcaact ctggtcacaa agtattgctg atgtagctat agaagcttca     1980

ttcacaccag aaaaaatcac tttggtcaac aagaatgctc agataattct caaactctgc     2040

ttcagtgcaa agttcagacc tactaagcaa aacaatcaag tggccattgt atataacatc     2100

acacttgatg cagatggatt ttcatccaga gtaacctcca gggggttatt taaagaaaac     2160

aatgaaaggt gcctgcagaa gaatatggta gtaaatcaag cacagagttg ccccgagcac     2220

atcatttata tacaggagcc ctctgatgtt gtcaactctt tggatttgcg tgtggacatc     2280

agtctggaaa accctggcac tagccctgcc cttgaagcct attctgagac tgccaaggtc     2340

ttcagtattc ctttccacaa agactgtggt gaggacggac tttgcatttc tgatctagtc     2400

ctagatgtcc gacaaatacc agctgctcaa gaacaaccct ttattgtcag caaccaaaac     2460

aaaaggttaa cattttcagt aacgctgaaa aataaaaggg aaagtgcata caacactgga     2520

attgttgttg atttttcaga aaacttgttt tttgcatcat tctccctgcc ggttgatggg     2580

acagaagtaa catgccaggt ggctgcatct cagaagtctg ttgcctgcga tgtaggctac     2640

cctgctttaa agagagaaca acaggtgact tttactatta actttgactt caatcttcaa     2700

aaccttcaga atcaggcgtc tctcagtttc caagccttaa gtgaaagcca agaagaaaac     2760

aaggctgata atttggtcaa cctcaaaatt cctctcctgt atgatgctga aattcactta     2820

acaagatcta ccaacataaa tttttatgaa atctcttcgg atgggaatgt tccttcaatc     2880

gtgcacagtt ttgaagatgt tggtccaaaa ttcatcttct ccctgaaggt aacaacagga     2940

agtgttccag taagcatggc aactgtaatc atccacatcc ctcagtatac caaagaaaag     3000

aacccactga tgtacctaac tggggtgcaa acagacaagg ctggtgacat cagttgtaat     3060

gcagatatca atccactgaa aataggacaa acatcttctt ctgtatcttt caaaagtgaa     3120

aatttcaggc acaccaaaga attgaactgc agaactgctt cctgtagtaa tgttacctgc     3180

tggttgaaag acgttcacat gaaaggagaa tactttgtta atgtgactac cagaatttgg     3240

aacgggactt tcgcatcatc aacgttccag acagtacagc taacggcagc tgcagaaatc     3300

aacacctata accctgagat atatgtgatt gaagataaca ctgttacgat tcccctgatg     3360

ataatgaaac ctgatgagaa agccgaagta ccaacaggag ttataatagg aagtataatt     3420

gctggaatcc ttttgctgtt agctctggtt gcaattttat ggaagctcgg cttcttcaaa     3480

agaaaatatg aaaagatgac caaaaatcca gatgagattg atgagaccac agagctcagt     3540

agctga                                                                3546


<210>  144
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  145
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  145
atgctggcgc tactgtgttc ctgcctgctc ctggcagccg gtgcctcgga cgcctggacg       60

ggcgaggact cggcggagcc caactctgac tcggcggagt ggatccgaga catgtacgcc      120

aaggtcacgg agatctggca ggaggtcatg cagcggcggg acgacgacgg cgcgctccac      180

gccgcctgcc aggtgcagcc gtcggccacg ctggacgccg cgcagccccg ggtgaccggc      240

gtcgtcctct tccggcagct tgcgccccgc gccaagctcg acgccttctt cgccctggag      300

ggcttcccga ccgagccgaa cagctccagc cgcgccatcc acgtgcacca gttcggggac      360

ctgagccagg gctgcgagtc caccgggccc cactacaacc cgctggccgt gccgcacccg      420

cagcacccgg gcgacttcgg caacttcgcg gtccgcgacg gcagcctctg gaggtaccgc      480

gccggcctgg ccgcctcgct cgcgggcccg cactccatcg tgggccgggc cgtggtcgtc      540

cacgctggcg aggacgacct gggccgcggc ggcaaccagg ccagcgtgga gaacgggaac      600

gcgggccggc ggctggcctg ctgcgtggtg ggcgtgtgcg ggcccgggct ctgggagcgc      660

caggcgcggg agcactcaga gcgcaagaag cggcggcgcg agagcgagtg caaggccgcc      720

tga                                                                    723


<210>  146
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 
1               5                   10                  15      


Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala 
            20                  25                  30          


Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu 
        35                  40                  45              


Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln 
    50                  55                  60                  


Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly 
65                  70                  75                  80  


Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe 
                85                  90                  95      


Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala 
            100                 105                 110         


Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr 
        115                 120                 125             


Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly 
    130                 135                 140                 


Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg 
145                 150                 155                 160 


Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg 
                165                 170                 175     


Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn 
            180                 185                 190         


Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys 
        195                 200                 205             


Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu 
    210                 215                 220                 


His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala 
225                 230                 235                 240 


<210>  147
<211>  3435
<212>  DNA
<213>  Homo sapiens

<400>  147
atgaagttaa gccgccagtt caccgtgttc ggcagtgcga tcttctgtgt ggtgattttc       60

tcgctctacc tgatgctgga ccggggtcac ttagactacc ccaggaaccc gcgccgcgag      120

ggctccttcc ctcagggcca gctctcaatg ttgcaagaaa aaatagacca tttggagcgt      180

ttgctagctg agaataatga gatcatctca aatattagag actcagtcat caatttgagt      240

gagtctgtgg aggatggtcc gaaaagttca caaagcaatt tcagccaagg tgctggctca      300

catcttctgc cctcacaatt atccctctca gttgacactg cagactgtct gtttgcttca      360

caaagtggaa gtcacaattc agatgtgcag atgttggatg tttacagtct aatttctttt      420

gacaatccag atggtggagt ttggaagcaa ggatttgaca ttacttatga atctaatgaa      480

tgggacactg aaccccttca agtctttgtg gtgcctcatt cccataacga cccaggttgg      540

ttgaagactt tcaatgacta ctttagagac aagactcagt atatttttaa taacatggtc      600

ctaaagctga aagaagactc acggaggaag tttatttggt ctgagatctc ttacctttca      660

aagtggtggg atattataga tattcagaag aaggatgctg ttaaaagttt aatagaaaat      720

ggtcagcttg aaattgtgac aggtggctgg gttatgcctg atgaagctac tccacattat      780

tttgccttaa ttgatcaact aattgaagga catcagtggc tggaaaataa tataggagtg      840

aaacctcggt ccggctgggc tattgatccc tttggacact caccaacaat ggcttatctt      900

ctaaaccgtg ctggactttc tcacatgctt atccagagag ttcattatgc agttaaaaaa      960

cactttgcac tgcataaaac attggagttt ttttggagac agaattggga tctgggatct     1020

gtcacagata ttttatgcca catgatgccc ttctacagct atgacatccc tcacacttgt     1080

ggacctgatc ctaaaatatg ctgccagttt gattttaaac gtcttcctgg aggcagattt     1140

ggttgtccct ggggagtccc cccagaaaca atacatcctg gaaatgtcca aagcagggct     1200

cggatgctac tagatcagta ccgaaagaag tcaaagcttt ttcgtaccaa agttctcctg     1260

gctccactag gagatgattt ccgctactgt gaatacacgg aatgggattt acagtttaag     1320

aattatcagc agctttttga ttatatgaat tctcagtcca agtttaaagt taagatacag     1380

tttggaactt tatcagattt ttttgatgcg ctggataaag cagatgaaac tcagagagac     1440

aagggccaat cgatgttccc tgttttaagt ggagattttt tcacttatgc cgatcgagat     1500

gatcattact ggagtggcta ttttacatcc agaccctttt acaaacgaat ggacagaatc     1560

atggaatctc atttaagggc tgctgaaatt ctttactatt tcgccctgag acaagctcac     1620

aaatacaaga taaataaatt tctctcatca tcactttaca cggcactgac agaagccaga     1680

aggaatttgg gactgtttca acatcatgat gctatcacag gaactgcaaa agactgggtg     1740

gttgtggatt atggtaccag actttttcat tcgttaatgg ttttggagaa gataattgga     1800

aattctgcat ttcttcttat tttgaaggac aaactcacat acgactctta ctctcctgat     1860

accttcctgg agatggattt gaaacaaaaa tcacaagatt ctctgccaca aaaaaatata     1920

ataaggctga gtgcggagcc aaggtacctt gtggtctata atcctttaga acaagaccga     1980

atctcgttgg tctcagtcta tgtgagttcc ccgacagtgc aagtgttctc tgcttcagga     2040

aaacctgtgg aagttcaagt cagcgcagtt tgggatacag caaatactat ttcagaaaca     2100

gcctatgaga tctcttttcg agcacatata ccgccattgg gactgaaagt gtataagatt     2160

ttggaatcag caagttcaaa ttcacattta gctgattatg tcttgtataa gaataaagta     2220

gaagatagcg gaattttcac cataaagaat atgataaata ctgaagaagg tataacacta     2280

gagaactcct ttgttttact tcggtttgat caaactggac ttatgaagca aatgatgact     2340

aaagaagatg gtaaacacca tgaagtaaat gtgcaatttt catggtatgg aaccacaatt     2400

aaaagagaca aaagtggtgc ctacctcttc ttacctgatg gtaatgccaa gccttatgtt     2460

tacacaacac cgccctttgt cagagtgaca catggaagga tttattcgga agtgacttgc     2520

ttttttgacc atgttactca tagagtccga ctataccaca tacagggaat agaaggacag     2580

tctgtggaag tttccaatat tgtggacatc cgaaaagtat ataaccgtga gattgcaatg     2640

aaaatttctt ctgatataaa aagccaaaat agattttata ctgacctaaa tgggtaccag     2700

attcaaccta gaatgacact gagcaaattg cctcttcaag caaatgtcta tcccatgacc     2760

acaatggcct atatccagga tgccaaacat cgtttgacac tgctctctgc tcagtcatta     2820

ggggtttcga gtttgaatag tggtcagatt gaagttatca tggatcgaag actcatgcaa     2880

gatgataatc gtggccttga gcaaggtatc caggataaca agattacagc taatctattt     2940

cgaatactac tagaaaaaag aagtgctgtt aatacggaag aagaaaagaa gtcggtcagt     3000

tatccttctc tccttagcca cataacttct tctctcatga atcatccagt cattccaatg     3060

gcaaataagt tctcctcacc tacccttgag ctgcaaggtg aattctctcc attacagtca     3120

tctttgcctt gtgacattca tctggttaat ttgagaacaa tacagtcaaa ggtgggcaat     3180

gggcactcca atgaggcagc cttgatcctc cacagaaaag ggtttgattg tcggttctct     3240

agcaaaggca cagggctgtt ttgttctact actcagggaa agatattggt acagaaactt     3300

ttaaacaagt ttattgtcga aagtctcaca ccttcatcac tatccttgat gcattcacct     3360

cccggcactc agaatataag tgagatcaac ttgagtccaa tggaaatcag cacattccga     3420

atccagttga ggtga                                                      3435


<210>  148
<211>  1144
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Lys Leu Ser Arg Gln Phe Thr Val Phe Gly Ser Ala Ile Phe Cys 
1               5                   10                  15      


Val Val Ile Phe Ser Leu Tyr Leu Met Leu Asp Arg Gly His Leu Asp 
            20                  25                  30          


Tyr Pro Arg Asn Pro Arg Arg Glu Gly Ser Phe Pro Gln Gly Gln Leu 
        35                  40                  45              


Ser Met Leu Gln Glu Lys Ile Asp His Leu Glu Arg Leu Leu Ala Glu 
    50                  55                  60                  


Asn Asn Glu Ile Ile Ser Asn Ile Arg Asp Ser Val Ile Asn Leu Ser 
65                  70                  75                  80  


Glu Ser Val Glu Asp Gly Pro Lys Ser Ser Gln Ser Asn Phe Ser Gln 
                85                  90                  95      


Gly Ala Gly Ser His Leu Leu Pro Ser Gln Leu Ser Leu Ser Val Asp 
            100                 105                 110         


Thr Ala Asp Cys Leu Phe Ala Ser Gln Ser Gly Ser His Asn Ser Asp 
        115                 120                 125             


Val Gln Met Leu Asp Val Tyr Ser Leu Ile Ser Phe Asp Asn Pro Asp 
    130                 135                 140                 


Gly Gly Val Trp Lys Gln Gly Phe Asp Ile Thr Tyr Glu Ser Asn Glu 
145                 150                 155                 160 


Trp Asp Thr Glu Pro Leu Gln Val Phe Val Val Pro His Ser His Asn 
                165                 170                 175     


Asp Pro Gly Trp Leu Lys Thr Phe Asn Asp Tyr Phe Arg Asp Lys Thr 
            180                 185                 190         


Gln Tyr Ile Phe Asn Asn Met Val Leu Lys Leu Lys Glu Asp Ser Arg 
        195                 200                 205             


Arg Lys Phe Ile Trp Ser Glu Ile Ser Tyr Leu Ser Lys Trp Trp Asp 
    210                 215                 220                 


Ile Ile Asp Ile Gln Lys Lys Asp Ala Val Lys Ser Leu Ile Glu Asn 
225                 230                 235                 240 


Gly Gln Leu Glu Ile Val Thr Gly Gly Trp Val Met Pro Asp Glu Ala 
                245                 250                 255     


Thr Pro His Tyr Phe Ala Leu Ile Asp Gln Leu Ile Glu Gly His Gln 
            260                 265                 270         


Trp Leu Glu Asn Asn Ile Gly Val Lys Pro Arg Ser Gly Trp Ala Ile 
        275                 280                 285             


Asp Pro Phe Gly His Ser Pro Thr Met Ala Tyr Leu Leu Asn Arg Ala 
    290                 295                 300                 


Gly Leu Ser His Met Leu Ile Gln Arg Val His Tyr Ala Val Lys Lys 
305                 310                 315                 320 


His Phe Ala Leu His Lys Thr Leu Glu Phe Phe Trp Arg Gln Asn Trp 
                325                 330                 335     


Asp Leu Gly Ser Val Thr Asp Ile Leu Cys His Met Met Pro Phe Tyr 
            340                 345                 350         


Ser Tyr Asp Ile Pro His Thr Cys Gly Pro Asp Pro Lys Ile Cys Cys 
        355                 360                 365             


Gln Phe Asp Phe Lys Arg Leu Pro Gly Gly Arg Phe Gly Cys Pro Trp 
    370                 375                 380                 


Gly Val Pro Pro Glu Thr Ile His Pro Gly Asn Val Gln Ser Arg Ala 
385                 390                 395                 400 


Arg Met Leu Leu Asp Gln Tyr Arg Lys Lys Ser Lys Leu Phe Arg Thr 
                405                 410                 415     


Lys Val Leu Leu Ala Pro Leu Gly Asp Asp Phe Arg Tyr Cys Glu Tyr 
            420                 425                 430         


Thr Glu Trp Asp Leu Gln Phe Lys Asn Tyr Gln Gln Leu Phe Asp Tyr 
        435                 440                 445             


Met Asn Ser Gln Ser Lys Phe Lys Val Lys Ile Gln Phe Gly Thr Leu 
    450                 455                 460                 


Ser Asp Phe Phe Asp Ala Leu Asp Lys Ala Asp Glu Thr Gln Arg Asp 
465                 470                 475                 480 


Lys Gly Gln Ser Met Phe Pro Val Leu Ser Gly Asp Phe Phe Thr Tyr 
                485                 490                 495     


Ala Asp Arg Asp Asp His Tyr Trp Ser Gly Tyr Phe Thr Ser Arg Pro 
            500                 505                 510         


Phe Tyr Lys Arg Met Asp Arg Ile Met Glu Ser His Leu Arg Ala Ala 
        515                 520                 525             


Glu Ile Leu Tyr Tyr Phe Ala Leu Arg Gln Ala His Lys Tyr Lys Ile 
    530                 535                 540                 


Asn Lys Phe Leu Ser Ser Ser Leu Tyr Thr Ala Leu Thr Glu Ala Arg 
545                 550                 555                 560 


Arg Asn Leu Gly Leu Phe Gln His His Asp Ala Ile Thr Gly Thr Ala 
                565                 570                 575     


Lys Asp Trp Val Val Val Asp Tyr Gly Thr Arg Leu Phe His Ser Leu 
            580                 585                 590         


Met Val Leu Glu Lys Ile Ile Gly Asn Ser Ala Phe Leu Leu Ile Leu 
        595                 600                 605             


Lys Asp Lys Leu Thr Tyr Asp Ser Tyr Ser Pro Asp Thr Phe Leu Glu 
    610                 615                 620                 


Met Asp Leu Lys Gln Lys Ser Gln Asp Ser Leu Pro Gln Lys Asn Ile 
625                 630                 635                 640 


Ile Arg Leu Ser Ala Glu Pro Arg Tyr Leu Val Val Tyr Asn Pro Leu 
                645                 650                 655     


Glu Gln Asp Arg Ile Ser Leu Val Ser Val Tyr Val Ser Ser Pro Thr 
            660                 665                 670         


Val Gln Val Phe Ser Ala Ser Gly Lys Pro Val Glu Val Gln Val Ser 
        675                 680                 685             


Ala Val Trp Asp Thr Ala Asn Thr Ile Ser Glu Thr Ala Tyr Glu Ile 
    690                 695                 700                 


Ser Phe Arg Ala His Ile Pro Pro Leu Gly Leu Lys Val Tyr Lys Ile 
705                 710                 715                 720 


Leu Glu Ser Ala Ser Ser Asn Ser His Leu Ala Asp Tyr Val Leu Tyr 
                725                 730                 735     


Lys Asn Lys Val Glu Asp Ser Gly Ile Phe Thr Ile Lys Asn Met Ile 
            740                 745                 750         


Asn Thr Glu Glu Gly Ile Thr Leu Glu Asn Ser Phe Val Leu Leu Arg 
        755                 760                 765             


Phe Asp Gln Thr Gly Leu Met Lys Gln Met Met Thr Lys Glu Asp Gly 
    770                 775                 780                 


Lys His His Glu Val Asn Val Gln Phe Ser Trp Tyr Gly Thr Thr Ile 
785                 790                 795                 800 


Lys Arg Asp Lys Ser Gly Ala Tyr Leu Phe Leu Pro Asp Gly Asn Ala 
                805                 810                 815     


Lys Pro Tyr Val Tyr Thr Thr Pro Pro Phe Val Arg Val Thr His Gly 
            820                 825                 830         


Arg Ile Tyr Ser Glu Val Thr Cys Phe Phe Asp His Val Thr His Arg 
        835                 840                 845             


Val Arg Leu Tyr His Ile Gln Gly Ile Glu Gly Gln Ser Val Glu Val 
    850                 855                 860                 


Ser Asn Ile Val Asp Ile Arg Lys Val Tyr Asn Arg Glu Ile Ala Met 
865                 870                 875                 880 


Lys Ile Ser Ser Asp Ile Lys Ser Gln Asn Arg Phe Tyr Thr Asp Leu 
                885                 890                 895     


Asn Gly Tyr Gln Ile Gln Pro Arg Met Thr Leu Ser Lys Leu Pro Leu 
            900                 905                 910         


Gln Ala Asn Val Tyr Pro Met Thr Thr Met Ala Tyr Ile Gln Asp Ala 
        915                 920                 925             


Lys His Arg Leu Thr Leu Leu Ser Ala Gln Ser Leu Gly Val Ser Ser 
    930                 935                 940                 


Leu Asn Ser Gly Gln Ile Glu Val Ile Met Asp Arg Arg Leu Met Gln 
945                 950                 955                 960 


Asp Asp Asn Arg Gly Leu Glu Gln Gly Ile Gln Asp Asn Lys Ile Thr 
                965                 970                 975     


Ala Asn Leu Phe Arg Ile Leu Leu Glu Lys Arg Ser Ala Val Asn Thr 
            980                 985                 990         


Glu Glu Glu Lys Lys Ser Val Ser  Tyr Pro Ser Leu Leu  Ser His Ile 
        995                 1000                 1005             


Thr Ser  Ser Leu Met Asn His  Pro Val Ile Pro Met  Ala Asn Lys 
    1010                 1015                 1020             


Phe Ser  Ser Pro Thr Leu Glu  Leu Gln Gly Glu Phe  Ser Pro Leu 
    1025                 1030                 1035             


Gln Ser  Ser Leu Pro Cys Asp  Ile His Leu Val Asn  Leu Arg Thr 
    1040                 1045                 1050             


Ile Gln  Ser Lys Val Gly Asn  Gly His Ser Asn Glu  Ala Ala Leu 
    1055                 1060                 1065             


Ile Leu  His Arg Lys Gly Phe  Asp Cys Arg Phe Ser  Ser Lys Gly 
    1070                 1075                 1080             


Thr Gly  Leu Phe Cys Ser Thr  Thr Gln Gly Lys Ile  Leu Val Gln 
    1085                 1090                 1095             


Lys Leu  Leu Asn Lys Phe Ile  Val Glu Ser Leu Thr  Pro Ser Ser 
    1100                 1105                 1110             


Leu Ser  Leu Met His Ser Pro  Pro Gly Thr Gln Asn  Ile Ser Glu 
    1115                 1120                 1125             


Ile Asn  Leu Ser Pro Met Glu  Ile Ser Thr Phe Arg  Ile Gln Leu 
    1130                 1135                 1140             


Arg 
    


<210>  149
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  149
atgttgaaag cccttttcct aactatgctg actctggcgc tggtcaagtc acaggacacc       60

gaagaaacca tcacgtacac gcaatgcact gacggatatg agtgggatcc tgtgagacag      120

caatgcaaag atattgatga atgtgacatt gtcccagacg cttgtaaagg tggaatgaag      180

tgtgtcaacc actatggagg atacctctgc cttccgaaaa cagcccagat tattgtcaat      240

aatgaacagc ctcagcagga aacacaacca gcagaaggaa cctcaggggc aaccaccggg      300

gttgtagctg ccagcagcat ggcaaccagt ggagtgttgc ccgggggtgg ttttgtggcc      360

agtgctgctg cagtcgcagg ccctgaaatg cagactggcc gaaataactt tgtcatccgg      420

cggaacccag ctgaccctca gcgcattccc tccaaccctt cccaccgtat ccagtgtgca      480

gcaggctacg agcaaagtga acacaacgtg tgccaagaca tagacgagtg cactgcaggg      540

acgcacaact gtagagcaga ccaagtgtgc atcaatttac ggggatcctt tgcatgtcag      600

tgccctcctg gatatcagaa gcgaggggag cagtgcgtag acatagatga atgtaccatc      660

cctccatatt gccaccaaag atgcgtgaat acaccaggct cattttattg ccagtgcagt      720

cctgggtttc aattggcagc aaacaactat acctgcgtag atataaatga atgtgatgcc      780

agcaatcaat gtgctcagca gtgctacaac attcttggtt cattcatctg tcagtgcaat      840

caaggatatg agctaagcag tgacaggctc aactgtgaag acattgatga atgcagaacc      900

tcaagctacc tgtgtcaata tcaatgtgtc aatgaacctg ggaaattctc atgtatgtgc      960

ccccagggat accaagtggt gagaagtaga acatgtcaag atataaatga gtgtgagacc     1020

acaaatgaat gccgggagga tgaaatgtgt tggaattatc atggcggctt ccgttgttat     1080

ccacgaaatc cttgtcaaga tccctacatt ctaacaccag agaaccgatg tgtttgccca     1140

gtctcaaatg ccatgtgccg agaactgccc cagtcaatag tctacaaata catgagcatc     1200

cgatctgata ggtctgtgcc atcagacatc ttccagatac aggccacaac tatttatgcc     1260

aacaccatca atacttttcg gattaaatct ggaaatgaaa atggagagtt ctacctacga     1320

caaacaagtc ctgtaagtgc aatgcttgtg ctcgtgaagt cattatcagg accaagagaa     1380

catatcgtgg acctggagat gctgacagtc agcagtatag ggaccttccg cacaagctct     1440

gtgttaagat tgacaataat agtggggcca ttttcatttt ag                        1482


<210>  150
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  151
<211>  2124
<212>  DNA
<213>  Homo sapiens

<400>  151
atggccgcag aggtgtattt tggcgatcta gagctcttcg agccgttcga ccacccagag       60

gagtcgattc cgaagcccgt tcacactcgc ttcaaggacg acgacggcga cgaggaggac      120

gaaaatgggg tcggcgacgc ggagctacgg gagcggcttc ggcagtgcga ggagaccatc      180

gagcagctcc gcgccgagaa tcaagaactt aaacgaaaat tgaacattct gactcgaccg      240

agtggaatat tggtgaacga tactaagtta gatggaccta tattacagat tctattcatg      300

aacaatgcta tttcaaagca atatcatcaa gaaatagagg aatttgtatc aaatttagta      360

aaaagatttg aggaacagca gaaaaatgat gtggaaaaga cttcctttaa tcttttgccc      420

cagccatcca gtattgtgct agaggaggac cacaaagtgg aagagtcctg tgccattaaa      480

aacaacaagg aagctttcag tgttgtagga agtgtcctgt attttactaa tttttgcctt      540

gataaattgg ggcaaccgct tctaaatgaa aaccctcagc tttccgaagg atgggaaata      600

cccaagtacc atcaagtctt cagccacatt gtttctctag aagggcaaga aatacaagta      660

aaggcaaaaa ggccaaagcc tcactgtttc aattgtggtt ctgaagaaca ccaaatgaaa      720

gattgcccaa tgcctcggaa tgctgctcga ataagtgaaa agagaaaaga gtatatggat      780

gcctgtggag aagcaaacaa tcagaatttc cagcagcgat accacgcaga agaagtagaa      840

gaaagatttg gaagattcaa gccaggagtt attagtgagg aacttcaaga tgcactaggt      900

gtgacagaca agagtcttcc accttttatc tatcggatgc gccagctagg gtacccacca      960

gggtggctca aagaggctga attggagaat tcggggcttg cactctatga tggaaaagat     1020

ggcactgatg gggaaacaga agttggagaa atacaacaga ataaaagtgt cacttacgat     1080

ctctcaaaat tggtcaacta tcctggtttt aatatatcta ctcccagagg aattccagac     1140

gaatggagga tctttggttc cataccaatg caggcatgtc agcagaagga tgtgtttgcc     1200

aattacctta cttctaactt ccaagcgcca ggtgtgaagt ctggcaacaa gaggtcttca     1260

tctcactcta gcccaggtag tccaaagaag cagaagaatg aaagcaactc agcgggatct     1320

cccgccgaca tggagctcga ttcagatatg gaggtaccac atggttctca gagcagcgaa     1380

agttttcagt ttcaaccacc attacctcct gacactcctc cactcccccg gggaactcct     1440

ccacccgtct tcacccctcc actcccaaag ggcaccccgc cgctgactcc cagtgactca     1500

ccccagacca gaacagcatc tggagctgtg gatgaggacg cactgactct agaagaactt     1560

gaagaacagc agaggcggat ctgggcagct cttgagcagg ccgagagcgt aaacagcgac     1620

tccgacgttc ctgtggacac acctttaact ggcaattccg ttgcctcatc accttgtcca     1680

aatgagctag acctccctgt cccggaggga aaaacatctg aaaagcagac gctggatgag     1740

cctgaggtac cagagatttt tacaaagaaa tcagaagctg gacatgcctc cagtccagac     1800

tctgaggtga catcactttg tcagaaggaa aaagcagagt tggctccggt aaacactgaa     1860

ggtgcccttc ttgataatgg cagtgtcgta ccaaactgtg acatcagcaa tgggggcagc     1920

cagaagctct ttcctgcaga caccagtcct tcaacggcca ctaaaattca tagccctata     1980

cctgacatga gcaaatttgc aactggaatc acgccatttg aatttgagaa tatggcagaa     2040

tctactggaa tgtacctcag gataagaagc ttgttaaaga actcaccccg aaaccagcag     2100

aaaaacaaaa aggcctctga ataa                                            2124


<210>  152
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ala Ala Glu Val Tyr Phe Gly Asp Leu Glu Leu Phe Glu Pro Phe 
1               5                   10                  15      


Asp His Pro Glu Glu Ser Ile Pro Lys Pro Val His Thr Arg Phe Lys 
            20                  25                  30          


Asp Asp Asp Gly Asp Glu Glu Asp Glu Asn Gly Val Gly Asp Ala Glu 
        35                  40                  45              


Leu Arg Glu Arg Leu Arg Gln Cys Glu Glu Thr Ile Glu Gln Leu Arg 
    50                  55                  60                  


Ala Glu Asn Gln Glu Leu Lys Arg Lys Leu Asn Ile Leu Thr Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Leu Val Asn Asp Thr Lys Leu Asp Gly Pro Ile Leu Gln 
                85                  90                  95      


Ile Leu Phe Met Asn Asn Ala Ile Ser Lys Gln Tyr His Gln Glu Ile 
            100                 105                 110         


Glu Glu Phe Val Ser Asn Leu Val Lys Arg Phe Glu Glu Gln Gln Lys 
        115                 120                 125             


Asn Asp Val Glu Lys Thr Ser Phe Asn Leu Leu Pro Gln Pro Ser Ser 
    130                 135                 140                 


Ile Val Leu Glu Glu Asp His Lys Val Glu Glu Ser Cys Ala Ile Lys 
145                 150                 155                 160 


Asn Asn Lys Glu Ala Phe Ser Val Val Gly Ser Val Leu Tyr Phe Thr 
                165                 170                 175     


Asn Phe Cys Leu Asp Lys Leu Gly Gln Pro Leu Leu Asn Glu Asn Pro 
            180                 185                 190         


Gln Leu Ser Glu Gly Trp Glu Ile Pro Lys Tyr His Gln Val Phe Ser 
        195                 200                 205             


His Ile Val Ser Leu Glu Gly Gln Glu Ile Gln Val Lys Ala Lys Arg 
    210                 215                 220                 


Pro Lys Pro His Cys Phe Asn Cys Gly Ser Glu Glu His Gln Met Lys 
225                 230                 235                 240 


Asp Cys Pro Met Pro Arg Asn Ala Ala Arg Ile Ser Glu Lys Arg Lys 
                245                 250                 255     


Glu Tyr Met Asp Ala Cys Gly Glu Ala Asn Asn Gln Asn Phe Gln Gln 
            260                 265                 270         


Arg Tyr His Ala Glu Glu Val Glu Glu Arg Phe Gly Arg Phe Lys Pro 
        275                 280                 285             


Gly Val Ile Ser Glu Glu Leu Gln Asp Ala Leu Gly Val Thr Asp Lys 
    290                 295                 300                 


Ser Leu Pro Pro Phe Ile Tyr Arg Met Arg Gln Leu Gly Tyr Pro Pro 
305                 310                 315                 320 


Gly Trp Leu Lys Glu Ala Glu Leu Glu Asn Ser Gly Leu Ala Leu Tyr 
                325                 330                 335     


Asp Gly Lys Asp Gly Thr Asp Gly Glu Thr Glu Val Gly Glu Ile Gln 
            340                 345                 350         


Gln Asn Lys Ser Val Thr Tyr Asp Leu Ser Lys Leu Val Asn Tyr Pro 
        355                 360                 365             


Gly Phe Asn Ile Ser Thr Pro Arg Gly Ile Pro Asp Glu Trp Arg Ile 
    370                 375                 380                 


Phe Gly Ser Ile Pro Met Gln Ala Cys Gln Gln Lys Asp Val Phe Ala 
385                 390                 395                 400 


Asn Tyr Leu Thr Ser Asn Phe Gln Ala Pro Gly Val Lys Ser Gly Asn 
                405                 410                 415     


Lys Arg Ser Ser Ser His Ser Ser Pro Gly Ser Pro Lys Lys Gln Lys 
            420                 425                 430         


Asn Glu Ser Asn Ser Ala Gly Ser Pro Ala Asp Met Glu Leu Asp Ser 
        435                 440                 445             


Asp Met Glu Val Pro His Gly Ser Gln Ser Ser Glu Ser Phe Gln Phe 
    450                 455                 460                 


Gln Pro Pro Leu Pro Pro Asp Thr Pro Pro Leu Pro Arg Gly Thr Pro 
465                 470                 475                 480 


Pro Pro Val Phe Thr Pro Pro Leu Pro Lys Gly Thr Pro Pro Leu Thr 
                485                 490                 495     


Pro Ser Asp Ser Pro Gln Thr Arg Thr Ala Ser Gly Ala Val Asp Glu 
            500                 505                 510         


Asp Ala Leu Thr Leu Glu Glu Leu Glu Glu Gln Gln Arg Arg Ile Trp 
        515                 520                 525             


Ala Ala Leu Glu Gln Ala Glu Ser Val Asn Ser Asp Ser Asp Val Pro 
    530                 535                 540                 


Val Asp Thr Pro Leu Thr Gly Asn Ser Val Ala Ser Ser Pro Cys Pro 
545                 550                 555                 560 


Asn Glu Leu Asp Leu Pro Val Pro Glu Gly Lys Thr Ser Glu Lys Gln 
                565                 570                 575     


Thr Leu Asp Glu Pro Glu Val Pro Glu Ile Phe Thr Lys Lys Ser Glu 
            580                 585                 590         


Ala Gly His Ala Ser Ser Pro Asp Ser Glu Val Thr Ser Leu Cys Gln 
        595                 600                 605             


Lys Glu Lys Ala Glu Leu Ala Pro Val Asn Thr Glu Gly Ala Leu Leu 
    610                 615                 620                 


Asp Asn Gly Ser Val Val Pro Asn Cys Asp Ile Ser Asn Gly Gly Ser 
625                 630                 635                 640 


Gln Lys Leu Phe Pro Ala Asp Thr Ser Pro Ser Thr Ala Thr Lys Ile 
                645                 650                 655     


His Ser Pro Ile Pro Asp Met Ser Lys Phe Ala Thr Gly Ile Thr Pro 
            660                 665                 670         


Phe Glu Phe Glu Asn Met Ala Glu Ser Thr Gly Met Tyr Leu Arg Ile 
        675                 680                 685             


Arg Ser Leu Leu Lys Asn Ser Pro Arg Asn Gln Gln Lys Asn Lys Lys 
    690                 695                 700                 


Ala Ser Glu 
705         


<210>  153
<211>  3477
<212>  DNA
<213>  Homo sapiens

<400>  153
atggagtcag gccacctcct ctgggctctg ctgttcatgc agtccttgtg gcctcaactg       60

actgatggag ccactcgagt ctactacctg ggcatccggg atgtgcagtg gaactatgct      120

cccaagggaa gaaatgtcat cacgaaccag cctctggaca gtgacatagt ggcttccagc      180

ttcttaaagt ctgacaagaa ccggataggg ggaacctaca agaagaccat ctataaagaa      240

tacaaggatg actcatacac agatgaagtg gcccagcctg cctggttggg cttcctgggg      300

ccagtgttgc aggctgaagt gggggatgtc attcttattc acctgaagaa ttttgccact      360

cgtccctata ccatccaccc tcatggtgtc ttctacgaga aggactctga aggttcccta      420

tacccagatg gctcctctgg gccactgaaa gctgatgact ctgttccccc ggggggcagc      480

catatctaca actggaccat tccagaaggc catgcaccca ccgatgctga cccagcgtgc      540

ctcacctgga tctaccattc tcatgtagat gctccacgag acattgcaac tggcctaatt      600

gggcctctca tcacctgtaa aagaggagcc ctggatggga actcccctcc tcaacgccag      660

gatacagacc atgatttctt cctcctcttc agtgtggtag atgagaacct cagctggcat      720

ctcaatgaga acattgccac ttactgctca gatcctgctt cagtggacaa agaagatgag      780

acatttcagg agagcaatag gatgcatgca atcaatggct ttgtttttgg gaatttacct      840

gagctgaaca tgtgtgcaca gaaacgtgtg gcctggcact tgtttggcat gggcaatgaa      900

attgatgtcc acacagcatt tttccatgga cagatgctga ctacccgtgg acaccacact      960

gatgtggcta acatctttcc agccaccttt gtgactgctg agatggtgcc ctgggaacct     1020

ggtacctggt taattagctg ccaagtgaac agtcactttc gagatggcat gcaggcactc     1080

tacaaggtca agtcttgctc catggcccct cctgtggacc tgctcacagg caaagttcga     1140

cagtacttca ttgaggccca tgagattcaa tgggactatg gcccgatggg gcatgatggg     1200

agtactggga agaatttgag agagccaggc agtatctcag ataagttttt ccagaagagc     1260

tccagccgaa ttgggggcac ttactggaaa gtgcgatatg aagcctttca agatgagaca     1320

ttccaagaga agatgcattt ggaggaagat aggcatcttg gaatcctggg gccagtgatc     1380

cgggctgagg tgggtgacac cattcaggtg gtcttctaca accgtgcctc ccagccattc     1440

agcatgcagc cccatggggt cttttatgag aaagactatg aaggcactgt gtacaatgat     1500

ggctcatctt accctggctt ggttgccaag ccctttgaga aagtaacata ccgctggaca     1560

gtcccccctc atgccggtcc cactgctcag gatcctgctt gtctcacttg gatgtacttc     1620

tctgctgcag atcccataag agacacaaat tctggcctgg tgggcccgct gctggtgtgc     1680

agggctggtg ccttgggtgc agatggcaag cagaaagggg tggataaaga attctttctt     1740

ctcttcactg tgttggatga gaacaagagc tggtacagca atgccaatca agcagctgct     1800

atgttggatt tccgactgct ttcagaggat attgagggct tccaagactc caatcggatg     1860

catgccatta atgggtttct gttctctaac ctgcccaggc tggacatgtg caagggtgac     1920

acagtggcct ggcacctgct cggcctgggc acagagactg atgtgcatgg agtcatgttc     1980

cagggcaaca ctgtgcagct tcagggcatg aggaagggtg cagctatgct ctttcctcat     2040

acctttgtca tggccatcat gcagcctgac aaccttggga catttgagat ttattgccag     2100

gcaggcagcc atcgagaagc agggatgagg gcaatctata atgtctccca gtgtcctggc     2160

caccaagcca cccctcgcca acgctaccaa gctgcaagaa tctactatat catggcagaa     2220

gaagtagagt gggactattg ccctgaccgg agctgggaac gggaatggca caaccagtct     2280

gagaaggaca gttatggtta cattttcctg agcaacaagg atgggctcct gggttccaga     2340

tacaagaaag ctgtattcag ggaatacact gatggtacat tcaggatccc tcggccaagg     2400

actggaccag aagaacactt gggaatcttg ggtccactta tcaaaggtga agttggtgat     2460

atcctgactg tggtattcaa gaataatgcc agccgcccct actctgtgca tgctcatgga     2520

gtgctagaat ctactactgt ctggccactg gctgctgagc ctggtgaggt ggtcacttat     2580

cagtggaaca tcccagagag gtctggccct gggcccaatg actctgcttg tgtttcctgg     2640

atctattatt ctgcagtgga tcccatcaag gacatgtata gtggcctggt ggggcccttg     2700

gctatctgcc aaaagggcat cctggagccc catggaggac ggagtgacat ggatcgggaa     2760

tttgcattgt tgttcttgat ttttgatgaa aataagtctt ggtatttgga ggaaaatgtg     2820

gcaacccatg ggtcccagga tccaggcagt attaacctac aggatgaaac tttcttggag     2880

agcaataaaa tgcatgcaat caatgggaaa ctctatgcca accttagggg tcttaccatg     2940

taccaaggag aacgagtggc ctggtacatg ctggccatgg gccaagatgt ggatctacac     3000

accatccact ttcatgcaga gagcttcctc tatcggaatg gcgagaacta ccgggcagat     3060

gtggtggatc tgttcccagg gacttttgag gttgtggaga tggtggccag caaccctggg     3120

acatggctga tgcactgcca tgtgactgac catgtccatg ctggcatgga gaccctcttc     3180

actgtttttt ctcgaacaga acacttaagc cctctcaccg tcatcaccaa agagactgaa     3240

aaagcagtgc cccccagaga cattgaagaa ggcaatgtga agatgctggg catgcagatc     3300

cccataaaga atgttgagat gctggcctct gttttggttg ccattagtgt cacccttctg     3360

ctcgttgttc tggctcttgg tggagtggtt tggtaccaac atcgacagag aaagctacga     3420

cgcaatagga ggtccatcct ggatgacagc ttcaagcttc tgtctttcaa acagtaa        3477


<210>  154
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met Gln Ser Leu 
1               5                   10                  15      


Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr Leu Gly Ile 
            20                  25                  30          


Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn Val Ile Thr 
        35                  40                  45              


Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe Leu Lys Ser 
    50                  55                  60                  


Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile Tyr Lys Glu 
65                  70                  75                  80  


Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro Ala Trp Leu 
                85                  90                  95      


Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp Val Ile Leu 
            100                 105                 110         


Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile His Pro His 
        115                 120                 125             


Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr Pro Asp Gly 
    130                 135                 140                 


Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro Gly Gly Ser 
145                 150                 155                 160 


His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro Thr Asp Ala 
                165                 170                 175     


Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val Asp Ala Pro 
            180                 185                 190         


Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr Cys Lys Arg 
        195                 200                 205             


Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp Thr Asp His 
    210                 215                 220                 


Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu Ser Trp His 
225                 230                 235                 240 


Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala Ser Val Asp 
                245                 250                 255     


Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His Ala Ile Asn 
            260                 265                 270         


Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys Ala Gln Lys 
        275                 280                 285             


Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile Asp Val His 
    290                 295                 300                 


Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly His His Thr 
305                 310                 315                 320 


Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala Glu Met Val 
                325                 330                 335     


Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val Asn Ser His 
            340                 345                 350         


Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser Cys Ser Met 
        355                 360                 365             


Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln Tyr Phe Ile 
    370                 375                 380                 


Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly His Asp Gly 
385                 390                 395                 400 


Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser Asp Lys Phe 
                405                 410                 415     


Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp Lys Val Arg 
            420                 425                 430         


Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met His Leu Glu 
        435                 440                 445             


Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg Ala Glu Val 
    450                 455                 460                 


Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser Gln Pro Phe 
465                 470                 475                 480 


Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr Glu Gly Thr 
                485                 490                 495     


Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu Val Ala Lys Pro Phe 
            500                 505                 510         


Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro His Ala Gly Pro Thr 
        515                 520                 525             


Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr Phe Ser Ala Ala Asp 
    530                 535                 540                 


Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly Pro Leu Leu Val Cys 
545                 550                 555                 560 


Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln Lys Gly Val Asp Lys 
                565                 570                 575     


Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu Asn Lys Ser Trp Tyr 
            580                 585                 590         


Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp Phe Arg Leu Leu Ser 
        595                 600                 605             


Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg Met His Ala Ile Asn 
    610                 615                 620                 


Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp Met Cys Lys Gly Asp 
625                 630                 635                 640 


Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr Glu Thr Asp Val His 
                645                 650                 655     


Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu Gln Gly Met Arg Lys 
            660                 665                 670         


Gly Ala Ala Met Leu Phe Pro His Thr Phe Val Met Ala Ile Met Gln 
        675                 680                 685             


Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys Gln Ala Gly Ser His 
    690                 695                 700                 


Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln Cys Pro Gly 
705                 710                 715                 720 


His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg Ile Tyr Tyr 
                725                 730                 735     


Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp Arg Ser Trp 
            740                 745                 750         


Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr Gly Tyr Ile 
        755                 760                 765             


Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr Lys Lys Ala 
    770                 775                 780                 


Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro Arg Pro Arg 
785                 790                 795                 800 


Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu Ile Lys Gly 
                805                 810                 815     


Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn Ala Ser Arg 
            820                 825                 830         


Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr Thr Val Trp 
        835                 840                 845             


Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln Trp Asn Ile 
    850                 855                 860                 


Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys Val Ser Trp 
865                 870                 875                 880 


Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr Ser Gly Leu 
                885                 890                 895     


Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu Pro His Gly 
            900                 905                 910         


Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe Leu Ile Phe 
        915                 920                 925             


Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala Thr His Gly 
    930                 935                 940                 


Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr Phe Leu Glu 
945                 950                 955                 960 


Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala Asn Leu Arg 
                965                 970                 975     


Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr Met Leu Ala 
            980                 985                 990         


Met Gly Gln Asp Val Asp Leu His  Thr Ile His Phe His  Ala Glu Ser 
        995                 1000                 1005             


Phe Leu  Tyr Arg Asn Gly Glu  Asn Tyr Arg Ala Asp  Val Val Asp 
    1010                 1015                 1020             


Leu Phe  Pro Gly Thr Phe Glu  Val Val Glu Met Val  Ala Ser Asn 
    1025                 1030                 1035             


Pro Gly  Thr Trp Leu Met His  Cys His Val Thr Asp  His Val His 
    1040                 1045                 1050             


Ala Gly  Met Glu Thr Leu Phe  Thr Val Phe Ser Arg  Thr Glu His 
    1055                 1060                 1065             


Leu Ser  Pro Leu Thr Val Ile  Thr Lys Glu Thr Glu  Lys Ala Val 
    1070                 1075                 1080             


Pro Pro  Arg Asp Ile Glu Glu  Gly Asn Val Lys Met  Leu Gly Met 
    1085                 1090                 1095             


Gln Ile  Pro Ile Lys Asn Val  Glu Met Leu Ala Ser  Val Leu Val 
    1100                 1105                 1110             


Ala Ile  Ser Val Thr Leu Leu  Leu Val Val Leu Ala  Leu Gly Gly 
    1115                 1120                 1125             


Val Val  Trp Tyr Gln His Arg  Gln Arg Lys Leu Arg  Arg Asn Arg 
    1130                 1135                 1140             


Arg Ser  Ile Leu Asp Asp Ser  Phe Lys Leu Leu Ser  Phe Lys Gln 
    1145                 1150                 1155             


<210>  155
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  155
atgactactc agttgccagc ttacgtggca attttgcttt tctatgtctc aagagccagc       60

tgccaggaca ctttcactgc agctgtttat gagcatgcag cgatattgcc caatgccacc      120

ctaacaccag tgtctcgtga ggaggctttg gcattaatga atcggaatct ggacattttg      180

gaaggagcga tcacatcagc agcagatcag ggtgcgcata ttattgtgac tccagaagat      240

gctatttatg gctggaactt caacagggac tctctctacc catatttgga ggacatccca      300

gaccctgaag taaactggat cccctgtaat aatcgtaaca gatttggcca gaccccagta      360

caagaaagac tcagctgcct ggccaagaac aactctatct atgttgtggc aaatattggg      420

gacaagaagc catgcgatac cagtgatcct cagtgtcccc ctgatggccg ttaccaatac      480

aacactgatg tggtatttga ttctcaagga aaactggtgg cacgctacca taagcaaaac      540

cttttcatgg gtgaaaatca attcaatgta cccaaggagc ctgagattgt gactttcaat      600

accacctttg gaagttttgg cattttcaca tgctttgata tactcttcca tgatcctgct      660

gttaccttgg tgaaagattt ccacgtggac accatagtat tcccaacagc ttggatgaat      720

gttttgccac atttgtcagc tgttgaattc cactcagctt gggctatggg catgagggtc      780

aatttccttg catccaacat acattacccc tcaaagaaaa tgacaggaag tggcatctat      840

gcacccaatt cttcaagagc atttcattat gatatgaaga cagaagaggg aaaactcctc      900

ctctcgcaac tggattccca cccatcccat tctgcagtgg tgaactggac ttcctatgcc      960

agcagtatag aagcgctctc atcaggaaac aaggaattta aaggcactgt ctttttcgat     1020

gaattcactt ttgtgaagct cacaggagtt gcaggaaatt atacagtttg tcagaaagat     1080

ctctgctgtc atttaagcta caaaatgtct gagaacatac caaatgaagt gtacgctcta     1140

ggggcatttg acggactgca cactgtggaa gggcgctatt atctacagat ttgtaccctg     1200

ttgaaatgta aaacgactaa tttaaacact tgcggtgact cagctgaaac agcttctacc     1260

aggtttgaaa tgttctccct cagtggcact ttcggaaccc agtatgtctt tcctgaggtg     1320

ttgctgagtg aaaatcagct tgcacctgga gaatttcagg tgtcaactga cggacgcttg     1380

tttagtctga agccaacatc cggacctgtc ttaacagtaa ctctgtttgg gaggttgtat     1440

gagaaggact gggcatcaaa tgcttcatca ggcctcacag cacaagcaag aataataatg     1500

ctaatagtta tagcacctat tgtatgctca ttaagttggt ag                        1542


<210>  156
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Thr Thr Gln Leu Pro Ala Tyr Val Ala Ile Leu Leu Phe Tyr Val 
1               5                   10                  15      


Ser Arg Ala Ser Cys Gln Asp Thr Phe Thr Ala Ala Val Tyr Glu His 
            20                  25                  30          


Ala Ala Ile Leu Pro Asn Ala Thr Leu Thr Pro Val Ser Arg Glu Glu 
        35                  40                  45              


Ala Leu Ala Leu Met Asn Arg Asn Leu Asp Ile Leu Glu Gly Ala Ile 
    50                  55                  60                  


Thr Ser Ala Ala Asp Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp 
65                  70                  75                  80  


Ala Ile Tyr Gly Trp Asn Phe Asn Arg Asp Ser Leu Tyr Pro Tyr Leu 
                85                  90                  95      


Glu Asp Ile Pro Asp Pro Glu Val Asn Trp Ile Pro Cys Asn Asn Arg 
            100                 105                 110         


Asn Arg Phe Gly Gln Thr Pro Val Gln Glu Arg Leu Ser Cys Leu Ala 
        115                 120                 125             


Lys Asn Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro 
    130                 135                 140                 


Cys Asp Thr Ser Asp Pro Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr 
145                 150                 155                 160 


Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Val Ala Arg Tyr 
                165                 170                 175     


His Lys Gln Asn Leu Phe Met Gly Glu Asn Gln Phe Asn Val Pro Lys 
            180                 185                 190         


Glu Pro Glu Ile Val Thr Phe Asn Thr Thr Phe Gly Ser Phe Gly Ile 
        195                 200                 205             


Phe Thr Cys Phe Asp Ile Leu Phe His Asp Pro Ala Val Thr Leu Val 
    210                 215                 220                 


Lys Asp Phe His Val Asp Thr Ile Val Phe Pro Thr Ala Trp Met Asn 
225                 230                 235                 240 


Val Leu Pro His Leu Ser Ala Val Glu Phe His Ser Ala Trp Ala Met 
                245                 250                 255     


Gly Met Arg Val Asn Phe Leu Ala Ser Asn Ile His Tyr Pro Ser Lys 
            260                 265                 270         


Lys Met Thr Gly Ser Gly Ile Tyr Ala Pro Asn Ser Ser Arg Ala Phe 
        275                 280                 285             


His Tyr Asp Met Lys Thr Glu Glu Gly Lys Leu Leu Leu Ser Gln Leu 
    290                 295                 300                 


Asp Ser His Pro Ser His Ser Ala Val Val Asn Trp Thr Ser Tyr Ala 
305                 310                 315                 320 


Ser Ser Ile Glu Ala Leu Ser Ser Gly Asn Lys Glu Phe Lys Gly Thr 
                325                 330                 335     


Val Phe Phe Asp Glu Phe Thr Phe Val Lys Leu Thr Gly Val Ala Gly 
            340                 345                 350         


Asn Tyr Thr Val Cys Gln Lys Asp Leu Cys Cys His Leu Ser Tyr Lys 
        355                 360                 365             


Met Ser Glu Asn Ile Pro Asn Glu Val Tyr Ala Leu Gly Ala Phe Asp 
    370                 375                 380                 


Gly Leu His Thr Val Glu Gly Arg Tyr Tyr Leu Gln Ile Cys Thr Leu 
385                 390                 395                 400 


Leu Lys Cys Lys Thr Thr Asn Leu Asn Thr Cys Gly Asp Ser Ala Glu 
                405                 410                 415     


Thr Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser Gly Thr Phe Gly 
            420                 425                 430         


Thr Gln Tyr Val Phe Pro Glu Val Leu Leu Ser Glu Asn Gln Leu Ala 
        435                 440                 445             


Pro Gly Glu Phe Gln Val Ser Thr Asp Gly Arg Leu Phe Ser Leu Lys 
    450                 455                 460                 


Pro Thr Ser Gly Pro Val Leu Thr Val Thr Leu Phe Gly Arg Leu Tyr 
465                 470                 475                 480 


Glu Lys Asp Trp Ala Ser Asn Ala Ser Ser Gly Leu Thr Ala Gln Ala 
                485                 490                 495     


Arg Ile Ile Met Leu Ile Val Ile Ala Pro Ile Val Cys Ser Leu Ser 
            500                 505                 510         


Trp 
    


<210>  157
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  157
atgggtgtga aggcgtctca aacaggcttt gtggtcctgg tgctgctcca gtgctgctct       60

gcatacaaac tggtctgcta ctacaccagc tggtcccagt accgggaagg cgatgggagc      120

tgcttcccag atgcccttga ccgcttcctc tgtacccaca tcatctacag ctttgccaat      180

ataagcaacg atcacatcga cacctgggag tggaatgatg tgacgctcta cggcatgctc      240

aacacactca agaacaggaa ccccaacctg aagactctct tgtctgtcgg aggatggaac      300

tttgggtctc aaagattttc caagatagcc tccaacaccc agagtcgccg gactttcatc      360

aagtcagtac cgccatttct gcgcacccat ggctttgatg ggctggacct tgcctggctc      420

taccctggac ggagagacaa acagcatttt accaccctaa tcaaggaaat gaaggccgaa      480

tttataaagg aagcccagcc agggaaaaag cagctcctgc tcagcgcagc actgtctgcg      540

gggaaggtca ccattgacag cagctatgac attgccaaga tatcccaaca cctggatttc      600

attagcatca tgacctacga ttttcatgga gcctggcgtg ggaccacagg ccatcacagt      660

cccctgttcc gaggtcagga ggatgcaagt cctgacagat tcagcaacac tgactatgct      720

gtggggtaca tgttgaggct gggggctcct gccagtaagc tggtgatggg catccccacc      780

ttcgggagga gcttcactct ggcttcttct gagactggtg ttggagcccc aatctcagga      840

ccgggaattc caggccggtt caccaaggag gcagggaccc ttgcctacta tgagatctgt      900

gacttcctcc gcggagccac agtccataga atcctcggcc agcaggtccc ctatgccacc      960

aagggcaacc agtgggtagg atacgacgac caggaaagcg tcaaaagcaa ggtgcagtac     1020

ctgaaggaca ggcagctggc gggcgccatg gtatgggccc tggacctgga tgacttccag     1080

ggctccttct gtggccagga tctgcgcttc cctctcacca atgccatcaa ggatgcactc     1140

gctgcaacgt ag                                                         1152


<210>  158
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  159
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  159
atggcagaca aagttaggag gcagaggccg aggaggcgag tctgttgggc cttggtggct       60

gtgctcttgg cagacctgtt ggcactgagt gatacactgg cagtgatgtc tgtggacctg      120

ggcagtgagt ccatgaaggt ggccattgtc aaacctggag tgcccatgga aattgtcttg      180

aataaggaat ctcggaggaa aacaccggtg atcgtgaccc tgaaagaaaa tgaaagattc      240

tttggagaca gtgcagcaag catggcgatt aagaatccaa aggctacgct acgttacttc      300

cagcacctcc tggggaagca ggcagataac ccccatgtag ctctttacca ggcccgcttc      360

ccggagcacg agctgacttt cgacccacag aggcagactg tgcactttca gatcagctcg      420

cagctgcagt tctcacctga ggaagtgttg ggcatggttc tcaattattc tcgttctcta      480

gctgaagatt ttgcagagca gcccatcaag gatgcagtga tcaccgtgcc agtcttcttc      540

aaccaggccg agcgccgagc tgtgctgcag gctgctcgta tggctggcct caaagtgctg      600

cagctcatca atgacaacac cgccactgcc ctcagctatg gtgtcttccg ccggaaagat      660

attaacacca ctgcccagaa tatcatgttc tatgacatgg gctcaggcag caccgtatgc      720

accattgtga cctaccagat ggtgaagact aaggaagctg ggatgcagcc acagctgcag      780

atccggggag taggatttga ccgtaccctg gggggcctgg agatggagct ccggcttcga      840

gaacgcctgg ctgggctttt caatgagcag cgcaagggtc agagagcaaa ggatgtgcgg      900

gagaacccgc gtgccatggc caagctgctg cgtgaggcta atcggctcaa aaccgtcctc      960

agtgccaacg ctgaccacat ggcacagatt gaaggcctga tggatgatgt ggacttcaag     1020

gcaaaagtga ctcgtgtgga atttgaggag ttgtgtgcag acttgtttga gcgggtgcct     1080

gggcctgtac agcaggccct ccagagtgcc gaaatgagtc tggatgagat tgagcaggtg     1140

atcctggtgg gtggggccac tcgggtcccc agagttcagg aggtgctgct gaaggccgtg     1200

ggcaaggagg agctggggaa gaacatcaat gcagatgaag cagccgccat gggggcagtg     1260

taccaggcag ctgcgctcag caaagccttt aaagtgaagc catttgtcgt ccgagatgca     1320

gtggtctacc ccatcctggt ggagttcacg agggaggtgg aggaggagcc tgggattcac     1380

agcctgaagc acaataaacg ggtactcttc tctcggatgg ggccctaccc tcaacgcaaa     1440

gtcatcacct ttaaccgcta cagccatgat ttcaacttcc acatcaacta cggcgacctg     1500

ggcttcctgg ggcctgaaga tcttcgggta tttggctccc agaatctgac cacagtgaag     1560

ctaaaagggg tgggtgacag cttcaagaag tatcctgact acgagtccaa gggcatcaag     1620

gctcacttca acctggatga gagtggcgtg ctcagtctag acagggtgga gtctgtattt     1680

gagacactgg tagaggacag cgcagaagag gaatctactc tcaccaaact tggcaacacc     1740

atttccagcc tgtttggagg cggtaccaca ccagatgcca aggagaatgg tactgatact     1800

gtccaggagg aagaggagag ccctgcagag gggagcaagg acgagcctgg ggagcaggtg     1860

gagctcaagg aggaagctga ggccccagtg gaggatggct ctcagccccc accccctgaa     1920

cctaagggag atgcaacccc tgagggagaa aaggccacag aaaaagaaaa tggggacaag     1980

tctgaggccc agaaaccaag tgagaaggca gaggcagggc ctgagggcgt cgctccagcc     2040

ccagagggag agaagaagca gaagcccgcc aggaagcggc gaatggtaga ggagatcggg     2100

gtggagctgg ttgttctgga cctgcctgac ttgccagagg ataagctggc tcagtcggtg     2160

cagaaacttc aggacttgac actccgagac ctggagaagc aggaacggga aaaagctgcc     2220

aacagcttgg aagcattcat atttgagacc caggacaagc tgtaccagcc cgagtaccag     2280

gaagtgtcca cagaggagca gcgtgaggag atctctggga agctcagcgc cgcatccacc     2340

tggctggagg atgagggtgt tggagccacc acagtgatgt tgaaggagaa gctggctgag     2400

ctgaggaagc tgtgccaagg gctgtttttt cgggtagagg agcgcaagaa gtggcccgaa     2460

cggctgtctg ccctcgataa tctcctcaac cattccagca tgttcctcaa gggggcccgg     2520

ctcatcccag agatggacca gatcttcact gaggtggaga tgacaacgtt agagaaagtc     2580

atcaatgaga cctgggcctg gaagaatgca actctggccg agcaggctaa gctgcccgcc     2640

acagagaagc ctgtgttgct ctcaaaagac attgaagcta agatgatggc cctggaccga     2700

gaggtgcagt atctgctcaa taaggccaag tttaccaagc cccggccccg gcctaaggac     2760

aagaatggga cccgggcaga gccacccctc aatgccagtg ccagtgacca gggggagaag     2820

gtcatccctc cagcaggcca gactgaagat gcagagccca tttcagaacc tgagaaagta     2880

gagactggat ccgagccagg agacactgag cctttggagt taggaggtcc tggagcagaa     2940

cctgaacaga aagaacaatc gacaggacag aagcggcctt tgaagaacga cgaactataa     3000


<210>  160
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  161
<211>  3054
<212>  DNA
<213>  Homo sapiens

<400>  161
atgccggtca tgaaggggtt gctggccccg caaaacacct tcctggacac catcgccacc       60

cgttttgacg gaacgcacag caacttcctg ctggccaacg cacagggcac acggggcttt      120

cccatcgtct actgctccga cggcttctgc gagctcacag gctacggtcg caccgaggtc      180

atgcagaaga cctgcagctg ccgtttcctc tacggcccag agaccagtga gccagccctg      240

cagcgtctgc acaaagccct ggagggccac caggagcacc gggctgaaat ctgcttctac      300

cgcaaggatg gctcagcctt ttggtgcctc ctggacatga tgcccatcaa gaatgagatg      360

ggggaggtcg tgctgttcct cttttccttc aaggatatca ctcagagtgg aagcccagga      420

cttggccccc aaggaggccg cggggacagt aatcacgaaa actcccttgg tagaagggga      480

gccacctgga aatttcggtc tgccagaaga cggagccgta ctgtcctaca ccgactgacc      540

ggccactttg gccgccgggg ccagggaggc atgaaggcca ataataacgt gtttgagcca      600

aagccatcag tgcccgagta caaggtggcc tccgtggggg ggtctcgctg cctcctcctc      660

cactacagcg tctccaaggc catctgggac ggccttatcc tccttgccac cttctacgtt      720

gcggtcaccg tcccctacaa tgtctgtttc tcgggtgacg atgacacccc catcacttcg      780

cgacacaccc ttgtcagcga catcgccgtg gaaatgctct tcatcctaga tatcatcctg      840

aacttccgca ccacctatgt gtcccagtcc ggccaggtaa tctctgctcc tcgttccatt      900

ggcctccact acctggccac ctggttcttc atcgacctta ttgctgctct gccctttgac      960

ctgctttaca tcttcaacat caccgtgacc tcgctggtgc acctactgaa gacagtgcgg     1020

ctgttgcggc tgctgcggct gctgcagaag ctggagcggt actctcagtg cagtgctgtg     1080

gtgctcacgc tgctcatgtc ggtctttgcg ctccttgccc actggatggc ctgcatctgg     1140

tatgtcatcg ggcgccggga gatggaggcc aatgacccgc tgctctggga cattggctgg     1200

ttgcatgagt tgggcaagcg tctggaggtg ccctatgtca atggctcggt gggcggccca     1260

tcacggcgca gcgcctacat cgcggcactg tacttcactc taagcagcct caccagtgtg     1320

ggctttggca acgtgtgtgc caacaccgac gcggagaaga tcttctccat ctgcacgatg     1380

ctcataggcg ccctgatgca cgctgtggtg ttcgggaacg tgacagccat catccagcgc     1440

atgtactcgc gccgctcgct ctaccacagc cgcatgaagg acctcaagga cttcatccgt     1500

gtgcaccgcc tgccgcggcc gctcaagcag cgcatgctcg aatacttcca gaccacgtgg     1560

gccgtcaaca gcggcatcga cgccaacgag ttactgcgtg acttcccaga cgagctgaga     1620

gctgacattg ctatgcacct gaatcgggag atcctgcagc tgccgttgtt cggggcagcg     1680

agcaggggct gcctgcgggc cctatcgctg cacatcaaga cctcgttctg cgctccgggc     1740

gagtacctgt tgcgccgtgg ggatgccctg caggcacatt actatgtctg ctccggctcg     1800

cttgaggtgc tccgagacaa catggtgctg gccatcctgg ggaaggggga cctgattgga     1860

gcagatatcc ctgagccggg gcaggagcct gggttgggag cagacccaaa cttcgtgcta     1920

aagaccagtg ctgatgtgaa agctctgacc tactgtggcc tgcagcagct gagcagccga     1980

gggctggctg aggtcctgag gctctatcct gagtatgggg ctgccttccg ggctggcctg     2040

ccccgggacc tcaccttcaa cctgcgccag ggctctgaca ccagtggcct cagccgcttt     2100

tcccgatccc ctcgcctctc ccagccccgc tcagaaagcc tcggctcctc ctcagacaag     2160

acgctgccat ccatcacaga ggccgagagt ggcgcggagc ctgggggtgg tcccaggccc     2220

cgacggcccc tcctgctgcc caacctcagc ccagcacggc ctcggggctc cctggtcagc     2280

cttttgggcg aggagctgcc cccattctca gcccttgtct cctctccttc cttatcccca     2340

tccctgtccc ctgccctggc tggccagggc cacagtgcct cccctcacgg cccccccagg     2400

tgctctgctg cctggaagcc ccctcagctt ctcattcccc cactgggaac ctttggacct     2460

ccggacctca gtccccggat agtggatggc attgaggact ctggcagcac agctgaggcc     2520

ccttcattcc gattcagcag gaggcctgaa ctgccaaggc cccgctccca ggcgccccct     2580

acagggacca ggcccagccc agaattggcc agtgaggctg aggaggtgaa ggaaaaggtt     2640

tgccggctga accaggagat ctctcgtctc aatcaggagg tgtctcagct tagccgggag     2700

ctgcggcaca tcatgggcct gctgcaggcc aggctgggtc ccccaggcca cccagcaggc     2760

tccgcttgga ccccagaccc tccttgtcca cagctgaggc caccatgcct ctctccttgt     2820

gcgtccagac caccacccag cctccaggat actacgcttg ctgaagttca ctgcccagcc     2880

agtgtgggga ccatggagac agggactgcg ctcctggact tgagaccttc catattgccc     2940

ccctacccct cagagcctga ccctctggga ccctctccag tgccagaggc ctcaccccca     3000

accccaagcc tcttgaggca cagtttccag tccaggtcag acacgttcca ctga           3054


<210>  162
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala 
            20                  25                  30          


Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr 
    50                  55                  60                  


Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu 
65                  70                  75                  80  


Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu 
                85                  90                  95      


Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln 
    130                 135                 140                 


Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly 
145                 150                 155                 160 


Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu 
                165                 170                 175     


His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys 
            180                 185                 190         


Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys 
        195                 200                 205             


Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val 
    210                 215                 220                 


Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val 
225                 230                 235                 240 


Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr 
                245                 250                 255     


Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met 
            260                 265                 270         


Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser 
        275                 280                 285             


Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr 
    290                 295                 300                 


Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu 
                325                 330                 335     


Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu 
            340                 345                 350         


Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val 
        355                 360                 365             


Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly 
    370                 375                 380                 


Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp 
385                 390                 395                 400 


Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser 
                405                 410                 415     


Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe 
            420                 425                 430         


Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn 
        435                 440                 445             


Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala 
    450                 455                 460                 


Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg 
465                 470                 475                 480 


Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys 
                485                 490                 495     


Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met 
            500                 505                 510         


Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala 
        515                 520                 525             


Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala 
    530                 535                 540                 


Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala 
545                 550                 555                 560 


Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe 
                565                 570                 575     


Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala 
            580                 585                 590         


His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met 
        595                 600                 605             


Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro 
    610                 615                 620                 


Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu 
625                 630                 635                 640 


Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln 
                645                 650                 655     


Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr 
            660                 665                 670         


Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu 
        675                 680                 685             


Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro 
    690                 695                 700                 


Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys 
705                 710                 715                 720 


Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly 
                725                 730                 735     


Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala 
            740                 745                 750         


Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro 
        755                 760                 765             


Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro 
    770                 775                 780                 


Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg 
785                 790                 795                 800 


Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly 
                805                 810                 815     


Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu 
            820                 825                 830         


Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg 
        835                 840                 845             


Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg 
    850                 855                 860                 


Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val 
865                 870                 875                 880 


Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln 
                885                 890                 895     


Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu 
            900                 905                 910         


Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro 
        915                 920                 925             


Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro 
    930                 935                 940                 


Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala 
945                 950                 955                 960 


Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro 
                965                 970                 975     


Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser 
            980                 985                 990         


Pro Val Pro Glu Ala Ser Pro Pro  Thr Pro Ser Leu Leu  Arg His Ser 
        995                 1000                 1005             


Phe Gln  Ser Arg Ser Asp Thr  Phe His 
    1010                 1015         


<210>  163
<211>  1746
<212>  DNA
<213>  Homo sapiens

<400>  163
atggagaggg acagccacgg gaatgcatct ccagcaagaa caccttcagc tggagcatct       60

ccagcccagg catctccagc tgggacacct ccaggccggg catctccagc ccaggcatct      120

ccagcccagg catctccagc tgggacacct ccgggccggg catctccagc ccaggcatct      180

ccagctggta cacctccagg ccgggcatct ccaggccggg catctccagc ccaggcatct      240

ccagcccggg catctccggc tctggcatca ctttccaggt cctcatccgg caggtcatca      300

tccgccaggt cagcctcggt gacaacctcc ccaaccagag tgtaccttgt tagagcaaca      360

ccagtggggg ctgtacccat ccgatcatct cctgccaggt cagcaccagc aaccagggcc      420

accagggaga gcccaggtac gagcctgccc aagttcacct ggcgggaggg ccagaagcag      480

ctaccgctca tcgggtgcgt gctcctcctc attgccctgg tggtttcgct catcatcctc      540

ttccagttct ggcagggcca cacagggatc aggcacaagg agcagaggga gagctgtccc      600

aagcacgctg ttcgctgtga cggggtggtg gactgcaagc tgaagagtga cgagctgggc      660

tgcgtgaggt ttgactggga caagtctctg cttaaaatct actctgggtc ctcccatcag      720

tggcttccca tctgtagcag caactggaat gactcctact cagagaagac ctgccagcag      780

ctgggtttcg agagtgctca ccggacaacc gaggttgccc acagggattt tgccaacagc      840

ttctcaatct tgagatacaa ctccaccatc caggaaagcc tccacaggtc tgaatgccct      900

tcccagcggt atatctccct ccagtgttcc cactgcggac tgagggccat gaccgggcgg      960

atcgtgggag gggcgctggc ctcggatagc aagtggcctt ggcaagtgag tctgcacttc     1020

ggcaccaccc acatctgtgg aggcacgctc attgacgccc agtgggtgct cactgccgcc     1080

cactgcttct tcgtgacccg ggagaaggtc ctggagggct ggaaggtgta cgcgggcacc     1140

agcaacctgc accagttgcc tgaggcagcc tccattgccg agatcatcat caacagcaat     1200

tacaccgatg aggaggacga ctatgacatc gccctcatgc ggctgtccaa gcccctgacc     1260

ctgtccgctc acatccaccc tgcttgcctc cccatgcatg gacagacctt tagcctcaat     1320

gagacctgct ggatcacagg ctttggcaag accagggaga cagatgacaa gacatccccc     1380

ttcctccggg aggtgcaggt caatctcatc gacttcaaga aatgcaatga ctacttggtc     1440

tatgacagtt accttacccc aaggatgatg tgtgctgggg accttcgtgg gggcagagac     1500

tcctgccagg gagacagcgg ggggcctctt gtctgtgagc agaacaaccg ctggtacctg     1560

gcaggtgtca ccagctgggg cacaggctgt ggccagagaa acaaacctgg tgtgtacacc     1620

aaagtgacag aagttcttcc ctggatttac agcaagatgg aggtaagatc cctgcagcag     1680

gacactgcac ccagcaggct gggaacttcc tcaggtgggg accctggagg agcacccagg     1740

gtgtag                                                                1746


<210>  164
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Glu Arg Asp Ser His Gly Asn Ala Ser Pro Ala Arg Thr Pro Ser 
1               5                   10                  15      


Ala Gly Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr Pro Pro Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly 
        35                  40                  45              


Thr Pro Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr 
    50                  55                  60                  


Pro Pro Gly Arg Ala Ser Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser 
65                  70                  75                  80  


Pro Ala Arg Ala Ser Pro Ala Leu Ala Ser Leu Ser Arg Ser Ser Ser 
                85                  90                  95      


Gly Arg Ser Ser Ser Ala Arg Ser Ala Ser Val Thr Thr Ser Pro Thr 
            100                 105                 110         


Arg Val Tyr Leu Val Arg Ala Thr Pro Val Gly Ala Val Pro Ile Arg 
        115                 120                 125             


Ser Ser Pro Ala Arg Ser Ala Pro Ala Thr Arg Ala Thr Arg Glu Ser 
    130                 135                 140                 


Pro Gly Thr Ser Leu Pro Lys Phe Thr Trp Arg Glu Gly Gln Lys Gln 
145                 150                 155                 160 


Leu Pro Leu Ile Gly Cys Val Leu Leu Leu Ile Ala Leu Val Val Ser 
                165                 170                 175     


Leu Ile Ile Leu Phe Gln Phe Trp Gln Gly His Thr Gly Ile Arg Tyr 
            180                 185                 190         


Lys Glu Gln Arg Glu Ser Cys Pro Lys His Ala Val Arg Cys Asp Gly 
        195                 200                 205             


Val Val Asp Cys Lys Leu Lys Ser Asp Glu Leu Gly Cys Val Arg Phe 
    210                 215                 220                 


Asp Trp Asp Lys Ser Leu Leu Lys Ile Tyr Ser Gly Ser Ser His Gln 
225                 230                 235                 240 


Trp Leu Pro Ile Cys Ser Ser Asn Trp Asn Asp Ser Tyr Ser Glu Lys 
                245                 250                 255     


Thr Cys Gln Gln Leu Gly Phe Glu Ser Ala His Arg Thr Thr Glu Val 
            260                 265                 270         


Ala His Arg Asp Phe Ala Asn Ser Phe Ser Ile Leu Arg Tyr Asn Ser 
        275                 280                 285             


Thr Ile Gln Glu Ser Leu His Arg Ser Glu Cys Pro Ser Gln Arg Tyr 
    290                 295                 300                 


Ile Ser Leu Gln Cys Ser His Cys Gly Leu Arg Ala Met Thr Gly Arg 
305                 310                 315                 320 


Ile Val Gly Gly Ala Leu Ala Ser Asp Ser Lys Trp Pro Trp Gln Val 
                325                 330                 335     


Ser Leu His Phe Gly Thr Thr His Ile Cys Gly Gly Thr Leu Ile Asp 
            340                 345                 350         


Ala Gln Trp Val Leu Thr Ala Ala His Cys Phe Phe Val Thr Arg Glu 
        355                 360                 365             


Lys Val Leu Glu Gly Trp Lys Val Tyr Ala Gly Thr Ser Asn Leu His 
    370                 375                 380                 


Gln Leu Pro Glu Ala Ala Ser Ile Ala Glu Ile Ile Ile Asn Ser Asn 
385                 390                 395                 400 


Tyr Thr Asp Glu Glu Asp Asp Tyr Asp Ile Ala Leu Met Arg Leu Ser 
                405                 410                 415     


Lys Pro Leu Thr Leu Ser Ala His Ile His Pro Ala Cys Leu Pro Met 
            420                 425                 430         


His Gly Gln Thr Phe Ser Leu Asn Glu Thr Cys Trp Ile Thr Gly Phe 
        435                 440                 445             


Gly Lys Thr Arg Glu Thr Asp Asp Lys Thr Ser Pro Phe Leu Arg Glu 
    450                 455                 460                 


Val Gln Val Asn Leu Ile Asp Phe Lys Lys Cys Asn Asp Tyr Leu Val 
465                 470                 475                 480 


Tyr Asp Ser Tyr Leu Thr Pro Arg Met Met Cys Ala Gly Asp Leu Arg 
                485                 490                 495     


Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
            500                 505                 510         


Glu Gln Asn Asn Arg Trp Tyr Leu Ala Gly Val Thr Ser Trp Gly Thr 
        515                 520                 525             


Gly Cys Gly Gln Arg Asn Lys Pro Gly Val Tyr Thr Lys Val Thr Glu 
    530                 535                 540                 


Val Leu Pro Trp Ile Tyr Ser Lys Met Glu Val Arg Ser Leu Gln Gln 
545                 550                 555                 560 


Asp Thr Ala Pro Ser Arg Leu Gly Thr Ser Ser Gly Gly Asp Pro Gly 
                565                 570                 575     


Gly Ala Pro Arg Val 
            580     


<210>  165
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  165
atggagaacc tgaagtctgg agtgtatcct ctcaaggaag caagtggatg ccctggggct       60

gacaggaatc ttctggtgta ctctttttat gaaaaggggc cattgacatt tagggatgtg      120

gccatagaat tttctctgga ggagtggcaa tgcctggaca ctgctcagca ggatttgtat      180

agaaaagtga tgttagagaa ctacagaaac ctggtcttct tggcaggtat tgctgtttct      240

aagccagacc tgatcacctg tctagagcaa ggaaaagagc cctggaatat gaagagacat      300

gcgatggtag atcaaccccc agttacatat tctcattttg cccaagacct ttggccagag      360

cagggcataa aagattcttt ccaagaagtc atattgagaa gatatggaaa atgtggacat      420

gaagatttac agttaagaac aggctgtaaa agtgtggatg agtgtaatct gcacaaagaa      480

tgttatgatg aactaaacca gtgtttgaca actacccaga gtgaaatatt tcaatatgat      540

aaatatgtga atgtctttta taaattttca aatccaaata tacaaaagat aagacatact      600

ggaaagaagc ctttcaaatg taaaaaatgt gacaaatcgt tttgcatgct tttacaccta      660

actcaacata aaagaattca tattagggaa aattcttacc aatgtgaaga atgtggtaaa      720

gtctttaact ggttctcaac ccttactaga cacagaagaa ttcatactgg agagaaaccc      780

tacaaatgtg aacaatgtgg caaagctttt aagcagtcct caacccttac tacacataag      840

ataattcata ctggagagaa accctacaga tgtgaagaat gtggcaaaac ctttaaccgg      900

tcctcacacc ttactacaca taaaagaatt catactggag agaaacccta cagatgtgaa      960

gaatgtggca gagcttttaa ccggtcctca caccttacta cacataagat tattcatact     1020

ggagagaaac cctacaaatg tgaagaatgt ggcaaagctt ttaaccaatc ctcaaccctt     1080

actacacata agataattca tgctggagag aaaccttaca aatgtgaaga atgtggcaaa     1140

gctttttacc gattctcata ccttactaaa cataagataa ttcatactgg agagaaattc     1200

tacaaatgtg aagaatgtgg caaaggcttt aattggtcct cgacccttac taaacataaa     1260

agaattcata ctggagagaa accctacaaa tgtgaacaat gtggcaaagc ttttaatgag     1320

tcctcaaacc ttactgcaca taagataatt catactggag agaaacccta caaatgtgaa     1380

gaatgtggca aagcctttaa ccggtcccca aaacttactg cacataaggt aattcattct     1440

ggagagaaac cctacaaatg tgaagaatgt ggcaaagctt ttaaccaatt ctcaaacctt     1500

actaaacata agataactca tattggagat acatcttaca aatacctaga atgtgataaa     1560

gcctttagcc agtcttcaac tcttactaaa cataaggtaa ttcatactgg agagaaaccc     1620

tacaactgtg aagaatacgg caaagctttc aaccagtcct caaaccttat tgaacaaagt     1680

aattcatact ggagagaaac cctacaaatg tga                                  1713


<210>  166
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Glu Asn Leu Lys Ser Gly Val Tyr Pro Leu Lys Glu Ala Ser Gly 
1               5                   10                  15      


Cys Pro Gly Ala Asp Arg Asn Leu Leu Val Tyr Ser Phe Tyr Glu Lys 
            20                  25                  30          


Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu 
        35                  40                  45              


Trp Gln Cys Leu Asp Thr Ala Gln Gln Asp Leu Tyr Arg Lys Val Met 
    50                  55                  60                  


Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Gly Ile Ala Val Ser 
65                  70                  75                  80  


Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Glu Pro Trp Asn 
                85                  90                  95      


Met Lys Arg His Ala Met Val Asp Gln Pro Pro Val Thr Tyr Ser His 
            100                 105                 110         


Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Ile Lys Asp Ser Phe Gln 
        115                 120                 125             


Glu Val Ile Leu Arg Arg Tyr Gly Lys Cys Gly His Glu Asp Leu Gln 
    130                 135                 140                 


Leu Arg Thr Gly Cys Lys Ser Val Asp Glu Cys Asn Leu His Lys Glu 
145                 150                 155                 160 


Cys Tyr Asp Glu Leu Asn Gln Cys Leu Thr Thr Thr Gln Ser Glu Ile 
                165                 170                 175     


Phe Gln Tyr Asp Lys Tyr Val Asn Val Phe Tyr Lys Phe Ser Asn Pro 
            180                 185                 190         


Asn Ile Gln Lys Ile Arg His Thr Gly Lys Lys Pro Phe Lys Cys Lys 
        195                 200                 205             


Lys Cys Asp Lys Ser Phe Cys Met Leu Leu His Leu Thr Gln His Lys 
    210                 215                 220                 


Arg Ile His Ile Arg Glu Asn Ser Tyr Gln Cys Glu Glu Cys Gly Lys 
225                 230                 235                 240 


Val Phe Asn Trp Phe Ser Thr Leu Thr Arg His Arg Arg Ile His Thr 
                245                 250                 255     


Gly Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly Lys Ala Phe Lys Gln 
            260                 265                 270         


Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro 
        275                 280                 285             


Tyr Arg Cys Glu Glu Cys Gly Lys Thr Phe Asn Arg Ser Ser His Leu 
    290                 295                 300                 


Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu 
305                 310                 315                 320 


Glu Cys Gly Arg Ala Phe Asn Arg Ser Ser His Leu Thr Thr His Lys 
                325                 330                 335     


Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
            340                 345                 350         


Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His Ala 
        355                 360                 365             


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Tyr Arg 
    370                 375                 380                 


Phe Ser Tyr Leu Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Phe 
385                 390                 395                 400 


Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn Trp Ser Ser Thr Leu 
                405                 410                 415     


Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
            420                 425                 430         


Gln Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn Leu Thr Ala His Lys 
        435                 440                 445             


Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
    450                 455                 460                 


Ala Phe Asn Arg Ser Pro Lys Leu Thr Ala His Lys Val Ile His Ser 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln 
                485                 490                 495     


Phe Ser Asn Leu Thr Lys His Lys Ile Thr His Ile Gly Asp Thr Ser 
            500                 505                 510         


Tyr Lys Tyr Leu Glu Cys Asp Lys Ala Phe Ser Gln Ser Ser Thr Leu 
        515                 520                 525             


Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Asn Cys Glu 
    530                 535                 540                 


Glu Tyr Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Ile Glu Gln Ser 
545                 550                 555                 560 


Asn Ser Tyr Trp Arg Glu Thr Leu Gln Met 
                565                 570 


<210>  167
<211>  1599
<212>  DNA
<213>  Homo sapiens

<400>  167
atggctccca gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg       60

ttcccaggac ctggcaatgc ccagacatct gtgtccccct caaaagtcat cctgccccgg      120

ggaggctccg tgctggtgac atgcagcacc tcctgtgacc agcccaagtt gttgggcata      180

gagaccccgt tgcctaaaaa ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa      240

ctgagcaatg tgcaagaaga tagccaacca atgtgctatt caaactgccc tgatgggcag      300

tcaacagcta aaaccttcct caccgtgtac tggactccag aacgggtgga actggcaccc      360

ctcccctctt ggcagccagt gggcaagaac cttaccctac gctgccaggt ggagggtggg      420

gcaccccggg ccaacctcac cgtggtgctg ctccgtgggg agaaggagct gaaacgggag      480

ccagctgtgg gggagcccgc tgaggtcacg accacggtgc tggtgaggag agatcaccat      540

ggagccaatt tctcgtgccg cactgaactg gacctgcggc cccaagggct ggagctgttt      600

gagaacacct cggcccccta ccagctccag acctttgtcc tgccagcgac tcccccacaa      660

cttgtcagcc cccgggtcct agaggtggac acgcagggga ccgtggtctg ttccctggac      720

gggctgttcc cagtctcgga ggcccaggtc cacctggcac tgggggacca gaggttgaac      780

cccacagtca cctatggcaa cgactccttc tcggccaagg cctcagtcag tgtgaccgca      840

gaggacgagg gcacccagcg gctgacgtgt gcagtaatac tggggaacca gagccaggag      900

acactgcaga cagtgaccat ctacagcttt ccggcgccca acgtgattct gacgaagcca      960

gaggtctcag aagggaccga ggtgacagtg aagtgtgagg cccaccctag agccaaggtg     1020

acgctgaatg gggttccagc ccagccactg ggcccgaggg cccagctcct gctgaaggcc     1080

accccagagg acaacgggcg cagcttctcc tgctctgcaa ccctggaggt ggccggccag     1140

cttatacaca agaaccagac ccgggagctt cgtgtcctgt atggcccccg actggacgag     1200

agggattgtc cgggaaactg gacgtggcca gaaaattccc agcagactcc aatgtgccag     1260

gcttggggga acccattgcc cgagctcaag tgtctaaagg atggcacttt cccactgccc     1320

atcggggaat cagtgactgt cactcgagat cttgagggca cctacctctg tcgggccagg     1380

agcactcaag gggaggtcac ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag     1440

attgtcatca tcactgtggt agcagccgca gtcataatgg gcactgcagg cctcagcacg     1500

tacctctata accgccagcg gaagatcaag aaatacagac tacaacaggc ccaaaaaggg     1560

acccccatga aaccgaacac acaagccacg cctccctga                            1599


<210>  168
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  169
<211>  8061
<212>  DNA
<213>  Homo sapiens

<400>  169
agaaaggggt agaaatggcg gctccgctcg gctcccgctg aggagggcga agccggcgga       60

gtgtctgtgc tgccggtctg cagcaccgcc cccgcttccc gcacgccgcc tgctcacgcc      120

gacttccctt cctctgcccg gctctctctt gtgctcgtct gcgctccgca cgctccgggc      180

cggctcgtct ctcattgccc ggctcggctc cgctggccct gactgaccgg ccggcgggcc      240

ggccttgctc ggctctcccg ggcgcggcgt ggactccgtc cccctggctg gaccatggtg      300

aacacccgga agagctctct ccgccttctc gggtccaagt ctcctggtcc cgggcctggg      360

cctggggccg gagcagagcc tggggcgacc ggaggcagca gccatttcat ctcctctcgg      420

acccgctcct ccaagacccg cgccgccagc tgccccgccg ccaaagccgg gggaagcggt      480

ggcgccggcg tcactctgga tgaggccagg aaagttgaag ttgatggtag tttaagtgat      540

agccacgtat ctcctccagc caaacgcact ttgaaacaac ctgattctgt ttgcaaagac      600

aaatcaaaat cacgaagtac tggtcagcga gaggaatgga acttatcaac tggacaggcc      660

aggttaactt ctcagcctgg tgctacatta ccaaatggac atagtggctt atcccttcga      720

agccatcccc ttcgagggga aaagaaggga gatggggacc tttcttgtat aaatggtgac      780

atggaagtca gaaaaagttg tcgttccagg aaaaacagat ttgaaagtgt gaaccagagt      840

ttgttatttg atcaactagt aaatagcact gctgaagctg tactacagga aatggacaac      900

attaacatcc gacagaatcg tcgatcagga gaagtagaac gacttcgaat gtggacagat      960

acagaatttg aaaacatgga tatgtattca agagtgaaaa ggcgaagaaa gtcactaaga     1020

agaaatagtt atgggataca aaatcatcat gaagtttcta ctgagggtga agaagaagaa     1080

tctcaagagg aggatggaga tatagaagtt gaagaggcag aaggagaaga aaatgataga     1140

ccatataatt tgagacagag aaaaacagtg gatcgatacc aagcacctcc aatagtacca     1200

gctcatcaaa aaaagaggga aaacacgctg tttgatattc atagatctcc agcaagaaga     1260

agccatatta ggagaaagaa gcatgccatt catagtagtg acacaacttc ttctgatgag     1320

gaacgctttg aaagaaggaa atcaaagagc atggcaagag caagaaatag atgtttgcct     1380

atgaacttca gagcagagga cttagctagc ggtattctcc gagaacgagt gaaagtgggt     1440

gcaagcttgg ctgatgttga tccaatgaac attgataaat cagtacggtt tgatagcata     1500

ggtggattga gccatcatat tcatgcgcta aaggaaatgg tagtattccc acttttatat     1560

ccagaaattt ttgaaaagtt taaaattcag cctccaaggg gctgtttgtt ttatggccct     1620

cctggcacag gtaaaacctt ggttgccaga gcattagcta atgaatgcag ccaaggagac     1680

aaaaaagtgg ctttttttat gcgaaaagga gcagattgtt tgagcaagtg ggttggtgaa     1740

tctgaaaggc aacttaggct tctttttgat caggcatatt tgatgagacc ttctataata     1800

ttttttgatg aaatagatgg attagctcca gttcgctcta gcagacaaga tcagatccac     1860

agctctatag tatcaaccct ccttgctctt atggatggat tagataatag gggtgaaatt     1920

gttgttattg gtgctacaaa cagacttgac tctatagatc ctgcactcag gagacctggt     1980

cgttttgaca gagaattcct cttcaacctg cctgatcaaa aggcaagaaa acacatctta     2040

cagatccata ccagggactg gaatccaaaa ttgtcagatg catttttagg tgaattggct     2100

gaaaaatgtg ttggctactg tggagccgat atcaaggccc tgtgcactga agccgccctg     2160

attgcactgc ggaggcgtta tccccagatc tatgctagca gtcataaact gcagctggat     2220

gtttcctcaa tagtgcttag tgcccaagat ttttaccatg caatgcagaa tatcgtgcct     2280

gcttcccaac gtgctgtgat gtcttcaggg catgcactat cccccatcat aagaccactg     2340

ctggaaagaa gcttcaacaa catcctagca gtcttgcaaa aagtgtttcc tcatgctgaa     2400

attagccaga gtgacaaaaa agaagatata gaaactttaa ttttagagga tagtgaagat     2460

gaaaatgctt tatcaatttt tgagaccaat tgtcactcag gatcaccaaa gaaacagtca     2520

tcatctgctg ctatacataa accctacctt cattttacaa tgtcaccata tcatcagcca     2580

acctcttaca ggccacgctt attgctctct ggagaacggg gctcaggtca aacttctcac     2640

cttgctccag cacttttgca cactctagaa agattctctg tgcatagact agatctccca     2700

gcactttatt cagttagtgc caaaacacct gaggaatcat gtgcacagat ttttcgtgaa     2760

gctcgaagaa cagtacctag tattgtttac atgcctcaca ttggggattg gtgggaagct     2820

gtcagtgaaa ctgtgagagc aacttttctg acattgctac aagatatacc atcattttca     2880

cctatatttt tattgtctac ctctgaaacc atgtacagtg aactgcctga agaggttaaa     2940

tgtatcttta gaatacagta tgaagaggtc ttgtatattc aaaggcctat tgaagaagac     3000

agaagaaaat tttttcaaga attgattctc aatcaggcat caatggctcc accacgaagg     3060

aaacatgctg ctctttgtgc tatggaagtg cttcctcttg cactaccttc tccacctcgt     3120

caattatcag aatcagaaaa aagtcgaatg gaggaccagg aggaaaatac tttaagagag     3180

ttgcggttgt ttctcaggga tgtaaccaag aggctggcca cagataaacg ctttaacatc     3240

ttcagcaaac cggtggatat tgaagaggtt tcagattatc ttgaagtaat caaggaacca     3300

atggacttat caacagtaat aactaaaatt gataaacata attacctgac tgcaaaggat     3360

ttcctgaaag atattgacct catctgtagc aatgctttag agtataatcc agataaggac     3420

ccaggagata aaataattag gcacagggct tgtaccctga aggacactgc acatgctatc     3480

attgcagctg aattagatcc agaatttaat aaactttgtg aggaaattaa ggaagcaaga     3540

ataaaaagag gcttatcagt aacatcagaa caaataaatc ctcatagtac tggagctcgg     3600

aagacagaaa ctagagtcga agaggcattt cggcacaaac aaagaaatcc aatggatgtg     3660

tggcacaact ctgcaaataa atgtgcattt cgggttcgga gaaaatcaag gcggagatca     3720

cagtggggta aaggaattat taagaaaagg aaagttaata atttaaaaaa agatgaagaa     3780

gacaccaaat ttgcagacta tgagaaccat acggaggaca ggaaattatt agagaatgga     3840

gagtttgagg taagcactga ctgccatgag gaaaatggag aagagactgg agacttatct     3900

atgaccaatg atgaatcatc ctgtgacatc atggacttgg accaggggca gaggcttaac     3960

aatggagcag gcacaaaaga gaactttgca tctactgagg aggaaagttc aaatgaatct     4020

ctactggtca acagcagcag ttccttaaac ccggagcaga cctccaggaa agagactttc     4080

cttaaaggaa attgtctaaa tggtgaggct tccactgaca gttttgaagg aataccagtt     4140

ctggaatgtc agaatggcaa gcttgaagta gtttctttct gtgatagtgg agataaatgt     4200

agttctgaac aaaagattct tctggaggac cagtcaaaag aaaaaccaga aacttcgact     4260

gaaaatcatg gagatgatct tgagaaacta gaggcactgg aatgtagcaa taatgagaag     4320

ttagaacctg gctctgatgt ggaggttaaa gatgcagaac tggataaaga aggtgcttct     4380

aaagtaaaga aataccgtaa attaatttta gagcaggcaa aaacgacaag cctggaactg     4440

gttccagaag agccatctga gcctgtgcct cctcttatag ttgatcgtga gagattgaag     4500

aaattgcttg atttgttggt ggataaaagc aacaatctgg cagttgatca gcttgagaga     4560

ttatattctc ttcttagtca gtgtatctac cgtcatcgta aagattatga caaatcacaa     4620

cttgtagagg agatggaaag aacagttcat atgtttgaga cattcctatg aacttttcaa     4680

gatgagtggt ttatcctctc caatctgctc ctcacagagc agtcttctga gccattcaat     4740

ttcaaattgc accaattatg tgcagagcct tggtgtaaag tgctctctca ctcattcttt     4800

ctctctgttg aatttggtgc tattgtctca ggtacctgaa accaaccagc ctacaagaac     4860

caaacagaac ttcagaaaca tgttgtattt tccacaaata aaaaatacaa ccccacagct     4920

tggagatttt ggtgctacag aaactgctct cgcttctgct cctctttttg tgcactctct     4980

tttggagact cctctcttag ggagcagacc agcaaacagg aggaaactgg atgggggcag     5040

ttctaactgt gttgaattgt ttaaacagtg ggcaacttgt tatttttttt tcctccattt     5100

taccccttta atcatatttt tcccccatct gggtaatgga ctgaaacctg ttttagagtt     5160

ggctatggtc tgttctggtg ggaagctgaa gaaactggat gaaattaggt caggctcttt     5220

agaactgcct ttaacgtgcc tttttattca tttgaggaag ataaggctaa aaggatgggc     5280

tgtttgaagc aaataaatta gaaatatttc tttggtcaca accttgaaaa taagttttga     5340

tactctatgt cattaagaga caaccagtgt ttgggtatga aatgcctgtc ttattctcaa     5400

agctcaatca agacacccag taagccacat aatatactaa aatggtaagt tttcttgtaa     5460

ggtctgtttt ggtttaagaa acatgaataa caacaaagaa taatacacag tccacacaca     5520

aaaaaacaaa aaacaaaact gcacacgttt tggtattgcc aacaatgatg actagaaaat     5580

aaatagatag tggccatttt ttcttctgtc agtggcaatt taatagttat tcatgtttga     5640

gttcccagag aaaaatggtt ttcatatgta gtaaattgtt gttttgtttt aaagccagga     5700

cttgccaaat ggacagaaaa gagaggaatt catcagaagc tccataaaat tcattttctg     5760

tatgcttaat tgcaaacgag ctctggtatg gtccttgaat aacagtatta atgtttaaat     5820

cccatctcct aagcttacct tcacaactct tctttttgat tggaaaccat tttgaatctt     5880

gttgagtgat ttctgtgaat tgtatgtatc tgaaattaat tatgggttac tagttttaca     5940

aaaactttct acaaatttgg agacacagtc taggcagttg caatgaggca aaggatgcag     6000

tgactttttt tatcagatga tttttaaaca aaaagaaaat tttgccagca agttggcttg     6060

gtatcttcat tcattgtagc cgttagctgc aggtgtgtct ttccaatata tgcaacacat     6120

gtagtttggg ttttaattag ggcgaatggt cttggactac tgcagagatt ctgagctacc     6180

tcagcttttt gtattttagt taccaacagt gtttacagag tcttgtaatc actttgccac     6240

cgtttacatc ctgaagctaa ggtacttgtc tccttgtctt tggctctttg tagtgtgcag     6300

aaagcatact ttggccatag cctactgcag taatccaaag tgcttctttg catttacatt     6360

tacatctaac gccttctaat tctagcttaa ttttttttta aatgccacgt gttttctttg     6420

tacctagtct gtgaagtttc tgtaatatcc agttagtcat acaagtcaag atgctaccca     6480

tgtagacaca ctgtattttt aaggtgggca agtgcgatta acgatgaacc attttaaagg     6540

ggaggttatt tgaaacctct aatttgatta ttgggaggat tttcatgctt tctttagtat     6600

ttattaccat cataccgatt caaactattt tattgtctaa tacattagca ttttgtattt     6660

tgatggaaat tgttacagaa tttaaagatt tgatgaaata agatgtagca gattttttgt     6720

agcaagtttc tggtaaaagg gttttttgca agtctcaggt tcttgctgca ctattttttt     6780

ttaaatattt attccagtta ttctaattca gaagcattct tttcaagtaa cagcagcact     6840

tgtgaaagga aaaaaaaatg cacatgtttc ttagtaggtt actaaatttg tacaattaat     6900

taagatttta gccatcagtg agtttgaaaa gggaaatgta tttattttca gcattaaaat     6960

gcttccaaaa gatcaagttg cttttgtttg tttgtttttt taaccgtaat gtagatggag     7020

aaattggagg caacctcagt ataggaactg ccactttgaa cagtttaggt cttaaagaga     7080

aagtcaatct aatgccaagg ggagaacaat gagctgaaat tgtaccaact cctctggccc     7140

tccttccctc aattaaaaaa acacacttac cagttttgct tattttacag atatctggtg     7200

gttctatagt ttaaagcagc ttgtgaaatt aaaaaagtgg actcaatttt gtttaccttt     7260

ctgtaagttt ttcatttttg ctgtatagca ttggcaaaaa tatgtacaaa ttgacctctg     7320

ttcttatttc ctattgtgag cattataaag ataagctcct atgtaaaacc ttgctctcag     7380

atgagtaaaa tatgtatcac agcatagctc agcaataatt catgctcagc tgtggggacc     7440

ctgggggctt tttgaagatg atggaaccgc actagggttg aaactgatgg ctgtggagtt     7500

aattgtgttt tcgagcttga atctcacctg tgattttttt tttttaatgt tgtttcatga     7560

cttgattttt ctcataagcc aatgtatttg taggtttact ggattttatt tttagggagt     7620

gggtaatttc ttcccttttt tgattaagtt ggttcagcta tggtgctatt cagtaggtat     7680

cttcagtgtc aggtcccgta gctgaatgcc attgttatta taattattat ttgtaatcac     7740

attgtaagct tgaatttggg cttgtacctg catcttttgt attctgtaca tctggttact     7800

tagactttgg gagtccaatt tggtttcagt catgtatgtc tactttgtag tttaagtaga     7860

cttcatcaac tatggtctat tttgggtttg tagttttaat ttagaattgt gttaaattga     7920

tgttttgcat ttgacttcat ttgacattag ttgaagtaaa ttatttaatt tttgaattct     7980

ggaatttgaa catttactgt aatttgtaat ataactgctg tgaaatactt gaataaagat     8040

gacaagaaaa acaaaaaaaa a                                               8061


<210>  170
<211>  1458
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Val Asn Thr Arg Lys Ser Ser Leu Arg Leu Leu Gly Ser Lys Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Gly Pro Gly Ala Gly Ala Glu Pro Gly Ala Thr 
            20                  25                  30          


Gly Gly Ser Ser His Phe Ile Ser Ser Arg Thr Arg Ser Ser Lys Thr 
        35                  40                  45              


Arg Ala Ala Ser Cys Pro Ala Ala Lys Ala Gly Gly Ser Gly Gly Ala 
    50                  55                  60                  


Gly Val Thr Leu Asp Glu Ala Arg Lys Val Glu Val Asp Gly Ser Leu 
65                  70                  75                  80  


Ser Asp Ser His Val Ser Pro Pro Ala Lys Arg Thr Leu Lys Gln Pro 
                85                  90                  95      


Asp Ser Val Cys Lys Asp Lys Ser Lys Ser Arg Ser Thr Gly Gln Arg 
            100                 105                 110         


Glu Glu Trp Asn Leu Ser Thr Gly Gln Ala Arg Leu Thr Ser Gln Pro 
        115                 120                 125             


Gly Ala Thr Leu Pro Asn Gly His Ser Gly Leu Ser Leu Arg Ser His 
    130                 135                 140                 


Pro Leu Arg Gly Glu Lys Lys Gly Asp Gly Asp Leu Ser Cys Ile Asn 
145                 150                 155                 160 


Gly Asp Met Glu Val Arg Lys Ser Cys Arg Ser Arg Lys Asn Arg Phe 
                165                 170                 175     


Glu Ser Val Asn Gln Ser Leu Leu Phe Asp Gln Leu Val Asn Ser Thr 
            180                 185                 190         


Ala Glu Ala Val Leu Gln Glu Met Asp Asn Ile Asn Ile Arg Gln Asn 
        195                 200                 205             


Arg Arg Ser Gly Glu Val Glu Arg Leu Arg Met Trp Thr Asp Thr Glu 
    210                 215                 220                 


Phe Glu Asn Met Asp Met Tyr Ser Arg Val Lys Arg Arg Arg Lys Ser 
225                 230                 235                 240 


Leu Arg Arg Asn Ser Tyr Gly Ile Gln Asn His His Glu Val Ser Thr 
                245                 250                 255     


Glu Gly Glu Glu Glu Glu Ser Gln Glu Glu Asp Gly Asp Ile Glu Val 
            260                 265                 270         


Glu Glu Ala Glu Gly Glu Glu Asn Asp Arg Pro Tyr Asn Leu Arg Gln 
        275                 280                 285             


Arg Lys Thr Val Asp Arg Tyr Gln Ala Pro Pro Ile Val Pro Ala His 
    290                 295                 300                 


Gln Lys Lys Arg Glu Asn Thr Leu Phe Asp Ile His Arg Ser Pro Ala 
305                 310                 315                 320 


Arg Arg Ser His Ile Arg Arg Lys Lys His Ala Ile His Ser Ser Asp 
                325                 330                 335     


Thr Thr Ser Ser Asp Glu Glu Arg Phe Glu Arg Arg Lys Ser Lys Ser 
            340                 345                 350         


Met Ala Arg Ala Arg Asn Arg Cys Leu Pro Met Asn Phe Arg Ala Glu 
        355                 360                 365             


Asp Leu Ala Ser Gly Ile Leu Arg Glu Arg Val Lys Val Gly Ala Ser 
    370                 375                 380                 


Leu Ala Asp Val Asp Pro Met Asn Ile Asp Lys Ser Val Arg Phe Asp 
385                 390                 395                 400 


Ser Ile Gly Gly Leu Ser His His Ile His Ala Leu Lys Glu Met Val 
                405                 410                 415     


Val Phe Pro Leu Leu Tyr Pro Glu Ile Phe Glu Lys Phe Lys Ile Gln 
            420                 425                 430         


Pro Pro Arg Gly Cys Leu Phe Tyr Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Val Ala Arg Ala Leu Ala Asn Glu Cys Ser Gln Gly Asp Lys Lys 
    450                 455                 460                 


Val Ala Phe Phe Met Arg Lys Gly Ala Asp Cys Leu Ser Lys Trp Val 
465                 470                 475                 480 


Gly Glu Ser Glu Arg Gln Leu Arg Leu Leu Phe Asp Gln Ala Tyr Leu 
                485                 490                 495     


Met Arg Pro Ser Ile Ile Phe Phe Asp Glu Ile Asp Gly Leu Ala Pro 
            500                 505                 510         


Val Arg Ser Ser Arg Gln Asp Gln Ile His Ser Ser Ile Val Ser Thr 
        515                 520                 525             


Leu Leu Ala Leu Met Asp Gly Leu Asp Asn Arg Gly Glu Ile Val Val 
    530                 535                 540                 


Ile Gly Ala Thr Asn Arg Leu Asp Ser Ile Asp Pro Ala Leu Arg Arg 
545                 550                 555                 560 


Pro Gly Arg Phe Asp Arg Glu Phe Leu Phe Asn Leu Pro Asp Gln Lys 
                565                 570                 575     


Ala Arg Lys His Ile Leu Gln Ile His Thr Arg Asp Trp Asn Pro Lys 
            580                 585                 590         


Leu Ser Asp Ala Phe Leu Gly Glu Leu Ala Glu Lys Cys Val Gly Tyr 
        595                 600                 605             


Cys Gly Ala Asp Ile Lys Ala Leu Cys Thr Glu Ala Ala Leu Ile Ala 
    610                 615                 620                 


Leu Arg Arg Arg Tyr Pro Gln Ile Tyr Ala Ser Ser His Lys Leu Gln 
625                 630                 635                 640 


Leu Asp Val Ser Ser Ile Val Leu Ser Ala Gln Asp Phe Tyr His Ala 
                645                 650                 655     


Met Gln Asn Ile Val Pro Ala Ser Gln Arg Ala Val Met Ser Ser Gly 
            660                 665                 670         


His Ala Leu Ser Pro Ile Ile Arg Pro Leu Leu Glu Arg Ser Phe Asn 
        675                 680                 685             


Asn Ile Leu Ala Val Leu Gln Lys Val Phe Pro His Ala Glu Ile Ser 
    690                 695                 700                 


Gln Ser Asp Lys Lys Glu Asp Ile Glu Thr Leu Ile Leu Glu Asp Ser 
705                 710                 715                 720 


Glu Asp Glu Asn Ala Leu Ser Ile Phe Glu Thr Asn Cys His Ser Gly 
                725                 730                 735     


Ser Pro Lys Lys Gln Ser Ser Ser Ala Ala Ile His Lys Pro Tyr Leu 
            740                 745                 750         


His Phe Thr Met Ser Pro Tyr His Gln Pro Thr Ser Tyr Arg Pro Arg 
        755                 760                 765             


Leu Leu Leu Ser Gly Glu Arg Gly Ser Gly Gln Thr Ser His Leu Ala 
    770                 775                 780                 


Pro Ala Leu Leu His Thr Leu Glu Arg Phe Ser Val His Arg Leu Asp 
785                 790                 795                 800 


Leu Pro Ala Leu Tyr Ser Val Ser Ala Lys Thr Pro Glu Glu Ser Cys 
                805                 810                 815     


Ala Gln Ile Phe Arg Glu Ala Arg Arg Thr Val Pro Ser Ile Val Tyr 
            820                 825                 830         


Met Pro His Ile Gly Asp Trp Trp Glu Ala Val Ser Glu Thr Val Arg 
        835                 840                 845             


Ala Thr Phe Leu Thr Leu Leu Gln Asp Ile Pro Ser Phe Ser Pro Ile 
    850                 855                 860                 


Phe Leu Leu Ser Thr Ser Glu Thr Met Tyr Ser Glu Leu Pro Glu Glu 
865                 870                 875                 880 


Val Lys Cys Ile Phe Arg Ile Gln Tyr Glu Glu Val Leu Tyr Ile Gln 
                885                 890                 895     


Arg Pro Ile Glu Glu Asp Arg Arg Lys Phe Phe Gln Glu Leu Ile Leu 
            900                 905                 910         


Asn Gln Ala Ser Met Ala Pro Pro Arg Arg Lys His Ala Ala Leu Cys 
        915                 920                 925             


Ala Met Glu Val Leu Pro Leu Ala Leu Pro Ser Pro Pro Arg Gln Leu 
    930                 935                 940                 


Ser Glu Ser Glu Lys Ser Arg Met Glu Asp Gln Glu Glu Asn Thr Leu 
945                 950                 955                 960 


Arg Glu Leu Arg Leu Phe Leu Arg Asp Val Thr Lys Arg Leu Ala Thr 
                965                 970                 975     


Asp Lys Arg Phe Asn Ile Phe Ser Lys Pro Val Asp Ile Glu Glu Val 
            980                 985                 990         


Ser Asp Tyr Leu Glu Val Ile Lys  Glu Pro Met Asp Leu  Ser Thr Val 
        995                 1000                 1005             


Ile Thr  Lys Ile Asp Lys His  Asn Tyr Leu Thr Ala  Lys Asp Phe 
    1010                 1015                 1020             


Leu Lys  Asp Ile Asp Leu Ile  Cys Ser Asn Ala Leu  Glu Tyr Asn 
    1025                 1030                 1035             


Pro Asp  Lys Asp Pro Gly Asp  Lys Ile Ile Arg His  Arg Ala Cys 
    1040                 1045                 1050             


Thr Leu  Lys Asp Thr Ala His  Ala Ile Ile Ala Ala  Glu Leu Asp 
    1055                 1060                 1065             


Pro Glu  Phe Asn Lys Leu Cys  Glu Glu Ile Lys Glu  Ala Arg Ile 
    1070                 1075                 1080             


Lys Arg  Gly Leu Ser Val Thr  Ser Glu Gln Ile Asn  Pro His Ser 
    1085                 1090                 1095             


Thr Gly  Ala Arg Lys Thr Glu  Thr Arg Val Glu Glu  Ala Phe Arg 
    1100                 1105                 1110             


His Lys  Gln Arg Asn Pro Met  Asp Val Trp His Asn  Ser Ala Asn 
    1115                 1120                 1125             


Lys Cys  Ala Phe Arg Val Arg  Arg Lys Ser Arg Arg  Arg Ser Gln 
    1130                 1135                 1140             


Trp Gly  Lys Gly Ile Ile Lys  Lys Arg Lys Val Asn  Asn Leu Lys 
    1145                 1150                 1155             


Lys Asp  Glu Glu Asp Thr Lys  Phe Ala Asp Tyr Glu  Asn His Thr 
    1160                 1165                 1170             


Glu Asp  Arg Lys Leu Leu Glu  Asn Gly Glu Phe Glu  Val Ser Thr 
    1175                 1180                 1185             


Asp Cys  His Glu Glu Asn Gly  Glu Glu Thr Gly Asp  Leu Ser Met 
    1190                 1195                 1200             


Thr Asn  Asp Glu Ser Ser Cys  Asp Ile Met Asp Leu  Asp Gln Gly 
    1205                 1210                 1215             


Gln Arg  Leu Asn Asn Gly Ala  Gly Thr Lys Glu Asn  Phe Ala Ser 
    1220                 1225                 1230             


Thr Glu  Glu Glu Ser Ser Asn  Glu Ser Leu Leu Val  Asn Ser Ser 
    1235                 1240                 1245             


Ser Ser  Leu Asn Pro Glu Gln  Thr Ser Arg Lys Glu  Thr Phe Leu 
    1250                 1255                 1260             


Lys Gly  Asn Cys Leu Asn Gly  Glu Ala Ser Thr Asp  Ser Phe Glu 
    1265                 1270                 1275             


Gly Ile  Pro Val Leu Glu Cys  Gln Asn Gly Lys Leu  Glu Val Val 
    1280                 1285                 1290             


Ser Phe  Cys Asp Ser Gly Asp  Lys Cys Ser Ser Glu  Gln Lys Ile 
    1295                 1300                 1305             


Leu Leu  Glu Asp Gln Ser Lys  Glu Lys Pro Glu Thr  Ser Thr Glu 
    1310                 1315                 1320             


Asn His  Gly Asp Asp Leu Glu  Lys Leu Glu Ala Leu  Glu Cys Ser 
    1325                 1330                 1335             


Asn Asn  Glu Lys Leu Glu Pro  Gly Ser Asp Val Glu  Val Lys Asp 
    1340                 1345                 1350             


Ala Glu  Leu Asp Lys Glu Gly  Ala Ser Lys Val Lys  Lys Tyr Arg 
    1355                 1360                 1365             


Lys Leu  Ile Leu Glu Gln Ala  Lys Thr Thr Ser Leu  Glu Leu Val 
    1370                 1375                 1380             


Pro Glu  Glu Pro Ser Glu Pro  Val Pro Pro Leu Ile  Val Asp Arg 
    1385                 1390                 1395             


Glu Arg  Leu Lys Lys Leu Leu  Asp Leu Leu Val Asp  Lys Ser Asn 
    1400                 1405                 1410             


Asn Leu  Ala Val Asp Gln Leu  Glu Arg Leu Tyr Ser  Leu Leu Ser 
    1415                 1420                 1425             


Gln Cys  Ile Tyr Arg His Arg  Lys Asp Tyr Asp Lys  Ser Gln Leu 
    1430                 1435                 1440             


Val Glu  Glu Met Glu Arg Thr  Val His Met Phe Glu  Thr Phe Leu 
    1445                 1450                 1455             


<210>  171
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  171
atggagctac tgtcgccacc gctccgcgac gtagacctga cggcccccga cggctctctc       60

tgctcctttg ccacaacgga cgacttctat gacgacccgt gtttcgactc cccggacctg      120

cgcttcttcg aagacctgga cccgcgcctg atgcacgtgg gcgcgctcct gaaacccgaa      180

gagcactcgc acttccccgc ggcggtgcac ccggccccgg gcgcacgtga ggacgagcat      240

gtgcgcgcgc ccagcgggca ccaccaggcg ggccgctgcc tactgtgggc ctgcaaggcg      300

tgcaagcgca agaccaccaa cgccgaccgc cgcaaggccg ccaccatgcg cgagcggcgc      360

cgcctgagca aagtaaatga ggcctttgag acactcaagc gctgcacgtc gagcaatcca      420

aaccagcggt tgcccaaggt ggagatcctg cgcaacgcca tccgctatat cgagggcctg      480

caggctctgc tgcgcgacca ggacgccgcg ccccctggcg ccgcagccgc cttctatgcg      540

ccgggcccgc tgcccccggg ccgcggcggc gagcactaca gcggcgactc cgacgcgtcc      600

agcccgcgct ccaactgctc cgacggcatg atggactaca gcggcccccc gagcggcgcc      660

cggcggcgga actgctacga aggcgcctac tacaacgagg cgcccagcga acccaggccc      720

gggaagagtg cggcggtgtc gagcctagac tgcctgtcca gcatcgtgga gcgcatctcc      780

accgagagcc ctgcggcgcc cgccctcctg ctggcggacg tgccttctga gtcgcctccg      840

cgcaggcaag aggctgccgc ccccagcgag ggagagagca gcggcgaccc cacccagtca      900

ccggacgccg ccccgcagtg ccctgcgggt gcgaacccca acccgatata ccaggtgctc      960

tga                                                                    963


<210>  172
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Val Asp Leu Thr Ala Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
    50                  55                  60                  


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
            180                 185                 190         


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
        195                 200                 205             


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
    210                 215                 220                 


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
225                 230                 235                 240 


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
                245                 250                 255     


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
            260                 265                 270         


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
        275                 280                 285             


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
    290                 295                 300                 


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
305                 310                 315                 320 


<210>  173
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  173
caggtcaact taagggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcgcct tctctgggtt ctcactcagc actagtggag tgtgtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggataa tgataaattc      180

tacagcacat ctctgaagac caggctctcc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccgacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgagtaagtg gtggtagccg ctactactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcgagt                                                    378


<210>  174
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  174

Gln Val Asn Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asn Asp Lys Phe Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Ser Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asp Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Val Ser Gly Gly Ser Arg Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  175
<211>  8370
<212>  DNA
<213>  Homo sapiens

<400>  175
atgcccagtg atgccaaaga cagtgttaat ggtgaccttt tgttaaattg gacaagtctt       60

aaaaatattt taagtggtct taatgcttct tttcctcttc acaacaatac tggctcaagc      120

acagtcacta cttcaaaatc catcaaagac ccaagactga tgaggagaga agaaagtatg      180

ggagaacaga gtagtactgc aggcttaaat gaggttttgc aatttgagaa gagttcagat      240

aatgttaatt cagaaataaa atcgacacca tctaattctg cctcctcctc agaagttgtc      300

cctggtgatt gtgctgttct tactaatggt ttggataccc cttgctttaa aacttctgtt      360

aatgattcac aatcttgggc tcacaacatg ggctctgagg actatgactg tatacctccc      420

aataaagtta ccatggcagg gcaatgtaag gaccaaggta atttttcctt cccaatttct      480

gtgtcaaatg tagtgtcaga ggttgagaac caaaaccaca gtgaggagaa ggctcagaga      540

gcccaacagg agtccggtaa tgcttataca aaagagtaca gtagtcacat ttttcaggac      600

tcgcagtctt ctgatttaaa aacaatttat cagactggtt gccaaacgtc tacagttttt      660

ccactcaaaa agaaagtaag cattgatgaa taccttcaaa atactggaaa gatgaaaaac      720

ttcgctgacc tggaagacag ttccaaacat gaagaaaagc aaacttcatg gaaagaaatt      780

gataatgatt tcactaatga aacaaaaatc agtccaatag ataattacat tgttttgcac      840

caagaataca aagagagtga gagtcataat tcttttggga aaagctgtga taaaatatta      900

attactcaag agttagaaat aacaaaatct tctacatcta ccataaagga taaggatgaa      960

ctagatcatc tagcattgga atggcaaatt actccaagtt ttgagagcct gtcacaaaag     1020

catcctcagc actctgtgga gtatgagggt aacattcata caagtttagc cattgctcaa     1080

aagctaatgg aactgaaatt ggggaaaata aatcaaaatt atgctagcat tataactgaa     1140

gctttcccga aaccaaaaga cataccccag gccaaagaaa tgttcattga tacagttatt     1200

tcatcttata acatagaaac agctcatgac agttcaaatt gcagcataac tagagaacat     1260

atatgtgtcc ataggaaaaa tgaaaatgaa ccagtgtcat tagagaacat tcagagagac     1320

tataaagaaa ctgcttatgt tgaagatagg ggtcaggatc acaatctgtt ctgtaattca     1380

cagttaagca atgatatatg gctgaatgtt aatttcaaaa aacaaacaga tagagaaaac     1440

caaaatgagg ctaaagagaa tagtgcttca tgtgtagaaa acaacataga gaacatatat     1500

ggagacaaaa agcaggattc tcatacaaac gaaaatttca gcaatataga tgaaaaggag     1560

gacaaaaatt accacaatat agaaattttg agttctgaag aattttctac taaatttaac     1620

ttgatttgca gagaagataa tgcagtgtca gcagcaactg cattattaga gagtgaagaa     1680

gataccatta gtgccgtgaa acaaaaagat actgaaaata ctggaagaag tgtagagcat     1740

ttggcttcca cgacatttcc caaaactgca agttcttcag tgtgtgtagc ctcaaatgct     1800

gcaatacaga tagctagtgc tactatgcct gcattaagcc taaataatga cgatcaccag     1860

atataccagt ttaaagaaac ttgttcttct gaaagtccag attttggttt gttagtaaaa     1920

catagggttt ctgattgtga aattgatacg gataaaaata aatcacaaga atcatttcat     1980

caatcaataa atgagaactt agttcttcag agcattgaat tggaaagtga aattgaaata     2040

gaattagaag attgtgatga tgcttttata tttcaacaag atacacatag ccatgaaaac     2100

atgctttgtg aagaatttgt gacctcatat aaggctctga agtctcgtat cagttgggaa     2160

ggtctgttag cacttgataa cggggagatg gaagttttgg aaagcaccac aggaagggag     2220

aatagtgatc agcattattc taaggaaagt aactattttt attcctctac acaaaacaat     2280

gaaacagaac ttaccagccc aattttactt ccagatctac aaattaaaat tactaatata     2340

tttaggccag gattcagccc gacagctgac tcccttgcat tgaaagatag tttttgcaca     2400

catgtaactg aagccacaaa accggaaata aataaggaag atggagaaat tctaggattt     2460

gacatttatt cccagccttt tggtgaaaat gcagattatc catgtgaaga taaagttgat     2520

aatataaggc aagaatcagg gccagtgagt aactctgaaa tctccctttc ttttgacttg     2580

agtcgtaata cagatgtgaa tcatacgtct gaaaatcaga acagtgaatc tttgtttact     2640

gaaccttcta atgtcacaac aatagatgat ggaagcagat gtttctttac aaaatcaaaa     2700

actgactata atgataccaa aaataaaaag gaggtagaat caagaattag caaaaggaag     2760

ctacatatat cttccaggga tcagaacata ccacataaag atttaagacg acataaaatt     2820

tatgggagaa agaggaggct aaccagtcaa gactcatctg agtgtttctc ttcattatcc     2880

caaggacgaa ttaaaacatt ttcacagtca gaaaagcaca ttaagagtgt cctaaatatc     2940

ctaagtgatg aagcatcttt atgtaaaagc aaatgtcttt ccagaaaact agacaaagca     3000

gttgttcact taaaaaaagc tcatagaaga gttcacacat ctttgcagct tataactaaa     3060

gtaggagaag aaagaaaggg cccattacca aaatcatatg caataatatg caataatttc     3120

tgggaaagtt gtgaccttca aggttatagt tctgtgtctc aaagaaaata ttattctact     3180

aagcattttt cgtcaaaaag aaaatatgac aaacggagaa agaaaagagc tccaaaagct     3240

gatatttcta aatcattaac ccatgtgtca aagcacaagt cttataaaac aagtggagag     3300

aaaaaatgcc tttctaggaa aagtatggct agcagtgtct caaaaagtca ccccaccacc     3360

agtcacatgg gagaattttg taatcaagaa catcctgaat cacagttgcc tgtatcctcc     3420

acatcccaaa gtacaagtca gtcagtttat tataatagca gtgtaagcaa tccaagttta     3480

tcagaagaac atcagccctt ttctggaaaa actgcatatc tgttttcccc agaccactca     3540

gatgagaaac taatagaaaa agaaaatcaa attgatacag catttttatc tagcactagt     3600

aaatatgaaa agcttgaaaa acattcagca aatcataatg ttaaagatgc aactaaagaa     3660

aacagttgtg acgctaatga agtaataaat gaaagtaatt ctgtatcttt aagttgcata     3720

aaagaaaaca taaattctag tacaggcaac gattgtgatg caacttgcat aggtcacaca     3780

aaggcgaaaa ctgacgtact tatatcagtc ttagattcaa atgtgaagca ctttttaaat     3840

gatctctacc aacaaggtaa ccttatttta tctgattgta aaagaaacct ggaagtaaag     3900

tggacagatc ctattgagag acccaaacaa aacattatta caggaaactt ccttatgggc     3960

ccattaaacc taactttgat agcaagtaaa aagtacagta ttcctcagtt atcagccgct     4020

gcagtgacag atagtgaggg agaatcttca aaatcttact tggataagca gagaattctt     4080

actgtagatt cttttgcagc atccagtact gtaccacact gtgagcagag ctgtagagaa     4140

aaagagcttc taaagacaga acagtgctct tcaggtaatt gcctccatac agatgggaat     4200

gaaacaaatg tcactgagaa ttatgagttg gatgtagcat caggaactga agaagataaa     4260

agttatgggg aaaatatagt ggaattatct tccagtgata gttctctgct tttaaaagat     4320

aatgtaaaag gctcctcttc agaaacatgt attgtgaaga aagacactga ggacagaata     4380

acgtggaaag ttaaacaagc ggaaaaagca aaagattctg tttacaaaag aagcatgact     4440

gaaggatcaa ctgttaatac tgagtacaaa aatcaaaaga atcagatctc agaagaatcc     4500

tgcttaaatg agaaaattat tacaactaac ttgattgatt cccatctgag cactaaaaat     4560

actaccactg agtcagtccc tttgaagaac acagtttcta atccgcttaa caaaagagag     4620

aagaaggggg aaattaaagt tagtaaagac tcgcagtctg acttgacatt acattcagaa     4680

atagcctata tttccaaacc aggaattcta ggagttaatc atacgcctat tttacctgcc     4740

cactctgaaa cctgtaaagt ccctactctt ctgaagaaac ctgcgtcata cgtgagtgat     4800

tttaaagaaa aacattgctc agctaatcat acggccctta tagctaatct atctcaaatt     4860

ttgcagaggg cagatgaagc atcatctttg cagattctac aggaagaaac taaggtttgt     4920

ctaaatattc tccctttatt tgtggaagct tttgaaagaa agcaagaatg ttcagttgaa     4980

caaatcctga tttcaagaga actgttggta gaccaaaacc tgtggaataa ttgcaaacac     5040

acattaaaac catgtgctgt tgacactttg gtagaacttc aaatgatgat ggaaacaatt     5100

caattcattg aaaacaaaaa aaggcactta gaaggtgaac caacattgcg aagcttgctt     5160

tggtatgatg aaacactgta tgctgagctt cttggaaaac cacgtggatt tcaacagcag     5220

tctaatttct atcctggttt ccaaggaaga ttaaaatata atgcattctg tgagttacag     5280

acttaccatg atcaattagt tgaattgctt gaagaaacaa aaagggaaaa gaattcatac     5340

tatgtattct taaagtacaa acgacaggtt aatgaatgtg aagccataat ggagcattgt     5400

tccgattgct ttgatttttc tctttctgtt ccatttacct gtggagttaa ctttggagat     5460

agtttagaag acctggaaat cttaagaaaa agtactttaa agttgatcaa tgtatgtggg     5520

gactctccta aagttcattc gtatccagga aaacaggacc atctgtggat tatcatagaa     5580

atgatctcct caaaggttaa ttttattaag aacaacgagg cagtacgtgt taaaatatct     5640

ctttatggtc tggaacatat cttttttgat gctgcaaaaa atcttgtttg gaaagagaga     5700

acacaatcct tcagcaaaaa atactcacaa aagaaggacg aagaaaggct actcagagtg     5760

aataaatgtg ccttttctaa gttgcagaag atatatgata ctttgtctaa agatttaaac     5820

aatgaaccaa tttcccctat tgggcttgag gaggatacta taattgcttc cagaaagtca     5880

gatcatccaa taaacgaagc aacaattagc atagaaaatt ctaaatttaa cagtaatttg     5940

cttgcacacc cagatatttg ttgtattagt gagatattgg atcaggctga atttgcagac     6000

cttaaaaaat tacaggatct caccttgaga tgtacagatc acttagaaat tttaaaaaaa     6060

tactttcaga tgctacaaga taataacatg gataatattt ttatcacaga agaaaatgtt     6120

ttagacgtgg tgataaacca cagccatgag gctatcattt taaagcctga agctattgaa     6180

atgtatattg aaatcgtcat ggtctcagaa acaattcact ttcttaaaaa ctcaatagca     6240

aagaaactag acaaacagag gtttcgaggt atgctttggt ttgatttgtc acttcttcct     6300

gagctggttc agtgccaaga aaaaatggct tctttttcat ttcttaaaga taactcaaca     6360

gatgtttgcc tttggaaagt gatagagact gctgtttccg aacttaagaa agatctggat     6420

attatctgca aatataatga agctgttaat tgctcatatg ctattcattt gctctcaaga     6480

gaacttcaag aactttcaga aataaaaaag cttctgaaga agtccaagta ttttatttcc     6540

acatatattg actttgtgcc atatatagca tccataaatt atggaagcac tgtgacagag     6600

ttagaataca actacaatca attttctaca ctgctgaaga atgtaatgtc tgcccctagg     6660

aaagatttag gaaaaatggc ccacattagg aaagtcatga aaacgattga acatatgaag     6720

atgatatgta ctaaaaatgc tgaactaacc atttcctttt tcctatgcca aatgctgtat     6780

aacagaagga agattttaca gctgaagaga aaagaaaaaa tgaatattca tattgtaaaa     6840

cctggggaaa ataacaataa atttagtatt tctacgatgt tgcccccagt atcagagtgc     6900

ataaacaaaa acatctcaaa ttcctctaaa aaacgaccga gcactgtaga caaatgtgaa     6960

gactctcagg aacaacagca agatactact gtttccagtt gtaaaaagct aaaggtagac     7020

atgaaagatg tcacaaaaat caacagagaa aaggcaacat tcaagcatcc aaggactaca     7080

ggatctcatc ccaaaagcga aaacaaaata gtaccaagtt catgtgacag tctgaaaaga     7140

aatcatttaa cgccaaaaaa ggttgaaatg caaagatcac tacctggctc acttttaccc     7200

ttagagaacc caaaagacac ttgcgcatca aagtcggaaa gcaaaataga cttaactgtt     7260

tcatctgatc acttcagtgg acaacaggaa aatttaaata gcatgaagaa aagaaatgtg     7320

aacttcagtg ctgctgaaac aaaaagtgat aagaaagatt gtgctgcttt tgcaatttgt     7380

gaccaaaaaa gtgtacatgg cacattttca ccagaccatg ggacgctttt gcagaaattt     7440

cttaaaaatt ccccagatcc cacccaaaaa tcctgccttt ctgatataaa cccagaaact     7500

gatgtttctc ttgtgcctga tgcgtcggtg ctctcaaagc caattttctg ttttgtgaaa     7560

gatgtccatc ctgatctaga aatgaatgac acagtctttg aacttcaaga taatgatata     7620

gtaaattcat ctattaaaaa ttcctcatgc atgacttctc cagaacccat ctgtatccag     7680

aacaaaattc ctactctgca gataaacaaa ctacagccta cagaaactga gtcagaggac     7740

aaatacatga aggatacatt gaatcccaat actgtgcata cttttggagc atctgggcat     7800

ataaccctta atgtgaatca aggagcagag tactctcttt ctgaacaaca gaatgacaaa     7860

aattcaaaag tcctaatgca gaatgctgcc acatattgga atgaacttcc acagtctgca     7920

tgtaacccaa catataattc ttctgagcat ttatttggaa cttcatatcc atactctgct     7980

tggtgtgttt atcagtacag caacagcaat ggcaatgcca ttacccagac ataccaaggg     8040

ataacatcat atgaagtaca gccatctcct tctgggctgt tgaccacagt tgcaagtact     8100

gcccagggca cacattctaa tcttctgtac tctcaatatt ttacttattt tgcgggggag     8160

ccacaagcaa atggctttgt gccagtgaat gggtattttc aatctcaaat acctgcttct     8220

aattttcggc agccaatttt ttcacaatat gcttctcatc agccattacc acaagctaca     8280

tacccttacc ttcctaatcg atttgtgcct ccagaagttc cttgggttta tgctccatgg     8340

caccaagaat cctttcatcc aggacactga                                      8370


<210>  176
<211>  2789
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Pro Ser Asp Ala Lys Asp Ser Val Asn Gly Asp Leu Leu Leu Asn 
1               5                   10                  15      


Trp Thr Ser Leu Lys Asn Ile Leu Ser Gly Leu Asn Ala Ser Phe Pro 
            20                  25                  30          


Leu His Asn Asn Thr Gly Ser Ser Thr Val Thr Thr Ser Lys Ser Ile 
        35                  40                  45              


Lys Asp Pro Arg Leu Met Arg Arg Glu Glu Ser Met Gly Glu Gln Ser 
    50                  55                  60                  


Ser Thr Ala Gly Leu Asn Glu Val Leu Gln Phe Glu Lys Ser Ser Asp 
65                  70                  75                  80  


Asn Val Asn Ser Glu Ile Lys Ser Thr Pro Ser Asn Ser Ala Ser Ser 
                85                  90                  95      


Ser Glu Val Val Pro Gly Asp Arg Ala Val Leu Thr Asn Gly Leu Asp 
            100                 105                 110         


Thr Pro Cys Phe Lys Thr Ser Val Asn Asp Ser Gln Ser Trp Ala His 
        115                 120                 125             


Asn Met Gly Ser Glu Asp Tyr Asp Cys Ile Pro Pro Asn Lys Val Thr 
    130                 135                 140                 


Met Ala Gly Gln Cys Lys Asp Gln Gly Asn Phe Ser Phe Pro Ile Ser 
145                 150                 155                 160 


Val Ser Asn Val Val Ser Glu Val Glu Asn Gln Asn His Ser Glu Glu 
                165                 170                 175     


Lys Ala Gln Arg Ala Gln Gln Glu Ser Gly Asn Ala Tyr Thr Lys Glu 
            180                 185                 190         


Tyr Ser Ser His Ile Phe Gln Asp Ser Gln Ser Ser Asp Leu Lys Thr 
        195                 200                 205             


Ile Tyr Gln Thr Gly Cys Gln Thr Ser Thr Val Phe Pro Leu Lys Lys 
    210                 215                 220                 


Lys Val Ser Ile Asp Glu Tyr Leu Gln Asn Thr Gly Lys Met Lys Asn 
225                 230                 235                 240 


Phe Ala Asp Leu Glu Asp Ser Ser Lys His Glu Glu Lys Gln Thr Ser 
                245                 250                 255     


Trp Lys Glu Ile Asp Asn Asp Phe Thr Asn Glu Thr Lys Ile Ser Pro 
            260                 265                 270         


Ile Asp Asn Tyr Ile Val Leu His Gln Glu Tyr Lys Glu Ser Glu Ser 
        275                 280                 285             


His Asn Ser Phe Gly Lys Ser Cys Asp Lys Ile Leu Ile Thr Gln Glu 
    290                 295                 300                 


Leu Glu Ile Thr Lys Ser Ser Thr Ser Thr Ile Lys Asp Lys Asp Glu 
305                 310                 315                 320 


Leu Asp His Leu Ala Leu Glu Trp Gln Ile Thr Pro Ser Phe Glu Ser 
                325                 330                 335     


Leu Ser Gln Lys His Pro Gln His Ser Val Glu Tyr Glu Gly Asn Ile 
            340                 345                 350         


His Thr Ser Leu Ala Ile Ala Gln Lys Leu Met Glu Leu Lys Leu Gly 
        355                 360                 365             


Lys Ile Asn Gln Asn Tyr Ala Ser Ile Ile Thr Glu Ala Phe Pro Lys 
    370                 375                 380                 


Pro Lys Asp Ile Pro Gln Ala Lys Glu Met Phe Ile Asp Thr Val Ile 
385                 390                 395                 400 


Ser Ser Tyr Asn Ile Glu Thr Ala His Asp Ser Ser Asn Cys Ser Ile 
                405                 410                 415     


Thr Arg Glu His Ile Cys Val His Arg Lys Asn Glu Asn Glu Pro Val 
            420                 425                 430         


Ser Leu Glu Asn Ile Gln Arg Asp Tyr Lys Glu Thr Ala Tyr Val Glu 
        435                 440                 445             


Asp Arg Gly Gln Asp His Asn Leu Phe Cys Asn Ser Gln Leu Ser Asn 
    450                 455                 460                 


Asp Ile Trp Leu Asn Val Asn Phe Lys Lys Gln Thr Asp Arg Glu Asn 
465                 470                 475                 480 


Gln Asn Glu Ala Lys Glu Asn Ser Ala Ser Cys Val Glu Asn Asn Ile 
                485                 490                 495     


Glu Asn Ile Tyr Gly Asp Lys Lys Gln Asp Ser His Thr Asn Glu Asn 
            500                 505                 510         


Phe Ser Asn Ile Asp Glu Lys Glu Asp Lys Asn Tyr His Asn Ile Glu 
        515                 520                 525             


Ile Leu Ser Ser Glu Glu Phe Ser Thr Lys Phe Asn Leu Ile Cys Arg 
    530                 535                 540                 


Glu Asp Asn Ala Val Ser Ala Ala Thr Ala Leu Leu Glu Ser Glu Glu 
545                 550                 555                 560 


Asp Thr Ile Ser Ala Val Lys Gln Lys Asp Thr Glu Asn Thr Gly Arg 
                565                 570                 575     


Ser Val Glu His Leu Ala Ser Thr Thr Phe Pro Lys Thr Ala Ser Ser 
            580                 585                 590         


Ser Val Cys Val Ala Ser Asn Ala Ala Ile Gln Ile Ala Ser Ala Thr 
        595                 600                 605             


Met Pro Ala Leu Ser Leu Asn Asn Asp Asp His Gln Ile Tyr Gln Phe 
    610                 615                 620                 


Lys Glu Thr Cys Ser Ser Glu Ser Pro Asp Phe Gly Leu Leu Val Lys 
625                 630                 635                 640 


His Arg Val Ser Asp Cys Glu Ile Asp Thr Asp Lys Asn Lys Ser Gln 
                645                 650                 655     


Glu Ser Phe His Gln Ser Ile Asn Glu Asn Leu Val Leu Gln Ser Ile 
            660                 665                 670         


Glu Leu Glu Ser Glu Ile Glu Ile Glu Leu Glu Asp Cys Asp Asp Ala 
        675                 680                 685             


Phe Ile Phe Gln Gln Asp Thr His Ser His Glu Asn Met Leu Cys Glu 
    690                 695                 700                 


Glu Phe Val Thr Ser Tyr Lys Ala Leu Lys Ser Arg Ile Ser Trp Glu 
705                 710                 715                 720 


Gly Leu Leu Ala Leu Asp Asn Gly Glu Met Glu Val Leu Glu Ser Thr 
                725                 730                 735     


Thr Gly Arg Glu Asn Ser Asp Gln His Tyr Ser Lys Glu Ser Asn Tyr 
            740                 745                 750         


Phe Tyr Ser Ser Thr Gln Asn Asn Glu Thr Glu Leu Thr Ser Pro Ile 
        755                 760                 765             


Leu Leu Pro Asp Leu Gln Ile Lys Ile Thr Asn Ile Phe Arg Pro Gly 
    770                 775                 780                 


Phe Ser Pro Thr Ala Asp Ser Leu Ala Leu Lys Asp Ser Phe Cys Thr 
785                 790                 795                 800 


His Val Thr Glu Ala Thr Lys Pro Glu Ile Asn Lys Glu Asp Gly Glu 
                805                 810                 815     


Ile Leu Gly Phe Asp Ile Tyr Ser Gln Pro Phe Gly Glu Asn Ala Asp 
            820                 825                 830         


Tyr Pro Cys Glu Asp Lys Val Asp Asn Ile Arg Gln Glu Ser Gly Pro 
        835                 840                 845             


Val Ser Asn Ser Glu Ile Ser Leu Ser Phe Asp Leu Ser Arg Asn Thr 
    850                 855                 860                 


Asp Val Asn His Thr Ser Glu Asn Gln Asn Ser Glu Ser Leu Phe Thr 
865                 870                 875                 880 


Glu Pro Ser Asn Val Thr Thr Ile Asp Asp Gly Ser Arg Cys Phe Phe 
                885                 890                 895     


Thr Lys Ser Lys Thr Asp Tyr Asn Asp Thr Lys Asn Lys Lys Glu Val 
            900                 905                 910         


Glu Ser Arg Ile Ser Lys Arg Lys Leu His Ile Ser Ser Arg Asp Gln 
        915                 920                 925             


Asn Ile Pro His Lys Asp Leu Arg Arg His Lys Ile Tyr Gly Arg Lys 
    930                 935                 940                 


Arg Arg Leu Thr Ser Gln Asp Ser Ser Glu Cys Phe Ser Ser Leu Ser 
945                 950                 955                 960 


Gln Gly Arg Ile Lys Thr Phe Ser Gln Ser Glu Lys His Ile Lys Ser 
                965                 970                 975     


Val Leu Asn Ile Leu Ser Asp Glu Ala Ser Leu Cys Lys Ser Lys Cys 
            980                 985                 990         


Leu Ser Arg Lys Leu Asp Lys Ala  Val Val His Leu Lys  Lys Ala His 
        995                 1000                 1005             


Arg Arg  Val His Thr Ser Leu  Gln Leu Ile Thr Lys  Val Gly Glu 
    1010                 1015                 1020             


Glu Arg  Lys Gly Pro Leu Pro  Lys Ser Tyr Ala Val  Ile Cys Asn 
    1025                 1030                 1035             


Asn Phe  Trp Glu Ser Cys Asp  Leu Gln Gly Tyr Ser  Ser Val Ser 
    1040                 1045                 1050             


Gln Arg  Lys Tyr Tyr Ser Thr  Lys His Phe Ser Ser  Lys Arg Lys 
    1055                 1060                 1065             


Tyr Asp  Lys Arg Arg Lys Lys  Arg Ala Pro Lys Ala  Asp Ile Ser 
    1070                 1075                 1080             


Lys Ser  Leu Thr His Val Ser  Lys His Lys Ser Tyr  Lys Thr Ser 
    1085                 1090                 1095             


Gly Glu  Lys Lys Cys Leu Ser  Arg Lys Ser Met Ala  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Ser His Pro Thr Thr  Ser His Met Gly Glu  Phe Cys Asn 
    1115                 1120                 1125             


Gln Glu  His Pro Glu Ser Gln  Leu Pro Val Ser Ser  Thr Ser Gln 
    1130                 1135                 1140             


Ser Thr  Ser Gln Ser Val Tyr  Tyr Asn Ser Ser Val  Ser Asn Pro 
    1145                 1150                 1155             


Ser Leu  Ser Glu Glu His Gln  Pro Phe Ser Gly Lys  Thr Ala Tyr 
    1160                 1165                 1170             


Leu Phe  Ser Pro Asp His Ser  Asp Glu Lys Leu Ile  Glu Lys Glu 
    1175                 1180                 1185             


Asn Gln  Ile Asp Thr Ala Phe  Leu Ser Ser Thr Ser  Lys Tyr Glu 
    1190                 1195                 1200             


Lys Leu  Glu Lys His Ser Ala  Asn His Asn Val Lys  Asp Ala Thr 
    1205                 1210                 1215             


Lys Glu  Asn Ser Cys Asp Ala  Asn Glu Val Ile Asn  Glu Ser Asn 
    1220                 1225                 1230             


Ser Val  Ser Leu Ser Cys Ile  Lys Glu Asn Ile Asn  Ser Ser Thr 
    1235                 1240                 1245             


Gly Asn  Asp Cys Asp Ala Thr  Cys Ile Gly His Thr  Lys Ala Lys 
    1250                 1255                 1260             


Thr Asp  Val Leu Ile Ser Val  Leu Asp Ser Asn Val  Lys His Phe 
    1265                 1270                 1275             


Leu Asn  Asp Leu Tyr Gln Gln  Gly Asn Leu Ile Leu  Ser Asp Cys 
    1280                 1285                 1290             


Lys Arg  Asn Leu Glu Val Lys  Trp Thr Asp Pro Ile  Glu Arg Pro 
    1295                 1300                 1305             


Lys Gln  Ser Ile Ile Thr Gly  Asn Phe Leu Met Gly  Pro Leu Asn 
    1310                 1315                 1320             


Leu Thr  Leu Ile Ala Ser Lys  Lys Tyr Ser Ile Pro  Gln Val Ser 
    1325                 1330                 1335             


Ala Ala  Ala Val Thr Asp Ser  Glu Gly Glu Ser Ser  Lys Ser Tyr 
    1340                 1345                 1350             


Leu Asp  Lys Gln Arg Ile Leu  Thr Val Asp Ser Phe  Ala Ala Ser 
    1355                 1360                 1365             


Ser Thr  Val Pro His Cys Glu  Gln Ser Cys Arg Glu  Lys Glu Leu 
    1370                 1375                 1380             


Leu Lys  Thr Glu Gln Cys Ser  Ser Gly Asn Cys Leu  His Thr Asp 
    1385                 1390                 1395             


Gly Asn  Glu Thr Asn Val Thr  Glu Asn Tyr Glu Leu  Asp Val Ala 
    1400                 1405                 1410             


Ser Gly  Thr Glu Glu Asp Lys  Ser Tyr Gly Glu Asn  Ile Val Glu 
    1415                 1420                 1425             


Leu Ser  Ser Ser Asp Ser Ser  Leu Leu Leu Arg Asp  Asn Val Lys 
    1430                 1435                 1440             


Gly Ser  Ser Ser Glu Thr Cys  Ile Val Lys Lys Asp  Thr Glu Asp 
    1445                 1450                 1455             


Arg Ile  Thr Trp Lys Val Lys  Gln Ala Glu Lys Ala  Lys Asp Ser 
    1460                 1465                 1470             


Val Tyr  Lys Arg Ser Met Thr  Glu Gly Ser Thr Val  Asn Thr Glu 
    1475                 1480                 1485             


Tyr Lys  Asn Gln Lys Asn Gln  Ile Ser Glu Glu Ser  Cys Leu Asn 
    1490                 1495                 1500             


Glu Lys  Ile Ile Thr Thr Asn  Leu Ile Asp Ser His  Leu Ser Thr 
    1505                 1510                 1515             


Lys Asn  Thr Thr Thr Glu Ser  Val Pro Leu Lys Asn  Thr Val Ser 
    1520                 1525                 1530             


Asn Pro  Leu Asn Lys Arg Glu  Lys Lys Gly Glu Ile  Lys Val Ser 
    1535                 1540                 1545             


Lys Asp  Ser Gln Ser Asp Leu  Thr Leu His Ser Glu  Ile Ala Tyr 
    1550                 1555                 1560             


Ile Ser  Lys Pro Gly Ile Leu  Gly Val Asn His Thr  Pro Ile Leu 
    1565                 1570                 1575             


Pro Ala  His Ser Glu Thr Cys  Lys Val Pro Thr Leu  Leu Lys Lys 
    1580                 1585                 1590             


Pro Ala  Ser Tyr Val Ser Asp  Phe Lys Glu Lys His  Cys Ser Ala 
    1595                 1600                 1605             


Asn His  Thr Ala Leu Ile Ala  Asn Leu Ser Gln Ile  Leu Gln Arg 
    1610                 1615                 1620             


Ala Asp  Glu Ala Ser Ser Leu  Gln Ile Leu Gln Glu  Glu Thr Lys 
    1625                 1630                 1635             


Val Cys  Leu Asn Ile Leu Pro  Leu Phe Val Glu Ala  Phe Glu Arg 
    1640                 1645                 1650             


Lys Gln  Glu Cys Ser Val Glu  Gln Ile Leu Ile Ser  Arg Glu Leu 
    1655                 1660                 1665             


Leu Val  Asp Gln Asn Leu Trp  Asn Asn Cys Lys His  Thr Leu Lys 
    1670                 1675                 1680             


Pro Cys  Ala Val Asp Thr Leu  Val Glu Leu Gln Met  Met Met Glu 
    1685                 1690                 1695             


Thr Ile  Gln Phe Ile Glu Asn  Lys Lys Arg His Leu  Glu Gly Glu 
    1700                 1705                 1710             


Pro Thr  Leu Arg Ser Leu Leu  Trp Tyr Asp Glu Thr  Leu Tyr Ala 
    1715                 1720                 1725             


Glu Leu  Leu Gly Lys Pro Arg  Gly Phe Gln Gln Gln  Ser Asn Phe 
    1730                 1735                 1740             


Tyr Pro  Gly Phe Gln Gly Arg  Leu Lys Tyr Asn Ala  Phe Cys Glu 
    1745                 1750                 1755             


Leu Gln  Thr Tyr His Asp Gln  Leu Val Glu Leu Leu  Glu Glu Thr 
    1760                 1765                 1770             


Lys Arg  Glu Lys Asn Ser Tyr  Tyr Val Phe Leu Lys  Tyr Lys Arg 
    1775                 1780                 1785             


Gln Val  Asn Glu Cys Glu Ala  Ile Met Glu His Cys  Ser Asp Cys 
    1790                 1795                 1800             


Phe Asp  Phe Ser Leu Ser Val  Pro Phe Thr Cys Gly  Val Asn Phe 
    1805                 1810                 1815             


Gly Asp  Ser Leu Glu Asp Leu  Glu Ile Leu Arg Lys  Ser Thr Leu 
    1820                 1825                 1830             


Lys Leu  Ile Asn Val Cys Gly  Asp Ser Pro Lys Val  His Ser Tyr 
    1835                 1840                 1845             


Pro Gly  Lys Gln Asp His Leu  Trp Ile Ile Ile Glu  Met Ile Ser 
    1850                 1855                 1860             


Ser Lys  Val Asn Phe Ile Lys  Asn Asn Glu Ala Val  Arg Val Lys 
    1865                 1870                 1875             


Ile Ser  Leu Tyr Gly Leu Glu  His Ile Phe Phe Asp  Ala Ala Lys 
    1880                 1885                 1890             


Asn Leu  Val Trp Lys Glu Arg  Thr Gln Ser Phe Ser  Lys Lys Tyr 
    1895                 1900                 1905             


Ser Gln  Lys Lys Asp Glu Glu  Arg Leu Leu Arg Val  Asn Lys Cys 
    1910                 1915                 1920             


Ala Phe  Ser Lys Leu Gln Lys  Ile Tyr Asp Thr Leu  Ser Lys Asp 
    1925                 1930                 1935             


Leu Asn  Asn Glu Pro Ile Ser  Pro Ile Gly Leu Glu  Glu Asp Thr 
    1940                 1945                 1950             


Ile Ile  Ala Ser Arg Lys Ser  Asp His Pro Ile Asn  Glu Ala Thr 
    1955                 1960                 1965             


Ile Ser  Ile Glu Asn Ser Lys  Phe Asn Ser Asn Leu  Leu Ala His 
    1970                 1975                 1980             


Pro Asp  Ile Cys Cys Ile Ser  Glu Ile Leu Asp Gln  Ala Glu Phe 
    1985                 1990                 1995             


Ala Asp  Leu Lys Lys Leu Gln  Asp Leu Thr Leu Arg  Cys Thr Asp 
    2000                 2005                 2010             


His Leu  Glu Ile Leu Lys Lys  Tyr Phe Gln Met Leu  Gln Asp Asn 
    2015                 2020                 2025             


Asn Met  Asp Asn Ile Phe Ile  Thr Glu Glu Asn Val  Leu Asp Val 
    2030                 2035                 2040             


Val Ile  Asn His Ser His Glu  Ala Ile Ile Leu Lys  Pro Glu Ala 
    2045                 2050                 2055             


Ile Glu  Met Tyr Ile Glu Ile  Val Met Val Ser Glu  Thr Ile His 
    2060                 2065                 2070             


Phe Leu  Lys Asn Ser Ile Ala  Lys Lys Leu Asp Lys  Gln Arg Phe 
    2075                 2080                 2085             


Arg Gly  Met Leu Trp Phe Asp  Leu Ser Leu Leu Pro  Glu Leu Val 
    2090                 2095                 2100             


Gln Cys  Gln Glu Lys Met Ala  Ser Phe Ser Phe Leu  Lys Asp Asn 
    2105                 2110                 2115             


Ser Thr  Asp Val Cys Leu Trp  Lys Val Ile Glu Thr  Ala Val Ser 
    2120                 2125                 2130             


Glu Leu  Lys Lys Asp Leu Asp  Ile Ile Cys Lys Tyr  Asn Glu Ala 
    2135                 2140                 2145             


Val Asn  Cys Ser Tyr Ala Ile  His Leu Leu Ser Arg  Glu Leu Gln 
    2150                 2155                 2160             


Glu Leu  Ser Glu Ile Lys Lys  Leu Leu Lys Lys Ser  Lys Tyr Phe 
    2165                 2170                 2175             


Ile Ser  Thr Tyr Ile Asp Phe  Val Pro Tyr Ile Ala  Ser Ile Asn 
    2180                 2185                 2190             


Tyr Gly  Ser Thr Val Thr Glu  Leu Glu Tyr Asn Tyr  Asn Gln Phe 
    2195                 2200                 2205             


Ser Thr  Leu Leu Lys Asn Val  Met Ser Ala Pro Arg  Lys Asp Leu 
    2210                 2215                 2220             


Gly Lys  Met Ala His Ile Arg  Lys Val Met Lys Thr  Ile Glu His 
    2225                 2230                 2235             


Met Lys  Met Ile Cys Thr Lys  Asn Ala Glu Leu Thr  Ile Ser Phe 
    2240                 2245                 2250             


Phe Leu  Cys Gln Met Leu Tyr  Asn Arg Arg Lys Ile  Leu Gln Leu 
    2255                 2260                 2265             


Lys Arg  Lys Glu Lys Met Asn  Ile His Ile Val Lys  Pro Gly Glu 
    2270                 2275                 2280             


Asn Asn  Asn Lys Phe Ser Ile  Ser Thr Met Leu Pro  Pro Val Ser 
    2285                 2290                 2295             


Glu Cys  Ile Asn Lys Asn Ile  Ser Asn Ser Ser Lys  Lys Arg Pro 
    2300                 2305                 2310             


Ser Thr  Val Asp Lys Cys Glu  Asp Ser Gln Glu Gln  Gln Gln Asp 
    2315                 2320                 2325             


Thr Thr  Val Ser Ser Cys Lys  Lys Leu Lys Val Asp  Met Lys Asp 
    2330                 2335                 2340             


Val Thr  Lys Ile Asn Arg Glu  Lys Ala Thr Phe Lys  His Pro Arg 
    2345                 2350                 2355             


Thr Thr  Gly Ser His Pro Lys  Ser Glu Asn Lys Ile  Val Pro Ser 
    2360                 2365                 2370             


Ser Cys  Asp Ser Leu Lys Arg  Asn His Leu Thr Pro  Lys Lys Val 
    2375                 2380                 2385             


Glu Met  Gln Arg Ser Leu Pro  Gly Ser Leu Leu Pro  Leu Glu Asn 
    2390                 2395                 2400             


Pro Lys  Asp Thr Cys Ala Ser  Lys Ser Glu Ser Lys  Ile Asp Leu 
    2405                 2410                 2415             


Thr Val  Ser Ser Asp His Phe  Ser Gly Gln Gln Glu  Asn Leu Asn 
    2420                 2425                 2430             


Ser Met  Lys Lys Arg Asn Val  Asn Phe Ser Ala Ala  Glu Thr Lys 
    2435                 2440                 2445             


Ser Asp  Lys Lys Asp Cys Ala  Ala Phe Ala Ile Cys  Asp Gln Lys 
    2450                 2455                 2460             


Ser Val  His Gly Thr Phe Ser  Pro Asp His Gly Thr  Leu Leu Gln 
    2465                 2470                 2475             


Lys Phe  Leu Lys Asn Ser Pro  Asp Pro Thr Gln Lys  Ser Cys Leu 
    2480                 2485                 2490             


Ser Asp  Ile Asn Pro Glu Thr  Asp Val Ser Leu Val  Pro Asp Ala 
    2495                 2500                 2505             


Ser Val  Leu Ser Lys Pro Ile  Phe Cys Phe Val Lys  Asp Val His 
    2510                 2515                 2520             


Pro Asp  Leu Glu Met Asn Asp  Thr Val Phe Glu Leu  Gln Asp Asn 
    2525                 2530                 2535             


Asp Ile  Val Asn Ser Ser Ile  Lys Asn Ser Ser Cys  Met Thr Ser 
    2540                 2545                 2550             


Pro Glu  Pro Ile Cys Ile Gln  Asn Lys Ile Pro Thr  Leu Gln Ile 
    2555                 2560                 2565             


Asn Lys  Leu Gln Pro Thr Glu  Thr Glu Ser Glu Asp  Lys Tyr Met 
    2570                 2575                 2580             


Lys Asp  Thr Leu Asn Pro Asn  Thr Val His Thr Phe  Gly Ala Ser 
    2585                 2590                 2595             


Gly His  Ile Thr Leu Asn Val  Asn Gln Gly Ala Glu  Tyr Ser Leu 
    2600                 2605                 2610             


Ser Glu  Gln Gln Asn Asp Lys  Asn Ser Lys Val Leu  Met Gln Asn 
    2615                 2620                 2625             


Ala Ala  Thr Tyr Trp Asn Glu  Leu Pro Gln Ser Ala  Cys Asn Pro 
    2630                 2635                 2640             


Thr Tyr  Asn Ser Ser Glu His  Leu Phe Gly Thr Ser  Tyr Pro Tyr 
    2645                 2650                 2655             


Ser Ala  Trp Cys Val Tyr Gln  Tyr Ser Asn Ser Asn  Gly Asn Ala 
    2660                 2665                 2670             


Ile Thr  Gln Thr Tyr Gln Gly  Ile Thr Ser Tyr Glu  Val Gln Pro 
    2675                 2680                 2685             


Ser Pro  Ser Gly Leu Leu Thr  Thr Val Ala Ser Thr  Ala Gln Gly 
    2690                 2695                 2700             


Thr His  Ser Asn Leu Leu Tyr  Ser Gln Tyr Phe Thr  Tyr Phe Ala 
    2705                 2710                 2715             


Gly Glu  Pro Gln Ala Asn Gly  Phe Val Pro Val Asn  Gly Tyr Phe 
    2720                 2725                 2730             


Gln Ser  Gln Ile Pro Ala Ser  Asn Phe Arg Gln Pro  Ile Phe Ser 
    2735                 2740                 2745             


Gln Tyr  Ala Ser His Gln Pro  Leu Pro Gln Ala Thr  Tyr Pro Tyr 
    2750                 2755                 2760             


Leu Pro  Asn Arg Phe Val Pro  Pro Glu Val Pro Trp  Val Tyr Ala 
    2765                 2770                 2775             


Pro Trp  His Gln Glu Ser Phe  His Pro Gly His 
    2780                 2785                 


<210>  177
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  177
atgcctcacc ttatggaaag gatggtgggc tctggcctcc tgtggctggc cttggtctcc       60

tgcattctga cccaggcatc tgcagtgcag cgaggttatg gaaaccccat tgaagccagt      120

tcgtatgggc tggacctgga ctgcggagct cctggcaccc cagaggctca tgtctgtttt      180

gacccctgtc agaattacac cctcctggat gaacccttcc gaagcacaga gaactcagca      240

gggtcccagg ggtgcgataa aaacatgagc ggctggtacc gctttgtagg ggaaggagga      300

gtaaggatgt cggagacctg tgtccaggtg caccgatgcc agacagacgc tcccatgtgg      360

ctgaatggga cccaccctgc ccttggggat ggcatcacca accacactgc ctgtgcccat      420

tggagtggca actgctgttt ctggaaaaca gaggtgctgg tgaaggcctg cccaggcggg      480

taccatgtgt accggttgga aggcactccc tggtgtaatc tgagatactg cacagttcca      540

cgagacccat ccactgtgga ggacaagtgt gagaaggcct gccgccccga ggaggagtgc      600

cttgccctca acagcacctg gggctgtttc tgcagacagg acctcaatag ttctgatgtc      660

cacagtttgc agcctcagct agactgtggg cccagggaga tcaaggtgaa ggtggacaaa      720

tgtttgctgg gaggcctggg tttgggggag gaggtcattg cctacctgcg agacccaaac      780

tgcagcagca tcttgcagac agaggagagg aactgggtat ctgtgaccag ccccgtccag      840

gctagtgcct gcaggaacat tctggagaga aatcaaaccc atgccatcta caaaaacacc      900

ctctccttgg tcaatgattt catcatcaga gacaccatcc tcaacatcaa cttccaatgt      960

gcctacccac tggacatgaa agtcagcctc caagctgcct tgcagcccat tgtaagttcc     1020

ctgaacgtca gtgtggacgg gaatggagag ttcattgtca ggatggccct cttccaagac     1080

cagaactaca cgaatcctta cgaaggggat gcagttgaac tgtctgttga gtccgtgctg     1140

tatgtgggtg ccatcttgga acaaggggac acctcccggt ttaacctggt gttgaggaac     1200

tgctatgcca cccccactga agacaaggct gaccttgtga agtatttcat catcagaaac     1260

agctgctcaa atcaacgtga ttccaccatc cacgtggagg agaatgggca gtcctcggaa     1320

agccggttct cagttcagat gttcatgttt gctggacatt atgacctagt tttcctgcat     1380

tgtgagattc atctctgtga ttctcttaat gaacagtgcc agccttcttg ctcaagaagt     1440

caagtccgca gtgaagtacc ggccatcgac ctagcccggg ttctagattt ggggcccatc     1500

actcggagag gtgcacagtc tcccggtgtc atgaatggaa cccctagcac tgcagggttc     1560

ctggtggcct ggcctatggt cctcctgact gtcctcctgg cttggctgtt ctga           1614


<210>  178
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys 
            180                 185                 190         


Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly 
        195                 200                 205             


Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln 
    210                 215                 220                 


Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys 
225                 230                 235                 240 


Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu 
                245                 250                 255     


Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp 
            260                 265                 270         


Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu 
        275                 280                 285             


Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val 
    290                 295                 300                 


Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys 
305                 310                 315                 320 


Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro 
                325                 330                 335     


Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile 
            340                 345                 350         


Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu 
        355                 360                 365             


Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala 
    370                 375                 380                 


Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn 
385                 390                 395                 400 


Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe 
                405                 410                 415     


Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val 
            420                 425                 430         


Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe 
        435                 440                 445             


Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His 
    450                 455                 460                 


Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser 
465                 470                 475                 480 


Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp 
                485                 490                 495     


Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn 
            500                 505                 510         


Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu 
        515                 520                 525             


Leu Thr Val Leu Leu Ala Trp Leu Phe 
    530                 535         


<210>  179
<211>  2568
<212>  DNA
<213>  Homo sapiens

<400>  179
atgtcggcgc cgtcggagga ggaggagtac gcgcggctgg tgatggaggc gcagccggag       60

tggctgcgcg ccgaggtgaa gcggctgtcc cacgagctgg ccgagaccac gcgtgagaag      120

atccaggcgg ccgagtacgg gctggcggtg ctcgaggaga agcaccagct caagctgcag      180

ttcgaggagc tcgaggtgga ctatgaggct atccgcagcg agatggagca gctcaaggag      240

gcctttggac aagcacacac aaaccacaag aaggtggctg ctgacggaga gagccgggag      300

gagagcctga tccaggagtc ggcctccaag gagcagtact acgtgcggaa ggtgctagag      360

ctgcagacgg agctgaagca gttgcgcaat gtcctcacca acacgcagtc ggagaatgag      420

cgcctggcct ctgtggccca ggagctgaag gagatcaacc agaatgtgga gatccagcgt      480

ggccgcctgc gggatgacat caaggagtac aaattccggg aagctcgtct gctgcaggac      540

tactcggaac tggaggagga gaacatcagc ctgcagaagc aagtgtctgt gctcagacag      600

aaccaggtgg agtttgaggg cctcaagcat gagatcaagc gtctggagga ggagaccgag      660

tacctcaaca gccagctgga ggatgccatc cgcctcaagg agatctcaga gcggcagctg      720

gaggaggcgc tggagaccct gaagacggag cgcgaacaga agaacagcct gcgcaaggag      780

ctgtcacact acatgagcat caatgactcc ttctacacca gccacctgca tgtctcgctg      840

gatggcctca agttcagtga cgatgctgcc gagcccaaca acgatgccga ggccctggtc      900

aatggctttg agcacggcgg cctggccaag ctgccactgg acaacaagac ctccacgccc      960

aagaaggagg gcctcgcacc gccctccccc agcctcgtct ccgacctact cagtgagctc     1020

aacatctctg agatccagaa gctgaagcag cagctgatgc agatggagcg ggaaaaggcg     1080

ggcctgctgg caacgctgca ggacacacag aagcagctgg agcacacgcg gggctccctg     1140

tcagaacagc aggagaaggt gacccgcctc acagagaatc tgagtgccct gcggcgcctg     1200

caggccagca aggagcggca gacagccctg gacaacgaga aggaccgtga cagccatgag     1260

gatggggact actacgaggt ggacatcaac gggcctgaga tcttggcctg caagtaccat     1320

gtggctgtgg ctgaggctgg cgagctccgc gagcagctca aggcactgcg cagcacgcac     1380

gaggctcgtg aggcccagca cgccgaggag aagggccgct atgaggctga gggccaggca     1440

ctcacggaga aggtctccct gctagagaag gccagccgcc aggaccgcga gctgctggcc     1500

cggctggaga aggagctaaa gaaggtgagc gacgtcgccg gcgagacaca gggcagcctg     1560

agtgtggccc aggatgagct ggtgaccttc agtgaggagc tggccaatct ctaccaccac     1620

gtgtgcatgt gcaacaatga gacacccaac cgtgtcatgc tggactacta ccgcgagggc     1680

cagggcgggg ccggccgcac cagtcccggg ggccgcacca gccccgaggc gcgtggccgg     1740

cgctcaccca tcctcctacc caaggggctg ctggctcctg aggcgggccg agcagatggt     1800

gggacggggg acagcagccc ctcgcctggc tcctcactgc catcacccct gagtgaccca     1860

cgccgggagc ccatgaacat ctacaacctg atcgctatca tccgtgacca gatcaagcac     1920

ctgcaggcag ccgtggaccg caccacggag ctgtcacgcc agcgcattgc ctctcaggag     1980

ctgggccccg ccgtggacaa ggacaaggaa gcgcttatgg aggagatcct caagctgaag     2040

tcgctgctca gcaccaagcg ggagcagatc accacgctgc gcactgtgct caaggccaac     2100

aagcagacgg ccgaggtggc ccttgccaac ctgaagagca agtatgagaa tgagaaggcc     2160

atggttaccg agaccatgat gaagctgcgc aatgagctca aggccctcaa ggaggacgca     2220

gccaccttct cctcgctgcg tgctatgttt gccaccaggt gtgacgagta cattacacag     2280

ctggatgaga tgcagcggca gctggcggct gctgaggacg agaagaagac gctgaactcg     2340

ctgctgcgca tggccatcca gcagaagctg gcgctgaccc agcggctgga gctgctcgag     2400

ctggaccatg agcagacccg gcgtggccgt gccaaagccg ccccgaagac caagccagcc     2460

acaccgagcg taagtcacac ctgtgcctgt gccagcgaca gggccgaggg caccgggctg     2520

gccaaccagg tgttctgcag cgagaagcac agcatttact gtgattag                  2568


<210>  180
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Ser Ala Pro Ser Glu Glu Glu Glu Tyr Ala Arg Leu Val Met Glu 
1               5                   10                  15      


Ala Gln Pro Glu Trp Leu Arg Ala Glu Val Lys Arg Leu Ser His Glu 
            20                  25                  30          


Leu Ala Glu Thr Thr Arg Glu Lys Ile Gln Ala Ala Glu Tyr Gly Leu 
        35                  40                  45              


Ala Val Leu Glu Glu Lys His Gln Leu Lys Leu Gln Phe Glu Glu Leu 
    50                  55                  60                  


Glu Val Asp Tyr Glu Ala Ile Arg Ser Glu Met Glu Gln Leu Lys Glu 
65                  70                  75                  80  


Ala Phe Gly Gln Ala His Thr Asn His Lys Lys Val Ala Ala Asp Gly 
                85                  90                  95      


Glu Ser Arg Glu Glu Ser Leu Ile Gln Glu Ser Ala Ser Lys Glu Gln 
            100                 105                 110         


Tyr Tyr Val Arg Lys Val Leu Glu Leu Gln Thr Glu Leu Lys Gln Leu 
        115                 120                 125             


Arg Asn Val Leu Thr Asn Thr Gln Ser Glu Asn Glu Arg Leu Ala Ser 
    130                 135                 140                 


Val Ala Gln Glu Leu Lys Glu Ile Asn Gln Asn Val Glu Ile Gln Arg 
145                 150                 155                 160 


Gly Arg Leu Arg Asp Asp Ile Lys Glu Tyr Lys Phe Arg Glu Ala Arg 
                165                 170                 175     


Leu Leu Gln Asp Tyr Ser Glu Leu Glu Glu Glu Asn Ile Ser Leu Gln 
            180                 185                 190         


Lys Gln Val Ser Val Leu Arg Gln Asn Gln Val Glu Phe Glu Gly Leu 
        195                 200                 205             


Lys His Glu Ile Lys Arg Leu Glu Glu Glu Thr Glu Tyr Leu Asn Ser 
    210                 215                 220                 


Gln Leu Glu Asp Ala Ile Arg Leu Lys Glu Ile Ser Glu Arg Gln Leu 
225                 230                 235                 240 


Glu Glu Ala Leu Glu Thr Leu Lys Thr Glu Arg Glu Gln Lys Asn Ser 
                245                 250                 255     


Leu Arg Lys Glu Leu Ser His Tyr Met Ser Ile Asn Asp Ser Phe Tyr 
            260                 265                 270         


Thr Ser His Leu His Val Ser Leu Asp Gly Leu Lys Phe Ser Asp Asp 
        275                 280                 285             


Ala Ala Glu Pro Asn Asn Asp Ala Glu Ala Leu Val Asn Gly Phe Glu 
    290                 295                 300                 


His Gly Gly Leu Ala Lys Leu Pro Leu Asp Asn Lys Thr Ser Thr Pro 
305                 310                 315                 320 


Lys Lys Glu Gly Leu Ala Pro Pro Ser Pro Ser Leu Val Ser Asp Leu 
                325                 330                 335     


Leu Ser Glu Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu 
            340                 345                 350         


Met Gln Met Glu Arg Glu Lys Ala Gly Leu Leu Ala Thr Leu Gln Asp 
        355                 360                 365             


Thr Gln Lys Gln Leu Glu His Thr Arg Gly Ser Leu Ser Glu Gln Gln 
    370                 375                 380                 


Glu Lys Val Thr Arg Leu Thr Glu Asn Leu Ser Ala Leu Arg Arg Leu 
385                 390                 395                 400 


Gln Ala Ser Lys Glu Arg Gln Thr Ala Leu Asp Asn Glu Lys Asp Arg 
                405                 410                 415     


Asp Ser His Glu Asp Gly Asp Tyr Tyr Glu Val Asp Ile Asn Gly Pro 
            420                 425                 430         


Glu Ile Leu Ala Cys Lys Tyr His Val Ala Val Ala Glu Ala Gly Glu 
        435                 440                 445             


Leu Arg Glu Gln Leu Lys Ala Leu Arg Ser Thr His Glu Ala Arg Glu 
    450                 455                 460                 


Ala Gln His Ala Glu Glu Lys Gly Arg Tyr Glu Ala Glu Gly Gln Ala 
465                 470                 475                 480 


Leu Thr Glu Lys Val Ser Leu Leu Glu Lys Ala Ser Arg Gln Asp Arg 
                485                 490                 495     


Glu Leu Leu Ala Arg Leu Glu Lys Glu Leu Lys Lys Val Ser Asp Val 
            500                 505                 510         


Ala Gly Glu Thr Gln Gly Ser Leu Ser Val Ala Gln Asp Glu Leu Val 
        515                 520                 525             


Thr Phe Ser Glu Glu Leu Ala Asn Leu Tyr His His Val Cys Met Cys 
    530                 535                 540                 


Asn Asn Glu Thr Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Glu Gly 
545                 550                 555                 560 


Gln Gly Gly Ala Gly Arg Thr Ser Pro Gly Gly Arg Thr Ser Pro Glu 
                565                 570                 575     


Ala Arg Gly Arg Arg Ser Pro Ile Leu Leu Pro Lys Gly Leu Leu Ala 
            580                 585                 590         


Pro Glu Ala Gly Arg Ala Asp Gly Gly Thr Gly Asp Ser Ser Pro Ser 
        595                 600                 605             


Pro Gly Ser Ser Leu Pro Ser Pro Leu Ser Asp Pro Arg Arg Glu Pro 
    610                 615                 620                 


Met Asn Ile Tyr Asn Leu Ile Ala Ile Ile Arg Asp Gln Ile Lys His 
625                 630                 635                 640 


Leu Gln Ala Ala Val Asp Arg Thr Thr Glu Leu Ser Arg Gln Arg Ile 
                645                 650                 655     


Ala Ser Gln Glu Leu Gly Pro Ala Val Asp Lys Asp Lys Glu Ala Leu 
            660                 665                 670         


Met Glu Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Thr Lys Arg Glu 
        675                 680                 685             


Gln Ile Thr Thr Leu Arg Thr Val Leu Lys Ala Asn Lys Gln Thr Ala 
    690                 695                 700                 


Glu Val Ala Leu Ala Asn Leu Lys Ser Lys Tyr Glu Asn Glu Lys Ala 
705                 710                 715                 720 


Met Val Thr Glu Thr Met Met Lys Leu Arg Asn Glu Leu Lys Ala Leu 
                725                 730                 735     


Lys Glu Asp Ala Ala Thr Phe Ser Ser Leu Arg Ala Met Phe Ala Thr 
            740                 745                 750         


Arg Cys Asp Glu Tyr Ile Thr Gln Leu Asp Glu Met Gln Arg Gln Leu 
        755                 760                 765             


Ala Ala Ala Glu Asp Glu Lys Lys Thr Leu Asn Ser Leu Leu Arg Met 
    770                 775                 780                 


Ala Ile Gln Gln Lys Leu Ala Leu Thr Gln Arg Leu Glu Leu Leu Glu 
785                 790                 795                 800 


Leu Asp His Glu Gln Thr Arg Arg Gly Arg Ala Lys Ala Ala Pro Lys 
                805                 810                 815     


Thr Lys Pro Ala Thr Pro Ser Val Ser His Thr Cys Ala Cys Ala Ser 
            820                 825                 830         


Asp Arg Ala Glu Gly Thr Gly Leu Ala Asn Gln Val Phe Cys Ser Glu 
        835                 840                 845             


Lys His Ser Ile Tyr Cys Asp 
    850                 855 


<210>  181
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  181
atggccggcc tcaactccct ggaggcggtg aaacgcaaga tccaggccct gcagcagcag       60

gcggacgagg cggaagaccg cgcgcagggc ctgcagcggg agctggacgg cgagcgcgag      120

cggcgcgaga aagctgaagg tgatgtggcc gccctcaacc gacgcatcca gctcgttgag      180

gaggagttgg acagggctca ggaacgactg gccacggccc tgcagaagct ggaggaggca      240

gaaaaagctg cagatgagag tgagagagga atgaaggtga tagaaaaccg ggccatgaag      300

gatgaggaga agatggagat tcaggagatg cagctcaaag aggccaagca cattgcggaa      360

gaggctgacc gcaaatacga ggaggtagct cgtaagctgg tcatcctgga gggtgagctg      420

gagagggcag aggagcgtgc ggaggtgtct gaactaaaat gtggtgacct ggaagaagaa      480

ctcaagaatg ttactaacaa tctgaaatct ctggaggctg catctgaaaa gtattctgaa      540

aaggaggaca aatatgaaga agaaattaaa cttctgtctg acaaactgaa agaggctgag      600

acccgtgctg aatttgcaga gagaacggtt gcaaaactgg aaaagacaat tgatgacctg      660

gaagagaaac ttgcccaggc caaagaagag aacgtgggct tacatcagac actggatcag      720

acactaaacg aacttaactg tatataa                                          747


<210>  182
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Gly Leu Asn Ser Leu Glu Ala Val Lys Arg Lys Ile Gln Ala 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp Gly Glu Arg Glu Arg Arg Glu Lys Ala Glu Gly Asp 
        35                  40                  45              


Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Ala Ser Glu 
                165                 170                 175     


Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Lys Leu 
    210                 215                 220                 


Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Asn Glu Leu Asn Cys Ile 
                245             


<210>  183
<211>  2514
<212>  DNA
<213>  Homo sapiens

<400>  183
atgaaccact tggaggggtc tgcggaggtg gaggtgaccg acgaggcggc aggtggggag       60

gtgaacgagt cggtggaggc cgacctggag caccccgagg tggaagagga acagcagcag      120

ccgccgcagc agcagcacta tgtgggccgc caccagcgcg ggcgagccct cgaggacctc      180

cgcgcccagc tcggccagga ggaagaggag cgcggggaat gcctggcgcg ctcagccagc      240

acggagagcg gcttccacaa ccacacggac accgccgagg gcgacgtgat cgccgcggcc      300

cgcgacggct acgatgcgga gcgcgcgcag gaccccgagg acgagagcgc ctatgctgtg      360

cagtaccggc ccgaggccga ggagtacacg gagcaggcag aggccgagca cgccgaggcc      420

acgcaccgcc gcgcgctgcc caaccacctg cacttccact cgctggagca cgaggaagcc      480

atgaatgcgg cctactcagg ctacgtctac acgcaccggc tcttccaccg cggtgaggac      540

gagccctact ccgagcccta tgccgactac ggcggcctcc aggagcacgt gtacgaggag      600

ataggggacg cgcccgagct ggacgcacgc gacggcctgc ggctctacga gcaggagcgc      660

gacgaggcgg ccgcgtaccg ccaggaggcc ctgggcgcgc ggctgcacca ttacgacgag      720

cgctccgacg gcgagtccga cagccccgag aaggaggccg agttcgcgcc ctacccgcgc      780

atggacagct acgagcagga ggaggacatc gaccagatag tggccgaggt gaagcagagc      840

atgagctcgc agagcctcga caaggcagcc gaggacatgc ctgaggccga gcaggacctg      900

gagcgtcccc ctaccccggc cgggggtcgc cccgacagcc ccgggctgca ggcgccggcg      960

gggcagcagc gggcggtggg ccccgcgggc ggcggcgagg cggggcagcg gtacagcaag     1020

gagaagcgcg atgccatctc gctggccatc aaggacatca aggaggccat cgaggaggtg     1080

aaaaccagga ccatccgttc gccttacacc cccgacgagc ccaaagagcc catctgggtc     1140

atgcgccagg acattagccc caccagggac tgtgacgacc agaggccgat ggacggagat     1200

tctccgtctc ctggcagctc ctcccccttg ggtgcagagt catcaagcac atctcttcac     1260

cccagtgacc ctgtggaagc gtccactaat aaagagtcaa gaaaaagctt ggcttcattc     1320

ccaacctacg ttgaagttcc gggaccctgc gaccccgaag acttgatcga tggaatcatt     1380

tttgccgcca attaccttgg ctccactcag ctgctctcag acaaaactcc ttccaaaaac     1440

gtgcgcatga tgcaggccca ggaagccgta agcaggatca agatggccca gaaattagcc     1500

aaaagcagga agaaggctcc tgaaggcgaa tctcagccaa tgactgaagt ggatctcttc     1560

atttctaccc agagaatcaa agtgctgaac gccgacacac aggagacaat gatggaccac     1620

cctctgagga ccatttccta cattgcggac attgggaaca tcgttgtgct gatggcccgc     1680

cggcggatgc ctcgctccaa ctcccaggag aacgtggaag cgtcccaccc atcccaggat     1740

gggaaaaggc agtacaagat gatctgccac gtcttcgagt ctgaggatgc tcagctgatt     1800

gcacagtcca tcggacaggc atttagcgtg gcataccagg aattcctcag ggccaatggg     1860

attaaccccg aagatctcag ccagaaggag tatagtgacc tgctcaatac ccaggacatg     1920

tacaacgatg acctgatcca cttctccaag tcggaaaact gtaaagatgt tttcatagag     1980

aagcagaaag gagaaatcct aggtgtggtg attgtggagt ctggctgggg atccatcctc     2040

cccaccgtga tcattgccaa catgatgcat ggtggccctg cggagaaatc tgggaagctg     2100

aatatcggtg accagatcat gtccattaat ggcaccagcc tggtgggcct gcctctgtcc     2160

acctgccaga gcattattaa gggcttaaag aatcagtccc gagtcaagct gaatatcgtg     2220

agatgtcctc cggtgaccac cgtgttaatc agaagaccag accttcgcta ccagctcggt     2280

ttcagcgtcc agaatggaat tatctgcagc ctcatgcgag ggggaatagc tgagagagga     2340

ggcgtccgtg tggggcaccg gatcattgaa atcaatggac agagcgtcgt ggccaccccc     2400

cacgagaaga tcgtccacat tctctccaat gctgttgggg agattcatat gaagacaatg     2460

ccagccgcga tgtacaggct gctgacggcc caggagcagc ctgtttacat ctga           2514


<210>  184
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Asn His Leu Glu Gly Ser Ala Glu Val Glu Val Thr Asp Glu Ala 
1               5                   10                  15      


Ala Gly Gly Glu Val Asn Glu Ser Val Glu Ala Asp Leu Glu His Pro 
            20                  25                  30          


Glu Val Glu Glu Glu Gln Gln Gln Pro Pro Gln Gln Gln His Tyr Val 
        35                  40                  45              


Gly Arg His Gln Arg Gly Arg Ala Leu Glu Asp Leu Arg Ala Gln Leu 
    50                  55                  60                  


Gly Gln Glu Glu Glu Glu Arg Gly Glu Cys Leu Ala Arg Ser Ala Ser 
65                  70                  75                  80  


Thr Glu Ser Gly Phe His Asn His Thr Asp Thr Ala Glu Gly Asp Val 
                85                  90                  95      


Ile Ala Ala Ala Arg Asp Gly Tyr Asp Ala Glu Arg Ala Gln Asp Pro 
            100                 105                 110         


Glu Asp Glu Ser Ala Tyr Ala Val Gln Tyr Arg Pro Glu Ala Glu Glu 
        115                 120                 125             


Tyr Thr Glu Gln Ala Glu Ala Glu His Ala Glu Ala Thr His Arg Arg 
    130                 135                 140                 


Ala Leu Pro Asn His Leu His Phe His Ser Leu Glu His Glu Glu Ala 
145                 150                 155                 160 


Met Asn Ala Ala Tyr Ser Gly Tyr Val Tyr Thr His Arg Leu Phe His 
                165                 170                 175     


Arg Gly Glu Asp Glu Pro Tyr Ser Glu Pro Tyr Ala Asp Tyr Gly Gly 
            180                 185                 190         


Leu Gln Glu His Val Tyr Glu Glu Ile Gly Asp Ala Pro Glu Leu Asp 
        195                 200                 205             


Ala Arg Asp Gly Leu Arg Leu Tyr Glu Gln Glu Arg Asp Glu Ala Ala 
    210                 215                 220                 


Ala Tyr Arg Gln Glu Ala Leu Gly Ala Arg Leu His His Tyr Asp Glu 
225                 230                 235                 240 


Arg Ser Asp Gly Glu Ser Asp Ser Pro Glu Lys Glu Ala Glu Phe Ala 
                245                 250                 255     


Pro Tyr Pro Arg Met Asp Ser Tyr Glu Gln Glu Glu Asp Ile Asp Gln 
            260                 265                 270         


Ile Val Ala Glu Val Lys Gln Ser Met Ser Ser Gln Ser Leu Asp Lys 
        275                 280                 285             


Ala Ala Glu Asp Met Pro Glu Ala Glu Gln Asp Leu Glu Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Gly Gly Arg Pro Asp Ser Pro Gly Leu Gln Ala Pro Ala 
305                 310                 315                 320 


Gly Gln Gln Arg Ala Val Gly Pro Ala Gly Gly Gly Glu Ala Gly Gln 
                325                 330                 335     


Arg Tyr Ser Lys Glu Lys Arg Asp Ala Ile Ser Leu Ala Ile Lys Asp 
            340                 345                 350         


Ile Lys Glu Ala Ile Glu Glu Val Lys Thr Arg Thr Ile Arg Ser Pro 
        355                 360                 365             


Tyr Thr Pro Asp Glu Pro Lys Glu Pro Ile Trp Val Met Arg Gln Asp 
    370                 375                 380                 


Ile Ser Pro Thr Arg Asp Cys Asp Asp Gln Arg Pro Met Asp Gly Asp 
385                 390                 395                 400 


Ser Pro Ser Pro Gly Ser Ser Ser Pro Leu Gly Ala Glu Ser Ser Ser 
                405                 410                 415     


Thr Ser Leu His Pro Ser Asp Pro Val Glu Ala Ser Thr Asn Lys Glu 
            420                 425                 430         


Ser Arg Lys Ser Leu Ala Ser Phe Pro Thr Tyr Val Glu Val Pro Gly 
        435                 440                 445             


Pro Cys Asp Pro Glu Asp Leu Ile Asp Gly Ile Ile Phe Ala Ala Asn 
    450                 455                 460                 


Tyr Leu Gly Ser Thr Gln Leu Leu Ser Asp Lys Thr Pro Ser Lys Asn 
465                 470                 475                 480 


Val Arg Met Met Gln Ala Gln Glu Ala Val Ser Arg Ile Lys Met Ala 
                485                 490                 495     


Gln Lys Leu Ala Lys Ser Arg Lys Lys Ala Pro Glu Gly Glu Ser Gln 
            500                 505                 510         


Pro Met Thr Glu Val Asp Leu Phe Ile Ser Thr Gln Arg Ile Lys Val 
        515                 520                 525             


Leu Asn Ala Asp Thr Gln Glu Thr Met Met Asp His Pro Leu Arg Thr 
    530                 535                 540                 


Ile Ser Tyr Ile Ala Asp Ile Gly Asn Ile Val Val Leu Met Ala Arg 
545                 550                 555                 560 


Arg Arg Met Pro Arg Ser Asn Ser Gln Glu Asn Val Glu Ala Ser His 
                565                 570                 575     


Pro Ser Gln Asp Gly Lys Arg Gln Tyr Lys Met Ile Cys His Val Phe 
            580                 585                 590         


Glu Ser Glu Asp Ala Gln Leu Ile Ala Gln Ser Ile Gly Gln Ala Phe 
        595                 600                 605             


Ser Val Ala Tyr Gln Glu Phe Leu Arg Ala Asn Gly Ile Asn Pro Glu 
    610                 615                 620                 


Asp Leu Ser Gln Lys Glu Tyr Ser Asp Leu Leu Asn Thr Gln Asp Met 
625                 630                 635                 640 


Tyr Asn Asp Asp Leu Ile His Phe Ser Lys Ser Glu Asn Cys Lys Asp 
                645                 650                 655     


Val Phe Ile Glu Lys Gln Lys Gly Glu Ile Leu Gly Val Val Ile Val 
            660                 665                 670         


Glu Ser Gly Trp Gly Ser Ile Leu Pro Thr Val Ile Ile Ala Asn Met 
        675                 680                 685             


Met His Gly Gly Pro Ala Glu Lys Ser Gly Lys Leu Asn Ile Gly Asp 
    690                 695                 700                 


Gln Ile Met Ser Ile Asn Gly Thr Ser Leu Val Gly Leu Pro Leu Ser 
705                 710                 715                 720 


Thr Cys Gln Ser Ile Ile Lys Gly Leu Lys Asn Gln Ser Arg Val Lys 
                725                 730                 735     


Leu Asn Ile Val Arg Cys Pro Pro Val Thr Thr Val Leu Ile Arg Arg 
            740                 745                 750         


Pro Asp Leu Arg Tyr Gln Leu Gly Phe Ser Val Gln Asn Gly Ile Ile 
        755                 760                 765             


Cys Ser Leu Met Arg Gly Gly Ile Ala Glu Arg Gly Gly Val Arg Val 
    770                 775                 780                 


Gly His Arg Ile Ile Glu Ile Asn Gly Gln Ser Val Val Ala Thr Pro 
785                 790                 795                 800 


His Glu Lys Ile Val His Ile Leu Ser Asn Ala Val Gly Glu Ile His 
                805                 810                 815     


Met Lys Thr Met Pro Ala Ala Met Tyr Arg Leu Leu Thr Ala Gln Glu 
            820                 825                 830         


Gln Pro Val Tyr Ile 
        835         


<210>  185
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  185
atgacccatt ggtttcatag gaacccatta aaagccacag ctcctgtgtc ttttaattac       60

tatggtgtag tcactggccc ttctgcttca aaaatatgca atgacttgag gtcatccagg      120

gcacgactcc ttgaactgtt cactgatttg agctgtaatc cagaaatgat gaagaatgca      180

gcagattcat atttctcact tttacaaggt ttcataaatt ctttggatga atctacccaa      240

gaaagcaagt tacgatatat tcaaaatttc aagtggactg atacattgca aggacaggtt      300

ccaagtgccc agcaggatgc tgtttttgaa ttaatttcca tgggatttaa tgtagcttta      360

tggtatacca aatatgcttc aagactggct ggaaaagaaa atataacaga agatgaagca      420

aaagaagttc atcgaagcct aaagattgca gctgggattt ttaaacattt aaaggaaagt      480

catctcccaa aactcattac acctgcggaa aaaggaagag atttagagtc acgactcata      540

gaagcatacg ttattcaatg tcaggctgaa gctcaagaag taacaattgc tcgagcaatt      600

gaactaaaac atgctcctgg actaattgct gcactggcgt atgaaacagc caatttctat      660

caaaaagctg atcatacttt atccagtttg gagcctgcat attctgccaa atggagaaaa      720

tatcttcact tgaagatgtg tttctacaca gcttatgctt actgttacca tggtgagact      780

ttattggcta gtgataaatg cggtgaagca atcaggtctc tccaagaagc agaaaaattg      840

tatgcaaagg cagaagcact gtgtaaagaa tatggagaaa ccaaaggacc tggaccaaca      900

gtcaaacctt caggacatct gttctttagg aaacttggaa accttgtgaa gaacacccta      960

gaaaaatgtc agagagaaaa tggatttatt tactttcaaa aaattccaac agaagcccca     1020

cagctggaac tcaaagcaaa ttatggtctc gtagagccta tacctttcga atttcctcct     1080

acaagtgttc agtggacacc agaaacattg gctgcatttg atctcaccaa aagacccaag     1140

gatgacagta ctaaacccaa accagaagaa gaagtgaaac ctgtgaaaga accagacatc     1200

aaacctcaaa aggacactgg gtgctacatc tcctaa                               1236


<210>  186
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Thr His Trp Phe His Arg Asn Pro Leu Lys Ala Thr Ala Pro Val 
1               5                   10                  15      


Ser Phe Asn Tyr Tyr Gly Val Val Thr Gly Pro Ser Ala Ser Lys Ile 
            20                  25                  30          


Cys Asn Asp Leu Arg Ser Ser Arg Ala Arg Leu Leu Glu Leu Phe Thr 
        35                  40                  45              


Asp Leu Ser Cys Asn Pro Glu Met Met Lys Asn Ala Ala Asp Ser Tyr 
    50                  55                  60                  


Phe Ser Leu Leu Gln Gly Phe Ile Asn Ser Leu Asp Glu Ser Thr Gln 
65                  70                  75                  80  


Glu Ser Lys Leu Arg Tyr Ile Gln Asn Phe Lys Trp Thr Asp Thr Leu 
                85                  90                  95      


Gln Gly Gln Val Pro Ser Ala Gln Gln Asp Ala Val Phe Glu Leu Ile 
            100                 105                 110         


Ser Met Gly Phe Asn Val Ala Leu Trp Tyr Thr Lys Tyr Ala Ser Arg 
        115                 120                 125             


Leu Ala Gly Lys Glu Asn Ile Thr Glu Asp Glu Ala Lys Glu Val His 
    130                 135                 140                 


Arg Ser Leu Lys Ile Ala Ala Gly Ile Phe Lys His Leu Lys Glu Ser 
145                 150                 155                 160 


His Leu Pro Lys Leu Ile Thr Pro Ala Glu Lys Gly Arg Asp Leu Glu 
                165                 170                 175     


Ser Arg Leu Ile Glu Ala Tyr Val Ile Gln Cys Gln Ala Glu Ala Gln 
            180                 185                 190         


Glu Val Thr Ile Ala Arg Ala Ile Glu Leu Lys His Ala Pro Gly Leu 
        195                 200                 205             


Ile Ala Ala Leu Ala Tyr Glu Thr Ala Asn Phe Tyr Gln Lys Ala Asp 
    210                 215                 220                 


His Thr Leu Ser Ser Leu Glu Pro Ala Tyr Ser Ala Lys Trp Arg Lys 
225                 230                 235                 240 


Tyr Leu His Leu Lys Met Cys Phe Tyr Thr Ala Tyr Ala Tyr Cys Tyr 
                245                 250                 255     


His Gly Glu Thr Leu Leu Ala Ser Asp Lys Cys Gly Glu Ala Ile Arg 
            260                 265                 270         


Ser Leu Gln Glu Ala Glu Lys Leu Tyr Ala Lys Ala Glu Ala Leu Cys 
        275                 280                 285             


Lys Glu Tyr Gly Glu Thr Lys Gly Pro Gly Pro Thr Val Lys Pro Ser 
    290                 295                 300                 


Gly His Leu Phe Phe Arg Lys Leu Gly Asn Leu Val Lys Asn Thr Leu 
305                 310                 315                 320 


Glu Lys Cys Gln Arg Glu Asn Gly Phe Ile Tyr Phe Gln Lys Ile Pro 
                325                 330                 335     


Thr Glu Ala Pro Gln Leu Glu Leu Lys Ala Asn Tyr Gly Leu Val Glu 
            340                 345                 350         


Pro Ile Pro Phe Glu Phe Pro Pro Thr Ser Val Gln Trp Thr Pro Glu 
        355                 360                 365             


Thr Leu Ala Ala Phe Asp Leu Thr Lys Arg Pro Lys Asp Asp Ser Thr 
    370                 375                 380                 


Lys Pro Lys Pro Glu Glu Glu Val Lys Pro Val Lys Glu Pro Asp Ile 
385                 390                 395                 400 


Lys Pro Gln Lys Asp Thr Gly Cys Tyr Ile Ser 
                405                 410     


<210>  187
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  187
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct       60

gcaggcgggg tcgctaaggc ctcaggagga gaaacacggg acatgccgtg gaagccgggg      120

cctcacagag tcttcgtaac ccaggaggaa gcccacggcg tcctgcaccg gcgccggcgc      180

gccaacgcgt tcctggagga gctgcggccg ggctccctgg agagggagtg caaggaggag      240

cagtgctcct tcgaggaggc ccgggagatc ttcaaggacg cggagaggac gaagctgttc      300

tggatttctt acagtgatgg ggaccagtgt gcctcaagtc catgccagaa tgggggctcc      360

tgcaaggacc agctccagtc ctatatctgc ttctgcctcc ctgccttcga gggccggaac      420

tgtgagacgc acaaggatga ccagctgatc tgtgtgaacg agaacggcgg ctgtgagcag      480

tactgcagtg accacacggg caccaagcgc tcctgtcggt gccacgaggg gtactctctg      540

ctggcagacg gggtgtcctg cacacccaca gttgaatatc catgtggaaa aatacctatt      600

ctagaaaaaa gaaatgccag caaaccccaa ggccgaattg tggggggcaa ggtgtgcccc      660

aaaggggagt gtccatggca ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg      720

accctgatca acaccatctg ggtggtctcc gcggcccact gtttcgacaa aatcaagaac      780

tggaggaacc tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag      840

cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac      900

cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc      960

ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg cttctcattg     1020

gtcagcggct ggggccagct gctggaccgt ggcgccacgg ccctggagct catggtcctc     1080

aacgtgcccc ggctgatgac ccaggactgc ctgcagcagt cacggaaggt gggagactcc     1140

ccaaatatca cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc     1200

aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc     1260

atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc     1320

tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc aggagtcctc     1380

ctgcgagccc catttcccta g                                               1401


<210>  188
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr 
            20                  25                  30          


Arg Asp Met Pro Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln 
        35                  40                  45              


Glu Glu Ala His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe 
    50                  55                  60                  


Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu 
65                  70                  75                  80  


Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg 
                85                  90                  95      


Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser 
            100                 105                 110         


Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr 
        115                 120                 125             


Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His 
    130                 135                 140                 


Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 
145                 150                 155                 160 


Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu 
                165                 170                 175     


Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu 
            180                 185                 190         


Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys 
        195                 200                 205             


Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys 
    210                 215                 220                 


Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly 
225                 230                 235                 240 


Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp 
                245                 250                 255     


Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp 
            260                 265                 270         


Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val 
        275                 280                 285             


Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala 
    290                 295                 300                 


Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro 
305                 310                 315                 320 


Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val 
                325                 330                 335     


Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala 
            340                 345                 350         


Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln 
        355                 360                 365             


Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr 
    370                 375                 380                 


Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys 
385                 390                 395                 400 


Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp 
                405                 410                 415     


Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly 
            420                 425                 430         


His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln 
        435                 440                 445             


Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro 
    450                 455                 460                 


Phe Pro 
465     


<210>  189
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  189
gacatcgaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt atcctttcac tttcggccct      300

gggaccaaag tggatatcaa ac                                               322


<210>  190
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  190

Asp Ile Glu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  191
<211>  2733
<212>  DNA
<213>  Homo sapiens

<400>  191
atgggtgtga gaggtttgca aggatttgtg ggaagtacct gcccacatat atgtacagta       60

gtaaatttca aagaactggc agagcaccac cgaagcaagt atcctggatg tacccctacc      120

attgtggttg atgccatgtg ttgtctcaga tattggtata ctccagaatc ttggatctgc      180

ggtggccagt ggcgagaata cttttctgct ttgcgagatt ttgttaaaac ttttacggca      240

gctgggatca agttgatatt cttctttgat ggcatggtgg agcaggataa gagagatgaa      300

tgggtgaaac gaaggctcaa gaacaacagg gagatatcca ggatttttca ttacatcaag      360

tcacacaagg agcagccagg cagaaatatg ttcttcatcc cctcagggct agctgtgttt      420

acacgatttg ctctaaagac actgggccag gaaactttgt gttctttgca ggaagcagat      480

tatgaggtag cttcctatgg cctccagcat aactgtcttg ggattctggg ggaagacact      540

gattacctaa tctatgacac ttgtccctac ttttcaatta gcgagctctg cctagagagc      600

ctggacaccg tcatgctctg cagagagaag ctctgtgaga gtctgggcct ctgtgtggcc      660

gaccttcctc ttctggcctg cctccttggc aacgacataa tcccagaggg catgtttgaa      720

agctttaggt acaaatgctt atcgtcctac acctctgtaa aagagaactt tgacaaaaaa      780

ggtaacatca tattagctgt gtcagaccat atatcgaaag ttctttactt gtatcaaggt      840

gagaaaaaat tagaagagat attacctctg ggaccaaaca aagctctttt ttataaagga      900

atggcatcat atcttttacc aggacaaaaa tctccatggt ttttccaaaa acccaaaggt      960

gtaataactt tggacaaaca agtaatatcc acgagttcag acgccgaatc cagggaagaa     1020

gttcccatgt gttcagatgc tgaatccagg caagaagttc ccatgtgtac aggccctgaa     1080

tccaggcgag aagttcccgt gtatacagat tctgaaccca ggcaagaagt tcccatgtgt     1140

tcagaccctg aacccaggca agaagttccc acgtgtacag gccctgaatc caggcgagaa     1200

gttcccatgt gttcagaccc tgaacccagg caagaagttc ccatgtgtac aggccctgaa     1260

gccaggcaag aagttcccat gtatacagac tctgaaccca ggcaagaagt tcccatgtat     1320

acagactctg aacccaggca agaagttccc atgtatacag gctctgaacc caggcaagaa     1380

gttcccatgt atacaggccc tgaatccagg caagaagttc ccatgtatac aggccctgaa     1440

tccaggcaag aagttttaat acggacagac cctgaatcta ggcaagaaat tatgtgtaca     1500

ggccatgaat ccaaacagga agttcccata tgtacagatc ctatatccaa gcaagaagac     1560

tccatgtgta cacacgctga aatcaatcaa aaattacctg tagcaacaga ttttgaattt     1620

aagctagaag ctctcatgtg tacaaaccct gaaattaaac aagaagaccc cacaaatgtg     1680

gggcctgaag taaagcaaca agtaaccatg gtttcagaca ctgaaatctt aaaggttgct     1740

agaacacatc acgtccaagc agaaagctac ctggtgtaca acatcatgag cagtggagag     1800

attgaatgca gcaacaccct agaagatgag cttgaccagg ccttacccag ccaggccttc     1860

atttaccgtc ccattcgaca gcgggtctac tcactcttac tggaggactg tcaagatgtc     1920

accagcacct gcctagctgt caaggagtgg tttgtgtatc ctgggaaccc actgaggcac     1980

ccggacctcg tcaggccgct gcagatgacc attccagggg gaacgcctag tttgaaaata     2040

ttatggctga accaagagcc agaaatacag gttcggcgct tggacacact cctagcctgt     2100

ttcaatcttt cctcctcaag agaagagctg caggctgtcg aaagcccatt tcaagctttg     2160

tgctgcctct tgatctacct ctttgtccag gtggacacgc tttgcctgga ggatttgcat     2220

gcgtttattg cgcaggcctt gtgcctccaa ggaaaatcca cctcgcagct tgtaaatcta     2280

cagcctgatt acatcaaccc cagagccgtg cagctgggct cccttctcgt ccgcggcctc     2340

accactctgg ttttagtcaa cagcgcatgt ggcttcccct ggaagacgag tgatttcatg     2400

ccctggaatg tatttgacgg gaagcttttt catcagaagt acttgcaatc tgaaaagggt     2460

tatgctgtgg aggttctttt agaacaaaat agatctcggc tcaccaaatt ccacaacctg     2520

aaggcagtcg tctgcaaggc ctgcatgaag gagaacagac gcatcactgg ccgagcccac     2580

tggggctcac accacgcagg gaggtgggga agacagggct ccagctacca caggacgggc     2640

tctgggtata gccgttccag tcagggacag ccgtggagag accagggacc aggaagcaga     2700

cagtatgagc atgaccagtg gagaaggtac tag                                  2733


<210>  192
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Gly Val Arg Gly Leu Gln Gly Phe Val Gly Ser Thr Cys Pro His 
1               5                   10                  15      


Ile Cys Thr Val Val Asn Phe Lys Glu Leu Ala Glu His His Arg Ser 
            20                  25                  30          


Lys Tyr Pro Gly Cys Thr Pro Thr Ile Val Val Asp Ala Met Cys Cys 
        35                  40                  45              


Leu Arg Tyr Trp Tyr Thr Pro Glu Ser Trp Ile Cys Gly Gly Gln Trp 
    50                  55                  60                  


Arg Glu Tyr Phe Ser Ala Leu Arg Asp Phe Val Lys Thr Phe Thr Ala 
65                  70                  75                  80  


Ala Gly Ile Lys Leu Ile Phe Phe Phe Asp Gly Met Val Glu Gln Asp 
                85                  90                  95      


Lys Arg Asp Glu Trp Val Lys Arg Arg Leu Lys Asn Asn Arg Glu Ile 
            100                 105                 110         


Ser Arg Ile Phe His Tyr Ile Lys Ser His Lys Glu Gln Pro Gly Arg 
        115                 120                 125             


Asn Met Phe Phe Ile Pro Ser Gly Leu Ala Val Phe Thr Arg Phe Ala 
    130                 135                 140                 


Leu Lys Thr Leu Gly Gln Glu Thr Leu Cys Ser Leu Gln Glu Ala Asp 
145                 150                 155                 160 


Tyr Glu Val Ala Ser Tyr Gly Leu Gln His Asn Cys Leu Gly Ile Leu 
                165                 170                 175     


Gly Glu Asp Thr Asp Tyr Leu Ile Tyr Asp Thr Cys Pro Tyr Phe Ser 
            180                 185                 190         


Ile Ser Glu Leu Cys Leu Glu Ser Leu Asp Thr Val Met Leu Cys Arg 
        195                 200                 205             


Glu Lys Leu Cys Glu Ser Leu Gly Leu Cys Val Ala Asp Leu Pro Leu 
    210                 215                 220                 


Leu Ala Cys Leu Leu Gly Asn Asp Ile Ile Pro Glu Gly Met Phe Glu 
225                 230                 235                 240 


Ser Phe Arg Tyr Lys Cys Leu Ser Ser Tyr Thr Ser Val Lys Glu Asn 
                245                 250                 255     


Phe Asp Lys Lys Gly Asn Ile Ile Leu Ala Val Ser Asp His Ile Ser 
            260                 265                 270         


Lys Val Leu Tyr Leu Tyr Gln Gly Glu Lys Lys Leu Glu Glu Ile Leu 
        275                 280                 285             


Pro Leu Gly Pro Asn Lys Ala Leu Phe Tyr Lys Gly Met Ala Ser Tyr 
    290                 295                 300                 


Leu Leu Pro Gly Gln Lys Ser Pro Trp Phe Phe Gln Lys Pro Lys Gly 
305                 310                 315                 320 


Val Ile Thr Leu Asp Lys Gln Val Ile Ser Thr Ser Ser Asp Ala Glu 
                325                 330                 335     


Ser Arg Glu Glu Val Pro Met Cys Ser Asp Ala Glu Ser Arg Gln Glu 
            340                 345                 350         


Val Pro Met Cys Thr Gly Pro Glu Ser Arg Arg Glu Val Pro Val Tyr 
        355                 360                 365             


Thr Asp Ser Glu Pro Arg Gln Glu Val Pro Met Cys Ser Asp Pro Glu 
    370                 375                 380                 


Pro Arg Gln Glu Val Pro Thr Cys Thr Gly Pro Glu Ser Arg Arg Glu 
385                 390                 395                 400 


Val Pro Met Cys Ser Asp Pro Glu Pro Arg Gln Glu Val Pro Met Cys 
                405                 410                 415     


Thr Gly Pro Glu Ala Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu 
            420                 425                 430         


Pro Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu Pro Arg Gln Glu 
        435                 440                 445             


Val Pro Met Tyr Thr Gly Ser Glu Pro Arg Gln Glu Val Pro Met Tyr 
    450                 455                 460                 


Thr Gly Pro Glu Ser Arg Gln Glu Val Pro Met Tyr Thr Gly Pro Glu 
465                 470                 475                 480 


Ser Arg Gln Glu Val Leu Ile Arg Thr Asp Pro Glu Ser Arg Gln Glu 
                485                 490                 495     


Ile Met Cys Thr Gly His Glu Ser Lys Gln Glu Val Pro Ile Cys Thr 
            500                 505                 510         


Asp Pro Ile Ser Lys Gln Glu Asp Ser Met Cys Thr His Ala Glu Ile 
        515                 520                 525             


Asn Gln Lys Leu Pro Val Ala Thr Asp Phe Glu Phe Lys Leu Glu Ala 
    530                 535                 540                 


Leu Met Cys Thr Asn Pro Glu Ile Lys Gln Glu Asp Pro Thr Asn Val 
545                 550                 555                 560 


Gly Pro Glu Val Lys Gln Gln Val Thr Met Val Ser Asp Thr Glu Ile 
                565                 570                 575     


Leu Lys Val Ala Arg Thr His His Val Gln Ala Glu Ser Tyr Leu Val 
            580                 585                 590         


Tyr Asn Ile Met Ser Ser Gly Glu Ile Glu Cys Ser Asn Thr Leu Glu 
        595                 600                 605             


Asp Glu Leu Asp Gln Ala Leu Pro Ser Gln Ala Phe Ile Tyr Arg Pro 
    610                 615                 620                 


Ile Arg Gln Arg Val Tyr Ser Leu Leu Leu Glu Asp Cys Gln Asp Val 
625                 630                 635                 640 


Thr Ser Thr Cys Leu Ala Val Lys Glu Trp Phe Val Tyr Pro Gly Asn 
                645                 650                 655     


Pro Leu Arg His Pro Asp Leu Val Arg Pro Leu Gln Met Thr Ile Pro 
            660                 665                 670         


Gly Gly Thr Pro Ser Leu Lys Ile Leu Trp Leu Asn Gln Glu Pro Glu 
        675                 680                 685             


Ile Gln Val Arg Arg Leu Asp Thr Leu Leu Ala Cys Phe Asn Leu Ser 
    690                 695                 700                 


Ser Ser Arg Glu Glu Leu Gln Ala Val Glu Ser Pro Phe Gln Ala Leu 
705                 710                 715                 720 


Cys Cys Leu Leu Ile Tyr Leu Phe Val Gln Val Asp Thr Leu Cys Leu 
                725                 730                 735     


Glu Asp Leu His Ala Phe Ile Ala Gln Ala Leu Cys Leu Gln Gly Lys 
            740                 745                 750         


Ser Thr Ser Gln Leu Val Asn Leu Gln Pro Asp Tyr Ile Asn Pro Arg 
        755                 760                 765             


Ala Val Gln Leu Gly Ser Leu Leu Val Arg Gly Leu Thr Thr Leu Val 
    770                 775                 780                 


Leu Val Asn Ser Ala Cys Gly Phe Pro Trp Lys Thr Ser Asp Phe Met 
785                 790                 795                 800 


Pro Trp Asn Val Phe Asp Gly Lys Leu Phe His Gln Lys Tyr Leu Gln 
                805                 810                 815     


Ser Glu Lys Gly Tyr Ala Val Glu Val Leu Leu Glu Gln Asn Arg Ser 
            820                 825                 830         


Arg Leu Thr Lys Phe His Asn Leu Lys Ala Val Val Cys Lys Ala Cys 
        835                 840                 845             


Met Lys Glu Asn Arg Arg Ile Thr Gly Arg Ala His Trp Gly Ser His 
    850                 855                 860                 


His Ala Gly Arg Trp Gly Arg Gln Gly Ser Ser Tyr His Arg Thr Gly 
865                 870                 875                 880 


Ser Gly Tyr Ser Arg Ser Ser Gln Gly Gln Pro Trp Arg Asp Gln Gly 
                885                 890                 895     


Pro Gly Ser Arg Gln Tyr Glu His Asp Gln Trp Arg Arg Tyr 
            900                 905                 910 


<210>  193
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  193
atggcggaag ttcatagacg tcagcatgct cgggttaaag gagaagcccc cgcgaaatcc       60

tccacactcc gagatgagga ggagctgggg atggcgtcgg ccgaaacgct gaccgtgttt      120

ctgaagctgc tggccgccgg cttttacggc gtgagctcct tcctgatcgt ggtggtgaat      180

aagagcgtgc tcaccaatta cagatttccc tcctcactat gtgttggact tggccagatg      240

gtggccacag tggcagttct ctgggtggga aaggcgctca gagtagtcaa gtttcctgac      300

cttgacagaa atgtacctcg aaagacgttt ccactacctc tactatattt tgggaaccaa      360

atcacgggac tgttcagcac aaagaaactg aacttgccaa tgtttacagt tctgagaagg      420

ttctccatcc tgtttacaat gtttgctgaa ggagttttac tcaagaagac tttttcttgg      480

ggtattaaaa tgactgtatt tgcaatgatt attggagcct ttgtagctgc cagctctgac      540

ttggcatttg atctggaagg atatgctttt attctgataa acgatgtcct aacagcagca      600

aatggtgcat acgtaaaaca aaaattagat tcaaaagagc tgggaaaata tggactgctc      660

tattacaatg cactgttcat gattctgccc accctggcca ttgcgtattt cacaggagat      720

gcacaaaagg ctgtggagtt tgaaggctgg gctgacaccc tctttcttct gcagttcacc      780

ctctcctgtg tgatggggtt tatcttaatg tacgccacag tactctgcac gcagtataat      840

tctgctctta caactacaat agttggctgt attaagaata tattaataac ttatattgga      900

atggtctttg gtggagatta tattttcacg tggacaaact tcattggttt aaatatcagc      960

attgctggga gcctggtata ttcctatatc actttcactg aagagcagct gagcaaacag     1020

tcagaggcta ataacaagct ggacattaag gggaaaggag cagtgtga                  1068


<210>  194
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Glu Val His Arg Arg Gln His Ala Arg Val Lys Gly Glu Ala 
1               5                   10                  15      


Pro Ala Lys Ser Ser Thr Leu Arg Asp Glu Glu Glu Leu Gly Met Ala 
            20                  25                  30          


Ser Ala Glu Thr Leu Thr Val Phe Leu Lys Leu Leu Ala Ala Gly Phe 
        35                  40                  45              


Tyr Gly Val Ser Ser Phe Leu Ile Val Val Val Asn Lys Ser Val Leu 
    50                  55                  60                  


Thr Asn Tyr Arg Phe Pro Ser Ser Leu Cys Val Gly Leu Gly Gln Met 
65                  70                  75                  80  


Val Ala Thr Val Ala Val Leu Trp Val Gly Lys Ala Leu Arg Val Val 
                85                  90                  95      


Lys Phe Pro Asp Leu Asp Arg Asn Val Pro Arg Lys Thr Phe Pro Leu 
            100                 105                 110         


Pro Leu Leu Tyr Phe Gly Asn Gln Ile Thr Gly Leu Phe Ser Thr Lys 
        115                 120                 125             


Lys Leu Asn Leu Pro Met Phe Thr Val Leu Arg Arg Phe Ser Ile Leu 
    130                 135                 140                 


Phe Thr Met Phe Ala Glu Gly Val Leu Leu Lys Lys Thr Phe Ser Trp 
145                 150                 155                 160 


Gly Ile Lys Met Thr Val Phe Ala Met Ile Ile Gly Ala Phe Val Ala 
                165                 170                 175     


Ala Ser Ser Asp Leu Ala Phe Asp Leu Glu Gly Tyr Ala Phe Ile Leu 
            180                 185                 190         


Ile Asn Asp Val Leu Thr Ala Ala Asn Gly Ala Tyr Val Lys Gln Lys 
        195                 200                 205             


Leu Asp Ser Lys Glu Leu Gly Lys Tyr Gly Leu Leu Tyr Tyr Asn Ala 
    210                 215                 220                 


Leu Phe Met Ile Leu Pro Thr Leu Ala Ile Ala Tyr Phe Thr Gly Asp 
225                 230                 235                 240 


Ala Gln Lys Ala Val Glu Phe Glu Gly Trp Ala Asp Thr Leu Phe Leu 
                245                 250                 255     


Leu Gln Phe Thr Leu Ser Cys Val Met Gly Phe Ile Leu Met Tyr Ala 
            260                 265                 270         


Thr Val Leu Cys Thr Gln Tyr Asn Ser Ala Leu Thr Thr Thr Ile Val 
        275                 280                 285             


Gly Cys Ile Lys Asn Ile Leu Ile Thr Tyr Ile Gly Met Val Phe Gly 
    290                 295                 300                 


Gly Asp Tyr Ile Phe Thr Trp Thr Asn Phe Ile Gly Leu Asn Ile Ser 
305                 310                 315                 320 


Ile Ala Gly Ser Leu Val Tyr Ser Tyr Ile Thr Phe Thr Glu Glu Gln 
                325                 330                 335     


Leu Ser Lys Gln Ser Glu Ala Asn Asn Lys Leu Asp Ile Lys Gly Lys 
            340                 345                 350         


Gly Ala Val 
        355 


<210>  195
<211>  2760
<212>  DNA
<213>  Homo sapiens

<400>  195
atgacggctg aagaaacagt gaatgtaaaa gaggttgaaa tcattaagct aattttggac       60

ttcctgaatt caaagaagct tcacattagt atgctggccc tggagaagga aagtggagtc      120

ataaatggcc tgttttcaga tgatatgctt ttcctgaggc agctaatact tgatggtcaa      180

tgggatgaag ttcttcagtt cattcagcct ctagaatgta tggaaaaatt tgacaaaaaa      240

aggtttcgtt atattatcct gaagcagaag tttttagaag ctttatgtgt taacaacgcg      300

atgtcagcag aagatgagcc ccagcatctg gaatttacca tgcaagaagc tgtgcaatgt      360

ttacatgctc tagaagaata ctgtccttct aaagatgact atagtaagct ctgtttgctt      420

ttgactttgc ctcgtctgac caatcatgcc gagtttaagg actggaatcc cagcaccgca      480

cgagttcact gttttgaaga ggcttgtgtc atggttgcag aattcatccc tgctgatagg      540

aagctaagtg aagctggttt taaggctagt aacaatcgtt tatttcagct tgtaatgaaa      600

ggcctgcttt atgaatgctg tgtagaattt tgtcagagta aagcaactgg agaagaaatt      660

acagaaagcg aagtgcttct tggcatcgac ctcttatgtg gtaatggttg tgatgatttg      720

gatctgagtt tactgtcatg gcttcagaat cttccatctt ctgtcttctc ttgtgctttt      780

gaacagaaaa tgcttaatat tcatgttgac aaacttctga aacctacaaa agctgcatat      840

gctgatcttt tgactcctct tatcagcaaa ctctctccct atccatcatc cccaatgaga      900

agacctcaat cagctgatgc ctatatgacc cgctctctga atcctgcttt agatggcctc      960

acctgtggac taaccagtca tgataagaga atttcagacc ttggaaacaa aacttctcca     1020

atgtcacact cctttgctaa cttccattat ccaggggtac aaaacctcag tagaagtctc     1080

atgcttgaga atacagaatg tcacagtatt tacgaagaat cccctgagcg tgatacacct     1140

gttgatgcac agaggcctat cggcagtgaa atcttgggcc agagttcagt ttcagaaaaa     1200

gagcctgcaa atggagcaca gaatccagga ccagctaaac aagaaaaaaa tgagcttcga     1260

gattcaacag aacaatttca agaatattat aggcaaagat tacgctatca acagcattta     1320

gaacagaagg agcaacagcg gcagatatac caacagatgt tgcttgaagg aggcgtgaat     1380

caggaggatg gtcctgatca gcagcagaat cttactgaac agttccttaa taggtccatt     1440

caaaagcttg gtgaattaaa tattggaatg gatggccttg gtaatgaggt atcagcactc     1500

aaccagcaat gtaatgggag caaaggcaat ggatctaatg gttcttctgt gactagtttt     1560

actacaccac cccaagactc tagtcagaga ttaacacatg atgcttcaaa tattcataca     1620

agcactcctc gtaatcctgg atcaacaaat cacatacctt ttctggagga atcaccttgt     1680

ggaagccaaa tctcttcaga acattcggtc attaagccac ctcttggaga ttctccaggg     1740

agtctttcaa ggtcgaaagg ggaagaggat gacaaatcaa aaaagcagtt tgtttgtatt     1800

aatatcctag aagacacaca agctgttaga gcagtggctt ttcatccagc tggaggttta     1860

tatgctgttg gttcaaattc aaaaactctg agagtatgtg cctatccaga tgtaattgat     1920

ccaagtgcac atgagactcc taagcagccg gtggtacgtt ttaaaaggaa taaacatcat     1980

aaaggatcca tttactgtgt ggcctggagt ccttgtgggc agttattagc aacaggatca     2040

aatgacaaat acgtcaaagt gctgcccttc aatgcagaga cttgtaacgc aacaggacca     2100

gatctggaat ttagtatgca tgatggaaca attagagact tggcatttat ggaaggccca     2160

gaaagcggag gagctatttt aataagtgct ggagcagggg attgtaacat ttatacaacc     2220

gattgtcaaa gaggacaggg cctccatgct ttgagtggac atactgggca tattttagca     2280

ctttatacct ggagtggctg gatgattgca tctggttccc aagataagac tgttagattt     2340

tgggatcttc gagtaccaag ttgtgttcgt gttgttggca caacatttca tggaactggc     2400

agtgcagtgg catctgtagc tgtagatccc agtggtcgtc tcttagccac aggtcaagaa     2460

gattctagct gcatgttgta tgacataaga ggaggaagaa tggtacaaag ttatcatcct     2520

cattccagtg atgttcgctc tgttcgattc tcccctggag ctcactactt gctaacaggc     2580

tcttatgata tgaaaataaa ggtgacagac ctacaagggg acctcaccaa gcagcttcct     2640

atcatggtgg tgggggagca caaggacaaa gtgattcagt gcagatggca cacccaggat     2700

ctttccttcc tgtcatcctc tgcagataga actgtcaccc tctggactta caatgggtag     2760


<210>  196
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Thr Ala Glu Glu Thr Val Asn Val Lys Glu Val Glu Ile Ile Lys 
1               5                   10                  15      


Leu Ile Leu Asp Phe Leu Asn Ser Lys Lys Leu His Ile Ser Met Leu 
            20                  25                  30          


Ala Leu Glu Lys Glu Ser Gly Val Ile Asn Gly Leu Phe Ser Asp Asp 
        35                  40                  45              


Met Leu Phe Leu Arg Gln Leu Ile Leu Asp Gly Gln Trp Asp Glu Val 
    50                  55                  60                  


Leu Gln Phe Ile Gln Pro Leu Glu Cys Met Glu Lys Phe Asp Lys Lys 
65                  70                  75                  80  


Arg Phe Arg Tyr Ile Ile Leu Lys Gln Lys Phe Leu Glu Ala Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Met Ser Ala Glu Asp Glu Pro Gln His Leu Glu Phe 
            100                 105                 110         


Thr Met Gln Glu Ala Val Gln Cys Leu His Ala Leu Glu Glu Tyr Cys 
        115                 120                 125             


Pro Ser Lys Asp Asp Tyr Ser Lys Leu Cys Leu Leu Leu Thr Leu Pro 
    130                 135                 140                 


Arg Leu Thr Asn His Ala Glu Phe Lys Asp Trp Asn Pro Ser Thr Ala 
145                 150                 155                 160 


Arg Val His Cys Phe Glu Glu Ala Cys Val Met Val Ala Glu Phe Ile 
                165                 170                 175     


Pro Ala Asp Arg Lys Leu Ser Glu Ala Gly Phe Lys Ala Ser Asn Asn 
            180                 185                 190         


Arg Leu Phe Gln Leu Val Met Lys Gly Leu Leu Tyr Glu Cys Cys Val 
        195                 200                 205             


Glu Phe Cys Gln Ser Lys Ala Thr Gly Glu Glu Ile Thr Glu Ser Glu 
    210                 215                 220                 


Val Leu Leu Gly Ile Asp Leu Leu Cys Gly Asn Gly Cys Asp Asp Leu 
225                 230                 235                 240 


Asp Leu Ser Leu Leu Ser Trp Leu Gln Asn Leu Pro Ser Ser Val Phe 
                245                 250                 255     


Ser Cys Ala Phe Glu Gln Lys Met Leu Asn Ile His Val Asp Lys Leu 
            260                 265                 270         


Leu Lys Pro Thr Lys Ala Ala Tyr Ala Asp Leu Leu Thr Pro Leu Ile 
        275                 280                 285             


Ser Lys Leu Ser Pro Tyr Pro Ser Ser Pro Met Arg Arg Pro Gln Ser 
    290                 295                 300                 


Ala Asp Ala Tyr Met Thr Arg Ser Leu Asn Pro Ala Leu Asp Gly Leu 
305                 310                 315                 320 


Thr Cys Gly Leu Thr Ser His Asp Lys Arg Ile Ser Asp Leu Gly Asn 
                325                 330                 335     


Lys Thr Ser Pro Met Ser His Ser Phe Ala Asn Phe His Tyr Pro Gly 
            340                 345                 350         


Val Gln Asn Leu Ser Arg Ser Leu Met Leu Glu Asn Thr Glu Cys His 
        355                 360                 365             


Ser Ile Tyr Glu Glu Ser Pro Glu Arg Asp Thr Pro Val Asp Ala Gln 
    370                 375                 380                 


Arg Pro Ile Gly Ser Glu Ile Leu Gly Gln Ser Ser Val Ser Glu Lys 
385                 390                 395                 400 


Glu Pro Ala Asn Gly Ala Gln Asn Pro Gly Pro Ala Lys Gln Glu Lys 
                405                 410                 415     


Asn Glu Leu Arg Asp Ser Thr Glu Gln Phe Gln Glu Tyr Tyr Arg Gln 
            420                 425                 430         


Arg Leu Arg Tyr Gln Gln His Leu Glu Gln Lys Glu Gln Gln Arg Gln 
        435                 440                 445             


Ile Tyr Gln Gln Met Leu Leu Glu Gly Gly Val Asn Gln Glu Asp Gly 
    450                 455                 460                 


Pro Asp Gln Gln Gln Asn Leu Thr Glu Gln Phe Leu Asn Arg Ser Ile 
465                 470                 475                 480 


Gln Lys Leu Gly Glu Leu Asn Ile Gly Met Asp Gly Leu Gly Asn Glu 
                485                 490                 495     


Val Ser Ala Leu Asn Gln Gln Cys Asn Gly Ser Lys Gly Asn Gly Ser 
            500                 505                 510         


Asn Gly Ser Ser Val Thr Ser Phe Thr Thr Pro Pro Gln Asp Ser Ser 
        515                 520                 525             


Gln Arg Leu Thr His Asp Ala Ser Asn Ile His Thr Ser Thr Pro Arg 
    530                 535                 540                 


Asn Pro Gly Ser Thr Asn His Ile Pro Phe Leu Glu Glu Ser Pro Cys 
545                 550                 555                 560 


Gly Ser Gln Ile Ser Ser Glu His Ser Val Ile Lys Pro Pro Leu Gly 
                565                 570                 575     


Asp Ser Pro Gly Ser Leu Ser Arg Ser Lys Gly Glu Glu Asp Asp Lys 
            580                 585                 590         


Ser Lys Lys Gln Phe Val Cys Ile Asn Ile Leu Glu Asp Thr Gln Ala 
        595                 600                 605             


Val Arg Ala Val Ala Phe His Pro Ala Gly Gly Leu Tyr Ala Val Gly 
    610                 615                 620                 


Ser Asn Ser Lys Thr Leu Arg Val Cys Ala Tyr Pro Asp Val Ile Asp 
625                 630                 635                 640 


Pro Ser Ala His Glu Thr Pro Lys Gln Pro Val Val Arg Phe Lys Arg 
                645                 650                 655     


Asn Lys His His Lys Gly Ser Ile Tyr Cys Val Ala Trp Ser Pro Cys 
            660                 665                 670         


Gly Gln Leu Leu Ala Thr Gly Ser Asn Asp Lys Tyr Val Lys Val Leu 
        675                 680                 685             


Pro Phe Asn Ala Glu Thr Cys Asn Ala Thr Gly Pro Asp Leu Glu Phe 
    690                 695                 700                 


Ser Met His Asp Gly Thr Ile Arg Asp Leu Ala Phe Met Glu Gly Pro 
705                 710                 715                 720 


Glu Ser Gly Gly Ala Ile Leu Ile Ser Ala Gly Ala Gly Asp Cys Asn 
                725                 730                 735     


Ile Tyr Thr Thr Asp Cys Gln Arg Gly Gln Gly Leu His Ala Leu Ser 
            740                 745                 750         


Gly His Thr Gly His Ile Leu Ala Leu Tyr Thr Trp Ser Gly Trp Met 
        755                 760                 765             


Ile Ala Ser Gly Ser Gln Asp Lys Thr Val Arg Phe Trp Asp Leu Arg 
    770                 775                 780                 


Val Pro Ser Cys Val Arg Val Val Gly Thr Thr Phe His Gly Thr Gly 
785                 790                 795                 800 


Ser Ala Val Ala Ser Val Ala Val Asp Pro Ser Gly Arg Leu Leu Ala 
                805                 810                 815     


Thr Gly Gln Glu Asp Ser Ser Cys Met Leu Tyr Asp Ile Arg Gly Gly 
            820                 825                 830         


Arg Met Val Gln Ser Tyr His Pro His Ser Ser Asp Val Arg Ser Val 
        835                 840                 845             


Arg Phe Ser Pro Gly Ala His Tyr Leu Leu Thr Gly Ser Tyr Asp Met 
    850                 855                 860                 


Lys Ile Lys Val Thr Asp Leu Gln Gly Asp Leu Thr Lys Gln Leu Pro 
865                 870                 875                 880 


Ile Met Val Val Gly Glu His Lys Asp Lys Val Ile Gln Cys Arg Trp 
                885                 890                 895     


His Thr Gln Asp Leu Ser Phe Leu Ser Ser Ser Ala Asp Arg Thr Val 
            900                 905                 910         


Thr Leu Trp Thr Tyr Asn Gly 
        915                 


<210>  197
<211>  3537
<212>  DNA
<213>  Homo sapiens

<400>  197
atgctgaagt tccgaacagt ccatgggggc ctgaggctcc tgggaatccg ccgaacctcc       60

accgcccccg ctgcctcccc aaatgtccgg cgcctggagt ataagcccat caagaaagtc      120

atggtggcca acagaggtga gattgccatc cgtgtgttcc gggcctgcac ggagctgggc      180

atccgcaccg tagccatcta ctctgagcag gacacgggcc agatgcaccg gcagaaagca      240

gatgaagcct atctcatcgg ccgcggcctg gcccccgtgc aggcctacct gcacatccca      300

gacatcatca aggtggccaa ggagaacaac gtagatgcag tgcaccctgg ctacgggttc      360

ctctctgagc gagcggactt cgcccaggcc tgccaggatg caggggtccg gtttattggg      420

ccaagcccag aagtggtccg caagatggga gacaaggtgg aggcccgggc catcgccatt      480

gctgcgggtg ttcccgttgt ccctggcaca gatgccccca tcacgtccct gcatgaggcc      540

cacgagttct ccaacaccta cggcttcccc atcatcttca aggcggccta tgggggtgga      600

gggcgtggca tgagggtggt gcacagctac gaggagctgg aggagaatta cacccgggcc      660

tactcagagg ctctggccgc ctttgggaat ggggcgctgt ttgtggagaa gttcatcgag      720

aagccacggc acatcgaggt gcagatcttg ggggaccagt atgggaacat cctgcacctg      780

tacgagcgag actgctccat ccagcggcgg caccagaagg tggtcgagat tgcccccgcc      840

gcccacctgg acccgcagct tcggactcgg ctcaccagcg actctgtgaa actcgctaaa      900

caggtgggct acgagaacgc aggcaccgtg gagttcctgg tggacaggca cggcaagcac      960

tacttcatcg aggtcaactc ccgcctgcag gtggagcaca cggtcacaga ggagatcacc     1020

gacgtagacc tggtccatgc tcagatccac gtggctgagg gcaggagcct acccgacctg     1080

ggcctgcggc aggagaacat ccgcatcaac gggtgtgcca tccagtgccg ggtcaccacc     1140

gaggaccccg cgcgcagctt ccagccggac accggccgca ttgaggtgtt ccggagcgga     1200

gagggcatgg gcatccgcct ggataatgct tccgccttcc aaggagccgt catctcgccc     1260

cactacgact ccctgctggt caaagtcatt gcccacggca aagaccaccc cacggccgcc     1320

accaagatga gcagggccct tgcggagttc cgcgtccgag gtgtgaagac caacatcgcc     1380

ttcctgcaga atgtgctcaa caaccagcag ttcctggcag gcactgtgga cacccagttc     1440

atcgacgaga acccagagct gttccagctg cggcctgcac agaaccgggc ccaaaagctg     1500

ttgcactacc tcggccatgt catggtaaac ggtccaacca ccccgattcc cgtcaaggcc     1560

agccccagcc ccacggaccc cgttgtccct gcagtgccca taggcccgcc cccggctggt     1620

ttcagagaca tcctgctgcg agaggggcct gagggctttg ctcgagctgt gcggaaccac     1680

ccggggctgc tgctgatgga cacgaccttc agggacgccc accagtcact gctggccact     1740

cgtgtgcgca cccacgatct caaaaagatc gccccctatg ttgcccacaa cttcagcaag     1800

ctcttcagca tggagaactg gggaggagcc acgtttgacg tcgccatgcg cttcctgtat     1860

gagtgcccct ggcggcggct gcaggagctc cgggagctca tccccaacat ccctttccag     1920

atgctgctgc ggggggccaa tgctgtgggc tacaccaact acccagacaa cgtggtcttc     1980

aagttctgtg aagtggccaa agagaatggc atggatgtct tccgtgtgtt tgactccctc     2040

aactacttgc ccaacatgct gctgggcatg gaggcggcag gaagtgccgg aggcgtggtg     2100

gaggctgcca tctcatacac gggcgacgtg gccgacccca gccgcaccaa gtactcactg     2160

cagtactaca tgggcttggc cgaagagctg gtgcgagctg gcacccacat cctgtgcatc     2220

aaggacatgg ccgggctgct gaagcccacg gcctgcacca tgctggtcag ctccctccgg     2280

gaccgcttcc ccgacctccc actgcacatc cacacccacg acacgtcagg ggcaggcgtg     2340

gcagccatgc tggcctgtgc ccaggctgga gctgatgtgg tggatgtggc agctgattcc     2400

atgtctggga tgacttcaca gcccagcatg ggggccctgg tggcctgtac cagagggact     2460

cccctggaca cagaggtgcc catggagcgc gtgtttgact acagtgagta ctgggagggg     2520

gctcggggac tgtacgcggc cttcgactgc acggccacca tgaagtctgg caactcggac     2580

gtgtatgaaa atgagatccc agggggccag tacaccaacc tgcacttcca ggcccacagc     2640

atggggcttg gctccaagtt caaggaggtc aagaaggcct atgtggaggc caaccagatg     2700

ctgggcgatc tcatcaaggt gacgccctcc tccaagatcg tgggggacct ggcccagttt     2760

atggtgcaga atggattgag ccgggcagag gccgaagctc aggcggaaga gctgtccttt     2820

ccccgctccg tggtggagtt cctgcagggc tacatcggtg tcccccatgg ggggttcccc     2880

gaaccctttc gctctaaggt actgaaggac ctgccaaggg tggaggggcg gcctggagcc     2940

tccctccctc ccctggatct gcaggcactg gagaaggagc tggtagaccg gcatggggag     3000

gaggtgacgc cggaagatgt gctctcagca gctatgtacc ccgatgtgtt tgcccacttc     3060

aaggacttca ctgccacctt tggccccctg gatagcctga atactcgcct cttcctgcag     3120

ggacccaaga tcgcagagga gtttgaggtg gagctggagc ggggcaagac gctgcacatc     3180

aaagccctgg ccgtgagcga cctgaaccgg gccggccaga ggcaggtctt ctttgagctc     3240

aatgggcagc tgcggtccat cttggtcaag gacacccagg ccatgaagga gatgcacttc     3300

caccccaagg ccctaaagga cgtgaagggc cagatcgggg cgcccatgcc tgggaaggtg     3360

atagacatca aagtggtggc aggggccaag gtggccaagg gccagcccct gtgtgtgctc     3420

agtgccatga agatggagac tgtggtgacc tcacccatgg agggtactgt ccgcaaggtt     3480

catgtgacca aggacatgac actggaaggt gacgacctca tcctggagat cgagtga        3537


<210>  198
<211>  1178
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
            20                  25                  30          


Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
        35                  40                  45              


Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
    50                  55                  60                  


Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
65                  70                  75                  80  


Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                85                  90                  95      


Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
        115                 120                 125             


Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
    130                 135                 140                 


Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
145                 150                 155                 160 


Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                165                 170                 175     


Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
            180                 185                 190         


Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
        195                 200                 205             


Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
    210                 215                 220                 


Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
225                 230                 235                 240 


Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                245                 250                 255     


Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
            260                 265                 270         


Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
        275                 280                 285             


Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
    290                 295                 300                 


Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
305                 310                 315                 320 


Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                325                 330                 335     


Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
            340                 345                 350         


Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
        355                 360                 365             


Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
    370                 375                 380                 


Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
385                 390                 395                 400 


Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                405                 410                 415     


Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
            420                 425                 430         


Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
        435                 440                 445             


Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
    450                 455                 460                 


Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
465                 470                 475                 480 


Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                485                 490                 495     


Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
            500                 505                 510         


Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
        515                 520                 525             


Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
    530                 535                 540                 


Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
545                 550                 555                 560 


Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                565                 570                 575     


Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
            580                 585                 590         


Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
        595                 600                 605             


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
    610                 615                 620                 


Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
625                 630                 635                 640 


Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                645                 650                 655     


Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
            660                 665                 670         


Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
        675                 680                 685             


Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
    690                 695                 700                 


Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
705                 710                 715                 720 


Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                725                 730                 735     


Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
            740                 745                 750         


Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
        755                 760                 765             


His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
    770                 775                 780                 


Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
785                 790                 795                 800 


Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                805                 810                 815     


Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
            820                 825                 830         


Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
        835                 840                 845             


Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
    850                 855                 860                 


Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
865                 870                 875                 880 


Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                885                 890                 895     


Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
            900                 905                 910         


Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
        915                 920                 925             


Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
    930                 935                 940                 


Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
945                 950                 955                 960 


Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                965                 970                 975     


Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
            980                 985                 990         


Glu Leu Val Asp Arg His Gly Glu  Glu Val Thr Pro Glu  Asp Val Leu 
        995                 1000                 1005             


Ser Ala  Ala Met Tyr Pro Asp  Val Phe Ala His Phe  Lys Asp Phe 
    1010                 1015                 1020             


Thr Ala  Thr Phe Gly Pro Leu  Asp Ser Leu Asn Thr  Arg Leu Phe 
    1025                 1030                 1035             


Leu Gln  Gly Pro Lys Ile Ala  Glu Glu Phe Glu Val  Glu Leu Glu 
    1040                 1045                 1050             


Arg Gly  Lys Thr Leu His Ile  Lys Ala Leu Ala Val  Ser Asp Leu 
    1055                 1060                 1065             


Asn Arg  Ala Gly Gln Arg Gln  Val Phe Phe Glu Leu  Asn Gly Gln 
    1070                 1075                 1080             


Leu Arg  Ser Ile Leu Val Lys  Asp Thr Gln Ala Met  Lys Glu Met 
    1085                 1090                 1095             


His Phe  His Pro Lys Ala Leu  Lys Asp Val Lys Gly  Gln Ile Gly 
    1100                 1105                 1110             


Ala Pro  Met Pro Gly Lys Val  Ile Asp Ile Lys Val  Val Ala Gly 
    1115                 1120                 1125             


Ala Lys  Val Ala Lys Gly Gln  Pro Leu Cys Val Leu  Ser Ala Met 
    1130                 1135                 1140             


Lys Met  Glu Thr Val Val Thr  Ser Pro Met Glu Gly  Thr Val Arg 
    1145                 1150                 1155             


Lys Val  His Val Thr Lys Asp  Met Thr Leu Glu Gly  Asp Asp Leu 
    1160                 1165                 1170             


Ile Leu  Glu Ile Glu 
    1175             


<210>  199
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  199
atgtcccagg actcggtgac cttcgcagac gtggctgtga acttcaccaa agaggagtgg       60

accctgctgg acccagctca gaggaatctc tacagagacg tgatgctgga aaattctagg      120

aacttggcat tcatagattg ggcaactcca tgtaaaacca aagacgcaac ccctcagccg      180

gatattcttc ctaaaagaac atttcctgaa gccaacagag tgtgtctcac gagcatcagt      240

tcccagcact ccacattaag agaagactgg agatgcccca aaacagagga accacacagg      300

cagggggtga ataatgtgaa gccacctgca gttgcccctg agaaagatga atctcctgtt      360

agcatttgtg aagatcatga aatgaggaac cactctaaac ctacctgcag gcttgtgcct      420

tcacagggag attccataag acaatgtatc ctaacacgtg actcaagtat tttcaagtat      480

aatcctgtct taaacgatag tcaaaaaaca catgaaaaca acgaagacga tggagtcttg      540

gggtggaaca ttcagtgggt tccgtgtggg agaaaaacag agctgaaatc aagcacatgg      600

actggcagtc agaacactgt gcatcatata cgtgatgaaa ttgatacggg ggccaacagg      660

caccagcgga atccatttgg aaaagctttc cgtgaagacg gatcccttag ggcacacaac      720

actcatggtc gagagaaaat gtatgatttt actcagtgcg agaacacctc cagaaataac      780

tcaattcacg ccatgcagat gcagttgtat accgcagaga caaacaagaa ggattgtcaa      840

actggggcaa cctctgccaa cgctccaaat tccggttcac acaagagtca ttgcactgga      900

gagaaaaccc ataaatgccc cgaatgtggg agagcctttt tttatcagtc attccttatg      960

agacatatga aaattcacac tggagagaaa ccgtatgaat gtgggaaatg tgggaaagcc     1020

tttagatatt ccttacacct taataaacat ttaagaaagc atgttgtgca gaagaagccc     1080

tacgaatgtg aagaatgtgg gaaagtcatt cgggagtcct caaaatatac acatataagg     1140

agccacactg gagagaaacc ctataaatgt aagacatgtg gaaaagactt tgcaaagtcg     1200

tcaggactta aaaaacatct taagactcac aaagatgaga agccctgtga atga           1254


<210>  200
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ser Gln Asp Ser Val Thr Phe Ala Asp Val Ala Val Asn Phe Thr 
1               5                   10                  15      


Lys Glu Glu Trp Thr Leu Leu Asp Pro Ala Gln Arg Asn Leu Tyr Arg 
            20                  25                  30          


Asp Val Met Leu Glu Asn Ser Arg Asn Leu Ala Phe Ile Asp Trp Ala 
        35                  40                  45              


Thr Pro Cys Lys Thr Lys Asp Ala Thr Pro Gln Pro Asp Ile Leu Pro 
    50                  55                  60                  


Lys Arg Thr Phe Pro Glu Ala Asn Arg Val Cys Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ser Gln His Ser Thr Leu Arg Glu Asp Trp Arg Cys Pro Lys Thr Glu 
                85                  90                  95      


Glu Pro His Arg Gln Gly Val Asn Asn Val Lys Pro Pro Ala Val Ala 
            100                 105                 110         


Pro Glu Lys Asp Glu Ser Pro Val Ser Ile Cys Glu Asp His Glu Met 
        115                 120                 125             


Arg Asn His Ser Lys Pro Thr Cys Arg Leu Val Pro Ser Gln Gly Asp 
    130                 135                 140                 


Ser Ile Arg Gln Cys Ile Leu Thr Arg Asp Ser Ser Ile Phe Lys Tyr 
145                 150                 155                 160 


Asn Pro Val Leu Asn Asp Ser Gln Lys Thr His Glu Asn Asn Glu Asp 
                165                 170                 175     


Asp Gly Val Leu Gly Trp Asn Ile Gln Trp Val Pro Cys Gly Arg Lys 
            180                 185                 190         


Thr Glu Leu Lys Ser Ser Thr Trp Thr Gly Ser Gln Asn Thr Val His 
        195                 200                 205             


His Ile Arg Asp Glu Ile Asp Thr Gly Ala Asn Arg His Gln Arg Asn 
    210                 215                 220                 


Pro Phe Gly Lys Ala Phe Arg Glu Asp Gly Ser Leu Arg Ala His Asn 
225                 230                 235                 240 


Thr His Gly Arg Glu Lys Met Tyr Asp Phe Thr Gln Cys Glu Asn Thr 
                245                 250                 255     


Ser Arg Asn Asn Ser Ile His Ala Met Gln Met Gln Leu Tyr Thr Ala 
            260                 265                 270         


Glu Thr Asn Lys Lys Asp Cys Gln Thr Gly Ala Thr Ser Ala Asn Ala 
        275                 280                 285             


Pro Asn Ser Gly Ser His Lys Ser His Cys Thr Gly Glu Lys Thr His 
    290                 295                 300                 


Lys Cys Pro Glu Cys Gly Arg Ala Phe Phe Tyr Gln Ser Phe Leu Met 
305                 310                 315                 320 


Arg His Met Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Lys 
                325                 330                 335     


Cys Gly Lys Ala Phe Arg Tyr Ser Leu His Leu Asn Lys His Leu Arg 
            340                 345                 350         


Lys His Val Val Gln Lys Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys 
        355                 360                 365             


Val Ile Arg Glu Ser Ser Lys Tyr Thr His Ile Arg Ser His Thr Gly 
    370                 375                 380                 


Glu Lys Pro Tyr Lys Cys Lys Thr Cys Gly Lys Asp Phe Ala Lys Ser 
385                 390                 395                 400 


Ser Gly Leu Lys Lys His Leu Lys Thr His Lys Asp Glu Lys Pro Cys 
                405                 410                 415     


Glu 
    


<210>  201
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  201
atgcgctccg ccgctgtcct ggctcttctg ctctgcgccg ggcaagtcac tgcgctccct       60

gtgaacagcc ctatgaataa aggggatacc gaggtgatga aatgcatcgt tgaggtcatc      120

tccgacacac tttccaagcc cagccccatg cctgtcagcc aggaatgttt tgagacactc      180

cgaggagatg aacggatcct ttccattctg agacatcaga atttactgaa ggagctccaa      240

gacctcgctc tccaaggcgc caaggagagg gcacatcagc agaagaaaca cagcggtttt      300

gaagatgaac tctcagaggt tcttgagaac cagagcagcc aggccgagct gaaagaggcg      360

gtggaagagc catcatccaa ggatgttatg gagaaaagag aggattccaa ggaggcagag      420

aaaagtggtg aagccacaga cggagccagg ccccaggccc tcccggagcc catgcaggag      480

tccaaggctg aggggaacaa tcaggcccct ggggaggaag aggaggagga ggaggaggcc      540

accaacaccc accctccagc cagcctcccc agccagaaat acccaggccc acaggccgag      600

ggggacagtg agggcctctc tcagggtctg gtggacagag agaagggcct gagtgcagag      660

ccagggtggc aggcaaagag agaagaggag gaggaggagg aggaggaggc tgaggctgga      720

gaggaggctg tccccgagga agaaggcccc actgtagtgc tgaaccccca cccgagcctt      780

ggctacaagg agatccggaa aggcgagagt cggtcggagg ctctggctgt ggatggagct      840

gggaagcctg gggctgagga ggctcaggac cccgaaggga agggagaaca ggagcactcc      900

cagcagaaag aggaggagga ggagatggca gtggtcccgc aaggcctctt ccggggtggg      960

aagagcggag agctggagca ggaggaggag cggctctcca aggagtggga ggactccaaa     1020

cgctggagca agatggacca gctggccaag gagctgacgg ctgagaagcg gctggagggg     1080

caggaggagg aggaggacaa ccgggacagt tccatgaagc tctccttccg ggcccgggcc     1140

tacggcttca ggggccctgg gccgcagctg cgacgaggct ggaggccatc ctcccgggag     1200

gacagccttg aggcgggcct gcccctccag gtccgaggct accccgagga gaagaaagag     1260

gaggagggca gcgcaaaccg cagaccagag gaccaggagc tggagagcct gtcggccatt     1320

gaagcagagc tggagaaagt ggcccaccag ctgcaggcac tacggcgggg ctga           1374


<210>  202
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
        115                 120                 125             


Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
    130                 135                 140                 


Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
145                 150                 155                 160 


Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 
            180                 185                 190         


Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
        195                 200                 205             


Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
    210                 215                 220                 


Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 
                245                 250                 255     


His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
            260                 265                 270         


Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
        275                 280                 285             


Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
    290                 295                 300                 


Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
305                 310                 315                 320 


Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                325                 330                 335     


Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
            340                 345                 350         


Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
        355                 360                 365             


Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
    370                 375                 380                 


Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 
385                 390                 395                 400 


Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
            420                 425                 430         


Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
        435                 440                 445             


His Gln Leu Gln Ala Leu Arg Arg Gly 
    450                 455         


<210>  203
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  203
atgaggcttt tcacaggcat tgttttctgc tccttggtca tgggagtcac cagtgaaagc       60

tggcgttcgt ttttcaagga ggctctccaa ggggttgggg acatgggcag agcctattgg      120

gacataatga tatccaatca ccaaaattca aacagatatc tctatgctcg gggaaactat      180

gatgctgccc aaagaggacc tgggggtgtc tgggctgcta aactcatcag ccgttccagg      240

gtctatcttc agggattaat agactgctat ttatttggaa acagcagcac tgtattggag      300

gactcgaagt ccaacgagaa agctgaggaa tggggccgga gtggcaaaga ccccgaccgc      360

ttcagacctg acggcctgcc taagaaatac tga                                   393


<210>  204
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  205
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  205
atgtggagcg gatggtggct gtggcccctt gtggccgtct gcactgcaga cttctttcgg       60

gacgaggcag agaggatcat gagggactcc cctgtcattg atgggcacaa tgacctcccc      120

tggcagctgc tggatatgtt caacaaccgg ctgcaggacg agagggccaa cctgaccacc      180

ttggccggca cacacaccaa catccccaag ctgagggccg gctttgtggg aggccagttc      240

tggtccgtgt acacgccctg cgacacccag aacaaagacg ccgtgcggag gacgctggag      300

cagatggacg tggtccaccg catgtgccgg atgtacccgg agaccttcct gtatgtcacc      360

agcagtgcag gcattcggca ggccttccgg gaagggaagg tggccagcct gatcggcgtg      420

gagggcggcc actccattga cagcagtttg ggcgtcctgc gggcactcta tcagctgggc      480

atgcggtacc tgaccctcac ccacagctgc aacacgccct gggctgacaa ctggctggtg      540

gacacgggag acagcgagcc ccagagccaa ggcttgtcac cctttgggca gcgtgtggtg      600

aaggagctga accgtctggg ggtcctcatc gacttggctc acgtgtctgt ggccaccatg      660

aaggccaccc tgcagctgtc cagagccccg gtcatcttca gccactcctc ggcctacagc      720

gtgtgcgcaa gccggcgcaa cgtgcctgac gacgtcctga ggctggtgaa acagacagac      780

agcctggtga tggtgaactt ctacaacaat tacatttcct gcaccaacaa ggccaacctg      840

tcccaagtgg ccgaccatct ggatcacatc aaggaggtgg caggagccag agccgtgggt      900

tttggtgggg actttgatgg tgttccaagg gtccctgagg ggctggagga cgtctccaag      960

tatccagacc tgatcgctga gctgctcagg aggaactgga cggaggcgga ggtcaagggc     1020

gcactggctg acaacctgct gagggtcttc gaggctgtgg aacaggccag caacctcaca     1080

caggctcccg aggaggagcc catcccgctg gaccagctgg gtggctcctg caggacccat     1140

tacggctact cctctggggc ttccagcctc catcgccact gggggctcct gctggcctcc     1200

ctcgctcccc tggtcctctg tctgtctctc ctgtga                               1236


<210>  206
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met Tyr 
            100                 105                 110         


Pro Glu Thr Phe Leu Tyr Val Thr Ser Ser Ala Gly Ile Arg Gln Ala 
        115                 120                 125             


Phe Arg Glu Gly Lys Val Ala Ser Leu Ile Gly Val Glu Gly Gly His 
    130                 135                 140                 


Ser Ile Asp Ser Ser Leu Gly Val Leu Arg Ala Leu Tyr Gln Leu Gly 
145                 150                 155                 160 


Met Arg Tyr Leu Thr Leu Thr His Ser Cys Asn Thr Pro Trp Ala Asp 
                165                 170                 175     


Asn Trp Leu Val Asp Thr Gly Asp Ser Glu Pro Gln Ser Gln Gly Leu 
            180                 185                 190         


Ser Pro Phe Gly Gln Arg Val Val Lys Glu Leu Asn Arg Leu Gly Val 
        195                 200                 205             


Leu Ile Asp Leu Ala His Val Ser Val Ala Thr Met Lys Ala Thr Leu 
    210                 215                 220                 


Gln Leu Ser Arg Ala Pro Val Ile Phe Ser His Ser Ser Ala Tyr Ser 
225                 230                 235                 240 


Val Cys Ala Ser Arg Arg Asn Val Pro Asp Asp Val Leu Arg Leu Val 
                245                 250                 255     


Lys Gln Thr Asp Ser Leu Val Met Val Asn Phe Tyr Asn Asn Tyr Ile 
            260                 265                 270         


Ser Cys Thr Asn Lys Ala Asn Leu Ser Gln Val Ala Asp His Leu Asp 
        275                 280                 285             


His Ile Lys Glu Val Ala Gly Ala Arg Ala Val Gly Phe Gly Gly Asp 
    290                 295                 300                 


Phe Asp Gly Val Pro Arg Val Pro Glu Gly Leu Glu Asp Val Ser Lys 
305                 310                 315                 320 


Tyr Pro Asp Leu Ile Ala Glu Leu Leu Arg Arg Asn Trp Thr Glu Ala 
                325                 330                 335     


Glu Val Lys Gly Ala Leu Ala Asp Asn Leu Leu Arg Val Phe Glu Ala 
            340                 345                 350         


Val Glu Gln Ala Ser Asn Leu Thr Gln Ala Pro Glu Glu Glu Pro Ile 
        355                 360                 365             


Pro Leu Asp Gln Leu Gly Gly Ser Cys Arg Thr His Tyr Gly Tyr Ser 
    370                 375                 380                 


Ser Gly Ala Ser Ser Leu His Arg His Trp Gly Leu Leu Leu Ala Ser 
385                 390                 395                 400 


Leu Ala Pro Leu Val Leu Cys Leu Ser Leu Leu 
                405                 410     


<210>  207
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  207
atgaagagcc tgatccttct tgccatcctg gccgccttag cggtagtaac tttgtgttat       60

gaatcacatg aaagcatgga atcttatgaa cttaatccct tcattaacag gagaaatgca      120

aataccttca tatcccctca gcagagatgg agagctaaag tccaagagag gatccgagaa      180

cgctctaagc ctgtccacga gctcaatagg gaagcctgtg atgactacag actttgcgaa      240

cgctacgcca tggtttatgg atacaatgct gcctataatc gctacttcag gaagcgccga      300

gggaccaaat ga                                                          312


<210>  208
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
1               5                   10                  15      


Thr Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn 
            20                  25                  30          


Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln 
        35                  40                  45              


Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro 
    50                  55                  60                  


Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu 
65                  70                  75                  80  


Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
                85                  90                  95      


Arg Lys Arg Arg Gly Thr Lys 
            100             


<210>  209
<211>  1974
<212>  DNA
<213>  Homo sapiens

<400>  209
atggaaatgg aaaccaccga acctgagcca gactgtgtag tgcagcctcc ctctcctcct       60

gatgactttt catgccaaat gagactctct gagaagatca ctccattgaa gacttgtttt      120

aagaaaaagg atcagaaaag attgggaact ggaaccctga ggtctttgag gccaatatta      180

aacactcttc tagaatctgg ctcacttgat ggggttttta gatctaggaa ccagagtaca      240

gatgagaaca gcttacatga acctatgatg aagaaagcca tggaaatcaa ttcatcatgc      300

ccaccagcag aaaataatat gtctgttctg attcctgata ggacaaatgt tggggaccag      360

ataccggaag cccatccttc cactgaagct ccagaacgag tggttccaat ccaagatcac      420

agctttccat cagaaaccct cagtgggacg gtggcagatt ccacaccagc tcacttccag      480

actgatcttt tgcacccagt ttcaagtgat gttcctacta gtcctgactg cttagacaaa      540

gtcatagatt atgttccagg cattttccaa gaaaacagtt ttacaatcca atacattctg      600

gacaccagtg ataagctgag tactgagctc tttcaggaca aaagtgaaga ggcttccctt      660

gacctcgtgt ttgagctggt gaaccagttg cagtaccaca ctcaccaaga gaacggaatt      720

gaaatttgca tggactttct gcaaggcact tgtatttatg gcagggattg tttgaagcac      780

cacactgtct tgccatatca ttggcagatc aaaaggacaa ctactcaaaa gtggcagagt      840

gtattcaatg attctcagga gcacttggaa agattttact gtaacccaga aaatgataga      900

atgagaatga agtatggagg acaagaattt tgggcagatt tgaatgccat gaacgtgtat      960

gaaacaactg aatttgacca actacgaagg ctgtccacac caccctctag caatgtcaac     1020

tctatttacc acacagtctg gaaattcttc tgtagggacc actttggatg gagagagtat     1080

cccgagtctg tcattcgatt gattgaagaa gccaactctc ggggtctgaa agaggttcga     1140

tttatgatgt ggaataacca ctacatcctc cacaattcat tcttcaggag agagataaaa     1200

aggagacccc tcttccgctc ctgttttata ctgcttccat atttacagac acttggtggg     1260

gttcccacac aagctcctcc acctcttgaa gcaacttcat catcacaaat tatctgccca     1320

gatggggtca cttcagcaaa cttttaccct gaaacttggg tttatatgca tccatctcag     1380

gacttcatcc aagtccctgt ttctgcagag gataaaagtt atcggatcat ttacaatctt     1440

tttcataaga ctgtgcctga gtttaaatac agaattttgc agatattgag agtccaaaac     1500

cagtttcttt gggagaaata taaaaggaaa aaggaatata tgaacaggaa aatgtttggc     1560

cgtgacagga taataaatga gagacattta tttcatggaa catcccagga tgtggtagat     1620

ggaatctgca aacacaactt tgaccctcga gtctgtggaa agcatgctac aatgtttgga     1680

caaggcagtt attttgcaaa gaaggcaagc tactctcata acttttctaa gaagtcctcc     1740

aaaggagtcc acttcatgtt tctggccaaa gtgctgacgg gcagatacac aatgggcagt     1800

catggcatga gaaggccccc gccagtcaat cctggcagtg tcaccagtga cctttatgac     1860

tcttgtgtgg ataatttctt tgagcctcag atttttgtca tttttaatga tgaccagagt     1920

tacccttatt ttgttatcca atatgaagaa gtcagtaaca ctgtttccat ttga           1974


<210>  210
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Glu Met Glu Thr Thr Glu Pro Glu Pro Asp Cys Val Val Gln Pro 
1               5                   10                  15      


Pro Ser Pro Pro Asp Asp Phe Ser Cys Gln Met Arg Leu Ser Glu Lys 
            20                  25                  30          


Ile Thr Pro Leu Lys Thr Cys Phe Lys Lys Lys Asp Gln Lys Arg Leu 
        35                  40                  45              


Gly Thr Gly Thr Leu Arg Ser Leu Arg Pro Ile Leu Asn Thr Leu Leu 
    50                  55                  60                  


Glu Ser Gly Ser Leu Asp Gly Val Phe Arg Ser Arg Asn Gln Ser Thr 
65                  70                  75                  80  


Asp Glu Asn Ser Leu His Glu Pro Met Met Lys Lys Ala Met Glu Ile 
                85                  90                  95      


Asn Ser Ser Cys Pro Pro Ala Glu Asn Asn Met Ser Val Leu Ile Pro 
            100                 105                 110         


Asp Arg Thr Asn Val Gly Asp Gln Ile Pro Glu Ala His Pro Ser Thr 
        115                 120                 125             


Glu Ala Pro Glu Arg Val Val Pro Ile Gln Asp His Ser Phe Pro Ser 
    130                 135                 140                 


Glu Thr Leu Ser Gly Thr Val Ala Asp Ser Thr Pro Ala His Phe Gln 
145                 150                 155                 160 


Thr Asp Leu Leu His Pro Val Ser Ser Asp Val Pro Thr Ser Pro Asp 
                165                 170                 175     


Cys Leu Asp Lys Val Ile Asp Tyr Val Pro Gly Ile Phe Gln Glu Asn 
            180                 185                 190         


Ser Phe Thr Ile Gln Tyr Ile Leu Asp Thr Ser Asp Lys Leu Ser Thr 
        195                 200                 205             


Glu Leu Phe Gln Asp Lys Ser Glu Glu Ala Ser Leu Asp Leu Val Phe 
    210                 215                 220                 


Glu Leu Val Asn Gln Leu Gln Tyr His Thr His Gln Glu Asn Gly Ile 
225                 230                 235                 240 


Glu Ile Cys Met Asp Phe Leu Gln Gly Thr Cys Ile Tyr Gly Arg Asp 
                245                 250                 255     


Cys Leu Lys His His Thr Val Leu Pro Tyr His Trp Gln Ile Lys Arg 
            260                 265                 270         


Thr Thr Thr Gln Lys Trp Gln Ser Val Phe Asn Asp Ser Gln Glu His 
        275                 280                 285             


Leu Glu Arg Phe Tyr Cys Asn Pro Glu Asn Asp Arg Met Arg Met Lys 
    290                 295                 300                 


Tyr Gly Gly Gln Glu Phe Trp Ala Asp Leu Asn Ala Met Asn Val Tyr 
305                 310                 315                 320 


Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg Leu Ser Thr Pro Pro Ser 
                325                 330                 335     


Ser Asn Val Asn Ser Ile Tyr His Thr Val Trp Lys Phe Phe Cys Arg 
            340                 345                 350         


Asp His Phe Gly Trp Arg Glu Tyr Pro Glu Ser Val Ile Arg Leu Ile 
        355                 360                 365             


Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu Val Arg Phe Met Met Trp 
    370                 375                 380                 


Asn Asn His Tyr Ile Leu His Asn Ser Phe Phe Arg Arg Glu Ile Lys 
385                 390                 395                 400 


Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile Leu Leu Pro Tyr Leu Gln 
                405                 410                 415     


Thr Leu Gly Gly Val Pro Thr Gln Ala Pro Pro Pro Leu Glu Ala Thr 
            420                 425                 430         


Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly Val Thr Ser Ala Asn Phe 
        435                 440                 445             


Tyr Pro Glu Thr Trp Val Tyr Met His Pro Ser Gln Asp Phe Ile Gln 
    450                 455                 460                 


Val Pro Val Ser Ala Glu Asp Lys Ser Tyr Arg Ile Ile Tyr Asn Leu 
465                 470                 475                 480 


Phe His Lys Thr Val Pro Glu Phe Lys Tyr Arg Ile Leu Gln Ile Leu 
                485                 490                 495     


Arg Val Gln Asn Gln Phe Leu Trp Glu Lys Tyr Lys Arg Lys Lys Glu 
            500                 505                 510         


Tyr Met Asn Arg Lys Met Phe Gly Arg Asp Arg Ile Ile Asn Glu Arg 
        515                 520                 525             


His Leu Phe His Gly Thr Ser Gln Asp Val Val Asp Gly Ile Cys Lys 
    530                 535                 540                 


His Asn Phe Asp Pro Arg Val Cys Gly Lys His Ala Thr Met Phe Gly 
545                 550                 555                 560 


Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser Tyr Ser His Asn Phe Ser 
                565                 570                 575     


Lys Lys Ser Ser Lys Gly Val His Phe Met Phe Leu Ala Lys Val Leu 
            580                 585                 590         


Thr Gly Arg Tyr Thr Met Gly Ser His Gly Met Arg Arg Pro Pro Pro 
        595                 600                 605             


Val Asn Pro Gly Ser Val Thr Ser Asp Leu Tyr Asp Ser Cys Val Asp 
    610                 615                 620                 


Asn Phe Phe Glu Pro Gln Ile Phe Val Ile Phe Asn Asp Asp Gln Ser 
625                 630                 635                 640 


Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu Val Ser Asn Thr Val Ser 
                645                 650                 655     


Ile 
    


<210>  211
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  211
atgaaagctg cggtgctgac cttggccgtg ctcttcctga cggggagcca ggctcggcat       60

ttctggcagc aagatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      120

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      180

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc      240

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa      300

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag      360

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc      420

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag      480

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg      540

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg      600

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc      660

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa      720

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac      780

actaagaagc tcaacaccca gtga                                             804


<210>  212
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  213
<211>  2883
<212>  DNA
<213>  Homo sapiens

<400>  213
atgttccatt cttctgcaat ggttaattca cacagaaaac caatgtttaa cattcacaga       60

ggattttact gcttaacagc catcttgccc caaatatgca tttgttctca gttctcagtg      120

ccatctagtt atcacttcac tgaggatcct ggggctttcc cagtagccac taatggggaa      180

cgatttcctt ggcaggagct aaggctcccc agtgtggtca ttcctctcca ttatgacctc      240

tttgtccacc ccaatctcac ctctctggac tttgttgcat ctgagaagat cgaagtcttg      300

gtcagcaatg ctacccagtt tatcatcttg cacagcaaag atcttgaaat cacgaatgcc      360

acccttcagt cagaggaaga ttcaagatac atgaaaccag gaaaagaact gaaagttttg      420

agttaccctg ctcatgaaca aattgcactg ctggttccag agaaacttac gcctcacctg      480

aaatactatg tggctatgga cttccaagcc aagttaggtg atggctttga agggttttat      540

aaaagcacat acagaactct tggtggtgaa acaagaattc ttgcagtaac agattttgag      600

ccaacccagg cacgcatggc tttcccttgc tttgatgaac cgttgttcaa agccaacttt      660

tcaatcaaga tacgaagaga gagcaggcat attgcactat ccaacatgcc aaaggttaag      720

acaattgaac ttgaaggagg tcttttggaa gatcactttg aaactactgt aaaaatgagt      780

acataccttg tagcctacat agtttgtgat ttccactctc tgagtggctt cacttcatca      840

ggggtcaagg tgtccatcta tgcatcccca gacaaacgga atcaaacaca ttatgctttg      900

caggcatcac tgaagctact tgatttttat gaaaagtact ttgatatcta ctatccactc      960

tccaaactgg atttaattgc tattcctgac tttgcacctg gagccatgga aaattggggc     1020

ctcattacat atagggagac gtcactgctt tttgacccca agacctcttc tgcttccgat     1080

aaactgtggg tcaccagagt catagcccat gaactggcgc accagtggtt tggcaacctg     1140

gtcacaatgg aatggtggaa tgatatttgg cttaaggagg gttttgcaaa atacatggaa     1200

cttatcgctg ttaatgctac atatccagag ctgcaatttg atgactattt tttgaatgtg     1260

tgttttgaag taattacaaa agattcattg aattcatccc gccctatctc caaaccagcg     1320

gaaaccccga ctcaaataca ggaaatgttt gatgaagttt cctataacaa gggagcttgt     1380

attttgaata tgctcaagga ttttctgggt gaggagaaat tccagaaagg aataattcag     1440

tacttaaaga agttcagcta tagaaatgct aagaatgatg acttgtggag cagtctgtca     1500

aatagttgtt tagaaagtga ttttacatct ggtggagttt gtcattcgga tcccaagatg     1560

acaagtaaca tgctcgcctt tctgggggaa aatgcagagg tcaaagagat gatgactaca     1620

tggactctcc agaaaggaat ccccctgctg gtggttaaac aagacgggtg ttcactccga     1680

ctgcaacagg agcgcttcct ccagggggtt ttccaggaag accctgaatg gagggccctg     1740

caggagaggt acctgtggca tatcccattg acctactcca cgagttcttc taatgtgatc     1800

cacagacaca ttctaaaatc aaagacagat actctggatc tacctgaaaa gaccagttgg     1860

gtgaaattta atgtggactc aaatggttac tacatcgttc actatgaggg tcatggatgg     1920

gaccaactca ttacacagct gaatcagaac cacacacttc tcagacctaa ggacagagta     1980

ggtctgattc atgatgtgtt tcagctagtt ggtgcaggga gactgaccct agacaaagct     2040

cttgacatga cttactacct ccaacatgaa acaagcagcc ccgcacttct cgaaggtctg     2100

agttacttgg aatcgtttta ccacatgatg gacagaagga atatttcaga tatctctgaa     2160

aacctcaagc gttaccttct tcagtatttt aagccagtga ttgacaggca aagctggagt     2220

gacaagggct cagtctggga caggatgctc cgctcggctc tcttgaagct ggcctgtgac     2280

ctgaaccatg ctccttgcat ccagaaagct gctgaactct tctcccagtg gatggaatcc     2340

agtggaaaat taaatatacc aacagatgtt ttaaagattg tgtattctgt gggtgctcag     2400

acaacagcag gatggaatta ccttttagag caatatgaac tgtcaatgtc aagtgctgaa     2460

caaaacaaaa ttctgtatgc tttgtcaacg agcaagcatc aggaaaagtt actgaagtta     2520

attgaactag gaatggaagg aaaggttatc aagacacaga acttggcagc tctccttcat     2580

gcgattgcca gacgtccaaa ggggcagcaa ctagcatggg attttgtaag agaaaattgg     2640

acccatcttc tgaaaaaatt tgacttgggc tcatatgaca taaggatgat catctctggc     2700

acaacagctc acttttcttc caaggataag ttgcaagagg tgaaactatt ttttgaatct     2760

cttgaggctc aaggatcaca tctggatatt tttcaaactg ttctggaaac gataaccaaa     2820

aatataaaat ggctggagaa gaatcttccg actctgagga cttggctaat ggttaatact     2880

taa                                                                   2883


<210>  214
<211>  960
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met 
                325                 330                 335     


Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp 
            340                 345                 350         


Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile 
        355                 360                 365             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu 
    370                 375                 380                 


Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu 
385                 390                 395                 400 


Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr 
                405                 410                 415     


Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser 
            420                 425                 430         


Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu 
        435                 440                 445             


Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met 
    450                 455                 460                 


Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp 
                485                 490                 495     


Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly 
            500                 505                 510         


Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu Ala Phe Leu 
        515                 520                 525             


Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp Thr Leu Gln 
    530                 535                 540                 


Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys Ser Leu Arg 
545                 550                 555                 560 


Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu Asp Pro Glu 
                565                 570                 575     


Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro Leu Thr Tyr 
            580                 585                 590         


Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu Lys Ser Lys 
        595                 600                 605             


Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val Lys Phe Asn 
    610                 615                 620                 


Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly His Gly Trp 
625                 630                 635                 640 


Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu Leu Arg Pro 
                645                 650                 655     


Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu Val Gly Ala 
            660                 665                 670         


Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr Tyr Leu Gln 
        675                 680                 685             


His Glu Thr Ser Ser Pro Ala Leu Leu Glu Gly Leu Ser Tyr Leu Glu 
    690                 695                 700                 


Ser Phe Tyr His Met Met Asp Arg Arg Asn Ile Ser Asp Ile Ser Glu 
705                 710                 715                 720 


Asn Leu Lys Arg Tyr Leu Leu Gln Tyr Phe Lys Pro Val Ile Asp Arg 
                725                 730                 735     


Gln Ser Trp Ser Asp Lys Gly Ser Val Trp Asp Arg Met Leu Arg Ser 
            740                 745                 750         


Ala Leu Leu Lys Leu Ala Cys Asp Leu Asn His Ala Pro Cys Ile Gln 
        755                 760                 765             


Lys Ala Ala Glu Leu Phe Ser Gln Trp Met Glu Ser Ser Gly Lys Leu 
    770                 775                 780                 


Asn Ile Pro Thr Asp Val Leu Lys Ile Val Tyr Ser Val Gly Ala Gln 
785                 790                 795                 800 


Thr Thr Ala Gly Trp Asn Tyr Leu Leu Glu Gln Tyr Glu Leu Ser Met 
                805                 810                 815     


Ser Ser Ala Glu Gln Asn Lys Ile Leu Tyr Ala Leu Ser Thr Ser Lys 
            820                 825                 830         


His Gln Glu Lys Leu Leu Lys Leu Ile Glu Leu Gly Met Glu Gly Lys 
        835                 840                 845             


Val Ile Lys Thr Gln Asn Leu Ala Ala Leu Leu His Ala Ile Ala Arg 
    850                 855                 860                 


Arg Pro Lys Gly Gln Gln Leu Ala Trp Asp Phe Val Arg Glu Asn Trp 
865                 870                 875                 880 


Thr His Leu Leu Lys Lys Phe Asp Leu Gly Ser Tyr Asp Ile Arg Met 
                885                 890                 895     


Ile Ile Ser Gly Thr Thr Ala His Phe Ser Ser Lys Asp Lys Leu Gln 
            900                 905                 910         


Glu Val Lys Leu Phe Phe Glu Ser Leu Glu Ala Gln Gly Ser His Leu 
        915                 920                 925             


Asp Ile Phe Gln Thr Val Leu Glu Thr Ile Thr Lys Asn Ile Lys Trp 
    930                 935                 940                 


Leu Glu Lys Asn Leu Pro Thr Leu Arg Thr Trp Leu Met Val Asn Thr 
945                 950                 955                 960 


<210>  215
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  215
atgctgttgc tgggagctgt tctactgcta ttagctctgc ccggtcatga ccaggaaacc       60

acgactcaag ggcccggagt cctgcttccc ctgcccaagg gggcctgcac aggttggatg      120

gcgggcatcc cagggcatcc gggccataat ggggccccag gccgtgatgg cagagatggc      180

acccctggtg agaagggtga gaaaggagat ccaggtctta ttggtcctaa gggagacatc      240

ggtgaaaccg gagtacccgg ggctgaaggt ccccgaggct ttccgggaat ccaaggcagg      300

aaaggagaac ctggagaagg tgcctatgta taccgctcag cattcagtgt gggattggag      360

acttacgtta ctatccccaa catgcccatt cgctttacca agatcttcta caatcagcaa      420

aaccactatg atggctccac tggtaaattc cactgcaaca ttcctgggct gtactacttt      480

gcctaccaca tcacagtcta tatgaaggat gtgaaggtca gcctcttcaa gaaggacaag      540

gctatgctct tcacctatga tcagtaccag gaaaataatg tggaccaggc ctccggctct      600

gtgctcctgc atctggaggt gggcgaccaa gtctggctcc aggtgtatgg ggaaggagag      660

cgtaatggac tctatgctga taatgacaat gactccacct tcacaggctt tcttctctac      720

catgacacca actga                                                       735


<210>  216
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  217
<211>  1461
<212>  DNA
<213>  Homo sapiens

<400>  217
atgctgggca aggattacat gctggccatc attctggtca actgcgatga tgacttgtgg       60

ggggaccaca gtctggaggt ggaggctggc ctgcctcctg gctggaggaa gatccacgat      120

gctgcaggta cttactactg gcatgtaccc agcggtagca cccagtggca gcgcccaacc      180

tgggaactag gagatgcaga ggacccaggc acgggaacgg aggggatctg gggactgcgg      240

ccccccaaag ggagatcctt ctccagcctg gagagttcac tggaccggag taactctctg      300

tcctggtatg gtggggaatc ctacatccag agcatggagc caggggctaa gtgctttgca      360

gtccgctctc tgggctgggt agaggtacct gaagaggacc tggcaccggg gaagagcagt      420

attgcagtca ataactgtat ccagcagctg gcccagaccc gcagccggag ccagcctcca      480

gatggtgcct ggggtgaggg ccagaacatg ctgatgatcc tgaagaagga tgccatgagc      540

ctagtgaatc ccctggacca cagtctgatc cactgccagc ctctggtgca catccgtgtg      600

tggggcgtgg ggagctccaa gggccgtgac agggacttcg cttttgtggc aagtgacaaa      660

gatagctgta tgctcaagtg ccatgtgttt cgctgtgatg tccctgccaa ggccattgcc      720

agtgccctac atgggctttg tgcccagatc ttgtcagagc gagtagaggt cagtggtgat      780

gcctcttgct gctccccaga ccccatctct cctgaagacc tgccacggca agtggagctg      840

ctagatgcgg taagccaagc tgctcagaag tacgaggcac tgtatatggg gacactgcca      900

gtcaccaagg ccatgggcat ggatgtgctg aacgaggcca ttggtaccct cactgccagg      960

ggggaccgga atgcctgggt ccccaccatg ctcagtgtgt ctgactctct catgactgca     1020

catcccattc aggcagaggc cagtacagag gaggagccat tgtggcagtg ccctgtgcgc     1080

cttgtgacat ttattggtgt tggccgcgac ccacacacct ttggcctcat cgctgacctg     1140

ggccgtcaga gcttccagtg cgcagccttc tggtgccagc cccatgcagg gggactctct     1200

gaagctgtgc aggctgcctg tatggttcag taccagaagt gtcttgtggc ctctgcagct     1260

cgaggcaagg cctggggtgc ccaggcccgt gcccgcctgc ggctcaagcg gaccagctcc     1320

atggattccc caggaggtcc cctgcccctc cccctgctca aaggaggggt tggcggtgca     1380

ggggcaaccc ctcgaaagcg gggtgtcttc tcttttcttg atgccttccg gctgaaaccc     1440

tctctgctcc atatgcccta a                                               1461


<210>  218
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
1               5                   10                  15      


Asp Asp Leu Trp Gly Asp His Ser Leu Glu Val Glu Ala Gly Leu Pro 
            20                  25                  30          


Pro Gly Trp Arg Lys Ile His Asp Ala Ala Gly Thr Tyr Tyr Trp His 
        35                  40                  45              


Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Gly 
    50                  55                  60                  


Asp Ala Glu Asp Pro Gly Thr Gly Thr Glu Gly Ile Trp Gly Leu Arg 
65                  70                  75                  80  


Pro Pro Lys Gly Arg Ser Phe Ser Ser Leu Glu Ser Ser Leu Asp Arg 
                85                  90                  95      


Ser Asn Ser Leu Ser Trp Tyr Gly Gly Glu Ser Tyr Ile Gln Ser Met 
            100                 105                 110         


Glu Pro Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
        115                 120                 125             


Val Pro Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn 
    130                 135                 140                 


Asn Cys Ile Gln Gln Leu Ala Gln Thr Arg Ser Arg Ser Gln Pro Pro 
145                 150                 155                 160 


Asp Gly Ala Trp Gly Glu Gly Gln Asn Met Leu Met Ile Leu Lys Lys 
                165                 170                 175     


Asp Ala Met Ser Leu Val Asn Pro Leu Asp His Ser Leu Ile His Cys 
            180                 185                 190         


Gln Pro Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly 
        195                 200                 205             


Arg Asp Arg Asp Phe Ala Phe Val Ala Ser Asp Lys Asp Ser Cys Met 
    210                 215                 220                 


Leu Lys Cys His Val Phe Arg Cys Asp Val Pro Ala Lys Ala Ile Ala 
225                 230                 235                 240 


Ser Ala Leu His Gly Leu Cys Ala Gln Ile Leu Ser Glu Arg Val Glu 
                245                 250                 255     


Val Ser Gly Asp Ala Ser Cys Cys Ser Pro Asp Pro Ile Ser Pro Glu 
            260                 265                 270         


Asp Leu Pro Arg Gln Val Glu Leu Leu Asp Ala Val Ser Gln Ala Ala 
        275                 280                 285             


Gln Lys Tyr Glu Ala Leu Tyr Met Gly Thr Leu Pro Val Thr Lys Ala 
    290                 295                 300                 


Met Gly Met Asp Val Leu Asn Glu Ala Ile Gly Thr Leu Thr Ala Arg 
305                 310                 315                 320 


Gly Asp Arg Asn Ala Trp Val Pro Thr Met Leu Ser Val Ser Asp Ser 
                325                 330                 335     


Leu Met Thr Ala His Pro Ile Gln Ala Glu Ala Ser Thr Glu Glu Glu 
            340                 345                 350         


Pro Leu Trp Gln Cys Pro Val Arg Leu Val Thr Phe Ile Gly Val Gly 
        355                 360                 365             


Arg Asp Pro His Thr Phe Gly Leu Ile Ala Asp Leu Gly Arg Gln Ser 
    370                 375                 380                 


Phe Gln Cys Ala Ala Phe Trp Cys Gln Pro His Ala Gly Gly Leu Ser 
385                 390                 395                 400 


Glu Ala Val Gln Ala Ala Cys Met Val Gln Tyr Gln Lys Cys Leu Val 
                405                 410                 415     


Ala Ser Ala Ala Arg Gly Lys Ala Trp Gly Ala Gln Ala Arg Ala Arg 
            420                 425                 430         


Leu Arg Leu Lys Arg Thr Ser Ser Met Asp Ser Pro Gly Gly Pro Leu 
        435                 440                 445             


Pro Leu Pro Leu Leu Lys Gly Gly Val Gly Gly Ala Gly Ala Thr Pro 
    450                 455                 460                 


Arg Lys Arg Gly Val Phe Ser Phe Leu Asp Ala Phe Arg Leu Lys Pro 
465                 470                 475                 480 


Ser Leu Leu His Met Pro 
                485     


<210>  219
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  219
gggagtgcat ccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat       60

acgagcagcg tggccgttgg ctgcctcgca caggacttcc ttcccgactc catcactttc      120

tcctggaaat acaagaacaa ctctgacatc agcagcaccc ggggcttccc atcagtcctg      180

agagggggca agtacgcagc cacctcacag gtgctgctgc cttccaagga cgtcatgcag      240

ggcacagacg aacacgtggt gtgcaaagtc cagcacccca acggcaacaa agaaaagaac      300

gtgcctcttc cagtgattgc cgagctgcct cccaaagtga gcgtcttcgt cccaccccgc      360

gacggcttct tcggcaaccc ccgcaagtcc aagctcatct gccaggccac gggtttcagt      420

ccccggcaga ttcaggtgtc ctggctgcgc gaggggaagc aggtggggtc tggcgtcacc      480

acggaccagg tgcaggctga ggccaaagag tctgggccca cgacctacaa ggtgaccagc      540

acactgacca tcaaagagag cgactggctc agccagagca tgttcacctg ccgcgtggat      600

cacaggggcc tgaccttcca gcagaatgcg tcctccatgt gtggccccga tcaagacaca      660

gccatccggg tcttcgccat ccccccatcc tttgccagca tcttcctcac caagtccacc      720

aagttgacct gcctggtcac agacctgacc acctatgaca gcgtgaccat ctcctggacc      780

cgccagaatg gcgaagctgt gaaaacccac accaacatct ccgagagcca ccccaatgcc      840

actttcagcg ccgtgggtga ggccagcatc tgcgaggatg actggaattc cggggagagg      900

ttcacgtgca ccgtgaccca cacagacctg ccctcgccac tgaagcagac catctcccgg      960

cccaaggggg tggccctgca caggcccgat gtctacttgc tgccaccagc ccgggagcag     1020

ctgaacctgc gggagtcggc caccatcacg tgcctggtga cgggcttctc tcccgcggac     1080

gtcttcgtgc agtggatgca gagggggcag cccttgtccc cggagaagta tgtgaccagc     1140

gccccaatgc ctgagcccca ggccccaggc cggtacttcg cccacagcat cctgaccgtg     1200

tccgaagagg aatggaacac gggggagacc tacacctgcg tggtggccca tgaggccctg     1260

cccaacaggg tcaccgagag gaccgtggac aagtccaccg gtaaacccac cctgtacaac     1320

gtgtccctgg tcatgtccga cacagctggc acctgctact ga                        1362


<210>  220
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  220

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Gly Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  221
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  221
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagcgt gcttgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agaacctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcaacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaaga caggaagtat tttcatcata attctgactt ccacattcca      480

aaagccacac tcaaagatag cggctcctac ttctgcaggg ggcttgttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctctc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattt ga                         702


<210>  222
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Asn Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210>  223
<211>  2724
<212>  DNA
<213>  Homo sapiens

<400>  223
gtggagagtg cgattgcaga agggggtgct tctcgtttca gtgcttcttc gggcggagga       60

ggaagtaggg gtgcacctca gcactatccc aagactgctg gcaacagcga gttcctgggg      120

aaaaccccag ggcaaaacgc tcagaaatgg attcctgcac gaagcactag acgagatgac      180

aactccgcag caaacaactc cgcaaacgaa aaagaacgac atgatgcaat cttcaggaaa      240

gtaagaggca tactaaataa gcttactcct gaaaagtttg acaagctatg ccttgagctc      300

ctcaatgtgg gtgtagagtc taaactcatc cttaaagggg tcatactgct gattgtggac      360

aaagccctag aagagccaaa gtatagctca ctgtatgctc agctatgtct gcgattggca      420

gaagatgcac caaactttga tggcccagca gcagagggtc aaccaggaca gaagcaaagc      480

accacattca gacgcctcct aatttccaaa ttacaagatg aatttgaaaa ccgaactaga      540

aatgttgatg tctatgataa gcgtgaaaat cccctcctcc ccgaggagga ggaacagaga      600

gccattgcta agatcaagat gttgggaaac atcaaattca ttggagagct tggcaagctt      660

gatcttattc acgaatctat ccttcataag tgcatcaaaa cacttttgga aaagaagaag      720

agagtccaac tcaaagatat gggagaggat ttggagtgcc tctgtcagat aatgaggaca      780

gtgggaccta gattagacca tgaacgagcc aagtccttaa tggatcagta ctttgcccga      840

atgtgctcct tgatgttaag taaggaattg ccagcaagga ttcgtttcct gctgcaggat      900

accgtagagt tgcgagaaca ccattgggtt cctcgcaagg cttttcttga caatggacca      960

aagacgatca atcaaattcg tcaagatgca gtaaaagatc taggggtgtt tattcctgct     1020

cctatggctc aagggatgag aagtgacttc tttctggagg gaccgttcat gccacccagg     1080

atgaaaatgg atagggaccc acttggagga cttgctgata tgtttggaca aatgccaggt     1140

agcggaattg gtactggtcc aggagttatc caggatagat tttcacccac catgggacgt     1200

catcgttcaa atcaactctt caatggccat gggggacaca tcatgcctcc cacacaatcg     1260

cagtttggag agatgggagg caagtttatg aaaagccagg ggctaagcca gctctaccat     1320

aaccagagtc agggactctt atcccagctg caaggacagt cgaaggatat gccacctcgg     1380

ttttctaaga aaggacagct taatgcagat gagattagcc tgaggcctgc tcagtcgttc     1440

ctaatgaata aaaatcaagt gccaaagctt cagccccaga taactatgat tcctcctagt     1500

gcacaaccac cacgcactca aacaccacct ctgggacaga cacctcagct tggtctcaaa     1560

actaatccac cgcttatcca ggaaaagcct gccaagacca gcaaaaagcc accaccgtca     1620

aaggaagaac tccttaaact aactgaaact gttgtgactg aatatctaaa tagtggaaat     1680

gcaaatgagg ctgtcaatgg tgtaagagaa atgagggctc ctaaacactt tcttcctgag     1740

atgttaagca aagtaatcat cctgtcacta gatagaagcg atgaagataa agaaaaagca     1800

agttctttga tcagtttact caaacaggaa gggatagcca caagtgacaa cttcatgcag     1860

gctttcctga atgtattgga ccagtgtccc aaactggagg ttgacatccc tttggtgaaa     1920

tcctatttag cacagtttgc agctcgtgcc atcatttcag agctggtgag catttcagaa     1980

ctagctcaac cactagaaag tggcacccat tttcctctct tcctactttg tcttcagcag     2040

ttagctaaat tacaagatcg agaatggtta acagaacttt ttcaacaaag caaggtcaat     2100

atgcagaaaa tgctcccaga aattgatcag aataaggacc gcatgttgga gattttggaa     2160

ggaaagggac tgagtttctt attcccactc ctcaaattgg agaaggaact gttgaagcaa     2220

ataaagttgg atccatcccc tcaaaccata tataaatgga ttaaagataa catctctccc     2280

aaacttcatg tagataaagg atttgtgaac atcttaatga ctagcttctt acagtacatt     2340

tctagtgaag taaacccccc cagcgatgaa acagattcat cctctgctcc ttccaaagaa     2400

cagttagagc aggaaaaaca actactacta tctttcaagc cagtaatgca gaaatttctt     2460

catgatcacg ttgatctaca agtcagtgcc ctgtatgctc tccaggtgca ctgctataac     2520

agcaacttcc caaaaggcat gttacttcgc ttttttgtgc acttctatga catggaaatt     2580

attgaagaag aagctttctt ggcttggaaa gaagatataa cccaagagtt tccgggaaaa     2640

ggcaaggctt tgttccaggt gaatcagtgg ctaacctggt tagaaactgc tgaagaagaa     2700

gaatcagagg aagaagctga ctaa                                            2724


<210>  224
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Glu Ser Ala Ile Ala Glu Gly Gly Ala Ser Arg Phe Ser Ala Ser 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Arg Gly Ala Pro Gln His Tyr Pro Lys Thr 
            20                  25                  30          


Ala Gly Asn Ser Glu Phe Leu Gly Lys Thr Pro Gly Gln Asn Ala Gln 
        35                  40                  45              


Lys Trp Ile Pro Ala Arg Ser Thr Arg Arg Asp Asp Asn Ser Ala Ala 
    50                  55                  60                  


Asn Asn Ser Ala Asn Glu Lys Glu Arg His Asp Ala Ile Phe Arg Lys 
65                  70                  75                  80  


Val Arg Gly Ile Leu Asn Lys Leu Thr Pro Glu Lys Phe Asp Lys Leu 
                85                  90                  95      


Cys Leu Glu Leu Leu Asn Val Gly Val Glu Ser Lys Leu Ile Leu Lys 
            100                 105                 110         


Gly Val Ile Leu Leu Ile Val Asp Lys Ala Leu Glu Glu Pro Lys Tyr 
        115                 120                 125             


Ser Ser Leu Tyr Ala Gln Leu Cys Leu Arg Leu Ala Glu Asp Ala Pro 
    130                 135                 140                 


Asn Phe Asp Gly Pro Ala Ala Glu Gly Gln Pro Gly Gln Lys Gln Ser 
145                 150                 155                 160 


Thr Thr Phe Arg Arg Leu Leu Ile Ser Lys Leu Gln Asp Glu Phe Glu 
                165                 170                 175     


Asn Arg Thr Arg Asn Val Asp Val Tyr Asp Lys Arg Glu Asn Pro Leu 
            180                 185                 190         


Leu Pro Glu Glu Glu Glu Gln Arg Ala Ile Ala Lys Ile Lys Met Leu 
        195                 200                 205             


Gly Asn Ile Lys Phe Ile Gly Glu Leu Gly Lys Leu Asp Leu Ile His 
    210                 215                 220                 


Glu Ser Ile Leu His Lys Cys Ile Lys Thr Leu Leu Glu Lys Lys Lys 
225                 230                 235                 240 


Arg Val Gln Leu Lys Asp Met Gly Glu Asp Leu Glu Cys Leu Cys Gln 
                245                 250                 255     


Ile Met Arg Thr Val Gly Pro Arg Leu Asp His Glu Arg Ala Lys Ser 
            260                 265                 270         


Leu Met Asp Gln Tyr Phe Ala Arg Met Cys Ser Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Leu Pro Ala Arg Ile Arg Phe Leu Leu Gln Asp Thr Val Glu Leu 
    290                 295                 300                 


Arg Glu His His Trp Val Pro Arg Lys Ala Phe Leu Asp Asn Gly Pro 
305                 310                 315                 320 


Lys Thr Ile Asn Gln Ile Arg Gln Asp Ala Val Lys Asp Leu Gly Val 
                325                 330                 335     


Phe Ile Pro Ala Pro Met Ala Gln Gly Met Arg Ser Asp Phe Phe Leu 
            340                 345                 350         


Glu Gly Pro Phe Met Pro Pro Arg Met Lys Met Asp Arg Asp Pro Leu 
        355                 360                 365             


Gly Gly Leu Ala Asp Met Phe Gly Gln Met Pro Gly Ser Gly Ile Gly 
    370                 375                 380                 


Thr Gly Pro Gly Val Ile Gln Asp Arg Phe Ser Pro Thr Met Gly Arg 
385                 390                 395                 400 


His Arg Ser Asn Gln Leu Phe Asn Gly His Gly Gly His Ile Met Pro 
                405                 410                 415     


Pro Thr Gln Ser Gln Phe Gly Glu Met Gly Gly Lys Phe Met Lys Ser 
            420                 425                 430         


Gln Gly Leu Ser Gln Leu Tyr His Asn Gln Ser Gln Gly Leu Leu Ser 
        435                 440                 445             


Gln Leu Gln Gly Gln Ser Lys Asp Met Pro Pro Arg Phe Ser Lys Lys 
    450                 455                 460                 


Gly Gln Leu Asn Ala Asp Glu Ile Ser Leu Arg Pro Ala Gln Ser Phe 
465                 470                 475                 480 


Leu Met Asn Lys Asn Gln Val Pro Lys Leu Gln Pro Gln Ile Thr Met 
                485                 490                 495     


Ile Pro Pro Ser Ala Gln Pro Pro Arg Thr Gln Thr Pro Pro Leu Gly 
            500                 505                 510         


Gln Thr Pro Gln Leu Gly Leu Lys Thr Asn Pro Pro Leu Ile Gln Glu 
        515                 520                 525             


Lys Pro Ala Lys Thr Ser Lys Lys Pro Pro Pro Ser Lys Glu Glu Leu 
    530                 535                 540                 


Leu Lys Leu Thr Glu Thr Val Val Thr Glu Tyr Leu Asn Ser Gly Asn 
545                 550                 555                 560 


Ala Asn Glu Ala Val Asn Gly Val Arg Glu Met Arg Ala Pro Lys His 
                565                 570                 575     


Phe Leu Pro Glu Met Leu Ser Lys Val Ile Ile Leu Ser Leu Asp Arg 
            580                 585                 590         


Ser Asp Glu Asp Lys Glu Lys Ala Ser Ser Leu Ile Ser Leu Leu Lys 
        595                 600                 605             


Gln Glu Gly Ile Ala Thr Ser Asp Asn Phe Met Gln Ala Phe Leu Asn 
    610                 615                 620                 


Val Leu Asp Gln Cys Pro Lys Leu Glu Val Asp Ile Pro Leu Val Lys 
625                 630                 635                 640 


Ser Tyr Leu Ala Gln Phe Ala Ala Arg Ala Ile Ile Ser Glu Leu Val 
                645                 650                 655     


Ser Ile Ser Glu Leu Ala Gln Pro Leu Glu Ser Gly Thr His Phe Pro 
            660                 665                 670         


Leu Phe Leu Leu Cys Leu Gln Gln Leu Ala Lys Leu Gln Asp Arg Glu 
        675                 680                 685             


Trp Leu Thr Glu Leu Phe Gln Gln Ser Lys Val Asn Met Gln Lys Met 
    690                 695                 700                 


Leu Pro Glu Ile Asp Gln Asn Lys Asp Arg Met Leu Glu Ile Leu Glu 
705                 710                 715                 720 


Gly Lys Gly Leu Ser Phe Leu Phe Pro Leu Leu Lys Leu Glu Lys Glu 
                725                 730                 735     


Leu Leu Lys Gln Ile Lys Leu Asp Pro Ser Pro Gln Thr Ile Tyr Lys 
            740                 745                 750         


Trp Ile Lys Asp Asn Ile Ser Pro Lys Leu His Val Asp Lys Gly Phe 
        755                 760                 765             


Val Asn Ile Leu Met Thr Ser Phe Leu Gln Tyr Ile Ser Ser Glu Val 
    770                 775                 780                 


Asn Pro Pro Ser Asp Glu Thr Asp Ser Ser Ser Ala Pro Ser Lys Glu 
785                 790                 795                 800 


Gln Leu Glu Gln Glu Lys Gln Leu Leu Leu Ser Phe Lys Pro Val Met 
                805                 810                 815     


Gln Lys Phe Leu His Asp His Val Asp Leu Gln Val Ser Ala Leu Tyr 
            820                 825                 830         


Ala Leu Gln Val His Cys Tyr Asn Ser Asn Phe Pro Lys Gly Met Leu 
        835                 840                 845             


Leu Arg Phe Phe Val His Phe Tyr Asp Met Glu Ile Ile Glu Glu Glu 
    850                 855                 860                 


Ala Phe Leu Ala Trp Lys Glu Asp Ile Thr Gln Glu Phe Pro Gly Lys 
865                 870                 875                 880 


Gly Lys Ala Leu Phe Gln Val Asn Gln Trp Leu Thr Trp Leu Glu Thr 
                885                 890                 895     


Ala Glu Glu Glu Glu Ser Glu Glu Glu Ala Asp 
            900                 905         


<210>  225
<211>  4125
<212>  DNA
<213>  Homo sapiens

<400>  225
atgagcacgg aggcggacga gggcatcact ttctctgtgc cacccttcgc cccctcgggc       60

ttctgcacca tccccgaggg cggcatctgc aggaggggag gagcggcggc ggtgggcgag      120

ggcgaggagc accagctgcc accgccgccg ccgggcagct tctggaacgt ggagagcgcc      180

gctgcccctg gcatcggttg tccggcggcc acctcctcga gcagtgccac ccgaggccgg      240

ggcagctctg ttggcggggg cagccgacgg accacggtgg catatgtgat caacgaagcg      300

agccaagggc aactggtggt ggccgagagc gaggccctgc agagcttgcg ggaggcgtgc      360

gagacagtgg gcgccaccct ggaaaccctg cattttggga aactcgactt tggagaaacc      420

accgtgctgg accgctttta caatgcagat attgcggtgg tggagatgag cgatgccttc      480

cggcagccgt ccttgtttta ccaccttggg gtgagagaaa gtttcagcat ggccaacaac      540

atcatcctct actgtgatac taactcggac tctctgcagt cactgaagga aataatttgc      600

cagaagaata ctatgtgcac tgggaactac acctttgttc cttacatgat aactccacat      660

aacaaagtct actgctgtga cagcagcttc atgaaggggt tgacagagct catgcaaccg      720

aacttcgagc tgcttcttgg acccatctgc ttacctcttg tggatcgttt tattcaactt      780

ttgaaggtgg cacaagcaag ttctagccag tacttccggg aatctatact caatgacatc      840

aggaaagctc gtaatttata cactggtaaa gaattggcag ctgagttggc aagaattcgg      900

cagcgagtag ataatatcga agtcttgaca gcagatattg tcataaatct gttactttcc      960

tacagagata tccaggacta tgattctatt gtgaagctgg tagagacttt agaaaaactg     1020

ccaacctttg atttggcctc ccatcaccat gtgaagtttc attatgcatt tgcactgaat     1080

aggagaaatc tccctggtga cagagcaaaa gctcttgata ttatgattcc catggtgcaa     1140

agcgaaggac aagttgcttc agatatgtat tgcctagttg gtcgaatcta caaagatatg     1200

tttttggact ctaatttcac ggacactgaa agcagagacc atggagcttc ttggttcaaa     1260

aaggcatttg aatctgagcc aacactacag tcaggaatta attatgcggt cctcctcctg     1320

gcagctggac accagtttga atcttccttt gagctccgga aagttggggt gaagctaagt     1380

agtcttcttg gtaaaaaggg aaacttggaa aaactccaga gctactggga agttggattt     1440

tttctggggg ccagcgtcct agccaatgac cacatgagag tcattcaagc atctgaaaag     1500

ctttttaaac tgaagacacc agcatggtac ctcaagtcta ttgtagagac aattttaata     1560

tataagcatt ttgtgaaact gaccacagaa cagcctgtgg ccaagcaaga acttgtggac     1620

ttttggatgg atttcctggt cgaggccaca aagacagatg ttactgtggt taggtttcca     1680

gtattaatat tagaaccaac caaaatctat caaccttctt atttgtctat caacaatgaa     1740

gttgaggaaa agacaatctc tatttggcac gtgcttcctg atgacaagaa aggtatacat     1800

gagtggaatt ttagtgcctc ttctgtcagg ggagtgagta tttctaaatt tgaagaaaga     1860

tgctgctttc tttatgtgct tcacaattct gatgatttcc aaatctattt ctgtacagaa     1920

cttcattgta aaaagttttt tgagatggtg aacaccatta ccgaagagaa ggggagaagc     1980

acagaggaag gagactgtga aagtgacttg ctggagtatg actatgaata tgatgaaaat     2040

ggtgacagag tcgttttagg aaaaggcact tatgggatag tctacgcagg tcgggacttg     2100

agcaaccaag tcagaattgc tattaaggaa atcccagaga gagacagcag atactctcag     2160

cccctgcatg aagaaatagc attgcataaa cacctgaagc acaaaaatat tgtccagtat     2220

ctgggctctt tcagtgagaa tggtttcatt aaaatcttca tggagcaggt ccctggagga     2280

agtctttctg ctctccttcg ttccaaatgg ggtccattaa aagacaatga gcaaacaatt     2340

ggcttttata caaagcaaat actggaagga ttaaaatatc tccatgacaa tcagatagtt     2400

caccgggaca taaagggtga caatgtgttg attaatacct acagtggtgt tctcaagatc     2460

tctgacttcg gaacatcaaa gaggcttgct ggcataaacc cctgtactga aacttttact     2520

ggtaccctcc agtatatggc accagaaata atagataaag gaccaagagg ctacggaaaa     2580

gcagcagaca tctggtctct gggctgtaca atcattgaaa tggccacagg aaaaccccca     2640

ttttatgaac tgggagaacc acaagcagct atgttcaagg tgggaatgtt taaagtccac     2700

cctgagatcc cagagtccat gtctgcagag gccaaggcat tcatactgaa atgttttgaa     2760

ccagatcctg acaagagagc ctgtgctaac gacttgcttg ttgatgagtt tttaaaagtt     2820

tcaagcaaaa agaaaaagac acaacctaag ctttcagctc tttcagctgg atcaaatgaa     2880

tatctcagga gtatatcctt gccggtacct gtgctggtgg aggacaccag cagcagcagt     2940

gagtacggct cagtttcacc cgacacggag ttgaaagtgg accccttctc tttcaaaaca     3000

agagccaagt cctgcggaga aagagatgtc aagggaattc ggacactctt tttgggcatt     3060

ccagatgaga attttgaaga tcacagtgct cctccttccc ctgaagaaaa agattctgga     3120

ttcttcatgc tgaggaagga cagtgagagg cgagctaccc ttcacaggat cctgacggaa     3180

gaccaagaca aaattgtgag aaacctaatg gaatctttag ctcagggggc tgaagaaccg     3240

aaactaaaat gggaacacat cacaaccctc attgcaagcc tcagagaatt tgtgagatcc     3300

actgaccgaa aaatcatagc caccacactg tcaaagctga aactggagct ggacttcgac     3360

agccatggca ttagccaagt ccaggtggta ctctttggtt ttcaagatgc tgtcaataaa     3420

gttcttcgga atcataacat caagccgcac tggatgtttg ccttagacag tatcattcgg     3480

aaggcggtac agacagccat taccatcctg gttccagaac taaggccaca tttcagcctt     3540

gcatctgaga gtgatactgc tgatcaagaa gacttggatg tagaagatga ccatgaggaa     3600

cagccttcaa atcaaactgt ccgaagacct caggctgtca ttgaagatgc tgtggctacc     3660

tcaggcgtga gcacgctcag ttctactgtg tctcatgatt cccagagtgc tcaccggtca     3720

ctgaatgtac agcttggaag gatgaaaata gaaaccaata gattactgga agaattggtt     3780

cggaaagaga aagaattaca agcactcctt catcgagcta ttgaagaaaa agaccaagaa     3840

attaaacacc tgaagcttaa gtcccaaccc atagaaattc ctgaattgcc tgtatttcat     3900

ctaaattctt ctggcacaaa tactgaagat tctgaactta ccgactggct gagagtgaat     3960

ggagctgatg aagacactat aagccggttt ttggctgaag attatacact attggatgtt     4020

ctctactatg ttacacgtga tgacttaaaa tgcttgagac taaggggagg gatgctgtgc     4080

acactgtgga aggctatcat tgactttcga aacaaacaga cttga                     4125


<210>  226
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ser Thr Glu Ala Asp Glu Gly Ile Thr Phe Ser Val Pro Pro Phe 
1               5                   10                  15      


Ala Pro Ser Gly Phe Cys Thr Ile Pro Glu Gly Gly Ile Cys Arg Arg 
            20                  25                  30          


Gly Gly Ala Ala Ala Val Gly Glu Gly Glu Glu His Gln Leu Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly Ser Phe Trp Asn Val Glu Ser Ala Ala Ala Pro Gly 
    50                  55                  60                  


Ile Gly Cys Pro Ala Ala Thr Ser Ser Ser Ser Ala Thr Arg Gly Arg 
65                  70                  75                  80  


Gly Ser Ser Val Gly Gly Gly Ser Arg Arg Thr Thr Val Ala Tyr Val 
                85                  90                  95      


Ile Asn Glu Ala Ser Gln Gly Gln Leu Val Val Ala Glu Ser Glu Ala 
            100                 105                 110         


Leu Gln Ser Leu Arg Glu Ala Cys Glu Thr Val Gly Ala Thr Leu Glu 
        115                 120                 125             


Thr Leu His Phe Gly Lys Leu Asp Phe Gly Glu Thr Thr Val Leu Asp 
    130                 135                 140                 


Arg Phe Tyr Asn Ala Asp Ile Ala Val Val Glu Met Ser Asp Ala Phe 
145                 150                 155                 160 


Arg Gln Pro Ser Leu Phe Tyr His Leu Gly Val Arg Glu Ser Phe Ser 
                165                 170                 175     


Met Ala Asn Asn Ile Ile Leu Tyr Cys Asp Thr Asn Ser Asp Ser Leu 
            180                 185                 190         


Gln Ser Leu Lys Glu Ile Ile Cys Gln Lys Asn Thr Met Cys Thr Gly 
        195                 200                 205             


Asn Tyr Thr Phe Val Pro Tyr Met Ile Thr Pro His Asn Lys Val Tyr 
    210                 215                 220                 


Cys Cys Asp Ser Ser Phe Met Lys Gly Leu Thr Glu Leu Met Gln Pro 
225                 230                 235                 240 


Asn Phe Glu Leu Leu Leu Gly Pro Ile Cys Leu Pro Leu Val Asp Arg 
                245                 250                 255     


Phe Ile Gln Leu Leu Lys Val Ala Gln Ala Ser Ser Ser Gln Tyr Phe 
            260                 265                 270         


Arg Glu Ser Ile Leu Asn Asp Ile Arg Lys Ala Arg Asn Leu Tyr Thr 
        275                 280                 285             


Gly Lys Glu Leu Ala Ala Glu Leu Ala Arg Ile Arg Gln Arg Val Asp 
    290                 295                 300                 


Asn Ile Glu Val Leu Thr Ala Asp Ile Val Ile Asn Leu Leu Leu Ser 
305                 310                 315                 320 


Tyr Arg Asp Ile Gln Asp Tyr Asp Ser Ile Val Lys Leu Val Glu Thr 
                325                 330                 335     


Leu Glu Lys Leu Pro Thr Phe Asp Leu Ala Ser His His His Val Lys 
            340                 345                 350         


Phe His Tyr Ala Phe Ala Leu Asn Arg Arg Asn Leu Pro Gly Asp Arg 
        355                 360                 365             


Ala Lys Ala Leu Asp Ile Met Ile Pro Met Val Gln Ser Glu Gly Gln 
    370                 375                 380                 


Val Ala Ser Asp Met Tyr Cys Leu Val Gly Arg Ile Tyr Lys Asp Met 
385                 390                 395                 400 


Phe Leu Asp Ser Asn Phe Thr Asp Thr Glu Ser Arg Asp His Gly Ala 
                405                 410                 415     


Ser Trp Phe Lys Lys Ala Phe Glu Ser Glu Pro Thr Leu Gln Ser Gly 
            420                 425                 430         


Ile Asn Tyr Ala Val Leu Leu Leu Ala Ala Gly His Gln Phe Glu Ser 
        435                 440                 445             


Ser Phe Glu Leu Arg Lys Val Gly Val Lys Leu Ser Ser Leu Leu Gly 
    450                 455                 460                 


Lys Lys Gly Asn Leu Glu Lys Leu Gln Ser Tyr Trp Glu Val Gly Phe 
465                 470                 475                 480 


Phe Leu Gly Ala Ser Val Leu Ala Asn Asp His Met Arg Val Ile Gln 
                485                 490                 495     


Ala Ser Glu Lys Leu Phe Lys Leu Lys Thr Pro Ala Trp Tyr Leu Lys 
            500                 505                 510         


Ser Ile Val Glu Thr Ile Leu Ile Tyr Lys His Phe Val Lys Leu Thr 
        515                 520                 525             


Thr Glu Gln Pro Val Ala Lys Gln Glu Leu Val Asp Phe Trp Met Asp 
    530                 535                 540                 


Phe Leu Val Glu Ala Thr Lys Thr Asp Val Thr Val Val Arg Phe Pro 
545                 550                 555                 560 


Val Leu Ile Leu Glu Pro Thr Lys Ile Tyr Gln Pro Ser Tyr Leu Ser 
                565                 570                 575     


Ile Asn Asn Glu Val Glu Glu Lys Thr Ile Ser Ile Trp His Val Leu 
            580                 585                 590         


Pro Asp Asp Lys Lys Gly Ile His Glu Trp Asn Phe Ser Ala Ser Ser 
        595                 600                 605             


Val Arg Gly Val Ser Ile Ser Lys Phe Glu Glu Arg Cys Cys Phe Leu 
    610                 615                 620                 


Tyr Val Leu His Asn Ser Asp Asp Phe Gln Ile Tyr Phe Cys Thr Glu 
625                 630                 635                 640 


Leu His Cys Lys Lys Phe Phe Glu Met Val Asn Thr Ile Thr Glu Glu 
                645                 650                 655     


Lys Gly Arg Ser Thr Glu Glu Gly Asp Cys Glu Ser Asp Leu Leu Glu 
            660                 665                 670         


Tyr Asp Tyr Glu Tyr Asp Glu Asn Gly Asp Arg Val Val Leu Gly Lys 
        675                 680                 685             


Gly Thr Tyr Gly Ile Val Tyr Ala Gly Arg Asp Leu Ser Asn Gln Val 
    690                 695                 700                 


Arg Ile Ala Ile Lys Glu Ile Pro Glu Arg Asp Ser Arg Tyr Ser Gln 
705                 710                 715                 720 


Pro Leu His Glu Glu Ile Ala Leu His Lys His Leu Lys His Lys Asn 
                725                 730                 735     


Ile Val Gln Tyr Leu Gly Ser Phe Ser Glu Asn Gly Phe Ile Lys Ile 
            740                 745                 750         


Phe Met Glu Gln Val Pro Gly Gly Ser Leu Ser Ala Leu Leu Arg Ser 
        755                 760                 765             


Lys Trp Gly Pro Leu Lys Asp Asn Glu Gln Thr Ile Gly Phe Tyr Thr 
    770                 775                 780                 


Lys Gln Ile Leu Glu Gly Leu Lys Tyr Leu His Asp Asn Gln Ile Val 
785                 790                 795                 800 


His Arg Asp Ile Lys Gly Asp Asn Val Leu Ile Asn Thr Tyr Ser Gly 
                805                 810                 815     


Val Leu Lys Ile Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala Gly Ile 
            820                 825                 830         


Asn Pro Cys Thr Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met Ala Pro 
        835                 840                 845             


Glu Ile Ile Asp Lys Gly Pro Arg Gly Tyr Gly Lys Ala Ala Asp Ile 
    850                 855                 860                 


Trp Ser Leu Gly Cys Thr Ile Ile Glu Met Ala Thr Gly Lys Pro Pro 
865                 870                 875                 880 


Phe Tyr Glu Leu Gly Glu Pro Gln Ala Ala Met Phe Lys Val Gly Met 
                885                 890                 895     


Phe Lys Val His Pro Glu Ile Pro Glu Ser Met Ser Ala Glu Ala Lys 
            900                 905                 910         


Ala Phe Ile Leu Lys Cys Phe Glu Pro Asp Pro Asp Lys Arg Ala Cys 
        915                 920                 925             


Ala Asn Asp Leu Leu Val Asp Glu Phe Leu Lys Val Ser Ser Lys Lys 
    930                 935                 940                 


Lys Lys Thr Gln Pro Lys Leu Ser Ala Leu Ser Ala Gly Ser Asn Glu 
945                 950                 955                 960 


Tyr Leu Arg Ser Ile Ser Leu Pro Val Pro Val Leu Val Glu Asp Thr 
                965                 970                 975     


Ser Ser Ser Ser Glu Tyr Gly Ser Val Ser Pro Asp Thr Glu Leu Lys 
            980                 985                 990         


Val Asp Pro Phe Ser Phe Lys Thr  Arg Ala Lys Ser Cys  Gly Glu Arg 
        995                 1000                 1005             


Asp Val  Lys Gly Ile Arg Thr  Leu Phe Leu Gly Ile  Pro Asp Glu 
    1010                 1015                 1020             


Asn Phe  Glu Asp His Ser Ala  Pro Pro Ser Pro Glu  Glu Lys Asp 
    1025                 1030                 1035             


Ser Gly  Phe Phe Met Leu Arg  Lys Asp Ser Glu Arg  Arg Ala Thr 
    1040                 1045                 1050             


Leu His  Arg Ile Leu Thr Glu  Asp Gln Asp Lys Ile  Val Arg Asn 
    1055                 1060                 1065             


Leu Met  Glu Ser Leu Ala Gln  Gly Ala Glu Glu Pro  Lys Leu Lys 
    1070                 1075                 1080             


Trp Glu  His Ile Thr Thr Leu  Ile Ala Ser Leu Arg  Glu Phe Val 
    1085                 1090                 1095             


Arg Ser  Thr Asp Arg Lys Ile  Ile Ala Thr Thr Leu  Ser Lys Leu 
    1100                 1105                 1110             


Lys Leu  Glu Leu Asp Phe Asp  Ser His Gly Ile Ser  Gln Val Gln 
    1115                 1120                 1125             


Val Val  Leu Phe Gly Phe Gln  Asp Ala Val Asn Lys  Val Leu Arg 
    1130                 1135                 1140             


Asn His  Asn Ile Lys Pro His  Trp Met Phe Ala Leu  Asp Ser Ile 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Gln Thr  Ala Ile Thr Ile Leu  Val Pro Glu 
    1160                 1165                 1170             


Leu Arg  Pro His Phe Ser Leu  Ala Ser Glu Ser Asp  Thr Ala Asp 
    1175                 1180                 1185             


Gln Glu  Asp Leu Asp Val Glu  Asp Asp His Glu Glu  Gln Pro Ser 
    1190                 1195                 1200             


Asn Gln  Thr Val Arg Arg Pro  Gln Ala Val Ile Glu  Asp Ala Val 
    1205                 1210                 1215             


Ala Thr  Ser Gly Val Ser Thr  Leu Ser Ser Thr Val  Ser His Asp 
    1220                 1225                 1230             


Ser Gln  Ser Ala His Arg Ser  Leu Asn Val Gln Leu  Gly Arg Met 
    1235                 1240                 1245             


Lys Ile  Glu Thr Asn Arg Leu  Leu Glu Glu Leu Val  Arg Lys Glu 
    1250                 1255                 1260             


Lys Glu  Leu Gln Ala Leu Leu  His Arg Ala Ile Glu  Glu Lys Asp 
    1265                 1270                 1275             


Gln Glu  Ile Lys His Leu Lys  Leu Lys Ser Gln Pro  Ile Glu Ile 
    1280                 1285                 1290             


Pro Glu  Leu Pro Val Phe His  Leu Asn Ser Ser Gly  Thr Asn Thr 
    1295                 1300                 1305             


Glu Asp  Ser Glu Leu Thr Asp  Trp Leu Arg Val Asn  Gly Ala Asp 
    1310                 1315                 1320             


Glu Asp  Thr Ile Ser Arg Phe  Leu Ala Glu Asp Tyr  Thr Leu Leu 
    1325                 1330                 1335             


Asp Val  Leu Tyr Tyr Val Thr  Arg Asp Asp Leu Lys  Cys Leu Arg 
    1340                 1345                 1350             


Leu Arg  Gly Gly Met Leu Cys  Thr Leu Trp Lys Ala  Ile Ile Asp 
    1355                 1360                 1365             


Phe Arg  Asn Lys Gln Thr 
    1370                 


<210>  227
<211>  5396
<212>  DNA
<213>  Homo sapiens

<400>  227
gtgctgtggc ccaatcctgt gcgtgtctcc tcttcaggct cctgccggag catgcttctc       60

taatcttacc atttatcact gacccttcgg tgaaactctc ttctgtttaa atttaccagg      120

gtacactttg taatacttgg gaccaagaat ttgaagatag taatcagaca aatcaaacaa      180

ctagtagtag tggagagaca cgtagcccta caggaagggg tagaattatc attaaaaaca      240

cagacaaacc agagactgcc tgaaaaaaaa aaaaagatga actggaaaga ttcaaagtag      300

gctctattgg aggtggctgc ctctttgatg agccgtatag cacatgtgga tatagtcaat      360

ctgaaggtga tgacttcaat tgggagcaag tgaacacctt gactaaaccg acttctgatc      420

catggatgcc atcaggttct ttcatgctgg tgaatgcctc tgggagacct gaggggcaga      480

gagcccacct gctcttaccc caacttaaag aaaatgacac ccactgcatc gattttcact      540

attttgtgtc cagcaagagt aattctcctc cggggttact caatgtctac gtgaaggtca      600

ataacgggcc actggggaat cctatctgga atatatctgg agacccagca cgtacatgga      660

acagggcaga actggccatt agtactttct ggcctaactt ttatcaggtg atttttgaag      720

tgataacttc tggacatcaa ggctatctcg ctatcgatga ggtgaaggtg ttaggacatc      780

catgtaccag gactcctcac ttcctgcgga ttcagaatgt ggaagttaat gctggccagt      840

ttgctacctt ccagtgcagt gccatcggca ggaccgtggc aggagacagg ctctggttac      900

agggcattga tgtgcgagat gctcctctga aggaaatcaa ggtgaccagc tcccgacgct      960

tcattgcttc atttaatgtt gtgaatacca ccaaacgaga tgctggaaag taccgctgca     1020

tgattcgcac tgaaggaggt gttggaatat caaactatgc agagttggta gttaaagaac     1080

cacccgttcc tattgcccca cctcagctcg cctctgtagg agccacctac ctgtggatac     1140

agctcaacgc caactccatc aatggggatg ggcccattgt ggcccgagag gtggagtact     1200

gcacggccag tgggagctgg aatgaccggc agccagtcga ttccacgagc tataaaattg     1260

gacaccttga cccagataca gaatatgaga ttagtgtgct cctgaccagg ccaggggagg     1320

gtggcactgg ctctcctggt ccagctctca ggacaagaac aaagtgtgct gatcccatgc     1380

gaggcccaag aaaactagaa gtagtggagg tcaaatctcg gcaaatcact atcagctggg     1440

agccatttgg atataatgta actcgttgcc acagttataa tctcactgtc cactactgtt     1500

accaagttgg aggacaagaa caagtgcgag aagaagtaag ctgggataca gaaaactcac     1560

accctcaaca cacgatcact aacctgtcac catacaccaa tgtcagtgtg aaactgatcc     1620

tcatgaaccc agagggccgg aaggaaagcc aagaactcat agtgcagaca gatgaagacc     1680

tcccaggtgc tgttcccact gaatccatac aaggaagtac ctttgaagag aagatatttc     1740

ttcagtggag agaaccaact caaacatatg gtgtaatcac tttatatgag atcacctaca     1800

aagcagtcag ttcctttgac ccagaaatag atttatccaa tcagagtgga agagtttcaa     1860

agctgggaaa tgaaacccat ttcctgtttt ttggactgta tccggggacc acatactcct     1920

ttaccatccg agctagcaca gctaagggtt ttgggcctcc agcaacaaac cagttcacca     1980

ccaaaatatc agcaccctct atgccagctt atgaacttga gacacctttg aatcaaactg     2040

acaataccgt gacagtcatg ctgaaacctg cccacagcag aggagcacct gtcagtgtct     2100

atcaaatagt tgttgaggaa gaacgtcctc gaagaactaa aaagacgaca gaaatcttaa     2160

agtgctaccc agtgccaatt cacttccaga atgcttctct gctgaactca cagtactact     2220

ttgctgcaga atttcctgca gacagcctcc aagctgcgca gccttttaca attggtgata     2280

ataagacata taatggatac tggaacactc cccttctccc ctataaaagc tacagaattt     2340

atttccaagc tgctagtaga gccaatgggg aaaccaaaat agactgtgtc caagtggcca     2400

caaaaggagc tgccactccg aaaccagtcc cagaacccga gaaacagaca gaccatacag     2460

ttaaaattgc tggagtcatc gcgggcatct tgctgttcgt gattatattt cttggagttg     2520

tgttggtaat gaagaaaagg aaactggcca agaagcggaa agagaccatg agcagcaccc     2580

gacaggagat gactgtgatg gtgaactcaa tggacaagag ctatgctgag cagggcacaa     2640

actgcgacga ggctttctca ttcatggaca cgcacaatct gaatgggaga tctgtgtctt     2700

caccatcgtc cttcacaatg aaaacaaata cactgagcac atcggtgcct aattcctatt     2760

acccagatga aacccacaca atggccagcg ataccagcag cctggtgcag tcccatactt     2820

acaagaagcg agagccggcc gacgtgccct atcagactgg gcagctccac cccgccatcc     2880

gggtggcaga cctccttcag cacatcacac agatgaagtg tgcggagggc tacggcttca     2940

aggaggaata cgagagcttc tttgaagggc agtctgcacc atgggactcg gctaagaaag     3000

gtgagaacag aatgaagaac agatacggga atatcattgc atacgatcat tcccgagtga     3060

ggctgcagac aatagaagga gacacaaact cagactatat caatggcaat tatatcgatg     3120

gttatcatcg acccaatcat tacattgcta cccaagggcc aatgcaggaa accatctatg     3180

acttctggag gatggtgtgg cacgaaaaca ctgcaagtat catcatggtg accaatcttg     3240

tggaagtggg aagggtcaaa tgctgcaaat actggccaga tgacacagag atatataaag     3300

acattaaagt taccctaata gaaacagaac tactggcaga atatgtgata agaacatttg     3360

ctgttgaaaa gagaggtgtg catgaaatcc gagagatcag acagtttcac ttcactggct     3420

ggccggatcg tggggtcccc taccatgcca ccggcctgct gggattcgtg cggcaagtca     3480

agtccaagag cccgcccagt gcaggcccac tggtggtgca ctgcagtgct ggtgcaggga     3540

ggactggctg tttcatcgtc attgatatca tgttggacat ggccgaaagg gaaggggtcg     3600

tagacatcta caactgcgtc agggagctgc ggtcacggag ggtgaacatg gtgcaaacag     3660

aggagcagta tgtgtttatc cacgatgcga tcctggaagc ctgtctttgt ggggacacct     3720

ctgtgcctgc ttcccaagtt aggtctctgt attatgacat gaacaaactg gatccacaga     3780

caaactcaag ccagattaaa gaggaattcc ggacgctaaa catggtgaca ccaacgctgc     3840

gagtagagga ctgcagcatc gcactgttgc cccggaacca tgagaaaaac cggtgcatgg     3900

acatcctgcc cccagaccgc tgcctgccct tcctcatcac catcgatggg gagagcagca     3960

actacatcaa tgctgccctc atggacagct ataaacagcc ttcagctttt atagtcaccc     4020

agcatccttt gccaaacaca gtgaaagact tttggagact ggtcctggat tatcactgca     4080

catccgtagt tatgctaaat gatgtggatc ctgcccagtt gtgtccacag tactggccag     4140

aaaacggagt acacagacac ggccccatcc aggtggaatt tgtctctgct gacctggaag     4200

aggacatcat cagcaggata ttccgcattt acaatgccgc cagaccccaa gatggatatc     4260

ggatggtgca gcaattccag ttcctgggct ggccgatgta cagggacaca ccagtgtcta     4320

agcgctcctt cttgaagctc attcgccagg tggacaagtg gcaagaggaa tacaatggcg     4380

gggaaggccg caccgttgtg cactgcttga acgggggagg ccgcagtggg acgttctgcg     4440

ccatcagcat cgtatgtgag atgctccggc accagagaac cgtggatgtc tttcacgctg     4500

tgaagacact gaggaacaac aagcccaaca tggtcgacct cctggatcag tacaagttct     4560

gctacgaggt ggccctggaa tacttgaatt ctggctgatg gtgtaaacag ctctgcaaac     4620

aatccctttc ataccacaaa gccaagacgt tccatggtat ttgtgcaaaa gagatgaaga     4680

cttctcaata tgcttatttt gctttgcata attggctctt tttaagagcc caagaaagtg     4740

tttctaaaat tgcttgcact gcccaatccc agtaatgctg ctgcctgaca gaaacacaca     4800

cacagccaca gttgccaaat cccgtactcc ttgccaccag cttcctagag cagcgtagac     4860

agctggtaaa ctgaagagca caactatatt cttatgaagg aatttgtacc tttggggtat     4920

tattttgtgg cccgtgaccc tcgttattgt tacagctgag tgtatgtttt tgttctgtgg     4980

agaatgctat ctggcattat ggtaatatat tattttaggt aatatttgta ctttaacatg     5040

ttgcataata tatgcttatg tagctttcca ggactaacag ataaatgtgt aatgaacaaa     5100

gatatgttgt atgagtcgtc gtttctgtca gatttgtatt gtttccaagg gaaaagcttg     5160

ggggaggact cagttcacaa aatgcaaaac tcaacgatca gattcacgga cccagagctt     5220

ttccatgtgt ttatattgta aatatttttg atttcatcaa attatttatt cattaaaaga     5280

aatttttgcg aaaaaaaaaa aaaaaactct ccagcgctgg atccggccat aagggcctga     5340

tccagcgctg gagagttttt tttttttttt tcttgaaatg tcaattactg ctatgc         5396


<210>  228
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Pro Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu 
1               5                   10                  15      


Gly Gln Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr 
            20                  25                  30          


His Cys Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro 
        35                  40                  45              


Pro Gly Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly 
    50                  55                  60                  


Asn Pro Ile Trp Asn Ile Ser Gly Asp Pro Ala Arg Thr Trp Asn Arg 
65                  70                  75                  80  


Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile 
                85                  90                  95      


Phe Glu Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu 
            100                 105                 110         


Val Lys Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg 
        115                 120                 125             


Ile Gln Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys 
    130                 135                 140                 


Ser Ala Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly 
145                 150                 155                 160 


Ile Asp Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser 
                165                 170                 175     


Arg Arg Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp 
            180                 185                 190         


Ala Gly Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile 
        195                 200                 205             


Ser Asn Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala 
    210                 215                 220                 


Pro Pro Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu 
225                 230                 235                 240 


Asn Ala Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val 
                245                 250                 255     


Glu Tyr Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp 
            260                 265                 270         


Ser Thr Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu 
        275                 280                 285             


Ile Ser Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro 
    290                 295                 300                 


Gly Pro Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly 
305                 310                 315                 320 


Pro Arg Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile 
                325                 330                 335     


Ser Trp Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn 
            340                 345                 350         


Leu Thr Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg 
        355                 360                 365             


Glu Glu Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile 
    370                 375                 380                 


Thr Asn Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met 
385                 390                 395                 400 


Asn Pro Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp 
                405                 410                 415     


Glu Asp Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr 
            420                 425                 430         


Phe Glu Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr 
        435                 440                 445             


Gly Val Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe 
    450                 455                 460                 


Asp Pro Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu 
465                 470                 475                 480 


Gly Asn Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr 
                485                 490                 495     


Tyr Ser Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro 
            500                 505                 510         


Ala Thr Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala 
        515                 520                 525             


Tyr Glu Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val 
    530                 535                 540                 


Met Leu Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln 
545                 550                 555                 560 


Ile Val Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu 
                565                 570                 575     


Ile Leu Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu 
            580                 585                 590         


Leu Asn Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu 
        595                 600                 605             


Gln Ala Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly 
    610                 615                 620                 


Tyr Trp Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe 
625                 630                 635                 640 


Gln Ala Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln 
                645                 650                 655     


Val Ala Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu 
            660                 665                 670         


Lys Gln Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile 
        675                 680                 685             


Leu Leu Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys 
    690                 695                 700                 


Arg Lys Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln 
705                 710                 715                 720 


Glu Met Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln 
                725                 730                 735     


Gly Thr Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu 
            740                 745                 750         


Asn Gly Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn 
        755                 760                 765             


Thr Leu Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Glu Thr His 
    770                 775                 780                 


Thr Met Ala Ser Asp Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys 
785                 790                 795                 800 


Lys Arg Glu Pro Ala Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro 
                805                 810                 815     


Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys 
            820                 825                 830         


Ala Glu Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly 
        835                 840                 845             


Gln Ser Ala Pro Trp Asp Ser Ala Lys Lys Gly Glu Asn Arg Met Lys 
    850                 855                 860                 


Asn Arg Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu 
865                 870                 875                 880 


Gln Thr Ile Glu Gly Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr 
                885                 890                 895     


Ile Asp Gly Tyr His Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro 
            900                 905                 910         


Met Gln Glu Thr Ile Tyr Asp Phe Trp Arg Met Val Trp His Glu Asn 
        915                 920                 925             


Thr Ala Ser Ile Ile Met Val Thr Asn Leu Val Glu Val Gly Arg Val 
    930                 935                 940                 


Lys Cys Cys Lys Tyr Trp Pro Asp Asp Thr Glu Ile Tyr Lys Asp Ile 
945                 950                 955                 960 


Lys Val Thr Leu Ile Glu Thr Glu Leu Leu Ala Glu Tyr Val Ile Arg 
                965                 970                 975     


Thr Phe Ala Val Glu Lys Arg Gly Val His Glu Ile Arg Glu Ile Arg 
            980                 985                 990         


Gln Phe His Phe Thr Gly Trp Pro  Asp Arg Gly Val Pro  Tyr His Ala 
        995                 1000                 1005             


Thr Gly  Leu Leu Gly Phe Val  Arg Gln Val Lys Ser  Lys Ser Pro 
    1010                 1015                 1020             


Pro Ser  Ala Gly Pro Leu Val  Val His Cys Ser Ala  Gly Ala Gly 
    1025                 1030                 1035             


Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ile Met Leu  Asp Met Ala 
    1040                 1045                 1050             


Glu Arg  Glu Gly Val Val Asp  Ile Tyr Asn Cys Val  Arg Glu Leu 
    1055                 1060                 1065             


Arg Ser  Arg Arg Val Asn Met  Val Gln Thr Glu Glu  Gln Tyr Val 
    1070                 1075                 1080             


Phe Ile  His Asp Ala Ile Leu  Glu Ala Cys Leu Cys  Gly Asp Thr 
    1085                 1090                 1095             


Ser Val  Pro Ala Ser Gln Val  Arg Ser Leu Tyr Tyr  Asp Met Asn 
    1100                 1105                 1110             


Lys Leu  Asp Pro Gln Thr Asn  Ser Ser Gln Ile Lys  Glu Glu Phe 
    1115                 1120                 1125             


Arg Thr  Leu Asn Met Val Thr  Pro Thr Leu Arg Val  Glu Asp Cys 
    1130                 1135                 1140             


Ser Ile  Ala Leu Leu Pro Arg  Asn His Glu Lys Asn  Arg Cys Met 
    1145                 1150                 1155             


Asp Ile  Leu Pro Pro Asp Arg  Cys Leu Pro Phe Leu  Ile Thr Ile 
    1160                 1165                 1170             


Asp Gly  Glu Ser Ser Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser 
    1175                 1180                 1185             


Tyr Lys  Gln Pro Ser Ala Phe  Ile Val Thr Gln His  Pro Leu Pro 
    1190                 1195                 1200             


Asn Thr  Val Lys Asp Phe Trp  Arg Leu Val Leu Asp  Tyr His Cys 
    1205                 1210                 1215             


Thr Ser  Val Val Met Leu Asn  Asp Val Asp Pro Ala  Gln Leu Cys 
    1220                 1225                 1230             


Pro Gln  Tyr Trp Pro Glu Asn  Gly Val His Arg His  Gly Pro Ile 
    1235                 1240                 1245             


Gln Val  Glu Phe Val Ser Ala  Asp Leu Glu Glu Asp  Ile Ile Ser 
    1250                 1255                 1260             


Arg Ile  Phe Arg Ile Tyr Asn  Ala Ala Arg Pro Gln  Asp Gly Tyr 
    1265                 1270                 1275             


Arg Met  Val Gln Gln Phe Gln  Phe Leu Gly Trp Pro  Met Tyr Arg 
    1280                 1285                 1290             


Asp Thr  Pro Val Ser Lys Arg  Ser Phe Leu Lys Leu  Ile Arg Gln 
    1295                 1300                 1305             


Val Asp  Lys Trp Gln Glu Glu  Tyr Asn Gly Gly Glu  Gly Arg Thr 
    1310                 1315                 1320             


Val Val  His Cys Leu Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys 
    1325                 1330                 1335             


Ala Ile  Ser Ile Val Cys Glu  Met Leu Arg His Gln  Arg Thr Val 
    1340                 1345                 1350             


Asp Val  Phe His Ala Val Lys  Thr Leu Arg Asn Asn  Lys Pro Asn 
    1355                 1360                 1365             


Met Val  Asp Leu Leu Asp Gln  Tyr Lys Phe Cys Tyr  Glu Val Ala 
    1370                 1375                 1380             


Leu Glu  Tyr Leu Asn Ser Gly  
    1385                 1390 


<210>  229
<211>  1203
<212>  DNA
<213>  Homo sapiens

<400>  229
atgcctttat caatgcgtta cctcttcata atttctgtct ctagtgtaat tatttttatc       60

gtcttctctg tgttcaattt tgggggagat ccaagcttcc aaaggctaaa tatctcagac      120

cctttgaggc tgactcaagt ttgcacatct tttatcaatg gaaaaacacg tttcctgtgg      180

aaaaacaaac taatgatcca tgagaagtct tcttgcaagg aatacttgac ccagagccac      240

tacatcacag cccctttatc taaggaagaa gctgactttc ccttggcata tataatggtc      300

atccatcatc actttgacac ctttgcaagg ctcttcaggg ctatttacat gccccaaaat      360

atctactgtg ttcatgtgga tgaaaaagca acaactgaat ttaaagatgc ggtagagcaa      420

ctattaagct gcttcccaaa cgcttttctg gcttccaaga tggaacccgt tgtctatgga      480

gggatctcca ggctccaggc tgacctgaac tgcatcagag atctttctgc cttcgaggtc      540

tcatggaagt acgttatcaa cacctgtggg caagacttcc ccctgaaaac caacaaggaa      600

atagttcagt atctgaaagg atttaaaggt aaaaatatca ccccaggggt gctgccccca      660

gctcatgcaa ttggacggac taaatatgtc caccaagagc acctgggcaa agagctttcc      720

tatgtgataa gaacaacagc gttgaaaccg cctccccccc ataatctcac aatttacttt      780

ggctctgcct atgtggctct atcaagagag tttgccaact ttgttctgca tgacccacgg      840

gctgttgatt tgctccagtg gtccaaggac actttcagtc ctgatgagca tttctgggtg      900

acactcaata ggattccagg tgttcctggc tctatgccaa atgcatcctg gactggaaac      960

ctcagagcta taaagtggag tgacatggaa gacagacacg gaggctgcca cggccactat     1020

gtacatggta tttgtatcta tggaaacgga gacttaaagt ggctggttaa ttcaccaagc     1080

ctgtttgcta acaagtttga gcttaatacc taccccctta ctgtggaatg cctagaactg     1140

aggcatcgcg aaagaaccct caatcagagt gaaactgcga tacaacccag ctggtatttt     1200

tga                                                                   1203


<210>  230
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Pro Leu Ser Met Arg Tyr Leu Phe Ile Ile Ser Val Ser Ser Val 
1               5                   10                  15      


Ile Ile Phe Ile Val Phe Ser Val Phe Asn Phe Gly Gly Asp Pro Ser 
            20                  25                  30          


Phe Gln Arg Leu Asn Ile Ser Asp Pro Leu Arg Leu Thr Gln Val Cys 
        35                  40                  45              


Thr Ser Phe Ile Asn Gly Lys Thr Arg Phe Leu Trp Lys Asn Lys Leu 
    50                  55                  60                  


Met Ile His Glu Lys Ser Ser Cys Lys Glu Tyr Leu Thr Gln Ser His 
65                  70                  75                  80  


Tyr Ile Thr Ala Pro Leu Ser Lys Glu Glu Ala Asp Phe Pro Leu Ala 
                85                  90                  95      


Tyr Ile Met Val Ile His His His Phe Asp Thr Phe Ala Arg Leu Phe 
            100                 105                 110         


Arg Ala Ile Tyr Met Pro Gln Asn Ile Tyr Cys Val His Val Asp Glu 
        115                 120                 125             


Lys Ala Thr Thr Glu Phe Lys Asp Ala Val Glu Gln Leu Leu Ser Cys 
    130                 135                 140                 


Phe Pro Asn Ala Phe Leu Ala Ser Lys Met Glu Pro Val Val Tyr Gly 
145                 150                 155                 160 


Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Ile Arg Asp Leu Ser 
                165                 170                 175     


Ala Phe Glu Val Ser Trp Lys Tyr Val Ile Asn Thr Cys Gly Gln Asp 
            180                 185                 190         


Phe Pro Leu Lys Thr Asn Lys Glu Ile Val Gln Tyr Leu Lys Gly Phe 
        195                 200                 205             


Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Ala His Ala Ile 
    210                 215                 220                 


Gly Arg Thr Lys Tyr Val His Gln Glu His Leu Gly Lys Glu Leu Ser 
225                 230                 235                 240 


Tyr Val Ile Arg Thr Thr Ala Leu Lys Pro Pro Pro Pro His Asn Leu 
                245                 250                 255     


Thr Ile Tyr Phe Gly Ser Ala Tyr Val Ala Leu Ser Arg Glu Phe Ala 
            260                 265                 270         


Asn Phe Val Leu His Asp Pro Arg Ala Val Asp Leu Leu Gln Trp Ser 
        275                 280                 285             


Lys Asp Thr Phe Ser Pro Asp Glu His Phe Trp Val Thr Leu Asn Arg 
    290                 295                 300                 


Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr Gly Asn 
305                 310                 315                 320 


Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly Gly Cys 
                325                 330                 335     


His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly Asp Leu 
            340                 345                 350         


Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe Glu Leu 
        355                 360                 365             


Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His Arg Glu 
    370                 375                 380                 


Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp Tyr Phe 
385                 390                 395                 400 


<210>  231
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  231
atgacttcga aatttctctt ggtgtccttc atacttgctg cactgagtct ttcaaccacc       60

ttttctctcc aaccagacca gcaaaaggtt ctactagttt cttttgatgg attccgttgg      120

gattacttat ataaagttcc aacgccccat tttcattata ttatgaaata tggtgttcac      180

gtgaagcaag ttactaatgt ttttattaca aaaacctacc ctaaccatta tactttggta      240

actggcctct ttgcagagaa tcatgggatt gttgcaaatg atatgtttga tcctattcgg      300

aacaaatctt tctccttgga tcacatgaat atttatgatt ccaagttttg ggaagaagcg      360

acaccaatat ggatcacaaa ccagagggca ggacatacta gtggtgcagc catgtggccc      420

ggaacagatg taaaaataca taagcgcttt cctactcatt acatgcctta caatgagtca      480

gtttcatttg aagatagagt tgccaaaatt attgaatggt ttacgtcaaa agagcccata      540

aatcttggtc ttctctattg ggaagaccct gatgacatgg gccaccattt gggacctgac      600

agtccgctca tggggcctgt catttcagat attgacaaga agttaggata tctcatacaa      660

atgctgaaaa aggcaaagtt gtggaacact ctgaacctaa tcatcacaag tgatcatgga      720

atgacgcagt gctctgagga aaggttaata gaacttgacc agtacctgga taaagaccac      780

tataccctga ttgatcaatc tccagtagca gccatcttgc caaaagaagg taaatttgat      840

gaagtctatg aagcactaac tcacgctcat cctaatctta ctgtttacaa aaaagaagac      900

gttccagaaa ggtggcatta caaatacaac agtcgaattc aaccaatcat agcagtggct      960

gatgaagggt ggcacatttt acagaataag tcagatgact ttctgttagg caaccacggt     1020

tacgataatg cgttagcaga tatgcatcca atatttttag cccatggtcc tgccttcaga     1080

aagaatttct caaaagaagc catgaactcc acagatttgt acccactact atgccacctc     1140

ctcaatatca ccgccatgcc acacaatgga tcattctgga atgtccagga tctgctcaat     1200

tcagcaatgc caagggtggt cccttataca cagagtacta tactcctccc tggtagtgtt     1260

aaaccagcag aatatgacca agaggggtca tacccttatt tcataggggt ctctcttggc     1320

agcattatag tgattgtatt ttttgtaatt ttcattaagc atttaattca cagtcaaata     1380

cctgccttac aagatatgca tgctgaaata gctcaaccat tattacaagc ctaa           1434


<210>  232
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln Pro Asp Gln Gln Lys Val Leu Leu 
            20                  25                  30          


Val Ser Phe Asp Gly Phe Arg Trp Asp Tyr Leu Tyr Lys Val Pro Thr 
        35                  40                  45              


Pro His Phe His Tyr Ile Met Lys Tyr Gly Val His Val Lys Gln Val 
    50                  55                  60                  


Thr Asn Val Phe Ile Thr Lys Thr Tyr Pro Asn His Tyr Thr Leu Val 
65                  70                  75                  80  


Thr Gly Leu Phe Ala Glu Asn His Gly Ile Val Ala Asn Asp Met Phe 
                85                  90                  95      


Asp Pro Ile Arg Asn Lys Ser Phe Ser Leu Asp His Met Asn Ile Tyr 
            100                 105                 110         


Asp Ser Lys Phe Trp Glu Glu Ala Thr Pro Ile Trp Ile Thr Asn Gln 
        115                 120                 125             


Arg Ala Gly His Thr Ser Gly Ala Ala Met Trp Pro Gly Thr Asp Val 
    130                 135                 140                 


Lys Ile His Lys Arg Phe Pro Thr His Tyr Met Pro Tyr Asn Glu Ser 
145                 150                 155                 160 


Val Ser Phe Glu Asp Arg Val Ala Lys Ile Ile Glu Trp Phe Thr Ser 
                165                 170                 175     


Lys Glu Pro Ile Asn Leu Gly Leu Leu Tyr Trp Glu Asp Pro Asp Asp 
            180                 185                 190         


Met Gly His His Leu Gly Pro Asp Ser Pro Leu Met Gly Pro Val Ile 
        195                 200                 205             


Ser Asp Ile Asp Lys Lys Leu Gly Tyr Leu Ile Gln Met Leu Lys Lys 
    210                 215                 220                 


Ala Lys Leu Trp Asn Thr Leu Asn Leu Ile Ile Thr Ser Asp His Gly 
225                 230                 235                 240 


Met Thr Gln Cys Ser Glu Glu Arg Leu Ile Glu Leu Asp Gln Tyr Leu 
                245                 250                 255     


Asp Lys Asp His Tyr Thr Leu Ile Asp Gln Ser Pro Val Ala Ala Ile 
            260                 265                 270         


Leu Pro Lys Glu Gly Lys Phe Asp Glu Val Tyr Glu Ala Leu Thr His 
        275                 280                 285             


Ala His Pro Asn Leu Thr Val Tyr Lys Lys Glu Asp Val Pro Glu Arg 
    290                 295                 300                 


Trp His Tyr Lys Tyr Asn Ser Arg Ile Gln Pro Ile Ile Ala Val Ala 
305                 310                 315                 320 


Asp Glu Gly Trp His Ile Leu Gln Asn Lys Ser Asp Asp Phe Leu Leu 
                325                 330                 335     


Gly Asn His Gly Tyr Asp Asn Ala Leu Ala Asp Met His Pro Ile Phe 
            340                 345                 350         


Leu Ala His Gly Pro Ala Phe Arg Lys Asn Phe Ser Lys Glu Ala Met 
        355                 360                 365             


Asn Ser Thr Asp Leu Tyr Pro Leu Leu Cys His Leu Leu Asn Ile Thr 
    370                 375                 380                 


Ala Met Pro His Asn Gly Ser Phe Trp Asn Val Gln Asp Leu Leu Asn 
385                 390                 395                 400 


Ser Ala Met Pro Arg Val Val Pro Tyr Thr Gln Ser Thr Ile Leu Leu 
                405                 410                 415     


Pro Gly Ser Val Lys Pro Ala Glu Tyr Asp Gln Glu Gly Ser Tyr Pro 
            420                 425                 430         


Tyr Phe Ile Gly Val Ser Leu Gly Ser Ile Ile Val Ile Val Phe Phe 
        435                 440                 445             


Val Ile Phe Ile Lys His Leu Ile His Ser Gln Ile Pro Ala Leu Gln 
    450                 455                 460                 


Asp Met His Ala Glu Ile Ala Gln Pro Leu Leu Gln Ala 
465                 470                 475         


<210>  233
<211>  1770
<212>  DNA
<213>  Homo sapiens

<400>  233
atggacggtg aggcagtccg cttctgcaca gataaccagt gtgtctccct gcacccccaa       60

gaggtggact ctgtggcaat ggctcctgca gcccccaaga taccgaggct cgttcaggct      120

accccggcat ttatggctgt gaccttggtc ttctctcttg tgactctctt tgtagtggtt      180

caacagcaga caagacctgt tccgaagcct gtgcaagccg taattctggg agacaacatt      240

actgggcatt taccttttga acccaacaat catcaccact ttggcaggga ggcagaaatg      300

cgagagctta tccagacatt taaaggccac atggagaatt ccagtgcctg ggtagtagaa      360

atccagatgt tgaagtgcag agtggacaat gtcaattcgc agctccaggt gctcggtgat      420

catctgggaa acaccaatgc tgacatccag atggtaaaag gagttctaaa ggatgccact      480

acattgagtt tgcagacaca gatgttaagg agttccctgg agggaaccaa tgctgagatc      540

cagaggctca aggaagacct tgaaaaggca gatgctttaa ctttccagac gctgaatttc      600

ttaaaaagca gtttagaaaa caccagcatt gagctccacg tgctaagcag aggcttagaa      660

aatgcaaact ctgaaattca gatgttgaat gccagtttgg aaacggcaaa tacccaggct      720

cagttagcca atagcagttt aaagaacgct aatgctgaga tctatgtttt gagaggccat      780

ctagatagtg tcaatgactt gaggacccag aaccaggttt taagaaatag tttggaagga      840

gccaatgctg agatccaggg actaaaggaa aatttgcaga acacaaatgc tttaaactcc      900

cagacccagg cctttataaa aagcagtttt gacaacacta gtgctgagat ccagttctta      960

agaggtcatt tggaaagagc tggtgatgaa attcacgtgt taaaaaggga tttgaaaatg     1020

gtcacagccc agacccaaaa agcaaatggc cgtctggacc agacagatac tcagattcag     1080

gtattcaagt cagagatgga aaatgtgaat accttaaatg cccagattca ggtcttaaat     1140

ggtcatatga aaaatgccag cagagagata cagaccctaa aacaaggaat gaagaatgct     1200

tcagccttaa cttcccagac ccagatgtta gacagcaatc tgcagaaggc cagtgccgag     1260

atccagaggt taagagggga tctagagaac accaaagctc taaccatgga aatccagcag     1320

gagcagagtc gcctgaagac cctccatgtg gtcattactt cacaggaaca gctacaaaga     1380

acccaaagtc agcttctcca gatggtcctg caaggctgga agttcaatgg tggaagctta     1440

tattattttt ctagtgtcaa gaagtcttgg catgaggctg agcagttctg cgtgtcccag     1500

ggagcccatc tggcatctgt ggcctccaag gaggagcagg catttctggt agagttcaca     1560

agtaaagtgt actactggat cggtctcact gacaggggca cagagggctc ctggcgctgg     1620

acagatggga caccattcaa cgccgcccag aacaaagcgc ctggttccaa gggatcctgc     1680

ccactcagaa agtatattat tgtgaattct gggatgggag cttgcagctt catagacacc     1740

cctccctgtc cctggatcct cagtaactaa                                      1770


<210>  234
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Asp Gly Glu Ala Val Arg Phe Cys Thr Asp Asn Gln Cys Val Ser 
1               5                   10                  15      


Leu His Pro Gln Glu Val Asp Ser Val Ala Met Ala Pro Ala Ala Pro 
            20                  25                  30          


Lys Ile Pro Arg Leu Val Gln Ala Thr Pro Ala Phe Met Ala Val Thr 
        35                  40                  45              


Leu Val Phe Ser Leu Val Thr Leu Phe Val Val Val Gln Gln Gln Thr 
    50                  55                  60                  


Arg Pro Val Pro Lys Pro Val Gln Ala Val Ile Leu Gly Asp Asn Ile 
65                  70                  75                  80  


Thr Gly His Leu Pro Phe Glu Pro Asn Asn His His His Phe Gly Arg 
                85                  90                  95      


Glu Ala Glu Met Arg Glu Leu Ile Gln Thr Phe Lys Gly His Met Glu 
            100                 105                 110         


Asn Ser Ser Ala Trp Val Val Glu Ile Gln Met Leu Lys Cys Arg Val 
        115                 120                 125             


Asp Asn Val Asn Ser Gln Leu Gln Val Leu Gly Asp His Leu Gly Asn 
    130                 135                 140                 


Thr Asn Ala Asp Ile Gln Met Val Lys Gly Val Leu Lys Asp Ala Thr 
145                 150                 155                 160 


Thr Leu Ser Leu Gln Thr Gln Met Leu Arg Ser Ser Leu Glu Gly Thr 
                165                 170                 175     


Asn Ala Glu Ile Gln Arg Leu Lys Glu Asp Leu Glu Lys Ala Asp Ala 
            180                 185                 190         


Leu Thr Phe Gln Thr Leu Asn Phe Leu Lys Ser Ser Leu Glu Asn Thr 
        195                 200                 205             


Ser Ile Glu Leu His Val Leu Ser Arg Gly Leu Glu Asn Ala Asn Ser 
    210                 215                 220                 


Glu Ile Gln Met Leu Asn Ala Ser Leu Glu Thr Ala Asn Thr Gln Ala 
225                 230                 235                 240 


Gln Leu Ala Asn Ser Ser Leu Lys Asn Ala Asn Ala Glu Ile Tyr Val 
                245                 250                 255     


Leu Arg Gly His Leu Asp Ser Val Asn Asp Leu Arg Thr Gln Asn Gln 
            260                 265                 270         


Val Leu Arg Asn Ser Leu Glu Gly Ala Asn Ala Glu Ile Gln Gly Leu 
        275                 280                 285             


Lys Glu Asn Leu Gln Asn Thr Asn Ala Leu Asn Ser Gln Thr Gln Ala 
    290                 295                 300                 


Phe Ile Lys Ser Ser Phe Asp Asn Thr Ser Ala Glu Ile Gln Phe Leu 
305                 310                 315                 320 


Arg Gly His Leu Glu Arg Ala Gly Asp Glu Ile His Val Leu Lys Arg 
                325                 330                 335     


Asp Leu Lys Met Val Thr Ala Gln Thr Gln Lys Ala Asn Gly Arg Leu 
            340                 345                 350         


Asp Gln Thr Asp Thr Gln Ile Gln Val Phe Lys Ser Glu Met Glu Asn 
        355                 360                 365             


Val Asn Thr Leu Asn Ala Gln Ile Gln Val Leu Asn Gly His Met Lys 
    370                 375                 380                 


Asn Ala Ser Arg Glu Ile Gln Thr Leu Lys Gln Gly Met Lys Asn Ala 
385                 390                 395                 400 


Ser Ala Leu Thr Ser Gln Thr Gln Met Leu Asp Ser Asn Leu Gln Lys 
                405                 410                 415     


Ala Ser Ala Glu Ile Gln Arg Leu Arg Gly Asp Leu Glu Asn Thr Lys 
            420                 425                 430         


Ala Leu Thr Met Glu Ile Gln Gln Glu Gln Ser Arg Leu Lys Thr Leu 
        435                 440                 445             


His Val Val Ile Thr Ser Gln Glu Gln Leu Gln Arg Thr Gln Ser Gln 
    450                 455                 460                 


Leu Leu Gln Met Val Leu Gln Gly Trp Lys Phe Asn Gly Gly Ser Leu 
465                 470                 475                 480 


Tyr Tyr Phe Ser Ser Val Lys Lys Ser Trp His Glu Ala Glu Gln Phe 
                485                 490                 495     


Cys Val Ser Gln Gly Ala His Leu Ala Ser Val Ala Ser Lys Glu Glu 
            500                 505                 510         


Gln Ala Phe Leu Val Glu Phe Thr Ser Lys Val Tyr Tyr Trp Ile Gly 
        515                 520                 525             


Leu Thr Asp Arg Gly Thr Glu Gly Ser Trp Arg Trp Thr Asp Gly Thr 
    530                 535                 540                 


Pro Phe Asn Ala Ala Gln Asn Lys Ala Pro Gly Ser Lys Gly Ser Cys 
545                 550                 555                 560 


Pro Leu Arg Lys Tyr Ile Ile Val Asn Ser Gly Met Gly Ala Cys Ser 
                565                 570                 575     


Phe Ile Asp Thr Pro Pro Cys Pro Trp Ile Leu Ser Asn 
            580                 585                 


<210>  235
<211>  3120
<212>  DNA
<213>  Homo sapiens

<400>  235
atgcaatccc ggcttctact cctcggggca cccggaggcc acggcggccc ggcctcgcgg       60

cgcatgcggc tgctcctgcg gcaggtggtg cagcgcaggc cgggtggcga caggcagcgg      120

ccggaggtca gactgttgca cgccggctcg ggggccgaca caggtgatac agttaatatt      180

ggagatgtat cctacaagtt gaaaattcct aagaatccag aacttgtgcc acagaactac      240

atttcagact ctctggctca atctgtagtt cagcatctaa gatggataat gcagaaggat      300

cttttggggc aagatgtttt tctaatagga cctcctgggc ctcttcgacg ctctattgct      360

atgcagtact tggagctgac caaacgggag gtcgaataca ttgccctgtc aagggacacc      420

actgaaactg atctcaaaca gcgacgagag atccgtgcag gcacagcctt ttacattgat      480

cagtgtgcag ttcgtgcagc cacagaaggc agaactctca ttttggaagg tttggaaaag      540

gcagagagga atgttttgcc tgttttgaac aacttgctgg aaaacagaga gatgcagctt      600

gaagatggac gcttcctgat gtctgctgag cgttacgaca aacttctccg agatcatacc      660

aaaaaagagt tggattcttg gaaaattgtc cgagttagtg aaaatttccg agtgattgcc      720

ttgggcttgc cagtgccaag gtattctggg aatccattag acccccctct tcgttctcga      780

tttcaagcca gggatattta ttatttaccc ttcaaggacc aacttaagtt gttatattca      840

attggagcca atgtttctgc tgagaaagtt tctcagctct tgtcctttgc cacaactctg      900

tgttcccaag aatcttctac tcttggactt ccagactttc ctttagatag tttagcagct      960

gcggttcaaa tcttggattc ctttcctatg atgccaatca aacatgcaat ccagtggctt     1020

tatccatata gtattttact aggtcatgaa gggaagatgg ctgtggaagg tgttttaaag     1080

cgctttgaac ttcaagattc aggaagctct ctacttccta aagagattgt aaaagtagag     1140

aagatgatgg aaaaccatgt gtcccaagct tctgtgacca tccggattgc agataaagag     1200

gtgaccatta aggtgccagc cgggaccagg ctattaagtc aaccttgtgc gtcagaccgt     1260

ttcatacaga ctttgagcca taagcagcta caggctgaaa tgatgcagtc tcacatggtt     1320

aaagatatat gtttaattgg aggaaagggt tgtggaaaaa cagtgatcgc taagaacttt     1380

gccgatacct taggatacaa catagaacct attatgctct atcaggatat gacagcgcgt     1440

gatctgctac agcagagata cacccttcca aatggagaca ctgcctggcg gtcctcaccc     1500

cttgtgaatg ctgctctgga aggcaagctg gtcctgctgg atggcattca ccgggtgaat     1560

gcgggcacgc ttgctgtatt gcaaaggtta atccatgatc gagagctaag cctctatgat     1620

ggttctaggc tgctgagaga agacaggtat atgcgtttaa aggaggagct gcaactgtct     1680

gatgaacagc tacagaagag atccattttt cctatccatc cctccttcag aatcattgcc     1740

ttggcagaac cccctgttat tggaagcaca gcacaccagt ggctgggacc agaattctta     1800

accatgttct ttttccatta catgaaacca cttgtgaaaa gtgaagaaat ccaagtgatt     1860

aaggaaaagg tcccaaatgt acctcaggaa gctctggata agttattatc atttacacac     1920

aaactcagag aaacacagga tccaacggca caatcattag cggcatcact ttctaccaga     1980

caactgttgc gaatttctcg tcggctgtca cagtatccta atgaaaatct tcacagtgct     2040

gttactaaag cctgcctttc caggttttta cccagtcttg ctaggtcagc attagaaaaa     2100

aatctggcag atgctacaat agaaataaat actgatgaca atttggagcc agaactgaag     2160

gattacaaat gtgaagtaac atctggaact ctgaggattg gtgctgttag tgcaccgatc     2220

tataatgcac atgagaaaat gaaagtgcct gatgttcttt tctatgacaa cattcagcat     2280

gtgatagtga tggaagatat gctgaaagac tttctccttg gagaacactt attattggtt     2340

ggcaaccagg gtgtaggaaa aaacaagatt gttgacagat tccttcacct gctcaacaga     2400

ccccgagaat atattcagct acacagggat accacagtac aaactcttac gcttcagcct     2460

tcggttaaag acggacttat tgtatatgaa gactcacctt tggttaaagc agtaaagttg     2520

ggtcatattc tggtagtaga tgaggctgac aaagctccaa caaatgtcac gtgtatttta     2580

aaaactctag tagaaaatgg agaaatgatt ctagcagatg gaagacgcat tgttgcaaat     2640

tctgctaatg tgaatggaag agaaaatgtt gtagtgattc atcctgattt taggatgatt     2700

gttctggcaa atagacctgg atttcctttc ctaggcaatg atttcttcgg taccttaggt     2760

gatattttta gctgccatgc agttgataac cccaaacccc actcggagct cgagatgctc     2820

agacagtatg gaccaaatgt gcctgagccc atccttcaga agcttgtggc tgcctttgga     2880

gagctgagga gtttggctga ccaagggatt attaactatc cttattctac cagagaagtt     2940

gtcaacatag tcaaacattt acagaaattt ccgactgaag gtctctccag tgtagttcga     3000

aatgtgtttg actttgattc ctacaacaat gacatgaggg agatattgat taacacttta     3060

cacaaatacg ggatacctat cggagcaaag cctaccagtg tgcagctggc aaaggagtaa     3120


<210>  236
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Gln Ser Arg Leu Leu Leu Leu Gly Ala Pro Gly Gly His Gly Gly 
1               5                   10                  15      


Pro Ala Ser Arg Arg Met Arg Leu Leu Leu Arg Gln Val Val Gln Arg 
            20                  25                  30          


Arg Pro Gly Gly Asp Arg Gln Arg Pro Glu Val Arg Leu Leu His Ala 
        35                  40                  45              


Gly Ser Gly Ala Asp Thr Gly Asp Thr Val Asn Ile Gly Asp Val Ser 
    50                  55                  60                  


Tyr Lys Leu Lys Ile Pro Lys Asn Pro Glu Leu Val Pro Gln Asn Tyr 
65                  70                  75                  80  


Ile Ser Asp Ser Leu Ala Gln Ser Val Val Gln His Leu Arg Trp Ile 
                85                  90                  95      


Met Gln Lys Asp Leu Leu Gly Gln Asp Val Phe Leu Ile Gly Pro Pro 
            100                 105                 110         


Gly Pro Leu Arg Arg Ser Ile Ala Met Gln Tyr Leu Glu Leu Thr Lys 
        115                 120                 125             


Arg Glu Val Glu Tyr Ile Ala Leu Ser Arg Asp Thr Thr Glu Thr Asp 
    130                 135                 140                 


Leu Lys Gln Arg Arg Glu Ile Arg Ala Gly Thr Ala Phe Tyr Ile Asp 
145                 150                 155                 160 


Gln Cys Ala Val Arg Ala Ala Thr Glu Gly Arg Thr Leu Ile Leu Glu 
                165                 170                 175     


Gly Leu Glu Lys Ala Glu Arg Asn Val Leu Pro Val Leu Asn Asn Leu 
            180                 185                 190         


Leu Glu Asn Arg Glu Met Gln Leu Glu Asp Gly Arg Phe Leu Met Ser 
        195                 200                 205             


Ala Glu Arg Tyr Asp Lys Leu Leu Arg Asp His Thr Lys Lys Glu Leu 
    210                 215                 220                 


Asp Ser Trp Lys Ile Val Arg Val Ser Glu Asn Phe Arg Val Ile Ala 
225                 230                 235                 240 


Leu Gly Leu Pro Val Pro Arg Tyr Ser Gly Asn Pro Leu Asp Pro Pro 
                245                 250                 255     


Leu Arg Ser Arg Phe Gln Ala Arg Asp Ile Tyr Tyr Leu Pro Phe Lys 
            260                 265                 270         


Asp Gln Leu Lys Leu Leu Tyr Ser Ile Gly Ala Asn Val Ser Ala Glu 
        275                 280                 285             


Lys Val Ser Gln Leu Leu Ser Phe Ala Thr Thr Leu Cys Ser Gln Glu 
    290                 295                 300                 


Ser Ser Thr Leu Gly Leu Pro Asp Phe Pro Leu Asp Ser Leu Ala Ala 
305                 310                 315                 320 


Ala Val Gln Ile Leu Asp Ser Phe Pro Met Met Pro Ile Lys His Ala 
                325                 330                 335     


Ile Gln Trp Leu Tyr Pro Tyr Ser Ile Leu Leu Gly His Glu Gly Lys 
            340                 345                 350         


Met Ala Val Glu Gly Val Leu Lys Arg Phe Glu Leu Gln Asp Ser Gly 
        355                 360                 365             


Ser Ser Leu Leu Pro Lys Glu Ile Val Lys Val Glu Lys Met Met Glu 
    370                 375                 380                 


Asn His Val Ser Gln Ala Ser Val Thr Ile Arg Ile Ala Asp Lys Glu 
385                 390                 395                 400 


Val Thr Ile Lys Val Pro Ala Gly Thr Arg Leu Leu Ser Gln Pro Cys 
                405                 410                 415     


Ala Ser Asp Arg Phe Ile Gln Thr Leu Ser His Lys Gln Leu Gln Ala 
            420                 425                 430         


Glu Met Met Gln Ser His Met Val Lys Asp Ile Cys Leu Ile Gly Gly 
        435                 440                 445             


Lys Gly Cys Gly Lys Thr Val Ile Ala Lys Asn Phe Ala Asp Thr Leu 
    450                 455                 460                 


Gly Tyr Asn Ile Glu Pro Ile Met Leu Tyr Gln Asp Met Thr Ala Arg 
465                 470                 475                 480 


Asp Leu Leu Gln Gln Arg Tyr Thr Leu Pro Asn Gly Asp Thr Ala Trp 
                485                 490                 495     


Arg Ser Ser Pro Leu Val Asn Ala Ala Leu Glu Gly Lys Leu Val Leu 
            500                 505                 510         


Leu Asp Gly Ile His Arg Val Asn Ala Gly Thr Leu Ala Val Leu Gln 
        515                 520                 525             


Arg Leu Ile His Asp Arg Glu Leu Ser Leu Tyr Asp Gly Ser Arg Leu 
    530                 535                 540                 


Leu Arg Glu Asp Arg Tyr Met Arg Leu Lys Glu Glu Leu Gln Leu Ser 
545                 550                 555                 560 


Asp Glu Gln Leu Gln Lys Arg Ser Ile Phe Pro Ile His Pro Ser Phe 
                565                 570                 575     


Arg Ile Ile Ala Leu Ala Glu Pro Pro Val Ile Gly Ser Thr Ala His 
            580                 585                 590         


Gln Trp Leu Gly Pro Glu Phe Leu Thr Met Phe Phe Phe His Tyr Met 
        595                 600                 605             


Lys Pro Leu Val Lys Ser Glu Glu Ile Gln Val Ile Lys Glu Lys Val 
    610                 615                 620                 


Pro Asn Val Pro Gln Glu Ala Leu Asp Lys Leu Leu Ser Phe Thr His 
625                 630                 635                 640 


Lys Leu Arg Glu Thr Gln Asp Pro Thr Ala Gln Ser Leu Ala Ala Ser 
                645                 650                 655     


Leu Ser Thr Arg Gln Leu Leu Arg Ile Ser Arg Arg Leu Ser Gln Tyr 
            660                 665                 670         


Pro Asn Glu Asn Leu His Ser Ala Val Thr Lys Ala Cys Leu Ser Arg 
        675                 680                 685             


Phe Leu Pro Ser Leu Ala Arg Ser Ala Leu Glu Lys Asn Leu Ala Asp 
    690                 695                 700                 


Ala Thr Ile Glu Ile Asn Thr Asp Asp Asn Leu Glu Pro Glu Leu Lys 
705                 710                 715                 720 


Asp Tyr Lys Cys Glu Val Thr Ser Gly Thr Leu Arg Ile Gly Ala Val 
                725                 730                 735     


Ser Ala Pro Ile Tyr Asn Ala His Glu Lys Met Lys Val Pro Asp Val 
            740                 745                 750         


Leu Phe Tyr Asp Asn Ile Gln His Val Ile Val Met Glu Asp Met Leu 
        755                 760                 765             


Lys Asp Phe Leu Leu Gly Glu His Leu Leu Leu Val Gly Asn Gln Gly 
    770                 775                 780                 


Val Gly Lys Asn Lys Ile Val Asp Arg Phe Leu His Leu Leu Asn Arg 
785                 790                 795                 800 


Pro Arg Glu Tyr Ile Gln Leu His Arg Asp Thr Thr Val Gln Thr Leu 
                805                 810                 815     


Thr Leu Gln Pro Ser Val Lys Asp Gly Leu Ile Val Tyr Glu Asp Ser 
            820                 825                 830         


Pro Leu Val Lys Ala Val Lys Leu Gly His Ile Leu Val Val Asp Glu 
        835                 840                 845             


Ala Asp Lys Ala Pro Thr Asn Val Thr Cys Ile Leu Lys Thr Leu Val 
    850                 855                 860                 


Glu Asn Gly Glu Met Ile Leu Ala Asp Gly Arg Arg Ile Val Ala Asn 
865                 870                 875                 880 


Ser Ala Asn Val Asn Gly Arg Glu Asn Val Val Val Ile His Pro Asp 
                885                 890                 895     


Phe Arg Met Ile Val Leu Ala Asn Arg Pro Gly Phe Pro Phe Leu Gly 
            900                 905                 910         


Asn Asp Phe Phe Gly Thr Leu Gly Asp Ile Phe Ser Cys His Ala Val 
        915                 920                 925             


Asp Asn Pro Lys Pro His Ser Glu Leu Glu Met Leu Arg Gln Tyr Gly 
    930                 935                 940                 


Pro Asn Val Pro Glu Pro Ile Leu Gln Lys Leu Val Ala Ala Phe Gly 
945                 950                 955                 960 


Glu Leu Arg Ser Leu Ala Asp Gln Gly Ile Ile Asn Tyr Pro Tyr Ser 
                965                 970                 975     


Thr Arg Glu Val Val Asn Ile Val Lys His Leu Gln Lys Phe Pro Thr 
            980                 985                 990         


Glu Gly Leu Ser Ser Val Val Arg  Asn Val Phe Asp Phe  Asp Ser Tyr 
        995                 1000                 1005             


Asn Asn  Asp Met Arg Glu Ile  Leu Ile Asn Thr Leu  His Lys Tyr 
    1010                 1015                 1020             


Gly Ile  Pro Ile Gly Ala Lys  Pro Thr Ser Val Gln  Leu Ala Lys 
    1025                 1030                 1035             


Glu 
    


<210>  237
<211>  2178
<212>  DNA
<213>  Homo sapiens

<400>  237
atggcagacg aagatctcat cttccgcctg gaaggcgttg atggcggcca gtccccccga       60

gctggccatg atggtgattc tgatggggac agcgacgatg aggaaggtta cttcatctgc      120

cccatcacgg atgacccaag ctcgaaccag aatgtcaatt ccaaggttaa taagtactac      180

agcaacctaa caaaaagtga gcggtatagc tccagcgggt ccccggcaaa ctccttccac      240

ttcaaggaag cctggaagca cgcaatccag aaggccaagc acatgcccga cccctgggct      300

gagttccacc tggaagatat tgccaccgaa cgtgctactc gacacaggta caacgccgtc      360

accggggaat ggctggatga tgaagttctg atcaagatgg catctcagcc cttcggccga      420

ggagcaatga gggagtgctt ccggacgaag aagctctcca acttcttgca tgcccagcag      480

tggaagggcg cctccaacta cgtggcgaag cgctacatcg agcccgtaga ccgggatgtg      540

tactttgagg acgtgcgtct acagatggag gccaagctct ggggggagga gtataatcgg      600

cacaagcccc ccaagcaggt ggacatcatg cagatgtgca tcatcgagct gaaggacaga      660

ccgggcaagc ccctcttcca cctggagcac tacatcgagg gcaagtacat caagtacaac      720

tccaactctg gctttgtccg cgatgacaac atccgcctga cgccgcaggc cttcagccac      780

ttcacttttg agcgttccgg ccatcagctg atagtggtgg acatccaggg agttggggat      840

ctctacactg acccacagat ccacacggag acgggcactg actttggaga cggcaaccta      900

ggtgtccgcg ggatggcgct cttcttctac tctcatgcct gcaaccggat ttgcgagagc      960

atgggccttg ctccctttga cctctcgccc cgggagaggg atgcagtgaa tcagaacacc     1020

aagctgctgc aatcagccaa gaccatcttg agaggaacag aggaaaaatg tgggagcccc     1080

caagtaagga ccctctctgg gagccggcca cccctgctcc gtcccctttc agagaactct     1140

ggagacgaga acatgagcga cgtgaccttc gactctctcc cttcttcccc atcttcggcc     1200

acaccacaca gccagaagct agaccacctc cattggccag tgttcagtga cctcgataac     1260

atggcatcca gagaccatga tcatctagac aaccaccggg agtctgagaa tagtggggac     1320

agcggatacc ccagtgagaa gcggggtgag ctggatgacc ctgagccccg agaacatggc     1380

cactcataca gtaatcggaa gtacgagtct gacgaagaca gcctgggcag ctctggacgg     1440

gtatgtgtag agaagtggaa tctcctcaac tcctcccgcc tccacctgcc gagggcttcg     1500

gccgtggccc tggaagtgca aaggcttaat gctctggacc tcgaaaagaa aatcgggaag     1560

tccattttgg ggaaggtcca tctggccatg gtgcgctacc acgagggtgg gcgcttctgc     1620

gagaagggcg aggagtggga ccaggagtcg gctgtcttcc acctggagca cgcagccaac     1680

ctgggcgagc tggaggccat cgtgggcctg ggactcatgt actcgcagtt gcctcatcac     1740

atcctagccg atgtctctct gaaggagaca gaagagaaca aaaccaaagg atttgattac     1800

ttactaaagg ccgctgaagc tggcgacagg cagtccatga tcctagtggc gcgagctttt     1860

gactctggcc agaacctcag cccggacagg tgccaagact ggctagaggc cctgcactgg     1920

tacaacactg ccctggagat gacggactgt gatgagggcg gtgagtacga cggaatgcag     1980

gacgagcccc ggtacatgat gctggccagg gaggccgaga tgctgttcac aggaggctac     2040

gggctggaga aggacccgca gagatcaggg gacttgtata cccaggcagc agaggcagcg     2100

atggaagcca tgaagggccg actggccaac cagtactacc aaaaggctga agaggcctgg     2160

gcccagatgg aggagtaa                                                   2178


<210>  238
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Ala Asp Glu Asp Leu Ile Phe Arg Leu Glu Gly Val Asp Gly Gly 
1               5                   10                  15      


Gln Ser Pro Arg Ala Gly His Asp Gly Asp Ser Asp Gly Asp Ser Asp 
            20                  25                  30          


Asp Glu Glu Gly Tyr Phe Ile Cys Pro Ile Thr Asp Asp Pro Ser Ser 
        35                  40                  45              


Asn Gln Asn Val Asn Ser Lys Val Asn Lys Tyr Tyr Ser Asn Leu Thr 
    50                  55                  60                  


Lys Ser Glu Arg Tyr Ser Ser Ser Gly Ser Pro Ala Asn Ser Phe His 
65                  70                  75                  80  


Phe Lys Glu Ala Trp Lys His Ala Ile Gln Lys Ala Lys His Met Pro 
                85                  90                  95      


Asp Pro Trp Ala Glu Phe His Leu Glu Asp Ile Ala Thr Glu Arg Ala 
            100                 105                 110         


Thr Arg His Arg Tyr Asn Ala Val Thr Gly Glu Trp Leu Asp Asp Glu 
        115                 120                 125             


Val Leu Ile Lys Met Ala Ser Gln Pro Phe Gly Arg Gly Ala Met Arg 
    130                 135                 140                 


Glu Cys Phe Arg Thr Lys Lys Leu Ser Asn Phe Leu His Ala Gln Gln 
145                 150                 155                 160 


Trp Lys Gly Ala Ser Asn Tyr Val Ala Lys Arg Tyr Ile Glu Pro Val 
                165                 170                 175     


Asp Arg Asp Val Tyr Phe Glu Asp Val Arg Leu Gln Met Glu Ala Lys 
            180                 185                 190         


Leu Trp Gly Glu Glu Tyr Asn Arg His Lys Pro Pro Lys Gln Val Asp 
        195                 200                 205             


Ile Met Gln Met Cys Ile Ile Glu Leu Lys Asp Arg Pro Gly Lys Pro 
    210                 215                 220                 


Leu Phe His Leu Glu His Tyr Ile Glu Gly Lys Tyr Ile Lys Tyr Asn 
225                 230                 235                 240 


Ser Asn Ser Gly Phe Val Arg Asp Asp Asn Ile Arg Leu Thr Pro Gln 
                245                 250                 255     


Ala Phe Ser His Phe Thr Phe Glu Arg Ser Gly His Gln Leu Ile Val 
            260                 265                 270         


Val Asp Ile Gln Gly Val Gly Asp Leu Tyr Thr Asp Pro Gln Ile His 
        275                 280                 285             


Thr Glu Thr Gly Thr Asp Phe Gly Asp Gly Asn Leu Gly Val Arg Gly 
    290                 295                 300                 


Met Ala Leu Phe Phe Tyr Ser His Ala Cys Asn Arg Ile Cys Glu Ser 
305                 310                 315                 320 


Met Gly Leu Ala Pro Phe Asp Leu Ser Pro Arg Glu Arg Asp Ala Val 
                325                 330                 335     


Asn Gln Asn Thr Lys Leu Leu Gln Ser Ala Lys Thr Ile Leu Arg Gly 
            340                 345                 350         


Thr Glu Glu Lys Cys Gly Ser Pro Gln Val Arg Thr Leu Ser Gly Ser 
        355                 360                 365             


Arg Pro Pro Leu Leu Arg Pro Leu Ser Glu Asn Ser Gly Asp Glu Asn 
    370                 375                 380                 


Met Ser Asp Val Thr Phe Asp Ser Leu Pro Ser Ser Pro Ser Ser Ala 
385                 390                 395                 400 


Thr Pro His Ser Gln Lys Leu Asp His Leu His Trp Pro Val Phe Ser 
                405                 410                 415     


Asp Leu Asp Asn Met Ala Ser Arg Asp His Asp His Leu Asp Asn His 
            420                 425                 430         


Arg Glu Ser Glu Asn Ser Gly Asp Ser Gly Tyr Pro Ser Glu Lys Arg 
        435                 440                 445             


Gly Glu Leu Asp Asp Pro Glu Pro Arg Glu His Gly His Ser Tyr Ser 
    450                 455                 460                 


Asn Arg Lys Tyr Glu Ser Asp Glu Asp Ser Leu Gly Ser Ser Gly Arg 
465                 470                 475                 480 


Val Cys Val Glu Lys Trp Asn Leu Leu Asn Ser Ser Arg Leu His Leu 
                485                 490                 495     


Pro Arg Ala Ser Ala Val Ala Leu Glu Val Gln Arg Leu Asn Ala Leu 
            500                 505                 510         


Asp Leu Glu Lys Lys Ile Gly Lys Ser Ile Leu Gly Lys Val His Leu 
        515                 520                 525             


Ala Met Val Arg Tyr His Glu Gly Gly Arg Phe Cys Glu Lys Gly Glu 
    530                 535                 540                 


Glu Trp Asp Gln Glu Ser Ala Val Phe His Leu Glu His Ala Ala Asn 
545                 550                 555                 560 


Leu Gly Glu Leu Glu Ala Ile Val Gly Leu Gly Leu Met Tyr Ser Gln 
                565                 570                 575     


Leu Pro His His Ile Leu Ala Asp Val Ser Leu Lys Glu Thr Glu Glu 
            580                 585                 590         


Asn Lys Thr Lys Gly Phe Asp Tyr Leu Leu Lys Ala Ala Glu Ala Gly 
        595                 600                 605             


Asp Arg Gln Ser Met Ile Leu Val Ala Arg Ala Phe Asp Ser Gly Gln 
    610                 615                 620                 


Asn Leu Ser Pro Asp Arg Cys Gln Asp Trp Leu Glu Ala Leu His Trp 
625                 630                 635                 640 


Tyr Asn Thr Ala Leu Glu Met Thr Asp Cys Asp Glu Gly Gly Glu Tyr 
                645                 650                 655     


Asp Gly Met Gln Asp Glu Pro Arg Tyr Met Met Leu Ala Arg Glu Ala 
            660                 665                 670         


Glu Met Leu Phe Thr Gly Gly Tyr Gly Leu Glu Lys Asp Pro Gln Arg 
        675                 680                 685             


Ser Gly Asp Leu Tyr Thr Gln Ala Ala Glu Ala Ala Met Glu Ala Met 
    690                 695                 700                 


Lys Gly Arg Leu Ala Asn Gln Tyr Tyr Gln Lys Ala Glu Glu Ala Trp 
705                 710                 715                 720 


Ala Gln Met Glu Glu 
                725 


<210>  239
<211>  3627
<212>  DNA
<213>  Homo sapiens

<400>  239
atggagccgc ttttacttgg aagaggacta atcgtatatc taatgttcct cctgttaaaa       60

ttctcaaaag caattgaaat accatcttca gttcaacagg ttccaacaat cataaaacag      120

tcaaaagtcc aagttgcctt tcccttcgat gagtattttc aaattgaatg tgaagctaaa      180

ggaaatccag aaccaacatt ttcgtggact aaggatggca acccttttta tttcactgac      240

catcggataa ttccatcgaa caattcagga acattcagga tcccaaacga ggggcacata      300

tctcactttc aagggaaata ccgctgcttt gcttcaaata aactgggaat cgctatgtca      360

gaagaaatag aatttatagt tccaagtgtt ccaaaattcc caaaagaaaa aattgaccct      420

cttgaagtgg aggagggaga tccaattgtc ctcccatgca atcctcccaa aggcctccca      480

cctttacaca tttattggat gaatattgaa ttagaacaca tcgaacaaga tgaaagagta      540

tacatgagcc aaaagggaga tctatacttc gcaaacgtgg aagaaaagga cagtcgcaat      600

gactactgtt gctttgctgc atttccaaga ttaaggacta ttgtacagaa aatgccaatg      660

aaactaacag ttaacagttc aaattccatc aagcaaagaa aacccaaact gctgttgcct      720

cccactgaga gtggcagtga gtcttcaatt accatcctca aaggggaaat cttgctgctt      780

gagtgttttg ctgaaggctt gccaactcca caggttgatt ggaacaaaat tggtggtgac      840

ttaccaaagg ggagagaagc aaaagaaaat tatggcaaga ctttgaagat agagaatgtc      900

tcctaccagg acaaaggaaa ttatcgctgc acagccagca atttcttggg aacagccact      960

cacgattttc acgttatagt agaagagcct cctcgctgga caaagaagcc tcagagtgct     1020

gtgtatagca ccggaagcaa tggcatcttg ttatgtgagg ctgaaggaga acctcaaccc     1080

acaatcaagt ggagagtcaa tggctcccca gttgacaatc atccatttgc tggtgatgtt     1140

gtcttcccca gggaaatcag ttttaccaac cttcaaccaa atcatactgc tgtgtaccag     1200

tgtgaagcct caaatgtcca tggaactatc cttgccaatg ccaatattga tgttgtggat     1260

gtccgtccat tgatacaaac caaagatgga gaaaattacg ctacagtggt tgggtacagt     1320

gctttcttac attgcgagtt ctttgcttca cctgaggcag tcgtgtcctg gcagaaggtg     1380

gaagaagtga aacccctgga gggcaggcgg tatcatatct atgaaaatgg cacattgcag     1440

atcaacagaa ccaccgaaga agatgctggg tcttactcat gttgggtaga aaatgctata     1500

ggaaaaactg cagtcacagc caatttggat attagaaatg ctacaaaact tagagtttct     1560

cctaagaatc ctcgtatccc caaattgcat atgcttgaat tacattgtga aagcaaatgt     1620

gactcacatt tgaaacacag tttgaagttg tcctggagta aagatggaga agcctttgaa     1680

attaatggca cagaagatgg caggataatt attgatggag ctaatttgac catatctaat     1740

gtaactttag aggaccaagg tatttactgc tgttcagctc atactgctct agacagtgct     1800

gccgatataa ctcaagtaac tgttcttgat gttccggatc caccagaaaa ccttcacttg     1860

tctgaaagac agaacaggag tgttcggctg acctgggaag ctggagctga ccacaacagc     1920

aatattagcg agtatattgt tgaatttgaa ggaaacaaag aagagcctgg aaggtgggag     1980

gaactgacca gagtccaagg aaagaaaacc acagttatct tacctttggc tccatttgtg     2040

agataccagt tcagggtcat agccgtgaac gaagtaggga gaagtcagcc tagccagccg     2100

tcagaccatc atgaaacacc accagcagct ccagatagga atccacaaaa cataagggtt     2160

caagcctctc aacccaagga aatgattata aagtgggagc ctttgaaatc catggagcag     2220

aatggaccag gcctagagta cagagtgacc tggaagccac agggagcccc agtggagtgg     2280

gaagaagaaa cagtcacaaa ccacacattg cgggtgatga cgcctgctgt ctatgcccct     2340

tatgatgtca aggtccaggc tatcaatcaa ctaggatctg ggcctgaccc tcagtcagtg     2400

actctctatt ctggagaaga ctatcctgat acagctccag tgatccatgg ggtggacgtt     2460

ataaacagta cattagttaa agttacctgg tcaacagttc caaaggacag agtacatgga     2520

cgtctgaaag gctatcagat aaattggtgg aaaacaaaaa gtctgttgga tggaagaaca     2580

catcccaaag aagtgaacat tctaagattt tcaggacaaa gaaactctgg aatggttcct     2640

tccttagatg cctttagtga atttcattta acagtcttag cctataactc taaaggagct     2700

ggtcctgaaa gtgagcctta tatatttcaa acaccagaag gagtacctga acagccaact     2760

tttctaaagg tcatcaaagt tgataaagac actgccactt tatcttgggg actacctaag     2820

aaattaaatg gaaacttaac tggctatctt ttgcaatatc agataataaa tgacacctac     2880

gagattggag aattaaatga tattaacatt acaactccat caaagcccag ctggcacctc     2940

tcaaacctga atgcaactac caagtacaaa ttctacttga gggcttgcac ttcacagggc     3000

tgtggaaaac cgatcacgga ggaaagctcc accttaggag aagggagtaa aggtatcggg     3060

aagatatcag gagtaaatct tactcaaaag actcacccag tagaggtatt tgagccggga     3120

gctgaacata tagttcgcct aatgactaag aattggggcg ataacgatag catttttcaa     3180

gatgtaattg agacaagagg gagagaatat gctggtttat atgatgacat ctccactcaa     3240

ggctggttta ttggactgat gtgtgcgatt gctcttctca cactactatt attaactgtt     3300

tgctttgtga agaggaatag aggtggaaag tactcagtta aagaaaagga agatttgcat     3360

ccagacccag aaattcagtc agtaaaagat gaaacctttg gtgaatacag tgacagtgat     3420

gaaaagcctc tcaaaggaag ccttcggtcc cttaataggg atatgcagcc tactgaaagt     3480

gctgacagct tagtcgaata cggagaggga gaccatggtc tcttcagtga agatggatca     3540

tttattggtg cctacgctgg atctaaggag aagggatctg ttgaaagcaa tggaagttct     3600

acagcaactt ttccccttcg ggcataa                                         3627


<210>  240
<211>  1208
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Ser Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
225                 230                 235                 240 


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
                245                 250                 255     


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
            260                 265                 270         


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Ala Lys 
        275                 280                 285             


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
    290                 295                 300                 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
305                 310                 315                 320 


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
                325                 330                 335     


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
            340                 345                 350         


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
        355                 360                 365             


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
    370                 375                 380                 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
385                 390                 395                 400 


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
                405                 410                 415     


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
            420                 425                 430         


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
        435                 440                 445             


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
    450                 455                 460                 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
465                 470                 475                 480 


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
                485                 490                 495     


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
            500                 505                 510         


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
        515                 520                 525             


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
    530                 535                 540                 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
545                 550                 555                 560 


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
                565                 570                 575     


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
            580                 585                 590         


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
        595                 600                 605             


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
    610                 615                 620                 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
625                 630                 635                 640 


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
                645                 650                 655     


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
            660                 665                 670         


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
        675                 680                 685             


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
    690                 695                 700                 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
705                 710                 715                 720 


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
                725                 730                 735     


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
            740                 745                 750         


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
        755                 760                 765             


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
    770                 775                 780                 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
785                 790                 795                 800 


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
                805                 810                 815     


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
            820                 825                 830         


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
        835                 840                 845             


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
    850                 855                 860                 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
865                 870                 875                 880 


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
                885                 890                 895     


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
            900                 905                 910         


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
        915                 920                 925             


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
    930                 935                 940                 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
945                 950                 955                 960 


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
                965                 970                 975     


Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr 
            980                 985                 990         


Leu Arg Ala Cys Thr Ser Gln Gly  Cys Gly Lys Pro Ile  Thr Glu Glu 
        995                 1000                 1005             


Ser Ser  Thr Leu Gly Glu Gly  Ser Lys Gly Ile Gly  Lys Ile Ser 
    1010                 1015                 1020             


Gly Val  Asn Leu Thr Gln Lys  Thr His Pro Val Glu  Val Phe Glu 
    1025                 1030                 1035             


Pro Gly  Ala Glu His Ile Val  Arg Leu Met Thr Lys  Asn Trp Gly 
    1040                 1045                 1050             


Asp Asn  Asp Ser Ile Phe Gln  Asp Val Ile Glu Thr  Arg Gly Arg 
    1055                 1060                 1065             


Glu Tyr  Ala Gly Leu Tyr Asp  Asp Ile Ser Thr Gln  Gly Trp Phe 
    1070                 1075                 1080             


Ile Gly  Leu Met Cys Ala Ile  Ala Leu Leu Thr Leu  Leu Leu Leu 
    1085                 1090                 1095             


Thr Val  Cys Phe Val Lys Arg  Asn Arg Gly Gly Lys  Tyr Ser Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Asp Leu His  Pro Asp Pro Glu Ile  Gln Ser Val 
    1115                 1120                 1125             


Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp Ser Asp  Glu Lys Pro 
    1130                 1135                 1140             


Leu Lys  Gly Ser Leu Arg Ser  Leu Asn Arg Asp Met  Gln Pro Thr 
    1145                 1150                 1155             


Glu Ser  Ala Asp Ser Leu Val  Glu Tyr Gly Glu Gly  Asp His Gly 
    1160                 1165                 1170             


Leu Phe  Ser Glu Asp Gly Ser  Phe Ile Gly Ala Tyr  Ala Gly Ser 
    1175                 1180                 1185             


Lys Glu  Lys Gly Ser Val Glu  Ser Asn Gly Ser Ser  Thr Ala Thr 
    1190                 1195                 1200             


Phe Pro  Leu Arg Ala 
    1205             


<210>  241
<211>  2292
<212>  DNA
<213>  Homo sapiens

<400>  241
atggaggcgt ctctaaccag gaggctactc tttaaagaca ggcattttac ttgcagcaaa       60

ataataggaa ggagattcgc ttgctttgca cagaggctga gccacaggag aaagcaaagc      120

caatgtgatt tattgaatga aagcactgga caattaccaa caacttgttc ctctgctgcc      180

tcgaacagca taaactggaa ttgtcgtgtg aaaatgacgc aacaaatgca aaatttacat      240

ctctgtcagt caaaaaaaca tagtgctccc tcatctccca acgcagccaa acgcctgtac      300

aggaacctct ctgagaaact gaaagggagc cactcttcct tcgatgaggc ctattttagg      360

acaagaactg atcggctgag tctcaggaag acctcggtga atttccaggg caatgaagcc      420

atgtttgagg cagtcgaaca gcaggacatg gatgctgtgc agatcctcct gtatcagtac      480

acaccagaag aacttgacct caacacacct aacagcgagg gcttgacacc cctggatatt      540

gccatcatga ccaacaatgt gcccattgca aggattcttc tgaggacagg ggcccgagaa      600

agtccacact ttgtcagcct ggaaagccga gcaatgcacc taaacacact ggtccaggaa      660

gcccaggaga gggtgagtga actgtctgcc caggtggaga atgaaggatt cactctggac      720

aacacagaga aagagaaaca gctgaaagct tgggagtgga ggtatcggct ctacagacgc      780

atgaaaacag gctttgagca tgccagagcc cctgagatgc caaccaatgt ctgtctcatg      840

gtaaccagca gcacatcact cactgtcagc ttccaagagc ctcttagcgt caatgcagct      900

gtagtaacca ggtataaagt ggaatggagt atgtccgaag acttttctcc tttggctgga      960

gaaatcatca tggataatct gcagactctg agatgcacaa tcacaggact tacaatgggc     1020

caacagtatt ttgttcaagt ctcggcttac aatatgaaag gatggggacc tgctcagacc     1080

acgacaccgg catgtgcctc tccttctaac tggaaagact atgacgacag agagcccaga     1140

cacaagggac agagtgaagt tttggaaggt ctgctgcagc aggtccgagc ccttcatcag     1200

cattacagtt gccgggaaag cacaaaatta caaaccacag gccgcaagca gtcagtctca     1260

agaagcctga aacacctgtt ccattcctcg aacaagtttg tgaagacctt aaaacgggga     1320

ctctacatag ccattatatt ttattacaaa gacaatatct tagtcaccaa tgaagatcaa     1380

gtaccaattg ttgaaataga tgactctcac accagttcta ttacacaaga ttttctgtgg     1440

ttcacgaagc tgtcttgtat gtgggaagat ataaggtggc tgaggcaaag cataccaata     1500

tcctcatcct catccacagt gctgcaaact cggcagaaga tgctcgcagc aacagcacag     1560

ctacagaatt tacttgggac acacaacttg ggaagagttt actatgagcc cattaaagat     1620

cgacatggaa acatactcat agtcaccatc agggaggtgg agatgcttta ttcatttttt     1680

aatggcaaat ggatgcagat ctcaaagctg caaagccaga gaaagtctct atcaacacct     1740

gaggagccaa cagctttaga cattctactg ataaccatcc aggatattct atcctatcac     1800

aaaaggagtc atcagcgtct ctttcctgga ttatatctgg gttacctaaa gctctgtagc     1860

tctgtggatc aaatcaaagt tcttgttacc caaaagttgc ccaacattct ctgccacgtg     1920

aagatccgtg aaaacaataa tatttctaga gaggaatggg aatggatcca aaagctttct     1980

ggctctgaat ctatggaaag tgtggatcat acttctgact gccccatgca attgttcttc     2040

tacgagctcc agatggcagt gaaagctctc cttcagcaga tcaatatacc tctacaccag     2100

gcaaggaact tccgcctcta cacacaggag gtgttggaaa tgggtcacaa tgtgtccttt     2160

cttctcctgc tccctgcctc agacgacgtc tgtacagccc caggacagaa taatccttac     2220

accccacact cagggtttct taacctccct cttcagatgt ttgaacttgg tatagtagct     2280

tgtttcacct ag                                                         2292


<210>  242
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Glu Ala Ser Leu Thr Arg Arg Leu Leu Phe Lys Asp Arg His Phe 
1               5                   10                  15      


Thr Cys Ser Lys Ile Ile Gly Arg Arg Phe Ala Cys Phe Ala Gln Arg 
            20                  25                  30          


Leu Ser His Arg Arg Lys Gln Ser Gln Cys Asp Leu Leu Asn Glu Ser 
        35                  40                  45              


Thr Gly Gln Leu Pro Thr Thr Cys Ser Ser Ala Ala Ser Asn Ser Ile 
    50                  55                  60                  


Asn Trp Asn Cys Arg Val Lys Met Thr Gln Gln Met Gln Asn Leu His 
65                  70                  75                  80  


Leu Cys Gln Ser Lys Lys His Ser Ala Pro Ser Ser Pro Asn Ala Ala 
                85                  90                  95      


Lys Arg Leu Tyr Arg Asn Leu Ser Glu Lys Leu Lys Gly Ser His Ser 
            100                 105                 110         


Ser Phe Asp Glu Ala Tyr Phe Arg Thr Arg Thr Asp Arg Leu Ser Leu 
        115                 120                 125             


Arg Lys Thr Ser Val Asn Phe Gln Gly Asn Glu Ala Met Phe Glu Ala 
    130                 135                 140                 


Val Glu Gln Gln Asp Met Asp Ala Val Gln Ile Leu Leu Tyr Gln Tyr 
145                 150                 155                 160 


Thr Pro Glu Glu Leu Asp Leu Asn Thr Pro Asn Ser Glu Gly Leu Thr 
                165                 170                 175     


Pro Leu Asp Ile Ala Ile Met Thr Asn Asn Val Pro Ile Ala Arg Ile 
            180                 185                 190         


Leu Leu Arg Thr Gly Ala Arg Glu Ser Pro His Phe Val Ser Leu Glu 
        195                 200                 205             


Ser Arg Ala Met His Leu Asn Thr Leu Val Gln Glu Ala Gln Glu Arg 
    210                 215                 220                 


Val Ser Glu Leu Ser Ala Gln Val Glu Asn Glu Gly Phe Thr Leu Asp 
225                 230                 235                 240 


Asn Thr Glu Lys Glu Lys Gln Leu Lys Ala Trp Glu Trp Arg Tyr Arg 
                245                 250                 255     


Leu Tyr Arg Arg Met Lys Thr Gly Phe Glu His Ala Arg Ala Pro Glu 
            260                 265                 270         


Met Pro Thr Asn Val Cys Leu Met Val Thr Ser Ser Thr Ser Leu Thr 
        275                 280                 285             


Val Ser Phe Gln Glu Pro Leu Ser Val Asn Ala Ala Val Val Thr Arg 
    290                 295                 300                 


Tyr Lys Val Glu Trp Ser Met Ser Glu Asp Phe Ser Pro Leu Ala Gly 
305                 310                 315                 320 


Glu Ile Ile Met Asp Asn Leu Gln Thr Leu Arg Cys Thr Ile Thr Gly 
                325                 330                 335     


Leu Thr Met Gly Gln Gln Tyr Phe Val Gln Val Ser Ala Tyr Asn Met 
            340                 345                 350         


Lys Gly Trp Gly Pro Ala Gln Thr Thr Thr Pro Ala Cys Ala Ser Pro 
        355                 360                 365             


Ser Asn Trp Lys Asp Tyr Asp Asp Arg Glu Pro Arg His Lys Gly Gln 
    370                 375                 380                 


Ser Glu Val Leu Glu Gly Leu Leu Gln Gln Val Arg Ala Leu His Gln 
385                 390                 395                 400 


His Tyr Ser Cys Arg Glu Ser Thr Lys Leu Gln Thr Thr Gly Arg Lys 
                405                 410                 415     


Gln Ser Val Ser Arg Ser Leu Lys His Leu Phe His Ser Ser Asn Lys 
            420                 425                 430         


Phe Val Lys Thr Leu Lys Arg Gly Leu Tyr Ile Ala Ile Ile Phe Tyr 
        435                 440                 445             


Tyr Lys Asp Asn Ile Leu Val Thr Asn Glu Asp Gln Val Pro Ile Val 
    450                 455                 460                 


Glu Ile Asp Asp Ser His Thr Ser Ser Ile Thr Gln Asp Phe Leu Trp 
465                 470                 475                 480 


Phe Thr Lys Leu Ser Cys Met Trp Glu Asp Ile Arg Trp Leu Arg Gln 
                485                 490                 495     


Ser Ile Pro Ile Ser Ser Ser Ser Ser Thr Val Leu Gln Thr Arg Gln 
            500                 505                 510         


Lys Met Leu Ala Ala Thr Ala Gln Leu Gln Asn Leu Leu Gly Thr His 
        515                 520                 525             


Asn Leu Gly Arg Val Tyr Tyr Glu Pro Ile Lys Asp Arg His Gly Asn 
    530                 535                 540                 


Ile Leu Ile Val Thr Ile Arg Glu Val Glu Met Leu Tyr Ser Phe Phe 
545                 550                 555                 560 


Asn Gly Lys Trp Met Gln Ile Ser Lys Leu Gln Ser Gln Arg Lys Ser 
                565                 570                 575     


Leu Ser Thr Pro Glu Glu Pro Thr Ala Leu Asp Ile Leu Leu Ile Thr 
            580                 585                 590         


Ile Gln Asp Ile Leu Ser Tyr His Lys Arg Ser His Gln Arg Leu Phe 
        595                 600                 605             


Pro Gly Leu Tyr Leu Gly Tyr Leu Lys Leu Cys Ser Ser Val Asp Gln 
    610                 615                 620                 


Ile Lys Val Leu Val Thr Gln Lys Leu Pro Asn Ile Leu Cys His Val 
625                 630                 635                 640 


Lys Ile Arg Glu Asn Asn Asn Ile Ser Arg Glu Glu Trp Glu Trp Ile 
                645                 650                 655     


Gln Lys Leu Ser Gly Ser Glu Ser Met Glu Ser Val Asp His Thr Ser 
            660                 665                 670         


Asp Cys Pro Met Gln Leu Phe Phe Tyr Glu Leu Gln Met Ala Val Lys 
        675                 680                 685             


Ala Leu Leu Gln Gln Ile Asn Ile Pro Leu His Gln Ala Arg Asn Phe 
    690                 695                 700                 


Arg Leu Tyr Thr Gln Glu Val Leu Glu Met Gly His Asn Val Ser Phe 
705                 710                 715                 720 


Leu Leu Leu Leu Pro Ala Ser Asp Asp Val Cys Thr Ala Pro Gly Gln 
                725                 730                 735     


Asn Asn Pro Tyr Thr Pro His Ser Gly Phe Leu Asn Leu Pro Leu Gln 
            740                 745                 750         


Met Phe Glu Leu Gly Ile Val Ala Cys Phe Thr 
        755                 760             


<210>  243
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  243
atgggactct tggtatttgt gcgcaatctg ctgctagccc tctgcctctt tctggtactg       60

ggatttttgt attattctgc gtggaagcta cacttactcc agtgggagga ggactccaat      120

tcagtggttc tttcctttga ctccgctgga caaacactag gctcagagta tgatcggttg      180

ggcttcctcc tgaatctgga ctctaaactg cctgctgaat tagccaccaa gtacgcaaac      240

ttttcagagg gagcttgcaa gcctggctat gcttcagcct tgatgacggc catcttcccc      300

cggttctcca agccagcacc catgttcctg gatgactcct ttcgcaagtg ggctagaatc      360

cgggagttcg tgccgccttt tgggatcaaa ggtcaagaca atctgatcaa agccatcttg      420

tcagtcacca aagagtaccg cctgacccct gccttggaca gcctccgctg ccgccgctgc      480

atcatcgtgg gcaatggagg cgttcttgcc aacaagtctc tggggtcacg aattgacgac      540

tatgacattg tggtgagact gaattcagca ccagtgaaag gctttgagaa ggacgtgggc      600

agcaaaacga cactgcgcat cacctacccc gagggcgcca tgcagcggcc tgagcagtac      660

gagcgcgatt ctctctttgt cctcgccggc ttcaagtggc aggactttaa gtggttgaaa      720

tacatcgtct acaaggagag agtgagtgca tcggatggct tctggaaatc tgtggccact      780

cgagtgccca aggagccccc tgagattcga atcctcaacc catatttcat ccaggaggcc      840

gccttcaccc tcattggcct gcccttcaac aatggcctca tgggccgggg gaacatccct      900

acccttggca gtgtggcagt gaccatggca ctacacggct gtgacgaggt ggcagtcgca      960

ggatttggct atgacatgag cacacccaac gcacccctgc actactatga gaccgttcgc     1020

atggcagcca tcaaagagtc ctggacgcac aatatccagc gagagaaaga gtttctgcgg     1080

aagctggtga aagctcgcgt catcactgat ctaagcagtg gcatctga                  1128


<210>  244
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser 
        35                  40                  45              


Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu 
    50                  55                  60                  


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
65                  70                  75                  80  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
                85                  90                  95      


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
            100                 105                 110         


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
        115                 120                 125             


Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys 
    130                 135                 140                 


Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys 
145                 150                 155                 160 


Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser 
                165                 170                 175     


Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val 
            180                 185                 190         


Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr 
        195                 200                 205             


Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser 
    210                 215                 220                 


Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys 
225                 230                 235                 240 


Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys 
                245                 250                 255     


Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu 
            260                 265                 270         


Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro 
        275                 280                 285             


Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser 
    290                 295                 300                 


Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala 
305                 310                 315                 320 


Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr 
                325                 330                 335     


Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile 
            340                 345                 350         


Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile 
        355                 360                 365             


Thr Asp Leu Ser Ser Gly Ile 
    370                 375 


<210>  245
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  245
atgggacggg cagtcaaggt tttacagctc tttaaaacac tgcacaggac cagacaacaa       60

gtttttaaaa atgatgccag agcattagaa gcagccagaa taaagataaa tgaagaattc      120

aaaaataata aaagtgaaac ttcttctaag aaaatagaag agctaatgaa aataggttct      180

gatgttgaat tattactcag aacatctgtt atacaaggta ttcacacaga ccacaataca      240

ctgaaactgg tccctaggaa agaccttctt gtagaaaatg tgccatattg tgatgcacca      300

actcagaagc aatga                                                       315


<210>  246
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Gly Arg Ala Val Lys Val Leu Gln Leu Phe Lys Thr Leu His Arg 
1               5                   10                  15      


Thr Arg Gln Gln Val Phe Lys Asn Asp Ala Arg Ala Leu Glu Ala Ala 
            20                  25                  30          


Arg Ile Lys Ile Asn Glu Glu Phe Lys Asn Asn Lys Ser Glu Thr Ser 
        35                  40                  45              


Ser Lys Lys Ile Glu Glu Leu Met Lys Ile Gly Ser Asp Val Glu Leu 
    50                  55                  60                  


Leu Leu Arg Thr Ser Val Ile Gln Gly Ile His Thr Asp His Asn Thr 
65                  70                  75                  80  


Leu Lys Leu Val Pro Arg Lys Asp Leu Leu Val Glu Asn Val Pro Tyr 
                85                  90                  95      


Cys Asp Ala Pro Thr Gln Lys Gln 
            100                 


<210>  247
<211>  1764
<212>  DNA
<213>  Homo sapiens

<400>  247
atgaatgaca gcctgtttgt cagtttggac agacttttgc tagaatttgt cttccagtat       60

gagcaagaca taagtactaa agaagagatg attcaaagaa ttaataaatg ctgtgaagat      120

attaaggaaa acaaagtaac tatttgtagg atacacgaaa ctataaatgc aacagatgag      180

gaaattgatc attactgtaa acatagtgag gagattaaag acaactgtag aaactggaag      240

ccaacatgtg atgtttttcg taaacatgaa gattatatgc aggaccaatt tactgtttat      300

caaggaactg ttgaaaaaga caaagaaatg tatcatgatt atatatgtca gtataaagaa      360

gttttgaagc agtaccaact aaaatactca gaaacaccct tttcacgtga atattatgag      420

aagaaaagag aacatgaaga aattcaaagc agagtgttgg catgtactga acaattaaaa      480

atgaatgaaa caatttttat gaaatttcga gtgcctgctc cctttccatc acttactaaa      540

tggactttaa acattgttaa tttgagatgt gaaacacaag atattcttaa acatgccagc      600

aatcttacca aaagttcatc cgaattgaag aaagaagtag atgaaatgga aatagaaatt      660

aattatttaa accagcagat atctaggcat aatgaaacta aggctctttc agaaactctg      720

gaagaaaaga acaaaaatac agaaaacaga aaagaactga aagaaagaat ttttggaaaa      780

gatgagcatg tacttacatt gaataaaact caaagcagtc aattatttct tccttatgaa      840

tctcagaaat tagtaagacc aataaagatg cattcttcag aaccaagagt tgcagatata      900

aaagaagaaa gttctgtgaa gcagtcaaag cttgccaata ttgactttag acaaaaagaa      960

aatgatacac agatatttaa tgactctgct gtggataacc attcaaaatg ttcacatatt     1020

acgactatca caagttcaca aaagtttatg caagtcagat tgttaacccc acagaaacaa     1080

tcaaattcca atcagtggtc ggaaaaaggg gataaagatg ctgagtatgg agataaaggg     1140

acagtaagac aagtaagaga atcaaaatgt acttcacaag ctatatatac tgaacatttt     1200

gggaagtcaa tagaaaatga tagtgatgaa gtagaagaga gagctgagaa ttttccacga     1260

acgtctgaaa ttcctatatt tttaggaact cccaaagctg tgaaagcacc tgagtcattg     1320

gagaaaataa aattccctaa aacccccccg ttcgaaatta acagaaatag aaatgcagta     1380

cctgaagttc aaacagaaaa ggaatcccct ggactttctt ttcttatgag ttatacttct     1440

agatcacctg gattgaattt atttgattct tctgtatttg atacagaaat ctcatcagat     1500

cagtttaatg aacattattc tgcaagaaat ctaaatcctc tgtcatcaga gcaagagatt     1560

ggaaacttat ttgagaagcc agaaggagaa gatggcttta cattttcttt tccatcagac     1620

acttcaactc atacatttgg agctggaaaa gatgatttta gttttccatt ttcatttgga     1680

cagggtcaaa attcaatacc ttcttcttct ttaaaaggtt tttcatcttc ctcacaaaat     1740

acaacacagt ttactttttt ttga                                            1764


<210>  248
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Thr Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Thr Ile 
        35                  40                  45              


Cys Arg Ile His Glu Thr Ile Asn Ala Thr Asp Glu Glu Ile Asp His 
    50                  55                  60                  


Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys 
65                  70                  75                  80  


Pro Thr Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met Gln Asp Gln 
                85                  90                  95      


Phe Thr Val Tyr Gln Gly Thr Val Glu Lys Asp Lys Glu Met Tyr His 
            100                 105                 110         


Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr Gln Leu Lys 
        115                 120                 125             


Tyr Ser Glu Thr Pro Phe Ser Arg Glu Tyr Tyr Glu Lys Lys Arg Glu 
    130                 135                 140                 


His Glu Glu Ile Gln Ser Arg Val Leu Ala Cys Thr Glu Gln Leu Lys 
145                 150                 155                 160 


Met Asn Glu Thr Ile Phe Met Lys Phe Arg Val Pro Ala Pro Phe Pro 
                165                 170                 175     


Ser Leu Thr Lys Trp Thr Leu Asn Ile Val Asn Leu Arg Cys Glu Thr 
            180                 185                 190         


Gln Asp Ile Leu Lys His Ala Ser Asn Leu Thr Lys Ser Ser Ser Glu 
        195                 200                 205             


Leu Lys Lys Glu Val Asp Glu Met Glu Ile Glu Ile Asn Tyr Leu Asn 
    210                 215                 220                 


Gln Gln Ile Ser Arg His Asn Glu Thr Lys Ala Leu Ser Glu Thr Leu 
225                 230                 235                 240 


Glu Glu Lys Asn Lys Asn Thr Glu Asn Arg Lys Glu Leu Lys Glu Arg 
                245                 250                 255     


Ile Phe Gly Lys Asp Glu His Val Leu Thr Leu Asn Lys Thr Gln Ser 
            260                 265                 270         


Ser Gln Leu Phe Leu Pro Tyr Glu Ser Gln Lys Leu Val Arg Pro Ile 
        275                 280                 285             


Lys Met His Ser Ser Glu Pro Arg Val Ala Asp Ile Lys Glu Glu Ser 
    290                 295                 300                 


Ser Val Lys Gln Ser Lys Leu Ala Asn Ile Asp Phe Arg Gln Lys Glu 
305                 310                 315                 320 


Asn Asp Thr Gln Ile Phe Asn Asp Ser Ala Val Asp Asn His Ser Lys 
                325                 330                 335     


Cys Ser His Ile Thr Thr Ile Thr Ser Ser Gln Lys Phe Met Gln Val 
            340                 345                 350         


Arg Leu Leu Thr Pro Gln Lys Gln Ser Asn Ser Asn Gln Trp Ser Glu 
        355                 360                 365             


Lys Gly Asp Lys Asp Ala Glu Tyr Gly Asp Lys Gly Thr Val Arg Gln 
    370                 375                 380                 


Val Arg Glu Ser Lys Cys Thr Ser Gln Ala Ile Tyr Thr Glu His Phe 
385                 390                 395                 400 


Gly Lys Ser Ile Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu 
                405                 410                 415     


Asn Phe Pro Arg Thr Ser Glu Ile Pro Ile Phe Leu Gly Thr Pro Lys 
            420                 425                 430         


Ala Val Lys Ala Pro Glu Ser Leu Glu Lys Ile Lys Phe Pro Lys Thr 
        435                 440                 445             


Pro Pro Phe Glu Ile Asn Arg Asn Arg Asn Ala Val Pro Glu Val Gln 
    450                 455                 460                 


Thr Glu Lys Glu Ser Pro Gly Leu Ser Phe Leu Met Ser Tyr Thr Ser 
465                 470                 475                 480 


Arg Ser Pro Gly Leu Asn Leu Phe Asp Ser Ser Val Phe Asp Thr Glu 
                485                 490                 495     


Ile Ser Ser Asp Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn 
            500                 505                 510         


Pro Leu Ser Ser Glu Gln Glu Ile Gly Asn Leu Phe Glu Lys Pro Glu 
        515                 520                 525             


Gly Glu Asp Gly Phe Thr Phe Ser Phe Pro Ser Asp Thr Ser Thr His 
    530                 535                 540                 


Thr Phe Gly Ala Gly Lys Asp Asp Phe Ser Phe Pro Phe Ser Phe Gly 
545                 550                 555                 560 


Gln Gly Gln Asn Ser Ile Pro Ser Ser Ser Leu Lys Gly Phe Ser Ser 
                565                 570                 575     


Ser Ser Gln Asn Thr Thr Gln Phe Thr Phe Phe 
            580                 585         


<210>  249
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  249
atggtttcgc gcgtgcagct cccgcctgag atccagctgg ctcagcgcct ggcggggaat       60

gagcaggtga cccgggaccg ggcggtgagg aagctccgga aatacatcgt cgccaggact      120

cagcgggccg caggtggttt tacgcacgac gagctgctga aggtgtggaa aggactgttt      180

tattgcatgt ggatgcagga caagccactc ctccaggaag aattaggaag gactatttcc      240

cagctcgttc atgcttttca gaccacggag gcgcagcacc tgttccttca ggccttctgg      300

cagaccatga atcgcgagtg gacgggcatt gacaggctgc gcctggataa attctacatg      360

ctcatgcgga tggtcctgaa cgagtccttg aaggttctga agatgcaagg ctgggaagaa      420

agacagatcg aggagctgct agagctgctg atgactgaga tcctgcaccc cagcagccag      480

gcccccaacg gtgtgaagag ccacttcatc gagatcttcc tggaggagct gaccaaagtg      540

ggcgccgagg agcttacggc agaccagaac ctgaagttca tcgacccctt ctgcagaatt      600

gctgcccgga ccaaggattc cttggttttg aacaacatca ctcgaggcat ctttgagacg      660

attgtggagc aggccccgct tgccattgaa gacctcctga atgaactgga cacacaggat      720

gaggaggtgg cgtcggacag tgatgagtcc tctgagggtg gtgagcgtgg agacgcgctg      780

tcccagaaga ggtctgagaa gccgcccgca ggctccatct gcagggctga acctgaggct      840

ggtgaggagc aggcaggtga cgacagggac agtggcggcc ccgttctcca gtttgactac      900

gaggcagttg ctaacagact gtttgaaatg gccagccgcc agagcacccc ttctcagaac      960

agaaagcgtc tctacaaagt gatccggaag ctgcaggacc tggcaggagg cattttccct     1020

gaagatgaga tcccagagaa ggcctgcagg cgcctgcttg aagggaggcg gcagaagaag     1080

acgaagaagc agaagcgtct gctcaggttg cagcaggaga gagggaaagg tgagaaggag     1140

cccccgagcc cgggcatgga gaggaagagg agcaggagga ggggtgtagg ggccgacccc     1200

gaggcgcggg cagaggctgg tgagcagcca ggcacagctg agcgggccct gctccgagat     1260

cagcccaggg gccgtggcca gagaggggct cgccagagaa ggaggacacc tcggcccctg     1320

accagtgccc gagcaaaggc ggccaatgtc caggagccgg agaagaagaa gaaacgcagg     1380

gagtga                                                                1386


<210>  250
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Val Ser Arg Val Gln Leu Pro Pro Glu Ile Gln Leu Ala Gln Arg 
1               5                   10                  15      


Leu Ala Gly Asn Glu Gln Val Thr Arg Asp Arg Ala Val Arg Lys Leu 
            20                  25                  30          


Arg Lys Tyr Ile Val Ala Arg Thr Gln Arg Ala Ala Gly Gly Phe Thr 
        35                  40                  45              


His Asp Glu Leu Leu Lys Val Trp Lys Gly Leu Phe Tyr Cys Met Trp 
    50                  55                  60                  


Met Gln Asp Lys Pro Leu Leu Gln Glu Glu Leu Gly Arg Thr Ile Ser 
65                  70                  75                  80  


Gln Leu Val His Ala Phe Gln Thr Thr Glu Ala Gln His Leu Phe Leu 
                85                  90                  95      


Gln Ala Phe Trp Gln Thr Met Asn Arg Glu Trp Thr Gly Ile Asp Arg 
            100                 105                 110         


Leu Arg Leu Asp Lys Phe Tyr Met Leu Met Arg Met Val Leu Asn Glu 
        115                 120                 125             


Ser Leu Lys Val Leu Lys Met Gln Gly Trp Glu Glu Arg Gln Ile Glu 
    130                 135                 140                 


Glu Leu Leu Glu Leu Leu Met Thr Glu Ile Leu His Pro Ser Ser Gln 
145                 150                 155                 160 


Ala Pro Asn Gly Val Lys Ser His Phe Ile Glu Ile Phe Leu Glu Glu 
                165                 170                 175     


Leu Thr Lys Val Gly Ala Glu Glu Leu Thr Ala Asp Gln Asn Leu Lys 
            180                 185                 190         


Phe Ile Asp Pro Phe Cys Arg Ile Ala Ala Arg Thr Lys Asp Ser Leu 
        195                 200                 205             


Val Leu Asn Asn Ile Thr Arg Gly Ile Phe Glu Thr Ile Val Glu Gln 
    210                 215                 220                 


Ala Pro Leu Ala Ile Glu Asp Leu Leu Asn Glu Leu Asp Thr Gln Asp 
225                 230                 235                 240 


Glu Glu Val Ala Ser Asp Ser Asp Glu Ser Ser Glu Gly Gly Glu Arg 
                245                 250                 255     


Gly Asp Ala Leu Ser Gln Lys Arg Ser Glu Lys Pro Pro Ala Gly Ser 
            260                 265                 270         


Ile Cys Arg Ala Glu Pro Glu Ala Gly Glu Glu Gln Ala Gly Asp Asp 
        275                 280                 285             


Arg Asp Ser Gly Gly Pro Val Leu Gln Phe Asp Tyr Glu Ala Val Ala 
    290                 295                 300                 


Asn Arg Leu Phe Glu Met Ala Ser Arg Gln Ser Thr Pro Ser Gln Asn 
305                 310                 315                 320 


Arg Lys Arg Leu Tyr Lys Val Ile Arg Lys Leu Gln Asp Leu Ala Gly 
                325                 330                 335     


Gly Ile Phe Pro Glu Asp Glu Ile Pro Glu Lys Ala Cys Arg Arg Leu 
            340                 345                 350         


Leu Glu Gly Arg Arg Gln Lys Lys Thr Lys Lys Gln Lys Arg Leu Leu 
        355                 360                 365             


Arg Leu Gln Gln Glu Arg Gly Lys Gly Glu Lys Glu Pro Pro Ser Pro 
    370                 375                 380                 


Gly Met Glu Arg Lys Arg Ser Arg Arg Arg Gly Val Gly Ala Asp Pro 
385                 390                 395                 400 


Glu Ala Arg Ala Glu Ala Gly Glu Gln Pro Gly Thr Ala Glu Arg Ala 
                405                 410                 415     


Leu Leu Arg Asp Gln Pro Arg Gly Arg Gly Gln Arg Gly Ala Arg Gln 
            420                 425                 430         


Arg Arg Arg Thr Pro Arg Pro Leu Thr Ser Ala Arg Ala Lys Ala Ala 
        435                 440                 445             


Asn Val Gln Glu Pro Glu Lys Lys Lys Lys Arg Arg Glu 
    450                 455                 460     


<210>  251
<211>  3513
<212>  DNA
<213>  Homo sapiens

<400>  251
atgtctctgc tcaaccctgt cctgctgccc cccaaggtga aggcctatct gagccaaggg       60

gagcgcttca tcaaatggga tgatgaaact acagttgcct ctccagttat cctccgtgtg      120

gatcctaagg gctactactt atactggacg tatcaaagta aggagatgga gtttctggat      180

atcaccagca tccgggatac tcgctttggg aagtttgcca agatgcccaa gagccagaag      240

ctccgggacg tcttcaacat ggactttcct gataacagtt tcctgctgaa gacactcacg      300

gtggtgtccg gcccggacat ggtggacctc accttccaca acttcgtctc ctacaaggag      360

aacgtgggca aggcctgggc tgaggacgta ctggccctag tcaaacatcc gctgacggcc      420

aacgcctccc gcagcacctt cctggacaag atccttgtga agctcaagat gcagctcaac      480

tctgaaggga agattccggt gaagaacttt ttccagatgt ttcctgctga ccgcaagcgg      540

gtggaagctg ctctcagtgc ctgccacctc cccaaaggca aaaatgacgc catcaatcct      600

gaggacttcc cagaacctgt ctacaagagt ttcctcatga gcctctgtcc tcggccagaa      660

atagatgaga tcttcacttc ttaccatgct aaggccaaac cctacatgac gaaggagcac      720

ctgaccaaat tcatcaacca gaaacagcgg gactcccggc ttaactccct gctgttcccg      780

ccagcacggc ctgaccaggt gcagggcctc atcgacaagt atgagcccag tggcatcaat      840

gcacagaggg gccagctgtc acctgaaggc atggtctggt ttctctgtgg gccagagaac      900

agcgtgctgg cccaggacaa gctgctgctc caccacgaca tgacgcagcc actcaatcat      960

tacttcatca actcgtccca caacacctac ctgacagccg gccagttctc aggcctctcc     1020

tcggctgaga tgtaccgcca ggtgctgctc tctggctgcc gttgcgtgga gctagactgc     1080

tggaagggga aaccccctga cgaggagccc attatcaccc atggcttcac catgaccaca     1140

gacatcttct tcaaagaagc aattgaggct attgcagaaa gtgcctttaa gacctccccc     1200

tatcccatca tcctgtcgtt tgagaaccat gtggactcac cccgccagca ggctaagatg     1260

gctgagtatt gccggacgat ctttggggat atgctgctca cagagcccct ggaaaagttc     1320

ccactaaaac caggtgtccc cctgcccagc cctgaggatc tcaggggcaa gatcctcatc     1380

aagaacaaga agaaccagtt ttctggcccc acctcctcca gtaaggatac tggtggggag     1440

gctgagggca gcagcccacc cagtgcccct gcaggtgagg gcacagtgtg ggctggcgag     1500

gaagggactg agctggagga ggaggaggtg gaagaggaag aggaggagga gtcaggaaac     1560

ctggatgaag aagagattaa gaagatgcag tcggatgagg gcacagcggg cctggaagtg     1620

acggcttatg aggagatgtc cagcctagtc aattacatcc agcccaccaa gttcgtctcc     1680

tttgagttct ctgcccaaaa gaaccgaagt tatgtcatct cgtccttcac agagctcaag     1740

gcatatgacc tgctctccaa ggcctcggtg cagtttgtgg actacaacaa gcgccagatg     1800

agccgcattt accccaaggg aacccgcatg gactcctcca actacatgcc ccagatgttc     1860

tggaatgctg gatgccagat ggttgccctc aacttccaga cgatggactt gcccatgcag     1920

cagaacatgg cagtatttga gttcaacggg cagagcggct acctcctcaa gcatgagttc     1980

atgcgccggc cggacaagca gttcaacccc ttctcagtgg accgcatcga cgtggtggtg     2040

gccaccaccc tttccattac ggtgatctct gggcagttcc tgtcagaacg cagcgtgcgc     2100

acctatgtag aagtggagct gtttggcctt cctggggacc ccaagaggcg ctatcgaact     2160

aagctgtcac ccagtactaa ctccatcaat cctgtctgga aggaggagcc ctttgtcttt     2220

gagaagatct tgatgcctga gctggcctcc ctcagagtgg ctgtgatgga ggaaggcaac     2280

aagtttcttg gacaccgcat catccccatc aatgccctaa attctgggta ccaccacctg     2340

tgcctgcaca gtgagagcaa catgcccctc accatgcctg cgctcttcat cttcctggag     2400

atgaaggact acatacctgg tgcttgggca gatctcactg tggccctcgc caaccccatt     2460

aagttcttca gtgcccatga cacgaagtct gtgaagctca aggaggccat gggaggtctg     2520

cctgagaagc ccttcccact ggcgagtcca gttgccagcc aggtcaatgg ggcgttggcc     2580

ccaacgagca atgggtcacc agagccgcgg accgccagcc tggaggagct ccgggagcta     2640

aagggcgtgg tgaagctgca gcggcggcac gagaaggagc tgcgagagtt ggagcggcgc     2700

ggagcgcggc gctgggagga gctgctgcag cggggcgcgg cgcagctggc ggagctcggg     2760

ccaccgggcg tggggggcgt cggggcctgc aagctcggtc ccggcaaggg ctctcgcaag     2820

aagaggagcc tgccccgcga ggagagcgcc ggagccgcgc cgggcgaggg ccctgagggc     2880

gtggacgggc gcgtgcggga gctgaaagac aggctggagc tggagctgct gcggcagggc     2940

gaggagcagt acgagtgcgt tctgaagcgc aaggagcagc acgtggccga gcaaatctcc     3000

aaaatgatgg agctggccag agagaaacag gcggcagagc tgaaggccct gaaggagacg     3060

tcggagaacg acaccaaaga gatgaagaaa aagctggaga caaagagact ggagcggatc     3120

cagggcatga ccaaagtcac cacagacaag atggcccagg agaggttgaa gagagagatt     3180

aacaactccc acatccagga agtagtgcag gtgatcaagc agatgacgga gaacttggag     3240

aggcaccagg agaagctgga ggagaagcag gcggcttgcc tggaacagat acgggagatg     3300

gaaaagcagt tccagaagga ggcgctggca gagtacgagg ccaggatgaa gggtctggag     3360

gcagaggtga aggagtcggt gagggcctgc ctcaggacct gctttccctc cgaggccaag     3420

gacaagcctg agagggcctg cgagtgcccc ccagagctgt gtgagcagga cccactcata     3480

gcaaaggcag atgcccagga gagccgcctc tga                                  3513


<210>  252
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Leu Leu Asn Pro Val Leu Leu Pro Pro Lys Val Lys Ala Tyr 
1               5                   10                  15      


Leu Ser Gln Gly Glu Arg Phe Ile Lys Trp Asp Asp Glu Thr Thr Val 
            20                  25                  30          


Ala Ser Pro Val Ile Leu Arg Val Asp Pro Lys Gly Tyr Tyr Leu Tyr 
        35                  40                  45              


Trp Thr Tyr Gln Ser Lys Glu Met Glu Phe Leu Asp Ile Thr Ser Ile 
    50                  55                  60                  


Arg Asp Thr Arg Phe Gly Lys Phe Ala Lys Met Pro Lys Ser Gln Lys 
65                  70                  75                  80  


Leu Arg Asp Val Phe Asn Met Asp Phe Pro Asp Asn Ser Phe Leu Leu 
                85                  90                  95      


Lys Thr Leu Thr Val Val Ser Gly Pro Asp Met Val Asp Leu Thr Phe 
            100                 105                 110         


His Asn Phe Val Ser Tyr Lys Glu Asn Val Gly Lys Ala Trp Ala Glu 
        115                 120                 125             


Asp Val Leu Ala Leu Val Lys His Pro Leu Thr Ala Asn Ala Ser Arg 
    130                 135                 140                 


Ser Thr Phe Leu Asp Lys Ile Leu Val Lys Leu Lys Met Gln Leu Asn 
145                 150                 155                 160 


Ser Glu Gly Lys Ile Pro Val Lys Asn Phe Phe Gln Met Phe Pro Ala 
                165                 170                 175     


Asp Arg Lys Arg Val Glu Ala Ala Leu Ser Ala Cys His Leu Pro Lys 
            180                 185                 190         


Gly Lys Asn Asp Ala Ile Asn Pro Glu Asp Phe Pro Glu Pro Val Tyr 
        195                 200                 205             


Lys Ser Phe Leu Met Ser Leu Cys Pro Arg Pro Glu Ile Asp Glu Ile 
    210                 215                 220                 


Phe Thr Ser Tyr His Ala Lys Ala Lys Pro Tyr Met Thr Lys Glu His 
225                 230                 235                 240 


Leu Thr Lys Phe Ile Asn Gln Lys Gln Arg Asp Ser Arg Leu Asn Ser 
                245                 250                 255     


Leu Leu Phe Pro Pro Ala Arg Pro Asp Gln Val Gln Gly Leu Ile Asp 
            260                 265                 270         


Lys Tyr Glu Pro Ser Gly Ile Asn Ala Gln Arg Gly Gln Leu Ser Pro 
        275                 280                 285             


Glu Gly Met Val Trp Phe Leu Cys Gly Pro Glu Asn Ser Val Leu Ala 
    290                 295                 300                 


Gln Asp Lys Leu Leu Leu His His Asp Met Thr Gln Pro Leu Asn His 
305                 310                 315                 320 


Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Phe 
                325                 330                 335     


Ser Gly Leu Ser Ser Ala Glu Met Tyr Arg Gln Val Leu Leu Ser Gly 
            340                 345                 350         


Cys Arg Cys Val Glu Leu Asp Cys Trp Lys Gly Lys Pro Pro Asp Glu 
        355                 360                 365             


Glu Pro Ile Ile Thr His Gly Phe Thr Met Thr Thr Asp Ile Phe Phe 
    370                 375                 380                 


Lys Glu Ala Ile Glu Ala Ile Ala Glu Ser Ala Phe Lys Thr Ser Pro 
385                 390                 395                 400 


Tyr Pro Ile Ile Leu Ser Phe Glu Asn His Val Asp Ser Pro Arg Gln 
                405                 410                 415     


Gln Ala Lys Met Ala Glu Tyr Cys Arg Thr Ile Phe Gly Asp Met Leu 
            420                 425                 430         


Leu Thr Glu Pro Leu Glu Lys Phe Pro Leu Lys Pro Gly Val Pro Leu 
        435                 440                 445             


Pro Ser Pro Glu Asp Leu Arg Gly Lys Ile Leu Ile Lys Asn Lys Lys 
    450                 455                 460                 


Asn Gln Phe Ser Gly Pro Thr Ser Ser Ser Lys Asp Thr Gly Gly Glu 
465                 470                 475                 480 


Ala Glu Gly Ser Ser Pro Pro Ser Ala Pro Ala Gly Glu Gly Thr Val 
                485                 490                 495     


Trp Ala Gly Glu Glu Gly Thr Glu Leu Glu Glu Glu Glu Val Glu Glu 
            500                 505                 510         


Glu Glu Glu Glu Glu Ser Gly Asn Leu Asp Glu Glu Glu Ile Lys Lys 
        515                 520                 525             


Met Gln Ser Asp Glu Gly Thr Ala Gly Leu Glu Val Thr Ala Tyr Glu 
    530                 535                 540                 


Glu Met Ser Ser Leu Val Asn Tyr Ile Gln Pro Thr Lys Phe Val Ser 
545                 550                 555                 560 


Phe Glu Phe Ser Ala Gln Lys Asn Arg Ser Tyr Val Ile Ser Ser Phe 
                565                 570                 575     


Thr Glu Leu Lys Ala Tyr Asp Leu Leu Ser Lys Ala Ser Val Gln Phe 
            580                 585                 590         


Val Asp Tyr Asn Lys Arg Gln Met Ser Arg Ile Tyr Pro Lys Gly Thr 
        595                 600                 605             


Arg Met Asp Ser Ser Asn Tyr Met Pro Gln Met Phe Trp Asn Ala Gly 
    610                 615                 620                 


Cys Gln Met Val Ala Leu Asn Phe Gln Thr Met Asp Leu Pro Met Gln 
625                 630                 635                 640 


Gln Asn Met Ala Val Phe Glu Phe Asn Gly Gln Ser Gly Tyr Leu Leu 
                645                 650                 655     


Lys His Glu Phe Met Arg Arg Pro Asp Lys Gln Phe Asn Pro Phe Ser 
            660                 665                 670         


Val Asp Arg Ile Asp Val Val Val Ala Thr Thr Leu Ser Ile Thr Val 
        675                 680                 685             


Ile Ser Gly Gln Phe Leu Ser Glu Arg Ser Val Arg Thr Tyr Val Glu 
    690                 695                 700                 


Val Glu Leu Phe Gly Leu Pro Gly Asp Pro Lys Arg Arg Tyr Arg Thr 
705                 710                 715                 720 


Lys Leu Ser Pro Ser Thr Asn Ser Ile Asn Pro Val Trp Lys Glu Glu 
                725                 730                 735     


Pro Phe Val Phe Glu Lys Ile Leu Met Pro Glu Leu Ala Ser Leu Arg 
            740                 745                 750         


Val Ala Val Met Glu Glu Gly Asn Lys Phe Leu Gly His Arg Ile Ile 
        755                 760                 765             


Pro Ile Asn Ala Leu Asn Ser Gly Tyr His His Leu Cys Leu His Ser 
    770                 775                 780                 


Glu Ser Asn Met Pro Leu Thr Met Pro Ala Leu Phe Ile Phe Leu Glu 
785                 790                 795                 800 


Met Lys Asp Tyr Ile Pro Gly Ala Trp Ala Asp Leu Thr Val Ala Leu 
                805                 810                 815     


Ala Asn Pro Ile Lys Phe Phe Ser Ala His Asp Thr Lys Ser Val Lys 
            820                 825                 830         


Leu Lys Glu Ala Met Gly Gly Leu Pro Glu Lys Pro Phe Pro Leu Ala 
        835                 840                 845             


Ser Pro Val Ala Ser Gln Val Asn Gly Ala Leu Ala Pro Thr Ser Asn 
    850                 855                 860                 


Gly Ser Pro Glu Pro Arg Thr Ala Ser Leu Glu Glu Leu Arg Glu Leu 
865                 870                 875                 880 


Lys Gly Val Val Lys Leu Gln Arg Arg His Glu Lys Glu Leu Arg Glu 
                885                 890                 895     


Leu Glu Arg Arg Gly Ala Arg Arg Trp Glu Glu Leu Leu Gln Arg Gly 
            900                 905                 910         


Ala Ala Gln Leu Ala Glu Leu Gly Pro Pro Gly Val Gly Gly Val Gly 
        915                 920                 925             


Ala Cys Lys Leu Gly Pro Gly Lys Gly Ser Arg Lys Lys Arg Ser Leu 
    930                 935                 940                 


Pro Arg Glu Glu Ser Ala Gly Ala Ala Pro Gly Glu Gly Pro Glu Gly 
945                 950                 955                 960 


Val Asp Gly Arg Val Arg Glu Leu Lys Asp Arg Leu Glu Leu Glu Leu 
                965                 970                 975     


Leu Arg Gln Gly Glu Glu Gln Tyr Glu Cys Val Leu Lys Arg Lys Glu 
            980                 985                 990         


Gln His Val Ala Glu Gln Ile Ser  Lys Met Met Glu Leu  Ala Arg Glu 
        995                 1000                 1005             


Lys Gln  Ala Ala Glu Leu Lys  Ala Leu Lys Glu Thr  Ser Glu Asn 
    1010                 1015                 1020             


Asp Thr  Lys Glu Met Lys Lys  Lys Leu Glu Thr Lys  Arg Leu Glu 
    1025                 1030                 1035             


Arg Ile  Gln Gly Met Thr Lys  Val Thr Thr Asp Lys  Met Ala Gln 
    1040                 1045                 1050             


Glu Arg  Leu Lys Arg Glu Ile  Asn Asn Ser His Ile  Gln Glu Val 
    1055                 1060                 1065             


Val Gln  Val Ile Lys Gln Met  Thr Glu Asn Leu Glu  Arg His Gln 
    1070                 1075                 1080             


Glu Lys  Leu Glu Glu Lys Gln  Ala Ala Cys Leu Glu  Gln Ile Arg 
    1085                 1090                 1095             


Glu Met  Glu Lys Gln Phe Gln  Lys Glu Ala Leu Ala  Glu Tyr Glu 
    1100                 1105                 1110             


Ala Arg  Met Lys Gly Leu Glu  Ala Glu Val Lys Glu  Ser Val Arg 
    1115                 1120                 1125             


Ala Cys  Leu Arg Thr Cys Phe  Pro Ser Glu Ala Lys  Asp Lys Pro 
    1130                 1135                 1140             


Glu Arg  Ala Cys Glu Cys Pro  Pro Glu Leu Cys Glu  Gln Asp Pro 
    1145                 1150                 1155             


Leu Ile  Ala Lys Ala Asp Ala  Gln Glu Ser Arg Leu  
    1160                 1165                 1170 


<210>  253
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  253
atggagaacg gatacaccta tgaagattat aagaacactg cagaatggct tctgtctcac       60

actaagcacc gacctcaagt tgcaataatc tgtggttctg gattaggagg tctgactgat      120

aaattaactc aggcccagat ctttgactac ggtgaaatcc ccaactttcc ccgaagtaca      180

gtgccaggtc atgctggccg actggtgttt gggttcctga atggcagggc ctgtgtgatg      240

atgcagggca ggttccacat gtatgaaggg tacccactct ggaaggtgac attcccagtg      300

agggttttcc accttctggg tgtggacacc ctggtagtca ccaatgcagc aggagggctg      360

aaccccaagt ttgaggttgg agatatcatg ctgatccgtg accatatcaa cctacctggt      420

ttcagtggtc agaaccctct cagagggccc aatgatgaaa ggtttggaga tcgtttccct      480

gccatgtctg atgcctacga ccggactatg aggcagaggg ctctcagtac ctggaaacaa      540

atgggggagc aacgtgagct acaggaaggc acctatgtga tggtggcagg ccccagcttt      600

gagactgtgg cagaatgtcg tgtgctgcag aagctgggag cagacgctgt tggcatgagt      660

acagtaccag aagttatcgt tgcacggcac tgtggacttc gagtctttgg cttctcactc      720

atcactaaca aggtcatcat ggattatgaa agcctggaga aggccaacca tgaagaagtc      780

ttagcagctg gcaaacaagc tgcacagaaa ttggaacagt ttgtctccat tcttatggcc      840

agcattccac tccctgacaa agccagttga                                       870


<210>  254
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  255
<211>  1605
<212>  DNA
<213>  Homo sapiens

<400>  255
atgaggctgc ggggatgcgg accccgggcc gcccctgcct ccagcgcagg ggccagcgac       60

gctcggctgc tggcgccccc ggggcggaac cccttcgtgc acgagctgcg cctcagcgcc      120

ctgcagaagg cccaggtggc cctcatgaca ctgacgctct tcccggtccg gctcctggtt      180

gccgctgcca tgatgctgct ggcctggccc ctcgcacttg tcgcatccct gggctctgcg      240

gagaaggaac ccgagcagcc cccggccctg tggaggaagg ttgtggactt cctgctgaag      300

gccatcatgc gcaccatgtg gttcgccggc ggcttccacc gggtggccgt gaaggggcgg      360

caggcgctgc ccaccgaggc ggccatcctc acgctcgcgc ctcactcgtc ctacttcgac      420

gccatccctg tgaccatgac gatgtcctcc atcgtgatga aggcagagag cagagacatc      480

ccgatctggg gaactctgat ccagtatata cggcctgtgt tcgtgtcccg gtcagaccag      540

gattctcgca ggaaaacagt agaagaaatc aagagacggg cgcagtccaa cggaaagtgg      600

ccacagataa tgatttttcc agaaggaact tgtacaaaca ggacctgcct aattaccttc      660

aaacctggtg cattcatccc tggagcgccc gtccagcctg tggttttacg atatccaaat      720

aaactggaca ccatcacatg gacgtggcaa ggacctggag cgctggaaat cctgtggctc      780

acgctgtgtc agtttcacaa ccaagtggaa atcgagttcc ttcctgtgta cagcccttct      840

gaggaggaga agaggaaccc cgcgctgtat gccagcaacg tgcggcgagt catggccgag      900

gccttgggtg tctccgtgac tgactacacg ttcgaggact gccagctggc cctggcggaa      960

ggacagctcc gtctccccgc tgacacttgc cttttagaat ttgccaggct cgtgcggggc     1020

ctcgggctaa aaccagaaaa gcttgaaaaa gatctggaca gatactcaga aagagccagg     1080

atgaagggag gagagaagat aggtattgcg gagtttgccg cctccctgga agtccccgtt     1140

tctgacttgc tggaagacat gttttcactg ttcgacgaga gcggcagcgg cgaggtggac     1200

ctgcgagagt gtgtggttgc cctgtctgtc gtctgccggc cggcccggac cctggacacc     1260

atccagctgg ctttcaagat gtacggagcg caagaggacg gcagcgtcgg cgaaggtgac     1320

ctgtcctgca tcctcaagac ggccctgggg gtggcagagc tcaccgtgac cgacctattc     1380

cgagccattg accaagagga gaaggggaag atcacattcg ctgacttcca caggtttgca     1440

gaaatgtacc ctgccttcgc agaggaatac ctgtacccgg atcagacaca tttcgaaagc     1500

tgtgcagaga cctcacctgc gccaatccca aacggcttct gtgccgattt cagcccggaa     1560

aactcagacg ctgggcggaa gcctgttcgc aagaagctgg attag                     1605


<210>  256
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Arg Leu Arg Gly Cys Gly Pro Arg Ala Ala Pro Ala Ser Ser Ala 
1               5                   10                  15      


Gly Ala Ser Asp Ala Arg Leu Leu Ala Pro Pro Gly Arg Asn Pro Phe 
            20                  25                  30          


Val His Glu Leu Arg Leu Ser Ala Leu Gln Lys Ala Gln Val Ala Leu 
        35                  40                  45              


Met Thr Leu Thr Leu Phe Pro Val Arg Leu Leu Val Ala Ala Ala Met 
    50                  55                  60                  


Met Leu Leu Ala Trp Pro Leu Ala Leu Val Ala Ser Leu Gly Ser Ala 
65                  70                  75                  80  


Glu Lys Glu Pro Glu Gln Pro Pro Ala Leu Trp Arg Lys Val Val Asp 
                85                  90                  95      


Phe Leu Leu Lys Ala Ile Met Arg Thr Met Trp Phe Ala Gly Gly Phe 
            100                 105                 110         


His Arg Val Ala Val Lys Gly Arg Gln Ala Leu Pro Thr Glu Ala Ala 
        115                 120                 125             


Ile Leu Thr Leu Ala Pro His Ser Ser Tyr Phe Asp Ala Ile Pro Val 
    130                 135                 140                 


Thr Met Thr Met Ser Ser Ile Val Met Lys Ala Glu Ser Arg Asp Ile 
145                 150                 155                 160 


Pro Ile Trp Gly Thr Leu Ile Gln Tyr Ile Arg Pro Val Phe Val Ser 
                165                 170                 175     


Arg Ser Asp Gln Asp Ser Arg Arg Lys Thr Val Glu Glu Ile Lys Arg 
            180                 185                 190         


Arg Ala Gln Ser Asn Gly Lys Trp Pro Gln Ile Met Ile Phe Pro Glu 
        195                 200                 205             


Gly Thr Cys Thr Asn Arg Thr Cys Leu Ile Thr Phe Lys Pro Gly Ala 
    210                 215                 220                 


Phe Ile Pro Gly Ala Pro Val Gln Pro Val Val Leu Arg Tyr Pro Asn 
225                 230                 235                 240 


Lys Leu Asp Thr Ile Thr Trp Thr Trp Gln Gly Pro Gly Ala Leu Glu 
                245                 250                 255     


Ile Leu Trp Leu Thr Leu Cys Gln Phe His Asn Gln Val Glu Ile Glu 
            260                 265                 270         


Phe Leu Pro Val Tyr Ser Pro Ser Glu Glu Glu Lys Arg Asn Pro Ala 
        275                 280                 285             


Leu Tyr Ala Ser Asn Val Arg Arg Val Met Ala Glu Ala Leu Gly Val 
    290                 295                 300                 


Ser Val Thr Asp Tyr Thr Phe Glu Asp Cys Gln Leu Ala Leu Ala Glu 
305                 310                 315                 320 


Gly Gln Leu Arg Leu Pro Ala Asp Thr Cys Leu Leu Glu Phe Ala Arg 
                325                 330                 335     


Leu Val Arg Gly Leu Gly Leu Lys Pro Glu Lys Leu Glu Lys Asp Leu 
            340                 345                 350         


Asp Arg Tyr Ser Glu Arg Ala Arg Met Lys Gly Gly Glu Lys Ile Gly 
        355                 360                 365             


Ile Ala Glu Phe Ala Ala Ser Leu Glu Val Pro Val Ser Asp Leu Leu 
    370                 375                 380                 


Glu Asp Met Phe Ser Leu Phe Asp Glu Ser Gly Ser Gly Glu Val Asp 
385                 390                 395                 400 


Leu Arg Glu Cys Val Val Ala Leu Ser Val Val Cys Arg Pro Ala Arg 
                405                 410                 415     


Thr Leu Asp Thr Ile Gln Leu Ala Phe Lys Met Tyr Gly Ala Gln Glu 
            420                 425                 430         


Asp Gly Ser Val Gly Glu Gly Asp Leu Ser Cys Ile Leu Lys Thr Ala 
        435                 440                 445             


Leu Gly Val Ala Glu Leu Thr Val Thr Asp Leu Phe Arg Ala Ile Asp 
    450                 455                 460                 


Gln Glu Glu Lys Gly Lys Ile Thr Phe Ala Asp Phe His Arg Phe Ala 
465                 470                 475                 480 


Glu Met Tyr Pro Ala Phe Ala Glu Glu Tyr Leu Tyr Pro Asp Gln Thr 
                485                 490                 495     


His Phe Glu Ser Cys Ala Glu Thr Ser Pro Ala Pro Ile Pro Asn Gly 
            500                 505                 510         


Phe Cys Ala Asp Phe Ser Pro Glu Asn Ser Asp Ala Gly Arg Lys Pro 
        515                 520                 525             


Val Arg Lys Lys Leu Asp 
    530                 


<210>  257
<211>  9542
<212>  DNA
<213>  Homo sapiens

<400>  257
gcccttctcc agctactcgt ttgagagccg gtggcgttcc ggaggtttct ccctcgttat       60

ccccctgcct ttcacctgag gagaggctct gactgtctct ctctctctct ggcgtctgcg      120

cagcggggaa gtagtgagaa acaatcagag tacagagtat tttaatcttt aggggatcaa      180

gatgtcagat gcaaacaaag ctgccattgc agcagaaaag gaagctctga acttgaagtt      240

accccccatt gtccatctcc cagaaaacat aggcgttgat acaccaacac aaagtaagct      300

gctaaaatac agaagatcca aggagcagca gcagaaaatt aatcagttag taattgatgg      360

agccaaaaga aatttagaca gaacactggg taaaagaaca cctctattac caccacctga      420

ttatcctcaa actatgacca gtgaaatgaa aaaaaaagga ttcaactata tttatatgaa      480

gcaatgtgta gaaagtagtc ctttagtacc tattcagcag gaatggctgg atcacatgtt      540

aaggctgata cctgagtctt taaaggaagg gaaagaaaga gaagaacttc ttgaaagtct      600

cataaatgag gtgtcaagtg actttgaaaa cagcatgaag agatatttgg tgcagagcgt      660

tcttgtgaaa ccaccagtta aatcgcttga agatgaagga ggtcctttac ctgaatctcc      720

tgtaggccta gattattcta atccttggca ttctagctat gtgcaggcaa gaaatcaaat      780

attctctaat ttgcacatta ttcatccaac tatgaaaatg ttactggacc ttggttatac      840

aacatttgct gatacagttt tgttggactt cacaggaatt agagctaaag gtccaattga      900

ctgtgaatca ctgaaaactg atctatcaat acaaactaga aacgcagaag agaagataat      960

gaatacatgg tatccaaagg ttataaatct ctttaccaag aaggaggcac tagaaggtgt     1020

taaacctgaa aaattggatg cattttatag ctgtgtttcc acacttatgt caaatcagct     1080

aaaggatcta ttaaggagaa ctgtagaagg atttgtaaaa ctctttgacc caaaagatca     1140

acaaaggctg ccaatattta agatagaatt gacatttgat gacgacaaaa tggaatttta     1200

tcctaccttt caagatttgg aagataatgt cttgagtttg gtggaacgaa tagccgaagc     1260

tctgcagaat gtccaaacaa tcccctcttg gctatcagga acttcaacac cagtaaatct     1320

tgacacagaa cttcctgaac acgtgttaca ctgggctgtt gatacactga aggcagcagt     1380

acatcggaac ttagaaggtg caagaaagca ttatgagaca tatgttgaaa aatataattg     1440

gctccttgat gggactgcag ttgagaatat agagactttt cagacagaag atcatacttt     1500

tgatgaatat acagagttta tagaaaaatt tctcagtctt gcctcagaaa taatgctttt     1560

gcctcagtgg attcattaca ctatggtgcg tttggattgt gaagatttga agacaggcct     1620

gacaaataaa gcaaaagcct ttgcaaacat attattaaat gacatagctt caaaatatag     1680

aaaagaaaat gaatgtattt gcagtgaatt tgaagcaatt aaagaacatg cattaaaagt     1740

ccctgaaaca acagaagaga tgatggatct gatatcttat gtagaaaaag cccggactgt     1800

aggaatcgaa gagttgattt taaggatcca ggaatctaaa cgccaaatga gttacttttt     1860

agatgttttc ctatttcctc aagaagactt agctttaaat gcaactgtcc tcatgtggcc     1920

taggaaaatt aatcccatct ttgatgaaaa tgatgagcta attgagaatg ctaaacataa     1980

aaaagaaaat gaactaatgg ccaagagaga gaaacttatt ttggaaatag aaaaagaatc     2040

acgccgcatg gaggagttta cagaatttgc agagctggag cgcatgcaac agtatgtgac     2100

agatgtaaga caactacaaa aacgtattca ggaatctgaa gaagcagtgc agtttattaa     2160

taaagaagag gaacttttca agtgggaatt gacaaaatat cctgaactgg ataaattaaa     2220

agttaacatt gagccctatc agaagttttt taattttgtt ttgaagtggc agcgatcaga     2280

aaaacggtgg atggatggag ggtttttgga cctcaatggg gaaagcatgg aggctgatgt     2340

ggaagagttt tcccgagaaa tttttaagac actaaaattt ttccaaacga agctaaagaa     2400

agaattacaa gaaaaaagaa aggcagcaag aaaacggtct ttggaagaag agaaaattga     2460

agaagaacca aaagacaatg ctactattac tatgtgcaga atgagagctc gtcactggaa     2520

acagatatca gaaattgtag gctatgactt gactccagac tctggaacta cactgagaaa     2580

agttttaaaa ttaaacctta ccccatactt ggaacaattt gaagtgataa gtgcaggtgc     2640

aagcaaggaa ttttcattag agaaagccat gaatacaatg ataggaactt gggaagatat     2700

tgcttttcat ataagtctgt atcgtgacac tggagtctgt attctttctt cggtggatga     2760

gattcaggcc atccttgatg atcaaattat aaaaactcag acaatgagag gctcaccttt     2820

catcaaacca tttgaacatg agatcaaggc ctgggaggac cgcttgattc gaatacaaga     2880

aacaattgat gaatggttaa aagtacaagc tcaatggctg tacttagagc ccatcttttg     2940

ttctgaggat atcatgcaac agatgccaga agaagggcgt caatttcaga cagtagacag     3000

acactggaga gatatcatga agttttgtgc taaagatcca aaggttcttg ctgccacttc     3060

tttaacaggt ttattggaaa aactacagaa ctgcaatgaa cttttggaga aaattatgaa     3120

aggtcttaac gcatatcttg aaaagaaacg tcttttcttc cctcgttttt tcttcttatc     3180

taatgatgaa atgttagaga ttttatcaga gaccaaagat ccacttagag ttcagccaca     3240

tttaaaaaaa tgctttgagg gcattgctaa attagagttc cttcccaatt tggacattaa     3300

agccatgtat agctctgagg gcgagcgagt ggagctgatt gcactcattt ccacgtctgc     3360

agcgcggggt gctgtggaaa agtggctcat tcaagtggaa gacctaatgc tccggagtgt     3420

tcacgatgtg atcgctgcag ccaggctggc ttatccagaa tctgcaagaa gagactgggt     3480

tcgagagtgg cctggccaag ttgtactttg tatttctcaa atgttctgga catctgagac     3540

acaggaagtg ataagtggcg ggacggaggg attaaagaag tattataagg aacttcagaa     3600

ccaactgaat gagattgtag agctggtaag aggaaagttg tctaagcaga ccaggaccac     3660

tctgggggct ttggttacta ttgatgtcca tgctagagat gtggtcatgg acatgattaa     3720

aatgggtgtc tcacatgata cagatttcct gtggcttgct cagctccgat attattggga     3780

aaatgagaat gcccgagttc gtatcattaa ttgcaatgta aaatatgctt atgaatatct     3840

tggtaactca cctcgacttg tcattacgcc tctaactgac aggtgttaca gaacattgat     3900

aggtgctttc tatttaaacc ttggaggtgc tccagagggg ccagcaggca caggaaaaac     3960

cgaaaccacc aaggacttgg ctaaagctct tgctgtacag tgtgtggtgt tcaactgttc     4020

tgatgggcta gattatctag caatgggaaa gttttttaaa ggactggctt cttctggtgc     4080

ttgggcttgc tttgatgaat tcaatcgaat tgagttggaa gtgttgtcag tggtagctca     4140

acagatcctt tgcattcaga gagctattca acagaagttg gttgtgtttg tttttgaagg     4200

gacagaactt aagctcaatc cgaattgttt tgtagctatt accatgaatc ctggctatgc     4260

aggacgctct gaattgccgg acaatcttaa ggttcttttt agaacagtgg ctatgatggt     4320

tccaaactat gcgcttatag cagaaatctc cctctactct tacggatttt tgaatgcaag     4380

acctctgtct gtgaaaatag taatgaccta taggctttgc tcagagcagc tctcatcgca     4440

atttcattac gactatggaa tgcgagcagt aaaagccgtt ttagtggctg ctggcaatct     4500

aaaactaaaa tacccaaatg aaaatgaaga tatacttctt cttcgatcaa ttaaagatgt     4560

aaatgaacca aagtttttat cacatgatat acctttattt aatggaataa ctagtgactt     4620

atttcctggt attaaacttc ctgaagctga ctatcacgaa tttttggaat gtgctcatga     4680

agcctgcaat gtacataatc ttcagcctgt taaatttttt cttgaaaaaa taattcaaac     4740

atatgaaatg atgattgtta gacatggttt tatgttagta ggagagcctt ttgctgctaa     4800

gacaaaagtt ctgcatgtgc tggcggatac gctaacttta atgaatgaac atggctatgg     4860

agaggaagaa aaggtcattt atagaactgt aaaccccaaa tctattacta tgggccaact     4920

ttttggacag tttgacccag tgtctcatga gtggactgat ggtattgtgg ctaacacttt     4980

tagagaattt gccttatcag aaacacctga ccggaaatgg gttgtatttg atggtcctat     5040

tgacactttg tggatagaga gcatgaacac agtattggat gataataaaa agctttgcct     5100

tatgagtgga gaaatcattc agatgtcccc ccaaatgagc ctcatctttg aaacaatgga     5160

cctttcccag gcatcccctg ccactgtaag tcgttgtggt atgatttatt tggagccttc     5220

acagttagga tgggaaccac ttgtgtcttc ttggttgaat tcactgaaag gacctctgtg     5280

tgaaccagaa tatcaagctc ttctgagagg actttttgcc tggttaatac caccctcttt     5340

aaaccagcgg gttgaattat tccagctaaa ctatttgtat acaaccatag tgtctaaaat     5400

tttaaaaatt ctaattactt tccgtatttc aaattatttt aaatatgtgc ctctaaaaac     5460

tcaatgtaca tttattaaat tttttctcca ccaacaggct tgctttatat tctctttgat     5520

ttggtcgatt ggaggaagtt gtgatacaga tggccgtcgt gtttttgata ctttcatacg     5580

attaatcata ctgggaaaag atgatgaaaa cccagtgcca gattctgtgg gtaaatggga     5640

atgcccattt gatgaaaaag gcctggtcta tgactacatg tatgagttga aaaacaaagg     5700

tcgctgggtc cattggaatg aattaattaa aaatactaat ttaggagata aacaaatcaa     5760

gattcaagat atcatagtcc ctacgatgga cacaattaga tatacgtttc taatggattt     5820

gagtattacc tatgcaaagc cactcctttt tgtgggtcca acgggtacag gaaaatctgt     5880

gtatgtgaag gataagctaa tgaatcactt ggaaaaggac cagtactttc ctttttatat     5940

taacttatct gcacggacca gcgccaatca ggttcagaac attatcatgg ctagattgga     6000

taaaagacgc aaaggagtct ttggaccacc tatgggaaag aagtgtataa tttttataga     6060

tgatatgaat atgcctgcat tggagaagta tggagctcaa ccacctattg aattattacg     6120

acagtttttt gactgtggac attggtacga ccttaaggac acaagtaaaa tcacgctggt     6180

ggacatagag ctgattgctg caatgggccc tccaggtggt ggaagaaatc cagttactcc     6240

ccgttgtatt cgacatttca acatctgcag tattaattct tttagtgatg aaactatggt     6300

ccgaatcttc tcatctattg tagcattcta ccttagaact catgaatttc ctccagagta     6360

ctttgtaatt gggaaccaga tagtcaatgg gactatggag atatataaac aatctgtgga     6420

aaatctttta cccactccca caaaatccca ttatactttc aacttgcgtg atttttcacg     6480

cgtcatccgg ggctgtttac tcattgaaag agacgccgtg gcgaacaaac acactatgat     6540

ccgtctgttt gtgcatgagg ttctccgagt gttttatgat cgcctcatta atgatgatga     6600

tcgaagatgg ctgttccagt taactaaaac tgttataaag gaccatttta aagaatcatt     6660

tcacagtatc ttttcacatt tgaggaaaca aaatgcacca gtaactgaag aagacttaag     6720

aaatctcatg tttggtgatt atatgaatcc tgaccttgaa ggagatgata gagtttatat     6780

tgaaattcca aatattcatc attttagtga tgttgtggac cagtgcttag atgagtataa     6840

tcaaacacac aaaacaagaa tgaatcttgt catttttagg tatgttttgg aacatttatc     6900

aagaatatgt cgagttctaa agcaatctgg tggaaatgct ttgcttgttg gtcttggagg     6960

aagtggtcgt caatctttaa ctcgtctggc tacatccatg gcaaaaatgc atattttcca     7020

accagaaatt tctaagagct atggtatgaa tgaatggaga gaggatatga agagctttat     7080

tgctgtcccg gtgaccaaca ggatagtgga taacaaatcc aagattttgg aaaagcgcct     7140

acgatattta aatgaccact tcacatacaa cttatattgt aatatatgcc gatcactatt     7200

tgagaaggac aagctgttat tttccttttt attatgtgcc aatcttcttc tggcaaggaa     7260

agagattgaa taccaggaac tgatgtttct tttaactgga ggagtaagtc ttaaaagtgc     7320

tgagaaaaat cctgatccaa cttggctaca ggacaaaagc tgggaggaaa tctgtcgggc     7380

aagtgaattt cctgccttca gaggactcag gcaacatttt tgtgaacata tatatgaatg     7440

gcgagaaatc tatgacagta aagagccaca taatgctaaa tttccagcac caatggataa     7500

gaacctaaat gaactacaga aaataataat tcttcggtgt ttaagacctg ataagataac     7560

cccagctata acaaactatg taactgacaa actagggaaa aagtttgtag agcctccacc     7620

atttgatttg acaaagagtt acttggattc aaattgcacc attcccttaa tttttgttct     7680

atctccagga gcagatccta tggccagcct gctgaaattt gcaaatgata aatctatgtc     7740

tggaaataag tttcaagcta tttcactggg acagggacaa ggaccgattg cagcaaaaat     7800

gattaaagca gcaattgaag aaggaacttg ggtgtgccta cagaattgcc atcttgcagt     7860

gtcctggatg cccatgttgg aaaaaatatg tgaagatttt acctctgaaa cctgtaactc     7920

atcctttagg ctttggctga caagctatcc atcttcaaaa ttcccagtaa caattctaca     7980

gaatggagta aaaatgacta atgaacctcc cacgggtctt cggctgaatc tccttcaatc     8040

atatctcact gatccagttt ctgatcctga gtttttcaag ggatgccgtg gaaaggaact     8100

ggcctgggag aagttactgt ttggagtttg tttttttcat gcccttgtgc aagagagaaa     8160

gaaatttggt cctcttggtt ggaatattcc atatggattt aatgaatctg acttgcgcat     8220

cagtatccga caactgcagt tatttatcaa tgaatatgat acaattccat ttgaagctat     8280

atcttacctg actggggagt gtaattatgg aggaagagtg acagacgatt gggacagacg     8340

tcttctatta accatgctgg ctgactttta taatctgtac atagttgaaa accctcatta     8400

taagttttct cccagtggaa actattttgc acctcctaaa ggcacttatg aggactacat     8460

tgaattcatt aagaaacttc catttactca acaccctgag atatttggat tacatgaaaa     8520

cgttgacatc tccaaggatc ttcaacaaac aaaaaccctc tttgagtcct tgctcctcac     8580

ccagggaggc tccaaacaga caggagcctc aggaagtact gatcagattc tgttagaaat     8640

taccaaagat atcctcaaca agctccctag tgatttcgac attgaaatgg cactacggaa     8700

gtatcctgtg agatatgaag aaagcatgaa tactgtgtta gtacaagaaa tggaaagatt     8760

taacaattta attataacta tacgtaacac tctacgggac cttgaaaaag ctattaaggg     8820

tgtggttgtg atggattctg cattggaggc actctccggt agcttacttg ttggaaaggt     8880

tccagaaata tgggccaaac gttcataccc aagccttaag cccctgggaa gttacatcac     8940

agatttccta gcccggttga actttttaca ggactggtat aattcaggaa aaccttgtgt     9000

gttttggctg tcaggtttct ttttcactca ggccttttta actggagcta tgcagaatta     9060

tgccagaaaa tataccaccc ctattgattt gctaggatat gaatttgagg ttatcccatc     9120

tgatacatct gacacatcac cagaagatgg tgtttatatc cacggactgt atctcgatgg     9180

cgcacgctgg gaccgagaaa gtggattgct tgctgaacaa tatcccaaac ttctgtttga     9240

cctgatgccc atcatatgga taaaaccaac tcaaaaatct cggattataa agtcggatgc     9300

ctatgtctgt cccctctaca agacaagtga acgtaaagga actctttcca ctacgggaca     9360

ttctactaac tttgtcattg caatgttgtt aaaaacagac caacctactc ggcactggat     9420

caagcgcggg gttgctttgc tttgtcagtt ggatgactaa attggacaaa tttataaaac     9480

atccaaaagt ttaaaaaaaa aaaaacctgt cctacttaaa atatatacat tataaaacca     9540

ag                                                                    9542


<210>  258
<211>  3092
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ser Asp Ala Asn Lys Ala Ala Ile Ala Ala Glu Lys Glu Ala Leu 
1               5                   10                  15      


Asn Leu Lys Leu Pro Pro Ile Val His Leu Pro Glu Asn Ile Gly Val 
            20                  25                  30          


Asp Thr Pro Thr Gln Ser Lys Leu Leu Lys Tyr Arg Arg Ser Lys Glu 
        35                  40                  45              


Gln Gln Gln Lys Ile Asn Gln Leu Val Ile Asp Gly Ala Lys Arg Asn 
    50                  55                  60                  


Leu Asp Arg Thr Leu Gly Lys Arg Thr Pro Leu Leu Pro Pro Pro Asp 
65                  70                  75                  80  


Tyr Pro Gln Thr Met Thr Ser Glu Met Lys Lys Lys Gly Phe Asn Tyr 
                85                  90                  95      


Ile Tyr Met Lys Gln Cys Val Glu Ser Ser Pro Leu Val Pro Ile Gln 
            100                 105                 110         


Gln Glu Trp Leu Asp His Met Leu Arg Leu Ile Pro Glu Ser Leu Lys 
        115                 120                 125             


Glu Gly Lys Glu Arg Glu Glu Leu Leu Glu Ser Leu Ile Asn Glu Val 
    130                 135                 140                 


Ser Ser Asp Phe Glu Asn Ser Met Lys Arg Tyr Leu Val Gln Ser Val 
145                 150                 155                 160 


Leu Val Lys Pro Pro Val Lys Ser Leu Glu Asp Glu Gly Gly Pro Leu 
                165                 170                 175     


Pro Glu Ser Pro Val Gly Leu Asp Tyr Ser Asn Pro Trp His Ser Ser 
            180                 185                 190         


Tyr Val Gln Ala Arg Asn Gln Ile Phe Ser Asn Leu His Ile Ile His 
        195                 200                 205             


Pro Thr Met Lys Met Leu Leu Asp Leu Gly Tyr Thr Thr Phe Ala Asp 
    210                 215                 220                 


Thr Val Leu Leu Asp Phe Thr Gly Ile Arg Ala Lys Gly Pro Ile Asp 
225                 230                 235                 240 


Cys Glu Ser Leu Lys Thr Asp Leu Ser Ile Gln Thr Arg Asn Ala Glu 
                245                 250                 255     


Glu Lys Ile Met Asn Thr Trp Tyr Pro Lys Val Ile Asn Leu Phe Thr 
            260                 265                 270         


Lys Lys Glu Ala Leu Glu Gly Val Lys Pro Glu Lys Leu Asp Ala Phe 
        275                 280                 285             


Tyr Ser Cys Val Ser Thr Leu Met Ser Asn Gln Leu Lys Asp Leu Leu 
    290                 295                 300                 


Arg Arg Thr Val Glu Gly Phe Val Lys Leu Phe Asp Pro Lys Asp Gln 
305                 310                 315                 320 


Gln Arg Leu Pro Ile Phe Lys Ile Glu Leu Thr Phe Asp Asp Asp Lys 
                325                 330                 335     


Met Glu Phe Tyr Pro Thr Phe Gln Asp Leu Glu Asp Asn Val Leu Ser 
            340                 345                 350         


Leu Val Glu Arg Ile Ala Glu Ala Leu Gln Asn Val Gln Thr Ile Pro 
        355                 360                 365             


Ser Trp Leu Ser Gly Thr Ser Thr Pro Val Asn Leu Asp Thr Glu Leu 
    370                 375                 380                 


Pro Glu His Val Leu His Trp Ala Val Asp Thr Leu Lys Ala Ala Val 
385                 390                 395                 400 


His Arg Asn Leu Glu Gly Ala Arg Lys His Tyr Glu Thr Tyr Val Glu 
                405                 410                 415     


Lys Tyr Asn Trp Leu Leu Asp Gly Thr Ala Val Glu Asn Ile Glu Thr 
            420                 425                 430         


Phe Gln Thr Glu Asp His Thr Phe Asp Glu Tyr Thr Glu Phe Ile Glu 
        435                 440                 445             


Lys Phe Leu Ser Leu Ala Ser Glu Ile Met Leu Leu Pro Gln Trp Ile 
    450                 455                 460                 


His Tyr Thr Met Val Arg Leu Asp Cys Glu Asp Leu Lys Thr Gly Leu 
465                 470                 475                 480 


Thr Asn Lys Ala Lys Ala Phe Ala Asn Ile Leu Leu Asn Asp Ile Ala 
                485                 490                 495     


Ser Lys Tyr Arg Lys Glu Asn Glu Cys Ile Cys Ser Glu Phe Glu Ala 
            500                 505                 510         


Ile Lys Glu His Ala Leu Lys Val Pro Glu Thr Thr Glu Glu Met Met 
        515                 520                 525             


Asp Leu Ile Ser Tyr Val Glu Lys Ala Arg Thr Val Gly Ile Glu Glu 
    530                 535                 540                 


Leu Ile Leu Arg Ile Gln Glu Ser Lys Arg Gln Met Ser Tyr Phe Leu 
545                 550                 555                 560 


Asp Val Phe Leu Phe Pro Gln Glu Asp Leu Ala Leu Asn Ala Thr Val 
                565                 570                 575     


Leu Met Trp Pro Arg Lys Ile Asn Pro Ile Phe Asp Glu Asn Asp Glu 
            580                 585                 590         


Leu Ile Glu Asn Ala Lys His Lys Lys Glu Asn Glu Leu Met Ala Lys 
        595                 600                 605             


Arg Glu Lys Leu Ile Leu Glu Ile Glu Lys Glu Ser Arg Arg Met Glu 
    610                 615                 620                 


Glu Phe Thr Glu Phe Ala Glu Leu Glu Arg Met Gln Gln Tyr Val Thr 
625                 630                 635                 640 


Asp Val Arg Gln Leu Gln Lys Arg Ile Gln Glu Ser Glu Glu Ala Val 
                645                 650                 655     


Gln Phe Ile Asn Lys Glu Glu Glu Leu Phe Lys Trp Glu Leu Thr Lys 
            660                 665                 670         


Tyr Pro Glu Leu Asp Lys Leu Lys Val Asn Ile Glu Pro Tyr Gln Lys 
        675                 680                 685             


Phe Phe Asn Phe Val Leu Lys Trp Gln Arg Ser Glu Lys Arg Trp Met 
    690                 695                 700                 


Asp Gly Gly Phe Leu Asp Leu Asn Gly Glu Ser Met Glu Ala Asp Val 
705                 710                 715                 720 


Glu Glu Phe Ser Arg Glu Ile Phe Lys Thr Leu Lys Phe Phe Gln Thr 
                725                 730                 735     


Lys Leu Lys Lys Glu Leu Gln Glu Lys Arg Lys Ala Ala Arg Lys Arg 
            740                 745                 750         


Ser Leu Glu Glu Glu Lys Ile Glu Glu Glu Pro Lys Asp Asn Ala Thr 
        755                 760                 765             


Ile Thr Met Cys Arg Met Arg Ala Arg His Trp Lys Gln Ile Ser Glu 
    770                 775                 780                 


Ile Val Gly Tyr Asp Leu Thr Pro Asp Ser Gly Thr Thr Leu Arg Lys 
785                 790                 795                 800 


Val Leu Lys Leu Asn Leu Thr Pro Tyr Leu Glu Gln Phe Glu Val Ile 
                805                 810                 815     


Ser Ala Gly Ala Ser Lys Glu Phe Ser Leu Glu Lys Ala Met Asn Thr 
            820                 825                 830         


Met Ile Gly Thr Trp Glu Asp Ile Ala Phe His Ile Ser Leu Tyr Arg 
        835                 840                 845             


Asp Thr Gly Val Cys Ile Leu Ser Ser Val Asp Glu Ile Gln Ala Ile 
    850                 855                 860                 


Leu Asp Asp Gln Ile Ile Lys Thr Gln Thr Met Arg Gly Ser Pro Phe 
865                 870                 875                 880 


Ile Lys Pro Phe Glu His Glu Ile Lys Ala Trp Glu Asp Arg Leu Ile 
                885                 890                 895     


Arg Ile Gln Glu Thr Ile Asp Glu Trp Leu Lys Val Gln Ala Gln Trp 
            900                 905                 910         


Leu Tyr Leu Glu Pro Ile Phe Cys Ser Glu Asp Ile Met Gln Gln Met 
        915                 920                 925             


Pro Glu Glu Gly Arg Gln Phe Gln Thr Val Asp Arg His Trp Arg Asp 
    930                 935                 940                 


Ile Met Lys Phe Cys Ala Lys Asp Pro Lys Val Leu Ala Ala Thr Ser 
945                 950                 955                 960 


Leu Thr Gly Leu Leu Glu Lys Leu Gln Asn Cys Asn Glu Leu Leu Glu 
                965                 970                 975     


Lys Ile Met Lys Gly Leu Asn Ala Tyr Leu Glu Lys Lys Arg Leu Phe 
            980                 985                 990         


Phe Pro Arg Phe Phe Phe Leu Ser  Asn Asp Glu Met Leu  Glu Ile Leu 
        995                 1000                 1005             


Ser Glu  Thr Lys Asp Pro Leu  Arg Val Gln Pro His  Leu Lys Lys 
    1010                 1015                 1020             


Cys Phe  Glu Gly Ile Ala Lys  Leu Glu Phe Leu Pro  Asn Leu Asp 
    1025                 1030                 1035             


Ile Lys  Ala Met Tyr Ser Ser  Glu Gly Glu Arg Val  Glu Leu Ile 
    1040                 1045                 1050             


Ala Leu  Ile Ser Thr Ser Ala  Ala Arg Gly Ala Val  Glu Lys Trp 
    1055                 1060                 1065             


Leu Ile  Gln Val Glu Asp Leu  Met Leu Arg Ser Val  His Asp Val 
    1070                 1075                 1080             


Ile Ala  Ala Ala Arg Leu Ala  Tyr Pro Glu Ser Ala  Arg Arg Asp 
    1085                 1090                 1095             


Trp Val  Arg Glu Trp Pro Gly  Gln Val Val Leu Cys  Ile Ser Gln 
    1100                 1105                 1110             


Met Phe  Trp Thr Ser Glu Thr  Gln Glu Val Ile Ser  Gly Gly Thr 
    1115                 1120                 1125             


Glu Gly  Leu Lys Lys Tyr Tyr  Lys Glu Leu Gln Asn  Gln Leu Asn 
    1130                 1135                 1140             


Glu Ile  Val Glu Leu Val Arg  Gly Lys Leu Ser Lys  Gln Thr Arg 
    1145                 1150                 1155             


Thr Thr  Leu Gly Ala Leu Val  Thr Ile Asp Val His  Ala Arg Asp 
    1160                 1165                 1170             


Val Val  Met Asp Met Ile Lys  Met Gly Val Ser His  Asp Thr Asp 
    1175                 1180                 1185             


Phe Leu  Trp Leu Ala Gln Leu  Arg Tyr Tyr Trp Glu  Asn Glu Asn 
    1190                 1195                 1200             


Ala Arg  Val Arg Ile Ile Asn  Cys Asn Val Lys Tyr  Ala Tyr Glu 
    1205                 1210                 1215             


Tyr Leu  Gly Asn Ser Pro Arg  Leu Val Ile Thr Pro  Leu Thr Asp 
    1220                 1225                 1230             


Arg Cys  Tyr Arg Thr Leu Ile  Gly Ala Phe Tyr Leu  Asn Leu Gly 
    1235                 1240                 1245             


Gly Ala  Pro Glu Gly Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Thr 
    1250                 1255                 1260             


Lys Asp  Leu Ala Lys Ala Leu  Ala Val Gln Cys Val  Val Phe Asn 
    1265                 1270                 1275             


Cys Ser  Asp Gly Leu Asp Tyr  Leu Ala Met Gly Lys  Phe Phe Lys 
    1280                 1285                 1290             


Gly Leu  Ala Ser Ser Gly Ala  Trp Ala Cys Phe Asp  Glu Phe Asn 
    1295                 1300                 1305             


Arg Ile  Glu Leu Glu Val Leu  Ser Val Val Ala Gln  Gln Ile Leu 
    1310                 1315                 1320             


Cys Ile  Gln Arg Ala Ile Gln  Gln Lys Leu Val Val  Phe Val Phe 
    1325                 1330                 1335             


Glu Gly  Thr Glu Leu Lys Leu  Asn Pro Asn Cys Phe  Val Ala Ile 
    1340                 1345                 1350             


Thr Met  Asn Pro Gly Tyr Ala  Gly Arg Ser Glu Leu  Pro Asp Asn 
    1355                 1360                 1365             


Leu Lys  Val Leu Phe Arg Thr  Val Ala Met Met Val  Pro Asn Tyr 
    1370                 1375                 1380             


Ala Leu  Ile Ala Glu Ile Ser  Leu Tyr Ser Tyr Gly  Phe Leu Asn 
    1385                 1390                 1395             


Ala Arg  Pro Leu Ser Val Lys  Ile Val Met Thr Tyr  Arg Leu Cys 
    1400                 1405                 1410             


Ser Glu  Gln Leu Ser Ser Gln  Phe His Tyr Asp Tyr  Gly Met Arg 
    1415                 1420                 1425             


Ala Val  Lys Ala Val Leu Val  Ala Ala Gly Asn Leu  Lys Leu Lys 
    1430                 1435                 1440             


Tyr Pro  Asn Glu Asn Glu Asp  Ile Leu Leu Leu Arg  Ser Ile Lys 
    1445                 1450                 1455             


Asp Val  Asn Glu Pro Lys Phe  Leu Ser His Asp Ile  Pro Leu Phe 
    1460                 1465                 1470             


Asn Gly  Ile Thr Ser Asp Leu  Phe Pro Gly Ile Lys  Leu Pro Glu 
    1475                 1480                 1485             


Ala Asp  Tyr His Glu Phe Leu  Glu Cys Ala His Glu  Ala Cys Asn 
    1490                 1495                 1500             


Val His  Asn Leu Gln Pro Val  Lys Phe Phe Leu Glu  Lys Ile Ile 
    1505                 1510                 1515             


Gln Thr  Tyr Glu Met Met Ile  Val Arg His Gly Phe  Met Leu Val 
    1520                 1525                 1530             


Gly Glu  Pro Phe Ala Ala Lys  Thr Lys Val Leu His  Val Leu Ala 
    1535                 1540                 1545             


Asp Thr  Leu Thr Leu Met Asn  Glu His Gly Tyr Gly  Glu Glu Glu 
    1550                 1555                 1560             


Lys Val  Ile Tyr Arg Thr Val  Asn Pro Lys Ser Ile  Thr Met Gly 
    1565                 1570                 1575             


Gln Leu  Phe Gly Gln Phe Asp  Pro Val Ser His Glu  Trp Thr Asp 
    1580                 1585                 1590             


Gly Ile  Val Ala Asn Thr Phe  Arg Glu Phe Ala Leu  Ser Glu Thr 
    1595                 1600                 1605             


Pro Asp  Arg Lys Trp Val Val  Phe Asp Gly Pro Ile  Asp Thr Leu 
    1610                 1615                 1620             


Trp Ile  Glu Ser Met Asn Thr  Val Leu Asp Asp Asn  Lys Lys Leu 
    1625                 1630                 1635             


Cys Leu  Met Ser Gly Glu Ile  Ile Gln Met Ser Pro  Gln Met Ser 
    1640                 1645                 1650             


Leu Ile  Phe Glu Thr Met Asp  Leu Ser Gln Ala Ser  Pro Ala Thr 
    1655                 1660                 1665             


Val Ser  Arg Cys Gly Met Ile  Tyr Leu Glu Pro Ser  Gln Leu Gly 
    1670                 1675                 1680             


Trp Glu  Pro Leu Val Ser Ser  Trp Leu Asn Ser Leu  Lys Gly Pro 
    1685                 1690                 1695             


Leu Cys  Glu Pro Glu Tyr Gln  Ala Leu Leu Arg Gly  Leu Phe Ala 
    1700                 1705                 1710             


Trp Leu  Ile Pro Pro Ser Leu  Asn Gln Arg Val Glu  Leu Phe Gln 
    1715                 1720                 1725             


Leu Asn  Tyr Leu Tyr Thr Thr  Ile Val Ser Lys Ile  Leu Lys Ile 
    1730                 1735                 1740             


Leu Ile  Thr Phe Arg Ile Ser  Asn Tyr Phe Lys Tyr  Val Pro Leu 
    1745                 1750                 1755             


Lys Thr  Gln Cys Thr Phe Ile  Lys Phe Phe Leu His  Gln Gln Ala 
    1760                 1765                 1770             


Cys Phe  Ile Phe Ser Leu Ile  Trp Ser Ile Gly Gly  Ser Cys Asp 
    1775                 1780                 1785             


Thr Asp  Gly Arg Arg Val Phe  Asp Thr Phe Ile Arg  Leu Ile Ile 
    1790                 1795                 1800             


Leu Gly  Lys Asp Asp Glu Asn  Pro Val Pro Asp Ser  Val Gly Lys 
    1805                 1810                 1815             


Trp Glu  Cys Pro Phe Asp Glu  Lys Gly Leu Val Tyr  Asp Tyr Met 
    1820                 1825                 1830             


Tyr Glu  Leu Lys Asn Lys Gly  Arg Trp Val His Trp  Asn Glu Leu 
    1835                 1840                 1845             


Ile Lys  Asn Thr Asn Leu Gly  Asp Lys Gln Ile Lys  Ile Gln Asp 
    1850                 1855                 1860             


Ile Ile  Val Pro Thr Met Asp  Thr Ile Arg Tyr Thr  Phe Leu Met 
    1865                 1870                 1875             


Asp Leu  Ser Ile Thr Tyr Ala  Lys Pro Leu Leu Phe  Val Gly Pro 
    1880                 1885                 1890             


Thr Gly  Thr Gly Lys Ser Val  Tyr Val Lys Asp Lys  Leu Met Asn 
    1895                 1900                 1905             


His Leu  Glu Lys Asp Gln Tyr  Phe Pro Phe Tyr Ile  Asn Leu Ser 
    1910                 1915                 1920             


Ala Arg  Thr Ser Ala Asn Gln  Val Gln Asn Ile Ile  Met Ala Arg 
    1925                 1930                 1935             


Leu Asp  Lys Arg Arg Lys Gly  Val Phe Gly Pro Pro  Met Gly Lys 
    1940                 1945                 1950             


Lys Cys  Ile Ile Phe Ile Asp  Asp Met Asn Met Pro  Ala Leu Glu 
    1955                 1960                 1965             


Lys Tyr  Gly Ala Gln Pro Pro  Ile Glu Leu Leu Arg  Gln Phe Phe 
    1970                 1975                 1980             


Asp Cys  Gly His Trp Tyr Asp  Leu Lys Asp Thr Ser  Lys Ile Thr 
    1985                 1990                 1995             


Leu Val  Asp Ile Glu Leu Ile  Ala Ala Met Gly Pro  Pro Gly Gly 
    2000                 2005                 2010             


Gly Arg  Asn Pro Val Thr Pro  Arg Cys Ile Arg His  Phe Asn Ile 
    2015                 2020                 2025             


Cys Ser  Ile Asn Ser Phe Ser  Asp Glu Thr Met Val  Arg Ile Phe 
    2030                 2035                 2040             


Ser Ser  Ile Val Ala Phe Tyr  Leu Arg Thr His Glu  Phe Pro Pro 
    2045                 2050                 2055             


Glu Tyr  Phe Val Ile Gly Asn  Gln Ile Val Asn Gly  Thr Met Glu 
    2060                 2065                 2070             


Ile Tyr  Lys Gln Ser Val Glu  Asn Leu Leu Pro Thr  Pro Thr Lys 
    2075                 2080                 2085             


Ser His  Tyr Thr Phe Asn Leu  Arg Asp Phe Ser Arg  Val Ile Arg 
    2090                 2095                 2100             


Gly Cys  Leu Leu Ile Glu Arg  Asp Ala Val Ala Asn  Lys His Thr 
    2105                 2110                 2115             


Met Ile  Arg Leu Phe Val His  Glu Val Leu Arg Val  Phe Tyr Asp 
    2120                 2125                 2130             


Arg Leu  Ile Asn Asp Asp Asp  Arg Arg Trp Leu Phe  Gln Leu Thr 
    2135                 2140                 2145             


Lys Thr  Val Ile Lys Asp His  Phe Lys Glu Ser Phe  His Ser Ile 
    2150                 2155                 2160             


Phe Ser  His Leu Arg Lys Gln  Asn Ala Pro Val Thr  Glu Glu Asp 
    2165                 2170                 2175             


Leu Arg  Asn Leu Met Phe Gly  Asp Tyr Met Asn Pro  Asp Leu Glu 
    2180                 2185                 2190             


Gly Asp  Asp Arg Val Tyr Ile  Glu Ile Pro Asn Ile  His His Phe 
    2195                 2200                 2205             


Ser Asp  Val Val Asp Gln Cys  Leu Asp Glu Tyr Asn  Gln Thr His 
    2210                 2215                 2220             


Lys Thr  Arg Met Asn Leu Val  Ile Phe Arg Tyr Val  Leu Glu His 
    2225                 2230                 2235             


Leu Ser  Arg Ile Cys Arg Val  Leu Lys Gln Ser Gly  Gly Asn Ala 
    2240                 2245                 2250             


Leu Leu  Val Gly Leu Gly Gly  Ser Gly Arg Gln Ser  Leu Thr Arg 
    2255                 2260                 2265             


Leu Ala  Thr Ser Met Ala Lys  Met His Ile Phe Gln  Pro Glu Ile 
    2270                 2275                 2280             


Ser Lys  Ser Tyr Gly Met Asn  Glu Trp Arg Glu Asp  Met Lys Ser 
    2285                 2290                 2295             


Phe Ile  Ala Val Pro Val Thr  Asn Arg Ile Val Asp  Asn Lys Ser 
    2300                 2305                 2310             


Lys Ile  Leu Glu Lys Arg Leu  Arg Tyr Leu Asn Asp  His Phe Thr 
    2315                 2320                 2325             


Tyr Asn  Leu Tyr Cys Asn Ile  Cys Arg Ser Leu Phe  Glu Lys Asp 
    2330                 2335                 2340             


Lys Leu  Leu Phe Ser Phe Leu  Leu Cys Ala Asn Leu  Leu Leu Ala 
    2345                 2350                 2355             


Arg Lys  Glu Ile Glu Tyr Gln  Glu Leu Met Phe Leu  Leu Thr Gly 
    2360                 2365                 2370             


Gly Val  Ser Leu Lys Ser Ala  Glu Lys Asn Pro Asp  Pro Thr Trp 
    2375                 2380                 2385             


Leu Gln  Asp Lys Ser Trp Glu  Glu Ile Cys Arg Ala  Ser Glu Phe 
    2390                 2395                 2400             


Pro Ala  Phe Arg Gly Leu Arg  Gln His Phe Cys Glu  His Ile Tyr 
    2405                 2410                 2415             


Glu Trp  Arg Glu Ile Tyr Asp  Ser Lys Glu Pro His  Asn Ala Lys 
    2420                 2425                 2430             


Phe Pro  Ala Pro Met Asp Lys  Asn Leu Asn Glu Leu  Gln Lys Ile 
    2435                 2440                 2445             


Ile Ile  Leu Arg Cys Leu Arg  Pro Asp Lys Ile Thr  Pro Ala Ile 
    2450                 2455                 2460             


Thr Asn  Tyr Val Thr Asp Lys  Leu Gly Lys Lys Phe  Val Glu Pro 
    2465                 2470                 2475             


Pro Pro  Phe Asp Leu Thr Lys  Ser Tyr Leu Asp Ser  Asn Cys Thr 
    2480                 2485                 2490             


Ile Pro  Leu Ile Phe Val Leu  Ser Pro Gly Ala Asp  Pro Met Ala 
    2495                 2500                 2505             


Ser Leu  Leu Lys Phe Ala Asn  Asp Lys Ser Met Ser  Gly Asn Lys 
    2510                 2515                 2520             


Phe Gln  Ala Ile Ser Leu Gly  Gln Gly Gln Gly Pro  Ile Ala Ala 
    2525                 2530                 2535             


Lys Met  Ile Lys Ala Ala Ile  Glu Glu Gly Thr Trp  Val Cys Leu 
    2540                 2545                 2550             


Gln Asn  Cys His Leu Ala Val  Ser Trp Met Pro Met  Leu Glu Lys 
    2555                 2560                 2565             


Ile Cys  Glu Asp Phe Thr Ser  Glu Thr Cys Asn Ser  Ser Phe Arg 
    2570                 2575                 2580             


Leu Trp  Leu Thr Ser Tyr Pro  Ser Ser Lys Phe Pro  Val Thr Ile 
    2585                 2590                 2595             


Leu Gln  Asn Gly Val Lys Met  Thr Asn Glu Pro Pro  Thr Gly Leu 
    2600                 2605                 2610             


Arg Leu  Asn Leu Leu Gln Ser  Tyr Leu Thr Asp Pro  Val Ser Asp 
    2615                 2620                 2625             


Pro Glu  Phe Phe Lys Gly Cys  Arg Gly Lys Glu Leu  Ala Trp Glu 
    2630                 2635                 2640             


Lys Leu  Leu Phe Gly Val Cys  Phe Phe His Ala Leu  Val Gln Glu 
    2645                 2650                 2655             


Arg Lys  Lys Phe Gly Pro Leu  Gly Trp Asn Ile Pro  Tyr Gly Phe 
    2660                 2665                 2670             


Asn Glu  Ser Asp Leu Arg Ile  Ser Ile Arg Gln Leu  Gln Leu Phe 
    2675                 2680                 2685             


Ile Asn  Glu Tyr Asp Thr Ile  Pro Phe Glu Ala Ile  Ser Tyr Leu 
    2690                 2695                 2700             


Thr Gly  Glu Cys Asn Tyr Gly  Gly Arg Val Thr Asp  Asp Trp Asp 
    2705                 2710                 2715             


Arg Arg  Leu Leu Leu Thr Met  Leu Ala Asp Phe Tyr  Asn Leu Tyr 
    2720                 2725                 2730             


Ile Val  Glu Asn Pro His Tyr  Lys Phe Ser Pro Ser  Gly Asn Tyr 
    2735                 2740                 2745             


Phe Ala  Pro Pro Lys Gly Thr  Tyr Glu Asp Tyr Ile  Glu Phe Ile 
    2750                 2755                 2760             


Lys Lys  Leu Pro Phe Thr Gln  His Pro Glu Ile Phe  Gly Leu His 
    2765                 2770                 2775             


Glu Asn  Val Asp Ile Ser Lys  Asp Leu Gln Gln Thr  Lys Thr Leu 
    2780                 2785                 2790             


Phe Glu  Ser Leu Leu Leu Thr  Gln Gly Gly Ser Lys  Gln Thr Gly 
    2795                 2800                 2805             


Ala Ser  Gly Ser Thr Asp Gln  Ile Leu Leu Glu Ile  Thr Lys Asp 
    2810                 2815                 2820             


Ile Leu  Asn Lys Leu Pro Ser  Asp Phe Asp Ile Glu  Met Ala Leu 
    2825                 2830                 2835             


Arg Lys  Tyr Pro Val Arg Tyr  Glu Glu Ser Met Asn  Thr Val Leu 
    2840                 2845                 2850             


Val Gln  Glu Met Glu Arg Phe  Asn Asn Leu Ile Ile  Thr Ile Arg 
    2855                 2860                 2865             


Asn Thr  Leu Arg Asp Leu Glu  Lys Ala Ile Lys Gly  Val Val Val 
    2870                 2875                 2880             


Met Asp  Ser Ala Leu Glu Ala  Leu Ser Gly Ser Leu  Leu Val Gly 
    2885                 2890                 2895             


Lys Val  Pro Glu Ile Trp Ala  Lys Arg Ser Tyr Pro  Ser Leu Lys 
    2900                 2905                 2910             


Pro Leu  Gly Ser Tyr Ile Thr  Asp Phe Leu Ala Arg  Leu Asn Phe 
    2915                 2920                 2925             


Leu Gln  Asp Trp Tyr Asn Ser  Gly Lys Pro Cys Val  Phe Trp Leu 
    2930                 2935                 2940             


Ser Gly  Phe Phe Phe Thr Gln  Ala Phe Leu Thr Gly  Ala Met Gln 
    2945                 2950                 2955             


Asn Tyr  Ala Arg Lys Tyr Thr  Thr Pro Ile Asp Leu  Leu Gly Tyr 
    2960                 2965                 2970             


Glu Phe  Glu Val Ile Pro Ser  Asp Thr Ser Asp Thr  Ser Pro Glu 
    2975                 2980                 2985             


Asp Gly  Val Tyr Ile His Gly  Leu Tyr Leu Asp Gly  Ala Arg Trp 
    2990                 2995                 3000             


Asp Arg  Glu Ser Gly Leu Leu  Ala Glu Gln Tyr Pro  Lys Leu Leu 
    3005                 3010                 3015             


Phe Asp  Leu Met Pro Ile Ile  Trp Ile Lys Pro Thr  Gln Lys Ser 
    3020                 3025                 3030             


Arg Ile  Ile Lys Ser Asp Ala  Tyr Val Cys Pro Leu  Tyr Lys Thr 
    3035                 3040                 3045             


Ser Glu  Arg Lys Gly Thr Leu  Ser Thr Thr Gly His  Ser Thr Asn 
    3050                 3055                 3060             


Phe Val  Ile Ala Met Leu Leu  Lys Thr Asp Gln Pro  Thr Arg His 
    3065                 3070                 3075             


Trp Ile  Lys Arg Gly Val Ala  Leu Leu Cys Gln Leu  Asp Asp 
    3080                 3085                 3090         


<210>  259
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  259
atggcggccc aggggtgcgc ggcatcgcgg ctgctccagc tgctgctgca gcttctgctt       60

ctactgttgc tgctggcggc gggcggggcg cgcgcgcggt ggcgcgggga gggcaccagc      120

gcacacttgc gggacatctt cctgggccgc tgcgccgagt accgcgcact gctgagtccc      180

gagcagcgga acaagaactg cacagccatc tgggaagcct ttaaagtggc gctggacaag      240

gatccctgct ccgtgctgcc ctcagactat gaccttttta ttaacttgtc caggcactct      300

attcccagag ataagtccct gttctgggaa aatagccacc tccttgttaa cagctttgca      360

gacaacaccc gtcgttttat gcccctgagc gatgttctgt atggcagggt tgcagatttc      420

ttgagctggt gtcgacagaa aaatgactct ggactcgatt accaatcctg ccctacatca      480

gaagactgtg aaaataatcc tgtggattcc ttttggaaaa gggcatccat ccagtattcc      540

aaggatagtt ctggggtgat ccacgtcatg ctgaatggtt cagagccaac aggagcctat      600

cccatcaaag gtttttttgc agattatgaa attccaaacc tccagaagga aaaaattaca      660

cgaatcgaga tctgggttat gcatgaaatt gggggaccca atgtggaatc ctgcggggaa      720

ggcagcatga aagtcctgga aaagaggctg aaggacatgg ggttccagta cagctgtatt      780

aatgattacc gaccagtgaa gctcttacag tgcgtggacc acagcaccca tcctgactgt      840

gccttaaagt cggcagcagc cgctactcaa agaaaagccc caagtcttta tacagaacaa      900

agggcgggtc ttatcattcc cctctttctg gtgctggctt ccaggactca actgtaa         957


<210>  260
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  261
<211>  2813
<212>  DNA
<213>  Homo sapiens

<400>  261
gcgatcgcca tgagcgaagc cggcggccgg ggctgtgggt ccccggttcc ccagcgagcg       60

cgatggagac tagtggcggc gacggccgcg ttctgcctgg tgtcggccac ctccgtgtgg      120

acggcggggg ccgagcccat gagtagggag gagaaacaga agcttgggaa tcaagtactg      180

gaaatgtttg atcatgctta tggtaactat atggaacatg cttaccctgc tgatgaactc      240

atgcctttaa cctgtagagg tcgagttaga ggccaagagc caagtcgcgg tgacgttgat      300

gatgccttgg gaaaattttc tctgacactg attgattctt tggacactct tgtggtttta      360

aataaaacta aagaatttga agatgcagtg agaaaagttt taagagatgt taatttagat      420

aacgatgtag tcgtatcagt ctttgaaaca aacatcagag ttcttggggg tcttttgggt      480

gggcactccc tggcaatcat gctgaaagaa aaaggtgaat atatgcagtg gtacaatgat      540

gaacttctcc aaatggcaaa gcagttaggt tacaaacttt taccggcttt caacactacc      600

agtggccttc cttatccaag aattaattta aagtttggca tcagaaaacc agaagctcgg      660

acaggaactg agacagatac ctgtacagct tgtgcaggta ccttgatcct tgaatttgct      720

gctttaagtc gattcacagg agcaacaata tttgaggaat atgccagaaa agctcttgat      780

tttctctggg aaaaaagaca gcgaagtagt aatttagtgg gcgtgactat aaatattcat      840

actggagatt gggtacgaaa agatagtgga gttggagcag ggattgattc atattatgaa      900

tatctgttga aagcctatgt cttgcttgga gatgacagtt ttctggaaag atttaacaca      960

cactatgatg ccataatgag gtatattagc cagccacctc ttctacttga tgtgcatatc     1020

cacaaaccaa tgctgaatgc tcggacttgg atggatgctt tgcttgcctt cttcccaggc     1080

ttgcaggtgt taaaggggga tattagacct gctattgaaa ctcatgaaat gttatatcag     1140

gtgattaaaa aacacaattt tctaccagag gcatttacca cagatttcag agtacactgg     1200

gctcaacatc ctttaaggcc agaatttgca gaaagtacct acttcttata taaagctaca     1260

ggagatcctt actaccttga agtagggaag acacttattg aaaatttaaa taaatatgct     1320

agagtgcctt gcggatttgc tgccatgaag gatgttcgta ctggaagtca tgaggacaga     1380

atggattctt tcttcttggc tgaaatgttt aaatatcttt acctgttatt tgctgataaa     1440

gaagacatta tttttgacat agaagattac atctttacaa cagaagctca tctgttacct     1500

ctttggctct ctactacaaa tcaaagcatc tctaaaaaga acacaacctc ggaatataca     1560

gaactggatg acagtaactt cgattggact tgtccaaata ctcagatcct ctttcctaat     1620

gacccattgt atgctcaaag tattcgtgag cccttgaaaa atgtggtgga taagagctgt     1680

cctagaggca tcatcagagt agaggagagt ttcaggagtg gagctaaacc ccctctgaga     1740

gccagagatt tcatggccac taaccctgag catttagaaa tcctgaagaa gatgggggtg     1800

agtttgattc acctcaaaga tgggagagtc cagttggtcc aacatgcaat ccaagctgct     1860

agttcaatcg acgctgaaga tgggttgagg ttcatgcagg agatgattga attgtcaagt     1920

cagcaacaaa aagaacagca gctgcctcca cgagctgtac aaattgtttc ccacccattt     1980

tttggcaggg tagtattgac tgctggacca gctcagtttg ggctggatct gtctaaacat     2040

aaagagacaa gaggatttgt tgcaagcagt aaaccatcca atggttgttc agagcttact     2100

aacccagagg cagtgatggg aaaaatcgca ctgatacaaa gaggacagtg catgtttgca     2160

gaaaaggcac gcaacatcca gaatgctgga gccattggtg gcattgttat tgatgacaat     2220

gaggggagca gcagtgatac tgcccctctg ttccagatgg caggtgatgg aaaggataca     2280

gatgacatca agatccccat gctgttctta ttcagcaaag aaggaagtat catactggat     2340

gccatccggg aatatgagga ggtagaagtg ctcctctctg ataaagcaaa agatcgagat     2400

cctgaaatgg aaaatgaaga acaaccatcc tctgaaaatg attctcagaa tcagagtggt     2460

gaacagattt catcaagttc tcaggaggtt gatttggttg atcaagagtc ttctgaggaa     2520

aattctctaa attctcaccc agaatcatta tctctagcag atatggacaa tgctgcaagc     2580

atttcccctt ctgaacagac ttctaatccc acagaaaacc atgagactac aaatcttaat     2640

ggtgaatgta cagatttaga taaccagctt caagaacaat cagaaactga ggaagattcc     2700

aatcctaatg ttagctgggg taaaaaggtc cagcctatag actccatatt agcagactgg     2760

aatgaagata tagaagcatt tgaaatgatg gagaaggatg agctagttta aac            2813


<210>  262
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg 
1               5                   10                  15      


Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser 
            20                  25                  30          


Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu 
        35                  40                  45              


Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met Phe Asp His Ala Tyr 
    50                  55                  60                  


Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp Glu Leu Met Pro Leu 
65                  70                  75                  80  


Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro Ser Arg Gly Asp Val 
                85                  90                  95      


Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu Ile Asp Ser Leu Asp 
            100                 105                 110         


Thr Leu Val Val Leu Asn Lys Thr Lys Glu Phe Glu Asp Ala Val Arg 
        115                 120                 125             


Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp Val Val Val Ser Val 
    130                 135                 140                 


Phe Glu Thr Asn Ile Arg Val Leu Gly Gly Leu Leu Gly Gly His Ser 
145                 150                 155                 160 


Leu Ala Ile Met Leu Lys Glu Lys Gly Glu Tyr Met Gln Trp Tyr Asn 
                165                 170                 175     


Asp Glu Leu Leu Gln Met Ala Lys Gln Leu Gly Tyr Lys Leu Leu Pro 
            180                 185                 190         


Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro Arg Ile Asn Leu Lys 
        195                 200                 205             


Phe Gly Ile Arg Lys Pro Glu Ala Arg Thr Gly Thr Glu Thr Asp Thr 
    210                 215                 220                 


Cys Thr Ala Cys Ala Gly Thr Leu Ile Leu Glu Phe Ala Ala Leu Ser 
225                 230                 235                 240 


Arg Phe Thr Gly Ala Thr Ile Phe Glu Glu Tyr Ala Arg Lys Ala Leu 
                245                 250                 255     


Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser Asn Leu Val Gly Val 
            260                 265                 270         


Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg Lys Asp Ser Gly Val 
        275                 280                 285             


Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu Leu Lys Ala Tyr Val 
    290                 295                 300                 


Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe Asn Thr His Tyr Asp 
305                 310                 315                 320 


Ala Ile Met Arg Tyr Ile Ser Gln Pro Pro Leu Leu Leu Asp Val His 
                325                 330                 335     


Ile His Lys Pro Met Leu Asn Ala Arg Thr Trp Met Asp Ala Leu Leu 
            340                 345                 350         


Ala Phe Phe Pro Gly Leu Gln Val Leu Lys Gly Asp Ile Arg Pro Ala 
        355                 360                 365             


Ile Glu Thr His Glu Met Leu Tyr Gln Val Ile Lys Lys His Asn Phe 
    370                 375                 380                 


Leu Pro Glu Ala Phe Thr Thr Asp Phe Arg Val His Trp Ala Gln His 
385                 390                 395                 400 


Pro Leu Arg Pro Glu Phe Ala Glu Ser Thr Tyr Phe Leu Tyr Lys Ala 
                405                 410                 415     


Thr Gly Asp Pro Tyr Tyr Leu Glu Val Gly Lys Thr Leu Ile Glu Asn 
            420                 425                 430         


Leu Asn Lys Tyr Ala Arg Val Pro Cys Gly Phe Ala Ala Met Lys Asp 
        435                 440                 445             


Val Arg Thr Gly Ser His Glu Asp Arg Met Asp Ser Phe Phe Leu Ala 
    450                 455                 460                 


Glu Met Phe Lys Tyr Leu Tyr Leu Leu Phe Ala Asp Lys Glu Asp Ile 
465                 470                 475                 480 


Ile Phe Asp Ile Glu Asp Tyr Ile Phe Thr Thr Glu Ala His Leu Leu 
                485                 490                 495     


Pro Leu Trp Leu Ser Thr Thr Asn Gln Ser Ile Ser Lys Lys Asn Thr 
            500                 505                 510         


Thr Ser Glu Tyr Thr Glu Leu Asp Asp Ser Asn Phe Asp Trp Thr Cys 
        515                 520                 525             


Pro Asn Thr Gln Ile Leu Phe Pro Asn Asp Pro Leu Tyr Ala Gln Ser 
    530                 535                 540                 


Ile Arg Glu Pro Leu Lys Asn Val Val Asp Lys Ser Cys Pro Arg Gly 
545                 550                 555                 560 


Ile Ile Arg Val Glu Glu Ser Phe Arg Ser Gly Ala Lys Pro Pro Leu 
                565                 570                 575     


Arg Ala Arg Asp Phe Met Ala Thr Asn Pro Glu His Leu Glu Ile Leu 
            580                 585                 590         


Lys Lys Met Gly Val Ser Leu Ile His Leu Lys Asp Gly Arg Val Gln 
        595                 600                 605             


Leu Val Gln His Ala Ile Gln Ala Ala Ser Ser Ile Asp Ala Glu Asp 
    610                 615                 620                 


Gly Leu Arg Phe Met Gln Glu Met Ile Glu Leu Ser Ser Gln Gln Gln 
625                 630                 635                 640 


Lys Glu Gln Gln Leu Pro Pro Arg Ala Val Gln Ile Val Ser His Pro 
                645                 650                 655     


Phe Phe Gly Arg Val Val Leu Thr Ala Gly Pro Ala Gln Phe Gly Leu 
            660                 665                 670         


Asp Leu Ser Lys His Lys Glu Thr Arg Gly Phe Val Ala Ser Ser Lys 
        675                 680                 685             


Pro Ser Asn Gly Cys Ser Glu Leu Thr Asn Pro Glu Ala Val Met Gly 
    690                 695                 700                 


Lys Ile Ala Leu Ile Gln Arg Gly Gln Cys Met Phe Ala Glu Lys Ala 
705                 710                 715                 720 


Arg Asn Ile Gln Asn Ala Gly Ala Ile Gly Gly Ile Val Ile Asp Asp 
                725                 730                 735     


Asn Glu Gly Ser Ser Ser Asp Thr Ala Pro Leu Phe Gln Met Ala Gly 
            740                 745                 750         


Asp Gly Lys Asp Thr Asp Asp Ile Lys Ile Pro Met Leu Phe Leu Phe 
        755                 760                 765             


Ser Lys Glu Gly Ser Ile Ile Leu Asp Ala Ile Arg Glu Tyr Glu Glu 
    770                 775                 780                 


Val Glu Val Leu Leu Ser Asp Lys Ala Lys Asp Arg Asp Pro Glu Met 
785                 790                 795                 800 


Glu Asn Glu Glu Gln Pro Ser Ser Glu Asn Asp Ser Gln Asn Gln Ser 
                805                 810                 815     


Gly Glu Gln Ile Ser Ser Ser Ser Gln Glu Val Asp Leu Val Asp Gln 
            820                 825                 830         


Glu Ser Ser Glu Glu Asn Ser Leu Asn Ser His Pro Glu Ser Leu Ser 
        835                 840                 845             


Leu Ala Asp Met Asp Asn Ala Ala Ser Ile Ser Pro Ser Glu Gln Thr 
    850                 855                 860                 


Ser Asn Pro Thr Glu Asn His Glu Thr Thr Asn Leu Asn Gly Glu Cys 
865                 870                 875                 880 


Thr Asp Leu Asp Asn Gln Leu Gln Glu Gln Ser Glu Thr Glu Glu Asp 
                885                 890                 895     


Ser Asn Pro Asn Val Ser Trp Gly Lys Lys Val Gln Pro Ile Asp Ser 
            900                 905                 910         


Ile Leu Ala Asp Trp Asn Glu Asp Ile Glu Ala Phe Glu Met Met Glu 
        915                 920                 925             


Lys Asp Glu Leu 
    930         


<210>  263
<211>  7718
<212>  DNA
<213>  Homo sapiens

<400>  263
caagaaggga ccgggcgatg gcagcagggg agccccgcgg gcgcgcgtcc tcgggagtgg       60

cgccgtgaca cgcatggttt ccccggaccc gcggcggcgc tgacttccgc gagtcggagc      120

ggcactcggc gagtccggga ctgcgctgga acaatggata acttcttcac cgagggaaca      180

cgggtctggc tgagagaaaa tggccagcat tttccaagta ctgtaaattc ctgtgcagaa      240

ggcatcgtcg tcttccggac agactatggt caggtattca cttacaagca gagcacaatt      300

acccaccaga aggtgactgc tatgcacccc acgaacgagg agggcgtgga tgacatggcg      360

tccttgacag agctccatgg cggctccatc atgtataact tattccagcg gtataagaga      420

aatcaaatat atacctacat cggctccatc ctggcctccg tgaaccccta ccagcccatc      480

gccgggctgt acgagcctgc caccatggag cagtacagcc ggcgccacct gggcgagctg      540

cccccgcaca tcttcgccat cgccaacgag tgctaccgct gcctgtggaa gcgccacgac      600

aaccagtgca tcctcatcag tggtgaaagt ggggcaggta aaaccgaaag cactaaattg      660

atcctcaagt ttctgtcagt catcagtcaa cagtctttgg aattgtcctt aaaggagaag      720

acatcctgtg ttgaacgagc tattcttgaa agcagcccca tcatggaagc tttcggcaat      780

gcgaagaccg tgtacaacaa caactctagt cgctttggga agtttgttca gctgaacatc      840

tgtcagaaag gaaatattca gggcgggaga attgtagatt atttattaga aaaaaaccga      900

gtagtaaggc aaaatccctg ggaaaggaat tatcacatat tttatgcact gctggcaggg      960

ctggaacatg aagaaagaga agaattttat ttatctacgc cagaaaacta ccactacttg     1020

aatcagtctg gatgtgtaga agacaagaca atcagtgacc aggaatcctt tagggaagtt     1080

attacggcaa tggacgtgat gcagttcagc aaggaggaag tttgggaagt gtcgaggctg     1140

cttgctggta tactgcatct tgggaacata gaatttatca ctgctggtgg ggcacaggtt     1200

tccttcaaaa cagctttggg cagatctgcg gagttacttg ggctggaccc aacacagctc     1260

acagatgctt tgacccagag atcaatgttc ctcaggggag aagagatcct cacgcctctc     1320

aatgttcaac aggcagtaga cagcagggac tccctggcca tggctctgta tgcgtgctgc     1380

tttgagtggg taatcaagaa gatcaacagc aggatcaaag gcaatgagga cttcaagtct     1440

attggcatcc tcgacatctt tggatttgaa aactttgagg ttaatcactt tgaacagttc     1500

aatataaact atgcaaacga gaaacttcag gagtacttca acaagcatat tttttcttta     1560

gaacaactag aatatagccg ggaaggatta gtgtgggaag atattgactg gatagacaat     1620

ggagaatgcc tggacttgat tgagaagaaa cttggcctcc tagcccttat caatgaagaa     1680

agccattttc ctcaagccac agacagcacc ttattggaga agctacacag tcagcatgcg     1740

aataaccact tttatgtgaa gcccagagtt gcagttaaca attttggagt gaagcactat     1800

gctggagagg tgcaatatga tgtccgaggt atcttggaga agaacagaga tacatttcga     1860

gatgaccttc tcaatttgct aagagaaagc cgatttgact ttatctacga tctttttgaa     1920

catgtttcaa gccgcaacaa ccaggatacc ttgaaatgtg gaagcaaaca tcggcggcct     1980

acagtcagct cacagttcaa ggactcactg cattccttaa tggcaacgct aagctcctct     2040

aatcctttct ttgttcgctg tatcaagcca aacatgcaga agatgccaga ccagtttgac     2100

caggcggttg tgctgaacca gctgcggtac tcagggatgc tggagactgt gagaatccgc     2160

aaagctgggt atgcggtccg aagacccttt caggactttt acaaaaggta taaagtgctg     2220

atgaggaatc tggctctgcc tgaggacgtc cgagggaagt gcacgagcct gctgcagctc     2280

tatgatgcct ccaacagcga gtggcagctg gggaagacca aggtctttct tcgagaatcc     2340

ttggaacaga aactggagaa gcggagggaa gaggaagtga gccacgcggc catggtgatt     2400

cgggcccatg tcttgggctt cttagcacga aaacaataca gaaaggtcct ttattgtgtg     2460

gtgataatac agaagaatta cagagcattc cttctgagga ggagattttt gcacctgaaa     2520

aaggcagcca tagttttcca gaagcaactc agaggtcaga ttgctcggag agtttacaga     2580

caattgctgg cagagaaaag ggagcaagaa gaaaagaaga aacaggaaga ggaagaaaag     2640

aagaaacggg aggaagaaga aagagaaaga gagagagagc gaagagaagc cgagctccgc     2700

gcccagcagg aagaagaaac gaggaagcag caagaactcg aagccttgca gaagagccag     2760

aaggaagctg aactgacccg tgaactggag aaacagaagg aaaataagca ggtggaagag     2820

atcctccgtc tggagaaaga aatcgaggac ctgcagcgca tgaaggagca gcaggagctg     2880

tcgctgaccg aggcttccct gcagaagctg caggagcggc gggaccagga gctccgcagg     2940

ctggaggagg aagcgtgcag ggcggcccag gagttcctcg agtccctcaa tttcgacgag     3000

atcgacgagt gtgtccggaa tatcgagcgg tccctgtcgg tgggaagcga attttccagc     3060

gagctggctg agagcgcatg cgaggagaag cccaacttca acttcagcca gccctaccca     3120

gaggaggagg tcgatgaggg cttcgaagcc gacgacgacg ccttcaagga ctcccccaac     3180

cccagcgagc acggccactc agaccagcga acaagtggca tccggaccag cgatgactct     3240

tcagaggagg acccatacat gaacgacacg gtggtgccca ccagccccag tgcggacagc     3300

acggtgctgc tcgccccatc agtgcaggac tccgggagcc tacacaactc ctccagcggc     3360

gagtccacct actgcatgcc ccagaacgct ggggacttgc cctccccaga cggcgactac     3420

gactacgacc aggatgacta tgaggacggt gccatcactt ccggcagcag cgtgaccttc     3480

tccaactcct acggcagcca gtggtccccc gactaccgct gctctgtggg gacctacaac     3540

agctcgggtg cctaccggtt cagctctgag ggggcgcagt cctcgtttga agatagtgaa     3600

gaggactttg attccaggtt tgatacagat gatgagcttt cataccggcg tgactctgtg     3660

tacagctgtg tcactctgcc gtatttccac agctttctgt acatgaaagg tggcctgatg     3720

aactcttgga aacgccgctg gtgcgtcctc aaggatgaaa ccttcttgtg gttccgctcc     3780

aagcaggagg ccctcaagca aggctggctc cacaaaaaag gggggggctc ctccacgctg     3840

tccaggagaa attggaagaa gcgctggttt gtcctccgcc agtccaagct gatgtacttt     3900

gaaaacgaca gcgaggagaa gctcaagggc accgtagaag tgcgaacggc aaaagagatc     3960

atagataaca ccaccaagga gaatgggatc gacatcatta tggccgatag gactttccac     4020

ctgattgcag agtccccaga agatgccagc cagtggttca gcgtgctgag tcaggtccac     4080

gcgtccacgg accaggagat ccaggagatg catgatgagc aggcaaaccc acagaatgct     4140

gtgggcacct tggatgtggg gctgattgat tctgtgtgtg cctctgacag ccctgataga     4200

cccaactcgt ttgtgatcat cacggccaac cgggtgctgc actgcaacgc cgacacgccg     4260

gaggagatgc accactggat aaccctgctg cagaggtcca aaggggacac cagagtggag     4320

ggccaggaat tcatcgtgag aggatggttg cacaaagagg tgaagaacag tccaaagatg     4380

tcttcactga aactgaagaa acggtggttt gtactcaccc acaattccct ggattactac     4440

aagagttcag agaagaacgc gctcaaactg gggaccctgg tcctcaacag cctctgctct     4500

gtcgtccccc cagatgagaa gatattcaaa gagacaggct actggaacgt caccgtgtac     4560

gggcgcaagc actgttaccg gctctacacc aagctgctca acgaggccac ccggtggtcc     4620

agtgccattc aaaacgtgac tgacaccaag gccccgatcg acacccccac ccagcagctg     4680

attcaagata tcaaggagaa ctgcctgaac tcggatgtgg tggaacagat ttacaagcgg     4740

aacccgatcc ttcgatacac ccatcacccc ttgcactccc cgctcctgcc ccttccgtat     4800

ggggacataa atctcaactt gctcaaagac aaaggctata ccacccttca ggatgaggcc     4860

atcaagatat tcaattccct gcagcaactg gagtccatgt ctgacccaat tccaataatc     4920

cagggcatcc tacagacagg gcatgacctg cgacctctgc gggacgagct gtactgccag     4980

cttatcaaac agaccaacaa agtgccccac cccggcagtg tgggcaacct gtacagctgg     5040

cagatcctga catgcctgag ctgcaccttc ctgccgagtc gagggattct caagtatctc     5100

aagttccatc tgaaaaggat acgggaacag tttccaggaa ccgagatgga aaaatacgct     5160

ctcttcactt acgaatctct taagaaaacc aaatgccgag agtttgtgcc ttcccgagat     5220

gaaatagaag ctctgatcca caggcaggaa atgacatcca cggtctattg ccatggcggc     5280

ggctcctgca agatcaccat caactcccac accaccgctg gggaggtggt ggagaagctg     5340

atccgaggcc tggccatgga ggacagcagg aacatgtttg ctttgtttga atacaacggc     5400

cacgtcgaca aagccattga aagtcgaacc gtcgtagctg atgtcttagc caagtttgaa     5460

aagctggctg ccacatccga ggttggggac ctgccatgga aattctactt caaactttac     5520

tgcttcctgg acacagacaa cgtgccaaaa gacagtgtgg agtttgcatt tatgtttgaa     5580

caggcccacg aagcggttat ccatggccac catccagccc cggaagaaaa cctccaggtt     5640

cttgctgccc tgcgactcca gtatctgcag ggggattata ctctgcacgc tgccatccca     5700

cctctcgaag aggtttattc cctgcagaga ctcaaggccc gcatcagcca gtcaaccaaa     5760

accttcaccc cttgtgaacg gctggagaag aggcggacga gcttcctaga ggggaccctg     5820

aggcggagct tccggacagg atccgtggtc cggcagaagg tcgaggagga gcagatgctg     5880

gacatgtgga ttaaggaaga agtctcctct gctcgagcca gtatcattga caagtggagg     5940

aaatttcagg gaatgaacca ggaacaggcc atggccaagt acatggcctt gatcaaggag     6000

tggcctggct atggctcgac gctgtttgat gtggagtgca aggaaggtgg cttccctcag     6060

gaactctggt tgggtgtcag cgcggacgcc gtctccgtct acaagcgtgg agagggaaga     6120

ccactggaag tcttccagta tgaacacatc ctctcttttg gggcacccct ggcgaatacg     6180

tataagatcg tggtcgatga gagggagctg ctctttgaaa ccagtgaggt ggtggatgtg     6240

gccaagctca tgaaagccta catcagcatg atcgtgaaga agcgctacag cacgacacgc     6300

tccgccagca gccagggcag ctccaggtga aggcgggaca gagcccacct gtctttgcta     6360

cctgaacgca ccaccctctg gcctaggctg gctccagtgt gccatgccca gccaaaacaa     6420

acacagagct gcccaggctt tctggaagct tctggtctga gggaggtgtc tccgaggatc     6480

cttttgcctg ccgccttcat tgatcctgta ttaagctgtc aactttaaca gtctgcacag     6540

tttccaaagc tttactactc ttagaggaca catgccttaa aaaaggaggg gaggaaccac     6600

gctgccacca aagcagccgg aagtgcctta acttgtggaa ccaacactaa tcgaccgtaa     6660

ctgtgctact gaagggaact gcctttcccc cttctggggg agacttaaca gagcgtggaa     6720

ggggggcatt ctctgtcaat gatgcactaa cctcccaacc tgatttcccc gaatctgagg     6780

gaaggtgagg gagtgggaag ggggatggag agctcgaggg gacagtgtgt ttgagctgga     6840

gtgctgcggg cagcctttct catggaatga catgaatcaa cttttttctt tgtttcatct     6900

tttaagtgta cgtgcttgcc tgttcgtgca tgtgttcata aactcaacac cttaatcatg     6960

gtttcatgag cattaaaaag caaagggaaa aaggatgtgt aatggtgtac acagtctgta     7020

tattttaata atgcagagct atagtctcaa ttgttacttt ataaggtggt tttattaaca     7080

aacccaaatc ctggattttc ctgtctttgc tgtattttga aaaacacgtg ttgactccat     7140

tgttttacat gtagcaaagt ctgccatctg tgtctgctgt attataaaca gataagcagc     7200

ctacaagata actgtattta taaaccactc ttcaacagct ggctccagtg ctggttttag     7260

aacaagaatg aagtcatttt ggagtctttc atgtctaaaa gatttaagtt aaaaacaaag     7320

tgttacttgg aaggttagct tctatcattc tggatagatt acagatataa taaccatgtt     7380

gactatgggg gagagacgct gcattccaga aacgtcttaa cacttgagtg aatcttcaaa     7440

ggaccctgac attaaatgct gaggctttaa tacacacata ttttatccca agtttataat     7500

ggtggtctga acaaggcacc tgtaaataaa tcagcattta tgaccagaag aaaaataatc     7560

tggtcttgga ctttttattt ttatatggaa aagttttaag gacttgggcc aactaagtct     7620

acccacacga aaaaagaaat ttgccttgtc cctttgtgta caaccatgca aaactgtttg     7680

ttggctcaca gaagttctga caataaaaga tactagct                             7718


<210>  264
<211>  2058
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Asp Asn Phe Phe Thr Glu Gly Thr Arg Val Trp Leu Arg Glu Asn 
1               5                   10                  15      


Gly Gln His Phe Pro Ser Thr Val Asn Ser Cys Ala Glu Gly Ile Val 
            20                  25                  30          


Val Phe Arg Thr Asp Tyr Gly Gln Val Phe Thr Tyr Lys Gln Ser Thr 
        35                  40                  45              


Ile Thr His Gln Lys Val Thr Ala Met His Pro Thr Asn Glu Glu Gly 
    50                  55                  60                  


Val Asp Asp Met Ala Ser Leu Thr Glu Leu His Gly Gly Ser Ile Met 
65                  70                  75                  80  


Tyr Asn Leu Phe Gln Arg Tyr Lys Arg Asn Gln Ile Tyr Thr Tyr Ile 
                85                  90                  95      


Gly Ser Ile Leu Ala Ser Val Asn Pro Tyr Gln Pro Ile Ala Gly Leu 
            100                 105                 110         


Tyr Glu Pro Ala Thr Met Glu Gln Tyr Ser Arg Arg His Leu Gly Glu 
        115                 120                 125             


Leu Pro Pro His Ile Phe Ala Ile Ala Asn Glu Cys Tyr Arg Cys Leu 
    130                 135                 140                 


Trp Lys Arg His Asp Asn Gln Cys Ile Leu Ile Ser Gly Glu Ser Gly 
145                 150                 155                 160 


Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Lys Phe Leu Ser Val 
                165                 170                 175     


Ile Ser Gln Gln Ser Leu Glu Leu Ser Leu Lys Glu Lys Thr Ser Cys 
            180                 185                 190         


Val Glu Arg Ala Ile Leu Glu Ser Ser Pro Ile Met Glu Ala Phe Gly 
        195                 200                 205             


Asn Ala Lys Thr Val Tyr Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe 
    210                 215                 220                 


Val Gln Leu Asn Ile Cys Gln Lys Gly Asn Ile Gln Gly Gly Arg Ile 
225                 230                 235                 240 


Val Asp Tyr Leu Leu Glu Lys Asn Arg Val Val Arg Gln Asn Pro Trp 
                245                 250                 255     


Glu Arg Asn Tyr His Ile Phe Tyr Ala Leu Leu Ala Gly Leu Glu His 
            260                 265                 270         


Glu Glu Arg Glu Glu Phe Tyr Leu Ser Thr Pro Glu Asn Tyr His Tyr 
        275                 280                 285             


Leu Asn Gln Ser Gly Cys Val Glu Asp Lys Thr Ile Ser Asp Gln Glu 
    290                 295                 300                 


Ser Phe Arg Glu Val Ile Thr Ala Met Asp Val Met Gln Phe Ser Lys 
305                 310                 315                 320 


Glu Glu Val Trp Glu Val Ser Arg Leu Leu Ala Gly Ile Leu His Leu 
                325                 330                 335     


Gly Asn Ile Glu Phe Ile Thr Ala Gly Gly Ala Gln Val Ser Phe Lys 
            340                 345                 350         


Thr Ala Leu Gly Arg Ser Ala Glu Leu Leu Gly Leu Asp Pro Thr Gln 
        355                 360                 365             


Leu Thr Asp Ala Leu Thr Gln Arg Ser Met Phe Leu Arg Gly Glu Glu 
    370                 375                 380                 


Ile Leu Thr Pro Leu Asn Val Gln Gln Ala Val Asp Ser Arg Asp Ser 
385                 390                 395                 400 


Leu Ala Met Ala Leu Tyr Ala Cys Cys Phe Glu Trp Val Ile Lys Lys 
                405                 410                 415     


Ile Asn Ser Arg Ile Lys Gly Asn Glu Asp Phe Lys Ser Ile Gly Ile 
            420                 425                 430         


Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Val Asn His Phe Glu Gln 
        435                 440                 445             


Phe Asn Ile Asn Tyr Ala Asn Glu Lys Leu Gln Glu Tyr Phe Asn Lys 
    450                 455                 460                 


His Ile Phe Ser Leu Glu Gln Leu Glu Tyr Ser Arg Glu Gly Leu Val 
465                 470                 475                 480 


Trp Glu Asp Ile Asp Trp Ile Asp Asn Gly Glu Cys Leu Asp Leu Ile 
                485                 490                 495     


Glu Lys Lys Leu Gly Leu Leu Ala Leu Ile Asn Glu Glu Ser His Phe 
            500                 505                 510         


Pro Gln Ala Thr Asp Ser Thr Leu Leu Glu Lys Leu His Ser Gln His 
        515                 520                 525             


Ala Asn Asn His Phe Tyr Val Lys Pro Arg Val Ala Val Asn Asn Phe 
    530                 535                 540                 


Gly Val Lys His Tyr Ala Gly Glu Val Gln Tyr Asp Val Arg Gly Ile 
545                 550                 555                 560 


Leu Glu Lys Asn Arg Asp Thr Phe Arg Asp Asp Leu Leu Asn Leu Leu 
                565                 570                 575     


Arg Glu Ser Arg Phe Asp Phe Ile Tyr Asp Leu Phe Glu His Val Ser 
            580                 585                 590         


Ser Arg Asn Asn Gln Asp Thr Leu Lys Cys Gly Ser Lys His Arg Arg 
        595                 600                 605             


Pro Thr Val Ser Ser Gln Phe Lys Asp Ser Leu His Ser Leu Met Ala 
    610                 615                 620                 


Thr Leu Ser Ser Ser Asn Pro Phe Phe Val Arg Cys Ile Lys Pro Asn 
625                 630                 635                 640 


Met Gln Lys Met Pro Asp Gln Phe Asp Gln Ala Val Val Leu Asn Gln 
                645                 650                 655     


Leu Arg Tyr Ser Gly Met Leu Glu Thr Val Arg Ile Arg Lys Ala Gly 
            660                 665                 670         


Tyr Ala Val Arg Arg Pro Phe Gln Asp Phe Tyr Lys Arg Tyr Lys Val 
        675                 680                 685             


Leu Met Arg Asn Leu Ala Leu Pro Glu Asp Val Arg Gly Lys Cys Thr 
    690                 695                 700                 


Ser Leu Leu Gln Leu Tyr Asp Ala Ser Asn Ser Glu Trp Gln Leu Gly 
705                 710                 715                 720 


Lys Thr Lys Val Phe Leu Arg Glu Ser Leu Glu Gln Lys Leu Glu Lys 
                725                 730                 735     


Arg Arg Glu Glu Glu Val Ser His Ala Ala Met Val Ile Arg Ala His 
            740                 745                 750         


Val Leu Gly Phe Leu Ala Arg Lys Gln Tyr Arg Lys Val Leu Tyr Cys 
        755                 760                 765             


Val Val Ile Ile Gln Lys Asn Tyr Arg Ala Phe Leu Leu Arg Arg Arg 
    770                 775                 780                 


Phe Leu His Leu Lys Lys Ala Ala Ile Val Phe Gln Lys Gln Leu Arg 
785                 790                 795                 800 


Gly Gln Ile Ala Arg Arg Val Tyr Arg Gln Leu Leu Ala Glu Lys Arg 
                805                 810                 815     


Glu Gln Glu Glu Lys Lys Lys Gln Glu Glu Glu Glu Lys Lys Lys Arg 
            820                 825                 830         


Glu Glu Glu Glu Arg Glu Arg Glu Arg Glu Arg Arg Glu Ala Glu Leu 
        835                 840                 845             


Arg Ala Gln Gln Glu Glu Glu Thr Arg Lys Gln Gln Glu Leu Glu Ala 
    850                 855                 860                 


Leu Gln Lys Ser Gln Lys Glu Ala Glu Leu Thr Arg Glu Leu Glu Lys 
865                 870                 875                 880 


Gln Lys Glu Asn Lys Gln Val Glu Glu Ile Leu Arg Leu Glu Lys Glu 
                885                 890                 895     


Ile Glu Asp Leu Gln Arg Met Lys Glu Gln Gln Glu Leu Ser Leu Thr 
            900                 905                 910         


Glu Ala Ser Leu Gln Lys Leu Gln Glu Arg Arg Asp Gln Glu Leu Arg 
        915                 920                 925             


Arg Leu Glu Glu Glu Ala Cys Arg Ala Ala Gln Glu Phe Leu Glu Ser 
    930                 935                 940                 


Leu Asn Phe Asp Glu Ile Asp Glu Cys Val Arg Asn Ile Glu Arg Ser 
945                 950                 955                 960 


Leu Ser Val Gly Ser Glu Phe Ser Ser Glu Leu Ala Glu Ser Ala Cys 
                965                 970                 975     


Glu Glu Lys Pro Asn Phe Asn Phe Ser Gln Pro Tyr Pro Glu Glu Glu 
            980                 985                 990         


Val Asp Glu Gly Phe Glu Ala Asp  Asp Asp Ala Phe Lys  Asp Ser Pro 
        995                 1000                 1005             


Asn Pro  Ser Glu His Gly His  Ser Asp Gln Arg Thr  Ser Gly Ile 
    1010                 1015                 1020             


Arg Thr  Ser Asp Asp Ser Ser  Glu Glu Asp Pro Tyr  Met Asn Asp 
    1025                 1030                 1035             


Thr Val  Val Pro Thr Ser Pro  Ser Ala Asp Ser Thr  Val Leu Leu 
    1040                 1045                 1050             


Ala Pro  Ser Val Gln Asp Ser  Gly Ser Leu His Asn  Ser Ser Ser 
    1055                 1060                 1065             


Gly Glu  Ser Thr Tyr Cys Met  Pro Gln Asn Ala Gly  Asp Leu Pro 
    1070                 1075                 1080             


Ser Pro  Asp Gly Asp Tyr Asp  Tyr Asp Gln Asp Asp  Tyr Glu Asp 
    1085                 1090                 1095             


Gly Ala  Ile Thr Ser Gly Ser  Ser Val Thr Phe Ser  Asn Ser Tyr 
    1100                 1105                 1110             


Gly Ser  Gln Trp Ser Pro Asp  Tyr Arg Cys Ser Val  Gly Thr Tyr 
    1115                 1120                 1125             


Asn Ser  Ser Gly Ala Tyr Arg  Phe Ser Ser Glu Gly  Ala Gln Ser 
    1130                 1135                 1140             


Ser Phe  Glu Asp Ser Glu Glu  Asp Phe Asp Ser Arg  Phe Asp Thr 
    1145                 1150                 1155             


Asp Asp  Glu Leu Ser Tyr Arg  Arg Asp Ser Val Tyr  Ser Cys Val 
    1160                 1165                 1170             


Thr Leu  Pro Tyr Phe His Ser  Phe Leu Tyr Met Lys  Gly Gly Leu 
    1175                 1180                 1185             


Met Asn  Ser Trp Lys Arg Arg  Trp Cys Val Leu Lys  Asp Glu Thr 
    1190                 1195                 1200             


Phe Leu  Trp Phe Arg Ser Lys  Gln Glu Ala Leu Lys  Gln Gly Trp 
    1205                 1210                 1215             


Leu His  Lys Lys Gly Gly Gly  Ser Ser Thr Leu Ser  Arg Arg Asn 
    1220                 1225                 1230             


Trp Lys  Lys Arg Trp Phe Val  Leu Arg Gln Ser Lys  Leu Met Tyr 
    1235                 1240                 1245             


Phe Glu  Asn Asp Ser Glu Glu  Lys Leu Lys Gly Thr  Val Glu Val 
    1250                 1255                 1260             


Arg Thr  Ala Lys Glu Ile Ile  Asp Asn Thr Thr Lys  Glu Asn Gly 
    1265                 1270                 1275             


Ile Asp  Ile Ile Met Ala Asp  Arg Thr Phe His Leu  Ile Ala Glu 
    1280                 1285                 1290             


Ser Pro  Glu Asp Ala Ser Gln  Trp Phe Ser Val Leu  Ser Gln Val 
    1295                 1300                 1305             


His Ala  Ser Thr Asp Gln Glu  Ile Gln Glu Met His  Asp Glu Gln 
    1310                 1315                 1320             


Ala Asn  Pro Gln Asn Ala Val  Gly Thr Leu Asp Val  Gly Leu Ile 
    1325                 1330                 1335             


Asp Ser  Val Cys Ala Ser Asp  Ser Pro Asp Arg Pro  Asn Ser Phe 
    1340                 1345                 1350             


Val Ile  Ile Thr Ala Asn Arg  Val Leu His Cys Asn  Ala Asp Thr 
    1355                 1360                 1365             


Pro Glu  Glu Met His His Trp  Ile Thr Leu Leu Gln  Arg Ser Lys 
    1370                 1375                 1380             


Gly Asp  Thr Arg Val Glu Gly  Gln Glu Phe Ile Val  Arg Gly Trp 
    1385                 1390                 1395             


Leu His  Lys Glu Val Lys Asn  Ser Pro Lys Met Ser  Ser Leu Lys 
    1400                 1405                 1410             


Leu Lys  Lys Arg Trp Phe Val  Leu Thr His Asn Ser  Leu Asp Tyr 
    1415                 1420                 1425             


Tyr Lys  Ser Ser Glu Lys Asn  Ala Leu Lys Leu Gly  Thr Leu Val 
    1430                 1435                 1440             


Leu Asn  Ser Leu Cys Ser Val  Val Pro Pro Asp Glu  Lys Ile Phe 
    1445                 1450                 1455             


Lys Glu  Thr Gly Tyr Trp Asn  Val Thr Val Tyr Gly  Arg Lys His 
    1460                 1465                 1470             


Cys Tyr  Arg Leu Tyr Thr Lys  Leu Leu Asn Glu Ala  Thr Arg Trp 
    1475                 1480                 1485             


Ser Ser  Ala Ile Gln Asn Val  Thr Asp Thr Lys Ala  Pro Ile Asp 
    1490                 1495                 1500             


Thr Pro  Thr Gln Gln Leu Ile  Gln Asp Ile Lys Glu  Asn Cys Leu 
    1505                 1510                 1515             


Asn Ser  Asp Val Val Glu Gln  Ile Tyr Lys Arg Asn  Pro Ile Leu 
    1520                 1525                 1530             


Arg Tyr  Thr His His Pro Leu  His Ser Pro Leu Leu  Pro Leu Pro 
    1535                 1540                 1545             


Tyr Gly  Asp Ile Asn Leu Asn  Leu Leu Lys Asp Lys  Gly Tyr Thr 
    1550                 1555                 1560             


Thr Leu  Gln Asp Glu Ala Ile  Lys Ile Phe Asn Ser  Leu Gln Gln 
    1565                 1570                 1575             


Leu Glu  Ser Met Ser Asp Pro  Ile Pro Ile Ile Gln  Gly Ile Leu 
    1580                 1585                 1590             


Gln Thr  Gly His Asp Leu Arg  Pro Leu Arg Asp Glu  Leu Tyr Cys 
    1595                 1600                 1605             


Gln Leu  Ile Lys Gln Thr Asn  Lys Val Pro His Pro  Gly Ser Val 
    1610                 1615                 1620             


Gly Asn  Leu Tyr Ser Trp Gln  Ile Leu Thr Cys Leu  Ser Cys Thr 
    1625                 1630                 1635             


Phe Leu  Pro Ser Arg Gly Ile  Leu Lys Tyr Leu Lys  Phe His Leu 
    1640                 1645                 1650             


Lys Arg  Ile Arg Glu Gln Phe  Pro Gly Thr Glu Met  Glu Lys Tyr 
    1655                 1660                 1665             


Ala Leu  Phe Thr Tyr Glu Ser  Leu Lys Lys Thr Lys  Cys Arg Glu 
    1670                 1675                 1680             


Phe Val  Pro Ser Arg Asp Glu  Ile Glu Ala Leu Ile  His Arg Gln 
    1685                 1690                 1695             


Glu Met  Thr Ser Thr Val Tyr  Cys His Gly Gly Gly  Ser Cys Lys 
    1700                 1705                 1710             


Ile Thr  Ile Asn Ser His Thr  Thr Ala Gly Glu Val  Val Glu Lys 
    1715                 1720                 1725             


Leu Ile  Arg Gly Leu Ala Met  Glu Asp Ser Arg Asn  Met Phe Ala 
    1730                 1735                 1740             


Leu Phe  Glu Tyr Asn Gly His  Val Asp Lys Ala Ile  Glu Ser Arg 
    1745                 1750                 1755             


Thr Val  Val Ala Asp Val Leu  Ala Lys Phe Glu Lys  Leu Ala Ala 
    1760                 1765                 1770             


Thr Ser  Glu Val Gly Asp Leu  Pro Trp Lys Phe Tyr  Phe Lys Leu 
    1775                 1780                 1785             


Tyr Cys  Phe Leu Asp Thr Asp  Asn Val Pro Lys Asp  Ser Val Glu 
    1790                 1795                 1800             


Phe Ala  Phe Met Phe Glu Gln  Ala His Glu Ala Val  Ile His Gly 
    1805                 1810                 1815             


His His  Pro Ala Pro Glu Glu  Asn Leu Gln Val Leu  Ala Ala Leu 
    1820                 1825                 1830             


Arg Leu  Gln Tyr Leu Gln Gly  Asp Tyr Thr Leu His  Ala Ala Ile 
    1835                 1840                 1845             


Pro Pro  Leu Glu Glu Val Tyr  Ser Leu Gln Arg Leu  Lys Ala Arg 
    1850                 1855                 1860             


Ile Ser  Gln Ser Thr Lys Thr  Phe Thr Pro Cys Glu  Arg Leu Glu 
    1865                 1870                 1875             


Lys Arg  Arg Thr Ser Phe Leu  Glu Gly Thr Leu Arg  Arg Ser Phe 
    1880                 1885                 1890             


Arg Thr  Gly Ser Val Val Arg  Gln Lys Val Glu Glu  Glu Gln Met 
    1895                 1900                 1905             


Leu Asp  Met Trp Ile Lys Glu  Glu Val Ser Ser Ala  Arg Ala Ser 
    1910                 1915                 1920             


Ile Ile  Asp Lys Trp Arg Lys  Phe Gln Gly Met Asn  Gln Glu Gln 
    1925                 1930                 1935             


Ala Met  Ala Lys Tyr Met Ala  Leu Ile Lys Glu Trp  Pro Gly Tyr 
    1940                 1945                 1950             


Gly Ser  Thr Leu Phe Asp Val  Glu Cys Lys Glu Gly  Gly Phe Pro 
    1955                 1960                 1965             


Gln Glu  Leu Trp Leu Gly Val  Ser Ala Asp Ala Val  Ser Val Tyr 
    1970                 1975                 1980             


Lys Arg  Gly Glu Gly Arg Pro  Leu Glu Val Phe Gln  Tyr Glu His 
    1985                 1990                 1995             


Ile Leu  Ser Phe Gly Ala Pro  Leu Ala Asn Thr Tyr  Lys Ile Val 
    2000                 2005                 2010             


Val Asp  Glu Arg Glu Leu Leu  Phe Glu Thr Ser Glu  Val Val Asp 
    2015                 2020                 2025             


Val Ala  Lys Leu Met Lys Ala  Tyr Ile Ser Met Ile  Val Lys Lys 
    2030                 2035                 2040             


Arg Tyr  Ser Thr Thr Arg Ser  Ala Ser Ser Gln Gly  Ser Ser Arg 
    2045                 2050                 2055             


<210>  265
<211>  6960
<212>  DNA
<213>  Homo sapiens

<400>  265
atgttaacca tgagcgtgac actttccccc ctgaggtcac aggacctgga tcccatggct       60

actgatgctt cacccatggc catcaacatg acacccactg tggagcaggg tgagggagaa      120

gaggcaatga aggacatgga ctctgaccag cagtatgaaa agccaccccc actacacaca      180

ggggctgact ggaagattgt cctccactta cctgaaattg agacctggct ccggatgacc      240

tcagagaggg tccgagacct aacctattca gtccagcagg attcggacag caagcatgtg      300

gatgtacatc tagttcaact aaaggacatt tgtgaagata tttctgatca tgttgagcaa      360

atccatgccc tccttgaaac agagttctcc ctaaagctgc tgtcttactc tgtcaacgtg      420

atagtggaca tccacgcagt gcagctcctc tggcaccagc ttcgagtctc agtgctggtt      480

ctgcgggagc gcattctgca aggtctgcag gacgccaatg gcaactacac taggcagacg      540

gacattctgc aagctttctc tgaagagaca aaagagggcc ggcttgattc tctaacagaa      600

gtggatgact caggacaatt aaccatcaaa tgttctcaaa attacttgtc tctggattgt      660

ggcattactg cattcgaact gtctgactac agtccaagtg aggatttgct cagtgggcta      720

ggtgacatga cctctagcca agtcaaaacc aaaccctttg actcttggag ctacagtgag      780

atggaaaagg agtttcctga gcttatccga agtgttggtt tacttacggt agctgctgac      840

tctatctcta ccaatggcag tgaagcagtt actgaggagg tatctcaagt atctctctca      900

gtagacgaca aaggtggatg tgaggaagac aatgcttctg cagtcgaaga gcaaccaggc      960

ttaacactgg gggtgtcatc atcttcagga gaagctctga caaatgctgc tcaaccctcc     1020

tctgagactg tgcagcaaga atccagttcc tcctcccatc atgatgcaaa gaatcagcag     1080

cctgttcctt gtgaaaatgc aacccccaaa cgaaccatca gagattgctt taattataac     1140

gaggactctc ccacgcagcc tacattgcca aaaagaggac tttttcttaa agaggaaact     1200

tttaagaatg atctgaaagg caatggtgga aagaggcaaa tggttgatct aaagcctgag     1260

atgagcagaa gcaccccttc gctagtagat cctcctgaca gatccaaact ttgcctggta     1320

ttgcagtctt cttaccccaa cagcccttct gctgccagcc agtcttatga gtgtttacac     1380

aaggtgggga atgggaacct tgaaaacaca gtcaaatttc acattaaaga aatttcttcc     1440

agcctgggaa ggcttaacga ctgctataaa gagaaatctc gacttaaaaa gccacacaag     1500

acctcagaag aggtgcctcc atgccgaaca cctaaacggg ggactggttc aggcaaacaa     1560

gctaaaaata caaagagctc agcagtgcca aatggagagc tttcttatac ttccaaggcc     1620

atagaggggc cacaaacaaa ttctgcttcc acatcctcac ttgagccttg taatcagaga     1680

agttggaatg ccaaattgca attgcagtca gaaacatcca gttcaccagc ttttactcag     1740

agcagtgaat cctctgttgg ctcagacaac atcatgtctc cggtgccact tctttcaaaa     1800

cacaaaagca aaaaaggtca agcctcctct ccaagtcacg tcactaggaa tggtgaggtt     1860

gtggaggcct ggtatggctc tgatgaatac ctagcactgc cctctcacct taagcagaca     1920

gaagtattgg ctttgaagtt ggaaaaccta acaaagcttc tgcctcagaa acccagagga     1980

gaaaccatcc agaatattga tgactgggaa ctgtctgaaa tgaattcaga ttctgaaatc     2040

tatccaacct atcatgtcaa aaagaagcat acaaggctag gcagggtgtc tccaagctca     2100

tctagtgaca tagcctcttc actaggggag agcattgaat ctgggcccct gagtgacatt     2160

ctttctgatg aggagtccag tatgcctctc gctggcatga aaaagtatgc tgatgagaag     2220

tcagaaagag cttcatcctc tgagaaaaat gagagccatt ctgccactaa atcagcttta     2280

attcagaaac tgatgcaaga tattcagcac caagacaact atgaagccat atgggaaaaa     2340

atagaggggt ttgtaaacaa actggatgaa ttcattcaat ggttaaatga agccatggaa     2400

actacagaaa attggactcc ccctaaagca gagatggatg accttaaact gtatctggag     2460

acacacttga gttttaagtt gaatgtagac agtcattgtg ctctcaagga agctgtggag     2520

gaggaaggac accaacttct tgagcttatt gcatctcaca aagcaggact gaaggacatg     2580

ctgcggatga ttgcaagtca atggaaggag ctgcagaggc aaatcaaacg gcagcacagc     2640

tggattctca gggctctgga taccatcaaa gccgagatac tggctactga tgtgtctgtg     2700

gaggatgagg aagggactgg aagccccaag gctgaggttc aactatgcta cctggaagca     2760

caaagagatg ctgttgagca gatgtccctc aagctgtaca gcgagcagta taccagcagc     2820

agcaagcgaa aggaagagtt tgctgatatg tcaaaagttc attcagtggg aagcaatggg     2880

cttctggact ttgattcaga atatcaggag ctctgggatt ggctgattga catggagtcc     2940

cttgtgatgg acagccacga cctgatgatg tcagaggagc agcagcagca tctttacaag     3000

cgatacagtg tggaaatgtc catcagacac ctgaaaaaga cggagctgct tagtaaggtt     3060

gaagctttga agaaaggtgg cgttttacta ccaaatgatc tccttgaaaa agtggattca     3120

attaatgaaa aatgggaact gcttgggaaa accctaggag agaagatcca ggacacaatg     3180

gcagggcaca gtgggtcgag tccacgtgac ctgctctctc ctgaaagtgg aagcctggta     3240

aggcagctgg aggtcaggat caaagaactg aaaggatggc taagagatac agagcttttc     3300

atcttcaatt cctgtctgag acaagaaaag gaaggaacaa tgaatactga gaaacaactg     3360

caatacttta agtccctctg tcgtgaaatc aagcaacgac gtcgaggagt tgcctccatt     3420

ctgcgactat gccagcatct tttggatgac cgggagactt gcaatctgaa tgcagaccac     3480

cagcccatgc agctgatcat tgtaaatctt gaaagaaggt gggaagccat tgtcatgcaa     3540

gccgtccagt ggcaaacacg tctacaaaag aagatgggaa aggaatctga gactttgaat     3600

gtgattgatc ctggcttgat ggacctaaat gggatgagtg aggatgccct ggaatgggat     3660

gaaatggaca taagtaacaa gttaattagt ttgaatgagg aatcaaatga ccttgatcaa     3720

gaactccaac ctgttatccc ttccttgaag cttggagaga caagtaatga ggaccctggt     3780

tatgacgagg aggctgataa ccatggggga tctcagtatg cctcaaatat tactgccccc     3840

tctagtccac acatttacca ggtgtacagc ctccacaatg ttgaactcta tgaggacaac     3900

cacatgccat ttctgaaaaa caatccaaag gtcactggca tgacacagcc taatgtttta     3960

actaagagtc tcagtaaaga ctcttcattt tcatctacca aatctttgcc agatcttcta     4020

ggtggttcca atttggtaaa gccctgcgca tgtcatggag gagacatgag ccagaattca     4080

ggcagtgaga gtggaattgt cagtgaagga gacacagaaa ccactaccaa ctctgaaatg     4140

tgcttgctca atgcagtgga tgggtcccca agtaaccttg aaactgaaca tctggaccca     4200

caaatgggag atgcagttaa cgtgttaaag caaaaattta cagatgaggg ggaaagcatt     4260

aagcttccaa atagctctca gtcgtccatt tcaccagtgg gttgtgtaaa tggaaaagtt     4320

ggagatttaa acagtattac caaacatacc cctgactgtt tgggagaaga attacaagga     4380

aaacatgatg tgtttacatt ttatgattac tcatacctcc aaggctcaaa actcaaatta     4440

ccaatgataa tgaaacagtc acaaagcgaa aaagcgcatg tggaggatcc cctgcttcgt     4500

ggtttttatt ttgataaaaa atcatgcaaa tctaaacatc agactacaga gttacaacca     4560

gatgtacctc cccatgaaag gattttggca agtgcatctc atgaaatgga tcgcatttca     4620

tataaaagtg gcaatataga aaagacattc actggcatgc agaatgccaa acagctctcc     4680

cttttatctc atagttcatc tattgagtcc ctttctccag ggggtgattt atttggattg     4740

ggcatcttta aaaatggcag tgacagcctc cagcgaagca cttctttaga aagttggttg     4800

acttcctata aaagcaatga agatctcttt agctgtcaca gctctgggga tataagcgtg     4860

agcagtggct cagttggtga actaagtaaa agaacattag atctcctgaa tcgtttggag     4920

aatatccaga gcccctcaga gcaaaagata aaacgaagtg tttctgatat cactcttcaa     4980

agcagttccc aaaagatgtc ctttactggc cagatgtcat tggacatagc atcttctatc     5040

aatgaagact cagcggcatc tctaacagaa cttagcagca gtgacgagct ctctctttgc     5100

tcagaggata ttgtgttaca caagaacaag atcccggaat cgaatgcatc gttcaggaag     5160

cgtctgactc gttcagtggc tgatgaaagc gatgtcaatg tcagcatgat tgttaatgtc     5220

tcttgcacct ctgcttgcac tgatgatgaa gatgacagcg acctgctctc cagctctacc     5280

cttaccttga ctgaagaaga gctgtgcatc aaagatgagg atgacgactc cagtattgca     5340

acagatgatg aaatttatga agactgcacc ttgatgtcag ggctagacta cataaagaat     5400

gaattacaga cctggattag gccaaaattg tctttgacaa gagataagaa aaggtgcaat     5460

gtcagtgatg agatgaaggg cagtaaagat ataagtagca gtgagatgac caatccctct     5520

gatactctga atattgagac ccttctaaat ggctctgtaa aacgtgtctc tgaaaataat     5580

ggaaatggta agaattcatc tcatacccat gagttaggga caaagcgtga aaataagaaa     5640

actattttca aagttaataa agatccatat gtggctgaca tggaaaatgg caatattgaa     5700

ggtattccag aaaggcaaaa gggaaaaccg aatgtgactt caaaggtatc agaaaatctt     5760

ggttcacatg ggaaagagat ttcagagagt gagcattgta agtgtaaagc acttatggat     5820

agtttagatg attcaaatac tgctggcaag gaatttgttt cccaagatgt tagacatctt     5880

ccaaagaaat gtccaaatca ccaccatttt gaaaatcaaa gcactgcctc tactcccact     5940

gagaagtctt tctcagaact ggctttagaa accaggttta acaacagaca agactctgat     6000

gcactgaaat catctgatga tgcaccgagt atggctggaa aatctgctgg ttgttgccta     6060

gcacttgaac aaaacggaac agaggaaaat gcttctatca gcaacatttc ctgttgcaac     6120

tgtgagccag atgttttcca tcaaaaagat gccgaagatt gttcagtaca caactttgtt     6180

aaggaaatca ttgacatggc ttcgacagcc ctaaaaagta aatctcaacc tgaaaacgag     6240

gtggctgctc ctacttcatt aactcaaatc aaggagaaag tgttggagca ttctcaccgg     6300

cccatccagc tgagaaaagg ggacttttat tcgtacttat ctctctcatc tcatgacagt     6360

gattgtgggg aggtcaccaa ttacatagaa gagaaaagca gcactccatt gccactagac     6420

accactgact cgggcttaga tgacaaggaa gatattgaat gcttttttga ggcctgtgtt     6480

gagggtgact ctgatggaga ggagccttgt ttctctagtg ctcctccaaa tgaatctgca     6540

gttcccagcg aagctgcaat gccactacaa gcaacagcat gttcttctga gttcagtgat     6600

agttctcttt cagctgatga tgcagataca gtggctcttt caagtccttc ctctcaggaa     6660

agagctgagg ttggaaagga agtgaatggt ttgccccaaa cttccagtgg ctgtgcagaa     6720

aacttagagt ttactccttc aaagcttgac agtgaaaagg aaagttccgg aaaaccaggt     6780

gaatctggaa tgccagaaga acataatgct gcttcagcca aatctaaagt tcaagacctc     6840

tccttgaagg caaatcagcc aacagacaag gccgcattgc atcccagccc caaaacttta     6900

acctgtgaag aaaatcttct aaaccttcat gaaaaacgac atagaaatat gcataggtag     6960


<210>  266
<211>  2319
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr 
        355                 360                 365             


Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys 
            500                 505                 510         


Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Thr Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Thr Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Thr Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Thr Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Thr 
    1100                 1105                 1110             


Met Asn  Thr Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Thr Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Thr Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Thr Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Thr Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Thr 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Thr Gly Met Thr  Gln Pro Asn Val Leu  Thr Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Thr Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Thr Glu Thr Thr  Thr Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Thr  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Thr Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Thr Lys His Thr  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Thr Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Ala His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Thr  Thr Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Thr Phe  Thr Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Thr Ser  Leu Glu Ser Trp Leu  Thr Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Thr Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Thr Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Thr Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Thr Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Thr Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Thr 
    1730                 1735                 1740             


Ser Ala  Cys Thr Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Thr  Leu Thr Leu Thr Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Thr Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Thr  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Thr Trp  Ile Arg Pro Lys Leu  Ser Leu Thr Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Thr Asn Pro Ser  Asp Thr Leu Asn Ile  Glu Thr Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Thr His  Glu Leu Gly Thr Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Thr Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Thr Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Thr Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Thr  Ala Ser Thr Pro Thr  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Thr Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Thr Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Thr Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Thr  Ser Leu Thr 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Thr Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Thr  Pro Leu Pro Leu Asp  Thr Thr Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Thr Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Thr  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Thr Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Thr  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Thr Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Thr Leu  Thr Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210>  267
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  267
atgtctgttc gatacagctc aagcaagcac tactcttcct cccgcagtgg aggaggagga       60

ggaggaggag gatgtggagg aggaggagga gtgtcatccc taagaatttc tagcagcaaa      120

ggctcccttg gtggaggatt tagctcaggg gggttcagtg gtggctcttt tagccgtggg      180

agctctggtg ggggctgctt tgggggctca tcaggtggct atggaggatt aggaggtttt      240

ggtggaggta gctttcgtgg aagctatgga agtagcagct ttggtgggag ttatggaggc      300

agctttggag ggggcagttt cggaggtggc agctttggtg ggggcagctt tggtggaggc      360

ggctttggtg gaggcggctt tggaggaggc tttggtggtg gatttggagg agatggtggc      420

cttctctctg gaaatgaaaa agtaaccatg cagaatctga atgaccgcct ggcttcctac      480

ttggacaaag ttcgggctct ggaagaatca aactatgagc tggaaggcaa aatcaaggag      540

tggtatgaaa agcatggcaa ctcacatcag ggggagcctc gtgactacag caaatactac      600

aaaaccatcg atgaccttaa aaatcagatt ctcaacctaa caactgataa tgccaacatc      660

ctgcttcaga tcgacaatgc caggctggca gctgatgact tcaggctgaa gtatgagaat      720

gaggtagctc tgcgccagag cgtggaggct gacatcaacg gcctgcgtag ggtgctggat      780

gagctgaccc tgaccaaggc tgacctggag atgcaaattg agagcctgac tgaagagctg      840

gcctatctga agaagaacca cgaggaggaa atgaaagacc ttcgaaatgt gtccactggt      900

gatgtgaatg tggaaatgaa tgctgccccg ggtgttgatc tgactcaact tctgaataac      960

atgagaagcc aatatgaaca acttgctgaa caaaaccgca aagatgctga agcctggttc     1020

aatgaaaaga gcaaggaact gactacagaa attgataata acattgaaca gatatccagc     1080

tataaatctg agattactga attgagacgt aatgtacaag ctctggagat agaactacag     1140

tcccaactgg ccttgaaaca atccctggaa gcctccttgg cagaaacaga aggtcgctac     1200

tgtgtgcagc tctcacagat tcaggcccag atatccgctc tggaagaaca gttgcaacag     1260

attcgagctg aaaccgagtg ccagaatact gaataccaac aactcctgga tattaagatc     1320

cgactggaga atgaaattca aacctaccgc agcctgctag aaggagaggg aagttccgga     1380

ggcggcggac gcggcggcgg aagtttcggc ggcggctacg gcggcggaag ctccggcggc     1440

ggaagctccg gcggcggcca cggcggcggc cacggcggca gttccggcgg cggctacgga     1500

ggcggaagct ccggcggcgg aagctccggc ggcggctacg ggggcggaag ctccagcggc     1560

ggccacggcg gcagttccag cggcggctac ggtggtggca gttccggcgg cggcggcggc     1620

ggctacgggg gcggcagctc cggcggcggc agcagctccg gcggcggata cggcggcggc     1680

agctccagcg gaggccacaa gtcctcctct tccgggtccg tgggcgagtc ttcatctaag     1740

ggaccaagat actaa                                                      1755


<210>  268
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  269
<211>  2649
<212>  DNA
<213>  Homo sapiens

<400>  269
atgggccctt ggagccgcag cctctcggcg ctgctgctgc tgctgcaggt ctcctcttgg       60

ctctgccagg agccggagcc ctgccaccct ggctttgacg ccgagagcta cacgttcacg      120

gtgccccggc gccacctgga gagaggccgc gtcctgggca gagtgaattt tgaagattgc      180

accggtcgac aaaggacagc ctatttttcc ctcgacaccc gattcaaagt gggcacagat      240

ggtgtgatta cagtcaaaag gcctctacgg tttcataacc cacagatcca tttcttggtc      300

tacgcctggg actccaccta cagaaagttt tccaccaaag tcacgctgaa tacagtgggg      360

caccaccacc gccccccgcc ccatcaggcc tccgtttctg gaatccaagc agaattgctc      420

acatttccca actcctctcc tggcctcaga agacagaaga gagactgggt tattcctccc      480

atcagctgcc cagaaaatga aaaaggccca tttcctaaaa acctggttca gatcaaatcc      540

aacaaagaca aagaaggcaa ggttttctac agcatcactg gccaaggagc tgacacaccc      600

cctgttggtg tctttattat tgaaagagaa acaggatggc tgaaggtgac agagcctctg      660

gatagagaac gcattgccac atacactctc ttctctcacg ctgtgtcatc caacgggaat      720

gcagttgagg atccaatgga gattttgatc acggtaaccg atcagaatga caacaagccc      780

gaattcaccc aggaggtctt taaggggtct gtcatggaag gtgctcttcc aggaacctct      840

gtgatggagg tcacagccac agacgcggac gatgatgtga acacctacaa tgccgccatc      900

gcttacacca tcctcagcca agatcctgag ctccctgaca aaaatatgtt caccattaac      960

aggaacacag gagtcatcag tgtggtcacc actgggctgg accgagagag tttccctacg     1020

tataccctgg tggttcaagc tgctgacctt caaggtgagg ggttaagcac aacagcaaca     1080

gctgtgatca cagtcactga caccaacgat aatcctccga tcttcaatcc caccacgtac     1140

aagggtcagg tgcctgagaa cgaggctaac gtcgtaatca ccacactgaa agtgactgat     1200

gctgatgccc ccaatacccc agcgtgggag gctgtataca ccatattgaa tgatgatggt     1260

ggacaatttg tcgtcaccac aaatccagtg aacaacgatg gcattttgaa aacagcaaag     1320

ggcttggatt ttgaggccaa gcagcagtac attctacacg tagcagtgac gaatgtggta     1380

ccttttgagg tctctctcac cacctccaca gccaccgtca ccgtggatgt gctggatgtg     1440

aatgaagccc ccatctttgt gcctcctgaa aagagagtgg aagtgtccga ggactttggc     1500

gtgggccagg aaatcacatc ctacactgcc caggagccag acacatttat ggaacagaaa     1560

ataacatatc ggatttggag agacactgcc aactggctgg agattaatcc ggacactggt     1620

gccatttcca ctcgggctga gctggacagg gaggattttg agcacgtgaa gaacagcacg     1680

tacacagccc taatcatagc tacagacaat ggttctccag ttgctactgg aacagggaca     1740

cttctgctga tcctgtctga tgtgaatgac aacgccccca taccagaacc tcgaactata     1800

ttcttctgtg agaggaatcc aaagcctcag gtcataaaca tcattgatgc agaccttcct     1860

cccaatacat ctcccttcac agcagaacta acacacgggg cgagtgccaa ctggaccatt     1920

cagtacaacg acccaaccca agaatctatc attttgaagc caaagatggc cttagaggtg     1980

ggtgactaca aaatcaatct caagctcatg gataaccaga ataaagacca agtgaccacc     2040

ttagaggtca gcgtgtgtga ctgtgaaggg gccgctggcg tctgtaggaa ggcacagcct     2100

gtcgaagcag gattgcaaat tcctgccatt ctggggattc ttggaggaat tcttgctttg     2160

ctaattctga ttctgctgct cttgctgttt cttcggagga gagcggtggt caaagagccc     2220

ttactgcccc cagaggatga cacccgggac aacgtttatt actatgatga agaaggaggc     2280

ggagaagagg accaggactt tgacttgagc cagctgcaca ggggcctgga cgctcggcct     2340

gaagtgactc gtaacgacgt tgcaccaacc ctcatgagtg tcccccggta tcttccccgc     2400

cctgccaatc ccgatgaaat tggaaatttt attgatgaaa atctgaaagc ggctgatact     2460

gaccccacag ccccgcctta tgattctctg ctcgtgtttg actatgaagg aagcggttcc     2520

gaagctgcta gtctgagctc cctgaactcc tcagagtcag acaaagacca ggactatgac     2580

tacttgaacg aatggggcaa tcgcttcaag aagctggctg acatgtacgg aggcggcgag     2640

gacgactag                                                             2649


<210>  270
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  271
<211>  1860
<212>  DNA
<213>  Homo sapiens

<400>  271
atggctgctg ttgtccaaca gaacgaccta gtatttgaat ttgctagtaa cgtcatggag       60

gatgaacgac agcttggtga tccagctatt tttcctgccg taattgtgga acatgttcct      120

ggtgctgata ttctcaatag ttatgccggt ctagcctgtg tggaagagcc caatgacatg      180

attactgaga gttcactgga tgttgctgaa gaagaaatca tagacgatga tgatgatgac      240

atcaccctta cagttgaagc ttcttgtcat gacggggatg aaacaattga aactattgag      300

gctgctgagg cactcctcaa tatggattcc cctggcccta tgctggatga aaaacgaata      360

aataataata tatttagttc acctgaagat gacatggttg ttgccccagt cacccatgtg      420

tccgtcacat tagatgggat tcctgaagtg atggaaacac agcaggtgca agaaaaatat      480

gcagactcac cgggagcctc atcaccagaa cagcctaaga ggaaaaaagg aagaaaaact      540

aaaccaccac gaccagattc cccagccact acgccaaata tatctgtgaa gaagaaaaac      600

aaagatggaa agggaaacac aatttatctt tgggagtttt tactggcact gctccaggac      660

aaggctactt gtcctaaata catcaagtgg acccagcgag agaaaggcat ttttaaattg      720

gtggattcta aagcagtgtc caggttgtgg gggaagcaca aaaacaaacc tgatatgaat      780

tatgagacca tgggaagagc actcaggtac tattaccaaa ggggtattct ggcaaaagtg      840

gaaggtcagc gcttggtgta tcagtttaaa gaaatgccaa aagatcttat atatataaat      900

gatgaggatc caagttccag catagagtct tcagatccat cgctatcttc atcagccact      960

tcaaatagga atcaaaccag ccggtcgaga gtatcttcaa gtccaggggt aaaaggagga     1020

gccactacag ttctaaaacc agggaattct aaagctgcaa aacccaaaga tcctgtggaa     1080

gttgcacaac catcagaagt tttgaggaca gtgcagccca cgcagtctcc atatcctacc     1140

cagctcttcc ggactgttca tgtagtacag ccagtacagg ctgtcccaga gggagaagca     1200

gctagaacca gtaccatgca ggatgaaaca ttaaattctt ccgttcagag tattaggact     1260

atacaggctc caacccaagt tccagtggtt gtgtctccta ggaatcagca gttgcataca     1320

gtaacactcc aaacagtgcc actcacaaca gttatagcca gcacagatcc atcagcaggt     1380

actggatctc agaagtttat tttacaagcc attccatcat cacagcccat gacagtactg     1440

aaagaaaatg tcatgctgca gtcacaaaag gcgggctctc ctccttcaat tgtcttgggc     1500

cctgcccagg ttcagcaggt ccttactagc aatgttcaga ccatttgcaa tggaaccgtc     1560

agtgtggctt cctctccatc cttcagtgct actgcacctg tggtgacctt ttctcctcgc     1620

agttcacagc tggttgctca cccacctggc actgtaatca cttcagttat caaaactcaa     1680

gaaacaaaaa ctcttacaca ggaagtagag aaaaaggaat ctgaagatca tttgaaagag     1740

aacactgaga aaacggagca gcagccacag ccttatgtga tggtagtgtc cagttccaat     1800

ggatttactt ctcaggtagc tatgaaacaa aacgaactgc tggaacccaa ctctttttag     1860


<210>  272
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 
1               5                   10                  15      


Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 
            20                  25                  30          


Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 
        35                  40                  45              


Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 
    50                  55                  60                  


Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 
                85                  90                  95      


Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 
            100                 105                 110         


Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile Phe Ser Ser Pro 
        115                 120                 125             


Glu Asp Asp Met Val Val Ala Pro Val Thr His Val Ser Val Thr Leu 
    130                 135                 140                 


Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val Gln Glu Lys Tyr 
145                 150                 155                 160 


Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro Lys Arg Lys Lys 
                165                 170                 175     


Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro Ala Thr Thr Pro 
            180                 185                 190         


Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys Gly Asn Thr Ile 
        195                 200                 205             


Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Lys Ala Thr Cys 
    210                 215                 220                 


Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys Leu 
225                 230                 235                 240 


Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys His Lys Asn Lys 
                245                 250                 255     


Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr Tyr 
            260                 265                 270         


Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr Gln 
        275                 280                 285             


Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn Asp Glu Asp Pro 
    290                 295                 300                 


Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser Ser Ser Ala Thr 
305                 310                 315                 320 


Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser Ser Ser Pro Gly 
                325                 330                 335     


Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly Asn Ser Lys Ala 
            340                 345                 350         


Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro Ser Glu Val Leu 
        355                 360                 365             


Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr Gln Leu Phe Arg 
    370                 375                 380                 


Thr Val His Val Val Gln Pro Val Gln Ala Val Pro Glu Gly Glu Ala 
385                 390                 395                 400 


Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn Ser Ser Val Gln 
                405                 410                 415     


Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro Val Val Val Ser 
            420                 425                 430         


Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln Thr Val Pro Leu 
        435                 440                 445             


Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly Thr Gly Ser Gln 
    450                 455                 460                 


Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro Met Thr Val Leu 
465                 470                 475                 480 


Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly Ser Pro Pro Ser 
                485                 490                 495     


Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu Thr Ser Asn Val 
            500                 505                 510         


Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser Ser Pro Ser Phe 
        515                 520                 525             


Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg Ser Ser Gln Leu 
    530                 535                 540                 


Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val Ile Lys Thr Gln 
545                 550                 555                 560 


Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys Glu Ser Glu Asp 
                565                 570                 575     


His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln Pro Gln Pro Tyr 
            580                 585                 590         


Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser Gln Val Ala Met 
        595                 600                 605             


Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe 
    610                 615                 


<210>  273
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  273
atggctccct ttggaagaaa cttgctaaag actcggcata aaaacagatc tccaactaaa       60

gacatggatt cagaagagaa ggaaattgtg gtttgggttt gccaagaaga gaagcttgtc      120

tgtgggctga ctaaacgcac cacctctgct gatgtcatcc aggctttgct tgaggaacat      180

gaggctacgt ttggagagaa acgatttctt ctggggaagc ccagtgatta ctgcatcata      240

gagaagtgga gaggctccga aagggttctt cctccactaa ctagaatcct gaagctttgg      300

aaagcgtggg gagatgagca gcccaatatg caatttgttt tggttaaagc agatgctttt      360

cttccagttc ctttgtggcg gacagctgaa gccaaattag tgcaaaacac agaaaaattg      420

tgggagctca gcccagcaaa ctacatgaag actttaccac cagataaaca aaaaagaata      480

gtcaggaaaa ctttccggaa actggctaaa attaagcagg acacagtttc tcatgatcga      540

gataatatgg agacattagt tcatctgatc atttcccagg accatactat tcatcagcaa      600

gtcaagagaa tgaaagagct ggatctggaa attgaaaagt gtgaagctaa gttccatctt      660

gatcgagtag aaaatgatgg agaaaactat gttcaggatg catatttaat gcccagtttc      720

agtgaagttg agcaaaatct agacttgcag tatgaggaaa accagactct ggaggacctg      780

agcgaaagtg atggaattga acagctggaa gaacgactga aatattaccg aatactcatt      840

gataagctct ctgctgaaat agaaaaagag gtaaaaagtg tttgcattga tataaatgaa      900

gatgcggaag gggaagctgc aagtgaactg gaaagctcta atttagagag tgttaagtgt      960

gatttggaga aaagcatgaa agctggtttg aaaattcact ctcatttgag tggcatccag     1020

aaagagatta aatacagtga ctcattgctt cagatgaaag caaaagaata tgaactcctg     1080

gccaaggaat tcaattcact tcacattagc aacaaagatg ggtgccagtt aaaggaaaac     1140

agagcgaagg aatctgaggt tcccagtagc aatggggaga ttcctccctt tactcaaaga     1200

gtatttagca attacacaaa tgacacagac tcggacactg gtatcagttc taaccacagt     1260

caggactccg aaacaacagt aggagatgtg gtgctgttgt caacatag                  1308


<210>  274
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Ala Pro Phe Gly Arg Asn Leu Leu Lys Thr Arg His Lys Asn Arg 
1               5                   10                  15      


Ser Pro Thr Lys Asp Met Asp Ser Glu Glu Lys Glu Ile Val Val Trp 
            20                  25                  30          


Val Cys Gln Glu Glu Lys Leu Val Cys Gly Leu Thr Lys Arg Thr Thr 
        35                  40                  45              


Ser Ala Asp Val Ile Gln Ala Leu Leu Glu Glu His Glu Ala Thr Phe 
    50                  55                  60                  


Gly Glu Lys Arg Phe Leu Leu Gly Lys Pro Ser Asp Tyr Cys Ile Ile 
65                  70                  75                  80  


Glu Lys Trp Arg Gly Ser Glu Arg Val Leu Pro Pro Leu Thr Arg Ile 
                85                  90                  95      


Leu Lys Leu Trp Lys Ala Trp Gly Asp Glu Gln Pro Asn Met Gln Phe 
            100                 105                 110         


Val Leu Val Lys Ala Asp Ala Phe Leu Pro Val Pro Leu Trp Arg Thr 
        115                 120                 125             


Ala Glu Ala Lys Leu Val Gln Asn Thr Glu Lys Leu Trp Glu Leu Ser 
    130                 135                 140                 


Pro Ala Asn Tyr Met Lys Thr Leu Pro Pro Asp Lys Gln Lys Arg Ile 
145                 150                 155                 160 


Val Arg Lys Thr Phe Arg Lys Leu Ala Lys Ile Lys Gln Asp Thr Val 
                165                 170                 175     


Ser His Asp Arg Asp Asn Met Glu Thr Leu Val His Leu Ile Ile Ser 
            180                 185                 190         


Gln Asp His Thr Ile His Gln Gln Val Lys Arg Met Lys Glu Leu Asp 
        195                 200                 205             


Leu Glu Ile Glu Lys Cys Glu Ala Lys Phe His Leu Asp Arg Val Glu 
    210                 215                 220                 


Asn Asp Gly Glu Asn Tyr Val Gln Asp Ala Tyr Leu Met Pro Ser Phe 
225                 230                 235                 240 


Ser Glu Val Glu Gln Asn Leu Asp Leu Gln Tyr Glu Glu Asn Gln Thr 
                245                 250                 255     


Leu Glu Asp Leu Ser Glu Ser Asp Gly Ile Glu Gln Leu Glu Glu Arg 
            260                 265                 270         


Leu Lys Tyr Tyr Arg Ile Leu Ile Asp Lys Leu Ser Ala Glu Ile Glu 
        275                 280                 285             


Lys Glu Val Lys Ser Val Cys Ile Asp Ile Asn Glu Asp Ala Glu Gly 
    290                 295                 300                 


Glu Ala Ala Ser Glu Leu Glu Ser Ser Asn Leu Glu Ser Val Lys Cys 
305                 310                 315                 320 


Asp Leu Glu Lys Ser Met Lys Ala Gly Leu Lys Ile His Ser His Leu 
                325                 330                 335     


Ser Gly Ile Gln Lys Glu Ile Lys Tyr Ser Asp Ser Leu Leu Gln Met 
            340                 345                 350         


Lys Ala Lys Glu Tyr Glu Leu Leu Ala Lys Glu Phe Asn Ser Leu His 
        355                 360                 365             


Ile Ser Asn Lys Asp Gly Cys Gln Leu Lys Glu Asn Arg Ala Lys Glu 
    370                 375                 380                 


Ser Glu Val Pro Ser Ser Asn Gly Glu Ile Pro Pro Phe Thr Gln Arg 
385                 390                 395                 400 


Val Phe Ser Asn Tyr Thr Asn Asp Thr Asp Ser Asp Thr Gly Ile Ser 
                405                 410                 415     


Ser Asn His Ser Gln Asp Ser Glu Thr Thr Val Gly Asp Val Val Leu 
            420                 425                 430         


Leu Ser Thr 
        435 


<210>  275
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  275
atgaccacaa caaggtaccg gcccacctgg gacctggccc tcgacccgct ggtgtcttgc       60

aagctctgtc ttggggagta cccagtggag cagatgacaa ccatagccca gtgccaatgc      120

atcttctgta ctctgtgcct gaaacagtat gttgagctct tgatcaaaga aggattagaa      180

actgcaatta gctgcccaga tgctgcctgc cctaaacagg gccacctaca ggagaacgag      240

attgagtgca tggttgcagc tgaaattatg caaagatata aaaagctaca atttgaaaga      300

gaggtgctgt ttgatccctg tcggacttgg tgcccggcgt ccacctgcca agctgtgtgt      360

cagctccagg acgtggggct gcagaccccc cagccagtgc agtgcaaagc ctgccgtatg      420

gaattctgct ccacctgcaa agccagctgg caccctggcc agggctgccc ggagaccatg      480

ccgatcacct tcctccccgg ggagaccagt gctgctttca aaatggaaga agatgacgcg      540

cccatcaagc gctgccccaa gtgcaaagtc tacatcgagc gagacgaagg ctgcgcgcag      600

atgatgtgca agaactgcaa gcacgccttc tgctggtact gcctggagtc tctggacgat      660

gatttccttc tgatacacta cgataaggga ccctgccgga acaagctggg ccactcccgg      720

gcatctgtga tctggcatcg gacacaggtt gtgggcattt ttgcaggatt tgggctgctg      780

ctcttggtgg cctcaccttt cctactcctg gccactccct ttgtactttg ctgcaagtgc      840

aagtgcagta aaggtgacga cgacccgtta cccacctag                             879


<210>  276
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  277
<211>  1176
<212>  DNA
<213>  Homo sapiens

<400>  277
atgcccggcc cccagggggg cagaggcgcc gccaccatga gcctgggcaa gctctcgcct       60

gtgggctggg tgtccagttc acagggaaag aggcggctga ctgcagacat gatcagccac      120

ccactcgggg acttccgcca caccatgcat gtgggccgtg gcggggatgt cttcggggac      180

acgtccttcc tcagcaacca cggtggcagc tccgggagca cccatcgctc accccgcagc      240

ttcctggcca agaagctgca gctggtgcgg agggtggggg cgcccccccg gaggatggca      300

tctccccctg caccctcccc ggctccaccg gccatctccc ccatcatcaa gaacgccatc      360

tccctgcccc agctcaacca ggccgcctac gacagcctcg tggttggcaa gctcagcttc      420

gacagcagcc ccaccagctc cacggacggc cactccagct acggcctgga ctctgggttc      480

tgcaccatct cccgcctgcc ccgctcggaa aagccgcatg accgagaccg ggatggttcc      540

ttcccctctg agcccgggct tcgccgctct gactctctct tgtccttccg cctggacctc      600

gaccttgggc cctcactcct cagcgagctg ctaggggtca tgagcctccc agaagcccct      660

gcagctgaga ctccagcccc cgctgcaaac cccccagccc ctactgcaaa ccccacgggt      720

cctgctgcaa accccccagc cactactgca aaccccccag cgcctgctgc aaacccctca      780

gcacctgccg caacccccac gggtcctgct gcaaatcccc cagcccctgc cgcaagctcc      840

acaccccatg gacactgtcc caatggggta acagctgggt tgggcccagt ggctgaggtg      900

aagtccagcc cagtgggagg gggtccccga ggacctgctg gccctgccct cggcaggcac      960

tggggagcag gctgggatgg cggccaccac tacccagaga tggatgcgcg gcaggagcgg     1020

gtggaggtgc tgccccaagc ccgggcctcc tgggagagcc tggacgaaga gtggagggcg     1080

ccccaggcag gcagcaggac cccagtgccc agcacagtgc aagcaaacac ctttgaattt     1140

gcggatgctg aggaggatga tgaggtcaag gtgtga                               1176


<210>  278
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Thr Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Thr Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Thr 
        35                  40                  45              


Met His Val Gly Arg Gly Gly Asp Val Phe Gly Asp Thr Ser Phe Leu 
    50                  55                  60                  


Ser Asn His Gly Gly Ser Ser Gly Ser Thr His Arg Ser Pro Arg Ser 
65                  70                  75                  80  


Phe Leu Ala Lys Lys Leu Gln Leu Val Arg Arg Val Gly Ala Pro Pro 
                85                  90                  95      


Arg Arg Met Ala Ser Pro Pro Ala Pro Ser Pro Ala Pro Pro Ala Ile 
            100                 105                 110         


Ser Pro Ile Ile Lys Asn Ala Ile Ser Leu Pro Gln Leu Asn Gln Ala 
        115                 120                 125             


Ala Tyr Asp Ser Leu Val Val Gly Lys Leu Ser Phe Asp Ser Ser Pro 
    130                 135                 140                 


Thr Ser Ser Thr Asp Gly His Ser Ser Tyr Gly Leu Asp Ser Gly Phe 
145                 150                 155                 160 


Cys Thr Ile Ser Arg Leu Pro Arg Ser Glu Lys Pro His Asp Arg Asp 
                165                 170                 175     


Arg Asp Gly Ser Phe Pro Ser Glu Pro Gly Leu Arg Arg Ser Asp Ser 
            180                 185                 190         


Leu Leu Ser Phe Arg Leu Asp Leu Asp Leu Gly Pro Ser Leu Leu Ser 
        195                 200                 205             


Glu Leu Leu Gly Val Met Ser Leu Pro Glu Ala Pro Ala Ala Glu Thr 
    210                 215                 220                 


Pro Ala Pro Ala Ala Asn Pro Pro Ala Pro Thr Ala Asn Pro Thr Gly 
225                 230                 235                 240 


Pro Ala Ala Asn Pro Pro Ala Thr Thr Ala Asn Pro Pro Ala Pro Ala 
                245                 250                 255     


Ala Asn Pro Ser Ala Pro Ala Ala Thr Pro Thr Gly Pro Ala Ala Asn 
            260                 265                 270         


Pro Pro Ala Pro Ala Ala Ser Ser Thr Pro His Gly His Cys Pro Asn 
        275                 280                 285             


Gly Val Thr Ala Gly Leu Gly Pro Val Ala Glu Val Lys Ser Ser Pro 
    290                 295                 300                 


Val Gly Gly Gly Pro Arg Gly Pro Ala Gly Pro Ala Leu Gly Arg His 
305                 310                 315                 320 


Trp Gly Ala Gly Trp Asp Gly Gly His His Tyr Pro Glu Met Asp Ala 
                325                 330                 335     


Arg Gln Glu Arg Val Glu Val Leu Pro Gln Ala Arg Ala Ser Trp Glu 
            340                 345                 350         


Ser Leu Asp Glu Glu Trp Arg Ala Pro Gln Ala Gly Ser Arg Thr Pro 
        355                 360                 365             


Val Pro Ser Thr Val Gln Ala Asn Thr Phe Glu Phe Ala Asp Ala Glu 
    370                 375                 380                 


Glu Asp Asp Glu Val Lys Val 
385                 390     


<210>  279
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  279
atggtgcatc tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac       60

gtggatgaag ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag      120

aggttctttg agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag      180

gtgaaggctc atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac      240

aacctcaagg gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat      300

cctgagaact tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc      360

aaagaattca ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat      420

gccctggccc acaagtatca ctaa                                             444


<210>  280
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  281
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  281
atgggtcgaa aggaagaaga tgactgcagt tcctggaaga aacagaccac caacatccgg       60

aaaaccttca tttttatgga agtgctggga tcaggagctt tctcagaagt tttcctggtg      120

aagcaaagac tgactgggaa gctctttgct ctgaagtgca tcaagaagtc acctgccttc      180

cgggacagca gcctggagaa tgagattgct gtgttgaaaa agatcaagca tgaaaacatt      240

gtgaccctgg aggacatcta tgagagcacc acccactact acctggtcat gcagcttgtt      300

tctggtgggg agctctttga ccggatcctg gagcggggtg tctacacaga gaaggatgcc      360

agtctggtga tccagcaggt cttgtcggca gtgaaatacc tacatgagaa tggcatcgtc      420

cacagagact taaagcccga aaacctgctt taccttaccc ctgaagagaa ctctaagatc      480

atgatcactg actttggtct gtccaagatg gaacagaatg gcatcatgtc cactgcctgt      540

gggaccccag gctacgtggc tccagaagtg ctggcccaga aaccctacag caaggctgtg      600

gattgctggt ccatcggcgt catcacctac atattgctct gtggataccc cccattctat      660

gaagaaacgg agtctaagct tttcgagaag atcaaggagg gctactatga gtttgagtct      720

ccattctggg atgacatttc tgagtcagcc aaggacttta tttgccactt gcttgagaag      780

gatccgaacg agcggtacac ctgtgagaag gccttgagtc atccctggat tgacggaaac      840

acagccctcc accgggacat ctacccatca gtcagcctcc agatccagaa gaactttgct      900

aagagcaagt ggaggcaagc cttcaacgca gcagctgtgg tgcaccacat gaggaagcta      960

cacatgaacc tgcacagccc gggcgtccgc ccagaggtgg agaacaggcc gcctgaaact     1020

caagcctcag aaacctctag acccagctcc cctgagatca ccatcaccga ggcacctgtc     1080

ctggaccaca gtgtagcact ccctgccctg acccaattac cctgccagca tggccgccgg     1140

cccactgccc ctggtggcag gtccctcaac tgcctggtca atggctccct ccacatcagc     1200

agcagcctgg tgcccatgca tcaggggtcc ctggccgccg ggccctgtgg ctgctgctcc     1260

agctgcctga acattgggag caaaggaaag tcctcctact gctctgagcc cacactcctc     1320

aaaaaggcca acaaaaaaca gaacttcaag tcggaggtca tggtaccagt taaagccagt     1380

ggcagctccc actgccgggc agggcagact ggagtctgtc tcattatgtg a              1431


<210>  282
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Gly Arg Lys Glu Glu Asp Asp Cys Ser Ser Trp Lys Lys Gln Thr 
1               5                   10                  15      


Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Leu Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
    50                  55                  60                  


Leu Glu Asn Glu Ile Ala Val Leu Lys Lys Ile Lys His Glu Asn Ile 
65                  70                  75                  80  


Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                85                  90                  95      


Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
            100                 105                 110         


Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
        115                 120                 125             


Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
    130                 135                 140                 


Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
145                 150                 155                 160 


Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Ile Met 
                165                 170                 175     


Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
            180                 185                 190         


Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
        195                 200                 205             


Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
    210                 215                 220                 


Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
225                 230                 235                 240 


Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                245                 250                 255     


Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
            260                 265                 270         


Ser His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
        275                 280                 285             


Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
    290                 295                 300                 


Arg Gln Ala Phe Asn Ala Ala Ala Val Val His His Met Arg Lys Leu 
305                 310                 315                 320 


His Met Asn Leu His Ser Pro Gly Val Arg Pro Glu Val Glu Asn Arg 
                325                 330                 335     


Pro Pro Glu Thr Gln Ala Ser Glu Thr Ser Arg Pro Ser Ser Pro Glu 
            340                 345                 350         


Ile Thr Ile Thr Glu Ala Pro Val Leu Asp His Ser Val Ala Leu Pro 
        355                 360                 365             


Ala Leu Thr Gln Leu Pro Cys Gln His Gly Arg Arg Pro Thr Ala Pro 
    370                 375                 380                 


Gly Gly Arg Ser Leu Asn Cys Leu Val Asn Gly Ser Leu His Ile Ser 
385                 390                 395                 400 


Ser Ser Leu Val Pro Met His Gln Gly Ser Leu Ala Ala Gly Pro Cys 
                405                 410                 415     


Gly Cys Cys Ser Ser Cys Leu Asn Ile Gly Ser Lys Gly Lys Ser Ser 
            420                 425                 430         


Tyr Cys Ser Glu Pro Thr Leu Leu Lys Lys Ala Asn Lys Lys Gln Asn 
        435                 440                 445             


Phe Lys Ser Glu Val Met Val Pro Val Lys Ala Ser Gly Ser Ser His 
    450                 455                 460                 


Cys Arg Ala Gly Gln Thr Gly Val Cys Leu Ile Met 
465                 470                 475     


<210>  283
<211>  6075
<212>  DNA
<213>  Homo sapiens

<400>  283
atggccacag gaggaggtcc ctttgaagat ggcatgaatg atcaggattt accaaactgg       60

agtaatgaga atgttgatga caggctcaac aatatggatt ggggtgccca acagaagaaa      120

gcaaatagat catcagaaaa gaataagaaa aagtttggtg tagaaagtga taaaagagta      180

accaatgata tttctccgga gtcgtcacca ggagttggaa ggcgaagaac aaagactcca      240

catacgttcc cacacagtag atacatgagt cagatgtctg tcccagagca ggcagaatta      300

gagaaactga aacagcggat aaacttcagt gatttagatc agagaagcat tggaagtgat      360

tcccaaggta gagcaacagc tgctaacaac aaacgtcagc ttagtgaaaa ccgaaagccc      420

ttcaactttt tgcctatgca gattaatact aacaagagca aagatgcatc tacaagtccc      480

ccaaacagag aaacgattgg atcagcacag tgtaaagagt tgtttgcttc tgctttaagt      540

aatgacctct tgcaaaactg tcaggtgtct gaagaagatg ggaggggaga acctgcaatg      600

gagagcagcc agattgtaag caggcttgtt caaattcgcg attatattac taaagctagt      660

tccatgcggg aagatcttgt agagaaaaat gagagatctg ctaatgttga gcgccttact      720

catctaatag atcaccttaa agaacaagag aagtcatata tgaaatttct taaaaaaatc      780

cttgccagag atcctcagca ggagcctatg gaagagatag aaaatttgaa gaaacaacat      840

gatttattaa aaagaatgtt acaacagcag gagcaactaa gagctctaca gggacggcag      900

gctgcacttc tagctctgca acataaagca gagcaagcta ttgcagtgat ggatgattct      960

gttgttgcag aaactgcagg tagcttatct ggcgtcagta tcacatctga actaaatgaa     1020

gaattgaatg acttaattca gcgttttcat aatcagcttc gtgattctca gcctccagct     1080

gttccagaca atagaagaca ggcagaaagt ctttcattaa ctagggaggt ttcccagagc     1140

aggaaaccat cagcttcaga acgtttacct gatgagaaag tcgaactttt tagcaaaatg     1200

agagtgctac aggaaaagaa acaaaaaatg gacaaattgc ttggagaact tcatacactt     1260

cgagatcagc atcttaacaa ttcatcatcc tctccacaaa ggagtgtcga tcagagaagt     1320

acttcagctc cctctgcttc tgtaggcttg gcaccggttg tcaatggaga atccaatagc     1380

ctcacatcat ctgttcctta tcctactgct tctctagtat ctcagaatga gagtgaaaac     1440

gaaggccacc tcaatccatc tgaaaaactc cagaagttaa atgaagttcg aaagagattg     1500

aatgagctaa gagaattagt tcattattat gaacaaacgt cagacatgat gacagatgct     1560

gtgaatgaaa acaggaaaga tgaagaaact gaagagtcag aatatgattc tgagcatgaa     1620

aattccgagc ctgttactaa cattcgaaat ccacaagtag cttccacttg gaatgaagta     1680

aatagtcata gtaatgcaca gtgtgtttct aataatagag atgggcgaac agttaattct     1740

aattgtgaaa ttaacaacag atctgctgcc aacataaggg ctctaaacat gcctccttct     1800

ttagattgtc gatataatag agaaggggaa caggagattc atgttgcaca aggtgaagat     1860

gatgaggagg aggaggaaga agcagaagag gagggagtca gtggagcttc attatctagt     1920

cacaggagca gtctggttga tgagcatcca gaagatgctg aatttgaaca gaagatcaac     1980

cgacttatgg ctgcaaaaca gaaacttaga cagttacaag atcttgttgc tatggtacag     2040

gatgatgatg cagctcaagg agttatctct gccagtgcat caaatttgga tgatttctac     2100

ccagcagaag aagacaccaa gcaaaattca aataacacta gaggaaatgc caataaaaca     2160

cagaaagata ctggagtaaa tgaaaaggca agagagaaat tttatgaggc taaactacag     2220

cagcaacaga gagagctaaa acaattgcag gaagaaagaa agaaactgat tgacattcag     2280

gagaaaattc aagcattgca aacggcatgc cctgacttac agctgtcagc tgctagtgtg     2340

ggtaactgtc ccaccaaaaa atatatgcca gctgttactt caaccccaac tgttaatcaa     2400

cacgagacca gtacaagcaa atctgttttt gagcctgaag attcttcaat agtagataat     2460

gagttgtggt cagaaatgag aagacatgaa atgttgaggg aggagctgcg acagagaaga     2520

aagcagcttg aagctctgat ggctgaacat cagaggaggc aaggtctagc tgaaactgca     2580

tctccagtgg ctgtgtcatt gagaagtgat ggatctgaga acctatgtac tcctcagcaa     2640

agtagaacag aaaaaacgat ggcaacttgg ggagggtcta cccagtgtgc actagatgaa     2700

gaaggagatg aagacggtta cctttctgaa ggaattgttc ggacagatga agaggaggaa     2760

gaagagcaag atgccagttc caatgataac ttttctgtgt gtccttctaa cagtgtgaat     2820

cataactcct acaatggaaa ggaaactaaa aataggtgga agaacaattg ccctttttcg     2880

gcagatgaaa attatcgtcc tttagccaag acaaggcaac agaatatcag catgcaacgg     2940

caagaaaacc ttcgttgggt gtcagagctc tcttacgtag aagagaaaga acaatggcaa     3000

gaacaaatca atcagctaaa gaaacagctt gattttagtg tcagtatttg tcagactttg     3060

atgcaagacc agcagactct atcttgtctg ctacaaactc ttctcacggg tccttacagt     3120

gttatgccca gcaatgttgc atctcctcaa gtacacttca taatgcacca gttgaaccag     3180

tgctatactc agctaacatg gcaacagaat aatgttcaga ggttgaaaca aatgctaaat     3240

gaacttatgc gccagcaaaa tcagcatcca gaaaaacctg gaggcaagga aagaggcagt     3300

agtgcatcgc accctccttc tcccagttta ttttgtcctt tcagctttcc aacacagcct     3360

gtaaatctct tcaatatacc tggatttact aacttttcat catttgcacc aggtatgaat     3420

ttcagccctt tatttccttc taattttgga gatttttctc agaatatctc tacacccagt     3480

gaacagcagc aacccttagc ccagaattct tcaggaaaaa cagaatatat ggcttttcca     3540

aaaccttttg aaagcagttc ctctattgga gcagagaaac caaggaataa aaaactgcct     3600

gaagaggagg tggaaagcag taggacacca tggttatatg aacaagaagg tgaagtagag     3660

aaaccattta tcaagactgg attttcagtg tctgtagaaa aatctacaag tagtaaccgc     3720

aaaaatcaat tagatacaaa cggaagaaga cgccagtttg atgaagaatc actggaaagc     3780

tttagcagta tgcctgatcc agtagatcca acaacagtga ctaaaacatt caagacaaga     3840

aaagcgtctg cacaggccag cctggcatct aaagataaaa ctcccaagtc aaaaagtaag     3900

aagaggaatt ctactcagct gaaaagcaga gttaaaaaca tcaggtatga aagtgccagt     3960

atgtctagca catgtgaacc ttgcaaaagt aggaacagac attcagccca gactgaagag     4020

cctgttcaag caaaagtatt cagcagaaag aatcatgagc aactggaaaa aataataaaa     4080

tgtaataggt ctacagaaat atcttcagaa actgggagtg atttttccat gtttgaagct     4140

ttgcgagata ctatttattc tgaagtagct acattaattt ctcaaaatga atctcgtcca     4200

cattttctta ttgaactctt ccatgagctg cagctactaa acacagacta cttgagacag     4260

agggctttat atgcattgca ggacatagta tccagacata tttctgagag ccatgaaaaa     4320

ggagaaaatg taaagtcagt aaactctggt acttggatag catcaaactc agaacttact     4380

cctagtgaga gccttgctac tactgatgat gaaacttttg agaagaactt tgaaagagaa     4440

acccataaaa taagtgagca aaatgatgct gataatgcta gtgtcctgtc tgtatcatca     4500

aattttgagc cttttgcaac agatgatcta ggtaacaccg tgattcactt agatcaagca     4560

ttagccagaa tgagagaata tgagcgtatg aagactgagg ctgaaagtaa ctcaaatatg     4620

agatgcacct gcaggattat tgaggatgga gatggtgctg gtgcaggtac tacagttaat     4680

aatttagaag aaactcccgt tattgaaaat cgtagttcac aacaacctgt aagtgaagtt     4740

tctaccatcc catgtcctag aattgatact cagcagctgg accggcaaat taaagcaatt     4800

atgaaagaag tcattccttt tttgaaggag cacatggatg aagtatgctc ctcgcagctt     4860

ctaacttcag taaggcgcat ggttttgacc cttacccagc aaaatgatga gagcaaagag     4920

tttgtaaagt tctttcataa acaacttgga agtatattac aggattcact ggcaaaattt     4980

gctggcagaa aactgaaaga ctgtggagaa gatcttcttg tagagatatc tgaagtgttg     5040

ttcaatgaat tggctttctt taagcttatg caagatttgg ataataatag tataactgtt     5100

aaacagagat gcaaaaggaa aatagaagca actggagtga tacaatcttg tgccaaagag     5160

gctaaaagga ttcttgaaga tcatggctca cctgctggag agattgatga tgaagacaaa     5220

gacaaggatg aaactgaaac agttaagcag actcaaacat ctgaggtgta tgatggtccc     5280

aaaaatgtaa gatctgatat ttctgatcaa gaggaagatg aagaaagtga aggatgtcca     5340

gtgtctatta atttgtctaa agctgaaact caggctttaa ctaattatgg aagtggagaa     5400

gatgaaaatg aggatgaaga aatggaagaa tttgaagaag gccctgtgga tgtccagact     5460

tccctccagg ctaacactga agctactgaa gaaaatgaac atgatgaaca ggtcctacaa     5520

cgtgacttta aaaagacagc agaaagcaaa aatgtcccat tggaacgaga agccactagt     5580

aaaaatgacc aaaataactg tcctgtgaaa ccctgttacc tcaatatctt ggaagatgag     5640

caacctttaa atagtgctgc ccataaggag tcacctccta ctgttgattc aactcaacag     5700

cctaaccctt tgccgttacg tttacctgaa atggaaccct tagtgcctag agtcaaagaa     5760

gttaaatctg ctcaggaaac tcctgaaagc tctctggctg gaagtcctga tactgaatct     5820

ccagtgttag tgaatgacta tgaagcagaa tctggtaata taagtcaaaa gtctgatgaa     5880

gaagattttg taaaagttga agatttacca ctgaaactga caatatattc agaggcagat     5940

ctaagaaaga aaatggtaga agaagaacag aaaaaccatt tatctggtga aatatgtgaa     6000

atgcagaccg aagaattagc tggaaattct gagacactaa aagaacctga aacggtggga     6060

gcccagagta tatga                                                      6075


<210>  284
<211>  2024
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp 
1               5                   10                  15      


Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met 
            20                  25                  30          


Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn 
        35                  40                  45              


Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile 
    50                  55                  60                  


Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro 
65                  70                  75                  80  


His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu 
                85                  90                  95      


Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu 
            100                 105                 110         


Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala 
        115                 120                 125             


Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu 
    130                 135                 140                 


Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro 
145                 150                 155                 160 


Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala 
                165                 170                 175     


Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu 
            180                 185                 190         


Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg 
        195                 200                 205             


Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu 
    210                 215                 220                 


Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr 
225                 230                 235                 240 


His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe 
                245                 250                 255     


Leu Lys Lys Ile Leu Ala Arg Asp Pro Gln Gln Glu Pro Met Glu Glu 
            260                 265                 270         


Ile Glu Asn Leu Lys Lys Gln His Asp Leu Leu Lys Arg Met Leu Gln 
        275                 280                 285             


Gln Gln Glu Gln Leu Arg Ala Leu Gln Gly Arg Gln Ala Ala Leu Leu 
    290                 295                 300                 


Ala Leu Gln His Lys Ala Glu Gln Ala Ile Ala Val Met Asp Asp Ser 
305                 310                 315                 320 


Val Val Ala Glu Thr Ala Gly Ser Leu Ser Gly Val Ser Ile Thr Ser 
                325                 330                 335     


Glu Leu Asn Glu Glu Leu Asn Asp Leu Ile Gln Arg Phe His Asn Gln 
            340                 345                 350         


Leu Arg Asp Ser Gln Pro Pro Ala Val Pro Asp Asn Arg Arg Gln Ala 
        355                 360                 365             


Glu Ser Leu Ser Leu Thr Arg Glu Val Ser Gln Ser Arg Lys Pro Ser 
    370                 375                 380                 


Ala Ser Glu Arg Leu Pro Asp Glu Lys Val Glu Leu Phe Ser Lys Met 
385                 390                 395                 400 


Arg Val Leu Gln Glu Lys Lys Gln Lys Met Asp Lys Leu Leu Gly Glu 
                405                 410                 415     


Leu His Thr Leu Arg Asp Gln His Leu Asn Asn Ser Ser Ser Ser Pro 
            420                 425                 430         


Gln Arg Ser Val Asp Gln Arg Ser Thr Ser Ala Pro Ser Ala Ser Val 
        435                 440                 445             


Gly Leu Ala Pro Val Val Asn Gly Glu Ser Asn Ser Leu Thr Ser Ser 
    450                 455                 460                 


Val Pro Tyr Pro Thr Ala Ser Leu Val Ser Gln Asn Glu Ser Glu Asn 
465                 470                 475                 480 


Glu Gly His Leu Asn Pro Ser Glu Lys Leu Gln Lys Leu Asn Glu Val 
                485                 490                 495     


Arg Lys Arg Leu Asn Glu Leu Arg Glu Leu Val His Tyr Tyr Glu Gln 
            500                 505                 510         


Thr Ser Asp Met Met Thr Asp Ala Val Asn Glu Asn Arg Lys Asp Glu 
        515                 520                 525             


Glu Thr Glu Glu Ser Glu Tyr Asp Ser Glu His Glu Asn Ser Glu Pro 
    530                 535                 540                 


Val Thr Asn Ile Arg Asn Pro Gln Val Ala Ser Thr Trp Asn Glu Val 
545                 550                 555                 560 


Asn Ser His Ser Asn Ala Gln Cys Val Ser Asn Asn Arg Asp Gly Arg 
                565                 570                 575     


Thr Val Asn Ser Asn Cys Glu Ile Asn Asn Arg Ser Ala Ala Asn Ile 
            580                 585                 590         


Arg Ala Leu Asn Met Pro Pro Ser Leu Asp Cys Arg Tyr Asn Arg Glu 
        595                 600                 605             


Gly Glu Gln Glu Ile His Val Ala Gln Gly Glu Asp Asp Glu Glu Glu 
    610                 615                 620                 


Glu Glu Glu Ala Glu Glu Glu Gly Val Ser Gly Ala Ser Leu Ser Ser 
625                 630                 635                 640 


His Arg Ser Ser Leu Val Asp Glu His Pro Glu Asp Ala Glu Phe Glu 
                645                 650                 655     


Gln Lys Ile Asn Arg Leu Met Ala Ala Lys Gln Lys Leu Arg Gln Leu 
            660                 665                 670         


Gln Asp Leu Val Ala Met Val Gln Asp Asp Asp Ala Ala Gln Gly Val 
        675                 680                 685             


Ile Ser Ala Ser Ala Ser Asn Leu Asp Asp Phe Tyr Pro Ala Glu Glu 
    690                 695                 700                 


Asp Thr Lys Gln Asn Ser Asn Asn Thr Arg Gly Asn Ala Asn Lys Thr 
705                 710                 715                 720 


Gln Lys Asp Thr Gly Val Asn Glu Lys Ala Arg Glu Lys Phe Tyr Glu 
                725                 730                 735     


Ala Lys Leu Gln Gln Gln Gln Arg Glu Leu Lys Gln Leu Gln Glu Glu 
            740                 745                 750         


Arg Lys Lys Leu Ile Asp Ile Gln Glu Lys Ile Gln Ala Leu Gln Thr 
        755                 760                 765             


Ala Cys Pro Asp Leu Gln Leu Ser Ala Ala Ser Val Gly Asn Cys Pro 
    770                 775                 780                 


Thr Lys Lys Tyr Met Pro Ala Val Thr Ser Thr Pro Thr Val Asn Gln 
785                 790                 795                 800 


His Glu Thr Ser Thr Ser Lys Ser Val Phe Glu Pro Glu Asp Ser Ser 
                805                 810                 815     


Ile Val Asp Asn Glu Leu Trp Ser Glu Met Arg Arg His Glu Met Leu 
            820                 825                 830         


Arg Glu Glu Leu Arg Gln Arg Arg Lys Gln Leu Glu Ala Leu Met Ala 
        835                 840                 845             


Glu His Gln Arg Arg Gln Gly Leu Ala Glu Thr Ala Ser Pro Val Ala 
    850                 855                 860                 


Val Ser Leu Arg Ser Asp Gly Ser Glu Asn Leu Cys Thr Pro Gln Gln 
865                 870                 875                 880 


Ser Arg Thr Glu Lys Thr Met Ala Thr Trp Gly Gly Ser Thr Gln Cys 
                885                 890                 895     


Ala Leu Asp Glu Glu Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly Ile 
            900                 905                 910         


Val Arg Thr Asp Glu Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser Asn 
        915                 920                 925             


Asp Asn Phe Ser Val Cys Pro Ser Asn Ser Val Asn His Asn Ser Tyr 
    930                 935                 940                 


Asn Gly Lys Glu Thr Lys Asn Arg Trp Lys Asn Asn Cys Pro Phe Ser 
945                 950                 955                 960 


Ala Asp Glu Asn Tyr Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn Ile 
                965                 970                 975     


Ser Met Gln Arg Gln Glu Asn Leu Arg Trp Val Ser Glu Leu Ser Tyr 
            980                 985                 990         


Val Glu Glu Lys Glu Gln Trp Gln  Glu Gln Ile Asn Gln  Leu Lys Lys 
        995                 1000                 1005             


Gln Leu  Asp Phe Ser Val Ser  Ile Cys Gln Thr Leu  Met Gln Asp 
    1010                 1015                 1020             


Gln Gln  Thr Leu Ser Cys Leu  Leu Gln Thr Leu Leu  Thr Gly Pro 
    1025                 1030                 1035             


Tyr Ser  Val Met Pro Ser Asn  Val Ala Ser Pro Gln  Val His Phe 
    1040                 1045                 1050             


Ile Met  His Gln Leu Asn Gln  Cys Tyr Thr Gln Leu  Thr Trp Gln 
    1055                 1060                 1065             


Gln Asn  Asn Val Gln Arg Leu  Lys Gln Met Leu Asn  Glu Leu Met 
    1070                 1075                 1080             


Arg Gln  Gln Asn Gln His Pro  Glu Lys Pro Gly Gly  Lys Glu Arg 
    1085                 1090                 1095             


Gly Ser  Ser Ala Ser His Pro  Pro Ser Pro Ser Leu  Phe Cys Pro 
    1100                 1105                 1110             


Phe Ser  Phe Pro Thr Gln Pro  Val Asn Leu Phe Asn  Ile Pro Gly 
    1115                 1120                 1125             


Phe Thr  Asn Phe Ser Ser Phe  Ala Pro Gly Met Asn  Phe Ser Pro 
    1130                 1135                 1140             


Leu Phe  Pro Ser Asn Phe Gly  Asp Phe Ser Gln Asn  Ile Ser Thr 
    1145                 1150                 1155             


Pro Ser  Glu Gln Gln Gln Pro  Leu Ala Gln Asn Ser  Ser Gly Lys 
    1160                 1165                 1170             


Thr Glu  Tyr Met Ala Phe Pro  Lys Pro Phe Glu Ser  Ser Ser Ser 
    1175                 1180                 1185             


Ile Gly  Ala Glu Lys Pro Arg  Asn Lys Lys Leu Pro  Glu Glu Glu 
    1190                 1195                 1200             


Val Glu  Ser Ser Arg Thr Pro  Trp Leu Tyr Glu Gln  Glu Gly Glu 
    1205                 1210                 1215             


Val Glu  Lys Pro Phe Ile Lys  Thr Gly Phe Ser Val  Ser Val Glu 
    1220                 1225                 1230             


Lys Ser  Thr Ser Ser Asn Arg  Lys Asn Gln Leu Asp  Thr Asn Gly 
    1235                 1240                 1245             


Arg Arg  Arg Gln Phe Asp Glu  Glu Ser Leu Glu Ser  Phe Ser Ser 
    1250                 1255                 1260             


Met Pro  Asp Pro Val Asp Pro  Thr Thr Val Thr Lys  Thr Phe Lys 
    1265                 1270                 1275             


Thr Arg  Lys Ala Ser Ala Gln  Ala Ser Leu Ala Ser  Lys Asp Lys 
    1280                 1285                 1290             


Thr Pro  Lys Ser Lys Ser Lys  Lys Arg Asn Ser Thr  Gln Leu Lys 
    1295                 1300                 1305             


Ser Arg  Val Lys Asn Ile Arg  Tyr Glu Ser Ala Ser  Met Ser Ser 
    1310                 1315                 1320             


Thr Cys  Glu Pro Cys Lys Ser  Arg Asn Arg His Ser  Ala Gln Thr 
    1325                 1330                 1335             


Glu Glu  Pro Val Gln Ala Lys  Val Phe Ser Arg Lys  Asn His Glu 
    1340                 1345                 1350             


Gln Leu  Glu Lys Ile Ile Lys  Cys Asn Arg Ser Thr  Glu Ile Ser 
    1355                 1360                 1365             


Ser Glu  Thr Gly Ser Asp Phe  Ser Met Phe Glu Ala  Leu Arg Asp 
    1370                 1375                 1380             


Thr Ile  Tyr Ser Glu Val Ala  Thr Leu Ile Ser Gln  Asn Glu Ser 
    1385                 1390                 1395             


Arg Pro  His Phe Leu Ile Glu  Leu Phe His Glu Leu  Gln Leu Leu 
    1400                 1405                 1410             


Asn Thr  Asp Tyr Leu Arg Gln  Arg Ala Leu Tyr Ala  Leu Gln Asp 
    1415                 1420                 1425             


Ile Val  Ser Arg His Ile Ser  Glu Ser His Glu Lys  Gly Glu Asn 
    1430                 1435                 1440             


Val Lys  Ser Val Asn Ser Gly  Thr Trp Ile Ala Ser  Asn Ser Glu 
    1445                 1450                 1455             


Leu Thr  Pro Ser Glu Ser Leu  Ala Thr Thr Asp Asp  Glu Thr Phe 
    1460                 1465                 1470             


Glu Lys  Asn Phe Glu Arg Glu  Thr His Lys Ile Ser  Glu Gln Asn 
    1475                 1480                 1485             


Asp Ala  Asp Asn Ala Ser Val  Leu Ser Val Ser Ser  Asn Phe Glu 
    1490                 1495                 1500             


Pro Phe  Ala Thr Asp Asp Leu  Gly Asn Thr Val Ile  His Leu Asp 
    1505                 1510                 1515             


Gln Ala  Leu Ala Arg Met Arg  Glu Tyr Glu Arg Met  Lys Thr Glu 
    1520                 1525                 1530             


Ala Glu  Ser Asn Ser Asn Met  Arg Cys Thr Cys Arg  Ile Ile Glu 
    1535                 1540                 1545             


Asp Gly  Asp Gly Ala Gly Ala  Gly Thr Thr Val Asn  Asn Leu Glu 
    1550                 1555                 1560             


Glu Thr  Pro Val Ile Glu Asn  Arg Ser Ser Gln Gln  Pro Val Ser 
    1565                 1570                 1575             


Glu Val  Ser Thr Ile Pro Cys  Pro Arg Ile Asp Thr  Gln Gln Leu 
    1580                 1585                 1590             


Asp Arg  Gln Ile Lys Ala Ile  Met Lys Glu Val Ile  Pro Phe Leu 
    1595                 1600                 1605             


Lys Glu  His Met Asp Glu Val  Cys Ser Ser Gln Leu  Leu Thr Ser 
    1610                 1615                 1620             


Val Arg  Arg Met Val Leu Thr  Leu Thr Gln Gln Asn  Asp Glu Ser 
    1625                 1630                 1635             


Lys Glu  Phe Val Lys Phe Phe  His Lys Gln Leu Gly  Ser Ile Leu 
    1640                 1645                 1650             


Gln Asp  Ser Leu Ala Lys Phe  Ala Gly Arg Lys Leu  Lys Asp Cys 
    1655                 1660                 1665             


Gly Glu  Asp Leu Leu Val Glu  Ile Ser Glu Val Leu  Phe Asn Glu 
    1670                 1675                 1680             


Leu Ala  Phe Phe Lys Leu Met  Gln Asp Leu Asp Asn  Asn Ser Ile 
    1685                 1690                 1695             


Thr Val  Lys Gln Arg Cys Lys  Arg Lys Ile Glu Ala  Thr Gly Val 
    1700                 1705                 1710             


Ile Gln  Ser Cys Ala Lys Glu  Ala Lys Arg Ile Leu  Glu Asp His 
    1715                 1720                 1725             


Gly Ser  Pro Ala Gly Glu Ile  Asp Asp Glu Asp Lys  Asp Lys Asp 
    1730                 1735                 1740             


Glu Thr  Glu Thr Val Lys Gln  Thr Gln Thr Ser Glu  Val Tyr Asp 
    1745                 1750                 1755             


Gly Pro  Lys Asn Val Arg Ser  Asp Ile Ser Asp Gln  Glu Glu Asp 
    1760                 1765                 1770             


Glu Glu  Ser Glu Gly Cys Pro  Val Ser Ile Asn Leu  Ser Lys Ala 
    1775                 1780                 1785             


Glu Thr  Gln Ala Leu Thr Asn  Tyr Gly Ser Gly Glu  Asp Glu Asn 
    1790                 1795                 1800             


Glu Asp  Glu Glu Met Glu Glu  Phe Glu Glu Gly Pro  Val Asp Val 
    1805                 1810                 1815             


Gln Thr  Ser Leu Gln Ala Asn  Thr Glu Ala Thr Glu  Glu Asn Glu 
    1820                 1825                 1830             


His Asp  Glu Gln Val Leu Gln  Arg Asp Phe Lys Lys  Thr Ala Glu 
    1835                 1840                 1845             


Ser Lys  Asn Val Pro Leu Glu  Arg Glu Ala Thr Ser  Lys Asn Asp 
    1850                 1855                 1860             


Gln Asn  Asn Cys Pro Val Lys  Pro Cys Tyr Leu Asn  Ile Leu Glu 
    1865                 1870                 1875             


Asp Glu  Gln Pro Leu Asn Ser  Ala Ala His Lys Glu  Ser Pro Pro 
    1880                 1885                 1890             


Thr Val  Asp Ser Thr Gln Gln  Pro Asn Pro Leu Pro  Leu Arg Leu 
    1895                 1900                 1905             


Pro Glu  Met Glu Pro Leu Val  Pro Arg Val Lys Glu  Val Lys Ser 
    1910                 1915                 1920             


Ala Gln  Glu Thr Pro Glu Ser  Ser Leu Ala Gly Ser  Pro Asp Thr 
    1925                 1930                 1935             


Glu Ser  Pro Val Leu Val Asn  Asp Tyr Glu Ala Glu  Ser Gly Asn 
    1940                 1945                 1950             


Ile Ser  Gln Lys Ser Asp Glu  Glu Asp Phe Val Lys  Val Glu Asp 
    1955                 1960                 1965             


Leu Pro  Leu Lys Leu Thr Ile  Tyr Ser Glu Ala Asp  Leu Arg Lys 
    1970                 1975                 1980             


Lys Met  Val Glu Glu Glu Gln  Lys Asn His Leu Ser  Gly Glu Ile 
    1985                 1990                 1995             


Cys Glu  Met Gln Thr Glu Glu  Leu Ala Gly Asn Ser  Glu Thr Leu 
    2000                 2005                 2010             


Lys Glu  Pro Glu Thr Val Gly  Ala Gln Ser Ile 
    2015                 2020                 


<210>  285
<211>  2856
<212>  DNA
<213>  Homo sapiens

<400>  285
atgtacggcg cgagcggggg ccgcgccaaa cccgagagga aaagcggcgc gaaggaggag       60

gccgggccag gcggtgccgg cggtgggggc agccgagtgg agctcttggt tttcggctat      120

gcctgcaagc tgttccggga cgacgagcgg gccctggctc aggaacaggg acagcacctc      180

atcccctgga tgggggacca caagatcctc atcgacagat atgatggacg tggtcacctg      240

catgaccttt ctgagtacga tgctgagtat tccacgtgga acagagatta tcagctgtct      300

gaagaggagg cgcgaataga ggccctgtgt gatgaagaga ggtatttagc cttgcatacg      360

gacttgcttg aggaggaggc aaggcaagag gaagaataca agcgattgag tgaagcacta      420

gcagaggatg ggagctacaa tgccgtgggg ttcacttacg gtagcgacta ttacgacccg      480

tcagagccga cggaggagga ggagccttcc aaacagagag aaaaaaatga ggccgaaaat      540

ttagaggaaa atgaagagcc cttcgttgcc cccttaggat tgagcgtccc gtctgacgtg      600

gagttgccac caaccgctaa aatgcacgcc atcatcgagc gcacggccag cttcgtgtgc      660

aggcagggag cacagtttga gatcatgctg aaggccaagc aggcccggaa ctcccagttt      720

gactttctgc gcttcgacca ctacctcaac ccctactata agttcatcca gaaagccatg      780

aaagagggac gctacactgt cctggcagaa aacaaaagtg acgagaaaaa aaaatcagga      840

gtcagctctg acaatgaaga tgatgatgat gaagaagatg ggaattacct tcatccctct      900

ctctttgcct ccaagaagtg taaccgcctt gaagagctga tgaagccctt gaaggtagtg      960

gacccagatc atcccctcgc agcacttgtt cgtaaggcac aggctgacag ttccactccc     1020

accccacaca acgcagacgg tgcgcctgtg cagccctccc aggtggagta cacggcagac     1080

tcgaccgtgg cagccatgta ttacagctac tacatgctac cggacggcac ttactgcctg     1140

gcgccgcccc ctcccggaat cgacgtgact acttactaca gcacccttcc tgctggcgtg     1200

accgtgtcta actcccctgg agtgacgacc accgccccac cacctcctgg gaccacacca     1260

ctaccgcccc caaccacagc agagactagc agcggggcca cctccacaac caccaccaca     1320

agtgcacttg cccccgtggc cgccatcatc cccccgcccc ccgacgtcca gcccgtgatt     1380

gacaagctgg ccgagtatgt cgccaggaac ggcctgaagt tcgagaccag tgttcgtgcc     1440

aagaatgatc aaagatttga gttcctgcag ccgtggcacc agtataatgc ttattatgag     1500

tttaagaagc agttcttcct ccagaaagaa gggggcgata gcatgcaggc tgtgtctgca     1560

ccagaagagg ctcccacaga ctctgctccc gagaagccaa gtgatgctgg ggaggatggc     1620

gcgcctgaag acgcagccga ggtgggagca cgggcaggct caggcgggaa gaaggaggca     1680

tcgtccagta agaccgtccc ggacgggaag ctggtgaaag cttcctttgc tccaataagc     1740

tttgcaatca aggccaaaga aaatgatctg cttcccctgg aaaaaaatcg tgttaagcta     1800

gatgatgaca gtgatgatga tgaagaaagc aaagaaggcc aagaaagttc tagtagtgct     1860

gcaaacacta acccagcagt tgccccaccc tgtgtagttg ttgaggagaa gaagcctcaa     1920

cttacccagg aggagctaga agcaaagcaa gcaaagcaaa agctggaaga tcgcctcgca     1980

gctgctgccc gggaaaagct ggcccaggcg tctaaggagt caaaagagaa acagcttcaa     2040

gcagaacgta aaaggaaagc ggcgttattt ttacagaccc tcaaaaatcc tctgccggaa     2100

gcagaagctg ggaaaattga ggagagtcct ttcagtgtcg aggaatccag cactacgccc     2160

tgccctctac tgactggagg caggcctctg cctactttag aagttaaacc acccgatagg     2220

ccttcgagca aaagcaaaga tccaccgaga gaagaagaga aagaaaagaa aaagaaaaag     2280

cacaaaaaaa gatctcgaac aagatcacgt tctcccaagt accattcgtc atccaagtcc     2340

aggtctagat cacactcaaa agcaaagcat tctcttccca gtgcctatcg gacagtgcgg     2400

cggtcgaggt cccgctcccg gtcccctcgg aggagagccc actcccctga gagacggagg     2460

gaagagagga gtgtgcccac tgcctaccgc gtgagccgca gccctggggc cagtaggaag     2520

cggacccgct ccagaagtcc ccacgagaag aagaagaaga ggcggtcccg gtcgcggacc     2580

aagtccaagg ccaggtctca gtcggtgtca cccagcaagc aggcagcgcc ccggcccgcg     2640

gcccccgcgg cccactcggc gcactcagcc agcgtctccc ctgtggagag tcggggctcc     2700

agccaggagc gctccagggg agtctctcag gaaaaagaag cccagatctc ttcagcaatc     2760

gtttcttccg tgcagagcaa aatcactcag gatctcatgg ccaaagtcag agcgatgctt     2820

gcagcttcca aaaacctgca aaccagcgct tcctga                               2856


<210>  286
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Tyr Gly Ala Ser Gly Gly Arg Ala Lys Pro Glu Arg Lys Ser Gly 
1               5                   10                  15      


Ala Lys Glu Glu Ala Gly Pro Gly Gly Ala Gly Gly Gly Gly Ser Arg 
            20                  25                  30          


Val Glu Leu Leu Val Phe Gly Tyr Ala Cys Lys Leu Phe Arg Asp Asp 
        35                  40                  45              


Glu Arg Ala Gln Ala Gln Glu Gln Gly Gln His Leu Ile Pro Trp Met 
    50                  55                  60                  


Gly Asp His Lys Ile Leu Ile Asp Arg Tyr Asp Gly Arg Gly His Leu 
65                  70                  75                  80  


His Asp Leu Ser Glu Tyr Asp Ala Glu Tyr Ser Thr Trp Asn Arg Asp 
                85                  90                  95      


Tyr Gln Leu Ser Glu Glu Glu Ala Arg Ile Glu Ala Leu Cys Asp Glu 
            100                 105                 110         


Glu Arg Tyr Leu Ala Leu His Thr Asp Leu Leu Glu Glu Glu Ala Arg 
        115                 120                 125             


Gln Glu Glu Glu Tyr Lys Arg Phe Ser Glu Ala Leu Ala Glu Asp Gly 
    130                 135                 140                 


Ser Tyr Asn Ala Val Gly Phe Thr Tyr Gly Ser Asp Tyr Tyr Asp Pro 
145                 150                 155                 160 


Ser Glu Pro Thr Glu Glu Glu Glu Pro Ser Lys Gln Arg Glu Lys Asn 
                165                 170                 175     


Glu Ala Glu Asn Leu Glu Glu Asn Glu Glu Pro Phe Val Ala Pro Leu 
            180                 185                 190         


Gly Leu Ser Val Pro Ser Asp Val Glu Leu Pro Pro Thr Ala Lys Met 
        195                 200                 205             


His Ala Ile Ile Glu Arg Thr Ala Ser Phe Val Cys Arg Gln Gly Ala 
    210                 215                 220                 


Gln Phe Glu Ile Met Leu Lys Ala Lys Gln Ala Arg Asn Ser Gln Phe 
225                 230                 235                 240 


Asp Phe Leu Arg Phe Asp His Tyr Leu Asn Pro Tyr Tyr Lys Phe Ile 
                245                 250                 255     


Gln Lys Ala Met Lys Glu Gly Arg Tyr Thr Val Leu Ala Glu Asn Lys 
            260                 265                 270         


Ser Asp Glu Lys Lys Lys Ser Gly Val Ser Ser Asp Asn Glu Asp Asp 
        275                 280                 285             


Asp Asp Glu Glu Asp Gly Asn Tyr Leu His Pro Ser Leu Phe Ala Ser 
    290                 295                 300                 


Lys Lys Cys Asn Arg Leu Glu Glu Leu Met Lys Pro Leu Lys Val Val 
305                 310                 315                 320 


Asp Pro Asp His Pro Leu Ala Ala Leu Val Arg Lys Ala Gln Ala Asp 
                325                 330                 335     


Ser Ser Thr Pro Thr Pro His Asn Ala Asp Gly Ala Pro Val Gln Pro 
            340                 345                 350         


Ser Gln Val Glu Tyr Thr Ala Asp Ser Thr Val Ala Ala Met Tyr Tyr 
        355                 360                 365             


Ser Tyr Tyr Met Leu Pro Asp Gly Thr Tyr Cys Leu Ala Pro Pro Pro 
    370                 375                 380                 


Pro Gly Ile Asp Val Thr Thr Tyr Tyr Ser Thr Leu Pro Ala Gly Val 
385                 390                 395                 400 


Thr Val Ser Asn Ser Pro Gly Val Thr Thr Thr Ala Pro Pro Pro Pro 
                405                 410                 415     


Gly Thr Thr Pro Pro Pro Pro Pro Thr Thr Ala Glu Thr Ser Ser Gly 
            420                 425                 430         


Ala Thr Ser Thr Thr Thr Thr Thr Ser Ala Leu Ala Pro Val Ala Ala 
        435                 440                 445             


Ile Ile Pro Pro Pro Pro Asp Val Gln Pro Val Ile Asp Lys Leu Ala 
    450                 455                 460                 


Glu Tyr Val Ala Arg Asn Gly Leu Lys Phe Glu Thr Ser Val Arg Ala 
465                 470                 475                 480 


Lys Asn Asp Gln Arg Phe Glu Phe Leu Gln Pro Trp His Gln Tyr Asn 
                485                 490                 495     


Ala Tyr Tyr Glu Phe Lys Lys Gln Phe Phe Leu Gln Lys Glu Gly Gly 
            500                 505                 510         


Asp Ser Met Gln Ala Val Ser Ala Pro Glu Glu Ala Pro Thr Asp Ser 
        515                 520                 525             


Ala Pro Glu Lys Pro Ser Asp Ala Gly Glu Asp Gly Ala Pro Glu Asp 
    530                 535                 540                 


Ala Ala Glu Val Gly Ala Arg Ala Gly Ser Gly Gly Lys Lys Glu Ala 
545                 550                 555                 560 


Ser Ser Ser Lys Thr Val Pro Asp Gly Lys Leu Val Lys Ala Ser Phe 
                565                 570                 575     


Ala Pro Ile Ser Phe Ala Ile Lys Ala Lys Glu Asn Asp Leu Leu Pro 
            580                 585                 590         


Leu Glu Lys Asn Arg Val Lys Leu Asp Asp Asp Ser Asp Asp Asp Glu 
        595                 600                 605             


Glu Ser Lys Glu Gly Gln Glu Ser Ser Ser Ser Ala Ala Asn Thr Asn 
    610                 615                 620                 


Pro Ala Val Ala Pro Pro Cys Val Val Val Glu Glu Lys Lys Pro Gln 
625                 630                 635                 640 


Leu Thr Gln Glu Glu Leu Glu Ala Lys Gln Ala Lys Gln Lys Leu Glu 
                645                 650                 655     


Asp Arg Leu Ala Ala Ala Ala Arg Glu Lys Leu Ala Gln Ala Ser Lys 
            660                 665                 670         


Glu Ser Lys Glu Lys Gln Leu Gln Ala Glu Arg Lys Arg Lys Ala Ala 
        675                 680                 685             


Leu Phe Leu Gln Thr Leu Lys Asn Pro Leu Pro Glu Ala Glu Ala Gly 
    690                 695                 700                 


Lys Ile Glu Glu Ser Pro Phe Ser Val Glu Glu Ser Ser Thr Thr Pro 
705                 710                 715                 720 


Cys Pro Leu Leu Thr Gly Gly Arg Pro Leu Pro Thr Leu Glu Val Lys 
                725                 730                 735     


Pro Pro Asp Arg Pro Ser Ser Lys Ser Lys Asp Pro Pro Arg Glu Glu 
            740                 745                 750         


Glu Lys Glu Lys Lys Lys Lys Lys His Lys Lys Arg Ser Arg Thr Arg 
        755                 760                 765             


Ser Arg Ser Pro Lys Tyr His Ser Ser Ser Lys Ser Arg Ser Arg Ser 
    770                 775                 780                 


His Ser Lys Ala Lys His Ser Leu Pro Ser Ala Tyr Arg Thr Val Arg 
785                 790                 795                 800 


Arg Ser Arg Ser Arg Ser Arg Ser Pro Arg Arg Arg Ala His Ser Pro 
                805                 810                 815     


Glu Arg Arg Arg Glu Glu Arg Ser Val Pro Thr Ala Tyr Arg Val Ser 
            820                 825                 830         


Arg Ser Pro Gly Ala Ser Arg Lys Arg Thr Arg Ser Arg Ser Pro His 
        835                 840                 845             


Glu Lys Lys Lys Lys Arg Arg Ser Arg Ser Arg Thr Lys Ser Lys Ala 
    850                 855                 860                 


Arg Ser Gln Ser Val Ser Pro Ser Lys Gln Ala Ala Pro Arg Pro Ala 
865                 870                 875                 880 


Ala Pro Ala Ala His Ser Ala His Ser Ala Ser Val Ser Pro Val Glu 
                885                 890                 895     


Ser Arg Gly Ser Ser Gln Glu Arg Ser Arg Gly Val Ser Gln Glu Lys 
            900                 905                 910         


Glu Ala Gln Ile Ser Ser Ala Ile Val Ser Ser Val Gln Ser Lys Ile 
        915                 920                 925             


Thr Gln Asp Leu Met Ala Lys Val Arg Ala Met Leu Ala Ala Ser Lys 
    930                 935                 940                 


Asn Leu Gln Thr Ser Ala Ser 
945                 950     


<210>  287
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  287
atggtgctgt ctcctgccga caagaccaac gtcaaggccg cctggggtaa ggtcggcgcg       60

cacgctggcg agtatggtgc ggaggccctg gagaggatgt tcctgtcctt ccccaccacc      120

aagacctact tcccgcactt cgacctgagc cacggctctg cccaggttaa gggccacggc      180

aagaaggtgg ccgacgcgct gaccaacgcc gtggcgcacg tggacgacat gcccaacgcg      240

ctgtccgccc tgagcgacct gcacgcgcac aagcttcggg tggacccggt caacttcaag      300

ctcctaagcc actgcctgct ggtgaccctg gccgcccacc tccccgccga gttcacccct      360

gcggtgcacg cctccctgga caagttcctg gcttctgtga gcaccgtgct gacctccaaa      420

taccgttaa                                                              429


<210>  288
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  289
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  289
atggcggcgg ccaccggacc ctcgttttgg ctggggaatg aaaccctgaa ggtgccgctg       60

gcgctctttg ccttgaaccg gcagcgcctg tgtgagcggc tgcggaagaa ccctgctgtg      120

caggccggct ccatcgtggt cctgcagggc ggggaggaga ctcagcgcta ctgcaccgac      180

accggggtcc tcttccgcca ggagtccttc tttcactggg cgttcggtgt cactgagcca      240

ggctgctatg gtgtcatcga tgttgacact gggaagtcga ccctgtttgt gcccaggctt      300

cctgccagcc atgccacctg gatgggaaag atccattcca aggagcactt caaggagaag      360

tatgccgtgg acgacgtcca gtacgtagat gagattgcca gcgtcctgac gtcacagaag      420

ccctctgtcc tcctcacttt gcgtggcgtc aacacggaca gcggcagtgt ctgcagggag      480

gcctcctttg acggcatcag caagttcgaa gtcaacaata ccattcttca cccagagatc      540

gttgagtgcc gagtgtttaa gacggatatg gagctggagg ttctgcgcta taccaataaa      600

atctccagcg aggcccaccg tgaggtaatg aaggctgtaa aagtgggaat gaaagaatat      660

gagttggaaa gcctcttcga gcactactgc tactcccggg gcggcatgcg ccacagctcc      720

tacacctgca tctgcggcag tggtgagaac tcagccgtgc tacactacgg acacgccgga      780

gctcccaacg accgaacgat ccagaatggg gatatgtgcc tgttcgacat gggcggtgag      840

tattactgct tcgcttccga catcacctgc tcctttcccg ccaacggcaa gttcactgca      900

gaccagaagg ccgtctatga ggcagtgctg cggagctccc gtgccgtcat gggtgccatg      960

aagccaggtg tctggtggcc tgacatgcac cgcctggctg accgcatcca cctggaggag     1020

ctggcccaca tgggcatcct gagcggcagc gtggacgcca tggtccaggc tcacctgggg     1080

gccgtgttta tgcctcacgg gcttggccac ttcctgggca ttgacgtgca cgacgtggga     1140

ggctacccag agggcgtgga gcgcatcgac gagcccggcc tgcggagcct gcgcactgca     1200

cggcacctgc agccaggcat ggtgctcacc gtggagccgg gcatctactt catcgaccac     1260

ctcctggatg aggccctggc ggacccggcc cgcgcctcct tccttaaccg cgaggtcctg     1320

cagcgctttc gcggttttgg cggggtccgc atcgaggagg acgtcgtggt gactgacagc     1380

ggcatagagc tgctgacctg cgtgccccgc actgtggaag agattgaagc atgcatggca     1440

ggctgtgaca aggcctttac ccccttctct ggccccaagt ag                        1482


<210>  290
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Ala Ala Ala Thr Gly Pro Ser Phe Trp Leu Gly Asn Glu Thr Leu 
1               5                   10                  15      


Lys Val Pro Leu Ala Leu Phe Ala Leu Asn Arg Gln Arg Leu Cys Glu 
            20                  25                  30          


Arg Leu Arg Lys Asn Pro Ala Val Gln Ala Gly Ser Ile Val Val Leu 
        35                  40                  45              


Gln Gly Gly Glu Glu Thr Gln Arg Tyr Cys Thr Asp Thr Gly Val Leu 
    50                  55                  60                  


Phe Arg Gln Glu Ser Phe Phe His Trp Ala Phe Gly Val Thr Glu Pro 
65                  70                  75                  80  


Gly Cys Tyr Gly Val Ile Asp Val Asp Thr Gly Lys Ser Thr Leu Phe 
                85                  90                  95      


Val Pro Arg Leu Pro Ala Ser His Ala Thr Trp Met Gly Lys Ile His 
            100                 105                 110         


Ser Lys Glu His Phe Lys Glu Lys Tyr Ala Val Asp Asp Val Gln Tyr 
        115                 120                 125             


Val Asp Glu Ile Ala Ser Val Leu Thr Ser Gln Lys Pro Ser Val Leu 
    130                 135                 140                 


Leu Thr Leu Arg Gly Val Asn Thr Asp Ser Gly Ser Val Cys Arg Glu 
145                 150                 155                 160 


Ala Ser Phe Asp Gly Ile Ser Lys Phe Glu Val Asn Asn Thr Ile Leu 
                165                 170                 175     


His Pro Glu Ile Val Glu Cys Arg Val Phe Lys Thr Asp Met Glu Leu 
            180                 185                 190         


Glu Val Leu Arg Tyr Thr Asn Lys Ile Ser Ser Glu Ala His Arg Glu 
        195                 200                 205             


Val Met Lys Ala Val Lys Val Gly Met Lys Glu Tyr Glu Leu Glu Ser 
    210                 215                 220                 


Leu Phe Glu His Tyr Cys Tyr Ser Arg Gly Gly Met Arg His Ser Ser 
225                 230                 235                 240 


Tyr Thr Cys Ile Cys Gly Ser Gly Glu Asn Ser Ala Val Leu His Tyr 
                245                 250                 255     


Gly His Ala Gly Ala Pro Asn Asp Arg Thr Ile Gln Asn Gly Asp Met 
            260                 265                 270         


Cys Leu Phe Asp Met Gly Gly Glu Tyr Tyr Cys Phe Ala Ser Asp Ile 
        275                 280                 285             


Thr Cys Ser Phe Pro Ala Asn Gly Lys Phe Thr Ala Asp Gln Lys Ala 
    290                 295                 300                 


Val Tyr Glu Ala Val Leu Arg Ser Ser Arg Ala Val Met Gly Ala Met 
305                 310                 315                 320 


Lys Pro Gly Val Trp Trp Pro Asp Met His Arg Leu Ala Asp Arg Ile 
                325                 330                 335     


His Leu Glu Glu Leu Ala His Met Gly Ile Leu Ser Gly Ser Val Asp 
            340                 345                 350         


Ala Met Val Gln Ala His Leu Gly Ala Val Phe Met Pro His Gly Leu 
        355                 360                 365             


Gly His Phe Leu Gly Ile Asp Val His Asp Val Gly Gly Tyr Pro Glu 
    370                 375                 380                 


Gly Val Glu Arg Ile Asp Glu Pro Gly Leu Arg Ser Leu Arg Thr Ala 
385                 390                 395                 400 


Arg His Leu Gln Pro Gly Met Val Leu Thr Val Glu Pro Gly Ile Tyr 
                405                 410                 415     


Phe Ile Asp His Leu Leu Asp Glu Ala Leu Ala Asp Pro Ala Arg Ala 
            420                 425                 430         


Ser Phe Leu Asn Arg Glu Val Leu Gln Arg Phe Arg Gly Phe Gly Gly 
        435                 440                 445             


Val Arg Ile Glu Glu Asp Val Val Val Thr Asp Ser Gly Ile Glu Leu 
    450                 455                 460                 


Leu Thr Cys Val Pro Arg Thr Val Glu Glu Ile Glu Ala Cys Met Ala 
465                 470                 475                 480 


Gly Cys Asp Lys Ala Phe Thr Pro Phe Ser Gly Pro Lys 
                485                 490             


<210>  291
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  291
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ctaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcacgtacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  292
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  293
<211>  3753
<212>  DNA
<213>  Homo sapiens

<400>  293
atggagcagc tatcagatga agaaattgat catggtgctg aagaagacag tgacaaggaa       60

gatcaggacc tggacaaaat gtttggagcc tggcttggag aactagacaa actcactcag      120

agtttggatt ctgacaagcc catggaacca gtaaaaagat ctcctcttcg ccaggaaaca      180

aacatggcca acttttctta ccgcttctcc atatacaact tgaatgaagc tctgaatcag      240

ggagagactg tggatctgga tgccttgatg gctgatcttt gctctataga gcaggagctc      300

agcagcattg gttcaggaaa cagtaagcgt caaatcacag aaacgaaagc tactcagaaa      360

ttgcctgtta gccgacatac attgaaacat ggcaccttga aaggattatc ttcttcatct      420

aataggatag ctaaaccttc ccatgccagc tactccttgg acgacgtcac tgcacagtta      480

gaacaggcct ctttgagtat ggatgaggct gctcagcaat ctgtactaga agatactaaa      540

cccttagtaa ctaatcagca cagaagaacc gcgtcagcag gcacagtgag tgatgctgaa      600

gtacactcta ttagtaattc ctcccattcc agcatcactt ccgcagcctc cagcatggac      660

tctttggata ttgataaagt aacacgccct caagagctgg atttgacaca tcaagggcag      720

ccaattactg aggaagaaca ggcagcaaaa ttgaaagctg agaagatcag agttgcccta      780

gagaaaatta aagaggcaca agtgaaaaag ctggtgatca gagtccacat gtctgatgac      840

agttctaaaa caatgatggt ggatgagagg cagacagtaa gacaagtact ggataacctg      900

atggacaaat cccactgcgg ttatagttta gactggtcac tggtagaaac cgtttctgaa      960

ttacaaatgg agagaatctt tgaagaccat gaaaacttgg ttgaaaatct tcttaattgg     1020

acaagagata gccaaaacaa gcttatattt atggagcgta tagaaaaata tgcacttttc     1080

aaaaacccac agaattatct tttggggaaa aaagaaacag ctgagatggc agatagaaac     1140

aaagaagtcc tcttggagga atgtttttgt ggaagttctg taactgtacc agaaattgaa     1200

ggagtccttt ggttgaagga tgatggcaag aagtcctgga aaaagcgtta ttttctcttg     1260

cgagcatctg gtatctacta tgttcccaaa ggaaaagcaa aggtctctcg ggatctggtg     1320

tgctttctcc agctggatca tgtcaacgtt tattatggcc aggactatcg gaacaaatac     1380

aaagcaccta cagactattg tctggtgctg aagcatccac aaatccagaa gaaatctcaa     1440

tatatcaaat acctttgttg tgatgatgtg aggacactgc atcagtgggt caatgggatc     1500

cgcattgcaa agtatgggaa gcagctctat atgaactacc aagaagcctt gaagaggaca     1560

gagtcagcct atgattggac ttccttatcc agctccagca ttaaatcggg atccagttct     1620

tccagcatcc cagagtctca gtcaaaccac tccaatcagt ctgatagcgg agtttctgac     1680

acccagccag caggacacgt ccgttcccag agcattgtga gctccgtatt ctctgaagcc     1740

tggaaacgag gcactcagtt ggaagagtcc agcaaggcca gaatggagtc tatgaatcgg     1800

ccctacactt cacttgtgcc ccctttatcc ccgcaaccta agatagtcac cccctacact     1860

gcttcacagc cttcaccacc tctacctcct ccgccacccc cacctcctcc tccaccaccc     1920

cctccaccac cccctcctcc cccactcccc agccagtctg caccttctgc aggctcagca     1980

gccccaatgt tcgtcaagta cagcacaata acacggctac agaatgcgtc tcagcattca     2040

ggggccctgt ttaagccgcc aacaccccca gtgatgcagt cacagtcagt gaagcctcag     2100

atcctggtac cccccaatgg agttgttcca ccaccccctc cccctcctcc acccccaacc     2160

ccaggctctg ccatggccca gctaaagcct gcaccgtgtg ccccatccct tccacagttc     2220

agtgccccgc ctcctccact gaagatccat caagttcagc atattactca ggtggctccc     2280

ccaacacccc ccccacctcc tcctatccct gcacccctcc ctccccaagc tcccccaaaa     2340

ccccttgtga ccatccccgc accaaccagc accaagactg tggcacctgt tgtgactcaa     2400

gctgcaccac ccacacctac tcctccagtg cccccagcaa aaaagcagcc agctttccct     2460

gcttcttaca ttccaccctc tccccctacc cctcctgttc cagtaccccc gccaacatta     2520

cccaagcaac agagcttctg tgcaaaaccc cctccctctc cactgtcacc ggtgccctcg     2580

gtcgtgaagc agatagccag ccagtttcca ccccctccaa ctccccctgc catggaatct     2640

cagcccttaa agcctgtccc agcaaatgta gctccacagt cccctcctgc agtaaaagca     2700

aagcccaagt ggcagcccag ctccatccca gtcccttctc cggacttccc tcctccccct     2760

cctgaaagca gcctggtgtt tcctcctcca cccccatcac ctgtcccagc cccaccacca     2820

ccacctccac ccacagcttc tcctacccct gacaaaagtg gatctccagg caaaaagacc     2880

agtaagacgt ccagccctgg gggaaagaaa ccacccccaa ccccacagcg caactccagc     2940

attaaatcca gcagtggtgc agagcacccc gagcccaaga gaccctcggt ggacagtcta     3000

gtcagcaagt ttacaccgcc agcagaatca gggtctccca gcaaggagac cctaccacct     3060

cctgcagcac cccccaagcc tggaaaactc aatctttctg gagtcaacct tcctggagtt     3120

ctccaacaag ggtgtgtgtc agcaaaagcc cctgttctga gtgggcgtgg aaaggactcc     3180

gtggtggaat ttccttctcc tccatccgat tctgattttc caccccctcc acctgaaaca     3240

gagcttcctc tgccccccat tgagattcca gcagttttct cgggaaacac ctctccaaaa     3300

gtggcagtcg ttaatcctca accacaacaa tggtctaaaa tgtcagtgaa gaaggcccct     3360

ccacccacac gacccaaacg gaatgatagc acccgcctca ctcaagctga gatttctgag     3420

cagccaacaa tggccacagt tgtgccacaa gtgcccacct ctcccaaatc cagccttagt     3480

gtccagcctg gattcctggc tgacctcaac aggacactgc aacgaaagtc catcactcgg     3540

cacggctcac tctcctcccg catgtccaga gcagaaccaa cagccaccat ggatgatatg     3600

gcattgcctc caccaccccc tgaactgctg tctgatcaac agaaggctgg ttacggaggc     3660

agtcatatat caggctatgc aacgttgcgg agaggacccc ctcctgctcc ccccaaaaga     3720

gaccagaaca ccaagctctc cagagactgg tag                                  3753


<210>  294
<211>  1250
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Glu Gln Leu Ser Asp Glu Glu Ile Asp His Gly Ala Glu Glu Asp 
1               5                   10                  15      


Ser Asp Lys Glu Asp Gln Asp Leu Asp Lys Met Phe Gly Ala Trp Leu 
            20                  25                  30          


Gly Glu Leu Asp Lys Leu Thr Gln Ser Leu Asp Ser Asp Lys Pro Met 
        35                  40                  45              


Glu Pro Val Lys Arg Ser Pro Leu Arg Gln Glu Thr Asn Met Ala Asn 
    50                  55                  60                  


Phe Ser Tyr Arg Phe Ser Ile Tyr Asn Leu Asn Glu Ala Leu Asn Gln 
65                  70                  75                  80  


Gly Glu Thr Val Asp Leu Asp Ala Leu Met Ala Asp Leu Cys Ser Ile 
                85                  90                  95      


Glu Gln Glu Leu Ser Ser Ile Gly Ser Gly Asn Ser Lys Arg Gln Ile 
            100                 105                 110         


Thr Glu Thr Lys Ala Thr Gln Lys Leu Pro Val Ser Arg His Thr Leu 
        115                 120                 125             


Lys His Gly Thr Leu Lys Gly Leu Ser Ser Ser Ser Asn Arg Ile Ala 
    130                 135                 140                 


Lys Pro Ser His Ala Ser Tyr Ser Leu Asp Asp Val Thr Ala Gln Leu 
145                 150                 155                 160 


Glu Gln Ala Ser Leu Ser Met Asp Glu Ala Ala Gln Gln Ser Val Leu 
                165                 170                 175     


Glu Asp Thr Lys Pro Leu Val Thr Asn Gln His Arg Arg Thr Ala Ser 
            180                 185                 190         


Ala Gly Thr Val Ser Asp Ala Glu Val His Ser Ile Ser Asn Ser Ser 
        195                 200                 205             


His Ser Ser Ile Thr Ser Ala Ala Ser Ser Met Asp Ser Leu Asp Ile 
    210                 215                 220                 


Asp Lys Val Thr Arg Pro Gln Glu Leu Asp Leu Thr His Gln Gly Gln 
225                 230                 235                 240 


Pro Ile Thr Glu Glu Glu Gln Ala Ala Lys Leu Lys Ala Glu Lys Ile 
                245                 250                 255     


Arg Val Ala Leu Glu Lys Ile Lys Glu Ala Gln Val Lys Lys Leu Val 
            260                 265                 270         


Ile Arg Val His Met Ser Asp Asp Ser Ser Lys Thr Met Met Val Asp 
        275                 280                 285             


Glu Arg Gln Thr Val Arg Gln Val Leu Asp Asn Leu Met Asp Lys Ser 
    290                 295                 300                 


His Cys Gly Tyr Ser Leu Asp Trp Ser Leu Val Glu Thr Val Ser Glu 
305                 310                 315                 320 


Leu Gln Met Glu Arg Ile Phe Glu Asp His Glu Asn Leu Val Glu Asn 
                325                 330                 335     


Leu Leu Asn Trp Thr Arg Asp Ser Gln Asn Lys Leu Ile Phe Met Glu 
            340                 345                 350         


Arg Ile Glu Lys Tyr Ala Leu Phe Lys Asn Pro Gln Asn Tyr Leu Leu 
        355                 360                 365             


Gly Lys Lys Glu Thr Ala Glu Met Ala Asp Arg Asn Lys Glu Val Leu 
    370                 375                 380                 


Leu Glu Glu Cys Phe Cys Gly Ser Ser Val Thr Val Pro Glu Ile Glu 
385                 390                 395                 400 


Gly Val Leu Trp Leu Lys Asp Asp Gly Lys Lys Ser Trp Lys Lys Arg 
                405                 410                 415     


Tyr Phe Leu Leu Arg Ala Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys 
            420                 425                 430         


Ala Lys Val Ser Arg Asp Leu Val Cys Phe Leu Gln Leu Asp His Val 
        435                 440                 445             


Asn Val Tyr Tyr Gly Gln Asp Tyr Arg Asn Lys Tyr Lys Ala Pro Thr 
    450                 455                 460                 


Asp Tyr Cys Leu Val Leu Lys His Pro Gln Ile Gln Lys Lys Ser Gln 
465                 470                 475                 480 


Tyr Ile Lys Tyr Leu Cys Cys Asp Asp Val Arg Thr Leu His Gln Trp 
                485                 490                 495     


Val Asn Gly Ile Arg Ile Ala Lys Tyr Gly Lys Gln Leu Tyr Met Asn 
            500                 505                 510         


Tyr Gln Glu Ala Leu Lys Arg Thr Glu Ser Ala Tyr Asp Trp Thr Ser 
        515                 520                 525             


Leu Ser Ser Ser Ser Ile Lys Ser Gly Ser Ser Ser Ser Ser Ile Pro 
    530                 535                 540                 


Glu Ser Gln Ser Asn His Ser Asn Gln Ser Asp Ser Gly Val Ser Asp 
545                 550                 555                 560 


Thr Gln Pro Ala Gly His Val Arg Ser Gln Ser Ile Val Ser Ser Val 
                565                 570                 575     


Phe Ser Glu Ala Trp Lys Arg Gly Thr Gln Leu Glu Glu Ser Ser Lys 
            580                 585                 590         


Ala Arg Met Glu Ser Met Asn Arg Pro Tyr Thr Ser Leu Val Pro Pro 
        595                 600                 605             


Leu Ser Pro Gln Pro Lys Ile Val Thr Pro Tyr Thr Ala Ser Gln Pro 
    610                 615                 620                 


Ser Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
625                 630                 635                 640 


Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Gln Ser Ala Pro Ser 
                645                 650                 655     


Ala Gly Ser Ala Ala Pro Met Phe Val Lys Tyr Ser Thr Ile Thr Arg 
            660                 665                 670         


Leu Gln Asn Ala Ser Gln His Ser Gly Ala Leu Phe Lys Pro Pro Thr 
        675                 680                 685             


Pro Pro Val Met Gln Ser Gln Ser Val Lys Pro Gln Ile Leu Val Pro 
    690                 695                 700                 


Pro Asn Gly Val Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Thr 
705                 710                 715                 720 


Pro Gly Ser Ala Met Ala Gln Leu Lys Pro Ala Pro Cys Ala Pro Ser 
                725                 730                 735     


Leu Pro Gln Phe Ser Ala Pro Pro Pro Pro Leu Lys Ile His Gln Val 
            740                 745                 750         


Gln His Ile Thr Gln Val Ala Pro Pro Thr Pro Pro Pro Pro Pro Pro 
        755                 760                 765             


Ile Pro Ala Pro Leu Pro Pro Gln Ala Pro Pro Lys Pro Leu Val Thr 
    770                 775                 780                 


Ile Pro Ala Pro Thr Ser Thr Lys Thr Val Ala Pro Val Val Thr Gln 
785                 790                 795                 800 


Ala Ala Pro Pro Thr Pro Thr Pro Pro Val Pro Pro Ala Lys Lys Gln 
                805                 810                 815     


Pro Ala Phe Pro Ala Ser Tyr Ile Pro Pro Ser Pro Pro Thr Pro Pro 
            820                 825                 830         


Val Pro Val Pro Pro Pro Thr Leu Pro Lys Gln Gln Ser Phe Cys Ala 
        835                 840                 845             


Lys Pro Pro Pro Ser Pro Leu Ser Pro Val Pro Ser Val Val Lys Gln 
    850                 855                 860                 


Ile Ala Ser Gln Phe Pro Pro Pro Pro Thr Pro Pro Ala Met Glu Ser 
865                 870                 875                 880 


Gln Pro Leu Lys Pro Val Pro Ala Asn Val Ala Pro Gln Ser Pro Pro 
                885                 890                 895     


Ala Val Lys Ala Lys Pro Lys Trp Gln Pro Ser Ser Ile Pro Val Pro 
            900                 905                 910         


Ser Pro Asp Phe Pro Pro Pro Pro Pro Glu Ser Ser Leu Val Phe Pro 
        915                 920                 925             


Pro Pro Pro Pro Ser Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Thr Ala Ser Pro Thr Pro Asp Lys Ser Gly Ser Pro Gly Lys Lys Thr 
945                 950                 955                 960 


Ser Lys Thr Ser Ser Pro Gly Gly Lys Lys Pro Pro Pro Thr Pro Gln 
                965                 970                 975     


Arg Asn Ser Ser Ile Lys Ser Ser Ser Gly Ala Glu His Pro Glu Pro 
            980                 985                 990         


Lys Arg Pro Ser Val Asp Ser Leu  Val Ser Lys Phe Thr  Pro Pro Ala 
        995                 1000                 1005             


Glu Ser  Gly Ser Pro Ser Lys  Glu Thr Leu Pro Pro  Pro Ala Ala 
    1010                 1015                 1020             


Pro Pro  Lys Pro Gly Lys Leu  Asn Leu Ser Gly Val  Asn Leu Pro 
    1025                 1030                 1035             


Gly Val  Leu Gln Gln Gly Cys  Val Ser Ala Lys Ala  Pro Val Leu 
    1040                 1045                 1050             


Ser Gly  Arg Gly Lys Asp Ser  Val Val Glu Phe Pro  Ser Pro Pro 
    1055                 1060                 1065             


Ser Asp  Ser Asp Phe Pro Pro  Pro Pro Pro Glu Thr  Glu Leu Pro 
    1070                 1075                 1080             


Leu Pro  Pro Ile Glu Ile Pro  Ala Val Phe Ser Gly  Asn Thr Ser 
    1085                 1090                 1095             


Pro Lys  Val Ala Val Val Asn  Pro Gln Pro Gln Gln  Trp Ser Lys 
    1100                 1105                 1110             


Met Ser  Val Lys Lys Ala Pro  Pro Pro Thr Arg Pro  Lys Arg Asn 
    1115                 1120                 1125             


Asp Ser  Thr Arg Leu Thr Gln  Ala Glu Ile Ser Glu  Gln Pro Thr 
    1130                 1135                 1140             


Met Ala  Thr Val Val Pro Gln  Val Pro Thr Ser Pro  Lys Ser Ser 
    1145                 1150                 1155             


Leu Ser  Val Gln Pro Gly Phe  Leu Ala Asp Leu Asn  Arg Thr Leu 
    1160                 1165                 1170             


Gln Arg  Lys Ser Ile Thr Arg  His Gly Ser Leu Ser  Ser Arg Met 
    1175                 1180                 1185             


Ser Arg  Ala Glu Pro Thr Ala  Thr Met Asp Asp Met  Ala Leu Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro Glu Leu Leu  Ser Asp Gln Gln Lys  Ala Gly Tyr 
    1205                 1210                 1215             


Gly Gly  Ser His Ile Ser Gly  Tyr Ala Thr Leu Arg  Arg Gly Pro 
    1220                 1225                 1230             


Pro Pro  Ala Pro Pro Lys Arg  Asp Gln Asn Thr Lys  Leu Ser Arg 
    1235                 1240                 1245             


Asp Trp  
    1250 


<210>  295
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  295
ggaaaacaac cagctgtcac agggactaac tgagggagaa ctcactcatc acctgggaga       60

tggtgctagg ccattcatga ggggtccagc cccatgatct aatcacctcc caccaggccc      120

acctccaaca ctgggaatca catctcaaca tgaaatttgg agagacacac atccaaacta      180

ttgcaccaca ggaagctgga agaggtggac ggtcctcccc tggagcactc agagacagcc      240

accaacacct tgatctcaga ttcctgactc ccagaactct gaaaaaattt ttgttgtttt      300

aagccacatt tgtgatattt tgttacggca gccacagcac ggatatagct ggtaacagag      360

ttctttagcc tccaaaatac aagcctgggg taaataacta ttgaatttgg ccacatggaa      420

atcaggaaga atgtaataag catcatcgat ggacgggatg acctgggaga tcgtggcaag      480

tttaaagcta attggaagtt ggcaaccaaa aaatcctgtc ttgcaaattg ccaggaaatt      540

gccaagaaaa cttttagaaa acatggttaa agatggagaa acctggatga atccctggtt      600

tctgaagagg tgcttaggca ttgaagtgag actgatgaga cttcacactg taccttcaga      660

agggcagaca ctcacgagat catcaaccgc ggctccctcg ctgggaggca gacacagagc      720

tggaggcggc ggccacaaac taggtgggca gagaggcgtc agcatcggga cttgcgggag      780

gccctgggaa ggaacaggca gcggtggggc ctggacagcc ctggggaaag gaagttactt      840

ggaggagacc aggggcttgc atttgggcca aaaccaagga caagagatca gctggtccca      900

gggaactctg gagcccagca ccccaccacg ggtgcagggt cctgacaacc cgagagggct      960

gtgggcaccg ggcaccagcc tgtggggatt ctgaaggctg ctgcccagcc acacgtcccg     1020

gttctgaaca aagggttcaa gagacacctg caaacctacc tttctgagag cagcctctta     1080

gcctcagctg gtattggcct ttggtcaccc cacatgcccc gacagtgggg cctggcctca     1140

gaaaggggcc cctccatttg tactttctat ctgatccttg acacagtgct aacaccaaag     1200

accaaacccg aatcttggtt cacatactct gcaaagaaat gactaagact agttcttccg     1260

gaggtcagtt ttagaacgtt tattctgact taattctgcc ttatctctgt gcaccaagaa     1320

aactatctgc acatctgtag taaaatgtga aggtaccttc attttgtttg tatactaaac     1380

ttttaagaaa tacctcactt tttaaaactt ggttttgtgt tttgtatgct tataatattt     1440

tccataatag atcattttaa tgatgaactc tgagtcttct gacagaatgc agatcaatgg     1500

attcctagcc atcggggagg cgttgattgc aaaggggcct ggtggaattt ttggagagat     1560

tctacatctt cttgcaactg ttcatctgga ttacggtggt ggttgcatga ctgtgcattt     1620

gttgaaactt acatgtcaca ggatggatta tactgaatgt aaactacact tgagtaaata     1680

tgacttttaa aacttt                                                     1696


<210>  296
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Asp Gly Met Thr Trp Glu Ile Val Ala Ser Leu Lys Leu Ile Gly 
1               5                   10                  15      


Ser Trp Gln Pro Lys Asn Pro Val Leu Gln Ile Ala Arg Lys Leu Pro 
            20                  25                  30          


Arg Lys Leu Leu Glu Asn Met Val Lys Asp Gly Glu Thr Trp Met Asn 
        35                  40                  45              


Pro Trp Phe Leu Lys Arg Cys Leu Gly Ile Glu Val Arg Leu Met Arg 
    50                  55                  60                  


Leu His Thr Val Pro Ser Glu Gly Gln Thr Leu Thr Arg Ser Ser Thr 
65                  70                  75                  80  


Ala Ala Pro Ser Leu Gly Gly Arg His Arg Ala Gly Gly Gly Gly His 
                85                  90                  95      


Lys Leu Gly Gly Gln Arg Gly Val Ser Ile Gly Thr Cys Gly Arg Pro 
            100                 105                 110         


Trp Glu Gly Thr Gly Ser Gly Gly Ala Trp Thr Ala Leu Gly Lys Gly 
        115                 120                 125             


Ser Tyr Leu Glu Glu Thr Arg Gly Leu His Leu Gly Gln Asn Gln Gly 
    130                 135                 140                 


Gln Glu Ile Ser Trp Ser Gln Gly Thr Leu Glu Pro Ser Thr Pro Pro 
145                 150                 155                 160 


Arg Val Gln Gly Pro Asp Asn Pro Arg Gly Leu Trp Ala Pro Gly Thr 
                165                 170                 175     


Ser Leu Trp Gly Phe 
            180     


<210>  297
<211>  3744
<212>  DNA
<213>  Homo sapiens

<400>  297
atgcagagtt cagctttagt agaaagtcta attacagtaa aaatggcagc tgagaatagt       60

gaggaaggca atacctgtat tattcctcaa agaaatttgt tcaaagcttt atcagaagag      120

gcttggaact cagggtttat ggggaactca tctagaactg ctgacaaaga gaatacttta      180

cagtgtccaa aaacaccttt gcgccaggat ttagaggcaa atgaacaaga tgcaaggcca      240

aagcaagaga accatcttca ctctctggga agaaataagg tgggttacca tttacatccc      300

agtgataagg gccagtttga tcattccaaa gatggttggt taggccccgg ccctatgcca      360

gctgtacaca aagcggcaaa tggacactca agaaccaaga tgatatcaac ctccatcaag      420

acagctcgga aaagtaaaag ggcatcaggg ctgaggataa atgattatga taaccagtgt      480

gatgttgttt atatcagtca accaataaca gaatgccact ttgagaatca aaaatcaata      540

ttatcttctc ggaaaacagc cagaaagagt actcgaggat actttttcaa tggtgactgt      600

tgtgagctgc caactgttcg tacactggcc agaaatttac actcccagga aaaagcaagc      660

tgctcagcat tggcatcaga ggcagttttc actcctaagc agacccttac aattccagcc      720

cctagacata cagtagatgt gcagcttccc agagaagaca accctgaaga acctagcaag      780

gaaatcacct ctcacgagga aggaggtgga gacgtttcac ctcgaaaaga acctcaagag      840

cctgaggttt gccccacaaa gattaagccg aacctgagca gctcccctag gtcagaggaa      900

acgacagcct ccagcctggt gtggcctctc cctgctcacc ttcctgaaga ggacctgcca      960

gaaggtggct ccacagtctc agctcccaca gcaagtggga tgtcttctcc tgaacacaac     1020

caaccaccag ttgcactgtt ggatacggag gagatgagtg taccccagga ctgtcacctc     1080

cttccctcca ctgaaagctt ttccggggga gtcagtgaag atgtcatttc taggcctcat     1140

tctcctcctg aaatagtcag tagagaagaa agtcctcagt gctcagaaaa tcagagttcc     1200

ccaatgggct tggagccccc catgagtctg ggaaaggctg aggacaacca aagcatcagt     1260

gctgaggttg agtctggaga cacccaggag ctaaatgtcg acccactctt gaaggaaagc     1320

agcactttta ctgatgaaaa ccccagtgaa actgaggaaa gtgaggcagc aggtggtata     1380

ggaaaattag agggagagga cggtgatgta aaatgcctgt cagaaaaaga cacgtatgat     1440

acaagcattg actcactcga agagaatttg gacaagaaga aaaaaggtaa aaaattccct     1500

gaggcctctg ataggtgcct aagaagtcaa ctttcggatt cttcctctgc tgacagatgc     1560

ctaagaaatc agagttcaga ttcttcctca gcttgtcttg aaatcaaagt tcctaaaaat     1620

cctagtgcaa aacgttcaaa aaaagaaggg caccctggtg ggacaacacc taagggcctt     1680

ctacctgaca gtttccacac ggaaactctg gaggacacag aaaagccaag tgtcaatgaa     1740

cgcccctctg agaaagatgc tgagcaggag ggcgaaggcg gggggatcat caccaggcag     1800

actttgaaaa acatgctgga caaagaagtc aaggagttac gaggagagat tttccccagc     1860

agggacccca taaccacagc tggacagcca ctgcctggag agagattgga aatctatgtt     1920

cagtctaaaa tggatgagaa gaatgctcat atcccctcag aaagtattgc ttgtaagagg     1980

gacccagaac aggcaaaaga agagccaggg catattccca cacagcatgt ggaggaggct     2040

gtgaatgagg tagacaacga aaacacccag cagaaagatg atgagagtga tgccccatgc     2100

agctctcttg ggttgtcgag tagtggaagt ggtgatgctg ctagggcacc aaaatcggtg     2160

ccaaggccta aaagattgac ctcttcaacc tacaacctaa gacacgctca ttctctgggc     2220

tccttggatg cttcaaaagt gacttcagaa aaggaagctg cacaagtaaa ccccataatg     2280

ccaaaggaaa atggagcttc agagagtgga gaccccctag atgaggacga tgttgacacc     2340

gtggtagatg aacagccaaa gtttatggaa tggtgtgctg aggaggagaa ccaagagctc     2400

atcgccaact tcaatgccca gtacatgaaa gttcagaagg gctggatcca gttggagaaa     2460

gaaggacagc caacaccaag agcaaggaac aaatcagata aactgaaaga gatttggaaa     2520

agcaagaaaa ggtcacggaa atgtaggagt tcattggaga gtcagaagtg ttctcctgtt     2580

cagatgctct ttatgacaaa ctttaaatta tctaatgttt gtaaatggtt cttagagaca     2640

actgaaaccc ggtctctagt cattgtgaag aagctcaata ctcgccttcc aggagacgtt     2700

ccccctgtca agcatcctct tcagaaatac gctccttcca gcctatatcc cagttcacta     2760

caggctgagc gcttgaaaaa gcacttgaag aaatttcctg gagctacccc tgctaagaat     2820

aattggaaaa tgcagaagct ctgggccaaa tttcgagaga atcctgatca agtggagcca     2880

gaagatggca gtgatgtcag ccccggccct aattctgaag acagcataga ggaagtcaag     2940

gaagatagaa acagtcatcc tccagcaaac ctgcccactc cagccagtac ccggattctt     3000

agaaaatatt ccaatattcg aggaaagctc agagcccagc aacgtttaat caagaatgag     3060

aaaatggaat gcccagatgc tctggctgtg gaaagtaagc caagtcgtaa gagcgtatgc     3120

atcaaccctc tgatgtcccc caagcttgcc ctgcaagtgg atgcagatgg gtttcctgtt     3180

aagcccaaga gtactgaagg aatgaaggga aggaagggga agcaggtgtc tgaaatcttg     3240

cctaaagcag aagttcagag taaacgcaag agaacagaag gcagcagccc tccagatagt     3300

aagaacaagg ggcctacggt gaaagccagc aaagaaaagc atgctgatgg agccaccaaa     3360

acccctgctg ccaagaggcc agctgcaagg gacagaagca gccaaccccc caaaaagacg     3420

tctttgaaag agaataaagt gaagatccct aaaaagtccg ctgggaagag ctgccctccc     3480

tccaggaaag aaaaagagaa tacaaacaaa aggccttccc agtctattgc ctcggaaaca     3540

ctgacgaaac ctgcaaaaca gaagggggcc ggtgaatcct cttcaaggcc tcagaaagcc     3600

acgaatagga agcagagtag tggaaagact cgggccagac cctcaacgaa aaccccagag     3660

agcagtgcag ctcagagaaa gcgaaagctg aaggcaaagc tggactgttc gcacagcaaa     3720

cggaggcggc tggatgcaaa gtga                                            3744


<210>  298
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Gln Ser Ser Ala Leu Val Glu Ser Leu Ile Thr Val Lys Met Ala 
1               5                   10                  15      


Ala Glu Asn Ser Glu Glu Gly Asn Thr Cys Ile Ile Pro Gln Arg Asn 
            20                  25                  30          


Leu Phe Lys Ala Leu Ser Glu Glu Ala Trp Asn Ser Gly Phe Met Gly 
        35                  40                  45              


Asn Ser Ser Arg Thr Ala Asp Lys Glu Asn Thr Leu Gln Cys Pro Lys 
    50                  55                  60                  


Thr Pro Leu Arg Gln Asp Leu Glu Ala Asn Glu Gln Asp Ala Arg Pro 
65                  70                  75                  80  


Lys Gln Glu Asn His Leu His Ser Leu Gly Arg Asn Lys Val Gly Tyr 
                85                  90                  95      


His Leu His Pro Ser Asp Lys Gly Gln Phe Asp His Ser Lys Asp Gly 
            100                 105                 110         


Trp Leu Gly Pro Gly Pro Met Pro Ala Val His Lys Ala Ala Asn Gly 
        115                 120                 125             


His Ser Arg Thr Lys Met Ile Ser Thr Ser Ile Lys Thr Ala Arg Lys 
    130                 135                 140                 


Ser Lys Arg Ala Ser Gly Leu Arg Ile Asn Asp Tyr Asp Asn Gln Cys 
145                 150                 155                 160 


Asp Val Val Tyr Ile Ser Gln Pro Ile Thr Glu Cys His Phe Glu Asn 
                165                 170                 175     


Gln Lys Ser Ile Leu Ser Ser Arg Lys Thr Ala Arg Lys Ser Thr Arg 
            180                 185                 190         


Gly Tyr Phe Phe Asn Gly Asp Cys Cys Glu Leu Pro Thr Val Arg Thr 
        195                 200                 205             


Leu Ala Arg Asn Leu His Ser Gln Glu Lys Ala Ser Cys Ser Ala Leu 
    210                 215                 220                 


Ala Ser Glu Ala Val Phe Thr Pro Lys Gln Thr Leu Thr Ile Pro Ala 
225                 230                 235                 240 


Pro Arg His Thr Val Asp Val Gln Leu Pro Arg Glu Asp Asn Pro Glu 
                245                 250                 255     


Glu Pro Ser Lys Glu Ile Thr Ser His Glu Glu Gly Gly Gly Asp Val 
            260                 265                 270         


Ser Pro Arg Lys Glu Pro Gln Glu Pro Glu Val Cys Pro Thr Lys Ile 
        275                 280                 285             


Lys Pro Asn Leu Ser Ser Ser Pro Arg Ser Glu Glu Thr Thr Ala Ser 
    290                 295                 300                 


Ser Leu Val Trp Pro Leu Pro Ala His Leu Pro Glu Glu Asp Leu Pro 
305                 310                 315                 320 


Glu Gly Gly Ser Thr Val Ser Ala Pro Thr Ala Ser Gly Met Ser Ser 
                325                 330                 335     


Pro Glu His Asn Gln Pro Pro Val Ala Leu Leu Asp Thr Glu Glu Met 
            340                 345                 350         


Ser Val Pro Gln Asp Cys His Leu Leu Pro Ser Thr Glu Ser Phe Ser 
        355                 360                 365             


Gly Gly Val Ser Glu Asp Val Ile Ser Arg Pro His Ser Pro Pro Glu 
    370                 375                 380                 


Ile Val Ser Arg Glu Glu Ser Pro Gln Cys Ser Glu Asn Gln Ser Ser 
385                 390                 395                 400 


Pro Met Gly Leu Glu Pro Pro Met Ser Leu Gly Lys Ala Glu Asp Asn 
                405                 410                 415     


Gln Ser Ile Ser Ala Glu Val Glu Ser Gly Asp Thr Gln Glu Leu Asn 
            420                 425                 430         


Val Asp Pro Leu Leu Lys Glu Ser Ser Thr Phe Thr Asp Glu Asn Pro 
        435                 440                 445             


Ser Glu Thr Glu Glu Ser Glu Ala Ala Gly Gly Ile Gly Lys Leu Glu 
    450                 455                 460                 


Gly Glu Asp Gly Asp Val Lys Cys Leu Ser Glu Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Thr Ser Ile Asp Ser Leu Glu Glu Asn Leu Asp Lys Lys Lys Lys Gly 
                485                 490                 495     


Lys Lys Phe Pro Glu Ala Ser Asp Arg Cys Leu Arg Ser Gln Leu Ser 
            500                 505                 510         


Asp Ser Ser Ser Ala Asp Arg Cys Leu Arg Asn Gln Ser Ser Asp Ser 
        515                 520                 525             


Ser Ser Ala Cys Leu Glu Ile Lys Val Pro Lys Asn Pro Ser Ala Lys 
    530                 535                 540                 


Arg Ser Lys Lys Glu Gly His Pro Gly Gly Thr Thr Pro Lys Gly Leu 
545                 550                 555                 560 


Leu Pro Asp Ser Phe His Thr Glu Thr Leu Glu Asp Thr Glu Lys Pro 
                565                 570                 575     


Ser Val Asn Glu Arg Pro Ser Glu Lys Asp Ala Glu Gln Glu Gly Glu 
            580                 585                 590         


Gly Gly Gly Ile Ile Thr Arg Gln Thr Leu Lys Asn Met Leu Asp Lys 
        595                 600                 605             


Glu Val Lys Glu Leu Arg Gly Glu Ile Phe Pro Ser Arg Asp Pro Ile 
    610                 615                 620                 


Thr Thr Ala Gly Gln Pro Leu Pro Gly Glu Arg Leu Glu Ile Tyr Val 
625                 630                 635                 640 


Gln Ser Lys Met Asp Glu Lys Asn Ala His Ile Pro Ser Glu Ser Ile 
                645                 650                 655     


Ala Cys Lys Arg Asp Pro Glu Gln Ala Lys Glu Glu Pro Gly His Ile 
            660                 665                 670         


Pro Thr Gln His Val Glu Glu Ala Val Asn Glu Val Asp Asn Glu Asn 
        675                 680                 685             


Thr Gln Gln Lys Asp Asp Glu Ser Asp Ala Pro Cys Ser Ser Leu Gly 
    690                 695                 700                 


Leu Ser Ser Ser Gly Ser Gly Asp Ala Ala Arg Ala Pro Lys Ser Val 
705                 710                 715                 720 


Pro Arg Pro Lys Arg Leu Thr Ser Ser Thr Tyr Asn Leu Arg His Ala 
                725                 730                 735     


His Ser Leu Gly Ser Leu Asp Ala Ser Lys Val Thr Ser Glu Lys Glu 
            740                 745                 750         


Ala Ala Gln Val Asn Pro Ile Met Pro Lys Glu Asn Gly Ala Ser Glu 
        755                 760                 765             


Ser Gly Asp Pro Leu Asp Glu Asp Asp Val Asp Thr Val Val Asp Glu 
    770                 775                 780                 


Gln Pro Lys Phe Met Glu Trp Cys Ala Glu Glu Glu Asn Gln Glu Leu 
785                 790                 795                 800 


Ile Ala Asn Phe Asn Ala Gln Tyr Met Lys Val Gln Lys Gly Trp Ile 
                805                 810                 815     


Gln Leu Glu Lys Glu Gly Gln Pro Thr Pro Arg Ala Arg Asn Lys Ser 
            820                 825                 830         


Asp Lys Leu Lys Glu Ile Trp Lys Ser Lys Lys Arg Ser Arg Lys Cys 
        835                 840                 845             


Arg Ser Ser Leu Glu Ser Gln Lys Cys Ser Pro Val Gln Met Leu Phe 
    850                 855                 860                 


Met Thr Asn Phe Lys Leu Ser Asn Val Cys Lys Trp Phe Leu Glu Thr 
865                 870                 875                 880 


Thr Glu Thr Arg Ser Leu Val Ile Val Lys Lys Leu Asn Thr Arg Leu 
                885                 890                 895     


Pro Gly Asp Val Pro Pro Val Lys His Pro Leu Gln Lys Tyr Ala Pro 
            900                 905                 910         


Ser Ser Leu Tyr Pro Ser Ser Leu Gln Ala Glu Arg Leu Lys Lys His 
        915                 920                 925             


Leu Lys Lys Phe Pro Gly Ala Thr Pro Ala Lys Asn Asn Trp Lys Met 
    930                 935                 940                 


Gln Lys Leu Trp Ala Lys Phe Arg Glu Asn Pro Asp Gln Val Glu Pro 
945                 950                 955                 960 


Glu Asp Gly Ser Asp Val Ser Pro Gly Pro Asn Ser Glu Asp Ser Ile 
                965                 970                 975     


Glu Glu Val Lys Glu Asp Arg Asn Ser His Pro Pro Ala Asn Leu Pro 
            980                 985                 990         


Thr Pro Ala Ser Thr Arg Ile Leu  Arg Lys Tyr Ser Asn  Ile Arg Gly 
        995                 1000                 1005             


Lys Leu  Arg Ala Gln Gln Arg  Leu Ile Lys Asn Glu  Lys Met Glu 
    1010                 1015                 1020             


Cys Pro  Asp Ala Leu Ala Val  Glu Ser Lys Pro Ser  Arg Lys Ser 
    1025                 1030                 1035             


Val Cys  Ile Asn Pro Leu Met  Ser Pro Lys Leu Ala  Leu Gln Val 
    1040                 1045                 1050             


Asp Ala  Asp Gly Phe Pro Val  Lys Pro Lys Ser Thr  Glu Gly Met 
    1055                 1060                 1065             


Lys Gly  Arg Lys Gly Lys Gln  Val Ser Glu Ile Leu  Pro Lys Ala 
    1070                 1075                 1080             


Glu Val  Gln Ser Lys Arg Lys  Arg Thr Glu Gly Ser  Ser Pro Pro 
    1085                 1090                 1095             


Asp Ser  Lys Asn Lys Gly Pro  Thr Val Lys Ala Ser  Lys Glu Lys 
    1100                 1105                 1110             


His Ala  Asp Gly Ala Thr Lys  Thr Pro Ala Ala Lys  Arg Pro Ala 
    1115                 1120                 1125             


Ala Arg  Asp Arg Ser Ser Gln  Pro Pro Lys Lys Thr  Ser Leu Lys 
    1130                 1135                 1140             


Glu Asn  Lys Val Lys Ile Pro  Lys Lys Ser Ala Gly  Lys Ser Cys 
    1145                 1150                 1155             


Pro Pro  Ser Arg Lys Glu Lys  Glu Asn Thr Asn Lys  Arg Pro Ser 
    1160                 1165                 1170             


Gln Ser  Ile Ala Ser Glu Thr  Leu Thr Lys Pro Ala  Lys Gln Lys 
    1175                 1180                 1185             


Gly Ala  Gly Glu Ser Ser Ser  Arg Pro Gln Lys Ala  Thr Asn Arg 
    1190                 1195                 1200             


Lys Gln  Ser Ser Gly Lys Thr  Arg Ala Arg Pro Ser  Thr Lys Thr 
    1205                 1210                 1215             


Pro Glu  Ser Ser Ala Ala Gln  Arg Lys Arg Lys Leu  Lys Ala Lys 
    1220                 1225                 1230             


Leu Asp  Cys Ser His Ser Lys  Arg Arg Arg Leu Asp  Ala Lys 
    1235                 1240                 1245         


<210>  299
<211>  2487
<212>  DNA
<213>  Homo sapiens

<400>  299
atggcgaggc tctgccggcg tgtcccctgc accctgcttc tcggcctggc cgtggtgctg       60

ctgaaagcgc ggctggtccc cgcggccgcc agagcggaac tcagccgctc cgacctcagc      120

ctcatccaac agcagcagca gcagcagcag cagcaacaac aacaacaaca gcaaaagcag      180

ctggaggagg ctgaggagga gaggacagag gtgcctgggg caacctccac cttgacggtt      240

ccagtgtctg tatttatgtt gaaagtccag gtgaatgaca tcatcagtcg tcagtacctg      300

agccaagcag ttgtagaagt gtttgtaaac tacacgaaga caaattccac agtaactaaa      360

agcaatggag cagtgctgat aaaagtaccc tacaaattag gacttagttt aactattatt      420

gcttacaaag atggctacgt gttgacccct ctgccttgga aaaccagaag aatgccaata      480

tattcatcag ttacactttc actgttcccg caaagccaag caaatatatg gctatttgaa      540

gacactgttt taattactgg aaaattagct gatgccaagt ctcaaccaag tgttcagttt      600

tcaaaagcct taattaaact tcctgacaac catcatatta gcaacgttac tggctatctt      660

acagttctac aacagttttt gaaagtggac aattttctgc atacaactgg aattactctc      720

aataaaccag gttttgaaaa cattgaattg actcctcttg ctgcaatatg tgtgaaaata      780

tattctggag gaaaagaact aaaggtcaat ggctctattc aagtttctct tcctcttcta      840

cgtctgaatg atataagtgc aggggatcgc atacctgctt ggacatttga tatgaacaca      900

ggtgcttgga taaatcatgg tcggggaatg gtcaaggaac ataacaatca tttaatctgg      960

acatatgatg caccacattt ggggtactgg atagcagctc cacttccagg aactagaggt     1020

tcaggtataa atgaagattc caaggacata actgcctacc acacagtgtt tcttacagcc     1080

atattaggag gaacaatagt cattgtcatt ggattttttg ctgtactact ttgttattgc     1140

agggacaagt gtggtactcc acagaaaaga gaaagaaata tcactaaact tgaggtcctc     1200

aagagagacc agacaacttc aacaacacac ataaatcata tcagtacagt taaagttgca     1260

ttaaaagctg aggacaagtc gcagttattc aatgccaaaa actcctcata tagtcctcag     1320

aaaaaggaac catcaaaggc agaaacagaa gaaagagttt ccatggtaaa aactcgggac     1380

gattttaaaa tctacaatga agatgtttca tttctatcag tcaatcaaaa taattactca     1440

agaaacccaa cacagtcttt ggagcccaat gtagggtcca aacaacctaa acatattaac     1500

aacaatctat cttcatctct aggtgatgct caagatgaaa agaggtatct cacaggtaat     1560

gaggaggcgt atgggcgttc ccatattcct gaacagctta tgcatattta cagccaaccc     1620

attgccatcc ttcaaacatc tgaccttttc tccacaccgg aacaattaca tactgctaag     1680

tcagctactt tgccaagaaa gggacagtta gtctatggcc aattgatgga accagtaaat     1740

cgagagaact ttacgcagac cttgcccaaa atgccaattc attcccatgc acagccccca     1800

gatgccaggg aagaggatat catacttgaa ggtcaacaga gcctgccatc ccaggcttca     1860

gattggagcc gatactcaag cagcttactg gaatccgtct ctgttcctgg aacactaaat     1920

gaggctgttg taatgactcc attttcatcg gaacttcaag gaatttcaga acagaccctc     1980

ctggagctgt ccaaaggaaa gccctccccg catcccagag cctggtttgt gtctcttgat     2040

ggaaagccag ttgcacaagt gaggcactcc tttatagacc tgaaaaaggg caagagaacc     2100

cagagcaatg acaccagtct ggactctggg gtggacatga atgagcttca ctcaagtaga     2160

aagctcgaga gggagaaaac attcatcaaa agcatgcatc agcccaagat cctttactta     2220

gaagatttag acctaagcag cagtgagagt ggaaccaccg tctgttcccc tgaagaccca     2280

gctttaaggc acatcctaga tggagggagt ggagtgatca tggagcaccc tggagaagag     2340

tcgccaggaa ggaaaagcac tgttgaagat tttgaagcta atacatcccc cactaaaaga     2400

aggggcagac caccactagc caaaagagat agcaagacta acatctggaa gaagcgagag     2460

gaacgcccac tgattcccat aaattaa                                         2487


<210>  300
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu 
1               5                   10                  15      


Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala 
            20                  25                  30          


Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala 
    50                  55                  60                  


Glu Glu Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val 
65                  70                  75                  80  


Pro Val Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser 
                85                  90                  95      


Arg Gln Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr 
            100                 105                 110         


Lys Thr Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys 
        115                 120                 125             


Val Pro Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp 
    130                 135                 140                 


Gly Tyr Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile 
145                 150                 155                 160 


Tyr Ser Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile 
                165                 170                 175     


Trp Leu Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala 
            180                 185                 190         


Lys Ser Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro 
        195                 200                 205             


Asp Asn His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln 
    210                 215                 220                 


Gln Phe Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu 
225                 230                 235                 240 


Asn Lys Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile 
                245                 250                 255     


Cys Val Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser 
            260                 265                 270         


Ile Gln Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly 
        275                 280                 285             


Asp Arg Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Ile 
    290                 295                 300                 


Asn His Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp 
305                 310                 315                 320 


Thr Tyr Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro 
                325                 330                 335     


Gly Thr Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala 
            340                 345                 350         


Tyr His Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile 
        355                 360                 365             


Val Ile Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys 
    370                 375                 380                 


Gly Thr Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu 
385                 390                 395                 400 


Lys Arg Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr 
                405                 410                 415     


Val Lys Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala 
            420                 425                 430         


Lys Asn Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu 
        435                 440                 445             


Thr Glu Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile 
    450                 455                 460                 


Tyr Asn Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser 
465                 470                 475                 480 


Arg Asn Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro 
                485                 490                 495     


Lys His Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp 
            500                 505                 510         


Glu Lys Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His 
        515                 520                 525             


Ile Pro Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu 
    530                 535                 540                 


Gln Thr Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys 
545                 550                 555                 560 


Ser Ala Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met 
                565                 570                 575     


Glu Pro Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro 
            580                 585                 590         


Ile His Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile 
        595                 600                 605             


Leu Glu Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg 
    610                 615                 620                 


Tyr Ser Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn 
625                 630                 635                 640 


Glu Ala Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser 
                645                 650                 655     


Glu Gln Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro 
            660                 665                 670         


Arg Ala Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg 
        675                 680                 685             


His Ser Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp 
    690                 695                 700                 


Thr Ser Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg 
705                 710                 715                 720 


Lys Leu Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys 
                725                 730                 735     


Ile Leu Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr 
            740                 745                 750         


Thr Val Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly 
        755                 760                 765             


Gly Ser Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg 
    770                 775                 780                 


Lys Ser Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg 
785                 790                 795                 800 


Arg Gly Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp 
                805                 810                 815     


Lys Lys Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn 
            820                 825             


<210>  301
<211>  8616
<212>  DNA
<213>  Homo sapiens

<400>  301
atgcgtcgag ggcgtctgct ggagatcgcc ctgggattta ccgtgctttt agcgtcctac       60

acgagccatg gggcggacgc caatttggag gctgggaacg tgaaggaaac cagagccagt      120

cgggccaaga gaagaggcgg tggaggacac gacgcgctta aaggacccaa tgtctgtgga      180

tcacgttata atgcttactg ttgccctgga tggaaaacct tacctggcgg aaatcagtgt      240

attgtcccca tttgccggca ttcctgtggg gatggatttt gttcgaggcc aaatatgtgc      300

acttgcccat ctggtcagat agctccttcc tgtggctcca gatccataca acactgcaat      360

attcgctgta tgaatggagg tagctgcagt gacgatcact gtctatgcca gaaaggatac      420

atagggactc actgtggaca acctgtttgt gaaagtggct gtctcaatgg aggaaggtgt      480

gtggccccaa atcgatgtgc atgcacttac ggatttactg gaccccagtg tgaaagagat      540

tacaggacag gcccatgttt tactgtgatc agcaaccaga tgtgccaggg acaactcagc      600

gggattgtct gcacaaaaac gctctgctgt gccacagtcg gccgagcctg gggccacccc      660

tgtgagatgt gtcctgccca gcctcacccc tgccgccgtg gcttcattcc aaatatccgc      720

acgggagctt gtcaagatgt ggatgaatgc caggccatcc ccgggctctg tcagggagga      780

aattgcatta atactgttgg gtcttttgag tgcaaatgcc ctgctggaca caaacttaat      840

gaagtgtcac aaaaatgtga agatattgat gaatgcagca ccattcctgg aatctgtgaa      900

gggggtgaat gtacaaacac agtcagcagt tacttttgca aatgtccccc tggtttttac      960

acctctccag atggtaccag atgcatagat gttcgcccag gatactgtta cacagctctg     1020

acaaacgggc gctgctctaa ccagctgcca cagtccataa ccaaaatgca gtgctgctgt     1080

gatgccggcc gatgctggtc tccaggggtc actgtcgccc ctgagatgtg tcccatcaga     1140

gcaaccgagg atttcaacaa gctgtgctct gttcctatgg taattcctgg gagaccagaa     1200

tatcctcccc caccccttgg ccccattcct ccagttctcc ctgttcctcc tggctttcct     1260

cctggacctc aaattccggt ccctcgacca ccagtggaat atctgtatcc atctcgggag     1320

ccaccaaggg tgctgccagt aaacgttact gattactgcc agttggtccg ctatctctgt     1380

caaaatggac gctgcattcc aactcctggg agttgccggt gtgagtgcaa caaagggttc     1440

cagctggacc tccgtgggga gtgtattgat gttgatgaat gtgagaaaaa cccctgtgct     1500

ggtggtgagt gtattaacaa ccagggttcg tacacctgtc agtgccgagc tggatatcag     1560

agcacactca cgcggacaga atgccgagac attgatgagt gtttacagaa tggccggatc     1620

tgcaataatg gacgctgcat caacacagat ggcagttttc attgcgtgtg taatgcgggc     1680

tttcatgtta cacgagatgg gaagaactgt gaagatatgg atgaatgcag cataaggaac     1740

atgtgcctta atggaatgtg tatcaatgaa gatggcagtt ttaaatgtat ttgcaaacct     1800

ggattccagc tggcatcaga tggacgttat tgcaaagaca ttaacgagtg tgaaacccct     1860

gggatctgca tgaatgggcg ttgcgtcaac actgatggct cctacagatg tgaatgcttc     1920

cctggactgg ctgtgggtct ggatggccgt gtgtgtgttg acacacacat gcggagcaca     1980

tgctatggtg gatacaagag aggccagtgt atcaaacctt tgtttggtgc tgtcactaaa     2040

tctgaatgct gttgcgccag cactgagtat gcatttgggg aaccttgcca gccgtgtcct     2100

gcacagaatt cagcggaata tcaggcactc tgcagcagtg ggccaggaat gacgtcagca     2160

ggcagtgata taaatgaatg tgcactagat cctgatattt gcccaaatgg aatctgtgaa     2220

aaccttcgtg ggacctataa atgtatatgc aattcaggat atgaagtgga ttcaactggg     2280

aaaaactgcg ttgatattaa tgaatgtgta ctgaacagtc tcctttgtga caatggacaa     2340

tgtagaaata ctcctggaag ttttgtctgt acctgcccca agggatttat ctacaaacct     2400

gatctaaaaa catgtgaaga cattgatgaa tgcgaatcaa gtccttgcat taatggagtc     2460

tgcaagaaca gcccaggctc ttttatttgt gaatgttctt ctgaaagtac tttggatcca     2520

acaaaaacca tctgcataga aaccatcaag ggcacttgct ggcagactgt cattgatggg     2580

cgatgtgaga tcaacatcaa tggagccacc ttaaagtccc agtgctgctc ctccctcggt     2640

gctgcgtggg gaagcccgtg caccctatgc caagttgatc ccatatgtgg taaagggtac     2700

tcaagaatta aaggaacaca atgtgaagat atagatgaat gtgaagtgtt cccaggagtg     2760

tgtaaaaatg gcctgtgtgt taacactagg gggtcattca agtgtcagtg tcccagtgga     2820

atgactttgg atgccacagg aaggatctgt cttgatatcc gcctggaaac ctgcttcctg     2880

aggtacgagg acgaggagtg caccctgcct attgctggcc gccaccgcat ggacgcctgc     2940

tgctgctccg tcggggcagc ctggggtact gaggaatgcg aggagtgtcc catgagaaat     3000

actcctgagt acgaggagct gtgtccgaga ggacccggat ttgccacaaa agaaattaca     3060

aatggaaagc ctttcttcaa agatatcaat gagtgcaaga tgatacccag cctctgcacc     3120

cacggcaagt gcagaaacac cattggcagc tttaagtgca ggtgtgacag cggctttgct     3180

cttgattctg aagaaaggaa ctgcacagac attgacgaat gccgcatatc tcctgacctc     3240

tgtggcagag gccagtgtgt gaacacccct ggggactttg aatgcaagtg tgacgaaggc     3300

tatgaaagtg gattcatgat gatgaagaac tgcatggata ttgatgagtg tcagagagat     3360

cctctcctat gccgaggtgg tgtttgccat aacacagagg gaagttaccg ctgtgaatgc     3420

ccgcctggcc atcagctgtc ccccaacatc tccgcgtgta tcgacatcaa tgaatgtgag     3480

ctgagtgcac acctgtgccc caatggccgt tgcgtgaacc tcatagggaa gtatcagtgt     3540

gcctgcaacc ctggctacca ttcaactccc gataggctat tttgtgttga cattgatgaa     3600

tgcagcataa tgaatggtgg ttgtgaaacc ttctgcacaa actctgaagg cagctatgaa     3660

tgtagctgtc agccgggatt tgcactaatg cctgaccaga gatcatgcac cgacatcgat     3720

gagtgtgaag ataatcccaa tatctgtgat ggtggtcagt gcacaaatat ccctggagag     3780

tacaggtgct tgtgttatga tggattcatg gcatctgaag acatgaagac ttgtgtagat     3840

gtcaatgagt gtgacctgaa tccaaatatc tgcctaagtg ggacctgtga aaacacgaaa     3900

ggctcattta tctgccactg tgatatgggc tactccggca aaaaaggaaa aactggctgt     3960

acagacatca atgaatgtga aattggagca cacaactgtg gcaaacatgc tgtatgtacc     4020

aatacagcag gaagcttcaa atgtagctgc agtcccgggt ggattggaga tggcattaag     4080

tgcactgatc tggacgaatg ttccaatgga acccatatgt gcagccagca tgcagactgc     4140

aagaatacca tgggatctta ccgctgtctg tgcaaggaag gatacacagg tgatggcttc     4200

acttgtacag accttgatga gtgctctgag aacctgaatc tctgtggcaa tggccagtgc     4260

ctcaatgcac caggaggata ccgctgtgaa tgcgacatgg gcttcgtgcc cagtgctgac     4320

gggaaagcct gtgaagatat tgatgagtgc tcccttccga acatctgtgt ctttggaact     4380

tgccacaacc tccctggcct gttccgctgt gagtgtgaga taggctacga actggacaga     4440

agcggcggga actgcacaga tgtgaatgaa tgcctggatc caaccacgtg catcagtggg     4500

aactgtgtca acactccagg cagctatatc tgtgactgcc cacctgattt tgaactgaac     4560

ccaactcgag ttggctgtgt tgatacccgc tctggaaatt gctatttgga tattcgacct     4620

cgaggagaca atggagatac agcctgcagc aatgaaattg gagttggtgt ttccaaagct     4680

tcctgctgct gttctctggg taaagcctgg ggtactcctt gtgagatgtg tcctgctgtg     4740

aacacatccg agtacaaaat tctttgtcct ggaggggaag gtttccgacc aaatcctatc     4800

accgttatat tggaagatat tgatgagtgc caggagctac cagggctgtg ccaaggagga     4860

aaatgtatca acacctttgg gagtttccag tgccgctgtc caaccggcta ctacctgaat     4920

gaagatacac gagtgtgtga tgatgtgaat gaatgtgaga ctcctggaat ctgtggtcca     4980

gggacatgtt acaacaccgt tggcaactac acctgtatct gtcctccaga ctacatgcaa     5040

gtgaatgggg gaaataattg catggatatg agaagaagtt tgtgctacag aaactactat     5100

gctgacaacc agacctgtga tggagaattg ttattcaaca tgaccaagaa gatgtgctgc     5160

tgttcctaca acattggccg ggcgtggaac aagccctgtg aacagtgtcc catcccaagt     5220

acagatgagt ttgctacact ctgtggaagt caaaggccag gctttgtcat cgacatttat     5280

accggtttac ccgttgatat tgatgagtgc cgggagatcc caggggtctg tgaaaatgga     5340

gtgtgtatca acatggttgg cagcttccga tgtgaatgtc cagtgggatt cttctataat     5400

gacaagttgt tggtttgtga agatattgac gagtgtcaga acggcccagt gtgccagcgc     5460

aacgccgaat gcatcaacac tgcaggcagc taccgctgtg actgtaagcc cggctaccgc     5520

ttcacctcca caggacagtg caatgatcgt aatgaatgtc aagaaatccc caatatatgc     5580

agtcatgggc agtgcattga cacagttgga agcttttatt gcctttgcca cactggtttt     5640

aaaacaaatg atgaccaaac catgtgcttg gacataaatg aatgtgaaag agatgcctgt     5700

gggaatggaa cttgccggaa cacaattggt tccttcaact gccgctgcaa tcatggtttc     5760

atcctttctc acaacaatga ctgtatagat gttgatgaat gtgcaagtgg aaatgggaat     5820

ctttgcagaa atggccaatg cattaataca gtggggtctt tccagtgcca gtgcaatgaa     5880

ggctatgagg tggctccaga tgggaggacc tgtgtggata tcaatgaatg tcttctagaa     5940

cccagaaaat gtgcaccagg tacctgtcaa aacttggatg ggtcctacag atgcatttgc     6000

ccacctggat acagtcttca aaatgagaag tgtgaagata ttgatgagtg tgtcgaagag     6060

ccagaaattt gtgccctggg cacatgcagt aacactgaag gcagcttcaa atgtctgtgt     6120

ccagaagggt tttccttgtc ctccagtgga agaaggtgcc aagatttgcg aatgagctac     6180

tgttatgcga agtttgaagg aggaaagtgt tcatcaccca aatccagaaa tcactccaag     6240

caggaatgct gctgtgcctt gaagggagaa ggctggggag acccctgcga gctctgcccc     6300

acggaacctg atgaggcctt ccgccagata tgtccttatg gaagtgggat catcgtggga     6360

cctgatgatt cagcagttga tatggacgaa tgcaaagaac ccgatgtctg taaacatgga     6420

cagtgcatca atacagatgg ttcctatcgc tgcgagtgtc cctttggtta tattctagca     6480

gggaatgaat gtgtagatac tgatgaatgt tctgttggca atccttgtgg aaatggaacc     6540

tgcaagaatg tgattggagg ttttgaatgc acctgcgagg agggatttga gcccggtcca     6600

atgatgacat gtgaagatat aaatgaatgt gcccagaatc ctctgctctg tgccttccga     6660

tgtgtgaaca cttatgggtc atatgaatgc aaatgtcccg tgggatatgt gctcagagaa     6720

gaccgtagga tgtgcaaaga tgaggatgag tgtgaagagg gaaaacatga ctgtactgaa     6780

aaacaaatgg aatgcaagaa cctcattggc acatatatgt gcatctgtgg acccgggtat     6840

cagcggagac ctgatggaga aggctgtgta gatgagaatg aatgtcagac gaagccaggg     6900

atctgtgaga atgggcgctg cctcaacacc cgtgggagct acacctgtga gtgtaatgat     6960

gggtttaccg ccagccccaa ccaggacgag tgccttgaca atcgggaagg gtactgcttc     7020

acagaggtgc tacaaaacat gtgtcagatc ggctccagca acaggaaccc cgtcaccaaa     7080

tcggaatgct gctgtgacgg agggagaggc tggggtcccc actgtgagat ctgccctttc     7140

caggggactg tggctttcaa gaaactctgt ccccatggcc gaggattcat gaccaatgga     7200

gcagatatcg atgaatgcaa ggttattcac gatgtttgcc gaaatgggga atgtgtcaat     7260

gacagaggat catatcattg catttgtaaa actgggtaca ctccagatat aactgggact     7320

tcctgtgtag atctgaacga gtgcaaccag gctcccaaac cctgcaattt tatctgcaaa     7380

aacacagaag ggagttacca gtgttcatgc ccgaaaggct acattctgca agaggatgga     7440

aggagctgca aagatcttga tgagtgtgca accaagcaac acaactgcca gttcctatgt     7500

gttaacacca ttggcggctt cacatgcaaa tgtcctcccg gatttaccca acaccatacg     7560

tcctgcattg ataacaatga atgcacctct gacatcaatc tgtgcgggtc taagggcatt     7620

tgccagaaca ctcctggaag cttcacctgt gaatgccagc ggggattctc acttgatcag     7680

accggctcca gctgtgaaga cgtggacgag tgtgagggta accaccgctg ccagcatggc     7740

tgccagaaca tcattggggg ctacaggtgc agctgccccc agggctacct ccagcactac     7800

cagtggaacc agtgtgttga tgaaaacgaa tgcctcagcg ctcacatctg cggaggagcc     7860

tcctgtcaca acaccctggg gagctacaag tgcatgtgtc ccgccggctt ccagtatgaa     7920

cagttcagtg gaggatgcca agacatcaat gaatgtggct ctgcgcaggc cccctgcagc     7980

tatggctgtt ccaataccga gggcggttac ctgtgtggct gtccacctgg ttacttccgc     8040

ataggccaag ggcactgtgt ttctggaatg ggcatgggcc gaggaaaccc agagccacct     8100

gtcagtggtg aaatggatga caattcactc tccccagagg cttgttacga gtgtaagatc     8160

aatggctacc ccaaacgggg caggaaacgg agaagcacaa acgaaactga tgcctccaat     8220

atcgaggatc agtctgagac agaagccaat gtgagtcttg caagttggga tgttgagaag     8280

acagccatct ttgctttcaa tatttcccac gtcagtaaca aggttcgaat cctagaactc     8340

cttccagctc ttacaactct gacgaatcac aacagatact tgatcgaatc tggaaatgaa     8400

gatggcttct ttaaaatcaa ccaaaaggaa gggatcagct acctccactt cacaaagaag     8460

aagccagtgg ctggaaccta ttcattacaa atcagtagta ctccacttta taaaaagaaa     8520

gaacttaacc aactagaaga caaatatgac aaagactacc tcagtggtga actgggtgat     8580

aatctgaaga tgaaaatcca ggttttgctt cattaa                               8616


<210>  302
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Cys Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  303
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  303
atgaaggggg caagtgagga gaagctggca tctgtgtcca acctggtcac tgtgtttgag       60

aatagcagga ccccagaagc agcacccaga ggccagaggc tagaggacgt gcatcaccgc      120

cctgagtgca ggcctcccga gtccccagga ccacgggaga agacgaatgt cggggaggcc      180

gtggggtctg agcccaggac agtcagcagg aggtacctga actccctgaa gaacaagctg      240

tccagcgaag cctggaggaa atcttgccag cctgtgaccc tctcaggatc ggggacgcag      300

gagccagaga agaagatcgt ccaggagctg ctggagacag agcaggccta tgtggcgcgc      360

ctccacctgc tagaccaggt gtttttccag gagctgctga agacagcccg cagcagcaag      420

gccttcccag aggatgtggt cagggtcatc ttctccaaca tctcctccat ctatcagttc      480

cattctcagt tcttcctccc agagctgcag cggcgcctgg acgactggac agctaacccc      540

cgcatcggtg acgtgatcca gaagctggcc cccttcctga agatgtacag tgagtatgtc      600

aagaactttg agcgagcggc tgagctgctg gccacctgga ccgacaagtc tccactcttc      660

caggaggttc tcactcgcat ccagagcagc gaggcttcgg gcagcctgac cctgcagcac      720

cacatgctgg aaccagtgca gagaattcca cgttacgagc tgctgctcaa ggagtacatc      780

cagaagctgc cagcccaggc cccagaccag gccgatgccc agaaagccct ggacatgatc      840

ttctcagctg cccagcactc caatgcagcc atcactgaga tggagcggct gcaggacctg      900

tgggaggtgt accagcgcct gggcctcgag gacgacatag tagacccctc taacaccctg      960

ctccgtgagg gcccggtcct caagatctcc ttccgccgca acgaccccat ggagcgctac     1020

cttttcttgt tcaacaacat gctgctctac tgtgtgccca gggtgatcca ggtgggcgcc     1080

cagttccagg tgaggacccg catcgatgtg gccgggatga aggtgcggga gctgatggat     1140

gctgagtttc cccactcctt cctggtgtcc gggaagcagc gcaccctgga gctgcaagcc     1200

cggtcccagg aggaaatgat ttcctggatg caggccttcc aagcagccat tgaccaaatc     1260

gagaagcgga atgaaacctt caaggctgcg gcccaggggc ctgagggaga catccaggag     1320

caggagctgc agtctgagga gctgggcctc cgggcaccgc agtgggtccg ggacaagatg     1380

gtgaccatgt gcatgcgctg ccaggagccc ttcaacgctc tgacgcgccg tcgccaccac     1440

tgccgggcct gcggctatgt ggtgtgtgcc aggtgctccg actaccgggc cgaactgaaa     1500

tacgacgaca acaggcccaa ccgagtctgc ctccactgct acgcattcct cactggaaat     1560

gtgctgcctg aggccaagga ggacaagagg cggggcatcc tggagaaagg gtcctcagcc     1620

acgcctgacc agagcctgat gtgcagcttc ctgcagctca tcggggacaa gtggggcaag     1680

agcggccccc ggggctggtg tgtgatccct cgggatgacc ccctcgtgct ctatgtctat     1740

gctgcccctc aggacatgag ggctcacacc tccatccccc tgctgggcta ccaggtgact     1800

gttgggcccc agggggaccc tcgggtcttc cagctacagc agtcaggcca gctctacacc     1860

ttcaaggccg agacggagga gctgaagggc cgctgggtga aggccatgga gcgggcggcc     1920

agtggctgga gccccagctg gcccaacgat ggggacctgt ccgactga                  1968


<210>  304
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Lys Gly Ala Ser Glu Glu Lys Leu Ala Ser Val Ser Asn Leu Val 
1               5                   10                  15      


Thr Val Phe Glu Asn Ser Arg Thr Pro Glu Ala Ala Pro Arg Gly Gln 
            20                  25                  30          


Arg Leu Glu Asp Val His His Arg Pro Glu Cys Arg Pro Pro Glu Ser 
        35                  40                  45              


Pro Gly Pro Arg Glu Lys Thr Asn Val Gly Glu Ala Val Gly Ser Glu 
    50                  55                  60                  


Pro Arg Thr Val Ser Arg Arg Tyr Leu Asn Ser Leu Lys Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Arg Lys Ser Cys Gln Pro Val Thr Leu Ser Gly 
                85                  90                  95      


Ser Gly Thr Gln Glu Pro Glu Lys Lys Ile Val Gln Glu Leu Leu Glu 
            100                 105                 110         


Thr Glu Gln Ala Tyr Val Ala Arg Leu His Leu Leu Asp Gln Val Phe 
        115                 120                 125             


Phe Gln Glu Leu Leu Lys Thr Ala Arg Ser Ser Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asp Val Val Arg Val Ile Phe Ser Asn Ile Ser Ser Ile Tyr Gln Phe 
145                 150                 155                 160 


His Ser Gln Phe Phe Leu Pro Glu Leu Gln Arg Arg Leu Asp Asp Trp 
                165                 170                 175     


Thr Ala Asn Pro Arg Ile Gly Asp Val Ile Gln Lys Leu Ala Pro Phe 
            180                 185                 190         


Leu Lys Met Tyr Ser Glu Tyr Val Lys Asn Phe Glu Arg Ala Ala Glu 
        195                 200                 205             


Leu Leu Ala Thr Trp Thr Asp Lys Ser Pro Leu Phe Gln Glu Val Leu 
    210                 215                 220                 


Thr Arg Ile Gln Ser Ser Glu Ala Ser Gly Ser Leu Thr Leu Gln His 
225                 230                 235                 240 


His Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu 
                245                 250                 255     


Lys Glu Tyr Ile Gln Lys Leu Pro Ala Gln Ala Pro Asp Gln Ala Asp 
            260                 265                 270         


Ala Gln Lys Ala Leu Asp Met Ile Phe Ser Ala Ala Gln His Ser Asn 
        275                 280                 285             


Ala Ala Ile Thr Glu Met Glu Arg Leu Gln Asp Leu Trp Glu Val Tyr 
    290                 295                 300                 


Gln Arg Leu Gly Leu Glu Asp Asp Ile Val Asp Pro Ser Asn Thr Leu 
305                 310                 315                 320 


Leu Arg Glu Gly Pro Val Leu Lys Ile Ser Phe Arg Arg Asn Asp Pro 
                325                 330                 335     


Met Glu Arg Tyr Leu Phe Leu Phe Asn Asn Met Leu Leu Tyr Cys Val 
            340                 345                 350         


Pro Arg Val Ile Gln Val Gly Ala Gln Phe Gln Val Arg Thr Arg Ile 
        355                 360                 365             


Asp Val Ala Gly Met Lys Val Arg Glu Leu Met Asp Ala Glu Phe Pro 
    370                 375                 380                 


His Ser Phe Leu Val Ser Gly Lys Gln Arg Thr Leu Glu Leu Gln Ala 
385                 390                 395                 400 


Arg Ser Gln Glu Glu Met Ile Ser Trp Met Gln Ala Phe Gln Ala Ala 
                405                 410                 415     


Ile Asp Gln Ile Glu Lys Arg Asn Glu Thr Phe Lys Ala Ala Ala Gln 
            420                 425                 430         


Gly Pro Glu Gly Asp Ile Gln Glu Gln Glu Leu Gln Ser Glu Glu Leu 
        435                 440                 445             


Gly Leu Arg Ala Pro Gln Trp Val Arg Asp Lys Met Val Thr Met Cys 
    450                 455                 460                 


Met Arg Cys Gln Glu Pro Phe Asn Ala Leu Thr Arg Arg Arg His His 
465                 470                 475                 480 


Cys Arg Ala Cys Gly Tyr Val Val Cys Ala Arg Cys Ser Asp Tyr Arg 
                485                 490                 495     


Ala Glu Leu Lys Tyr Asp Asp Asn Arg Pro Asn Arg Val Cys Leu His 
            500                 505                 510         


Cys Tyr Ala Phe Leu Thr Gly Asn Val Leu Pro Glu Ala Lys Glu Asp 
        515                 520                 525             


Lys Arg Arg Gly Ile Leu Glu Lys Gly Ser Ser Ala Thr Pro Asp Gln 
    530                 535                 540                 


Ser Leu Met Cys Ser Phe Leu Gln Leu Ile Gly Asp Lys Trp Gly Lys 
545                 550                 555                 560 


Ser Gly Pro Arg Gly Trp Cys Val Ile Pro Arg Asp Asp Pro Leu Val 
                565                 570                 575     


Leu Tyr Val Tyr Ala Ala Pro Gln Asp Met Arg Ala His Thr Ser Ile 
            580                 585                 590         


Pro Leu Leu Gly Tyr Gln Val Thr Val Gly Pro Gln Gly Asp Pro Arg 
        595                 600                 605             


Val Phe Gln Leu Gln Gln Ser Gly Gln Leu Tyr Thr Phe Lys Ala Glu 
    610                 615                 620                 


Thr Glu Glu Leu Lys Gly Arg Trp Val Lys Ala Met Glu Arg Ala Ala 
625                 630                 635                 640 


Ser Gly Trp Ser Pro Ser Trp Pro Asn Asp Gly Asp Leu Ser Asp 
                645                 650                 655 


<210>  305
<211>  1872
<212>  DNA
<213>  Homo sapiens

<400>  305
atgaaacagc ccaacaggaa aaggaagctt aatatggatt ccaaagagcg tttggatcag       60

gacggacgct tggagcaagc tgaagaggaa aagaagccca aggatagcac aacccctttg      120

agtcacgtcc cttcagcggc tgcacaggga gcatggtctt gggagtggta cttgaaagaa      180

cagaaggctg tcgcagcacc tgttgagctg ttttccaagg atcagtcctt tccagagcat      240

gaaaatggtt ttcagattgg aatgagatta gaaggcattg atccccgaca tccatcggta      300

ttctgtgtgc tttctgtagc ggaggtttgt ggttaccgtc taagacttca ttttgatggt      360

tatttaagtt gctatgattt ttggaccaat gctggttccc ctgacattca tccagtagga      420

tggtgtgaaa agaccaaaca tgaactgcac atccctaagg gttatagaaa agataaattt      480

gtttggatgg attacttgaa ggcctgcaaa ttgcaaaatg ctccaaagaa attattcaga      540

aacagaagtc ctaatgggcc aatgtctaaa gaatttcagg ttggaatgaa gctggaggcc      600

gtggacagga agaacccttc cttggtgtgt gtggcgacca tagcagatat tgttgaagat      660

cgcttactag tgcattttga caactgggat gatagttacg attactggtg cgatgttaat      720

agcccttatg tccagccagt tggttggtgt caggagaatg gaagaactct gatagcaccc      780

caaggttatc ccaatccaga aaatttttcc tggacagaat acctggaagc tactcaaacc      840

aatgcagttc ctgccaaagt ttttaaaatg aggttgcctc atggttttct gccaaatatg      900

aaacttgaag ttgtggataa acggaacccc aggttaattc gtgttgctac gattgtagat      960

gttgatgacc aaagagtaaa ggttcatttt gatggttggg accataagta tgactactgg     1020

gtggaggcag acagccctga tatccacccg atcggatggt gtgatgtcac agggcatcca     1080

ctggaagtgc cacagcgaac gaatgacctg aagatccttc caggtcaagc tgtctgtcct     1140

actcccgggt gccgaggaat aggccatatc cgtggtccac gttattcggg acatcacagt     1200

gcttttggct gcccgtattc agacatgaac ttgaaaaagg aggcaacact tcacgatcgt     1260

ttgagagaac aaacacaggc aaatttggaa tcagactctt cacattcaaa atcaaaaagc     1320

ctctgtagtt tgaacttcaa tggaaaacat gaaaaggtga acagtcagcc cagacttgta     1380

cagcaggcaa agtgtttgaa aatcaaagga aaagaagata ttgacttgga taatctcttc     1440

agagtgcttg tgctgcatcc cagaggtttg gaatactcgg tggagcaggc gcagcaggtg     1500

cttcaccagt cagtgtccat gtccacggtg tcagcccacc cttttcggga ccttcccctc     1560

ggcagggagc aacactgcaa gttgcttcca ggcgtggctg acatccgggc cagccaagtg     1620

gcacgttgga ctgtggatga ggtggctgag tttgtacagt ctcttctggg ctgtgaagag     1680

catgccaagt gctttaagaa agagcagatc gatggcaaag ccttcctgct tctgacacag     1740

acggacattg tcaaagtgat gaagatcaaa ctgggcccag cactgaagat ttacaactct     1800

atcctgatgt tcaggcattc ccaggaactc cctgaagaag atattgcctc aggccaagaa     1860

gtcaggggat ga                                                         1872


<210>  306
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Lys Gln Pro Asn Arg Lys Arg Lys Leu Asn Met Asp Ser Lys Glu 
1               5                   10                  15      


Arg Leu Asp Gln Asp Gly Arg Leu Glu Gln Ala Glu Glu Glu Lys Lys 
            20                  25                  30          


Pro Lys Asp Ser Thr Thr Pro Leu Ser His Val Pro Ser Ala Ala Ala 
        35                  40                  45              


Gln Gly Ala Trp Ser Trp Glu Trp Tyr Leu Lys Glu Gln Lys Ala Val 
    50                  55                  60                  


Ala Ala Pro Val Glu Leu Phe Ser Lys Asp Gln Ser Phe Pro Glu His 
65                  70                  75                  80  


Glu Asn Gly Phe Gln Ile Gly Met Arg Leu Glu Gly Ile Asp Pro Arg 
                85                  90                  95      


His Pro Ser Val Phe Cys Val Leu Ser Val Ala Glu Val Cys Gly Tyr 
            100                 105                 110         


Arg Leu Arg Leu His Phe Asp Gly Tyr Leu Ser Cys Tyr Asp Phe Trp 
        115                 120                 125             


Thr Asn Ala Gly Ser Pro Asp Ile His Pro Val Gly Trp Cys Glu Lys 
    130                 135                 140                 


Thr Lys His Glu Leu His Ile Pro Lys Gly Tyr Arg Lys Asp Lys Phe 
145                 150                 155                 160 


Val Trp Met Asp Tyr Leu Lys Ala Cys Lys Leu Gln Asn Ala Pro Lys 
                165                 170                 175     


Lys Leu Phe Arg Asn Arg Ser Pro Asn Gly Pro Met Ser Lys Glu Phe 
            180                 185                 190         


Gln Val Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro Ser Leu 
        195                 200                 205             


Val Cys Val Ala Thr Ile Ala Asp Ile Val Glu Asp Arg Leu Leu Val 
    210                 215                 220                 


His Phe Asp Asn Trp Asp Asp Ser Tyr Asp Tyr Trp Cys Asp Val Asn 
225                 230                 235                 240 


Ser Pro Tyr Val Gln Pro Val Gly Trp Cys Gln Glu Asn Gly Arg Thr 
                245                 250                 255     


Leu Ile Ala Pro Gln Gly Tyr Pro Asn Pro Glu Asn Phe Ser Trp Thr 
            260                 265                 270         


Glu Tyr Leu Glu Ala Thr Gln Thr Asn Ala Val Pro Ala Lys Val Phe 
        275                 280                 285             


Lys Met Arg Leu Pro His Gly Phe Leu Pro Asn Met Lys Leu Glu Val 
    290                 295                 300                 


Val Asp Lys Arg Asn Pro Arg Leu Ile Arg Val Ala Thr Ile Val Asp 
305                 310                 315                 320 


Val Asp Asp Gln Arg Val Lys Val His Phe Asp Gly Trp Asp His Lys 
                325                 330                 335     


Tyr Asp Tyr Trp Val Glu Ala Asp Ser Pro Asp Ile His Pro Ile Gly 
            340                 345                 350         


Trp Cys Asp Val Thr Gly His Pro Leu Glu Val Pro Gln Arg Thr Asn 
        355                 360                 365             


Asp Leu Lys Ile Leu Pro Gly Gln Ala Val Cys Pro Thr Pro Gly Cys 
    370                 375                 380                 


Arg Gly Ile Gly His Ile Arg Gly Pro Arg Tyr Ser Gly His His Ser 
385                 390                 395                 400 


Ala Phe Gly Cys Pro Tyr Ser Asp Met Asn Leu Lys Lys Glu Ala Thr 
                405                 410                 415     


Leu His Asp Arg Leu Arg Glu Gln Thr Gln Ala Asn Leu Glu Ser Asp 
            420                 425                 430         


Ser Ser His Ser Lys Ser Lys Ser Leu Cys Ser Leu Asn Phe Asn Gly 
        435                 440                 445             


Lys His Glu Lys Val Asn Ser Gln Pro Arg Leu Val Gln Gln Ala Lys 
    450                 455                 460                 


Cys Leu Lys Ile Lys Gly Lys Glu Asp Ile Asp Leu Asp Asn Leu Phe 
465                 470                 475                 480 


Arg Val Leu Val Leu His Pro Arg Gly Leu Glu Tyr Ser Val Glu Gln 
                485                 490                 495     


Ala Gln Gln Val Leu His Gln Ser Val Ser Met Ser Thr Val Ser Ala 
            500                 505                 510         


His Pro Phe Arg Asp Leu Pro Leu Gly Arg Glu Gln His Cys Lys Leu 
        515                 520                 525             


Leu Pro Gly Val Ala Asp Ile Arg Ala Ser Gln Val Ala Arg Trp Thr 
    530                 535                 540                 


Val Asp Glu Val Ala Glu Phe Val Gln Ser Leu Leu Gly Cys Glu Glu 
545                 550                 555                 560 


His Ala Lys Cys Phe Lys Lys Glu Gln Ile Asp Gly Lys Ala Phe Leu 
                565                 570                 575     


Leu Leu Thr Gln Thr Asp Ile Val Lys Val Met Lys Ile Lys Leu Gly 
            580                 585                 590         


Pro Ala Leu Lys Ile Tyr Asn Ser Ile Leu Met Phe Arg His Ser Gln 
        595                 600                 605             


Glu Leu Pro Glu Glu Asp Ile Ala Ser Gly Gln Glu Val Arg Gly 
    610                 615                 620             


<210>  307
<211>  4026
<212>  DNA
<213>  Homo sapiens

<400>  307
atgtggagac ggaaacatcc gaggacatcc ggaggaaccc ggggagttct gagtggtaat       60

cgaggggtag agtatggcag tgggcggggt catctcggta cgttcgaagg gcgttggcgg      120

aaattaccga agatgcccga agccgtcggg acggacccga gtacctcacg caagatggcg      180

gagctggagg aggtgactct ggacgggaag cctcttcagg cgctgcgggt gaccgacctg      240

aaggccgcac tggagcagcg aggcctagcc aagagcgggc agaagagtgc cctggtcaag      300

cggctcaaag gggctctaat gctagaaaat ttacagaaac actcaacacc ccatgctgca      360

ttccagccaa attcccagat tggtgaggaa atgagccaga acagtttcat aaaacagtat      420

ctggaaaagc agcaggagct acttaggcag cgtctggaac gtgaagctcg agaagctgca      480

gaacttgaag aagcttcagc tgagtcggag gacgagatga tccatcctga gggagtggct      540

tccctgctgc ctcctgactt tcagagcagc ctggagagac cagagctgga gctcagcaga      600

cattcgccca gaaaaagctc ctcaatttct gaagagaaag gtgactctga tgatgagaaa      660

ccaaggaaag gagaaagacg atcatctagg gtcagacagg caagagcagc taaactgtct      720

gagggcagcc aacctgctga ggaggaagag gatcaagaaa caccttccag aaacctaagg      780

gtcagagcag atcgaaattt gaaaacagag gaggaagaag aggaggagga ggaggaggaa      840

gaagatgatg aagaagagga aggtgatgat gagggacaaa aatctaggga ggcaccaatc      900

ctgaaagagt ttaaggaaga aggggaagag atacctagag taaaaccaga ggagatgatg      960

gatgagagac ccaaaacaag atcccaggaa caggaggtgt tagagagagg agggagattt     1020

acaagatccc aggaagaggc tagaaaaagt catctggcca gacagcagca ggagaaggaa     1080

atgaaaacaa catctcccct tgaggaggaa gaaagagaaa taaaatcttc acaaggctta     1140

aaggaaaaat cgaagtctcc ttcccctcct cgactgactg aagatcgaaa gaaggcctca     1200

cttgtagcgc tgccagagca aactgccagc gaggaggaga ctcctccacc tttactaaca     1260

aaggaagcat cttctccacc acctcatcca cagctccata gcgaagaaga aatagagccc     1320

atggaaggcc cagcccccgc tgtcctcatt cagttatctc ctcctaatac agatgctgac     1380

accagggagc tattagtatc tcagcatact gtccagttgg taggaggcct gtctcctttg     1440

tcaagtcctt cagacaccaa agcagaatct ccagcagaga aagtgccaga ggagagtgtc     1500

ctgcctctgg ttcagaaaag cacactggct gactactcag cccagaagga tcttgaacct     1560

gagtcagaca gatctgctca gcccctccct ctaaaaattg aggaattagc actggccaaa     1620

ggaatcactg aagaatgtct gaaacagcca tctttggaac agaaggaagg cagaagagct     1680

tctcataccc ttctcccaag ccacagattg aaacagtcag ctgattcatc ctctagccgg     1740

tcctcctcat cttcctcctc cagttctaga tcaagatctc gctctcctga cagttcaggt     1800

tctcggtctc attcaccgct cagatccaag cagagagatg tagcccaggc acgtactcat     1860

gccaaccctc gtggtagacc caagatgggc tccagatcaa catcagagtc cagatcaagg     1920

tcacgttcac gttctcgttc agcatcaagc aacagcagaa aatctctgag ccctggagtc     1980

tccagggaca gcagcaccag ctatactgaa accaaagatc cctcttctgg tcaggaggtt     2040

gcaactccac cagtgccaca actgcaggtc tgtgagccaa aggagaggac ttccacctcc     2100

tcatcctctg tccaagcaag gcgtctgagt cagcctgaat cagctgaaaa gcatgtgacc     2160

cagaggttac agcctgagcg ggggagccca aagaagtgtg aagctgaaga ggcagagcca     2220

ccagctgcca cacagcccca aacctcagag actcagacct ctcatctgcc agaatcagaa     2280

agaattcatc acactgttga ggagaaggag gaagtgacca tggacacaag tgaaaacaga     2340

cctgaaaatg atgttccaga acctcccatg cctattgcag accaagtcag caatgatgac     2400

cgcccggagg gcagtgttga agatgaggag aagaaagaga gctcgctgcc caaatcattc     2460

aagaggaaga tctccgttgt ctcagctacc aagggggtgc cagctggaaa cagtgacaca     2520

gaggggggcc agcctggtcg gaaacgacgc tggggagcca gcacagccac cacacagaag     2580

aaaccttcca tcagtatcac cactgaatca ctaaagagcc tcatccccga catcaaaccc     2640

ctggcggggc aggaggctgt tgtggatctt catgctgatg actctcgcat ctctgaggat     2700

gagacagagc gtaatggcga tgatgggacc catgacaagg ggctgaaaat atgccggaca     2760

gtcactcagg tagtacctgc agagggccag gagaatgggc agagggaaga agaggaagaa     2820

gagaaggaac ctgaagcaga acctcctgta cctccccagg tgtcagtaga ggtggccttg     2880

cccccacctg cagagcatga agtaaagaaa gtgactttag gagatacctt aactcgacgt     2940

tccattagcc agcagaagtc cggagtttcc attaccattg atgacccagt ccgaactgcc     3000

caggtgccct ccccaccccg gggcaagatt agcaacattg tccatatctc caatttggtc     3060

cgtcctttca ctttaggcca gctaaaggag ttgttggggc gcacaggaac cttggtggaa     3120

gaggccttct ggattgacaa gatcaaatct cattgctttg taacgtactc aacagtagag     3180

gaagctgttg ccacccgcac agctctgcac ggggtcaaat ggccccagtc caatcccaaa     3240

ttcctttgtg ctgactatgc cgagcaagat gagctggatt atcaccgagg cctcttggtg     3300

gaccgtccct ctgaaactaa gacagaggag cagggaatac cacggcccct gcacccccca     3360

cccccacccc cggtccagcc accacagcac ccccgggcag agcagcggga gcaggaacgg     3420

gcagtgcggg aacagtgggc agaacgggaa cgggaaatgg agcggcggga gcggactcga     3480

tcagagcgtg aatgggatcg ggacaaagtt cgagaagggc cccgttcccg atcaaggtcc     3540

cgtgaccgcc gccgcaagga acgtgcgaag tctaaagaaa agaagagtga gaagaaagag     3600

aaagcccagg aggaaccacc tgccaagctg ctggatgacc ttttccgaaa gaccaaggca     3660

gctccctgca tctattggct cccactgact gacagccaga tcgttcagaa agaggcagag     3720

cgggccgaac gggccaagga gcgggagaag cggcgaaagg agcaagaaga agaagagcaa     3780

aaggagcggg agaaggaagc cgagcgggaa cggaaccgac agctggagcg agagaaacgt     3840

cgggagcaca gtcgggagag ggacagggag agagagagag aaagggagcg ggacaggggg     3900

gaccgagatc gggataggga aagggaccga gaacgaggca gggaaaggga tcgcagggac     3960

accaagcgcc acagcagaag ccggagtcgg agcacacctg tgcgggaccg gggtgggcgc     4020

cgctag                                                                4026


<210>  308
<211>  1341
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Glu Ala Ser Ala Glu Ser Glu Asp Glu Met Ile His Pro 
                165                 170                 175     


Glu Gly Val Ala Ser Leu Leu Pro Pro Asp Phe Gln Ser Ser Leu Glu 
            180                 185                 190         


Arg Pro Glu Leu Glu Leu Ser Arg His Ser Pro Arg Lys Ser Ser Ser 
        195                 200                 205             


Ile Ser Glu Glu Lys Gly Asp Ser Asp Asp Glu Lys Pro Arg Lys Gly 
    210                 215                 220                 


Glu Arg Arg Ser Ser Arg Val Arg Gln Ala Arg Ala Ala Lys Leu Ser 
225                 230                 235                 240 


Glu Gly Ser Gln Pro Ala Glu Glu Glu Glu Asp Gln Glu Thr Pro Ser 
                245                 250                 255     


Arg Asn Leu Arg Val Arg Ala Asp Arg Asn Leu Lys Thr Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Gly 
        275                 280                 285             


Asp Asp Glu Gly Gln Lys Ser Arg Glu Ala Pro Ile Leu Lys Glu Phe 
    290                 295                 300                 


Lys Glu Glu Gly Glu Glu Ile Pro Arg Val Lys Pro Glu Glu Met Met 
305                 310                 315                 320 


Asp Glu Arg Pro Lys Thr Arg Ser Gln Glu Gln Glu Val Leu Glu Arg 
                325                 330                 335     


Gly Gly Arg Phe Thr Arg Ser Gln Glu Glu Ala Arg Lys Ser His Leu 
            340                 345                 350         


Ala Arg Gln Gln Gln Glu Lys Glu Met Lys Thr Thr Ser Pro Leu Glu 
        355                 360                 365             


Glu Glu Glu Arg Glu Ile Lys Ser Ser Gln Gly Leu Lys Glu Lys Ser 
    370                 375                 380                 


Lys Ser Pro Ser Pro Pro Arg Leu Thr Glu Asp Arg Lys Lys Ala Ser 
385                 390                 395                 400 


Leu Val Ala Leu Pro Glu Gln Thr Ala Ser Glu Glu Glu Thr Pro Pro 
                405                 410                 415     


Pro Leu Leu Thr Lys Glu Ala Ser Ser Pro Pro Pro His Pro Gln Leu 
            420                 425                 430         


His Ser Glu Glu Glu Ile Glu Pro Met Glu Gly Pro Ala Pro Pro Val 
        435                 440                 445             


Leu Ile Gln Leu Ser Pro Pro Asn Thr Asp Ala Asp Thr Arg Glu Leu 
    450                 455                 460                 


Leu Val Ser Gln His Thr Val Gln Leu Val Gly Gly Leu Ser Pro Leu 
465                 470                 475                 480 


Ser Ser Pro Ser Asp Thr Lys Ala Glu Ser Pro Ala Glu Lys Val Pro 
                485                 490                 495     


Glu Glu Ser Val Leu Pro Leu Val Gln Lys Ser Thr Leu Ala Asp Tyr 
            500                 505                 510         


Ser Ala Gln Lys Asp Leu Glu Pro Glu Ser Asp Arg Ser Ala Gln Pro 
        515                 520                 525             


Leu Pro Leu Lys Ile Glu Glu Leu Ala Leu Ala Lys Gly Ile Thr Glu 
    530                 535                 540                 


Glu Cys Leu Lys Gln Pro Ser Leu Glu Gln Lys Glu Gly Arg Arg Ala 
545                 550                 555                 560 


Ser His Thr Leu Leu Pro Ser His Arg Leu Lys Gln Ser Ala Asp Ser 
                565                 570                 575     


Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Asp Ser Ser Gly Ser Arg Ser His Ser Pro Leu Arg 
        595                 600                 605             


Ser Lys Gln Arg Asp Val Ala Gln Ala Arg Thr His Ala Asn Pro Arg 
    610                 615                 620                 


Gly Arg Pro Lys Met Gly Ser Arg Ser Thr Ser Glu Ser Arg Ser Arg 
625                 630                 635                 640 


Ser Arg Ser Arg Ser Arg Ser Ala Ser Ser Asn Ser Arg Lys Ser Leu 
                645                 650                 655     


Ser Pro Gly Val Ser Arg Asp Ser Ser Thr Ser Tyr Thr Glu Thr Lys 
            660                 665                 670         


Asp Pro Ser Ser Gly Gln Glu Val Ala Thr Pro Pro Val Pro Gln Leu 
        675                 680                 685             


Gln Val Cys Glu Pro Lys Glu Arg Thr Ser Thr Ser Ser Ser Ser Val 
    690                 695                 700                 


Gln Ala Arg Arg Leu Ser Gln Pro Glu Ser Ala Glu Lys His Val Thr 
705                 710                 715                 720 


Gln Arg Leu Gln Pro Glu Arg Gly Ser Pro Lys Lys Cys Glu Ala Glu 
                725                 730                 735     


Glu Ala Glu Pro Pro Ala Ala Thr Gln Pro Gln Thr Ser Glu Thr Gln 
            740                 745                 750         


Thr Ser His Leu Pro Glu Ser Glu Arg Ile His His Thr Val Glu Glu 
        755                 760                 765             


Lys Glu Glu Val Thr Met Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp 
    770                 775                 780                 


Val Pro Glu Pro Pro Met Pro Ile Ala Asp Gln Val Ser Asn Asp Asp 
785                 790                 795                 800 


Arg Pro Glu Gly Ser Val Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu 
                805                 810                 815     


Pro Lys Ser Phe Lys Arg Lys Ile Ser Val Val Ser Ala Thr Lys Gly 
            820                 825                 830         


Val Pro Ala Gly Asn Ser Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys 
        835                 840                 845             


Arg Arg Trp Gly Ala Ser Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile 
    850                 855                 860                 


Ser Ile Thr Thr Glu Ser Leu Lys Ser Leu Ile Pro Asp Ile Lys Pro 
865                 870                 875                 880 


Leu Ala Gly Gln Glu Ala Val Val Asp Leu His Ala Asp Asp Ser Arg 
                885                 890                 895     


Ile Ser Glu Asp Glu Thr Glu Arg Asn Gly Asp Asp Gly Thr His Asp 
            900                 905                 910         


Lys Gly Leu Lys Ile Cys Arg Thr Val Thr Gln Val Val Pro Ala Glu 
        915                 920                 925             


Gly Gln Glu Asn Gly Gln Arg Glu Glu Glu Glu Glu Glu Lys Glu Pro 
    930                 935                 940                 


Glu Ala Glu Pro Pro Val Pro Pro Gln Val Ser Val Glu Val Ala Leu 
945                 950                 955                 960 


Pro Pro Pro Ala Glu His Glu Val Lys Lys Val Thr Leu Gly Asp Thr 
                965                 970                 975     


Leu Thr Arg Arg Ser Ile Ser Gln Gln Lys Ser Gly Val Ser Ile Thr 
            980                 985                 990         


Ile Asp Asp Pro Val Arg Thr Ala  Gln Val Pro Ser Pro  Pro Arg Gly 
        995                 1000                 1005             


Lys Ile  Ser Asn Ile Val His  Ile Ser Asn Leu Val  Arg Pro Phe 
    1010                 1015                 1020             


Thr Leu  Gly Gln Leu Lys Glu  Leu Leu Gly Arg Thr  Gly Thr Leu 
    1025                 1030                 1035             


Val Glu  Glu Ala Phe Trp Ile  Asp Lys Ile Lys Ser  His Cys Phe 
    1040                 1045                 1050             


Val Thr  Tyr Ser Thr Val Glu  Glu Ala Val Ala Thr  Arg Thr Ala 
    1055                 1060                 1065             


Leu His  Gly Val Lys Trp Pro  Gln Ser Asn Pro Lys  Phe Leu Cys 
    1070                 1075                 1080             


Ala Asp  Tyr Ala Glu Gln Asp  Glu Leu Asp Tyr His  Arg Gly Leu 
    1085                 1090                 1095             


Leu Val  Asp Arg Pro Ser Glu  Thr Lys Thr Glu Glu  Gln Gly Ile 
    1100                 1105                 1110             


Pro Arg  Pro Leu His Pro Pro  Pro Pro Pro Pro Val  Gln Pro Pro 
    1115                 1120                 1125             


Gln His  Pro Arg Ala Glu Gln  Arg Glu Gln Glu Arg  Ala Val Arg 
    1130                 1135                 1140             


Glu Gln  Trp Ala Glu Arg Glu  Arg Glu Met Glu Arg  Arg Glu Arg 
    1145                 1150                 1155             


Thr Arg  Ser Glu Arg Glu Trp  Asp Arg Asp Lys Val  Arg Glu Gly 
    1160                 1165                 1170             


Pro Arg  Ser Arg Ser Arg Ser  Arg Asp Arg Arg Arg  Lys Glu Arg 
    1175                 1180                 1185             


Ala Lys  Ser Lys Glu Lys Lys  Ser Glu Lys Lys Glu  Lys Ala Gln 
    1190                 1195                 1200             


Glu Glu  Pro Pro Ala Lys Leu  Leu Asp Asp Leu Phe  Arg Lys Thr 
    1205                 1210                 1215             


Lys Ala  Ala Pro Cys Ile Tyr  Trp Leu Pro Leu Thr  Asp Ser Gln 
    1220                 1225                 1230             


Ile Val  Gln Lys Glu Ala Glu  Arg Ala Glu Arg Ala  Lys Glu Arg 
    1235                 1240                 1245             


Glu Lys  Arg Arg Lys Glu Gln  Glu Glu Glu Glu Gln  Lys Glu Arg 
    1250                 1255                 1260             


Glu Lys  Glu Ala Glu Arg Glu  Arg Asn Arg Gln Leu  Glu Arg Glu 
    1265                 1270                 1275             


Lys Arg  Arg Glu His Ser Arg  Glu Arg Asp Arg Glu  Arg Glu Arg 
    1280                 1285                 1290             


Glu Arg  Glu Arg Asp Arg Gly  Asp Arg Asp Arg Asp  Arg Glu Arg 
    1295                 1300                 1305             


Asp Arg  Glu Arg Gly Arg Glu  Arg Asp Arg Arg Asp  Thr Lys Arg 
    1310                 1315                 1320             


His Ser  Arg Ser Arg Ser Arg  Ser Thr Pro Val Arg  Asp Arg Gly 
    1325                 1330                 1335             


Gly Arg  Arg 
    1340     


<210>  309
<211>  2931
<212>  DNA
<213>  Homo sapiens

<400>  309
atgagaggcg ctcgcggcgc ctgggatttt ctctgcgttc tgctcctact gcttcgcgtc       60

cagacaggct cttctcaacc atctgtgagt ccaggggaac cgtctccacc atccatccat      120

ccaggaaaat cagacttaat agtccgcgtg ggcgacgaga ttaggctgtt atgcactgat      180

ccgggctttg tcaaatggac ttttgagatc ctggatgaaa cgaatgagaa taagcagaat      240

gaatggatca cggaaaaggc agaagccacc aacaccggca aatacacgtg caccaacaaa      300

cacggcttaa gcaattccat ttatgtgttt gttagagatc ctgccaagct tttccttgtt      360

gaccgctcct tgtatgggaa agaagacaac gacacgctgg tccgctgtcc tctcacagac      420

ccagaagtga ccaattattc cctcaagggg tgccagggga agcctcttcc caaggacttg      480

aggtttattc ctgaccccaa ggcgggcatc atgatcaaaa gtgtgaaacg cgcctaccat      540

cggctctgtc tgcattgttc tgtggaccag gagggcaagt cagtgctgtc ggaaaaattc      600

atcctgaaag tgaggccagc cttcaaagct gtgcctgttg tgtctgtgtc caaagcaagc      660

tatcttctta gggaagggga agaattcaca gtgacgtgca caataaaaga tgtgtctagt      720

tctgtgtact caacgtggaa aagagaaaac agtcagacta aactacagga gaaatataat      780

agctggcatc acggtgactt caattatgaa cgtcaggcaa cgttgactat cagttcagcg      840

agagttaatg attctggagt gttcatgtgt tatgccaata atacttttgg atcagcaaat      900

gtcacaacaa ccttggaagt agtagataaa ggattcatta atatcttccc catgataaac      960

actacagtat ttgtaaacga tggagaaaat gtagatttga ttgttgaata tgaagcattc     1020

cccaaacctg aacaccagca gtggatctat atgaacagaa ccttcactga taaatgggaa     1080

gattatccca agtctgagaa tgaaagtaat atcagatacg taagtgaact tcatctaacg     1140

agattaaaag gcaccgaagg aggcacttac acattcctag tgtccaattc tgacgtcaat     1200

gctgccatag catttaatgt ttatgtgaat acaaaaccag aaatcctgac ttacgacagg     1260

ctcgtgaatg gcatgctcca atgtgtggca gcaggattcc cagagcccac aatagattgg     1320

tatttttgtc caggaactga gcagagatgc tctgcttctg tactgccagt ggatgtgcag     1380

acactaaact catctgggcc accgtttgga aagctagtgg ttcagagttc tatagattct     1440

agtgcattca agcacaatgg cacggttgaa tgtaaggctt acaacgatgt gggcaagact     1500

tctgcctatt ttaactttgc atttaaaggt aacaacaaag agcaaatcca tccccacacc     1560

ctgttcactc ctttgctgat tggtttcgta atcgtagctg gcatgatgtg cattattgtg     1620

atgattctga cctacaaata tttacagaaa cccatgtatg aagtacagtg gaaggttgtt     1680

gaggagataa atggaaacaa ttatgtttac atagacccaa cacaacttcc ttatgatcac     1740

aaatgggagt ttcccagaaa caggctgagt tttgggaaaa ccctgggtgc tggagctttc     1800

gggaaggttg ttgaggcaac tgcttatggc ttaattaagt cagatgcggc catgactgtc     1860

gctgtaaaga tgctcaagcc gagtgcccat ttgacagaac gggaagccct catgtctgaa     1920

ctcaaagtcc tgagttacct tggtaatcac atgaatattg tgaatctact tggagcctgc     1980

accattggag ggcccaccct ggtcattaca gaatattgtt gctatggtga tcttttgaat     2040

tttttgagaa gaaaacgtga ttcatttatt tgttcaaagc aggaagatca tgcagaagct     2100

gcactttata agaatcttct gcattcaaag gagtcttcct gcagcgatag tactaatgag     2160

tacatggaca tgaaacctgg agtttcttat gttgtcccaa ccaaggccga caaaaggaga     2220

tctgtgagaa taggctcata catagaaaga gatgtgactc ccgccatcat ggaggatgac     2280

gagttggccc tagacttaga agacttgctg agcttttctt accaggtggc aaagggcatg     2340

gctttcctcg cctccaagaa ttgtattcac agagacttgg cagccagaaa tatcctcctt     2400

actcatggtc ggatcacaaa gatttgtgat tttggtctag ccagagacat caagaatgat     2460

tctaattatg tggttaaagg aaacgctcga ctacctgtga agtggatggc acctgaaagc     2520

attttcaact gtgtatacac gtttgaaagt gacgtctggt cctatgggat ttttctttgg     2580

gagctgttct ctttaggaag cagcccctat cctggaatgc cggtcgattc taagttctac     2640

aagatgatca aggaaggctt ccggatgctc agccctgaac acgcacctgc tgaaatgtat     2700

gacataatga agacttgctg ggatgcagat cccctaaaaa gaccaacatt caagcaaatt     2760

gttcagctaa ttgagaagca gatttcagag agcaccaatc atatttactc caacttagca     2820

aactgcagcc ccaaccgaca gaagcccgtg gtagaccatt ctgtgcggat caattctgtc     2880

ggcagcaccg cttcctcctc ccagcctctg cttgtgcacg acgatgtctg a              2931


<210>  310
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  311
<211>  3213
<212>  DNA
<213>  Homo sapiens

<400>  311
atgggagctg cgcggggatc cccggccaga ccccgccggt tgcctctgct cagcgtcctg       60

ctgctgccgc tgctgggcgg tacccagaca gccattgtct tcatcaagca gccgtcctcc      120

caggatgcac tgcaggggcg ccgggcgctg cttcgctgtg aggttgaggc tccgggcccg      180

gtacatgtgt actggctgct cgatggggcc cctgtccagg acacggagcg gcgtttcgcc      240

cagggcagca gcctgagctt tgcagctgtg gaccggctgc aggactctgg caccttccag      300

tgtgtggctc gggatgatgt cactggagaa gaagcccgca gtgccaacgc ctccttcaac      360

atcaaatgga ttgaggcagg tcctgtggtc ctgaagcatc cagcctcgga agctgagatc      420

cagccacaga cccaggtcac acttcgttgc cacattgatg ggcaccctcg gcccacctac      480

caatggttcc gagatgggac ccccctttct gatggtcaga gcaaccacac agtcagcagc      540

aaggagcgga acctgacgct ccggccagct ggtcctgagc atagtgggct gtattcctgc      600

tgcgcccaca gtgcttttgg ccaggcttgc agcagccaga acttcacctt gagcattgct      660

gatgaaagct ttgccagggt ggtgctggca ccccaggacg tggtagtagc gaggtatgag      720

gaggccatgt tccattgcca gttctcagcc cagccacccc cgagcctgca gtggctcttt      780

gaggatgaga ctcccatcac taaccgcagt cgccccccac acctccgcag agccacagtg      840

tttgccaacg ggtctctgct gctgacccag gtccggccac gcaatgcagg gatctaccgc      900

tgcattggcc aggggcagag gggcccaccc atcatcctgg aagccacact tcacctagca      960

gagattgaag acatgccgct atttgagcca cgggtgttta cagctggcag cgaggagcgt     1020

gtgacctgcc ttccccccaa gggtctgcca gagcccagcg tgtggtggga gcacgcggga     1080

gtccggctgc ccacccatgg cagggtctac cagaagggcc acgagctggt gttggccaat     1140

attgctgaaa gtgatgctgg tgtctacacc tgccacgcgg ccaacctggc tggtcagcgg     1200

agacaggatg tcaacatcac tgtggccact gtgccctcct ggctgaagaa gccccaagac     1260

agccagctgg aggagggcaa acccggctac ttggattgcc tgacccaggc cacaccaaaa     1320

cctacagttg tctggtacag aaaccagatg ctcatctcag aggactcacg gttcgaggtc     1380

ttcaagaatg ggaccttgcg catcaacagc gtggaggtgt atgatgggac atggtaccgt     1440

tgtatgagca gcaccccagc cggcagcatc gaggcgcaag cccgtgtcca agtgctggaa     1500

aagctcaagt tcacaccacc accccagcca cagcagtgca tggagtttga caaggaggcc     1560

acggtgccct gttcagccac aggccgagag aagcccacta ttaagtggga acgggcagat     1620

gggagcagcc tcccagagtg ggtgacagac aacgctggga ccctgcattt tgcccgggtg     1680

actcgagatg acgctggcaa ctacacttgc attgcctcca acgggccgca gggccagatt     1740

cgtgcccatg tccagctcac tgtggcagtt tttatcacct tcaaagtgga accagagcgt     1800

acgactgtgt accagggcca cacagcccta ctgcagtgcg aggcccaggg ggaccccaag     1860

ccgctgattc agtggaaagg caaggaccgc atcctggacc ccaccaagct gggacccagg     1920

atgcacatct tccagaatgg ctccctggtg atccatgacg tggcccctga ggactcaggc     1980

cgctacacct gcattgcagg caacagctgc aacatcaagc acacggaggc ccccctctat     2040

gtcgtggaca agcctgtgcc ggaggagtcg gagggccctg gcagccctcc cccctacaag     2100

atgatccaga ccattgggtt gtcggtgggt gccgctgtgg cctacatcat tgccgtgctg     2160

ggcctcatgt tctactgcaa gaagcgctgc aaagccaagc ggctgcagaa gcagcccgag     2220

ggcgaggagc cagagatgga atgcctcaac ggtgggcctt tgcagaacgg gcagccctca     2280

gcagagatcc aagaagaagt ggccttgacc agcttgggct ccggccccgc ggccaccaac     2340

aaacgccaca gcacaagtga taagatgcac ttcccacggt ctagcctgca gcccatcacc     2400

acgctgggga agagtgagtt tggggaggtg ttcctggcaa aggctcaggg cttggaggag     2460

ggagtggcag agaccctggt acttgtgaag agcctgcaga gcaaggatga gcagcagcag     2520

ctggacttcc ggagggagtt ggagatgttt gggaagctga accacgccaa cgtggtgcgg     2580

ctcctggggc tgtgccggga ggctgagccc cactacatgg tgctggaata tgtggatctg     2640

ggagacctca agcagttcct gaggatttcc aagagcaagg atgaaaaatt gaagtcacag     2700

cccctcagca ccaagcagaa ggtggcccta tgcacccagg tagccctggg catggagcac     2760

ctgtccaaca accgctttgt gcataaggac ttggctgcgc gtaactgcct ggtcagtgcc     2820

cagagacaag tgaaggtgtc tgccctgggc ctcagcaagg atgtgtacaa cagtgagtac     2880

taccacttcc gccaggcctg ggtgccgctg cgctggatgt cccccgaggc catcctggag     2940

ggtgacttct ctaccaagtc tgatgtctgg gccttcggtg tgctgatgtg ggaagtgttt     3000

acacatggag agatgcccca tggtgggcag gcagatgatg aagtactggc agatttgcag     3060

gctgggaagg ctagacttcc tcagcccgag ggctgccctt ccaaactcta tcggctgatg     3120

cagcgctgct gggccctcag ccccaaggac cggccctcct tcagtgagat tgccagcgcc     3180

ctgggagaca gcaccgtgga cagcaagccg tga                                  3213


<210>  312
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Glu Lys Leu Lys Phe Thr Pro Pro Pro Gln Pro Gln Gln 
            500                 505                 510         


Cys Met Glu Phe Asp Lys Glu Ala Thr Val Pro Cys Ser Ala Thr Gly 
        515                 520                 525             


Arg Glu Lys Pro Thr Ile Lys Trp Glu Arg Ala Asp Gly Ser Ser Leu 
    530                 535                 540                 


Pro Glu Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val 
545                 550                 555                 560 


Thr Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro 
                565                 570                 575     


Gln Gly Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile 
            580                 585                 590         


Thr Phe Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr 
        595                 600                 605             


Ala Leu Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln 
    610                 615                 620                 


Trp Lys Gly Lys Asp Arg Ile Leu Asp Pro Thr Lys Leu Gly Pro Arg 
625                 630                 635                 640 


Met His Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala Pro 
                645                 650                 655     


Glu Asp Ser Gly Arg Tyr Thr Cys Ile Ala Gly Asn Ser Cys Asn Ile 
            660                 665                 670         


Lys His Thr Glu Ala Pro Leu Tyr Val Val Asp Lys Pro Val Pro Glu 
        675                 680                 685             


Glu Ser Glu Gly Pro Gly Ser Pro Pro Pro Tyr Lys Met Ile Gln Thr 
    690                 695                 700                 


Ile Gly Leu Ser Val Gly Ala Ala Val Ala Tyr Ile Ile Ala Val Leu 
705                 710                 715                 720 


Gly Leu Met Phe Tyr Cys Lys Lys Arg Cys Lys Ala Lys Arg Leu Gln 
                725                 730                 735     


Lys Gln Pro Glu Gly Glu Glu Pro Glu Met Glu Cys Leu Asn Gly Gly 
            740                 745                 750         


Pro Leu Gln Asn Gly Gln Pro Ser Ala Glu Ile Gln Glu Glu Val Ala 
        755                 760                 765             


Leu Thr Ser Leu Gly Ser Gly Pro Ala Ala Thr Asn Lys Arg His Ser 
    770                 775                 780                 


Thr Ser Asp Lys Met His Phe Pro Arg Ser Ser Leu Gln Pro Ile Thr 
785                 790                 795                 800 


Thr Leu Gly Lys Ser Glu Phe Gly Glu Val Phe Leu Ala Lys Ala Gln 
                805                 810                 815     


Gly Leu Glu Glu Gly Val Ala Glu Thr Leu Val Leu Val Lys Ser Leu 
            820                 825                 830         


Gln Ser Lys Asp Glu Gln Gln Gln Leu Asp Phe Arg Arg Glu Leu Glu 
        835                 840                 845             


Met Phe Gly Lys Leu Asn His Ala Asn Val Val Arg Leu Leu Gly Leu 
    850                 855                 860                 


Cys Arg Glu Ala Glu Pro His Tyr Met Val Leu Glu Tyr Val Asp Leu 
865                 870                 875                 880 


Gly Asp Leu Lys Gln Phe Leu Arg Ile Ser Lys Ser Lys Asp Glu Lys 
                885                 890                 895     


Leu Lys Ser Gln Pro Leu Ser Thr Lys Gln Lys Val Ala Leu Cys Thr 
            900                 905                 910         


Gln Val Ala Leu Gly Met Glu His Leu Ser Asn Asn Arg Phe Val His 
        915                 920                 925             


Lys Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Ala Gln Arg Gln Val 
    930                 935                 940                 


Lys Val Ser Ala Leu Gly Leu Ser Lys Asp Val Tyr Asn Ser Glu Tyr 
945                 950                 955                 960 


Tyr His Phe Arg Gln Ala Trp Val Pro Leu Arg Trp Met Ser Pro Glu 
                965                 970                 975     


Ala Ile Leu Glu Gly Asp Phe Ser Thr Lys Ser Asp Val Trp Ala Phe 
            980                 985                 990         


Gly Val Leu Met Trp Glu Val Phe  Thr His Gly Glu Met  Pro His Gly 
        995                 1000                 1005             


Gly Gln  Ala Asp Asp Glu Val  Leu Ala Asp Leu Gln  Ala Gly Lys 
    1010                 1015                 1020             


Ala Arg  Leu Pro Gln Pro Glu  Gly Cys Pro Ser Lys  Leu Tyr Arg 
    1025                 1030                 1035             


Leu Met  Gln Arg Cys Trp Ala  Leu Ser Pro Lys Asp  Arg Pro Ser 
    1040                 1045                 1050             


Phe Ser  Glu Ile Ala Ser Ala  Leu Gly Asp Ser Thr  Val Asp Ser 
    1055                 1060                 1065             


Lys Pro  
    1070 


<210>  313
<211>  1905
<212>  DNA
<213>  Homo sapiens

<400>  313
atggacaacg ccgttgacgg actggacaaa gcttctatag caaactcaga tggccccaca       60

gcaggttccc aaacacctcc cttcaaaaga aaggggaaac tatccaccat tggtaaaatc      120

tttaagcctt ggaaatggag gaaaaagaag accagcgaca aatttagaga aacctcggca      180

gtattagaaa ggaagatatc cacacgacaa agtagagagg agctgataag aaggggagtg      240

cttaaggaat tgcctgatca agatggagat gtaacagtta actttgaaaa ttcaaacggg      300

cacatgatac ccatcggaga ggaatctacc cgagaggaaa atgtagtaaa gtctgaagaa      360

ggtaatggct ctgtatctga aaaaacacca cctctggagg aacaggcaga agataagaaa      420

gagaacactg aaaaccactc tgaaacaccg gcagctcctg ctctacctcc ttctgctcct      480

cctaagccta gacccaaacc taaacccaaa aaatcacctg tgcctccgaa aggggccact      540

gctggggcca gccacaaagg tgatgaagtg cctcccatta aaaaaaatac caaggctcct      600

ggtaagcagg cccccgtccc tccacccaag ccagcaagcc gaaacacgac ccgagaggct      660

gctggctcct ctcattcaaa aaaaacaact ggctctaaag catcagcttc gccatccact      720

tcatccacct catctcgtcc caaagcttca aaggagacag tttctagcaa agcagggaca      780

gtggggacca ccaagggcaa gagaaaaact gacaagcagc caataacttc tcacctgtcc      840

tcagacacaa caacttctgg cacatccgac ctgaaaggag agcctgcaga gaccagagtg      900

gagagtttca aactcgaaca gactgtccct ggagctgagg agcagaacac aggcaaattc      960

aagtccatgg tccctccacc ccctgtggct ccagcacctt ctcctctggc cccccctctc     1020

cctcttgagg atcagtgcat tactgcctca gacactccag ttgtcctcgt cagcgttgga     1080

gctgacctgc ccgtctctgc cttagaccca agtcagcttc tttgggctga agagccgacg     1140

aacagaacca ctctctactc aggcactggc ttaagtgtta acagagaaaa tgcaaaatgt     1200

ttcacaacca aagaggagct ggggaagaca gtgcctcagc tactgactcc tgggctgatg     1260

ggcgaatctt cagaatcctt tagtgcctca gaagatgaag gccacaggga ataccaagcc     1320

aatgactctg actcggacgg gcctatcttg tacaccgatg atgaggacga agacgaagat     1380

gaggatggca gtggagaaag tgctttggca agtaaaatac gccggaggga tactcttgct     1440

atcaaacttg gcaacagacc atctaagaaa gaactagagg acaaaaacat cttgcagcgt     1500

acatctgaag aagagaggca ggaaatccga caacaaattg gaaccaagtt agtcaggagg     1560

ctgagccaga ggcccacaac tgaagaatta gagcaaagaa acatcctaaa acaaaagaat     1620

gaagaagagg aacaagaagc aaaaatggaa cttaaacgca gactcagcag aaagctcagc     1680

ctgagaccca cagtggcaga gctacaagct cgaaggatcc tgcgatttaa cgagtatgta     1740

gaagtcacgg attctcctga ctatgaccgc cgagcagaca agccctgggc caggttaaca     1800

cctgcagaca aggcagcaat aaggaaagaa ctaaatgaat ttaaaagcac agaaatggaa     1860

gttcatgaag agagtcgaca gtttacaagg tttcatcgtc cataa                     1905


<210>  314
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Asp Asn Ala Val Asp Gly Leu Asp Lys Ala Ser Ile Ala Asn Ser 
1               5                   10                  15      


Asp Gly Pro Thr Ala Gly Ser Gln Thr Pro Pro Phe Lys Arg Lys Gly 
            20                  25                  30          


Lys Leu Ser Thr Ile Gly Lys Ile Phe Lys Pro Trp Lys Trp Arg Lys 
        35                  40                  45              


Lys Lys Thr Ser Asp Lys Phe Arg Glu Thr Ser Ala Val Leu Glu Arg 
    50                  55                  60                  


Lys Ile Ser Thr Arg Gln Ser Arg Glu Glu Leu Ile Arg Arg Gly Val 
65                  70                  75                  80  


Leu Lys Glu Leu Pro Asp Gln Asp Gly Asp Val Thr Val Asn Phe Glu 
                85                  90                  95      


Asn Ser Asn Gly His Met Ile Pro Ile Gly Glu Glu Ser Thr Arg Glu 
            100                 105                 110         


Glu Asn Val Val Lys Ser Glu Glu Gly Asn Gly Ser Val Ser Glu Lys 
        115                 120                 125             


Thr Pro Pro Leu Glu Glu Gln Ala Glu Asp Lys Lys Glu Asn Thr Glu 
    130                 135                 140                 


Asn His Ser Glu Thr Pro Ala Ala Pro Ala Leu Pro Pro Ser Ala Pro 
145                 150                 155                 160 


Pro Lys Pro Arg Pro Lys Pro Lys Pro Lys Lys Ser Pro Val Pro Pro 
                165                 170                 175     


Lys Gly Ala Thr Ala Gly Ala Ser His Lys Gly Asp Glu Val Pro Pro 
            180                 185                 190         


Ile Lys Lys Asn Thr Lys Ala Pro Gly Lys Gln Ala Pro Val Pro Pro 
        195                 200                 205             


Pro Lys Pro Ala Ser Arg Asn Thr Thr Arg Glu Ala Ala Gly Ser Ser 
    210                 215                 220                 


His Ser Lys Lys Thr Thr Gly Ser Lys Ala Ser Ala Ser Pro Ser Thr 
225                 230                 235                 240 


Ser Ser Thr Ser Ser Arg Pro Lys Ala Ser Lys Glu Thr Val Ser Ser 
                245                 250                 255     


Lys Ala Gly Thr Val Gly Thr Thr Lys Gly Lys Arg Lys Thr Asp Lys 
            260                 265                 270         


Gln Pro Ile Thr Ser His Leu Ser Ser Asp Thr Thr Thr Ser Gly Thr 
        275                 280                 285             


Ser Asp Leu Lys Gly Glu Pro Ala Glu Thr Arg Val Glu Ser Phe Lys 
    290                 295                 300                 


Leu Glu Gln Thr Val Pro Gly Ala Glu Glu Gln Asn Thr Gly Lys Phe 
305                 310                 315                 320 


Lys Ser Met Val Pro Pro Pro Pro Val Ala Pro Ala Pro Ser Pro Leu 
                325                 330                 335     


Ala Pro Pro Leu Pro Leu Glu Asp Gln Cys Ile Thr Ala Ser Asp Thr 
            340                 345                 350         


Pro Val Val Leu Val Ser Val Gly Ala Asp Leu Pro Val Ser Ala Leu 
        355                 360                 365             


Asp Pro Ser Gln Leu Leu Trp Ala Glu Glu Pro Thr Asn Arg Thr Thr 
    370                 375                 380                 


Leu Tyr Ser Gly Thr Gly Leu Ser Val Asn Arg Glu Asn Ala Lys Cys 
385                 390                 395                 400 


Phe Thr Thr Lys Glu Glu Leu Gly Lys Thr Val Pro Gln Leu Leu Thr 
                405                 410                 415     


Pro Gly Leu Met Gly Glu Ser Ser Glu Ser Phe Ser Ala Ser Glu Asp 
            420                 425                 430         


Glu Gly His Arg Glu Tyr Gln Ala Asn Asp Ser Asp Ser Asp Gly Pro 
        435                 440                 445             


Ile Leu Tyr Thr Asp Asp Glu Asp Glu Asp Glu Asp Glu Asp Gly Ser 
    450                 455                 460                 


Gly Glu Ser Ala Leu Ala Ser Lys Ile Arg Arg Arg Asp Thr Leu Ala 
465                 470                 475                 480 


Ile Lys Leu Gly Asn Arg Pro Ser Lys Lys Glu Leu Glu Asp Lys Asn 
                485                 490                 495     


Ile Leu Gln Arg Thr Ser Glu Glu Glu Arg Gln Glu Ile Arg Gln Gln 
            500                 505                 510         


Ile Gly Thr Lys Leu Val Arg Arg Leu Ser Gln Arg Pro Thr Thr Glu 
        515                 520                 525             


Glu Leu Glu Gln Arg Asn Ile Leu Lys Gln Lys Asn Glu Glu Glu Glu 
    530                 535                 540                 


Gln Glu Ala Lys Met Glu Leu Lys Arg Arg Leu Ser Arg Lys Leu Ser 
545                 550                 555                 560 


Leu Arg Pro Thr Val Ala Glu Leu Gln Ala Arg Arg Ile Leu Arg Phe 
                565                 570                 575     


Asn Glu Tyr Val Glu Val Thr Asp Ser Pro Asp Tyr Asp Arg Arg Ala 
            580                 585                 590         


Asp Lys Pro Trp Ala Arg Leu Thr Pro Ala Asp Lys Ala Ala Ile Arg 
        595                 600                 605             


Lys Glu Leu Asn Glu Phe Lys Ser Thr Glu Met Glu Val His Glu Glu 
    610                 615                 620                 


Ser Arg Gln Phe Thr Arg Phe His Arg Pro 
625                 630                 


<210>  315
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  315
atggagcgag ctgagagctc gagtacagaa cctgctaagg ccatcaaacc tattgatcgg       60

aagtcagtcc atcagatttg ctctgggcag gtggtactga gtctaagcac tgcggtaaag      120

gagttagtag aaaacagtct ggatgctggt gccactaata ttgatctaaa gcttaaggac      180

tatggagtgg atcttattga agtttcagac aatggatgtg gggtagaaga agaaaacttc      240

gaaggcttaa ctctgaaaca tcacacatct aagattcaag agtttgccga cctaactcag      300

gttgaaactt ttggctttcg gggggaagct ctgagctcac tttgtgcact gagcgatgtc      360

accatttcta cctgccacgc atcggcgaag gttggaactc gactgatgtt tgatcacaat      420

gggaaaatta tccagaaaac cccctacccc cgccccagag ggaccacagt cagcgtgcag      480

cagttatttt ccacactacc tgtgcgccat aaggaatttc aaaggaatat taagaaggag      540

tatgccaaaa tggtccaggt cttacatgca tactgtatca tttcagcagg catccgtgta      600

agttgcacca atcagcttgg acaaggaaaa cgacagcctg tggtatgcac aggtggaagc      660

cccagcataa aggaaaatat cggctctgtg tttgggcaga agcagttgca aagcctcatt      720

ccttttgttc agctgccccc tagtgactcc gtgtgtgaag agtacggttt gagctgttcc      780

gatgctctgc ataatctttt ttacatctca ggtttcattt cacaatgcac gcatggagtt      840

ggaaggagtt caacagacag acagtttttc tttatcaacc ggcggccttg tgacccagca      900

aaggtctgca gactcgtgaa tgaggtctac cacatgtata atcgacacca gtatccattt      960

gttgttctta acatttctgt tgattcagaa tgcgttgata tcaatgttac tccagataaa     1020

aggcaaattt tgctacaaga ggaaaagctt ttgttggcag ttttaaagac ctctttgata     1080

ggaatgtttg atagtgatgt caacaagcta aatgtcagtc agcagccact gctggatgtt     1140

gaaggtaact taataaaaat gcatgcagcg gatttggaaa agcccatggt agaaaagcag     1200

gatcaatccc cttcattaag gactggagaa gaaaaaaaag acgtgtccat ttccagactg     1260

cgagaggcct tttctcttcg tcacacaaca gagaacaagc ctcacagccc aaagactcca     1320

gaaccaagaa ggagccctct aggacagaaa aggggtatgc tgtcttctag cacttcaggt     1380

gccatctctg acaaaggcgt cctgagacct cagaaagagg cagtgagttc cagtcacgga     1440

cccagtgacc ctacggacag agcggaggtg gagaaggact cggggcacgg cagcacttcc     1500

gtggattctg aggggttcag catcccagac acgggcagtc actgcagcag cgagtatgcg     1560

gccagctccc caggggacag gggctcgcag gaacatgtgg actctcagga gaaagcgcct     1620

aaaactgacg actctttttc agatgtggac tgccattcaa accaggaaga taccggatgt     1680

aaatttcgag ttttgcctca gccaactaat ctcgcaaccc caaacacaaa gcgttttaaa     1740

aaagaagaaa ttctttccag ttctgacatt tgtcaaaagt tagtaaatac tcaggacatg     1800

tcagcctctc aggttgatgt agctgtgaaa attaataaga aagttgtgcc cctggacttt     1860

tctatgagtt ctttagctaa acgaataaag cagttacatc atgaagcaca gcaaagtgaa     1920

ggggaacaga attacaggaa gtttagggca aagatttgtc ctggagaaaa tcaagcagcc     1980

gaagatgaac taagaaaaga gataagtaaa acgatgtttg cagaaatgga aatcattggt     2040

cagtttaacc tgggatttat aataaccaaa ctgaatgagg atatcttcat agtggaccag     2100

catgccacgg acgagaagta taacttcgag atgctgcagc agcacaccgt gctccagggg     2160

cagaggctca tagcacctca gactctcaac ttaactgctg ttaatgaagc tgttctgata     2220

gaaaatctgg aaatatttag aaagaatggc tttgattttg ttatcgatga aaatgctcca     2280

gtcactgaaa gggctaaact gatttccttg ccaactagta aaaactggac cttcggaccc     2340

caggacgtcg atgaactgat cttcatgctg agcgacagcc ctggggtcat gtgccggcct     2400

tcccgagtca agcagatgtt tgcctccaga gcctgccgga agtcggtgat gattgggact     2460

gctcttaaca caagcgagat gaagaaactg atcacccaca tgggggagat ggaccacccc     2520

tggaactgtc cccatggaag gccaaccatg agacacatcg ccaacctggg tgtcatttct     2580

cagaactga                                                             2589


<210>  316
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys 
1               5                   10                  15      


Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val 
            20                  25                  30          


Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp 
    50                  55                  60                  


Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 
                85                  90                  95      


Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser 
            100                 105                 110         


Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His Ala Ser 
        115                 120                 125             


Ala Lys Val Gly Thr Arg Leu Met Phe Asp His Asn Gly Lys Ile Ile 
    130                 135                 140                 


Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly Thr Thr Val Ser Val Gln 
145                 150                 155                 160 


Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn 
                165                 170                 175     


Ile Lys Lys Glu Tyr Ala Lys Met Val Gln Val Leu His Ala Tyr Cys 
            180                 185                 190         


Ile Ile Ser Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu Gly Gln 
        195                 200                 205             


Gly Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser Pro Ser Ile Lys 
    210                 215                 220                 


Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu Gln Ser Leu Ile 
225                 230                 235                 240 


Pro Phe Val Gln Leu Pro Pro Ser Asp Ser Val Cys Glu Glu Tyr Gly 
                245                 250                 255     


Leu Ser Cys Ser Asp Ala Leu His Asn Leu Phe Tyr Ile Ser Gly Phe 
            260                 265                 270         


Ile Ser Gln Cys Thr His Gly Val Gly Arg Ser Ser Thr Asp Arg Gln 
        275                 280                 285             


Phe Phe Phe Ile Asn Arg Arg Pro Cys Asp Pro Ala Lys Val Cys Arg 
    290                 295                 300                 


Leu Val Asn Glu Val Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe 
305                 310                 315                 320 


Val Val Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp Ile Asn Val 
                325                 330                 335     


Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys Leu Leu Leu 
            340                 345                 350         


Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe Asp Ser Asp Val Asn 
        355                 360                 365             


Lys Leu Asn Val Ser Gln Gln Pro Leu Leu Asp Val Glu Gly Asn Leu 
    370                 375                 380                 


Ile Lys Met His Ala Ala Asp Leu Glu Lys Pro Met Val Glu Lys Gln 
385                 390                 395                 400 


Asp Gln Ser Pro Ser Leu Arg Thr Gly Glu Glu Lys Lys Asp Val Ser 
                405                 410                 415     


Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu Arg His Thr Thr Glu Asn 
            420                 425                 430         


Lys Pro His Ser Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu Gly 
        435                 440                 445             


Gln Lys Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala Ile Ser Asp 
    450                 455                 460                 


Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val Ser Ser Ser His Gly 
465                 470                 475                 480 


Pro Ser Asp Pro Thr Asp Arg Ala Glu Val Glu Lys Asp Ser Gly His 
                485                 490                 495     


Gly Ser Thr Ser Val Asp Ser Glu Gly Phe Ser Ile Pro Asp Thr Gly 
            500                 505                 510         


Ser His Cys Ser Ser Glu Tyr Ala Ala Ser Ser Pro Gly Asp Arg Gly 
        515                 520                 525             


Ser Gln Glu His Val Asp Ser Gln Glu Lys Ala Pro Lys Thr Asp Asp 
    530                 535                 540                 


Ser Phe Ser Asp Val Asp Cys His Ser Asn Gln Glu Asp Thr Gly Cys 
545                 550                 555                 560 


Lys Phe Arg Val Leu Pro Gln Pro Thr Asn Leu Ala Thr Pro Asn Thr 
                565                 570                 575     


Lys Arg Phe Lys Lys Glu Glu Ile Leu Ser Ser Ser Asp Ile Cys Gln 
            580                 585                 590         


Lys Leu Val Asn Thr Gln Asp Met Ser Ala Ser Gln Val Asp Val Ala 
        595                 600                 605             


Val Lys Ile Asn Lys Lys Val Val Pro Leu Asp Phe Ser Met Ser Ser 
    610                 615                 620                 


Leu Ala Lys Arg Ile Lys Gln Leu His His Glu Ala Gln Gln Ser Glu 
625                 630                 635                 640 


Gly Glu Gln Asn Tyr Arg Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu 
                645                 650                 655     


Asn Gln Ala Ala Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Thr Met 
            660                 665                 670         


Phe Ala Glu Met Glu Ile Ile Gly Gln Phe Asn Leu Gly Phe Ile Ile 
        675                 680                 685             


Thr Lys Leu Asn Glu Asp Ile Phe Ile Val Asp Gln His Ala Thr Asp 
    690                 695                 700                 


Glu Lys Tyr Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Gly 
705                 710                 715                 720 


Gln Arg Leu Ile Ala Pro Gln Thr Leu Asn Leu Thr Ala Val Asn Glu 
                725                 730                 735     


Ala Val Leu Ile Glu Asn Leu Glu Ile Phe Arg Lys Asn Gly Phe Asp 
            740                 745                 750         


Phe Val Ile Asp Glu Asn Ala Pro Val Thr Glu Arg Ala Lys Leu Ile 
        755                 760                 765             


Ser Leu Pro Thr Ser Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp 
    770                 775                 780                 


Glu Leu Ile Phe Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro 
785                 790                 795                 800 


Ser Arg Val Lys Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val 
                805                 810                 815     


Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys Lys Leu Ile Thr 
            820                 825                 830         


His Met Gly Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro 
        835                 840                 845             


Thr Met Arg His Ile Ala Asn Leu Gly Val Ile Ser Gln Asn 
    850                 855                 860         


<210>  317
<211>  6645
<212>  DNA
<213>  Homo sapiens

<400>  317
atgaaaagaa aagaaagaat tgccaggcgc ctggaaggga ttgaaaatga cactcagccc       60

atcctcttgc agagctgcac aggattggtg actcaccgcc tgctggagga agacacccct      120

cgatacatga gagccagcga ccctgccagc ccccacatcg gccgatcaaa tgaagaggag      180

gaaacttctg attcttctct agaaaagcaa actcgatcca aatactgcac agaaacctcc      240

ggtgtccacg gtgactcacc ctatggttcg ggtaccatgg acacccacag tctggagtcc      300

aaagccgaaa gaattgcaag gtacaaagca gaaagaaggc gacagctggc agagaagtat      360

gggctgactc tggatcccga ggccgactcc gagtatttat cccgctatac caagtccagg      420

aaggagcctg atgctgtcga gaagcgggga ggaaaaagtg acaaacagga agagtcaagc      480

agagatgcta gttctctgta ccccgggacc gagacgatgg ggctcaggac ctgtgccggt      540

gaatccaagg actatgccct ccatgtgggt gacggctctt ccgacccgga ggtgctgctg      600

aacatagaaa accaaagacg aggtcaagag ctgagtgcca cccggcaggc ccatgacctg      660

tccccagcag ccgagagttc ctcgaccttc tctttctctg ggcgagactc ctccttcact      720

gaagtgccac ggtcccccaa gcacgcccac agctcctccc tgcagcaggc agcctcccgg      780

agcccctcct ttggtgaccc acagctatcc cctgaggccc gacccagtac agggaaaccc      840

aaacatgagt ggtttctcca gaaagattcc gaaggggaca caccttcact tatcaactgg      900

ccttccagag ttaaagttag agaaaaattg gtgaaagagg aaagtgctcg aaacagccct      960

gaactcgcct cagagtccgt aactcagagg agacaccagc cagcgccagt ccattacgtg     1020

tcatttcagt ctgagcactc agcctttgat agggtcccca gcaaggcagc aggctctaca     1080

cgacagccaa tccgtggcta tgtccaaccc gcagataccg gtcacaccgc caagctagtg     1140

acgccagaaa ccccagaaaa tgcatctgag tgtagctggg tagcatcagc cacccagaat     1200

gtccccaaac ctcccagctt gacggttcta gaaggtgacg gaagggatag cccagttctc     1260

catgtctgcg agtcaaaagc agaagaagaa gaaggggaag gagaaggaga agaaaaagaa     1320

gaagatgtgt gcttcactga agctctcgag caaagcaaga aaaccctact ggctttggag     1380

ggtgatgggc tagtgagaag cccagaagat ccctctagaa atgaggactt tggtaagcct     1440

gctgtgagca cagtcacctt agagcatcag aaggaactgg aaaacgtggc acaaccccct     1500

caagctccgc accagcccac tgagaggaca ggcaggagcg agatggttct ctacattcaa     1560

agtgagcctg tgtcccaaga cgccaaacca actggtcaca acagggaagc ctcgaaaaag     1620

cgcaaggtcc gtacccgctc tctgtcagat ttcacaggcc cccctcagct ccaggccttg     1680

aagtataagg acccagcttc caggagagag ctggagctgc ccagctccaa gaccgaaggg     1740

ccttatgggg agatcagcat gctggacaca aaagtctctg tcgcccagct ccgaagtgcg     1800

ttcctggcat ctgccaacgc ctgcaggaga cctgaactca aatcacgggt ggagaggtcg     1860

gctgaaggac ctggcttgcc caccggtgtg gaacgggaga gagggtcccg gaaaccaaga     1920

cgctattttt ctcctggtga aagtagaaaa acttccgaga gatttagaac ccaacctata     1980

acttcagcag aacgaaagga atcggatagg tgcacttcac attcagaaac gccaactgtc     2040

gatgatgaag aaaaggtgga tgaacgagcc aagctgagcg tcgccgccaa gaggttgctt     2100

ttcagggaga tggaaaaatc ttttgatgaa caaaatgttc caaagcgacg ctcaagaaac     2160

acagctgtgg agcagaggct acgccgtctg caggacaggt ccctcaccca gcccatcacc     2220

actgaagagg tggtcatcgc agccactgaa cctatccccg cttcgtgttc tgggggcacc     2280

caccctgtaa tggcgagact tcctagcccc actgtagcta ggagcgctgt gcagcctgcc     2340

agattgcagg cctctgctca ccaaaaggcc ttagccaagg accagacaaa tgagggcaaa     2400

gagcttgctg agcaaggaga acctgattcc tccactctaa gcttggccga aaagttggcc     2460

ttgtttaaca aattgtccca gccagtctca aaagcgattt ctacccggaa cagaatagac     2520

acgagacaga ggagaatgaa cgctcgctat caaactcagc cagtcacact gggagaggtg     2580

gagcaggtgc agagtggaaa gctcattcct ttctcacctg ccgtgaacac atcagtgtct     2640

accgtagcat ccacggttgc tccaatgtat gccggagatc ttcgcacaaa gccacctctt     2700

gaccacaatg caagtgccac tgactataag ttttcttctt caatagaaaa ttcggactct     2760

ccagttagaa gcattctgaa atcgcaagct tggcagcctt tggtagaggg tagcgagaac     2820

aagggaatgt tgagagaata tggagagaca gaaagcaaga gagctttgac aggtcgagac     2880

agtgggatgg agaagtatgg gtcctttgag gaagcagaag catcctaccc catcctgaac     2940

cgagccaggg aaggagacag ccataaggaa tctaaatatg ctgttcccag aagaggaagc     3000

ctggaacggg cgaaccctcc catcacccac ctcggggatg aaccgaagga attttccatg     3060

gctaaaatga atgcacaagg aaacttggac ttgagggaca ggctgccctt tgaagagaag     3120

gtggaggtgg agaatgttat gaaaaggaag ttttcactaa gagcggcaga gttcggggag     3180

cccacttccg agcagacggg gacagctgct gggaaaacta ttgctcaaac cacagccccc     3240

gtgtcctgga agccccagga ttcttcggaa cagccacagg agaagctctg caagaatcca     3300

tgtgcgatgt ttgctgctgg agagatcaaa acgccgacag gggagggcct tcttgactca     3360

cccagcaaaa ccatgtctat taaagaaaga ttggcactgt tgaagaaaag cggggaggaa     3420

gattggagaa acagactcag caggaggcag gagggcggca aggcgccggc cagcagcctg     3480

cacacccagg aagcagggcg gtccctcatc aagaagcggg tcacagaaag tcgagagagc     3540

caaatgacga ttgaggagag gaagcagctc atcactgtga gagaggaggc ctggaagacg     3600

agaggcagag gagcggccaa cgactcgacc cagttcactg tggctggcag gatggtgaag     3660

aaaggtttgg cgtcacctac tgccataacc ccagtagcct cacccatttg cggtaaaaca     3720

agaggcacca cacccgtttc caaacccctg gaagatatcg aagccagacc agatatgcag     3780

ttagaatcgg acctgaagtt ggacaggctg gaaacctttc taagaaggct gaataacaaa     3840

gttggcggga tgcacgaaac ggtgctcact gtcaccggca aatctgtgaa ggaggtgatg     3900

aagccagatg atgatgaaac ctttgccaaa ttttaccgca gcgtggatta taatatgcca     3960

agaagtcctg tggagatgga tgaggacttc gatgtcattt tcgatcctta tgcacccaaa     4020

ttgacgtctt ccgtggccga gcacaagcgg gcagttaggc ccaagcgccg ggttcaggcc     4080

tccaaaaacc ccctgaaaat gctggcggca agagaagatc tccttcagga atacactgag     4140

cagagattaa acgttgcctt catggagtca aagcggatga aagtagaaaa gatgtcttcc     4200

aactccaact tctcagaagt caccctggcg ggtttagcca gtaaagaaaa cttcagcaac     4260

gtcagcctgc ggagcgtcaa cctgacggaa cagaactcta acaacagcgc cgtgccctac     4320

aagaggctga tgctgttgca gattaaagga agaagacatg tgcagaccag gctggtggaa     4380

cctcgagctt cggcgctcaa cagtggggac tgcttcctcc tgctctctcc ccactgctgc     4440

ttcctgtggg taggagagtt tgcaaacgtc atagaaaagg cgaaggcctc agaacttgca     4500

actttaattc agacaaagag ggaacttggt tgtagagcta cttatatcca aaccattgaa     4560

gaaggaatta atacacacac tcatgcagcc aaagacttct ggaagcttct gggtggccaa     4620

accagttacc aatctgctgg agacccaaaa gaagatgaac tctatgaagc agccataata     4680

gaaactaact gcatttaccg tctcatggat gacaaacttg ttcctgatga cgactactgg     4740

gggaaaattc cgaagtgctc ccttctgcaa cccaaagagg tactggtgtt tgattttggt     4800

agtgaagttt acgtatggca tgggaaagaa gtcacattag cacaacgaaa aatagcattt     4860

cagctggcaa agcacttatg gaatggaacc tttgactatg agaactgtga catcaatccc     4920

ctggatcctg gagaatgcaa tccgcttatc cccagaaaag gacaggggcg gcccgactgg     4980

gcgatatttg ggagacttac tgaacacaat gagacgattt tgttcaaaga gaagtttctg     5040

gattggacgg aactgaagag atcgaatgag aagaaccccg gggaacttgc ccagcacaag     5100

gaagacccca ggactgatgt caaggcatac gatgtgacac ggatggtgtc catgccccag     5160

acgacagcag gcaccatcct ggacggagtg aacgtcggcc gtggctatgg cctggtggaa     5220

ggacacgaca ggaggcagtt tgagatcacc agcgtttccg tggatgtctg gcacatcctg     5280

gaattcgact atagcaggct ccccaaacaa agcatcgggc agttccatga gggggatgcc     5340

tatgtggtca agtggaagtt catggtgagc acggcagtgg gaagtcgcca gaagggagag     5400

cactcggtga gggcagccgg caaagagaag tgcgtctact tcttctggca aggccggcac     5460

tccaccgtga gtgagaaggg cacgtcggcg ctgatgacgg tggagctgga cgaggaaagg     5520

ggggcccagg tccaggttct ccagggaaag gagcccccct gtttcctgca gtgtttccag     5580

ggggggatgg tggtgcactc ggggaggcgg gaagaggaag aagaaaatgt gcaaagtgag     5640

tggcggctgt actgcgtgcg tggagaggtg cccgtggaag ggaatttgct ggaagtggcc     5700

tgtcactgta gcagcctgag gtccagaact tccatggtgg tgcttaacgt caacaaggcc     5760

ctcatctacc tgtggcacgg atgcaaagcc caggcccaca cgaaggaggt cggaaggacc     5820

gctgcgaaca agatcaagga acaatgtccc ctggaagcag gactgcatag tagcagcaaa     5880

gtcacaatac acgagtgtga tgaaggctcc gagccactcg gattctggga tgccttagga     5940

aggagagaca ggaaagccta cgattgcatg cttcaagatc ctggaagttt taacttcgcg     6000

ccccgcctgt tcatcctcag cagctcctct ggggattttg cagccacaga gtttgtgtac     6060

cctgcccgag ccccctctgt ggtcagttcc atgcccttcc tgcaggaaga tctgtacagc     6120

gcgccccagc cagcactttt ccttgttgac aatcaccacg aggtgtacct ctggcaaggc     6180

tggtggccca tcgagaacaa gatcactggt tccgcccgca tccgctgggc ctccgaccgg     6240

aagagtgcga tggagactgt gctccagtac tgcaaaggaa aaaatctcaa gaaaccagcc     6300

cccaagtctt accttatcca cgctggtctg gagcccctga cattcaccaa tatgtttccc     6360

agctgggagc acagagagga catcgctgag atcacagaga tggacacgga agtttccaat     6420

cagatcaccc tcgtggaaga cgtcttagcc aagctctgta aaaccattta cccgctggcc     6480

gacctcctgg ccaggccact cccggagggg gtcgatcctc tgaagcttga gatctatctc     6540

accgacgaag acttcgagtt tgcactagac atgacgaggg atgaatacaa cgccctgccc     6600

gcctggaagc aggtgaacct gaagaaagca aaaggcctgt tctga                     6645


<210>  318
<211>  2214
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn 
1               5                   10                  15      


Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His 
            20                  25                  30          


Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro 
        35                  40                  45              


Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp 
    50                  55                  60                  


Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser 
65                  70                  75                  80  


Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His 
                85                  90                  95      


Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg 
            100                 105                 110         


Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala 
        115                 120                 125             


Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp 
    130                 135                 140                 


Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser 
145                 150                 155                 160 


Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg 
                165                 170                 175     


Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Val Gly Asp Gly 
            180                 185                 190         


Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly 
        195                 200                 205             


Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala 
    210                 215                 220                 


Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr 
225                 230                 235                 240 


Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln 
                245                 250                 255     


Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu 
            260                 265                 270         


Ala Arg Pro Ser Thr Gly Lys Pro Lys His Glu Trp Phe Leu Gln Lys 
        275                 280                 285             


Asp Ser Glu Gly Asp Thr Pro Ser Leu Ile Asn Trp Pro Ser Arg Val 
    290                 295                 300                 


Lys Val Arg Glu Lys Leu Val Lys Glu Glu Ser Ala Arg Asn Ser Pro 
305                 310                 315                 320 


Glu Leu Ala Ser Glu Ser Val Thr Gln Arg Arg His Gln Pro Ala Pro 
                325                 330                 335     


Val His Tyr Val Ser Phe Gln Ser Glu His Ser Ala Phe Asp Arg Val 
            340                 345                 350         


Pro Ser Lys Ala Ala Gly Ser Thr Arg Gln Pro Ile Arg Gly Tyr Val 
        355                 360                 365             


Gln Pro Ala Asp Thr Gly His Thr Ala Lys Leu Val Thr Pro Glu Thr 
    370                 375                 380                 


Pro Glu Asn Ala Ser Glu Cys Ser Trp Val Ala Ser Ala Thr Gln Asn 
385                 390                 395                 400 


Val Pro Lys Pro Pro Ser Leu Thr Val Leu Glu Gly Asp Gly Arg Asp 
                405                 410                 415     


Ser Pro Val Leu His Val Cys Glu Ser Lys Ala Glu Glu Glu Glu Gly 
            420                 425                 430         


Glu Gly Glu Gly Glu Glu Lys Glu Glu Asp Val Cys Phe Thr Glu Ala 
        435                 440                 445             


Leu Glu Gln Ser Lys Lys Thr Leu Leu Ala Leu Glu Gly Asp Gly Leu 
    450                 455                 460                 


Val Arg Ser Pro Glu Asp Pro Ser Arg Asn Glu Asp Phe Gly Lys Pro 
465                 470                 475                 480 


Ala Val Ser Thr Val Thr Leu Glu His Gln Lys Glu Leu Glu Asn Val 
                485                 490                 495     


Ala Gln Pro Pro Gln Ala Pro His Gln Pro Thr Glu Arg Thr Gly Arg 
            500                 505                 510         


Ser Glu Met Val Leu Tyr Ile Gln Ser Glu Pro Val Ser Gln Asp Ala 
        515                 520                 525             


Lys Pro Thr Gly His Asn Arg Glu Ala Ser Lys Lys Arg Lys Val Arg 
    530                 535                 540                 


Thr Arg Ser Leu Ser Asp Phe Thr Gly Pro Pro Gln Leu Gln Ala Leu 
545                 550                 555                 560 


Lys Tyr Lys Asp Pro Ala Ser Arg Arg Glu Leu Glu Leu Pro Ser Ser 
                565                 570                 575     


Lys Thr Glu Gly Pro Tyr Gly Glu Ile Ser Met Leu Asp Thr Lys Val 
            580                 585                 590         


Ser Val Ala Gln Leu Arg Ser Ala Phe Leu Ala Ser Ala Asn Ala Cys 
        595                 600                 605             


Arg Arg Pro Glu Leu Lys Ser Arg Val Glu Arg Ser Ala Glu Gly Pro 
    610                 615                 620                 


Gly Leu Pro Thr Gly Val Glu Arg Glu Arg Gly Ser Arg Lys Pro Arg 
625                 630                 635                 640 


Arg Tyr Phe Ser Pro Gly Glu Ser Arg Lys Thr Ser Glu Arg Phe Arg 
                645                 650                 655     


Thr Gln Pro Ile Thr Ser Ala Glu Arg Lys Glu Ser Asp Arg Cys Thr 
            660                 665                 670         


Ser His Ser Glu Thr Pro Thr Val Asp Asp Glu Glu Lys Val Asp Glu 
        675                 680                 685             


Arg Ala Lys Leu Ser Val Ala Ala Lys Arg Leu Leu Phe Arg Glu Met 
    690                 695                 700                 


Glu Lys Ser Phe Asp Glu Gln Asn Val Pro Lys Arg Arg Ser Arg Asn 
705                 710                 715                 720 


Thr Ala Val Glu Gln Arg Leu Arg Arg Leu Gln Asp Arg Ser Leu Thr 
                725                 730                 735     


Gln Pro Ile Thr Thr Glu Glu Val Val Ile Ala Ala Thr Glu Pro Ile 
            740                 745                 750         


Pro Ala Ser Cys Ser Gly Gly Thr His Pro Val Met Ala Arg Leu Pro 
        755                 760                 765             


Ser Pro Thr Val Ala Arg Ser Ala Val Gln Pro Ala Arg Leu Gln Ala 
    770                 775                 780                 


Ser Ala His Gln Lys Ala Leu Ala Lys Asp Gln Thr Asn Glu Gly Lys 
785                 790                 795                 800 


Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser Ser Thr Leu Ser Leu Ala 
                805                 810                 815     


Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser Gln Pro Val Ser Lys Ala 
            820                 825                 830         


Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg Gln Arg Arg Met Asn Ala 
        835                 840                 845             


Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly Glu Val Glu Gln Val Gln 
    850                 855                 860                 


Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala Val Asn Thr Ser Val Ser 
865                 870                 875                 880 


Thr Val Ala Ser Thr Val Ala Pro Met Tyr Ala Gly Asp Leu Arg Thr 
                885                 890                 895     


Lys Pro Pro Leu Asp His Asn Ala Ser Ala Thr Asp Tyr Lys Phe Ser 
            900                 905                 910         


Ser Ser Ile Glu Asn Ser Asp Ser Pro Val Arg Ser Ile Leu Lys Ser 
        915                 920                 925             


Gln Ala Trp Gln Pro Leu Val Glu Gly Ser Glu Asn Lys Gly Met Leu 
    930                 935                 940                 


Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg Ala Leu Thr Gly Arg Asp 
945                 950                 955                 960 


Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu Glu Ala Glu Ala Ser Tyr 
                965                 970                 975     


Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp Ser His Lys Glu Ser Lys 
            980                 985                 990         


Tyr Ala Val Pro Arg Arg Gly Ser  Leu Glu Arg Ala Asn  Pro Pro Ile 
        995                 1000                 1005             


Thr His  Leu Gly Asp Glu Pro  Lys Glu Phe Ser Met  Ala Lys Met 
    1010                 1015                 1020             


Asn Ala  Gln Gly Asn Leu Asp  Leu Arg Asp Arg Leu  Pro Phe Glu 
    1025                 1030                 1035             


Glu Lys  Val Glu Val Glu Asn  Val Met Lys Arg Lys  Phe Ser Leu 
    1040                 1045                 1050             


Arg Ala  Ala Glu Phe Gly Glu  Pro Thr Ser Glu Gln  Thr Gly Thr 
    1055                 1060                 1065             


Ala Ala  Gly Lys Thr Ile Ala  Gln Thr Thr Ala Pro  Val Ser Trp 
    1070                 1075                 1080             


Lys Pro  Gln Asp Ser Ser Glu  Gln Pro Gln Glu Lys  Leu Cys Lys 
    1085                 1090                 1095             


Asn Pro  Cys Ala Met Phe Ala  Ala Gly Glu Ile Lys  Thr Pro Thr 
    1100                 1105                 1110             


Gly Glu  Gly Leu Leu Asp Ser  Pro Ser Lys Thr Met  Ser Ile Lys 
    1115                 1120                 1125             


Glu Arg  Leu Ala Leu Leu Lys  Lys Ser Gly Glu Glu  Asp Trp Arg 
    1130                 1135                 1140             


Asn Arg  Leu Ser Arg Arg Gln  Glu Gly Gly Lys Ala  Pro Ala Ser 
    1145                 1150                 1155             


Ser Leu  His Thr Gln Glu Ala  Gly Arg Ser Leu Ile  Lys Lys Arg 
    1160                 1165                 1170             


Val Thr  Glu Ser Arg Glu Ser  Gln Met Thr Ile Glu  Glu Arg Lys 
    1175                 1180                 1185             


Gln Leu  Ile Thr Val Arg Glu  Glu Ala Trp Lys Thr  Arg Gly Arg 
    1190                 1195                 1200             


Gly Ala  Ala Asn Asp Ser Thr  Gln Phe Thr Val Ala  Gly Arg Met 
    1205                 1210                 1215             


Val Lys  Lys Gly Leu Ala Ser  Pro Thr Ala Ile Thr  Pro Val Ala 
    1220                 1225                 1230             


Ser Pro  Ile Cys Gly Lys Thr  Arg Gly Thr Thr Pro  Val Ser Lys 
    1235                 1240                 1245             


Pro Leu  Glu Asp Ile Glu Ala  Arg Pro Asp Met Gln  Leu Glu Ser 
    1250                 1255                 1260             


Asp Leu  Lys Leu Asp Arg Leu  Glu Thr Phe Leu Arg  Arg Leu Asn 
    1265                 1270                 1275             


Asn Lys  Val Gly Gly Met His  Glu Thr Val Leu Thr  Val Thr Gly 
    1280                 1285                 1290             


Lys Ser  Val Lys Glu Val Met  Lys Pro Asp Asp Asp  Glu Thr Phe 
    1295                 1300                 1305             


Ala Lys  Phe Tyr Arg Ser Val  Asp Tyr Asn Met Pro  Arg Ser Pro 
    1310                 1315                 1320             


Val Glu  Met Asp Glu Asp Phe  Asp Val Ile Phe Asp  Pro Tyr Ala 
    1325                 1330                 1335             


Pro Lys  Leu Thr Ser Ser Val  Ala Glu His Lys Arg  Ala Val Arg 
    1340                 1345                 1350             


Pro Lys  Arg Arg Val Gln Ala  Ser Lys Asn Pro Leu  Lys Met Leu 
    1355                 1360                 1365             


Ala Ala  Arg Glu Asp Leu Leu  Gln Glu Tyr Thr Glu  Gln Arg Leu 
    1370                 1375                 1380             


Asn Val  Ala Phe Met Glu Ser  Lys Arg Met Lys Val  Glu Lys Met 
    1385                 1390                 1395             


Ser Ser  Asn Ser Asn Phe Ser  Glu Val Thr Leu Ala  Gly Leu Ala 
    1400                 1405                 1410             


Ser Lys  Glu Asn Phe Ser Asn  Val Ser Leu Arg Ser  Val Asn Leu 
    1415                 1420                 1425             


Thr Glu  Gln Asn Ser Asn Asn  Ser Ala Val Pro Tyr  Lys Arg Leu 
    1430                 1435                 1440             


Met Leu  Leu Gln Ile Lys Gly  Arg Arg His Val Gln  Thr Arg Leu 
    1445                 1450                 1455             


Val Glu  Pro Arg Ala Ser Ala  Leu Asn Ser Gly Asp  Cys Phe Leu 
    1460                 1465                 1470             


Leu Leu  Ser Pro His Cys Cys  Phe Leu Trp Val Gly  Glu Phe Ala 
    1475                 1480                 1485             


Asn Val  Ile Glu Lys Ala Lys  Ala Ser Glu Leu Ala  Thr Leu Ile 
    1490                 1495                 1500             


Gln Thr  Lys Arg Glu Leu Gly  Cys Arg Ala Thr Tyr  Ile Gln Thr 
    1505                 1510                 1515             


Ile Glu  Glu Gly Ile Asn Thr  His Thr His Ala Ala  Lys Asp Phe 
    1520                 1525                 1530             


Trp Lys  Leu Leu Gly Gly Gln  Thr Ser Tyr Gln Ser  Ala Gly Asp 
    1535                 1540                 1545             


Pro Lys  Glu Asp Glu Leu Tyr  Glu Ala Ala Ile Ile  Glu Thr Asn 
    1550                 1555                 1560             


Cys Ile  Tyr Arg Leu Met Asp  Asp Lys Leu Val Pro  Asp Asp Asp 
    1565                 1570                 1575             


Tyr Trp  Gly Lys Ile Pro Lys  Cys Ser Leu Leu Gln  Pro Lys Glu 
    1580                 1585                 1590             


Val Leu  Val Phe Asp Phe Gly  Ser Glu Val Tyr Val  Trp His Gly 
    1595                 1600                 1605             


Lys Glu  Val Thr Leu Ala Gln  Arg Lys Ile Ala Phe  Gln Leu Ala 
    1610                 1615                 1620             


Lys His  Leu Trp Asn Gly Thr  Phe Asp Tyr Glu Asn  Cys Asp Ile 
    1625                 1630                 1635             


Asn Pro  Leu Asp Pro Gly Glu  Cys Asn Pro Leu Ile  Pro Arg Lys 
    1640                 1645                 1650             


Gly Gln  Gly Arg Pro Asp Trp  Ala Ile Phe Gly Arg  Leu Thr Glu 
    1655                 1660                 1665             


His Asn  Glu Thr Ile Leu Phe  Lys Glu Lys Phe Leu  Asp Trp Thr 
    1670                 1675                 1680             


Glu Leu  Lys Arg Ser Asn Glu  Lys Asn Pro Gly Glu  Leu Ala Gln 
    1685                 1690                 1695             


His Lys  Glu Asp Pro Arg Thr  Asp Val Lys Ala Tyr  Asp Val Thr 
    1700                 1705                 1710             


Arg Met  Val Ser Met Pro Gln  Thr Thr Ala Gly Thr  Ile Leu Asp 
    1715                 1720                 1725             


Gly Val  Asn Val Gly Arg Gly  Tyr Gly Leu Val Glu  Gly His Asp 
    1730                 1735                 1740             


Arg Arg  Gln Phe Glu Ile Thr  Ser Val Ser Val Asp  Val Trp His 
    1745                 1750                 1755             


Ile Leu  Glu Phe Asp Tyr Ser  Arg Leu Pro Lys Gln  Ser Ile Gly 
    1760                 1765                 1770             


Gln Phe  His Glu Gly Asp Ala  Tyr Val Val Lys Trp  Lys Phe Met 
    1775                 1780                 1785             


Val Ser  Thr Ala Val Gly Ser  Arg Gln Lys Gly Glu  His Ser Val 
    1790                 1795                 1800             


Arg Ala  Ala Gly Lys Glu Lys  Cys Val Tyr Phe Phe  Trp Gln Gly 
    1805                 1810                 1815             


Arg His  Ser Thr Val Ser Glu  Lys Gly Thr Ser Ala  Leu Met Thr 
    1820                 1825                 1830             


Val Glu  Leu Asp Glu Glu Arg  Gly Ala Gln Val Gln  Val Leu Gln 
    1835                 1840                 1845             


Gly Lys  Glu Pro Pro Cys Phe  Leu Gln Cys Phe Gln  Gly Gly Met 
    1850                 1855                 1860             


Val Val  His Ser Gly Arg Arg  Glu Glu Glu Glu Glu  Asn Val Gln 
    1865                 1870                 1875             


Ser Glu  Trp Arg Leu Tyr Cys  Val Arg Gly Glu Val  Pro Val Glu 
    1880                 1885                 1890             


Gly Asn  Leu Leu Glu Val Ala  Cys His Cys Ser Ser  Leu Arg Ser 
    1895                 1900                 1905             


Arg Thr  Ser Met Val Val Leu  Asn Val Asn Lys Ala  Leu Ile Tyr 
    1910                 1915                 1920             


Leu Trp  His Gly Cys Lys Ala  Gln Ala His Thr Lys  Glu Val Gly 
    1925                 1930                 1935             


Arg Thr  Ala Ala Asn Lys Ile  Lys Glu Gln Cys Pro  Leu Glu Ala 
    1940                 1945                 1950             


Gly Leu  His Ser Ser Ser Lys  Val Thr Ile His Glu  Cys Asp Glu 
    1955                 1960                 1965             


Gly Ser  Glu Pro Leu Gly Phe  Trp Asp Ala Leu Gly  Arg Arg Asp 
    1970                 1975                 1980             


Arg Lys  Ala Tyr Asp Cys Met  Leu Gln Asp Pro Gly  Ser Phe Asn 
    1985                 1990                 1995             


Phe Ala  Pro Arg Leu Phe Ile  Leu Ser Ser Ser Ser  Gly Asp Phe 
    2000                 2005                 2010             


Ala Ala  Thr Glu Phe Val Tyr  Pro Ala Arg Ala Pro  Ser Val Val 
    2015                 2020                 2025             


Ser Ser  Met Pro Phe Leu Gln  Glu Asp Leu Tyr Ser  Ala Pro Gln 
    2030                 2035                 2040             


Pro Ala  Leu Phe Leu Val Asp  Asn His His Glu Val  Tyr Leu Trp 
    2045                 2050                 2055             


Gln Gly  Trp Trp Pro Ile Glu  Asn Lys Ile Thr Gly  Ser Ala Arg 
    2060                 2065                 2070             


Ile Arg  Trp Ala Ser Asp Arg  Lys Ser Ala Met Glu  Thr Val Leu 
    2075                 2080                 2085             


Gln Tyr  Cys Lys Gly Lys Asn  Leu Lys Lys Pro Ala  Pro Lys Ser 
    2090                 2095                 2100             


Tyr Leu  Ile His Ala Gly Leu  Glu Pro Leu Thr Phe  Thr Asn Met 
    2105                 2110                 2115             


Phe Pro  Ser Trp Glu His Arg  Glu Asp Ile Ala Glu  Ile Thr Glu 
    2120                 2125                 2130             


Met Asp  Thr Glu Val Ser Asn  Gln Ile Thr Leu Val  Glu Asp Val 
    2135                 2140                 2145             


Leu Ala  Lys Leu Cys Lys Thr  Ile Tyr Pro Leu Ala  Asp Leu Leu 
    2150                 2155                 2160             


Ala Arg  Pro Leu Pro Glu Gly  Val Asp Pro Leu Lys  Leu Glu Ile 
    2165                 2170                 2175             


Tyr Leu  Thr Asp Glu Asp Phe  Glu Phe Ala Leu Asp  Met Thr Arg 
    2180                 2185                 2190             


Asp Glu  Tyr Asn Ala Leu Pro  Ala Trp Lys Gln Val  Asn Leu Lys 
    2195                 2200                 2205             


Lys Ala  Lys Gly Leu Phe 
    2210                 


<210>  319
<211>  2517
<212>  DNA
<213>  Homo sapiens

<400>  319
atgtacgcct tttactcgtt gctcatctac atcttctaca gcctcttccg cagggatggt       60

ggcgccgcgg cggccgcgga gcccggggac cccgcccaga gagcccgcaa gccccggggt      120

cgccggcgcc cagacctgcc cgcgccagag ctgtggaccg agctgaccgg cctggccgcc      180

agctccgagc ctgaggatgg gtcggaaggc gcagccgagg gccgcgcggc cgcggtgtcc      240

ctggaagagg ccctactgcg cctcgccgag ttcctctccg tccagctggg ggcggaagag      300

agctgcgggg gcccggcgga cctgggccag tctggcgagg tcccctcact gttgacagtg      360

accagtcagc tcttggccct tctggcatgg cttcgaagcc ccagggggag gcaggccctg      420

ctccagggga ctcagccagc ccctcgggtc cggcccccct ctccagatgg atccacatcc      480

caagaagaaa gcccttccca cttcaccgca gtcccaggcg agccactggg ggatgagacc      540

cagggacagc agcccctcca gttggaggag gatcagaggg cgtggcagcg gctggagcag      600

ctcatcctgg gacagctgga ggagctgaag cagcagctgg aacagcagga ggaggagttg      660

ggtcgactgc gcctgggcgt gggggcgacg gactcagaga aaagggttca gcatctgact      720

ctggagaacg aggccctgaa gcagagcctg agtctcatgc gggacctcct gctgcactgg      780

ggccccgggc cccccatcag ggctccgcag gaggaggcag aggcattgct agagctccag      840

ggccggcttc aggaggccca agacaccaca gaagccctcc gagcccagct gggggtgcag      900

gaggtgcagc tgcagggcct tcaaggggcc ctccagcagc tccagcagga gacggagcag      960

aactgcaggc gtgagctaca gcagatgcat gggcagctgg caggacttcg ggcacggatg     1020

gccagcctgc gtcagggctg cggggacctc cgaggtttgg tcagcacctt tacccagagc     1080

tgtcagggtt cgctgagtga ggcccggggc caggtgtcct gggccttggg ggcactgtca     1140

tctggagggc ctggcactca gctccctgag gggcagcaag ggcccccagc cggatgccca     1200

gggcggctgc cagaactcaa gggaaatatc cgtgtgctgt gtcggctgag gccagggaca     1260

tcttctagcc ttgtgagtgt ggagcctggc ccagggggca ccgtcaccac ctgctaccgg     1320

gggcgccatc gtcgattccg cctagactgg gtcttccctc cagacgccag ccaggaggag     1380

gtcttcagag agctggaacc tgcggtgctg tcctgcctcc gaggctacag cgtctgcatc     1440

ttcacctatg gccagacagg caccgggaag acctacagca tggagggccc tcctgaggac     1500

cccggcatag ttcctagggc gctgcagtcg ctgttccggg agatgggggc cggccggcag     1560

caccgggtga cactcagcat ggtggagatc tacaatgagg ctgtcaggga cctccttgct     1620

ccagggcctc ccgagcgcct ggccgtgagg cagggcccag aaggccaggg cgggatccag     1680

gtggctggcc tcacccactg ggacgtgccc aacctggaga cattgcacca gatgctgaaa     1740

ctggggagga gcaaccgggc caccgccgcc accgccatga accagcgcag ctcccgctcg     1800

catgccctgg tcacgctgac gctgcgcgcg gcgtctccac cgcgcgctcc aggcaccgca     1860

ggcacgctgc acctggtgga cctggcggga tccgaacgcg cacggaaggc aggggcggcc     1920

ggcccgccgc ggggagaccc agacggcgcc cggcgcctgc gggaggccca gaccataaac     1980

cgctcgctgc tggcgctagg aggcgtgatg gccgcactgc gggcccaccg gccgcacgtg     2040

cccttccgcg actcgcagct cacgcgactg ctgcagccgg cgctgggccc aggcaccacc     2100

gcggtgctgc tgctgcaggt gggcgccggg gcggggcagg tgtgtgcgtg ccggtcgccg     2160

cccacccggg cccgcccacc cgcgcctctt gcccgcagat ctccacgcgg ccggaggatc     2220

tcggggagac agtctgctcc ctcaagttcg ccgaccgagt gggtcaagtg gagctggggc     2280

cagcccggcg ccgcagggtc ccgcgctcct ccgggacgcc ttcttccctc agcaccgaca     2340

ctccgctcac cgggaccccc tgcaccccta cgccgtcccc tggcagtcct ccatgcccca     2400

gtcccgacaa cggctcgggc tcggctctcg cgcccgcaga gggcctgccc ctctagtcct     2460

gggtcgcggc cctgcccatg gggtctcagg ccaggtctct gctggcagag gcggtag        2517


<210>  320
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Tyr Ala Phe Tyr Ser Leu Leu Ile Tyr Ile Phe Tyr Ser Leu Phe 
1               5                   10                  15      


Arg Arg Asp Gly Gly Ala Ala Ala Ala Ala Glu Pro Gly Asp Pro Ala 
            20                  25                  30          


Gln Arg Ala Arg Lys Pro Arg Gly Arg Arg Arg Pro Asp Leu Pro Ala 
        35                  40                  45              


Pro Glu Leu Trp Thr Glu Leu Thr Gly Leu Ala Ala Ser Ser Glu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Glu Gly Ala Ala Glu Gly Arg Ala Ala Ala Val Ser 
65                  70                  75                  80  


Leu Glu Glu Ala Leu Leu Arg Leu Ala Glu Phe Leu Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Glu Glu Ser Cys Gly Gly Pro Ala Asp Leu Gly Gln Ser Gly 
            100                 105                 110         


Glu Val Pro Ser Leu Leu Thr Val Thr Ser Gln Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala Trp Leu Arg Ser Pro Arg Gly Arg Gln Ala Leu Leu Gln Gly Thr 
    130                 135                 140                 


Gln Pro Ala Pro Arg Val Arg Pro Pro Ser Pro Asp Gly Ser Thr Ser 
145                 150                 155                 160 


Gln Glu Glu Ser Pro Ser His Phe Thr Ala Val Pro Gly Glu Pro Leu 
                165                 170                 175     


Gly Asp Glu Thr Gln Gly Gln Gln Pro Leu Gln Leu Glu Glu Asp Gln 
            180                 185                 190         


Arg Ala Trp Gln Arg Leu Glu Gln Leu Ile Leu Gly Gln Leu Glu Glu 
        195                 200                 205             


Leu Lys Gln Gln Leu Glu Gln Gln Glu Glu Glu Leu Gly Arg Leu Arg 
    210                 215                 220                 


Leu Gly Val Gly Ala Thr Asp Ser Glu Lys Arg Val Gln His Leu Thr 
225                 230                 235                 240 


Leu Glu Asn Glu Ala Leu Lys Gln Ser Leu Ser Leu Met Arg Asp Leu 
                245                 250                 255     


Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala Pro Gln Glu Glu 
            260                 265                 270         


Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln Glu Ala Gln Asp 
        275                 280                 285             


Thr Thr Glu Ala Leu Arg Ala Gln Leu Gly Val Gln Glu Val Gln Leu 
    290                 295                 300                 


Gln Gly Leu Gln Gly Ala Leu Gln Gln Leu Gln Gln Glu Thr Glu Gln 
305                 310                 315                 320 


Asn Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln Leu Ala Gly Leu 
                325                 330                 335     


Arg Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly Asp Leu Arg Gly 
            340                 345                 350         


Leu Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser Leu Ser Glu Ala 
        355                 360                 365             


Arg Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser Ser Gly Gly Pro 
    370                 375                 380                 


Gly Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro Ala Gly Cys Pro 
385                 390                 395                 400 


Gly Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val Leu Cys Arg Leu 
                405                 410                 415     


Arg Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu Pro Gly Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg Arg Phe Arg Leu 
        435                 440                 445             


Asp Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu Val Phe Arg Glu 
    450                 455                 460                 


Leu Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr Ser Val Cys Ile 
465                 470                 475                 480 


Phe Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr Ser Met Glu Gly 
                485                 490                 495     


Pro Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu Gln Ser Leu Phe 
            500                 505                 510         


Arg Glu Met Gly Ala Gly Arg Gln His Arg Val Thr Leu Ser Met Val 
        515                 520                 525             


Glu Ile Tyr Asn Glu Ala Val Arg Asp Leu Leu Ala Pro Gly Pro Pro 
    530                 535                 540                 


Glu Arg Leu Ala Val Arg Gln Gly Pro Glu Gly Gln Gly Gly Ile Gln 
545                 550                 555                 560 


Val Ala Gly Leu Thr His Trp Asp Val Pro Asn Leu Glu Thr Leu His 
                565                 570                 575     


Gln Met Leu Lys Leu Gly Arg Ser Asn Arg Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Met Asn Gln Arg Ser Ser Arg Ser His Ala Leu Val Thr Leu Thr Leu 
        595                 600                 605             


Arg Ala Ala Ser Pro Pro Arg Ala Pro Gly Thr Ala Gly Thr Leu His 
    610                 615                 620                 


Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Arg Lys Ala Gly Ala Ala 
625                 630                 635                 640 


Gly Pro Pro Arg Gly Asp Pro Asp Gly Ala Arg Arg Leu Arg Glu Ala 
                645                 650                 655     


Gln Thr Ile Asn Arg Ser Leu Leu Ala Leu Gly Gly Val Met Ala Ala 
            660                 665                 670         


Leu Arg Ala His Arg Pro His Val Pro Phe Arg Asp Ser Gln Leu Thr 
        675                 680                 685             


Arg Leu Leu Gln Pro Ala Leu Gly Pro Gly Thr Thr Ala Val Leu Leu 
    690                 695                 700                 


Leu Gln Val Gly Ala Gly Ala Gly Gln Val Cys Ala Cys Arg Ser Pro 
705                 710                 715                 720 


Pro Thr Arg Ala Arg Pro Pro Ala Pro Leu Ala Arg Arg Ser Pro Arg 
                725                 730                 735     


Gly Arg Arg Ile Ser Gly Arg Gln Ser Ala Pro Ser Ser Ser Pro Thr 
            740                 745                 750         


Glu Trp Val Lys Trp Ser Trp Gly Gln Pro Gly Ala Ala Gly Ser Arg 
        755                 760                 765             


Ala Pro Pro Gly Arg Leu Leu Pro Ser Ala Pro Thr Leu Arg Ser Pro 
    770                 775                 780                 


Gly Pro Pro Ala Pro Leu Arg Arg Pro Leu Ala Val Leu His Ala Pro 
785                 790                 795                 800 


Val Pro Thr Thr Ala Arg Ala Arg Leu Ser Arg Pro Gln Arg Ala Cys 
                805                 810                 815     


Pro Ser Ser Pro Gly Ser Arg Pro Cys Pro Trp Gly Leu Arg Pro Gly 
            820                 825                 830         


Leu Cys Trp Gln Arg Arg 
        835             


<210>  321
<211>  1749
<212>  DNA
<213>  Homo sapiens

<400>  321
atggctgcac ggagctggca ggacgagctg gcccagcagg ccgaggaggg ctcggcccgg       60

ctgcgggaaa tgctctcggt cggcctaggc tttctgcgca ccgagctggg cctcgacctg      120

gggctggagc cgaaacggta ccccggctgg gtgatcctgg tgggcactgg cgcgctcggg      180

ctgctgctgc tgtttctgct gggctacggc tgggccgcgg cttgcgccgg cgcccgcaaa      240

aagcggagga gcccgccccg caagcgggag gaggcggcgg ccgtgccggc cgcggccccc      300

gacgacctgg ccttgctgaa gaatctccgg agcgaggaac agaagaagaa gaaccggaag      360

aaactgtccg agaagcccaa accaaatggg cggactgttg aagtggctga gggtgaagct      420

gttcgaacac ctcaaagtgt aacagcaaag cagccaccag agattgacaa gaaaaatgaa      480

aagtcaaaga aaaataagaa gaaatcaaag tcagatgcta aagcagtgca aaacagttca      540

cgccatgatg gaaaggaagt tgatgaagga gcctgggaaa ctaaaattag tcacagagag      600

aaacgacagc agcgtaaacg tgataaggtg ctgactgatt ctggttcatt ggattcaact      660

atccctggga tagaaaatac catcacagtt accaccgagc aacttacaac cgcatcattt      720

cctgttggtt ccaagaagaa taaaggtgat tctcatctaa atgttcaagt tagcaacttt      780

aaatctggaa aaggagattc tacacttcag gtttcttcag gattgaatga aaacctcact      840

gtcaatggag gaggctggaa tgaaaagtct gtaaaactct cctcacagat cagtgcaggt      900

gaggagaagt ggaactccgt ttcacctgct tctgcaggaa agaggaaaac tgagccatct      960

gcctggagtc aagacactgg agatgctaat acaaatggaa aagactgggg aaggagttgg     1020

agtgaccgtt caatattttc tggcattggg tctactgctg agccagtttc tcagtctacc     1080

acttctgatt atcagtggga tgttagccgt aatcaaccct atatcgatga tgaatggtct     1140

gggttaaatg gtctgtcttc tgctgatccc aactctgatt ggaatgcacc agcagaagag     1200

tggggcaatt gggtagacga agaaagagct tcacttctaa agtcccagga accaattcct     1260

gatgatcaaa aggtctcaga tgatgataaa gaaaagggag agggagctct tccaactggg     1320

aaatccaaaa agaaaaaaaa gaaaaagaag aagcaaggtg aagataactc tactgcacag     1380

gacacagaag aattagaaaa agagattaga gaagaccttc cagtgaatac ctctaaaacc     1440

cgtccaaaac aggaaaaagc tttttccttg aagaccataa gcactagtga tccagccgaa     1500

gtactcgtca aaaatagcca gcctatcaag actcttccac ctgctacttc taccgagcca     1560

tctgtaatct tatcaaaaag tgattctgac aagagctctt cccaagtgcc gccaatacta     1620

caagagacag ataaatccaa gtcaaatacc aagcaaaata gtgtgcctcc ttcacagacc     1680

aagtctgaaa ctagctggga atctcccaaa caaataaaaa agaagaaaaa agccagacga     1740

gaaacgtga                                                             1749


<210>  322
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Ala Ala Arg Ser Trp Gln Asp Glu Leu Ala Gln Gln Ala Glu Glu 
1               5                   10                  15      


Gly Ser Ala Arg Leu Arg Glu Met Leu Ser Val Gly Leu Gly Phe Leu 
            20                  25                  30          


Arg Thr Glu Leu Gly Leu Asp Leu Gly Leu Glu Pro Lys Arg Tyr Pro 
        35                  40                  45              


Gly Trp Val Ile Leu Val Gly Thr Gly Ala Leu Gly Leu Leu Leu Leu 
    50                  55                  60                  


Phe Leu Leu Gly Tyr Gly Trp Ala Ala Ala Cys Ala Gly Ala Arg Lys 
65                  70                  75                  80  


Lys Arg Arg Ser Pro Pro Arg Lys Arg Glu Glu Ala Ala Ala Val Pro 
                85                  90                  95      


Ala Ala Ala Pro Asp Asp Leu Ala Leu Leu Lys Asn Leu Arg Ser Glu 
            100                 105                 110         


Glu Gln Lys Lys Lys Asn Arg Lys Lys Leu Ser Glu Lys Pro Lys Pro 
        115                 120                 125             


Asn Gly Arg Thr Val Glu Val Ala Glu Gly Glu Ala Val Arg Thr Pro 
    130                 135                 140                 


Gln Ser Val Thr Ala Lys Gln Pro Pro Glu Ile Asp Lys Lys Asn Glu 
145                 150                 155                 160 


Lys Ser Lys Lys Asn Lys Lys Lys Ser Lys Ser Asp Ala Lys Ala Val 
                165                 170                 175     


Gln Asn Ser Ser Arg His Asp Gly Lys Glu Val Asp Glu Gly Ala Trp 
            180                 185                 190         


Glu Thr Lys Ile Ser His Arg Glu Lys Arg Gln Gln Arg Lys Arg Asp 
        195                 200                 205             


Lys Val Leu Thr Asp Ser Gly Ser Leu Asp Ser Thr Ile Pro Gly Ile 
    210                 215                 220                 


Glu Asn Thr Ile Thr Val Thr Thr Glu Gln Leu Thr Thr Ala Ser Phe 
225                 230                 235                 240 


Pro Val Gly Ser Lys Lys Asn Lys Gly Asp Ser His Leu Asn Val Gln 
                245                 250                 255     


Val Ser Asn Phe Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser 
            260                 265                 270         


Ser Gly Leu Asn Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu 
        275                 280                 285             


Lys Ser Val Lys Leu Ser Ser Gln Ile Ser Ala Gly Glu Glu Lys Trp 
    290                 295                 300                 


Asn Ser Val Ser Pro Ala Ser Ala Gly Lys Arg Lys Thr Glu Pro Ser 
305                 310                 315                 320 


Ala Trp Ser Gln Asp Thr Gly Asp Ala Asn Thr Asn Gly Lys Asp Trp 
                325                 330                 335     


Gly Arg Ser Trp Ser Asp Arg Ser Ile Phe Ser Gly Ile Gly Ser Thr 
            340                 345                 350         


Ala Glu Pro Val Ser Gln Ser Thr Thr Ser Asp Tyr Gln Trp Asp Val 
        355                 360                 365             


Ser Arg Asn Gln Pro Tyr Ile Asp Asp Glu Trp Ser Gly Leu Asn Gly 
    370                 375                 380                 


Leu Ser Ser Ala Asp Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu 
385                 390                 395                 400 


Trp Gly Asn Trp Val Asp Glu Glu Arg Ala Ser Leu Leu Lys Ser Gln 
                405                 410                 415     


Glu Pro Ile Pro Asp Asp Gln Lys Val Ser Asp Asp Asp Lys Glu Lys 
            420                 425                 430         


Gly Glu Gly Ala Leu Pro Thr Gly Lys Ser Lys Lys Lys Lys Lys Lys 
        435                 440                 445             


Lys Lys Lys Gln Gly Glu Asp Asn Ser Thr Ala Gln Asp Thr Glu Glu 
    450                 455                 460                 


Leu Glu Lys Glu Ile Arg Glu Asp Leu Pro Val Asn Thr Ser Lys Thr 
465                 470                 475                 480 


Arg Pro Lys Gln Glu Lys Ala Phe Ser Leu Lys Thr Ile Ser Thr Ser 
                485                 490                 495     


Asp Pro Ala Glu Val Leu Val Lys Asn Ser Gln Pro Ile Lys Thr Leu 
            500                 505                 510         


Pro Pro Ala Thr Ser Thr Glu Pro Ser Val Ile Leu Ser Lys Ser Asp 
        515                 520                 525             


Ser Asp Lys Ser Ser Ser Gln Val Pro Pro Ile Leu Gln Glu Thr Asp 
    530                 535                 540                 


Lys Ser Lys Ser Asn Thr Lys Gln Asn Ser Val Pro Pro Ser Gln Thr 
545                 550                 555                 560 


Lys Ser Glu Thr Ser Trp Glu Ser Pro Lys Gln Ile Lys Lys Lys Lys 
                565                 570                 575     


Lys Ala Arg Arg Glu Thr 
            580         


<210>  323
<211>  5598
<212>  DNA
<213>  Homo sapiens

<400>  323
atgtcccaga aatcctggat agaaagcact ttgaccaaga gggaatgtgt atatattata       60

ccaagttcca aggaccctca cagatgcctt ccaggatgtc aaatttgtca gcaactcgtc      120

aggtgttttt gtggtcgctt ggtcaagcaa catgcttgtt ttactgcaag tcttgccatg      180

aaatactcag atgtgaaatt gggtgaccat tttaatcagg caatagaaga atggtctgtg      240

gaaaagcata cagaacagag cccaacggat gcttatggag tcataaattt tcaagggggt      300

tctcattcct acagagctaa gtatgtgagg ctatcatatg acaccaaacc tgaagtcatt      360

ctgcaacttc tgcttaaaga atggcaaatg gagttaccca aacttgttat ctctgtacat      420

gggggcatgc agaaatttga gcttcaccca cgaatcaagc agttgcttgg aaaaggtctt      480

attaaagctg cagttacaac tggagcctgg attttaactg gaggagtaaa cacaggtgtg      540

gcaaaacatg ttggagatgc cctcaaagaa catgcttcca gatcatctcg aaagatttgc      600

actatcggaa tagctccatg gggagtgatt gaaaacagaa atgatcttgt tgggagagat      660

gtggttgctc cttatcaaac cttattgaac cccctgagca aattgaatgt tttgaataat      720

ctgcattccc atttcatatt ggtggatgat ggcactgttg gaaagtatgg ggcggaagtc      780

agactgagaa gagaacttga aaaaactatt aatcagcaaa gaattcatgc taggattggc      840

cagggtgtcc ctgtggtggc acttatattt gagggtgggc caaatgttat cctcacagtt      900

cttgaatacc ttcaggaaag cccccctgtt ccagtagttg tgtgtgaagg aacaggcaga      960

gctgcagatc tgctagcgta tattcataaa caaacagaag aaggagggaa tcttcctgat     1020

gcagcagagc ccgatattat ttccactatc aaaaaaacat ttaactttgg ccagaatgaa     1080

gcacttcatt tatttcaaac actgatggag tgcatgaaaa gaaaggagct tatcactgtt     1140

ttccatattg ggtcagatga acatcaagat atagatgtag caatacttac tgcactgcta     1200

aaaggtacta atgcatctgc atttgaccag cttatcctta cattggcatg ggatagagtt     1260

gacattgcca aaaatcatgt atttgtttat ggacagcagt ggctggttgg atccttggaa     1320

caagctatgc ttgatgctct tgtaatggat agagttgcat ttgtaaaact tcttattgaa     1380

aatggagtaa gcatgcataa attccttacc attccgagac tggaagaact ttacaacact     1440

aaacaaggtc caactaatcc aatgctgttt catcttgttc gagacgtcaa acagggaaat     1500

cttcctccag gatataagat cactctgatt gatataggac ttgttattga atatctcatg     1560

ggaggaacct acagatgcac ctatactagg aaacgttttc gattaatata taatagtctt     1620

ggtggaaata atcggaggtc tggccgaaat acctccagca gcactcctca gttgcgaaag     1680

agtcatgaat cttttggcaa tagggcagat aaaaaggaaa aaatgaggca taaccatttc     1740

attaagacag cacagcccta ccgaccaaag attgatacag ttatggaaga aggaaagaag     1800

aaaagaacca aagatgaaat tgtagacatt gatgatccag aaaccaagcg ctttccttat     1860

ccacttaatg aacttttaat ttgggcttgc cttatgaaga ggcaggtcat ggcccgtttt     1920

ttatggcaac atggtgaaga atcaatggct aaagcattag ttgcctgtaa gatctatcgt     1980

tcaatggcat atgaagcaaa gcagagtgac ctggtagatg atacttcaga agaactaaaa     2040

cagtattcca atgattttgg tcagttggcc gttgaattat tagaacagtc cttcagacaa     2100

gatgaaacca tggctatgaa attgctcact tatgaactga agaactggag taattcaacc     2160

tgccttaagt tagcagtttc ttcaagactt agaccttttg tagctcacac ctgtacacaa     2220

atgttgttat ctgatatgtg gatgggaagg ctgaatatga ggaaaaattc ctggtacaag     2280

gtcatactaa gcattttagt tccacctgcc atattgctgt tagagtataa aactaaggct     2340

gaaatgtccc atatcccaca atctcaagat gctcatcaga tgacaatgga tgacagcgaa     2400

aacaactttc agaacataac agaagagatc cccatggaag tgtttaaaga agtacggatt     2460

ttggatagta atgaaggaaa gaatgagatg gagatacaaa tgaaatcaaa aaagcttcca     2520

attacgcgaa agttttatgc cttttatcat gcaccaattg taaaattctg gtttaacacg     2580

ttggcatatt taggatttct gatgctttat acatttgtgg ttcttgtaca aatggaacag     2640

ttaccttcag ttcaagaatg gattgttatt gcttatattt ttacttatgc cattgagaaa     2700

gtccgtgaga tctttatgtc tgaagctggg aaagtaaacc agaagattaa agtatggttt     2760

agtgattact tcaacatcag tgatacaatt gccataattt ctttcttcat tggatttgga     2820

ctaagatttg gagcaaaatg gaactttgca aatgcatatg ataatcatgt ttttgtggct     2880

ggaagattaa tttactgtct taacataata ttttggtatg tgcgtttgct agattttcta     2940

gctgtaaatc aacaggcagg accttatgta atgatgattg gaaaaatggt ggccaatatg     3000

ttctacattg tagtgattat ggctcttgta ttacttagtt ttggtgttcc cagaaaggca     3060

atactttatc ctcatgaagc accatcttgg actcttgcta aagatatagt ttttcaccca     3120

tactggatga tttttggtga agtttatgca tacgaaattg atgtgtgtgc aaatgattct     3180

gttatccctc aaatctgtgg tcctgggacg tggttgactc catttcttca agcagtctac     3240

ctctttgtac agtatatcat tatggttaat cttcttattg catttttcaa caatgtgtat     3300

ttacaagtga aggcaatttc caatattgta tggaagtacc agcgttatca ttttattatg     3360

gcttatcatg agaaaccagt tctgcctcct ccacttatca ttcttagcca tatagtttct     3420

ctgttttgct gcatatgtaa gagaagaaag aaagataaga cttccgatgg accaaaactt     3480

ttcttaacag aagaagatca aaagaaactt catgattttg aagagcagtg tgttgaaatg     3540

tatttcaatg aaaaagatga caaatttcat tctgggagtg aagagagaat tcgtgtcact     3600

tttgaaagag tggaacagat gtgcattcag attaaagaag ttggagatcg tgtcaactac     3660

ataaaaagat cattacaatc attagattct caaattggcc atttgcaaga tctttcagcc     3720

ctgacggtag atacattaaa aacactcact gcccagaaag cgtcggaagc tagcaaagtt     3780

cataatgaaa tcacacgaga actgagcatt tccaaacact tggctcaaaa ccttattgat     3840

gatggtcctg taagaccttc tgtatggaaa aagcatggtg ttgtaaatac acttagctcc     3900

tctcttcctc aaggtgatct tgaaagtaat aatccttttc attgtaatat tttaatgaaa     3960

gatgacaaag atccccagtg taatatattt ggtcaagact tacctgcagt accccagaga     4020

aaagaattta attttccaga ggctggttcc tcttctggtg ccttattccc aagtgctgtt     4080

tcccctccag aactgcgaca gagactacat ggggtagaac tcttaaaaat atttaataaa     4140

aatcaaaaat taggcagttc atctactagc ataccacatc tgtcatcccc accaaccaaa     4200

ttttttgtta gtacaccatc tcagccaagt tgcaaaagcc acttggaaac tggaaccaaa     4260

gatcaagaaa ctgtttgctc taaagctaca gaaggagata atacagaatt tggagcattt     4320

gtaggacaca gagatagcat ggatttacag aggtttaaag aaacatcaaa caagataaaa     4380

atactatcca ataacaatac ttctgaaaac actttgaaac gagtgagttc tcttgctgga     4440

tttactgact gtcacagaac ttccattcct gttcattcaa aacaagcaga aaaaatcagt     4500

agaaggccat ctaccgaaga cactcatgaa gtagattcca aagcagcttt aataccggat     4560

tggttacaag atagaccatc aaacagagaa atgccatctg aagaaggaac attaaatggt     4620

ctcacttctc catttaagcc agctatggat acaaattact attattcagc tgtggaaaga     4680

aataacttga tgaggttatc acagagcatt ccatttacac ctgtgcctcc aagaggggag     4740

cctgtcacag tgtatcgttt ggaagagagt tcacccaaca tactaaataa cagcatgtct     4800

tcttggtcac aactaggcct ctgtgccaaa atagagtttt taagcaaaga ggagatggga     4860

ggaggtttac gaagagctgt caaagtacag tgtacctggt cagaacatga tatcctcaaa     4920

tcagggcatc tttatattat caaatctttt cttccagagg tggttaatac atggtcaagt     4980

atttacaaag aagatacagt tctgcatctc tgtctgagag aaattcaaca acagagagca     5040

gcacaaaagc ttacgtttgc ctttaatcaa atgaaaccca aatccatacc atattctcca     5100

aggttccttg aagttttcct gctgtattgc cattcagcag gacagtggtt tgctgtggaa     5160

gaatgtatga ctggagaatt tagaaaatac aacaataata atggagatga gattattcca     5220

actaatactc tggaagagat catgctagcc tttagccact ggacttacga atatacaaga     5280

ggggagttac tggtacttga tttgcaaggt gttggtgaaa atttgactga cccatctgtg     5340

ataaaagcag aagaaaagag atcctgtgat atggtttttg gcccagcaaa tctaggagaa     5400

gatgcaatta aaaacttcag agcaaaacat cactgtaatt cttgctgtag aaagcttaaa     5460

cttccagatc tgaagaggaa tgattatacg cctgataaaa ttatatttcc tcaggatgag     5520

ccttcagatt tgaatcttca gcctggaaat tccaccaaag aatcagaatc aactaattct     5580

gttcgtctga tgttataa                                                   5598


<210>  324
<211>  1865
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Ser Gln Lys Ser Trp Ile Glu Ser Thr Leu Thr Lys Arg Glu Cys 
1               5                   10                  15      


Val Tyr Ile Ile Pro Ser Ser Lys Asp Pro His Arg Cys Leu Pro Gly 
            20                  25                  30          


Cys Gln Ile Cys Gln Gln Leu Val Arg Cys Phe Cys Gly Arg Leu Val 
        35                  40                  45              


Lys Gln His Ala Cys Phe Thr Ala Ser Leu Ala Met Lys Tyr Ser Asp 
    50                  55                  60                  


Val Lys Leu Gly Asp His Phe Asn Gln Ala Ile Glu Glu Trp Ser Val 
65                  70                  75                  80  


Glu Lys His Thr Glu Gln Ser Pro Thr Asp Ala Tyr Gly Val Ile Asn 
                85                  90                  95      


Phe Gln Gly Gly Ser His Ser Tyr Arg Ala Lys Tyr Val Arg Leu Ser 
            100                 105                 110         


Tyr Asp Thr Lys Pro Glu Val Ile Leu Gln Leu Leu Leu Lys Glu Trp 
        115                 120                 125             


Gln Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly Gly Met Gln 
    130                 135                 140                 


Lys Phe Glu Leu His Pro Arg Ile Lys Gln Leu Leu Gly Lys Gly Leu 
145                 150                 155                 160 


Ile Lys Ala Ala Val Thr Thr Gly Ala Trp Ile Leu Thr Gly Gly Val 
                165                 170                 175     


Asn Thr Gly Val Ala Lys His Val Gly Asp Ala Leu Lys Glu His Ala 
            180                 185                 190         


Ser Arg Ser Ser Arg Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly 
        195                 200                 205             


Val Ile Glu Asn Arg Asn Asp Leu Val Gly Arg Asp Val Val Ala Pro 
    210                 215                 220                 


Tyr Gln Thr Leu Leu Asn Pro Leu Ser Lys Leu Asn Val Leu Asn Asn 
225                 230                 235                 240 


Leu His Ser His Phe Ile Leu Val Asp Asp Gly Thr Val Gly Lys Tyr 
                245                 250                 255     


Gly Ala Glu Val Arg Leu Arg Arg Glu Leu Glu Lys Thr Ile Asn Gln 
            260                 265                 270         


Gln Arg Ile His Ala Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu 
        275                 280                 285             


Ile Phe Glu Gly Gly Pro Asn Val Ile Leu Thr Val Leu Glu Tyr Leu 
    290                 295                 300                 


Gln Glu Ser Pro Pro Val Pro Val Val Val Cys Glu Gly Thr Gly Arg 
305                 310                 315                 320 


Ala Ala Asp Leu Leu Ala Tyr Ile His Lys Gln Thr Glu Glu Gly Gly 
                325                 330                 335     


Asn Leu Pro Asp Ala Ala Glu Pro Asp Ile Ile Ser Thr Ile Lys Lys 
            340                 345                 350         


Thr Phe Asn Phe Gly Gln Asn Glu Ala Leu His Leu Phe Gln Thr Leu 
        355                 360                 365             


Met Glu Cys Met Lys Arg Lys Glu Leu Ile Thr Val Phe His Ile Gly 
    370                 375                 380                 


Ser Asp Glu His Gln Asp Ile Asp Val Ala Ile Leu Thr Ala Leu Leu 
385                 390                 395                 400 


Lys Gly Thr Asn Ala Ser Ala Phe Asp Gln Leu Ile Leu Thr Leu Ala 
                405                 410                 415     


Trp Asp Arg Val Asp Ile Ala Lys Asn His Val Phe Val Tyr Gly Gln 
            420                 425                 430         


Gln Trp Leu Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val 
        435                 440                 445             


Met Asp Arg Val Ala Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser 
    450                 455                 460                 


Met His Lys Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr 
465                 470                 475                 480 


Lys Gln Gly Pro Thr Asn Pro Met Leu Phe His Leu Val Arg Asp Val 
                485                 490                 495     


Lys Gln Gly Asn Leu Pro Pro Gly Tyr Lys Ile Thr Leu Ile Asp Ile 
            500                 505                 510         


Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Thr Tyr Arg Cys Thr Tyr 
        515                 520                 525             


Thr Arg Lys Arg Phe Arg Leu Ile Tyr Asn Ser Leu Gly Gly Asn Asn 
    530                 535                 540                 


Arg Arg Ser Gly Arg Asn Thr Ser Ser Ser Thr Pro Gln Leu Arg Lys 
545                 550                 555                 560 


Ser His Glu Ser Phe Gly Asn Arg Ala Asp Lys Lys Glu Lys Met Arg 
                565                 570                 575     


His Asn His Phe Ile Lys Thr Ala Gln Pro Tyr Arg Pro Lys Ile Asp 
            580                 585                 590         


Thr Val Met Glu Glu Gly Lys Lys Lys Arg Thr Lys Asp Glu Ile Val 
        595                 600                 605             


Asp Ile Asp Asp Pro Glu Thr Lys Arg Phe Pro Tyr Pro Leu Asn Glu 
    610                 615                 620                 


Leu Leu Ile Trp Ala Cys Leu Met Lys Arg Gln Val Met Ala Arg Phe 
625                 630                 635                 640 


Leu Trp Gln His Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys 
                645                 650                 655     


Lys Ile Tyr Arg Ser Met Ala Tyr Glu Ala Lys Gln Ser Asp Leu Val 
            660                 665                 670         


Asp Asp Thr Ser Glu Glu Leu Lys Gln Tyr Ser Asn Asp Phe Gly Gln 
        675                 680                 685             


Leu Ala Val Glu Leu Leu Glu Gln Ser Phe Arg Gln Asp Glu Thr Met 
    690                 695                 700                 


Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr 
705                 710                 715                 720 


Cys Leu Lys Leu Ala Val Ser Ser Arg Leu Arg Pro Phe Val Ala His 
                725                 730                 735     


Thr Cys Thr Gln Met Leu Leu Ser Asp Met Trp Met Gly Arg Leu Asn 
            740                 745                 750         


Met Arg Lys Asn Ser Trp Tyr Lys Val Ile Leu Ser Ile Leu Val Pro 
        755                 760                 765             


Pro Ala Ile Leu Leu Leu Glu Tyr Lys Thr Lys Ala Glu Met Ser His 
    770                 775                 780                 


Ile Pro Gln Ser Gln Asp Ala His Gln Met Thr Met Asp Asp Ser Glu 
785                 790                 795                 800 


Asn Asn Phe Gln Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys 
                805                 810                 815     


Glu Val Arg Ile Leu Asp Ser Asn Glu Gly Lys Asn Glu Met Glu Ile 
            820                 825                 830         


Gln Met Lys Ser Lys Lys Leu Pro Ile Thr Arg Lys Phe Tyr Ala Phe 
        835                 840                 845             


Tyr His Ala Pro Ile Val Lys Phe Trp Phe Asn Thr Leu Ala Tyr Leu 
    850                 855                 860                 


Gly Phe Leu Met Leu Tyr Thr Phe Val Val Leu Val Gln Met Glu Gln 
865                 870                 875                 880 


Leu Pro Ser Val Gln Glu Trp Ile Val Ile Ala Tyr Ile Phe Thr Tyr 
                885                 890                 895     


Ala Ile Glu Lys Val Arg Glu Ile Phe Met Ser Glu Ala Gly Lys Val 
            900                 905                 910         


Asn Gln Lys Ile Lys Val Trp Phe Ser Asp Tyr Phe Asn Ile Ser Asp 
        915                 920                 925             


Thr Ile Ala Ile Ile Ser Phe Phe Ile Gly Phe Gly Leu Arg Phe Gly 
    930                 935                 940                 


Ala Lys Trp Asn Phe Ala Asn Ala Tyr Asp Asn His Val Phe Val Ala 
945                 950                 955                 960 


Gly Arg Leu Ile Tyr Cys Leu Asn Ile Ile Phe Trp Tyr Val Arg Leu 
                965                 970                 975     


Leu Asp Phe Leu Ala Val Asn Gln Gln Ala Gly Pro Tyr Val Met Met 
            980                 985                 990         


Ile Gly Lys Met Val Ala Asn Met  Phe Tyr Ile Val Val  Ile Met Ala 
        995                 1000                 1005             


Leu Val  Leu Leu Ser Phe Gly  Val Pro Arg Lys Ala  Ile Leu Tyr 
    1010                 1015                 1020             


Pro His  Glu Ala Pro Ser Trp  Thr Leu Ala Lys Asp  Ile Val Phe 
    1025                 1030                 1035             


His Pro  Tyr Trp Met Ile Phe  Gly Glu Val Tyr Ala  Tyr Glu Ile 
    1040                 1045                 1050             


Asp Val  Cys Ala Asn Asp Ser  Val Ile Pro Gln Ile  Cys Gly Pro 
    1055                 1060                 1065             


Gly Thr  Trp Leu Thr Pro Phe  Leu Gln Ala Val Tyr  Leu Phe Val 
    1070                 1075                 1080             


Gln Tyr  Ile Ile Met Val Asn  Leu Leu Ile Ala Phe  Phe Asn Asn 
    1085                 1090                 1095             


Val Tyr  Leu Gln Val Lys Ala  Ile Ser Asn Ile Val  Trp Lys Tyr 
    1100                 1105                 1110             


Gln Arg  Tyr His Phe Ile Met  Ala Tyr His Glu Lys  Pro Val Leu 
    1115                 1120                 1125             


Pro Pro  Pro Leu Ile Ile Leu  Ser His Ile Val Ser  Leu Phe Cys 
    1130                 1135                 1140             


Cys Ile  Cys Lys Arg Arg Lys  Lys Asp Lys Thr Ser  Asp Gly Pro 
    1145                 1150                 1155             


Lys Leu  Phe Leu Thr Glu Glu  Asp Gln Lys Lys Leu  His Asp Phe 
    1160                 1165                 1170             


Glu Glu  Gln Cys Val Glu Met  Tyr Phe Asn Glu Lys  Asp Asp Lys 
    1175                 1180                 1185             


Phe His  Ser Gly Ser Glu Glu  Arg Ile Arg Val Thr  Phe Glu Arg 
    1190                 1195                 1200             


Val Glu  Gln Met Cys Ile Gln  Ile Lys Glu Val Gly  Asp Arg Val 
    1205                 1210                 1215             


Asn Tyr  Ile Lys Arg Ser Leu  Gln Ser Leu Asp Ser  Gln Ile Gly 
    1220                 1225                 1230             


His Leu  Gln Asp Leu Ser Ala  Leu Thr Val Asp Thr  Leu Lys Thr 
    1235                 1240                 1245             


Leu Thr  Ala Gln Lys Ala Ser  Glu Ala Ser Lys Val  His Asn Glu 
    1250                 1255                 1260             


Ile Thr  Arg Glu Leu Ser Ile  Ser Lys His Leu Ala  Gln Asn Leu 
    1265                 1270                 1275             


Ile Asp  Asp Gly Pro Val Arg  Pro Ser Val Trp Lys  Lys His Gly 
    1280                 1285                 1290             


Val Val  Asn Thr Leu Ser Ser  Ser Leu Pro Gln Gly  Asp Leu Glu 
    1295                 1300                 1305             


Ser Asn  Asn Pro Phe His Cys  Asn Ile Leu Met Lys  Asp Asp Lys 
    1310                 1315                 1320             


Asp Pro  Gln Cys Asn Ile Phe  Gly Gln Asp Leu Pro  Ala Val Pro 
    1325                 1330                 1335             


Gln Arg  Lys Glu Phe Asn Phe  Pro Glu Ala Gly Ser  Ser Ser Gly 
    1340                 1345                 1350             


Ala Leu  Phe Pro Ser Ala Val  Ser Pro Pro Glu Leu  Arg Gln Arg 
    1355                 1360                 1365             


Leu His  Gly Val Glu Leu Leu  Lys Ile Phe Asn Lys  Asn Gln Lys 
    1370                 1375                 1380             


Leu Gly  Ser Ser Ser Thr Ser  Ile Pro His Leu Ser  Ser Pro Pro 
    1385                 1390                 1395             


Thr Lys  Phe Phe Val Ser Thr  Pro Ser Gln Pro Ser  Cys Lys Ser 
    1400                 1405                 1410             


His Leu  Glu Thr Gly Thr Lys  Asp Gln Glu Thr Val  Cys Ser Lys 
    1415                 1420                 1425             


Ala Thr  Glu Gly Asp Asn Thr  Glu Phe Gly Ala Phe  Val Gly His 
    1430                 1435                 1440             


Arg Asp  Ser Met Asp Leu Gln  Arg Phe Lys Glu Thr  Ser Asn Lys 
    1445                 1450                 1455             


Ile Lys  Ile Leu Ser Asn Asn  Asn Thr Ser Glu Asn  Thr Leu Lys 
    1460                 1465                 1470             


Arg Val  Ser Ser Leu Ala Gly  Phe Thr Asp Cys His  Arg Thr Ser 
    1475                 1480                 1485             


Ile Pro  Val His Ser Lys Gln  Ala Glu Lys Ile Ser  Arg Arg Pro 
    1490                 1495                 1500             


Ser Thr  Glu Asp Thr His Glu  Val Asp Ser Lys Ala  Ala Leu Ile 
    1505                 1510                 1515             


Pro Asp  Trp Leu Gln Asp Arg  Pro Ser Asn Arg Glu  Met Pro Ser 
    1520                 1525                 1530             


Glu Glu  Gly Thr Leu Asn Gly  Leu Thr Ser Pro Phe  Lys Pro Ala 
    1535                 1540                 1545             


Met Asp  Thr Asn Tyr Tyr Tyr  Ser Ala Val Glu Arg  Asn Asn Leu 
    1550                 1555                 1560             


Met Arg  Leu Ser Gln Ser Ile  Pro Phe Thr Pro Val  Pro Pro Arg 
    1565                 1570                 1575             


Gly Glu  Pro Val Thr Val Tyr  Arg Leu Glu Glu Ser  Ser Pro Asn 
    1580                 1585                 1590             


Ile Leu  Asn Asn Ser Met Ser  Ser Trp Ser Gln Leu  Gly Leu Cys 
    1595                 1600                 1605             


Ala Lys  Ile Glu Phe Leu Ser  Lys Glu Glu Met Gly  Gly Gly Leu 
    1610                 1615                 1620             


Arg Arg  Ala Val Lys Val Gln  Cys Thr Trp Ser Glu  His Asp Ile 
    1625                 1630                 1635             


Leu Lys  Ser Gly His Leu Tyr  Ile Ile Lys Ser Phe  Leu Pro Glu 
    1640                 1645                 1650             


Val Val  Asn Thr Trp Ser Ser  Ile Tyr Lys Glu Asp  Thr Val Leu 
    1655                 1660                 1665             


His Leu  Cys Leu Arg Glu Ile  Gln Gln Gln Arg Ala  Ala Gln Lys 
    1670                 1675                 1680             


Leu Thr  Phe Ala Phe Asn Gln  Met Lys Pro Lys Ser  Ile Pro Tyr 
    1685                 1690                 1695             


Ser Pro  Arg Phe Leu Glu Val  Phe Leu Leu Tyr Cys  His Ser Ala 
    1700                 1705                 1710             


Gly Gln  Trp Phe Ala Val Glu  Glu Cys Met Thr Gly  Glu Phe Arg 
    1715                 1720                 1725             


Lys Tyr  Asn Asn Asn Asn Gly  Asp Glu Ile Ile Pro  Thr Asn Thr 
    1730                 1735                 1740             


Leu Glu  Glu Ile Met Leu Ala  Phe Ser His Trp Thr  Tyr Glu Tyr 
    1745                 1750                 1755             


Thr Arg  Gly Glu Leu Leu Val  Leu Asp Leu Gln Gly  Val Gly Glu 
    1760                 1765                 1770             


Asn Leu  Thr Asp Pro Ser Val  Ile Lys Ala Glu Glu  Lys Arg Ser 
    1775                 1780                 1785             


Cys Asp  Met Val Phe Gly Pro  Ala Asn Leu Gly Glu  Asp Ala Ile 
    1790                 1795                 1800             


Lys Asn  Phe Arg Ala Lys His  His Cys Asn Ser Cys  Cys Arg Lys 
    1805                 1810                 1815             


Leu Lys  Leu Pro Asp Leu Lys  Arg Asn Asp Tyr Thr  Pro Asp Lys 
    1820                 1825                 1830             


Ile Ile  Phe Pro Gln Asp Glu  Pro Ser Asp Leu Asn  Leu Gln Pro 
    1835                 1840                 1845             


Gly Asn  Ser Thr Lys Glu Ser  Glu Ser Thr Asn Ser  Val Arg Leu 
    1850                 1855                 1860             


Met Leu  
    1865 


<210>  325
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  325
atggccaagg actttcaaga tatccagcag ctgagctcgg aggaaaatga ccatcctttc       60

catcaaggtg aggggccagg cactcgcagg ctgaatccca ggagaggaaa tccatttttg      120

aaagggccac ctcctgccca gcccctggca cagcgtctct gctccatggt ctgcttcagt      180

ctgcttgccc tgagcttcaa catcctgctg ctggtggtca tctgtgtgac tgggtcccaa      240

agtgagggtc acagaggtgc acagctgcaa gccgagctgc ggagcctgaa ggaagctttc      300

agcaacttct cctcgagcac cctgacggag gtccaggcaa tcagcaccca cggaggcagc      360

gtgggtgaca agatcacatc cctaggagcc aagctggaga aacagcagca ggacctgaaa      420

gcagatcacg atgccctgct cttccatctg aagcacttcc ccgtggacct gcgcttcgtg      480

gcctgccaga tggagctcct ccacagcaac ggctcccaaa ggacctgctg ccccgtcaac      540

tgggtggagc accaaggcag ctgctactgg ttctctcact ccgggaaggc ctgggctgag      600

gcggagaagt actgccagct ggagaacgca cacctggtgg tcatcaactc ctgggaggag      660

cagaaattca ttgtacaaca cacgaacccc ttcaatacct ggataggtct cacggacagt      720

gatggctctt ggaaatgggt ggatggcaca gactataggc acaactacaa gaactgggct      780

gtcactcagc cagataattg gcacgggcac gagctgggtg gaagtgaaga ctgtgttgaa      840

gtccagccgg atggccgctg gaacgatgac ttctgcctgc aggtgtaccg ctgggtgtgt      900

gagaaaaggc ggaatgccac cggcgaggtg gcctga                                936


<210>  326
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
1               5                   10                  15      


Asp His Pro Phe His Gln Gly Glu Gly Pro Gly Thr Arg Arg Leu Asn 
            20                  25                  30          


Pro Arg Arg Gly Asn Pro Phe Leu Lys Gly Pro Pro Pro Ala Gln Pro 
        35                  40                  45              


Leu Ala Gln Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu 
    50                  55                  60                  


Ser Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Thr Gly Ser Gln 
65                  70                  75                  80  


Ser Glu Gly His Arg Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu 
                85                  90                  95      


Lys Glu Ala Phe Ser Asn Phe Ser Ser Ser Thr Leu Thr Glu Val Gln 
            100                 105                 110         


Ala Ile Ser Thr His Gly Gly Ser Val Gly Asp Lys Ile Thr Ser Leu 
        115                 120                 125             


Gly Ala Lys Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp 
    130                 135                 140                 


Ala Leu Leu Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val 
145                 150                 155                 160 


Ala Cys Gln Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Thr Cys 
                165                 170                 175     


Cys Pro Val Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser 
            180                 185                 190         


His Ser Gly Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu 
        195                 200                 205             


Asn Ala His Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile 
    210                 215                 220                 


Val Gln His Thr Asn Pro Phe Asn Thr Trp Ile Gly Leu Thr Asp Ser 
225                 230                 235                 240 


Asp Gly Ser Trp Lys Trp Val Asp Gly Thr Asp Tyr Arg His Asn Tyr 
                245                 250                 255     


Lys Asn Trp Ala Val Thr Gln Pro Asp Asn Trp His Gly His Glu Leu 
            260                 265                 270         


Gly Gly Ser Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn 
        275                 280                 285             


Asp Asp Phe Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg 
    290                 295                 300                 


Asn Ala Thr Gly Glu Val Ala 
305                 310     


<210>  327
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  327
atggcacata cttttagagg atgctcattg gcatttatgt ttataatcac gtggctgttg       60

attaaagcaa aaatagatgc gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta      120

attttacttg gatccactgt caatattaca tgctctttga agcccagaca aggctgcttt      180

cactattcca gacgtaacaa gttaatcctg tacaagtttg acagaagaat caattttcac      240

catggccact ccctcaattc tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc      300

tgcaaactgg cctgtatcaa tagtgatgaa attcaaatat gtggagcaga gatcttcgtt      360

ggtgttgctc cagaacagcc tcaaaattta tcctgcatac agaagggaga acaggggact      420

gtggcctgca cctgggaaag aggacgagac acccacttat acactgagta tactctacag      480

ctaagtggac caaaaaattt aacctggcag aagcaatgta aagacattta ttgtgactat      540

ttggactttg gaatcaacct cacccctgaa tcacctgaat ccaatttcac agccaaggtt      600

actgctgtca atagtcttgg aagctcctct tcacttccat ccacattcac attcttggac      660

atagtgaggc ctcttcctcc gtgggacatt agaatcaaat ttcaaaaggc ttctgtgagc      720

agatgtaccc tttattggag agatgaggga ctggtactgc ttaatcgact cagatatcgg      780

cccagtaaca gcaggctctg gaatatggtt aatgttacaa aggccaaagg aagacatgat      840

ttgctggatc tgaaaccatt tacagaatat gaatttcaga tttcctctaa gctacatctt      900

tataagggaa gttggagtga ttggagtgaa tcattgagag cacaaacacc agaagaagag      960

cctactggga tgttagatgt ctggtacatg aaacggcaca ttgactacag tagacaacag     1020

atttctcttt tctggaagaa tctgagtgtc tcagaggcaa gaggaaaaat tctccactat     1080

caggtgacct tgcaggagct gacaggaggg aaagccatga cacagaacat cacaggacac     1140

acctcctgga ccacagtcat tcctagaacc ggaaattggg ctgtggctgt gtctgcagca     1200

aattcaaaag gcagttctct gcccactcgt attaacataa tgaacctgtg tgaggcaggg     1260

ttgctggctc ctcgccaggt ctctgcaaac tcagagggca tggacaacat tctggtgact     1320

tggcagcctc ccaggaaaga tccctctgct gttcaggagt acgtggtgga atggagagag     1380

ctccatccag ggggtgacac acaggtccct ctaaactggc tacggagtcg accctacaat     1440

gtgtctgctc tgatttcaga gaacataaaa tcctacatct gttatgaaat ccgtgtgtat     1500

gcactctcag gggatcaagg aggatgcagc tccatcctgg gtaactctaa gcacaaagca     1560

ccactgagtg gcccccacat taatgccatc acagaggaaa aggggagcat tttaatttca     1620

tggaacagca ttccagtcca ggagcaaatg ggctgcctcc tccattatag gatatactgg     1680

aaggaacggg actccaactc ccagcctcag ctctgtgaaa ttccctacag agtctcccaa     1740

aattcacatc caataaacag cctgcagccc cgagtgacat atgtcctgtg gatgacagct     1800

ctgacagctg ctggtgaaag ttcccacgga aatgagaggg aattttgtct gcaaggtaaa     1860

gccaattgga tggcgtttgt ggcaccaagc atttgcattg ctatcatcat ggtgggcatt     1920

ttctcaacgc attacttcca gcaaaaggtg tttgttctcc tagcagccct cagacctcag     1980

tggtgtagca gagaaattcc agatccagca aatagcactt gcgctaagaa atatcccatt     2040

gcagaggaga agacacagct gcccttggac aggctcctga tagactggcc cacgcctgaa     2100

gatcctgaac cgctggtcat cagtgaagtc cttcatcaag tgaccccagt tttcagacat     2160

cccccctgct ccaactggcc acaaagggaa aaaggaatcc aaggtcatca ggcctctgag     2220

aaagacatga tgcacagtgc ctcaagccca ccacctccaa gagctctcca agctgagagc     2280

agacaactgg tggatctgta caaggtgctg gagagcaggg gctccgaccc aaagcccgaa     2340

aacccagcct gtccctggac ggtgctccca gcaggtgacc ttcccaccca tgatggctac     2400

ttaccctcca acatagatga cctcccctca catgaggcac ctctcgctga ctctctggaa     2460

gaactggagc ctcagcacat ctccctttct gttttcccct caagttctct tcacccactc     2520

accttctcct gtggtgataa gctgactctg gatcagttaa agatgaggtg tgactccctc     2580

atgctctga                                                             2589


<210>  328
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  329
<211>  273
<212>  DNA
<213>  Homo sapiens

<400>  329
atggatcctc tcagggccca acagctggct gcggagctgg aggtggagat gatggccgat       60

atgtacaaca gaatgaccag tgcctgccac cggaagtgtg tgcctcctca ctacaaggaa      120

gcagagctct ccaagggcga gtctgtgtgc ctggaccgat gtgtctctaa gtacctggac      180

atccatgagc ggatgggcaa aaagttgaca gagttgtcta tgcaggatga agagctgatg      240

aagagggtgc agcagagctc tgggcctgca tga                                   273


<210>  330
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Asp Pro Leu Arg Ala Gln Gln Leu Ala Ala Glu Leu Glu Val Glu 
1               5                   10                  15      


Met Met Ala Asp Met Tyr Asn Arg Met Thr Ser Ala Cys His Arg Lys 
            20                  25                  30          


Cys Val Pro Pro His Tyr Lys Glu Ala Glu Leu Ser Lys Gly Glu Ser 
        35                  40                  45              


Val Cys Leu Asp Arg Cys Val Ser Lys Tyr Leu Asp Ile His Glu Arg 
    50                  55                  60                  


Met Gly Lys Lys Leu Thr Glu Leu Ser Met Gln Asp Glu Glu Leu Met 
65                  70                  75                  80  


Lys Arg Val Gln Gln Ser Ser Gly Pro Ala 
                85                  90  


<210>  331
<211>  5739
<212>  DNA
<213>  Homo sapiens

<400>  331
atggcgtcgg gcctgggctc cccgtccccc tgctcggcgg gcagtgagga ggaggatatg       60

gatgcacttt tgaacaacag cctgccccca ccccacccag aaaatgaaga ggacccagaa      120

gaggatttgt cagaaacaga gactccaaag ctcaagaaga agaaaaagcc taagaaacct      180

cgggacccta aaatccctaa gagcaagcgc caaaaaaagg agcgtatgct cttatgccgg      240

cagctggggg acagctctgg ggaggggcca gagtttgtgg aggaggagga agaggtggct      300

ctgcgctcag acagtgaggg cagcgactat actcctggca agaagaagaa gaagaagctt      360

ggacctaaga aagagaagaa gagcaaatcc aagcggaagg aggaggagga ggaggatgat      420

gatgatgatg attcaaagga gcctaaatca tctgctcagc tcctggaaga ctggggcatg      480

gaagacattg accacgtgtt ctcagaggag gattatcgaa ccctcaccaa ctacaaggcc      540

ttcagccagt ttgtcagacc cctcattgct gccaaaaatc ccaagattgc tgtctccaag      600

atgatgatgg ttttgggtgc aaaatggcgg gagttcagta ccaataaccc cttcaaaggc      660

agttctgggg catcagtggc agctgcggca gcagcagcgg tagctgtggt ggagagcatg      720

gtgacagcca ctgaggttgc accaccacct ccccctgtgg aggtgcctat ccgcaaggcc      780

aagaccaagg agggcaaagg tcccaatgct cggaggaagc ccaagggcag ccctcgtgta      840

cctgatgcca agaagcctaa acccaagaaa gtagctcccc tgaaaatcaa gctgggaggt      900

tttggttcca agcgtaagag atcctcgagt gaggatgatg acttagatgt ggaatctgac      960

ttcgatgatg ccagtatcaa tagctattct gtttctgatg gttccaccag ccgtagtagc     1020

cgcagccgca agaaactccg aaccactaaa aagaaaaaga aaggcgagga ggaggtgact     1080

gctgtggatg gttatgagac agaccaccag gactattgcg aggtgtgcca gcaaggcggt     1140

gagatcatcc tgtgtgatac ctgtccccgt gcttaccaca tggtctgcct ggatcccgac     1200

atggagaagg ctcccgaggg caagtggagc tgcccacact gcgagaagga aggcatccag     1260

tgggaagcta aagaggacaa ttcggagggt gaggagatcc tggaagaggt tgggggagac     1320

ctcgaagagg aggatgacca ccatatggaa ttctgtcggg tctgcaagga tggtggggaa     1380

ctgctctgct gtgatacctg tccttcttcc taccacatcc actgcctgaa tcccccactt     1440

ccagagatcc ccaacggtga atggctctgt ccccgttgta cgtgtccagc tctgaagggc     1500

aaagtgcaga agatcctaat ctggaagtgg ggtcagccac catctcccac accagtgcct     1560

cggcctccag atgctgatcc caacacgccc tccccaaagc ccttggaggg gcggccagag     1620

cggcagttct ttgtgaaatg gcaaggcatg tcttactggc actgctcctg ggtttctgaa     1680

ctgcagctgg agctgcactg tcaggtgatg ttccgaaact atcagcggaa gaatgatatg     1740

gatgagccac cttctgggga ctttggtggt gatgaagaga aaagccgaaa gcgaaagaac     1800

aaggacccta aatttgcaga gatggaggaa cgcttctatc gctatgggat aaaacccgag     1860

tggatgatga tccaccgaat cctcaaccac agtgtggaca agaagggcca cgtccactac     1920

ttgatcaagt ggcgggactt accttacgat caggcttctt gggagagtga ggatgtggag     1980

atccaggatt acgacctgtt caagcagagc tattggaatc acagggagtt aatgaggggt     2040

gaggaaggcc gaccaggcaa gaagctcaag aaggtgaagc ttcggaagtt ggagaggcct     2100

ccagaaacgc caacagttga tccaacagtg aagtatgagc gacagccaga gtacctggat     2160

gctacaggtg gaaccctgca cccctatcaa atggagggcc tgaattggtt gcgcttctcc     2220

tgggctcagg gcactgacac catcttggct gatgagatgg gccttgggaa aactgtacag     2280

acagcagtct tcctgtattc cctttacaag gagggtcatt ccaaaggccc cttcctagtg     2340

agcgcccctc tttctaccat catcaactgg gagcgggagt ttgaaatgtg ggctccagac     2400

atgtatgtcg taacctatgt gggtgacaag gacagccgtg ccatcatccg agagaatgag     2460

ttctcctttg aagacaatgc cattcgtggt ggcaagaagg cctcccgcat gaagaaagag     2520

gcatctgtga aattccatgt gctgctgaca tcctatgaat tgatcaccat tgacatggct     2580

attttgggct ctattgattg ggcctgcctc atcgtggatg aagcccatcg gctgaagaac     2640

aatcagtcta agttcttccg ggtattgaat ggttactcac tccagcacaa gctgttgctg     2700

actgggacac cattacaaaa caatctggaa gagttgtttc atctgctcaa ctttctcacc     2760

cccgagaggt tccacaattt ggaaggtttt ttggaggagt ttgctgacat tgccaaggag     2820

gaccagataa aaaaactgca tgacatgctg gggccgcaca tgttgcggcg gctcaaagcc     2880

gatgtgttca agaacatgcc ctccaagaca gaactaattg tgcgtgtgga gctgagccct     2940

atgcagaaga aatactacaa gtacatcctc actcgaaatt ttgaagcact caatgcccga     3000

ggtggtggca accaggtgtc tctgctgaat gtggtgatgg atcttaagaa gtgctgcaac     3060

catccatacc tcttccctgt ggctgcaatg gaagctccta agatgcctaa tggcatgtat     3120

gatggcagtg ccctaatcag agcatctggg aaattattgc tgctgcagaa aatgctcaag     3180

aaccttaagg agggtgggca tcgtgtactc atcttttccc agatgaccaa gatgctagac     3240

ctgctagagg atttcttgga acatgaaggt tataaatacg aacgcatcga tggtggaatc     3300

actgggaaca tgcggcaaga ggccattgac cgcttcaatg caccgggtgc tcagcagttc     3360

tgcttcttgc tttccactcg agctgggggc cttggaatca atctggccac tgctgacaca     3420

gttattatct atgactctga ctggaacccc cataatgaca ttcaggcctt tagcagagct     3480

caccggattg ggcaaaataa aaaggtaatg atctaccggt ttgtgacccg tgcgtcagtg     3540

gaggagcgca tcacgcaggt ggcaaagaag aaaatgatgc tgacgcatct agtggtgcgg     3600

cctgggctgg gctccaagac tggatctatg tccaaacagg agcttgatga tatcctcaaa     3660

tttggcactg aggaactatt caaggatgaa gccactgatg gaggaggaga caacaaagag     3720

ggagaagata gcagtgttat ccactacgat gataaggcca ttgaacggct gctagaccgt     3780

aaccaggatg agactgaaga cacagaattg cagggcatga atgaatattt gagctcattc     3840

aaagtggccc agtatgtggt acgggaagaa gaaatggggg aggaagagga ggtagaacgg     3900

gaaatcatta aacaggaaga aagtgtggat cctgactact gggagaaatt gctgcggcac     3960

cattatgagc agcagcaaga agatctagcc cgaaatctgg gcaaaggaaa aagaatccgt     4020

aaacaggtca actacaatga tggctcccag gaggaccgag attggcagga cgaccagtcc     4080

gacaaccagt ccgattactc agtggcttca gaggaaggtg atgaagactt tgatgaacgt     4140

tcagaagctc cccgtaggcc cagtcgtaag ggcctgcgga atgataaaga taagccattg     4200

cctcctctgt tggcccgtgt tggtgggaat attgaagtac ttggttttaa tgctcgtcag     4260

cgaaaagcct ttcttaatgc aattatgcga tatggtatgc cacctcagga tgcttttact     4320

acccagtggc ttgtaagaga cctgcgaggc aaatcagaga aagagttcaa ggcatatgtc     4380

tctcttttca tgcggcattt atgtgagccg ggggcagatg gggctgagac ctttgctgat     4440

ggtgtccccc gagaaggcct gtctcgccag catgtcctta ctagaattgg tgttatgtct     4500

ttgattcgca agaaggttca ggagtttgaa catgttaatg ggcgctggag catgcctgaa     4560

ctggctgagg tggaggaaaa caagaagatg tcccagccag ggtcaccctc cccaaaaact     4620

cctacaccct ccactccagg ggacacgcag cccaacactc ctgcacctgt cccacctgct     4680

gaagatggga taaaaataga ggaaaatagc ctcaaagaag aagagagcat agaaggagaa     4740

aaggaggtta aatctacagc ccctgagact gccattgagt gtacacaggc ccctgcccct     4800

gcctcagagg atgaaaaggt cgttgttgaa ccccctgagg gagaggagaa agtggaaaag     4860

gcagaggtga aggagagaac agaggaacct atggagacag agcccaaagg tgctgctgat     4920

gtagagaagg tggaggaaaa gtcagcaata gatctgaccc ctattgtggt agaagacaaa     4980

gaagagaaga aagaagaaga agagaaaaaa gaggtgatgc ttcagaatgg agagaccccc     5040

aaggacctga atgatgagaa acagaagaaa aatattaaac aacgtttcat gtttaacatt     5100

gcagatggtg gttttactga gttgcactcc ctttggcaga atgaagagcg ggcagccaca     5160

gttaccaaga agacttatga gatctggcat cgacggcatg actactggct gctagccggc     5220

attataaacc atggctatgc ccggtggcaa gacatccaga atgacccacg ctatgccatc     5280

ctcaatgagc ctttcaaggg tgaaatgaac cgtggcaatt tcttagagat caagaataaa     5340

tttctagctc gaaggtttaa gctcttagaa caagctctgg tgattgagga acagctgcgc     5400

cgggctgctt acttgaacat gtcagaagac ccttctcacc cttccatggc cctcaacacc     5460

cgctttgctg aggtggagtg tttggcggaa agtcatcagc acctgtccaa ggagtcaatg     5520

gcaggaaaca agccagccaa tgcagtcctg cacaaagttc tgaaacagct ggaagaactg     5580

ctgagtgaca tgaaagctga tgtgactcga ctcccagcta ccattgcccg aattccccca     5640

gttgctgtga ggttacagat gtcagagcgt aacattctca gccgcctggc aaaccgggca     5700

cccgaaccta ccccacagca ggtagcccag cagcagtga                            5739


<210>  332
<211>  1912
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Thr Glu Thr 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Thr Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Thr Leu Thr 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Thr Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Thr Ala Thr Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Thr 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Thr Thr Lys Lys Lys 
            340                 345                 350         


Lys Lys Gly Glu Glu Glu Val Thr Ala Val Asp Gly Tyr Glu Thr Asp 
        355                 360                 365             


His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu 
    370                 375                 380                 


Cys Asp Thr Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp 
385                 390                 395                 400 


Met Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys 
                405                 410                 415     


Glu Gly Ile Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu 
            420                 425                 430         


Ile Leu Glu Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His 
        435                 440                 445             


Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys 
    450                 455                 460                 


Asp Thr Cys Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro 
                485                 490                 495     


Ala Leu Lys Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln 
            500                 505                 510         


Pro Pro Ser Pro Thr Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn 
        515                 520                 525             


Thr Pro Ser Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe 
    530                 535                 540                 


Val Lys Trp Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu 
545                 550                 555                 560 


Leu Gln Leu Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg 
                565                 570                 575     


Lys Asn Asp Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu 
            580                 585                 590         


Glu Lys Ser Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met 
        595                 600                 605             


Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile 
    610                 615                 620                 


His Arg Ile Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr 
625                 630                 635                 640 


Leu Ile Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser 
                645                 650                 655     


Glu Asp Val Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp 
            660                 665                 670         


Asn His Arg Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys 
        675                 680                 685             


Leu Lys Lys Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Thr Pro 
    690                 695                 700                 


Thr Val Asp Pro Thr Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp 
705                 710                 715                 720 


Ala Thr Gly Gly Thr Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp 
                725                 730                 735     


Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu 
            740                 745                 750         


Met Gly Leu Gly Lys Thr Val Gln Thr Ala Val Phe Leu Tyr Ser Leu 
        755                 760                 765             


Tyr Lys Glu Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu 
    770                 775                 780                 


Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp 
785                 790                 795                 800 


Met Tyr Val Val Thr Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile 
                805                 810                 815     


Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys 
            820                 825                 830         


Lys Ala Ser Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu 
        835                 840                 845             


Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp Met Ala Ile Leu Gly Ser 
    850                 855                 860                 


Ile Asp Trp Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn 
865                 870                 875                 880 


Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His 
                885                 890                 895     


Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu 
            900                 905                 910         


Phe His Leu Leu Asn Phe Leu Thr Pro Glu Arg Phe His Asn Leu Glu 
        915                 920                 925             


Gly Phe Leu Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys 
    930                 935                 940                 


Lys Leu His Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala 
945                 950                 955                 960 


Asp Val Phe Lys Asn Met Pro Ser Lys Thr Glu Leu Ile Val Arg Val 
                965                 970                 975     


Glu Leu Ser Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg 
            980                 985                 990         


Asn Phe Glu Ala Leu Asn Ala Arg  Gly Gly Gly Asn Gln  Val Ser Leu 
        995                 1000                 1005             


Leu Asn  Val Val Met Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr 
    1010                 1015                 1020             


Leu Phe  Pro Val Ala Ala Met  Glu Ala Pro Lys Met  Pro Asn Gly 
    1025                 1030                 1035             


Met Tyr  Asp Gly Ser Ala Leu  Ile Arg Ala Ser Gly  Lys Leu Leu 
    1040                 1045                 1050             


Leu Leu  Gln Lys Met Leu Lys  Asn Leu Lys Glu Gly  Gly His Arg 
    1055                 1060                 1065             


Val Leu  Ile Phe Ser Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu 
    1070                 1075                 1080             


Asp Phe  Leu Glu His Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly 
    1085                 1090                 1095             


Gly Ile  Thr Gly Asn Met Arg  Gln Glu Ala Ile Asp  Arg Phe Asn 
    1100                 1105                 1110             


Ala Pro  Gly Ala Gln Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Ile Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile 
    1130                 1135                 1140             


Tyr Asp  Ser Asp Trp Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Asn Lys Lys Val Met  Ile Tyr Arg 
    1160                 1165                 1170             


Phe Val  Thr Arg Ala Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala 
    1175                 1180                 1185             


Lys Lys  Lys Met Met Leu Thr  His Leu Val Val Arg  Pro Gly Leu 
    1190                 1195                 1200             


Gly Ser  Lys Thr Gly Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile 
    1205                 1210                 1215             


Leu Lys  Phe Gly Thr Glu Glu  Leu Phe Lys Asp Glu  Ala Thr Asp 
    1220                 1225                 1230             


Gly Gly  Gly Asp Asn Lys Glu  Gly Glu Asp Ser Ser  Val Ile His 
    1235                 1240                 1245             


Tyr Asp  Asp Lys Ala Ile Glu  Arg Leu Leu Asp Arg  Asn Gln Asp 
    1250                 1255                 1260             


Glu Thr  Glu Asp Thr Glu Leu  Gln Gly Met Asn Glu  Tyr Leu Ser 
    1265                 1270                 1275             


Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg Glu Glu  Glu Met Gly 
    1280                 1285                 1290             


Glu Glu  Glu Glu Val Glu Arg  Glu Ile Ile Lys Gln  Glu Glu Ser 
    1295                 1300                 1305             


Val Asp  Pro Asp Tyr Trp Glu  Lys Leu Leu Arg His  His Tyr Glu 
    1310                 1315                 1320             


Gln Gln  Gln Glu Asp Leu Ala  Arg Asn Leu Gly Lys  Gly Lys Arg 
    1325                 1330                 1335             


Ile Arg  Lys Gln Val Asn Tyr  Asn Asp Gly Ser Gln  Glu Asp Arg 
    1340                 1345                 1350             


Asp Trp  Gln Asp Asp Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val 
    1355                 1360                 1365             


Ala Ser  Glu Glu Gly Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala 
    1370                 1375                 1380             


Pro Arg  Arg Pro Ser Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys 
    1385                 1390                 1395             


Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val 
    1400                 1405                 1410             


Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile 
    1415                 1420                 1425             


Met Arg  Tyr Gly Met Pro Pro  Gln Asp Ala Phe Thr  Thr Gln Trp 
    1430                 1435                 1440             


Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala 
    1445                 1450                 1455             


Tyr Val  Ser Leu Phe Met Arg  His Leu Cys Glu Pro  Gly Ala Asp 
    1460                 1465                 1470             


Gly Ala  Glu Thr Phe Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser 
    1475                 1480                 1485             


Arg Gln  His Val Leu Thr Arg  Ile Gly Val Met Ser  Leu Ile Arg 
    1490                 1495                 1500             


Lys Lys  Val Gln Glu Phe Glu  His Val Asn Gly Arg  Trp Ser Met 
    1505                 1510                 1515             


Pro Glu  Leu Ala Glu Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro 
    1520                 1525                 1530             


Gly Ser  Pro Ser Pro Lys Thr  Pro Thr Pro Ser Thr  Pro Gly Asp 
    1535                 1540                 1545             


Thr Gln  Pro Asn Thr Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly 
    1550                 1555                 1560             


Ile Lys  Ile Glu Glu Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu 
    1565                 1570                 1575             


Gly Glu  Lys Glu Val Lys Ser  Thr Ala Pro Glu Thr  Ala Ile Glu 
    1580                 1585                 1590             


Cys Thr  Gln Ala Pro Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val 
    1595                 1600                 1605             


Val Glu  Pro Pro Glu Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val 
    1610                 1615                 1620             


Lys Glu  Arg Thr Glu Glu Pro  Met Glu Thr Glu Pro  Lys Gly Ala 
    1625                 1630                 1635             


Ala Asp  Val Glu Lys Val Glu  Glu Lys Ser Ala Ile  Asp Leu Thr 
    1640                 1645                 1650             


Pro Ile  Val Val Glu Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu 
    1655                 1660                 1665             


Lys Lys  Glu Val Met Leu Gln  Asn Gly Glu Thr Pro  Lys Asp Leu 
    1670                 1675                 1680             


Asn Asp  Glu Lys Gln Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe 
    1685                 1690                 1695             


Asn Ile  Ala Asp Gly Gly Phe  Thr Glu Leu His Ser  Leu Trp Gln 
    1700                 1705                 1710             


Asn Glu  Glu Arg Ala Ala Thr  Val Thr Lys Lys Thr  Tyr Glu Ile 
    1715                 1720                 1725             


Trp His  Arg Arg His Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn 
    1730                 1735                 1740             


His Gly  Tyr Ala Arg Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr 
    1745                 1750                 1755             


Ala Ile  Leu Asn Glu Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn 
    1760                 1765                 1770             


Phe Leu  Glu Ile Lys Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu 
    1775                 1780                 1785             


Leu Glu  Gln Ala Leu Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala 
    1790                 1795                 1800             


Tyr Leu  Asn Met Ser Glu Asp  Pro Ser His Pro Ser  Met Ala Leu 
    1805                 1810                 1815             


Asn Thr  Arg Phe Ala Glu Val  Glu Cys Leu Ala Glu  Ser His Gln 
    1820                 1825                 1830             


His Leu  Ser Lys Glu Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala 
    1835                 1840                 1845             


Val Leu  His Lys Val Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp 
    1850                 1855                 1860             


Met Lys  Ala Asp Val Thr Arg  Leu Pro Ala Thr Ile  Ala Arg Ile 
    1865                 1870                 1875             


Pro Pro  Val Ala Val Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu 
    1880                 1885                 1890             


Ser Arg  Leu Ala Asn Arg Ala  Pro Glu Pro Thr Pro  Gln Gln Val 
    1895                 1900                 1905             


Ala Gln  Gln Gln 
    1910         


<210>  333
<211>  1233
<212>  DNA
<213>  Homo sapiens

<400>  333
atggtgtgct tccgcctctt cccggttccg ggctcagggc tcgttctggt ctgcctagtc       60

ctgggagctg tgcggtctta tgcattggaa cttaatttga cagattcaga aaatgccact      120

tgcctttatg caaaatggca gatgaatttc acagtacgct atgaaactac aaataaaact      180

tataaaactg taaccatttc agaccatggc actgtgacat ataatggaag catttgtggg      240

gatgatcaga atggtcccaa aatagcagtg cagttcggac ctggcttttc ctggattgcg      300

aattttacca aggcagcatc tacttattca attgacagcg tctcattttc ctacaacact      360

ggtgataaca caacatttcc tgatgctgaa gataaaggaa ttcttactgt tgatgaactt      420

ttggccatca gaattccatt gaatgacctt tttagatgca atagtttatc aactttggaa      480

aagaatgatg ttgtccaaca ctactgggat gttcttgtac aagcttttgt ccaaaatggc      540

acagtgagca caaatgagtt cctgtgtgat aaagacaaaa cttcaacagt ggcacccacc      600

atacacacca ctgtgccatc tcctactaca acacctactc caaaggaaaa accagaagct      660

ggaacctatt cagttaataa tggcaatgat acttgtctgc tggctaccat ggggctgcag      720

ctgaacatca ctcaggataa ggttgcttca gttattaaca tcaaccccaa tacaactcac      780

tccacaggca gctgccgttc tcacactgct ctacttagac tcaatagcag caccattaag      840

tatctagact ttgtctttgc tgtgaaaaat gaaaaccgat tttatctgaa ggaagtgaac      900

atcagcatgt atttggttaa tggctccgtt ttcagcattg caaataacaa tctcagctac      960

tgggatgccc ccctgggaag ttcttatatg tgcaacaaag agcagactgt ttcagtgtct     1020

ggagcatttc agataaatac ctttgatcta agggttcagc ctttcaatgt gacacaagga     1080

aagtattcta cagctcaaga ctgcagtgca gatgacgaca acttccttgt gcccatagcg     1140

gtgggagctg ccttggcagg agtacttatt ctagtgttgc tggcttattt tattggtctc     1200

aagcaccatc atgctggata tgagcaattt tag                                  1233


<210>  334
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  335
<211>  2919
<212>  DNA
<213>  Homo sapiens

<400>  335
atgggcccag gagttctgct gctcctgctg gtggccacag cttggcatgg tcagggaatc       60

ccagtgatag agcccagtgt ccctgagctg gtcgtgaagc caggagcaac ggtgaccttg      120

cgatgtgtgg gcaatggcag cgtggaatgg gatggccccc catcacctca ctggaccctg      180

tactctgatg gctccagcag catcctcagc accaacaacg ctaccttcca aaacacgggg      240

acctatcgct gcactgagcc tggagacccc ctgggaggca gcgccgccat ccacctctat      300

gtcaaagacc ctgcccggcc ctggaacgtg ctagcacagg aggtggtcgt gttcgaggac      360

caggacgcac tactgccctg tctgctcaca gacccggtgc tggaagcagg cgtctcgctg      420

gtgcgtgtgc gtggccggcc cctcatgcgc cacaccaact actccttctc gccctggcat      480

ggcttcacca tccacagggc caagttcatt cagagccagg actatcaatg cagtgccctg      540

atgggtggca ggaaggtgat gtccatcagc atccggctga aagtgcagaa agtcatccca      600

gggcccccag ccttgacact ggtgcctgca gagctggtgc ggattcgagg ggaggctgcc      660

cagatcgtgt gctcagccag cagcgttgat gttaactttg atgtcttcct ccaacacaac      720

aacaccaagc tcgcaatccc tcaacaatct gactttcata ataaccgtta ccaaaaagtc      780

ctgaccctca acctcgatca agtagatttc caacatgccg gcaactactc ctgcgtggcc      840

agcaacgtgc agggcaagca ctccacctcc atgttcttcc gggtggtaga gagtgcctac      900

ttgaacttga gctctgagca gaacctcatc caggaggtga ccgtggggga ggggctcaac      960

ctcaaagtca tggtggaggc ctacccaggc ctgcaaggtt ttaactggac ctacctggga     1020

cccttttctg accaccagcc tgagcccaag cttgctaatg ctaccaccaa ggacacatac     1080

aggcacacct tcaccctctc tctgccccgc ctgaagccct ctgaggctgg ccgctactcc     1140

ttcctggcca gaaacccagg aggctggaga gctctgacgt ttgagctcac ccttcgatac     1200

cccccagagg taagcgtcat atggacattc atcaacggct ctggcaccct tttgtgtgct     1260

gcctctgggt acccccagcc caacgtgaca tggctgcagt gcagtggcca cactgatagg     1320

tgtgatgagg cccaagtgct gcaggtctgg gatgacccat accctgaggt cctgagccag     1380

gagcccttcc acaaggtgac ggtgcagagc ctgctgactg ttgagacctt agagcacaac     1440

caaacctacg agtgcagggc ccacaacagc gtggggagtg gctcctgggc cttcataccc     1500

atctctgcag gagcccacac gcatcccccg gatgagttcc tcttcacacc agtggtggtc     1560

gcctgcatgt ccatcatggc cttgctgctg ctgctgctcc tgctgctatt gtacaagtat     1620

aagcagaagc ccaagtacca ggtccgctgg aagatcatcg agagctatga gggcaacagt     1680

tatactttca tcgaccccac gcagctgcct tacaacgaga agtgggagtt cccccggaac     1740

aacctgcagt ttggtaagac cctcggagct ggagcctttg ggaaggtggt ggaggccacg     1800

gcctttggtc tgggcaagga ggatgctgtc ctgaaggtgg ctgtgaagat gctgaagtcc     1860

acggcccatg ctgatgagaa ggaggccctc atgtccgagc tgaagatcat gagccacctg     1920

ggccagcacg agaacatcgt caaccttctg ggagcctgta cccatggagg ccctgtactg     1980

gtcatcacgg agtactgttg ctatggcgac ctgctcaact ttctgcgaag gaaggctgag     2040

gccatgctgg gacccagcct gagccccggc caggaccccg agggaggcgt cgactataag     2100

aacatccacc tcgagaagaa atatgtccgc agggacagtg gcttctccag ccagggtgtg     2160

gacacctatg tggagatgag gcctgtctcc acttcttcaa atgactcctt ctctgagcaa     2220

gacctggaca aggaggatgg acggcccctg gagctccggg acctgcttca cttctccagc     2280

caagtagccc agggcatggc cttcctcgct tccaagaatt gcatccaccg ggacgtggca     2340

gcgcgtaacg tgctgttgac caatggtcat gtggccaaga ttggggactt cgggctggct     2400

agggacatca tgaatgactc caactacatt gtcaagggca atgcccgcct gcctgtgaag     2460

tggatggccc cagagagcat ctttgactgt gtctacacgg ttcagagcga cgtctggtcc     2520

tatggcatcc tcctctggga gatcttctca cttgggctga atccctaccc tggcatcctg     2580

gtgaacagca agttctataa actggtgaag gatggatacc aaatggccca gcctgcattt     2640

gccccaaaga atatatacag catcatgcag gcctgctggg ccttggagcc cacccacaga     2700

cccaccttcc agcagatctg ctccttcctt caggagcagg cccaagagga caggagagag     2760

cgggactata ccaatctgcc gagcagcagc agaagcggtg gcagcggcag cagcagcagt     2820

gagctggagg aggagagctc tagtgagcac ctgacctgct gcgagcaagg ggatatcgcc     2880

cagcccttgc tgcagcccaa caactatcag ttctgctga                            2919


<210>  336
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  337
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  337
atgctgagga atgagcgaca gttcaaggag gagaagcttg cagagcagct caagcaagct       60

gaggagctca ggcaatataa agtcctggtt cactctcagg aacgagagct gacgcagtta      120

aaggagaagt tacgggaagg gagagatgcc tcccgctcat tgaatgagca tctccaggcc      180

ctcctcactc tggatgagcc ggacaagtcc caggggcagg acctccaaga acagctggct      240

gaggggtgta gactggcaca gcaccttgtc caaaagctca gcccagaaaa tgacgaagat      300

gaggatgaag atgttcaagt tgaggaggat gagaaagtgc agaaatcatc tgcccccagg      360

gaggtgcaga aggctgaagt gagcaaagtc cctgaggact cactggagga atgtgccatc      420

acttgttcaa atagccacgg cccttgtgac tccaaccagc ctcacaagaa catcaaaatc      480

acatttgagg aagacgaagt caactcaact ctggttgtag acagagaatc ctctcatgat      540

gaatgtcagg atgctctaaa cattctccca gtccctggcc ccacctcttc tgccacaaac      600

gtcagcatgg tggtatcagc cggccctttg tccagcgaga aggcagagat gaacattcta      660

gaaatcaatg agaaattgca cccccagctg gcagagaaga aacagcagtt cagaaacctc      720

aaagagaaat gttttctaac tcaactggcc ggcttcctgg ccaaccagca gaacaaatac      780

aaatatgaag agtgcaaaga tctcataaaa tctatgctga ggaatgagcg acagttcaag      840

gaggagaagc ttgcagagca gctcaagcaa gctgaggagc tcaggcaata taaagtcctg      900

gttcacactc aggaacgaga gctgacccag ttaagggaga agttgcggga agggagagat      960

gcctcccgct cattgaatga gcatctccag gccctcctca ctctggatga gccggacaag     1020

tcccaggggc aggacctcca agaacagctg gctgaggggt gtagactggc acagcacctt     1080

gtccaaaagc tcagcccaga aaatgacaac gatgacgatg aagatgttca agttgaggtg     1140

gctgagaaag tgcagaaatc gtctgccccc agggagatgc agaaggctga agaaaaggaa     1200

gtccctgagg actcactgga ggaatgtgcc atcacttatt caaatagcca tggcccttat     1260

gactccaacc agccacatag gaaaaccaaa atcacatttg aggaagacaa agtcgactca     1320

gctctcattg gctcatcctc tcatgttgaa tgggaggatg ctgtacacat tattccagaa     1380

aatgaaagtg atgatgagga agaggaagaa aaagggccag tgtctcccag gaatctgcag     1440

gagtctgaag aggaggaagt cccccaggag tcctgggatg aaggttattc gactctctca     1500

attcctcctg aaatgttggc ctcgtacaag tcttacagca gcacatttca ctcattagag     1560

gaacagcaag tctgcatggc tgttgacata ggcagacatc ggtggaatca agtgaaaaag     1620

gaggaccaag aggcaacagg tcccaggctc agcagggagc tgctggatga gaaagggcct     1680

gaagtcttgc aggactcact ggatagatgt tattcaactc cttcaggttg ccttgaactg     1740

actgactcat gccagcccta cagaagtgcc ttttacatat tggagcaaca gcgtgttggc     1800

ttggctgttg acatggatga aattgaaaag taccaagaag tggaagaaga ccaagaccca     1860

tcatgcccca ggctcagcag ggagctgctg gatgagaaag agcctgaagt cttgcaggac     1920

tcactggata gatgttattc gactccttca ggttatcttg aactgcctga cttaggccag     1980

ccctacagca gtgctgttta ctcattggag gaacagtacc ttggcttggc tcttgacgtg     2040

gacagaatta aaaaggacca agaagaggaa gaagaccaag gcccaccatg ccccaggctc     2100

agcagggagc tgctggaggt agtagagcct gaagtcttgc aggactcact ggatagatgt     2160

tattcaactc cttccagttg tcttgaacag cctgactcct gccagccgta tggaagttcc     2220

ttttatgcat tggaggaaaa acatgttggc ttttctcttg acgtgggaga aattgaaaag     2280

aaggggaagg ggaagataag aaggggaaga agatcaaaga agaaaagaag aaggggaaga     2340

aaagaagggg aagaagatca aaacccacca tgccccaggc tcaacagcgt gctgatggaa     2400

gtggaagagc ctgaagtctt acaggactca ctggatagat gttattcgac tccatcaatg     2460

tactgtgaac tacgtgactc attccagcac tacagaagtg tgttttag                  2508


<210>  338
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Leu Arg Asn Glu Arg Gln Phe Lys Glu Glu Lys Leu Ala Glu Gln 
1               5                   10                  15      


Leu Lys Gln Ala Glu Glu Leu Arg Gln Tyr Lys Val Leu Val His Ser 
            20                  25                  30          


Gln Glu Arg Glu Leu Thr Gln Leu Lys Glu Lys Leu Arg Glu Gly Arg 
        35                  40                  45              


Asp Ala Ser Arg Ser Leu Asn Glu His Leu Gln Ala Leu Leu Thr Leu 
    50                  55                  60                  


Asp Glu Pro Asp Lys Ser Gln Gly Gln Asp Leu Gln Glu Gln Leu Ala 
65                  70                  75                  80  


Glu Gly Cys Arg Leu Ala Gln His Leu Val Gln Lys Leu Ser Pro Glu 
                85                  90                  95      


Asn Asp Glu Asp Glu Asp Glu Asp Val Gln Val Glu Glu Asp Glu Lys 
            100                 105                 110         


Val Gln Lys Ser Ser Ala Pro Arg Glu Val Gln Lys Ala Glu Val Ser 
        115                 120                 125             


Lys Val Pro Glu Asp Ser Leu Glu Glu Cys Ala Ile Thr Cys Ser Asn 
    130                 135                 140                 


Ser His Gly Pro Cys Asp Ser Asn Gln Pro His Lys Asn Ile Lys Ile 
145                 150                 155                 160 


Thr Phe Glu Glu Asp Glu Val Asn Ser Thr Leu Val Val Asp Arg Glu 
                165                 170                 175     


Ser Ser His Asp Glu Cys Gln Asp Ala Leu Asn Ile Leu Pro Val Pro 
            180                 185                 190         


Gly Pro Thr Ser Ser Ala Thr Asn Val Ser Met Val Val Ser Ala Gly 
        195                 200                 205             


Pro Leu Ser Ser Glu Lys Ala Glu Met Asn Ile Leu Glu Ile Asn Glu 
    210                 215                 220                 


Lys Leu His Pro Gln Leu Ala Glu Lys Lys Gln Gln Phe Arg Asn Leu 
225                 230                 235                 240 


Lys Glu Lys Cys Phe Leu Thr Gln Leu Ala Gly Phe Leu Ala Asn Gln 
                245                 250                 255     


Gln Asn Lys Tyr Lys Tyr Glu Glu Cys Lys Asp Leu Ile Lys Ser Met 
            260                 265                 270         


Leu Arg Asn Glu Arg Gln Phe Lys Glu Glu Lys Leu Ala Glu Gln Leu 
        275                 280                 285             


Lys Gln Ala Glu Glu Leu Arg Gln Tyr Lys Val Leu Val His Thr Gln 
    290                 295                 300                 


Glu Arg Glu Leu Thr Gln Leu Arg Glu Lys Leu Arg Glu Gly Arg Asp 
305                 310                 315                 320 


Ala Ser Arg Ser Leu Asn Glu His Leu Gln Ala Leu Leu Thr Leu Asp 
                325                 330                 335     


Glu Pro Asp Lys Ser Gln Gly Gln Asp Leu Gln Glu Gln Leu Ala Glu 
            340                 345                 350         


Gly Cys Arg Leu Ala Gln His Leu Val Gln Lys Leu Ser Pro Glu Asn 
        355                 360                 365             


Asp Asn Asp Asp Asp Glu Asp Val Gln Val Glu Val Ala Glu Lys Val 
    370                 375                 380                 


Gln Lys Ser Ser Ala Pro Arg Glu Met Gln Lys Ala Glu Glu Lys Glu 
385                 390                 395                 400 


Val Pro Glu Asp Ser Leu Glu Glu Cys Ala Ile Thr Tyr Ser Asn Ser 
                405                 410                 415     


His Gly Pro Tyr Asp Ser Asn Gln Pro His Arg Lys Thr Lys Ile Thr 
            420                 425                 430         


Phe Glu Glu Asp Lys Val Asp Ser Ala Leu Ile Gly Ser Ser Ser His 
        435                 440                 445             


Val Glu Trp Glu Asp Ala Val His Ile Ile Pro Glu Asn Glu Ser Asp 
    450                 455                 460                 


Asp Glu Glu Glu Glu Glu Lys Gly Pro Val Ser Pro Arg Asn Leu Gln 
465                 470                 475                 480 


Glu Ser Glu Glu Glu Glu Val Pro Gln Glu Ser Trp Asp Glu Gly Tyr 
                485                 490                 495     


Ser Thr Leu Ser Ile Pro Pro Glu Met Leu Ala Ser Tyr Lys Ser Tyr 
            500                 505                 510         


Ser Ser Thr Phe His Ser Leu Glu Glu Gln Gln Val Cys Met Ala Val 
        515                 520                 525             


Asp Ile Gly Arg His Arg Trp Asn Gln Val Lys Lys Glu Asp Gln Glu 
    530                 535                 540                 


Ala Thr Gly Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro 
545                 550                 555                 560 


Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly 
                565                 570                 575     


Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr 
            580                 585                 590         


Ile Leu Glu Gln Gln Arg Val Gly Leu Ala Val Asp Met Asp Glu Ile 
        595                 600                 605             


Glu Lys Tyr Gln Glu Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg 
    610                 615                 620                 


Leu Ser Arg Glu Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Asp 
625                 630                 635                 640 


Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro 
                645                 650                 655     


Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr Ser Leu Glu Glu Gln 
            660                 665                 670         


Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg Ile Lys Lys Asp Gln Glu 
        675                 680                 685             


Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu 
    690                 695                 700                 


Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys 
705                 710                 715                 720 


Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Gln Pro 
                725                 730                 735     


Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser 
            740                 745                 750         


Leu Asp Val Gly Glu Ile Glu Lys Lys Gly Lys Gly Lys Ile Arg Arg 
        755                 760                 765             


Gly Arg Arg Ser Lys Lys Lys Arg Arg Arg Gly Arg Lys Glu Gly Glu 
    770                 775                 780                 


Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Asn Ser Val Leu Met Glu 
785                 790                 795                 800 


Val Glu Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser 
                805                 810                 815     


Thr Pro Ser Met Tyr Cys Glu Leu Arg Asp Ser Phe Gln His Tyr Arg 
            820                 825                 830         


Ser Val Phe 
        835 


<210>  339
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  339
atgaggaggc tcgggccctt ccacccacgc gtccattggg cggcgccgcc atcactctct       60

tctgggctac accgccttct cttcctccgc ggaacccgga tcccctcctc caccaccctc      120

tccccgcccc gtcacgatag cctctcattg gacggaggca cggtcaatcc tcctcgagtt      180

agggagccga ctggacgcga ggcctttggg ccgtccccag cctcgtcgga ttggcttcct      240

gcgcgttggc gcaacggaag aggcggccgg ccgagggcgc gcctctgctc tggctggact      300

gccgcggagg aggcgagaag gaatccgacg ctggggggct tgctcgggcg gcagcgactg      360

ctgctgcgga tgggaggggg ccggctcggc gcgcccatgg agcgccacgg cagggcttcc      420

gccacctccg tctcgtcggc tggggagcag gcggccgggg accccgaagg gcggcggcag      480

gagccactgc ggcgccgggc gagcagcgcg tcggtgcccg cggtcggggc ctcggctgag      540

ggcacgaggc gggatcgact gggctcttac agcggcccca cctcggtctc ccgccagcgc      600

gtcgaaagcc tgaggaaaaa gcggccgctt tttccatggt ttggactgga tatcggtgga      660

actctggtca agctggtata ttttgaaccc aaagacatca ctgctgaaga agaagaggaa      720

gaagtggaaa gtcttaaaag cattcggaag tacctgacct ccaatgtggc ttatgggtct      780

acaggcattc gggacgtgca cctcgagctg aaggacctga ctctgtgtgg acgcaaaggc      840

aatctgcact ttatacgctt tcccactcat gacatgcctg cttttattca aatgggcaga      900

gataaaaact tctcgagtct ccacactgtc ttttgtgcca ctggaggtgg agcgtacaaa      960

tttgagcagg attttctcac aataggtgat cttcagcttt gcaaactgga tgaactagat     1020

tgcttgatca aaggaatttt atacattgac tcagtcggat tcaatggacg gtcacagtgc     1080

tattactttg aaaaccctgc tgattctgaa aagtgtcaga agttaccatt tgatttgaaa     1140

aatccgtatc ctctgcttct ggtgaacatt ggctcagggg ttagcatctt agcagtatat     1200

tccaaagata attacaaacg ggtcacaggt actagtcttg gaggaggaac tttttttggt     1260

ctctgctgtc ttcttactgg ctgtaccact tttgaagaag ctcttgaaat ggcatctcgt     1320

ggagatagca ccaaagtgga taaactagta cgagatattt atggagggga ctatgagagg     1380

tttggactgc caggctgggc tgtggcttca agctttggaa acatgatgag caaggagaag     1440

cgagaggctg tcagtaaaga ggacctggcc agagcgactt tgatcaccat caccaacaac     1500

attggctcaa tagcaagaat gtgtgccctt aatgaaaaca ttaaccaggt ggtatttgtt     1560

ggaaatttct tgagaattaa tacgatcgcc atgcggcttt tggcatatgc tttggattat     1620

tggtccaagg ggcagttgaa agcacttttt tcggaacacg agggttattt tggagctgtt     1680

ggagcactcc ttgagctgtt gaagatcccg tga                                  1713


<210>  340
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Arg Arg Leu Gly Pro Phe His Pro Arg Val His Trp Ala Ala Pro 
1               5                   10                  15      


Pro Ser Leu Ser Ser Gly Leu His Arg Leu Leu Phe Leu Arg Gly Thr 
            20                  25                  30          


Arg Ile Pro Ser Ser Thr Thr Leu Ser Pro Pro Arg His Asp Ser Leu 
        35                  40                  45              


Ser Leu Asp Gly Gly Thr Val Asn Pro Pro Arg Val Arg Glu Pro Thr 
    50                  55                  60                  


Gly Arg Glu Ala Phe Gly Pro Ser Pro Ala Ser Ser Asp Trp Leu Pro 
65                  70                  75                  80  


Ala Arg Trp Arg Asn Gly Arg Gly Gly Arg Pro Arg Ala Arg Leu Cys 
                85                  90                  95      


Ser Gly Trp Thr Ala Ala Glu Glu Ala Arg Arg Asn Pro Thr Leu Gly 
            100                 105                 110         


Gly Leu Leu Gly Arg Gln Arg Leu Leu Leu Arg Met Gly Gly Gly Arg 
        115                 120                 125             


Leu Gly Ala Pro Met Glu Arg His Gly Arg Ala Ser Ala Thr Ser Val 
    130                 135                 140                 


Ser Ser Ala Gly Glu Gln Ala Ala Gly Asp Pro Glu Gly Arg Arg Gln 
145                 150                 155                 160 


Glu Pro Leu Arg Arg Arg Ala Ser Ser Ala Ser Val Pro Ala Val Gly 
                165                 170                 175     


Ala Ser Ala Glu Gly Thr Arg Arg Asp Arg Leu Gly Ser Tyr Ser Gly 
            180                 185                 190         


Pro Thr Ser Val Ser Arg Gln Arg Val Glu Ser Leu Arg Lys Lys Arg 
        195                 200                 205             


Pro Leu Phe Pro Trp Phe Gly Leu Asp Ile Gly Gly Thr Leu Val Lys 
    210                 215                 220                 


Leu Val Tyr Phe Glu Pro Lys Asp Ile Thr Ala Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Glu Val Glu Ser Leu Lys Ser Ile Arg Lys Tyr Leu Thr Ser Asn Val 
                245                 250                 255     


Ala Tyr Gly Ser Thr Gly Ile Arg Asp Val His Leu Glu Leu Lys Asp 
            260                 265                 270         


Leu Thr Leu Cys Gly Arg Lys Gly Asn Leu His Phe Ile Arg Phe Pro 
        275                 280                 285             


Thr His Asp Met Pro Ala Phe Ile Gln Met Gly Arg Asp Lys Asn Phe 
    290                 295                 300                 


Ser Ser Leu His Thr Val Phe Cys Ala Thr Gly Gly Gly Ala Tyr Lys 
305                 310                 315                 320 


Phe Glu Gln Asp Phe Leu Thr Ile Gly Asp Leu Gln Leu Cys Lys Leu 
                325                 330                 335     


Asp Glu Leu Asp Cys Leu Ile Lys Gly Ile Leu Tyr Ile Asp Ser Val 
            340                 345                 350         


Gly Phe Asn Gly Arg Ser Gln Cys Tyr Tyr Phe Glu Asn Pro Ala Asp 
        355                 360                 365             


Ser Glu Lys Cys Gln Lys Leu Pro Phe Asp Leu Lys Asn Pro Tyr Pro 
    370                 375                 380                 


Leu Leu Leu Val Asn Ile Gly Ser Gly Val Ser Ile Leu Ala Val Tyr 
385                 390                 395                 400 


Ser Lys Asp Asn Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly Gly Gly 
                405                 410                 415     


Thr Phe Phe Gly Leu Cys Cys Leu Leu Thr Gly Cys Thr Thr Phe Glu 
            420                 425                 430         


Glu Ala Leu Glu Met Ala Ser Arg Gly Asp Ser Thr Lys Val Asp Lys 
        435                 440                 445             


Leu Val Arg Asp Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu Pro 
    450                 455                 460                 


Gly Trp Ala Val Ala Ser Ser Phe Gly Asn Met Met Ser Lys Glu Lys 
465                 470                 475                 480 


Arg Glu Ala Val Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu Ile Thr 
                485                 490                 495     


Ile Thr Asn Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu Asn Glu 
            500                 505                 510         


Asn Ile Asn Gln Val Val Phe Val Gly Asn Phe Leu Arg Ile Asn Thr 
        515                 520                 525             


Ile Ala Met Arg Leu Leu Ala Tyr Ala Leu Asp Tyr Trp Ser Lys Gly 
    530                 535                 540                 


Gln Leu Lys Ala Leu Phe Ser Glu His Glu Gly Tyr Phe Gly Ala Val 
545                 550                 555                 560 


Gly Ala Leu Leu Glu Leu Leu Lys Ile Pro 
                565                 570 


<210>  341
<211>  5379
<212>  DNA
<213>  Homo sapiens

<400>  341
atgtcctgtg tgcattataa attttcctct aaactcaact atgataccgt cacctttgat       60

gggctccaca tctccctctg cgacttaaag aagcagatta tggggagaga gaagctgaaa      120

gctgccgact gcgacctgca gatcaccaat gcgcagacga aagaagaata tactgatgat      180

aatgctctga ttcctaagaa ttcttctgta attgttagaa gaattcctat tggaggtgtt      240

aaatctacaa gcaagacata tgttataagt cgaactgaac cagcgatggc aactacaaaa      300

gcaattgatg actcttccgc gtctatttct ctggcccagc ttacaaagac tgccaatctg      360

gctgaagcca atgcttctga agaagataaa attaaagcaa tgatgtcgca atctggccat      420

gaatacgacc caatcaatta catgaagaaa cctctaggtc caccacctcc atcttacacg      480

tgtttccgtt gtggtaaacc tggacattat attaagaatt gcccaacaaa tggggataaa      540

aactttgaat ctggtcctag gattaaaaag agcactggaa ttcccagaag tttcatgatg      600

gaagtgaaag atcctaatat gaaaggtgca atgcttacca acactggaaa atatgcaata      660

ccaactatag atgcagaagc atatgcaatt gggaagaaag agaaacctcc cttcttacca      720

gaggagccat cttcttcctc agaagaagat gatcctatcc cagatgaatt gttgtgtctc      780

atctgcaagg atattatgac tgatgctgtt gtgattccct gctgtggaaa cagttactgt      840

gatgaatgta taagaacagc actcctggaa tcagatgagc acacatgtcc gacgtgtcat      900

caaaatgatg tttctcctga tgctttaatt gccaataaat ttttacgaca ggctgtaaat      960

aacttcaaaa atgaaactgg ctatacaaaa agactacgaa aacagttacc tcctccacca     1020

cccccaatac cacctccgag accactgatt cagaggaacc tacaacctct gatgagatct     1080

ccgatatcaa gacaacaaga tcctcttatg attccagtga catcttcatc aactcaccca     1140

gctccgtcta tatcttcatt aacttctaat cagtcttcct tggcccctcc tgtgtctgga     1200

aatccgtctt ctgctccagc tcctgtacct gatataactg caacagtatc catatcagtt     1260

cattcagaaa aatcagatgg accttttcgg gattctgata ataaaatatt gccagctgca     1320

gctcttgcat cagagcactc aaagggaacc tcctcaattg caattaccgc tcttatggaa     1380

gagaagggtt accaggtgcc tgttcttgga accccatctt tgcttggaca gtcattattg     1440

catggacagt tgatccccac aactggtcca gtaagaataa atactgctcg tccaggtggt     1500

ggtcgaccag gctgggaaca ttccaacaaa cttggctatc tggtttctcc accacaacaa     1560

attagaagag gggagaggag ctgctacaga agtataaacc gtgggcgaca ccacagcgaa     1620

agatcacaga ggactcaagg cccgtcacta ccagcaactc cagtctttgt acctgttcca     1680

ccacctcctt tgtatccgcc tcctccccat acacttcctc tccctccggg tgttcctcct     1740

ccacagtttt ctcctcagtt tcctcctggc cagccaccac ccgctgggta tagtgtccct     1800

cctccagggt ttcctccagc tcctgccaat ttatcaacac cttgggtatc atcaggagtg     1860

cagacagctc attcaaatac catcccaaca acacaagcac cacctttgtc cagggaagaa     1920

ttctatagag agcagcgacg actaaaagaa gaggaaaaga aaaagtccaa gctagatgag     1980

tttacaaatg attttgctaa ggaattgatg gaatacaaaa agattcaaaa ggagcgtagg     2040

cgctcatttt ccaggtctaa atctccctat agtggttctt cgtattcaag aagttcatat     2100

acttattcta aatcaagatc tggttcaaca cgttcacgct cttattctcg atcattcagc     2160

cgctcacatt ctcgttccta ttcacggtca cctccatacc ccagaagagg cagaggcaag     2220

agccgcaatt accgttcacg gtctagatct catggatatc atcgatctag gtcaaggtca     2280

cccccttaca gacgctatca ttcacgatca agatctcctc aagcgtttag gggacagtct     2340

cctaataaac gtaatgtacc tcaaggggaa acagaacgtg aatattttaa tagatacaga     2400

gaagttccac caccatatga catgaaagca tattatggga gaagtgttga ctttagagac     2460

ccatttgaaa aagaacgcta ccgagaatgg gagagaaaat atagagagtg gtatgaaaaa     2520

tattataaag gttatgctgc tggagcacag cctagaccct cagcaaatag agagaacttt     2580

tctccagaga gatttttgcc acttaacatc aggaattctc ccttcacaag aggccgcaga     2640

gaagactatg ttggtgggca aagtcataga agtcgaaaca taggtagcaa ctatccagaa     2700

aagctttcag caagagatgg tcacaatcag aaggataata caaagtcaaa agagaaggag     2760

agtgaaaacg ctccaggaga tggtaaagga aataagcata agaaacacag aaaaagaaga     2820

aaaggggagg aaagtgaggg ttttctgaac ccagagttat tagagacttc taggaaatca     2880

agagaaccta caggtgttga agaaaataaa acagactcat tgtttgttct cccaagtaga     2940

gatgatgcca cacctgttag agatgaacca atggatgcag aatcaatcac ttttaaatca     3000

gtgtctgaaa aagacaagag agaaagggat aaaccaaaag caaagggtga taaaaccaaa     3060

cggaagaatg atggatctgc tgtgtccaaa aaagaaaata ttgtaaaacc tgctaaagga     3120

ccccaagaaa aagtagatgg agaacgtgag agatctcctc gatctgaacc tccaattaaa     3180

aaagccaaag aggagactcc gaagactgac aatactaaat catcatcttc ctctcagaag     3240

gatgaaaaaa tcactggaac ccccagaaaa gctcactcta aatcagcaaa agaacaccaa     3300

gaaacaaaac cagtcaaaga ggaaaaagtg aagaaggact attccaaaga tgtcaaatca     3360

gaaaagctaa caactaagga agaaaaggcc aagaagccta atgagaaaaa caaaccactt     3420

gataataagg gagaaaaaag aaaaagaaaa actgaagaaa aaggcgtaga taaagatttt     3480

gagtcttctt caatgaaaat ctcgaaacta gaagtgactg aaatagtgaa accatcacca     3540

aagcgcaaaa tggaacctga tactgaaaaa atggatagga cccctgaaaa ggacaaaatt     3600

tctttaagtg cgccagccaa aaaaatcaaa ctcaacagag aaactgggaa gaaaattgga     3660

agtacagaaa atatatcaaa cacaaaagaa ccctctgaaa aattggagtc aacatctagc     3720

aaagttaaac aagaaaaagt caaaggaaag gtcagacgaa aagtgactgg aactgaagga     3780

tccagctcaa ctctggtgga ttacaccagt acgagctcaa ctggaggcag tcctgtgcgg     3840

aaatctgaag aaaaaacaga tacaaagcga actgtgatta aaacgatgga agaatataat     3900

aatgacaata ccgcgccagc tgaagatgtt atcattatga ttcaggttcc tcaatccaaa     3960

tgggataaag atgactttga atctgaagaa gaagatgtta aatccacaca gcctatatca     4020

agtgtaggaa aacctgctag tgttataaaa aatgttagta caaagccatc aaatatagtc     4080

aagtatcctg agaaagaaag tgagccatcc gagaaaattc agaaattcac caaggacgtg     4140

agccatgaaa tcatacaaca tgaggttaaa agttcaaaaa actctgcatc tagtgaaaaa     4200

gggaaaacca aagatcgaga ttattcagtg ttggaaaagg agaaccctga aaagaggaag     4260

aacagcactc agccagagaa agagagtaat ttggaccgtc tgaatgaaca aggaaatttt     4320

aaaagtctgt ctcaatcttc caaagaggct agaacgtcag ataaacatga ttccactcgt     4380

gcttcctcaa ataaagactt cactcccaat agagacaaaa aaactgacta tgacaccaga     4440

gagtattcaa gttccaaacg tagagatgaa aagaatgaat taacaagacg aaaagactct     4500

ccttctcgga ataaagattc tgcatctgga cagaaaaata aaccaaggga agagagagat     4560

ttgcctaaaa aaggaacagg agattccaaa aaaagtaatt ctagtccctc aagagacaga     4620

aaacctcatg atcacaaagc cacttatgat actaaacggc caaatgaaga gacaaaatct     4680

gtagataaaa atccttgtaa ggatcgtgag aagcatgtat tagaagcaag gaacaataaa     4740

gagtcaagtg gcaataaact actttatata cttaacccac cagagacaca ggttgaaaaa     4800

gagcaaatta ctgggcaaat tgacaagagt actgtcaagc ctaaacccca gttaagtcat     4860

tcctctagac tttcctctga cttaactaga gaaactgatg aagctgcttt tgaaccagac     4920

tataatgaaa gtgacagtga aagtaatgtt tctgtaaaag aagaggaatc ttcaggaaac     4980

atttctaagg acctgaaaga taaaatagtg gagaaagcaa aagagagcct ggacacagca     5040

gcagttgtcc aggtgggcat aagcaggaat cagagccaca gcagccccag cgtcagcccc     5100

agcagaagcc acagtccttc tggaagccag acccgaagcc acagtagcag tgccagctca     5160

gcagaaagtc aggacagcaa gaagaagaag aaaaagaagg aaaagaaaaa acacaagaaa     5220

cataaaaagc ataagaagca taagaaacat gcaggcactg aagtggaatt ggaaaaaagc     5280

caaaaacaca aacacaagaa aaagaagtca aagaagaaca aagataaaga gaaggagaag     5340

gagaaagatg accaaaaagt gaaatctgtc actgtgtaa                            5379


<210>  342
<211>  1792
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ser Cys Val His Tyr Lys Phe Ser Ser Lys Leu Asn Tyr Asp Thr 
1               5                   10                  15      


Val Thr Phe Asp Gly Leu His Ile Ser Leu Cys Asp Leu Lys Lys Gln 
            20                  25                  30          


Ile Met Gly Arg Glu Lys Leu Lys Ala Ala Asp Cys Asp Leu Gln Ile 
        35                  40                  45              


Thr Asn Ala Gln Thr Lys Glu Glu Tyr Thr Asp Asp Asn Ala Leu Ile 
    50                  55                  60                  


Pro Lys Asn Ser Ser Val Ile Val Arg Arg Ile Pro Ile Gly Gly Val 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Thr Tyr Val Ile Ser Arg Thr Glu Pro Ala Met 
                85                  90                  95      


Ala Thr Thr Lys Ala Ile Asp Asp Ser Ser Ala Ser Ile Ser Leu Ala 
            100                 105                 110         


Gln Leu Thr Lys Thr Ala Asn Leu Ala Glu Ala Asn Ala Ser Glu Glu 
        115                 120                 125             


Asp Lys Ile Lys Ala Met Met Ser Gln Ser Gly His Glu Tyr Asp Pro 
    130                 135                 140                 


Ile Asn Tyr Met Lys Lys Pro Leu Gly Pro Pro Pro Pro Ser Tyr Thr 
145                 150                 155                 160 


Cys Phe Arg Cys Gly Lys Pro Gly His Tyr Ile Lys Asn Cys Pro Thr 
                165                 170                 175     


Asn Gly Asp Lys Asn Phe Glu Ser Gly Pro Arg Ile Lys Lys Ser Thr 
            180                 185                 190         


Gly Ile Pro Arg Ser Phe Met Met Glu Val Lys Asp Pro Asn Met Lys 
        195                 200                 205             


Gly Ala Met Leu Thr Asn Thr Gly Lys Tyr Ala Ile Pro Thr Ile Asp 
    210                 215                 220                 


Ala Glu Ala Tyr Ala Ile Gly Lys Lys Glu Lys Pro Pro Phe Leu Pro 
225                 230                 235                 240 


Glu Glu Pro Ser Ser Ser Ser Glu Glu Asp Asp Pro Ile Pro Asp Glu 
                245                 250                 255     


Leu Leu Cys Leu Ile Cys Lys Asp Ile Met Thr Asp Ala Val Val Ile 
            260                 265                 270         


Pro Cys Cys Gly Asn Ser Tyr Cys Asp Glu Cys Ile Arg Thr Ala Leu 
        275                 280                 285             


Leu Glu Ser Asp Glu His Thr Cys Pro Thr Cys His Gln Asn Asp Val 
    290                 295                 300                 


Ser Pro Asp Ala Leu Ile Ala Asn Lys Phe Leu Arg Gln Ala Val Asn 
305                 310                 315                 320 


Asn Phe Lys Asn Glu Thr Gly Tyr Thr Lys Arg Leu Arg Lys Gln Leu 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Ile Pro Pro Pro Arg Pro Leu Ile Gln Arg 
            340                 345                 350         


Asn Leu Gln Pro Leu Met Arg Ser Pro Ile Ser Arg Gln Gln Asp Pro 
        355                 360                 365             


Leu Met Ile Pro Val Thr Ser Ser Ser Thr His Pro Ala Pro Ser Ile 
    370                 375                 380                 


Ser Ser Leu Thr Ser Asn Gln Ser Ser Leu Ala Pro Pro Val Ser Gly 
385                 390                 395                 400 


Asn Pro Ser Ser Ala Pro Ala Pro Val Pro Asp Ile Thr Ala Thr Val 
                405                 410                 415     


Ser Ile Ser Val His Ser Glu Lys Ser Asp Gly Pro Phe Arg Asp Ser 
            420                 425                 430         


Asp Asn Lys Ile Leu Pro Ala Ala Ala Leu Ala Ser Glu His Ser Lys 
        435                 440                 445             


Gly Thr Ser Ser Ile Ala Ile Thr Ala Leu Met Glu Glu Lys Gly Tyr 
    450                 455                 460                 


Gln Val Pro Val Leu Gly Thr Pro Ser Leu Leu Gly Gln Ser Leu Leu 
465                 470                 475                 480 


His Gly Gln Leu Ile Pro Thr Thr Gly Pro Val Arg Ile Asn Thr Ala 
                485                 490                 495     


Arg Pro Gly Gly Gly Arg Pro Gly Trp Glu His Ser Asn Lys Leu Gly 
            500                 505                 510         


Tyr Leu Val Ser Pro Pro Gln Gln Ile Arg Arg Gly Glu Arg Ser Cys 
        515                 520                 525             


Tyr Arg Ser Ile Asn Arg Gly Arg His His Ser Glu Arg Ser Gln Arg 
    530                 535                 540                 


Thr Gln Gly Pro Ser Leu Pro Ala Thr Pro Val Phe Val Pro Val Pro 
545                 550                 555                 560 


Pro Pro Pro Leu Tyr Pro Pro Pro Pro His Thr Leu Pro Leu Pro Pro 
                565                 570                 575     


Gly Val Pro Pro Pro Gln Phe Ser Pro Gln Phe Pro Pro Gly Gln Pro 
            580                 585                 590         


Pro Pro Ala Gly Tyr Ser Val Pro Pro Pro Gly Phe Pro Pro Ala Pro 
        595                 600                 605             


Ala Asn Leu Ser Thr Pro Trp Val Ser Ser Gly Val Gln Thr Ala His 
    610                 615                 620                 


Ser Asn Thr Ile Pro Thr Thr Gln Ala Pro Pro Leu Ser Arg Glu Glu 
625                 630                 635                 640 


Phe Tyr Arg Glu Gln Arg Arg Leu Lys Glu Glu Glu Lys Lys Lys Ser 
                645                 650                 655     


Lys Leu Asp Glu Phe Thr Asn Asp Phe Ala Lys Glu Leu Met Glu Tyr 
            660                 665                 670         


Lys Lys Ile Gln Lys Glu Arg Arg Arg Ser Phe Ser Arg Ser Lys Ser 
        675                 680                 685             


Pro Tyr Ser Gly Ser Ser Tyr Ser Arg Ser Ser Tyr Thr Tyr Ser Lys 
    690                 695                 700                 


Ser Arg Ser Gly Ser Thr Arg Ser Arg Ser Tyr Ser Arg Ser Phe Ser 
705                 710                 715                 720 


Arg Ser His Ser Arg Ser Tyr Ser Arg Ser Pro Pro Tyr Pro Arg Arg 
                725                 730                 735     


Gly Arg Gly Lys Ser Arg Asn Tyr Arg Ser Arg Ser Arg Ser His Gly 
            740                 745                 750         


Tyr His Arg Ser Arg Ser Arg Ser Pro Pro Tyr Arg Arg Tyr His Ser 
        755                 760                 765             


Arg Ser Arg Ser Pro Gln Ala Phe Arg Gly Gln Ser Pro Asn Lys Arg 
    770                 775                 780                 


Asn Val Pro Gln Gly Glu Thr Glu Arg Glu Tyr Phe Asn Arg Tyr Arg 
785                 790                 795                 800 


Glu Val Pro Pro Pro Tyr Asp Met Lys Ala Tyr Tyr Gly Arg Ser Val 
                805                 810                 815     


Asp Phe Arg Asp Pro Phe Glu Lys Glu Arg Tyr Arg Glu Trp Glu Arg 
            820                 825                 830         


Lys Tyr Arg Glu Trp Tyr Glu Lys Tyr Tyr Lys Gly Tyr Ala Ala Gly 
        835                 840                 845             


Ala Gln Pro Arg Pro Ser Ala Asn Arg Glu Asn Phe Ser Pro Glu Arg 
    850                 855                 860                 


Phe Leu Pro Leu Asn Ile Arg Asn Ser Pro Phe Thr Arg Gly Arg Arg 
865                 870                 875                 880 


Glu Asp Tyr Val Gly Gly Gln Ser His Arg Ser Arg Asn Ile Gly Ser 
                885                 890                 895     


Asn Tyr Pro Glu Lys Leu Ser Ala Arg Asp Gly His Asn Gln Lys Asp 
            900                 905                 910         


Asn Thr Lys Ser Lys Glu Lys Glu Ser Glu Asn Ala Pro Gly Asp Gly 
        915                 920                 925             


Lys Gly Asn Lys His Lys Lys His Arg Lys Arg Arg Lys Gly Glu Glu 
    930                 935                 940                 


Ser Glu Gly Phe Leu Asn Pro Glu Leu Leu Glu Thr Ser Arg Lys Ser 
945                 950                 955                 960 


Arg Glu Pro Thr Gly Val Glu Glu Asn Lys Thr Asp Ser Leu Phe Val 
                965                 970                 975     


Leu Pro Ser Arg Asp Asp Ala Thr Pro Val Arg Asp Glu Pro Met Asp 
            980                 985                 990         


Ala Glu Ser Ile Thr Phe Lys Ser  Val Ser Glu Lys Asp  Lys Arg Glu 
        995                 1000                 1005             


Arg Asp  Lys Pro Lys Ala Lys  Gly Asp Lys Thr Lys  Arg Lys Asn 
    1010                 1015                 1020             


Asp Gly  Ser Ala Val Ser Lys  Lys Glu Asn Ile Val  Lys Pro Ala 
    1025                 1030                 1035             


Lys Gly  Pro Gln Glu Lys Val  Asp Gly Glu Arg Glu  Arg Ser Pro 
    1040                 1045                 1050             


Arg Ser  Glu Pro Pro Ile Lys  Lys Ala Lys Glu Glu  Thr Pro Lys 
    1055                 1060                 1065             


Thr Asp  Asn Thr Lys Ser Ser  Ser Ser Ser Gln Lys  Asp Glu Lys 
    1070                 1075                 1080             


Ile Thr  Gly Thr Pro Arg Lys  Ala His Ser Lys Ser  Ala Lys Glu 
    1085                 1090                 1095             


His Gln  Glu Thr Lys Pro Val  Lys Glu Glu Lys Val  Lys Lys Asp 
    1100                 1105                 1110             


Tyr Ser  Lys Asp Val Lys Ser  Glu Lys Leu Thr Thr  Lys Glu Glu 
    1115                 1120                 1125             


Lys Ala  Lys Lys Pro Asn Glu  Lys Asn Lys Pro Leu  Asp Asn Lys 
    1130                 1135                 1140             


Gly Glu  Lys Arg Lys Arg Lys  Thr Glu Glu Lys Gly  Val Asp Lys 
    1145                 1150                 1155             


Asp Phe  Glu Ser Ser Ser Met  Lys Ile Ser Lys Leu  Glu Val Thr 
    1160                 1165                 1170             


Glu Ile  Val Lys Pro Ser Pro  Lys Arg Lys Met Glu  Pro Asp Thr 
    1175                 1180                 1185             


Glu Lys  Met Asp Arg Thr Pro  Glu Lys Asp Lys Ile  Ser Leu Ser 
    1190                 1195                 1200             


Ala Pro  Ala Lys Lys Ile Lys  Leu Asn Arg Glu Thr  Gly Lys Lys 
    1205                 1210                 1215             


Ile Gly  Ser Thr Glu Asn Ile  Ser Asn Thr Lys Glu  Pro Ser Glu 
    1220                 1225                 1230             


Lys Leu  Glu Ser Thr Ser Ser  Lys Val Lys Gln Glu  Lys Val Lys 
    1235                 1240                 1245             


Gly Lys  Val Arg Arg Lys Val  Thr Gly Thr Glu Gly  Ser Ser Ser 
    1250                 1255                 1260             


Thr Leu  Val Asp Tyr Thr Ser  Thr Ser Ser Thr Gly  Gly Ser Pro 
    1265                 1270                 1275             


Val Arg  Lys Ser Glu Glu Lys  Thr Asp Thr Lys Arg  Thr Val Ile 
    1280                 1285                 1290             


Lys Thr  Met Glu Glu Tyr Asn  Asn Asp Asn Thr Ala  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Ile Ile Met Ile Gln  Val Pro Gln Ser Lys  Trp Asp Lys 
    1310                 1315                 1320             


Asp Asp  Phe Glu Ser Glu Glu  Glu Asp Val Lys Ser  Thr Gln Pro 
    1325                 1330                 1335             


Ile Ser  Ser Val Gly Lys Pro  Ala Ser Val Ile Lys  Asn Val Ser 
    1340                 1345                 1350             


Thr Lys  Pro Ser Asn Ile Val  Lys Tyr Pro Glu Lys  Glu Ser Glu 
    1355                 1360                 1365             


Pro Ser  Glu Lys Ile Gln Lys  Phe Thr Lys Asp Val  Ser His Glu 
    1370                 1375                 1380             


Ile Ile  Gln His Glu Val Lys  Ser Ser Lys Asn Ser  Ala Ser Ser 
    1385                 1390                 1395             


Glu Lys  Gly Lys Thr Lys Asp  Arg Asp Tyr Ser Val  Leu Glu Lys 
    1400                 1405                 1410             


Glu Asn  Pro Glu Lys Arg Lys  Asn Ser Thr Gln Pro  Glu Lys Glu 
    1415                 1420                 1425             


Ser Asn  Leu Asp Arg Leu Asn  Glu Gln Gly Asn Phe  Lys Ser Leu 
    1430                 1435                 1440             


Ser Gln  Ser Ser Lys Glu Ala  Arg Thr Ser Asp Lys  His Asp Ser 
    1445                 1450                 1455             


Thr Arg  Ala Ser Ser Asn Lys  Asp Phe Thr Pro Asn  Arg Asp Lys 
    1460                 1465                 1470             


Lys Thr  Asp Tyr Asp Thr Arg  Glu Tyr Ser Ser Ser  Lys Arg Arg 
    1475                 1480                 1485             


Asp Glu  Lys Asn Glu Leu Thr  Arg Arg Lys Asp Ser  Pro Ser Arg 
    1490                 1495                 1500             


Asn Lys  Asp Ser Ala Ser Gly  Gln Lys Asn Lys Pro  Arg Glu Glu 
    1505                 1510                 1515             


Arg Asp  Leu Pro Lys Lys Gly  Thr Gly Asp Ser Lys  Lys Ser Asn 
    1520                 1525                 1530             


Ser Ser  Pro Ser Arg Asp Arg  Lys Pro His Asp His  Lys Ala Thr 
    1535                 1540                 1545             


Tyr Asp  Thr Lys Arg Pro Asn  Glu Glu Thr Lys Ser  Val Asp Lys 
    1550                 1555                 1560             


Asn Pro  Cys Lys Asp Arg Glu  Lys His Val Leu Glu  Ala Arg Asn 
    1565                 1570                 1575             


Asn Lys  Glu Ser Ser Gly Asn  Lys Leu Leu Tyr Ile  Leu Asn Pro 
    1580                 1585                 1590             


Pro Glu  Thr Gln Val Glu Lys  Glu Gln Ile Thr Gly  Gln Ile Asp 
    1595                 1600                 1605             


Lys Ser  Thr Val Lys Pro Lys  Pro Gln Leu Ser His  Ser Ser Arg 
    1610                 1615                 1620             


Leu Ser  Ser Asp Leu Thr Arg  Glu Thr Asp Glu Ala  Ala Phe Glu 
    1625                 1630                 1635             


Pro Asp  Tyr Asn Glu Ser Asp  Ser Glu Ser Asn Val  Ser Val Lys 
    1640                 1645                 1650             


Glu Glu  Glu Ser Ser Gly Asn  Ile Ser Lys Asp Leu  Lys Asp Lys 
    1655                 1660                 1665             


Ile Val  Glu Lys Ala Lys Glu  Ser Leu Asp Thr Ala  Ala Val Val 
    1670                 1675                 1680             


Gln Val  Gly Ile Ser Arg Asn  Gln Ser His Ser Ser  Pro Ser Val 
    1685                 1690                 1695             


Ser Pro  Ser Arg Ser His Ser  Pro Ser Gly Ser Gln  Thr Arg Ser 
    1700                 1705                 1710             


His Ser  Ser Ser Ala Ser Ser  Ala Glu Ser Gln Asp  Ser Lys Lys 
    1715                 1720                 1725             


Lys Lys  Lys Lys Lys Glu Lys  Lys Lys His Lys Lys  His Lys Lys 
    1730                 1735                 1740             


His Lys  Lys His Lys Lys His  Ala Gly Thr Glu Val  Glu Leu Glu 
    1745                 1750                 1755             


Lys Ser  Gln Lys His Lys His  Lys Lys Lys Lys Ser  Lys Lys Asn 
    1760                 1765                 1770             


Lys Asp  Lys Glu Lys Glu Lys  Glu Lys Asp Asp Gln  Lys Val Lys 
    1775                 1780                 1785             


Ser Val  Thr Val 
    1790         


<210>  343
<211>  2086
<212>  DNA
<213>  Homo sapiens

<400>  343
ccgcacactg aagagtacgt cttcgggtct acccctaatc acataatggc tgtgtttaat       60

cagaagtctg tctcggatat gattaaagag tttcgaaaaa attggcgtgc tctttgtaac      120

tctgagagaa ccactctatg tggtgcagac tccatgctct tggcattgca gctttctatg      180

gcggagaaca acaaacagca cagtggagaa tttacagtct ctctcagtga tgttttattg      240

acatggaaat acttgctcca tgagaaattg aacttaccag ttgaaaacat ggacgtgact      300

gaccattatg aggacgttag gaagatttat gatgatttct tgaagaacag taatatgtta      360

gatctgattg atgtttatca aaaatgtagg gctttgactt ctaattgtga aaattataac      420

acagtatctc ctagtcaact actggatttt ctgtctggca aacagtatgc agtaggtgat      480

gaaactgatc tttctatacc aacatcacca acaagtaaat acaaccgtga taatgaaaag      540

gtgcagctgc tagcaaggaa aattatcttt tcatatttaa atctgctagt gaattcaaag      600

aatgacctgg ctgtggctta tattctcaat attcctgata gaggactagg aagagaagcc      660

ttcactgatt tgaaacatgc tgctcgagag aaacaaatgt ctatcttttt ggtggccacg      720

tcttttatta gaacaataga gcttggaggg aaaggatatg caccaccacc atcagatcct      780

ttaaggacac atgtaaaggg attgtctaat tttattaatt tcattgacaa attagatgag      840

attcttggag aaataccaaa cccaagcatt gcagggggtc aaatactgtc agtgataaag      900

atgcaactga ttaaaggcca aaacagcagg gatccttttt gcaaagcaat agaggaagtt      960

gctcaggatt tggatttgag gattaaaaat attatcaatt ctcaagaagg tgttgtagct     1020

cttagcacca ctgacatcag tcctgctcgg ccaaaatctc atgccataaa ccatggtact     1080

gcatactgtg gcagagatac tgtgaaagcc ttattagttc ttttggacga agaagcagct     1140

aatgctccta ccaaaaacaa agcagagctt ttatatgatg aggaaaacac aatccatcat     1200

catggaacgt ctattcttac actttttagg tctcccacac aggtgaataa ttcgataaaa     1260

cccctaagag aacgcatctg tgtgtcaatg caagagaaaa aaattaagat gaagcaaact     1320

ttaattagat cccaatttgc ttgtacttat aaagatgact acatgataag caaggataat     1380

tggaataatg ttaatttagc atcaaagcct ttgtgtgttc tttacatgga aaatgacctt     1440

tctgagggtg taaatccatc tgttggaaga tcaacaattg gaacgagttt tggaaatgtt     1500

catctggaca gaagtaaaaa tgaaaaagta tcaagaaaat caaccagtca gacaggaaat     1560

aaaagctcaa aaaggaaaca ggtggatttg gatggtgaaa atattctctg tgataataga     1620

aatgaaccac ctcaacataa aaatgctaaa atacctaaga aatcaaatga ttcacagaat     1680

agattgtacg gcaaactagc taaagtagca aaaagtaata aatgtactgc caaggacaag     1740

ttgatttctg gccaggcaaa gttaactcag ttttttagac tataaatttg tgtcttatat     1800

gctttaggtt tatgtatcta taaaccattc accaaagaca tgcttaattt ttaagagatc     1860

aaggtgtaaa ttatgatgat ttattatttt ggtctacagt gtatgtaagg ttagtatgtt     1920

aagcattgtt taaaaatact agtaagtcat aattatgcag aattttcaca aagtttaatg     1980

cacagagaaa gcatatcatt tcagttactg atacatctta acactacttt cttttaaaac     2040

agacatttaa catacacaag ttatagtagc agtatgggct tctcct                    2086


<210>  344
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ala Val Phe Asn Gln Lys Ser Val Ser Asp Met Ile Lys Glu Phe 
1               5                   10                  15      


Arg Lys Asn Trp Arg Ala Leu Cys Asn Ser Glu Arg Thr Thr Leu Cys 
            20                  25                  30          


Gly Ala Asp Ser Met Leu Leu Ala Leu Gln Leu Ser Met Ala Glu Asn 
        35                  40                  45              


Asn Lys Gln His Ser Gly Glu Phe Thr Val Ser Leu Ser Asp Val Leu 
    50                  55                  60                  


Leu Thr Trp Lys Tyr Leu Leu His Glu Lys Leu Asn Leu Pro Val Glu 
65                  70                  75                  80  


Asn Met Asp Val Thr Asp His Tyr Glu Asp Val Arg Lys Ile Tyr Asp 
                85                  90                  95      


Asp Phe Leu Lys Asn Ser Asn Met Leu Asp Leu Ile Asp Val Tyr Gln 
            100                 105                 110         


Lys Cys Arg Ala Leu Thr Ser Asn Cys Glu Asn Tyr Asn Thr Val Ser 
        115                 120                 125             


Pro Ser Gln Leu Leu Asp Phe Leu Ser Gly Lys Gln Tyr Ala Val Gly 
    130                 135                 140                 


Asp Glu Thr Asp Leu Ser Ile Pro Thr Ser Pro Thr Ser Lys Tyr Asn 
145                 150                 155                 160 


Arg Asp Asn Glu Lys Val Gln Leu Leu Ala Arg Lys Ile Ile Phe Ser 
                165                 170                 175     


Tyr Leu Asn Leu Leu Val Asn Ser Lys Asn Asp Leu Ala Val Ala Tyr 
            180                 185                 190         


Ile Leu Asn Ile Pro Asp Arg Gly Leu Gly Arg Glu Ala Phe Thr Asp 
        195                 200                 205             


Leu Lys His Ala Ala Arg Glu Lys Gln Met Ser Ile Phe Leu Val Ala 
    210                 215                 220                 


Thr Ser Phe Ile Arg Thr Ile Glu Leu Gly Gly Lys Gly Tyr Ala Pro 
225                 230                 235                 240 


Pro Pro Ser Asp Pro Leu Arg Thr His Val Lys Gly Leu Ser Asn Phe 
                245                 250                 255     


Ile Asn Phe Ile Asp Lys Leu Asp Glu Ile Leu Gly Glu Ile Pro Asn 
            260                 265                 270         


Pro Ser Ile Ala Gly Gly Gln Ile Leu Ser Val Ile Lys Met Gln Leu 
        275                 280                 285             


Ile Lys Gly Gln Asn Ser Arg Asp Pro Phe Cys Lys Ala Ile Glu Glu 
    290                 295                 300                 


Val Ala Gln Asp Leu Asp Leu Arg Ile Lys Asn Ile Ile Asn Ser Gln 
305                 310                 315                 320 


Glu Gly Val Val Ala Leu Ser Thr Thr Asp Ile Ser Pro Ala Arg Pro 
                325                 330                 335     


Lys Ser His Ala Ile Asn His Gly Thr Ala Tyr Cys Gly Arg Asp Thr 
            340                 345                 350         


Val Lys Ala Leu Leu Val Leu Leu Asp Glu Glu Ala Ala Asn Ala Pro 
        355                 360                 365             


Thr Lys Asn Lys Ala Glu Leu Leu Tyr Asp Glu Glu Asn Thr Ile His 
    370                 375                 380                 


His His Gly Thr Ser Ile Leu Thr Leu Phe Arg Ser Pro Thr Gln Val 
385                 390                 395                 400 


Asn Asn Ser Ile Lys Pro Leu Arg Glu Arg Ile Cys Val Ser Met Gln 
                405                 410                 415     


Glu Lys Lys Ile Lys Met Lys Gln Thr Leu Ile Arg Ser Gln Phe Ala 
            420                 425                 430         


Cys Thr Tyr Lys Asp Asp Tyr Met Ile Ser Lys Asp Asn Trp Asn Asn 
        435                 440                 445             


Val Asn Leu Ala Ser Lys Pro Leu Cys Val Leu Tyr Met Glu Asn Asp 
    450                 455                 460                 


Leu Ser Glu Gly Val Asn Pro Ser Val Gly Arg Ser Thr Ile Gly Thr 
465                 470                 475                 480 


Ser Phe Gly Asn Val His Leu Asp Arg Ser Lys Asn Glu Lys Val Ser 
                485                 490                 495     


Arg Lys Ser Thr Ser Gln Thr Gly Asn Lys Ser Ser Lys Arg Lys Gln 
            500                 505                 510         


Val Asp Leu Asp Gly Glu Asn Ile Leu Cys Asp Asn Arg Asn Glu Pro 
        515                 520                 525             


Pro Gln His Lys Asn Ala Lys Ile Pro Lys Lys Ser Asn Asp Ser Gln 
    530                 535                 540                 


Asn Arg Leu Tyr Gly Lys Leu Ala Lys Val Ala Lys Ser Asn Lys Cys 
545                 550                 555                 560 


Thr Ala Lys Asp Lys Leu Ile Ser Gly Gln Ala Lys Leu Thr Gln Phe 
                565                 570                 575     


Phe Arg Leu 
            


<210>  345
<211>  6897
<212>  DNA
<213>  Homo sapiens

<400>  345
atggatccag aagagcagga gctcttaaat gattacagat acagaagcta ctcttcagtg       60

attgaaaagg ctttgagaaa ttttgagtcc tcgagtgaat gggcggatct catatcttca      120

cttggcaaac tcaacaaggc tcttcagagt aacctgaggt actccttgtt gccaagacgg      180

ctcctcatca gcaaaagatt agctcagtgt ttgcaccctg ccctgcccag tggtgtccac      240

ttaaaagctc tggaaaccta cgagattatc tttaaaatcg tggggaccaa atggctggcc      300

aaggacttgt ttctgtacag ctgcgggtta tttcctctcc tggcacacgc ggcggtgtcg      360

gtgaggccgg tgctgctcac cctgtacgag aagtacttcc tcccactgca gaagctgctc      420

ctgcccagtc tgcaggcctt catcgtgggc ctgctgcccg gccttgaaga gggctccgag      480

atctccgaca gaacggatgc tctgctcctg agactgtcgc tggtggttgg caaagaggtg      540

ttttacaccg ccctctgggg gagcgtcctg gccagcccgt ccatccgcct ccctgcctca      600

gtcttcgtgg tgggccacat caacagggat gcccccggcc gggagcagaa gtacatgctg      660

gggaccaatc accaactcac ggtgaagtct ttgcgtgcct ccctgttgga ctcaaatgtt      720

cttgtgcaaa gaaataatct ggaaatcgtt ctgtttttct tcccatttta tacctgtctg      780

gattccaatg agagagccat ccccctcctc agatctgaca tcgtgcgcat tctctcagcc      840

gccacccaga ccctactgag aagggacatg tccctgaaca gaagactgta tgcatggtta      900

ctaggctcag acataaaagg aaataccgtt gtgccagaat ctgaaatctc aaattcttat      960

gaagaccagt cgtcttattt ttttgaaaaa tactccaagg atcttttagt tgagggtttg     1020

gctgagatat tgcatcagaa gttcatagat gctgacgtgg aggaacgcca tcatgcatac     1080

ctgaagcctt ttcgcgtcct catcagtctg cttgacaagc cagaaatagg gcctcaagtg     1140

gttgggaatt tgtttctcga agtcatcagg gccttttatt cttactgcag agatgccctt     1200

ggctctgatc ttaaacttag ctacacccag agtggaaatt cgctgataag tgcaatcaag     1260

gaaaacagaa atgcctctga gattgtcaaa acggtaaatt tgctgataac ttctctaagc     1320

acagactttc tctgggatta tatgacaagg tgttttgagg aatgctttag accagtgaag     1380

cagcgttaca gcgtgaggaa cagcgtcagc cctcccccca cggtctcgga gctctgcgcc     1440

ctcctggtct tcctgctgga tgtcattcct ttggaacttt actctgaggt gcaaacccag     1500

tatctccctc aggtgctcgg ctgcctggtg cagcctcttg ctgaggacat ggaggcctta     1560

agtttacctg aactcacgca tgccttgaag acgtgtttca aggtgctcag caaagtccag     1620

atgcctcctt cctacctcga cacggagtcc accagcggaa cctcgagtcc agtaaaaggt     1680

gaaaacggca aaataatttt ggaaacaaag gcagtgattc ccggtgacga agatgcttcg     1740

tttccccctc tgaagtctga ggacagtggg atcgggctca gtgcctcgtc accggagctc     1800

tctgagcact tgagggttcc tcgagtttct ctggaaaggg acgacgtttg gaagaagggc     1860

gggagcatgc agaggacgtt tctttgcatc caagagctaa tcgccaactt tgccagcaag     1920

aacatttttg gagtacagct gacagcgtca ggagaagaaa gcaagtccga ggagcctgca     1980

gggaagaggg acagggatgg gacgcagagc ctggcagcca atgattccag caggaagaac     2040

tcttgggagc ccaagcccat cactgtgcct cagttcaagc agatgctgtc agacttgttc     2100

acagcacgag ggtctccatt caagacaaaa agttcagagt caccatcgtc ttcgcccagc     2160

agccctgcca ggaaaaacgg gggagaatgg gatgttgaga aggtggtcat tgacctgggg     2220

ggttccaggg aggaacgcag ggaggccttt gccgccgcct gccacctgct gctggattgt     2280

gccactttcc ctgtctacct gtccgaggaa gagaccgagc agctctgtgc aacgctcttc     2340

cagctgccag gagccggtga ttccagtttt ccatcttggc tgaagtccct catgactatt     2400

tgctgctgtg tgactgactg ctacctccag aacgtggcca tttccactct gctggaagtg     2460

ataaaccatt cccagtccct ggcgcttgtc attgaagaca agatgaaacg ctataagagc     2520

tctggacaca accctttttt tggcaagctg cagatggtga cggttcctcc cattgctcca     2580

gggatattga aagtcattgc agagaaaaca gatttctatc agagggtggc tcgtgtgctt     2640

tggaatcagc tgaacaaaga gacccgggag catcacgtca cctgcgtaga attgttctac     2700

cggctgcact gcctggcccc tacggccaac atctgcgagg acatcatctg ccatgccctc     2760

ctggaccctg acaagggaac aaggctggaa gctctgttta gattttccgt gatctggcat     2820

ctgacaagag agatccaagg cagtcgagta acatctcaca atcgctcctt tgataggtcc     2880

ttgtttgtcg tgctggacag cctggcctgc acggatggtg ccatcggtgc ggcagcccag     2940

ggctggctgg tgcgtgcgct ctccctcggg gacgtggctc gcatcctcga acccgtgctc     3000

ctgctgctgc tgcagccaaa aacccagaga acctccatcc actgcctcaa gcaggagaac     3060

tcggccgatg acttgcaccg ttggtttaac aggaagaaaa cctctttcag agaggcatgc     3120

gcagtgcccg agcctcagga gagcggctct gaagagcacc tgcctctgag ccagttcacc     3180

acagtggacc gtgaagccat ttgggccgaa gtggagaagg agcccgagaa gtacccgctg     3240

cgaggcgagc tgagcgagga agagctgccc tactacgtgg agcttccaga caggacggcc     3300

cacggcgccc cggacagcag cgagcacacc gagtctgcag atacaagctc ctgccacacg     3360

gacagcgaga acacgtcctc cttctcctcc ccttcccacg acctgcagga gctgagcaac     3420

gaagagaact gctgtgcacc catccccatg gggggcaggg cgtaccccaa gcgctcggcc     3480

ctgctggcgg ccttccagtc agaaagcttc aaggctgggg ccaagttaag cctggtgcgg     3540

gtggactcgg acaagacgca ggcttctgag tcgttctcca gcgacgagga ggcggacttg     3600

gagctccagg ccctcaccac atccaggctg ctaaagcagc agcgggaaag gcaggaggcc     3660

gtcgaggcct tgttcaagca catcctgctc tacctgcagc cctacgactc tcggcgggtc     3720

ctctatgcct tctcggtgct ggaggctgtg ctcaaaacca accctaagga attcatcgag     3780

gctgtgtcca ggactagcat ggataccagc tccaccgcgc acctcaacct catctccaac     3840

ctcctcgctc gccaccagga ggccctcatt ggccagagtt tctacggaaa gctccagacc     3900

caggtcccca acgtgtgccc ccactctctg ctcctggagc tgctcaccta cctctgcctg     3960

agcttcctgc gctcctacta cccttgctat ttgaaggtct cgcaccgaga cattctcggc     4020

aaccgggacg tgcaggtcaa aagtgtcgag gttttgatca ggataatgat gcagctggtc     4080

tcagtggcca agtcttcgga agggaagaac gtggagttca tccacagctt gctgcagagg     4140

tgcaaagttc aggagtttgt cctgctctcc ctgtcggcgt ccatgtacac gagccagaag     4200

cgctacgggc tggccaccgc ccaccacggc agggccctgc cagaggacag cctctttgag     4260

gagagtctca ttaacttggg tcaggaccag atctggagtg agcacccgct gcagattgag     4320

ctgctgaagc tgctgcaggt gctgattgtc ttggaacacc acctgggtcg ggcccatgag     4380

gaggcggaaa accagcccga cctgtcccgg gagtggcaga gagccctgaa cttccagcag     4440

gccatcagcg ccctgcagta cgtgcagccc caccccctca cctcccaggg tcttctggtc     4500

tctgcggtgg tgaggggtct gcagcccgcc tacggttacg gcatgcatcc ggcctgggtg     4560

agcttggtca cgcattcctt gccctacttc ggaaagtccc tgggctggac ggtgacaccc     4620

tttgttgtcc agatttgcaa aaacttggat gacttggtca agcagtatga aagcgaatct     4680

gtgaagctct ctgtcagcac aacctccaag agggaaaaca tttctccaga ttatccactc     4740

acccttctag aaggtctaac gaccattagt catttttgtc ttttggaaca agccaaccaa     4800

aacaaaaaga ccatggctgc aggtgatcct gccaacttga ggaatgccag aaatgccatt     4860

ttggaagagc tgcctcgaac tgttaacacc atggcccttc tctggaatgt tctcagaaag     4920

gaggagactc aaaagagacc tgtcgatctc ctaggggcca cgaagggatc ctcttccgtt     4980

tactttaaaa ccaccaaaac cataagacaa aaaattttag acttcttaaa ccccttgacg     5040

gcccatcttg gggttcagtt gacagcggct gttgcggcag tgtggagcag aaagaaagcc     5100

cagcgtcaca gtaagatgaa gattatccca acggcaagtg catcccagct aacccttgtc     5160

gacttggtgt gtgcactcag caccctgcag actgacacgc tgctgcacct ggtgaaggag     5220

gtggtgaaga ggccacccca agtcaaaggg ggtgatgaga aatcgcccct agtggacatt     5280

cctgtgttgc agttttgcta tgcttttctc caaaggctcc cagtaccagc cttgcaagag     5340

aacttttctt cactgttggg agtattgaaa gagtctgtac agttgaatct agccccacct     5400

gggtattttc tgcttctcag catgctgaat gactttgtaa caagaactcc caacctggaa     5460

aacaagaagg accaaaaaga cctgcaggaa atcactcaga aaatcctaga agctgtgggg     5520

aacattgccg gctcttcctt ggagcaaacc agctggctaa gcagaaacct ggaagtgaag     5580

gcccaacctc aggcctctct agaagaatct gatgctgagg aggacctgta tgatgctgct     5640

gcagcttcag caatggtgtc ttcatccgcc ccgtcggtgt acagcgtgca agccctctct     5700

ctcctggcag aggtactggc ttccctcctg gacatggttt atcgaagtga tgagaaggag     5760

aaagctgtgc cgttaatctc ccgtctgctt tactatgttt ttccatactt acgcaaccac     5820

agtgcctaca atgctcccag cttccgggct ggcgctcagc tgctgagctc cctgagtggc     5880

tatgcctaca caaagcgagc ctggaggaag gaggtcctgg agctgtttct cgaccccgct     5940

ttctttcaga tggatacttc ctgtgttcat tggaagtcca ttattgacca tcttttgact     6000

catgagaaaa caatgtttaa ggatttaatg aacatgcaga gcagttcttt gaaactattc     6060

tcaagttttg aacagaaagc catgctgtta aagcgccagg cttttgctgt cttcagtgga     6120

gaacttgatc aataccacct ttaccttcca ctgatacaag aacgcctgac agacaatctc     6180

agagttggac agacatccat agttgctgct cagatgtttc tttttttcag agttttgctg     6240

ctaagaatat ctcctcaaca tttgacttca ttgtggccaa taatggtctc tgaattgatt     6300

cagacattca cacagcttga agaagatcta aaagatgaag atgagtcatt gagaagcacc     6360

aacaaagtaa acagaacgaa agtttcagtc ccggatgcaa atggaccctc agtgggggag     6420

ataccccaga gtgaactcat cttgtattta tcagcttgca aattcttgga cacagcgctt     6480

tcttttccac ctgacaagat gccattattt caaatttata ggtgggcatt tattccagaa     6540

gtggacacag agggccctgc cttcctgtcg gatgtagagg agaatcacca agaatgcaaa     6600

ccccacactg tcaggattct agaacttcta aaattaaagt ttggggaaat cagtagctct     6660

gatgagatca ccatgaagag tgaattcccg cttctgcgcc aacattctgt ttccagcatc     6720

aggcagttga tgccattctt catgactcta aatggtgcat ttaagaccca gagacagctg     6780

cctgctgata gcccaggaac tccattcttg gactttcctg tcacagatag cccaaggatc     6840

ttaaaacaac tggaagaatg catcgaatat gattttctgg aacatccaga atgttaa        6897


<210>  346
<211>  2298
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Asp Pro Glu Glu Gln Glu Leu Leu Asn Asp Tyr Arg Tyr Arg Ser 
1               5                   10                  15      


Tyr Ser Ser Val Ile Glu Lys Ala Leu Arg Asn Phe Glu Ser Ser Ser 
            20                  25                  30          


Glu Trp Ala Asp Leu Ile Ser Ser Leu Gly Lys Leu Asn Lys Ala Leu 
        35                  40                  45              


Gln Ser Asn Leu Arg Tyr Ser Leu Leu Pro Arg Arg Leu Leu Ile Ser 
    50                  55                  60                  


Lys Arg Leu Ala Gln Cys Leu His Pro Ala Leu Pro Ser Gly Val His 
65                  70                  75                  80  


Leu Lys Ala Leu Glu Thr Tyr Glu Ile Ile Phe Lys Ile Val Gly Thr 
                85                  90                  95      


Lys Trp Leu Ala Lys Asp Leu Phe Leu Tyr Ser Cys Gly Leu Phe Pro 
            100                 105                 110         


Leu Leu Ala His Ala Ala Val Ser Val Arg Pro Val Leu Leu Thr Leu 
        115                 120                 125             


Tyr Glu Lys Tyr Phe Leu Pro Leu Gln Lys Leu Leu Leu Pro Ser Leu 
    130                 135                 140                 


Gln Ala Phe Ile Val Gly Leu Leu Pro Gly Leu Glu Glu Gly Ser Glu 
145                 150                 155                 160 


Ile Ser Asp Arg Thr Asp Ala Leu Leu Leu Arg Leu Ser Leu Val Val 
                165                 170                 175     


Gly Lys Glu Val Phe Tyr Thr Ala Leu Trp Gly Ser Val Leu Ala Ser 
            180                 185                 190         


Pro Ser Ile Arg Leu Pro Ala Ser Val Phe Val Val Gly His Ile Asn 
        195                 200                 205             


Arg Asp Ala Pro Gly Arg Glu Gln Lys Tyr Met Leu Gly Thr Asn His 
    210                 215                 220                 


Gln Leu Thr Val Lys Ser Leu Arg Ala Ser Leu Leu Asp Ser Asn Val 
225                 230                 235                 240 


Leu Val Gln Arg Asn Asn Leu Glu Ile Val Leu Phe Phe Phe Pro Phe 
                245                 250                 255     


Tyr Thr Cys Leu Asp Ser Asn Glu Arg Ala Ile Pro Leu Leu Arg Ser 
            260                 265                 270         


Asp Ile Val Arg Ile Leu Ser Ala Ala Thr Gln Thr Leu Leu Arg Arg 
        275                 280                 285             


Asp Met Ser Leu Asn Arg Arg Leu Tyr Ala Trp Leu Leu Gly Ser Asp 
    290                 295                 300                 


Ile Lys Gly Asn Thr Val Val Pro Glu Ser Glu Ile Ser Asn Ser Tyr 
305                 310                 315                 320 


Glu Asp Gln Ser Ser Tyr Phe Phe Glu Lys Tyr Ser Lys Asp Leu Leu 
                325                 330                 335     


Val Glu Gly Leu Ala Glu Ile Leu His Gln Lys Phe Ile Asp Ala Asp 
            340                 345                 350         


Val Glu Glu Arg His His Ala Tyr Leu Lys Pro Phe Arg Val Leu Ile 
        355                 360                 365             


Ser Leu Leu Asp Lys Pro Glu Ile Gly Pro Gln Val Val Gly Asn Leu 
    370                 375                 380                 


Phe Leu Glu Val Ile Arg Ala Phe Tyr Ser Tyr Cys Arg Asp Ala Leu 
385                 390                 395                 400 


Gly Ser Asp Leu Lys Leu Ser Tyr Thr Gln Ser Gly Asn Ser Leu Ile 
                405                 410                 415     


Ser Ala Ile Lys Glu Asn Arg Asn Ala Ser Glu Ile Val Lys Thr Val 
            420                 425                 430         


Asn Leu Leu Ile Thr Ser Leu Ser Thr Asp Phe Leu Trp Asp Tyr Met 
        435                 440                 445             


Thr Arg Cys Phe Glu Glu Cys Phe Arg Pro Val Lys Gln Arg Tyr Ser 
    450                 455                 460                 


Val Arg Asn Ser Val Ser Pro Pro Pro Thr Val Ser Glu Leu Cys Ala 
465                 470                 475                 480 


Leu Leu Val Phe Leu Leu Asp Val Ile Pro Leu Glu Leu Tyr Ser Glu 
                485                 490                 495     


Val Gln Thr Gln Tyr Leu Pro Gln Val Leu Gly Cys Leu Val Gln Pro 
            500                 505                 510         


Leu Ala Glu Asp Met Glu Ala Leu Ser Leu Pro Glu Leu Thr His Ala 
        515                 520                 525             


Leu Lys Thr Cys Phe Lys Val Leu Ser Lys Val Gln Met Pro Pro Ser 
    530                 535                 540                 


Tyr Leu Asp Thr Glu Ser Thr Ser Gly Thr Ser Ser Pro Val Lys Gly 
545                 550                 555                 560 


Glu Asn Gly Lys Ile Ile Leu Glu Thr Lys Ala Val Ile Pro Gly Asp 
                565                 570                 575     


Glu Asp Ala Ser Phe Pro Pro Leu Lys Ser Glu Asp Ser Gly Ile Gly 
            580                 585                 590         


Leu Ser Ala Ser Ser Pro Glu Leu Ser Glu His Leu Arg Val Pro Arg 
        595                 600                 605             


Val Ser Leu Glu Arg Asp Asp Val Trp Lys Lys Gly Gly Ser Met Gln 
    610                 615                 620                 


Arg Thr Phe Leu Cys Ile Gln Glu Leu Ile Ala Asn Phe Ala Ser Lys 
625                 630                 635                 640 


Asn Ile Phe Gly Val Gln Leu Thr Ala Ser Gly Glu Glu Ser Lys Ser 
                645                 650                 655     


Glu Glu Pro Ala Gly Lys Arg Asp Arg Asp Gly Thr Gln Ser Leu Ala 
            660                 665                 670         


Ala Asn Asp Ser Ser Arg Lys Asn Ser Trp Glu Pro Lys Pro Ile Thr 
        675                 680                 685             


Val Pro Gln Phe Lys Gln Met Leu Ser Asp Leu Phe Thr Ala Arg Gly 
    690                 695                 700                 


Ser Pro Phe Lys Thr Lys Ser Ser Glu Ser Pro Ser Ser Ser Pro Ser 
705                 710                 715                 720 


Ser Pro Ala Arg Lys Asn Gly Gly Glu Trp Asp Val Glu Lys Val Val 
                725                 730                 735     


Ile Asp Leu Gly Gly Ser Arg Glu Glu Arg Arg Glu Ala Phe Ala Ala 
            740                 745                 750         


Ala Cys His Leu Leu Leu Asp Cys Ala Thr Phe Pro Val Tyr Leu Ser 
        755                 760                 765             


Glu Glu Glu Thr Glu Gln Leu Cys Ala Thr Leu Phe Gln Leu Pro Gly 
    770                 775                 780                 


Ala Gly Asp Ser Ser Phe Pro Ser Trp Leu Lys Ser Leu Met Thr Ile 
785                 790                 795                 800 


Cys Cys Cys Val Thr Asp Cys Tyr Leu Gln Asn Val Ala Ile Ser Thr 
                805                 810                 815     


Leu Leu Glu Val Ile Asn His Ser Gln Ser Leu Ala Leu Val Ile Glu 
            820                 825                 830         


Asp Lys Met Lys Arg Tyr Lys Ser Ser Gly His Asn Pro Phe Phe Gly 
        835                 840                 845             


Lys Leu Gln Met Val Thr Val Pro Pro Ile Ala Pro Gly Ile Leu Lys 
    850                 855                 860                 


Val Ile Ala Glu Lys Thr Asp Phe Tyr Gln Arg Val Ala Arg Val Leu 
865                 870                 875                 880 


Trp Asn Gln Leu Asn Lys Glu Thr Arg Glu His His Val Thr Cys Val 
                885                 890                 895     


Glu Leu Phe Tyr Arg Leu His Cys Leu Ala Pro Thr Ala Asn Ile Cys 
            900                 905                 910         


Glu Asp Ile Ile Cys His Ala Leu Leu Asp Pro Asp Lys Gly Thr Arg 
        915                 920                 925             


Leu Glu Ala Leu Phe Arg Phe Ser Val Ile Trp His Leu Thr Arg Glu 
    930                 935                 940                 


Ile Gln Gly Ser Arg Val Thr Ser His Asn Arg Ser Phe Asp Arg Ser 
945                 950                 955                 960 


Leu Phe Val Val Leu Asp Ser Leu Ala Cys Thr Asp Gly Ala Ile Gly 
                965                 970                 975     


Ala Ala Ala Gln Gly Trp Leu Val Arg Ala Leu Ser Leu Gly Asp Val 
            980                 985                 990         


Ala Arg Ile Leu Glu Pro Val Leu  Leu Leu Leu Leu Gln  Pro Lys Thr 
        995                 1000                 1005             


Gln Arg  Thr Ser Ile His Cys  Leu Lys Gln Glu Asn  Ser Ala Asp 
    1010                 1015                 1020             


Asp Leu  His Arg Trp Phe Asn  Arg Lys Lys Thr Ser  Phe Arg Glu 
    1025                 1030                 1035             


Ala Cys  Ala Val Pro Glu Pro  Gln Glu Ser Gly Ser  Glu Glu His 
    1040                 1045                 1050             


Leu Pro  Leu Ser Gln Phe Thr  Thr Val Asp Arg Glu  Ala Ile Trp 
    1055                 1060                 1065             


Ala Glu  Val Glu Lys Glu Pro  Glu Lys Tyr Pro Leu  Arg Gly Glu 
    1070                 1075                 1080             


Leu Ser  Glu Glu Glu Leu Pro  Tyr Tyr Val Glu Leu  Pro Asp Arg 
    1085                 1090                 1095             


Thr Ala  His Gly Ala Pro Asp  Ser Ser Glu His Thr  Glu Ser Ala 
    1100                 1105                 1110             


Asp Thr  Ser Ser Cys His Thr  Asp Ser Glu Asn Thr  Ser Ser Phe 
    1115                 1120                 1125             


Ser Ser  Pro Ser His Asp Leu  Gln Glu Leu Ser Asn  Glu Glu Asn 
    1130                 1135                 1140             


Cys Cys  Ala Pro Ile Pro Met  Gly Gly Arg Ala Tyr  Pro Lys Arg 
    1145                 1150                 1155             


Ser Ala  Leu Leu Ala Ala Phe  Gln Ser Glu Ser Phe  Lys Ala Gly 
    1160                 1165                 1170             


Ala Lys  Leu Ser Leu Val Arg  Val Asp Ser Asp Lys  Thr Gln Ala 
    1175                 1180                 1185             


Ser Glu  Ser Phe Ser Ser Asp  Glu Glu Ala Asp Leu  Glu Leu Gln 
    1190                 1195                 1200             


Ala Leu  Thr Thr Ser Arg Leu  Leu Lys Gln Gln Arg  Glu Arg Gln 
    1205                 1210                 1215             


Glu Ala  Val Glu Ala Leu Phe  Lys His Ile Leu Leu  Tyr Leu Gln 
    1220                 1225                 1230             


Pro Tyr  Asp Ser Arg Arg Val  Leu Tyr Ala Phe Ser  Val Leu Glu 
    1235                 1240                 1245             


Ala Val  Leu Lys Thr Asn Pro  Lys Glu Phe Ile Glu  Ala Val Ser 
    1250                 1255                 1260             


Arg Thr  Ser Met Asp Thr Ser  Ser Thr Ala His Leu  Asn Leu Ile 
    1265                 1270                 1275             


Ser Asn  Leu Leu Ala Arg His  Gln Glu Ala Leu Ile  Gly Gln Ser 
    1280                 1285                 1290             


Phe Tyr  Gly Lys Leu Gln Thr  Gln Val Pro Asn Val  Cys Pro His 
    1295                 1300                 1305             


Ser Leu  Leu Leu Glu Leu Leu  Thr Tyr Leu Cys Leu  Ser Phe Leu 
    1310                 1315                 1320             


Arg Ser  Tyr Tyr Pro Cys Tyr  Leu Lys Val Ser His  Arg Asp Ile 
    1325                 1330                 1335             


Leu Gly  Asn Arg Asp Val Gln  Val Lys Ser Val Glu  Val Leu Ile 
    1340                 1345                 1350             


Arg Ile  Met Met Gln Leu Val  Ser Val Ala Lys Ser  Ser Glu Gly 
    1355                 1360                 1365             


Lys Asn  Val Glu Phe Ile His  Ser Leu Leu Gln Arg  Cys Lys Val 
    1370                 1375                 1380             


Gln Glu  Phe Val Leu Leu Ser  Leu Ser Ala Ser Met  Tyr Thr Ser 
    1385                 1390                 1395             


Gln Lys  Arg Tyr Gly Leu Ala  Thr Ala His His Gly  Arg Ala Leu 
    1400                 1405                 1410             


Pro Glu  Asp Ser Leu Phe Glu  Glu Ser Leu Ile Asn  Leu Gly Gln 
    1415                 1420                 1425             


Asp Gln  Ile Trp Ser Glu His  Pro Leu Gln Ile Glu  Leu Leu Lys 
    1430                 1435                 1440             


Leu Leu  Gln Val Leu Ile Val  Leu Glu His His Leu  Gly Arg Ala 
    1445                 1450                 1455             


His Glu  Glu Ala Glu Asn Gln  Pro Asp Leu Ser Arg  Glu Trp Gln 
    1460                 1465                 1470             


Arg Ala  Leu Asn Phe Gln Gln  Ala Ile Ser Ala Leu  Gln Tyr Val 
    1475                 1480                 1485             


Gln Pro  His Pro Leu Thr Ser  Gln Gly Leu Leu Val  Ser Ala Val 
    1490                 1495                 1500             


Val Arg  Gly Leu Gln Pro Ala  Tyr Gly Tyr Gly Met  His Pro Ala 
    1505                 1510                 1515             


Trp Val  Ser Leu Val Thr His  Ser Leu Pro Tyr Phe  Gly Lys Ser 
    1520                 1525                 1530             


Leu Gly  Trp Thr Val Thr Pro  Phe Val Val Gln Ile  Cys Lys Asn 
    1535                 1540                 1545             


Leu Asp  Asp Leu Val Lys Gln  Tyr Glu Ser Glu Ser  Val Lys Leu 
    1550                 1555                 1560             


Ser Val  Ser Thr Thr Ser Lys  Arg Glu Asn Ile Ser  Pro Asp Tyr 
    1565                 1570                 1575             


Pro Leu  Thr Leu Leu Glu Gly  Leu Thr Thr Ile Ser  His Phe Cys 
    1580                 1585                 1590             


Leu Leu  Glu Gln Ala Asn Gln  Asn Lys Lys Thr Met  Ala Ala Gly 
    1595                 1600                 1605             


Asp Pro  Ala Asn Leu Arg Asn  Ala Arg Asn Ala Ile  Leu Glu Glu 
    1610                 1615                 1620             


Leu Pro  Arg Thr Val Asn Thr  Met Ala Leu Leu Trp  Asn Val Leu 
    1625                 1630                 1635             


Arg Lys  Glu Glu Thr Gln Lys  Arg Pro Val Asp Leu  Leu Gly Ala 
    1640                 1645                 1650             


Thr Lys  Gly Ser Ser Ser Val  Tyr Phe Lys Thr Thr  Lys Thr Ile 
    1655                 1660                 1665             


Arg Gln  Lys Ile Leu Asp Phe  Leu Asn Pro Leu Thr  Ala His Leu 
    1670                 1675                 1680             


Gly Val  Gln Leu Thr Ala Ala  Val Ala Ala Val Trp  Ser Arg Lys 
    1685                 1690                 1695             


Lys Ala  Gln Arg His Ser Lys  Met Lys Ile Ile Pro  Thr Ala Ser 
    1700                 1705                 1710             


Ala Ser  Gln Leu Thr Leu Val  Asp Leu Val Cys Ala  Leu Ser Thr 
    1715                 1720                 1725             


Leu Gln  Thr Asp Thr Leu Leu  His Leu Val Lys Glu  Val Val Lys 
    1730                 1735                 1740             


Arg Pro  Pro Gln Val Lys Gly  Gly Asp Glu Lys Ser  Pro Leu Val 
    1745                 1750                 1755             


Asp Ile  Pro Val Leu Gln Phe  Cys Tyr Ala Phe Leu  Gln Arg Leu 
    1760                 1765                 1770             


Pro Val  Pro Ala Leu Gln Glu  Asn Phe Ser Ser Leu  Leu Gly Val 
    1775                 1780                 1785             


Leu Lys  Glu Ser Val Gln Leu  Asn Leu Ala Pro Pro  Gly Tyr Phe 
    1790                 1795                 1800             


Leu Leu  Leu Ser Met Leu Asn  Asp Phe Val Thr Arg  Thr Pro Asn 
    1805                 1810                 1815             


Leu Glu  Asn Lys Lys Asp Gln  Lys Asp Leu Gln Glu  Ile Thr Gln 
    1820                 1825                 1830             


Lys Ile  Leu Glu Ala Val Gly  Asn Ile Ala Gly Ser  Ser Leu Glu 
    1835                 1840                 1845             


Gln Thr  Ser Trp Leu Ser Arg  Asn Leu Glu Val Lys  Ala Gln Pro 
    1850                 1855                 1860             


Gln Ala  Ser Leu Glu Glu Ser  Asp Ala Glu Glu Asp  Leu Tyr Asp 
    1865                 1870                 1875             


Ala Ala  Ala Ala Ser Ala Met  Val Ser Ser Ser Ala  Pro Ser Val 
    1880                 1885                 1890             


Tyr Ser  Val Gln Ala Leu Ser  Leu Leu Ala Glu Val  Leu Ala Ser 
    1895                 1900                 1905             


Leu Leu  Asp Met Val Tyr Arg  Ser Asp Glu Lys Glu  Lys Ala Val 
    1910                 1915                 1920             


Pro Leu  Ile Ser Arg Leu Leu  Tyr Tyr Val Phe Pro  Tyr Leu Arg 
    1925                 1930                 1935             


Asn His  Ser Ala Tyr Asn Ala  Pro Ser Phe Arg Ala  Gly Ala Gln 
    1940                 1945                 1950             


Leu Leu  Ser Ser Leu Ser Gly  Tyr Ala Tyr Thr Lys  Arg Ala Trp 
    1955                 1960                 1965             


Arg Lys  Glu Val Leu Glu Leu  Phe Leu Asp Pro Ala  Phe Phe Gln 
    1970                 1975                 1980             


Met Asp  Thr Ser Cys Val His  Trp Lys Ser Ile Ile  Asp His Leu 
    1985                 1990                 1995             


Leu Thr  His Glu Lys Thr Met  Phe Lys Asp Leu Met  Asn Met Gln 
    2000                 2005                 2010             


Ser Ser  Ser Leu Lys Leu Phe  Ser Ser Phe Glu Gln  Lys Ala Met 
    2015                 2020                 2025             


Leu Leu  Lys Arg Gln Ala Phe  Ala Val Phe Ser Gly  Glu Leu Asp 
    2030                 2035                 2040             


Gln Tyr  His Leu Tyr Leu Pro  Leu Ile Gln Glu Arg  Leu Thr Asp 
    2045                 2050                 2055             


Asn Leu  Arg Val Gly Gln Thr  Ser Ile Val Ala Ala  Gln Met Phe 
    2060                 2065                 2070             


Leu Phe  Phe Arg Val Leu Leu  Leu Arg Ile Ser Pro  Gln His Leu 
    2075                 2080                 2085             


Thr Ser  Leu Trp Pro Ile Met  Val Ser Glu Leu Ile  Gln Thr Phe 
    2090                 2095                 2100             


Thr Gln  Leu Glu Glu Asp Leu  Lys Asp Glu Asp Glu  Ser Leu Arg 
    2105                 2110                 2115             


Ser Thr  Asn Lys Val Asn Arg  Thr Lys Val Ser Val  Pro Asp Ala 
    2120                 2125                 2130             


Asn Gly  Pro Ser Val Gly Glu  Ile Pro Gln Ser Glu  Leu Ile Leu 
    2135                 2140                 2145             


Tyr Leu  Ser Ala Cys Lys Phe  Leu Asp Thr Ala Leu  Ser Phe Pro 
    2150                 2155                 2160             


Pro Asp  Lys Met Pro Leu Phe  Gln Ile Tyr Arg Trp  Ala Phe Ile 
    2165                 2170                 2175             


Pro Glu  Val Asp Thr Glu Gly  Pro Ala Phe Leu Ser  Asp Val Glu 
    2180                 2185                 2190             


Glu Asn  His Gln Glu Cys Lys  Pro His Thr Val Arg  Ile Leu Glu 
    2195                 2200                 2205             


Leu Leu  Lys Leu Lys Phe Gly  Glu Ile Ser Ser Ser  Asp Glu Ile 
    2210                 2215                 2220             


Thr Met  Lys Ser Glu Phe Pro  Leu Leu Arg Gln His  Ser Val Ser 
    2225                 2230                 2235             


Ser Ile  Arg Gln Leu Met Pro  Phe Phe Met Thr Leu  Asn Gly Ala 
    2240                 2245                 2250             


Phe Lys  Thr Gln Arg Gln Leu  Pro Ala Asp Ser Pro  Gly Thr Pro 
    2255                 2260                 2265             


Phe Leu  Asp Phe Pro Val Thr  Asp Ser Pro Arg Ile  Leu Lys Gln 
    2270                 2275                 2280             


Leu Glu  Glu Cys Ile Glu Tyr  Asp Phe Leu Glu His  Pro Glu Cys 
    2285                 2290                 2295             


<210>  347
<211>  2124
<212>  DNA
<213>  Homo sapiens

<400>  347
atgccggagg aggcgggctt cccgccggcc aagagattcc ggccaggctc tggacctccg       60

agccgcgctg ggtccttccc tcccgggagg caagtggtga tgctgctgac tgcgggcagc      120

ggcggcagag gaggaggagg aggccggagg cagcagccgc ccctggccca gccctcggcc      180

agtccctacc ctgaagctgt ggagctgcag cgccggagtc tgcccatctt ccaagcgcgg      240

gggcaactgt tggcccagct ccgaaacctg gacaacgcgg tcctcatcgg ggaaactggc      300

tctgggaaga caactcagat ccctcagtac ctgtatgaag gagggatcag ccgccagggc      360

atcattgctg tgacccagcc tcgtcgagta gctgccatct ctcttgctac tagagtctca      420

gatgagaaga gaactgaact tgggaagctg gttggctata cagtgcgctt tgatgatgtc      480

acctcagaag acaccaggat caagtttctg acagatggca tgcttctgcg tgaagcaatt      540

tcagactctt tgcttcggaa atacagctgt gtcattttgg atgaagctca cgaacggact      600

atccacacag atgtgctctt tggagtggtg aaagctgcac agaagaggag aaaggaactc      660

gggaaacttc ctctgaaagt gattgtgatg tcagctacga tggatgtgga cctgttctct      720

cagtatttca atggcgcccc cgtcctctac ctagagggtc ggcagcatcc gatccaggtg      780

ttttacacca aacagcctca gaatgattac ctgcacgccg cgcttgtctc cgtcttccag      840

atccaccagg aagccccttc ttcacaggac atcctggtgt tcctcactgg gcaggaggag      900

atcgaagcca tgagcaagac gtgccgagac attgcaaagc acctcccaga cggctgccct      960

gcgatgctgg tccttcctct gtacgcctcc ctgccctatg cacagcagct ccgagtcttc     1020

caaggggccc caaagggcta tcgcaaagtg atcatttcaa ccaacatcgc tgaaacctcc     1080

ataaccatta caggaataaa atatgtagtt gacacgggca tggttaaagc aaagaagtat     1140

aaccctgaca gtggtcttga ggtgttagca gtgcagcggg tatcgaagac gcaggcttgg     1200

cagcgcacag ggagggctgg cagagaggac agtggcatct gctaccggct ctacacggag     1260

gacgagtttg agaagtttga taagatgacc gtgccagaga tccagaggtg taacctggcc     1320

agtgtgatgc ttcagcttct agcaatgaaa gtcccaaatg tgctcacctt tgacttcatg     1380

tcgaagccat ctccagatca cattcaggcg gccattgccc aactggacct gttaggtgct     1440

cttgaacata aggatgacca gcttaccctg actccaatgg gaagaaagat ggcagcattt     1500

cctttagaac ccaaatttgc caaaaccatc ctcatgtccc ccaaattcca ctgtacagag     1560

gagatcctga ccattgtctc cctgctgtct gtggacagcg tcctccacaa ccctccttcc     1620

cggcgagagg aagtgcaagg ggtccgcaag aagttcatat ccagcgaggg ggatcacatg     1680

accctgctca atatctatcg gaccttcaaa aacctaggcg gaaataagga ttggtgcaaa     1740

gagaattttg tcaacagcaa gaatatgacg ctggtagcag aagtcagagc acagctgagg     1800

gacatctgct taaagatgtc aatgccaatc gcatcatccc gaggagacgt ggagagtgtc     1860

cgccgctgcc tggctcacag cctcttcatg agcaccgccg agcttcagcc agatggcacc     1920

tatgccacca cggacaccca ccagccagtg gccatccacc cgtcgtctgt cctcttccac     1980

tgcaagccgg cctgcgtcgt gtacactgag ctgctctaca ccaacaagtg ctacatgcgg     2040

gacctctgcg tcatagatgc acagtggctg tacgaggctg cccctgagta ctttaggagg     2100

aagctgagaa ccgccagaaa ctga                                            2124


<210>  348
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Pro Glu Glu Ala Gly Phe Pro Pro Ala Lys Arg Phe Arg Pro Gly 
1               5                   10                  15      


Ser Gly Pro Pro Ser Arg Ala Gly Ser Phe Pro Pro Gly Arg Gln Val 
            20                  25                  30          


Val Met Leu Leu Thr Ala Gly Ser Gly Gly Arg Gly Gly Gly Gly Gly 
        35                  40                  45              


Arg Arg Gln Gln Pro Pro Leu Ala Gln Pro Ser Ala Ser Pro Tyr Pro 
    50                  55                  60                  


Glu Ala Val Glu Leu Gln Arg Arg Ser Leu Pro Ile Phe Gln Ala Arg 
65                  70                  75                  80  


Gly Gln Leu Leu Ala Gln Leu Arg Asn Leu Asp Asn Ala Val Leu Ile 
                85                  90                  95      


Gly Glu Thr Gly Ser Gly Lys Thr Thr Gln Ile Pro Gln Tyr Leu Tyr 
            100                 105                 110         


Glu Gly Gly Ile Ser Arg Gln Gly Ile Ile Ala Val Thr Gln Pro Arg 
        115                 120                 125             


Arg Val Ala Ala Ile Ser Leu Ala Thr Arg Val Ser Asp Glu Lys Arg 
    130                 135                 140                 


Thr Glu Leu Gly Lys Leu Val Gly Tyr Thr Val Arg Phe Asp Asp Val 
145                 150                 155                 160 


Thr Ser Glu Asp Thr Arg Ile Lys Phe Leu Thr Asp Gly Met Leu Leu 
                165                 170                 175     


Arg Glu Ala Ile Ser Asp Ser Leu Leu Arg Lys Tyr Ser Cys Val Ile 
            180                 185                 190         


Leu Asp Glu Ala His Glu Arg Thr Ile His Thr Asp Val Leu Phe Gly 
        195                 200                 205             


Val Val Lys Ala Ala Gln Lys Arg Arg Lys Glu Leu Gly Lys Leu Pro 
    210                 215                 220                 


Leu Lys Val Ile Val Met Ser Ala Thr Met Asp Val Asp Leu Phe Ser 
225                 230                 235                 240 


Gln Tyr Phe Asn Gly Ala Pro Val Leu Tyr Leu Glu Gly Arg Gln His 
                245                 250                 255     


Pro Ile Gln Val Phe Tyr Thr Lys Gln Pro Gln Asn Asp Tyr Leu His 
            260                 265                 270         


Ala Ala Leu Val Ser Val Phe Gln Ile His Gln Glu Ala Pro Ser Ser 
        275                 280                 285             


Gln Asp Ile Leu Val Phe Leu Thr Gly Gln Glu Glu Ile Glu Ala Met 
    290                 295                 300                 


Ser Lys Thr Cys Arg Asp Ile Ala Lys His Leu Pro Asp Gly Cys Pro 
305                 310                 315                 320 


Ala Met Leu Val Leu Pro Leu Tyr Ala Ser Leu Pro Tyr Ala Gln Gln 
                325                 330                 335     


Leu Arg Val Phe Gln Gly Ala Pro Lys Gly Tyr Arg Lys Val Ile Ile 
            340                 345                 350         


Ser Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Thr Gly Ile Lys Tyr 
        355                 360                 365             


Val Val Asp Thr Gly Met Val Lys Ala Lys Lys Tyr Asn Pro Asp Ser 
    370                 375                 380                 


Gly Leu Glu Val Leu Ala Val Gln Arg Val Ser Lys Thr Gln Ala Trp 
385                 390                 395                 400 


Gln Arg Thr Gly Arg Ala Gly Arg Glu Asp Ser Gly Ile Cys Tyr Arg 
                405                 410                 415     


Leu Tyr Thr Glu Asp Glu Phe Glu Lys Phe Asp Lys Met Thr Val Pro 
            420                 425                 430         


Glu Ile Gln Arg Cys Asn Leu Ala Ser Val Met Leu Gln Leu Leu Ala 
        435                 440                 445             


Met Lys Val Pro Asn Val Leu Thr Phe Asp Phe Met Ser Lys Pro Ser 
    450                 455                 460                 


Pro Asp His Ile Gln Ala Ala Ile Ala Gln Leu Asp Leu Leu Gly Ala 
465                 470                 475                 480 


Leu Glu His Lys Asp Asp Gln Leu Thr Leu Thr Pro Met Gly Arg Lys 
                485                 490                 495     


Met Ala Ala Phe Pro Leu Glu Pro Lys Phe Ala Lys Thr Ile Leu Met 
            500                 505                 510         


Ser Pro Lys Phe His Cys Thr Glu Glu Ile Leu Thr Ile Val Ser Leu 
        515                 520                 525             


Leu Ser Val Asp Ser Val Leu His Asn Pro Pro Ser Arg Arg Glu Glu 
    530                 535                 540                 


Val Gln Gly Val Arg Lys Lys Phe Ile Ser Ser Glu Gly Asp His Met 
545                 550                 555                 560 


Thr Leu Leu Asn Ile Tyr Arg Thr Phe Lys Asn Leu Gly Gly Asn Lys 
                565                 570                 575     


Asp Trp Cys Lys Glu Asn Phe Val Asn Ser Lys Asn Met Thr Leu Val 
            580                 585                 590         


Ala Glu Val Arg Ala Gln Leu Arg Asp Ile Cys Leu Lys Met Ser Met 
        595                 600                 605             


Pro Ile Ala Ser Ser Arg Gly Asp Val Glu Ser Val Arg Arg Cys Leu 
    610                 615                 620                 


Ala His Ser Leu Phe Met Ser Thr Ala Glu Leu Gln Pro Asp Gly Thr 
625                 630                 635                 640 


Tyr Ala Thr Thr Asp Thr His Gln Pro Val Ala Ile His Pro Ser Ser 
                645                 650                 655     


Val Leu Phe His Cys Lys Pro Ala Cys Val Val Tyr Thr Glu Leu Leu 
            660                 665                 670         


Tyr Thr Asn Lys Cys Tyr Met Arg Asp Leu Cys Val Ile Asp Ala Gln 
        675                 680                 685             


Trp Leu Tyr Glu Ala Ala Pro Glu Tyr Phe Arg Arg Lys Leu Arg Thr 
    690                 695                 700                 


Ala Arg Asn 
705         


<210>  349
<211>  2211
<212>  DNA
<213>  Homo sapiens

<400>  349
atgggctcac cgctgaggtt cgacgggcgg gtggtactgg tcaccggcgc gggggcagga       60

ttgggccgag cctatgccct ggcttttgca gaaagaggag cgttagttgt tgtgaatgat      120

ttgggagggg acttcaaagg agttggtaaa ggctccttag ctgctgataa ggttgttgaa      180

gaaataagaa ggagaggtgg aaaagcagtg gccaactatg attcagtgga agaaggagag      240

aaggttgtga agacagccct ggatgctttt ggaagaatag atgttgtggt caacaatgct      300

ggaattctga gggatcgttc ctttgctagg ataagtgatg aagactggga tataatccac      360

agagttcatt tgcggggttc attccaagtg acacgggcag catgggaaca catgaagaaa      420

cagaagtatg gaaggattat tatgacttca tcagcttcag gaatatatgg caactttggc      480

caggccaatt atagtgctgc aaagttgggt cttctgggcc ttgcaaattc tcttgcaatt      540

gaaggcagga aaagcaacat tcattgtaac accattgctc ctaatgcggg atcacggatg      600

actcagacag ttatgcctga agatcttgtg gaagccctga agccagagta tgtggcacct      660

cttgtccttt ggctttgtca cgagagttgt gaggagaatg gtggcttgtt tgaggttgga      720

gcaggatgga ttggaaaatt acgctgggag cggactcttg gagctattgt aagacaaaag      780

aatcacccaa tgactcctga ggcagtcaag gctaactgga agaagatctg tgactttgag      840

aatgccagca agcctcagag tatccaagaa tcaactggca gtataattga agttctgagt      900

aaaatagatt cagaaggagg agtttcagca aatcatacta gtcgtgcaac gtctacagca      960

acatcaggat ttgctggagc tattggccag aaactccctc cattttctta tgcttatacg     1020

gaactggaag ctattatgta tgcccttgga gtgggagcgt caatcaagga tccaaaagat     1080

ttgaaattta tttatgaagg aagttctgat ttctcctgtt tgcccacctt cggagttatc     1140

ataggtcaga aatctatgat gggtggagga ttagcagaaa ttcctggact ttcaatcaac     1200

tttgcaaagg ttcttcatgg agagcagtac ttagagttat ataaaccact tcccagagca     1260

ggaaaattaa aatgtgaagc agttgttgct gatgtcctag ataaaggatc cggtgtagtg     1320

attattatgg atgtctattc ttattctgag aaggaactta tatgccacaa tcagttctct     1380

ctctttcttg ttggctctgg aggctttggt ggaaaacgga catcagacaa agtcaaggta     1440

gctgtagcca tacctaatag acctcctgat gctgtactta cagataccac ctctcttaat     1500

caggctgctt tgtaccgcct cagtggagac tggaatccct tacacattga tcctaacttt     1560

gctagtctag caggttttga caagcccata ttacatggat tatgtacatt tggattttct     1620

gccaggcgtg tgttacagca gtttgcagat aatgatgtgt caagattcaa ggcaattaag     1680

gctcgttttg caaaaccagt atatccagga caaactctac aaactgagat gtggaaggaa     1740

ggaaacagaa ttcattttca aaccaaggtc caagaaactg gagacattgt catttcaaat     1800

gcatatgtgg atcttgcacc aacatctggt acttcagcta agacaccctc tgagggcggg     1860

aagcttcaga gtacctttgt atttgaggaa ataggacgcc gcctaaagga tattgggcct     1920

gaggtggtga agaaagtaaa tgctgtattt gagtggcata taaccaaagg cggaaatatt     1980

ggggctaagt ggactattga cctgaaaagt ggttctggaa aagtgtacca aggccctgca     2040

aaaggtgctg ctgatacaac aatcatactt tcagatgaag atttcatgga ggtggtcctg     2100

ggcaagcttg accctcagaa ggcattcttt agtggcaggc tgaaggccag agggaacatc     2160

atgctgagcc agaaacttca gatgattctt aaagactacg ccaagctctg a              2211


<210>  350
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
1               5                   10                  15      


Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
            20                  25                  30          


Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
        35                  40                  45              


Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
    50                  55                  60                  


Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
65                  70                  75                  80  


Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                85                  90                  95      


Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
            100                 105                 110         


Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
        115                 120                 125             


Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
    130                 135                 140                 


Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
145                 150                 155                 160 


Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                165                 170                 175     


Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
            180                 185                 190         


Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
        195                 200                 205             


Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
    210                 215                 220                 


Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
225                 230                 235                 240 


Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                245                 250                 255     


Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
            260                 265                 270         


Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
        275                 280                 285             


Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
    290                 295                 300                 


Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
305                 310                 315                 320 


Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                325                 330                 335     


Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
            340                 345                 350         


Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
        355                 360                 365             


Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
    370                 375                 380                 


Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
385                 390                 395                 400 


Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                405                 410                 415     


Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
            420                 425                 430         


Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
        435                 440                 445             


Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
    450                 455                 460                 


Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
465                 470                 475                 480 


Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                485                 490                 495     


Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
            500                 505                 510         


Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
        515                 520                 525             


Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
    530                 535                 540                 


Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
545                 550                 555                 560 


Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                565                 570                 575     


Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
            580                 585                 590         


Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
        595                 600                 605             


Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
    610                 615                 620                 


Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
625                 630                 635                 640 


Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                645                 650                 655     


Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
            660                 665                 670         


Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
        675                 680                 685             


Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
    690                 695                 700                 


Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
705                 710                 715                 720 


Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                725                 730                 735     


<210>  351
<211>  1527
<212>  DNA
<213>  Homo sapiens

<400>  351
atgaatgaaa ataaagatac tgattcaaag aaaagtgaag aatacgaaga tgactttgaa       60

aaggacctgg agtggttaat taatgaaaat gaaaaaagtg atgccagcat aatagagatg      120

gcttgtgaga aggaagagaa tattaaccaa gacttaaaag agaatgagac agtaatggag      180

cacaccaaac ggcattctga tcctgacaaa tctttgcagg atgaggtctc accaagaaga      240

aatgacatca tttctgtacc aggtattcaa cctttggatc ccatatcaga ttcagatagt      300

gaaaactctt tccaggaatc caaactagaa agccagaaag acttggagga ggaagaggat      360

gaggaagtaa ggagatatat tatggagaaa attgtacaag ctaacaagct tctacagaat      420

caagaaccgg tgaatgataa aagggagcga aaacttaagt tcaaggacca gttagttgat      480

ttggaagttc ctccactaga agacactact acttttaaaa attattttga aaacgaaagg      540

aatatgtttg ggaaactgtc acaattatgt atttccaatg attttggaca agaagatgtg      600

ctcctgtcac ttactaatgg aagctgtgaa gaaaacaagg ataggacaat actggtagag      660

agagatggaa aatttgaact tctgaattta caagacattg ccagtcaggg gtttttgcct      720

cccattaata atgcaaatag tacagaaaat gaccctcagc agttgttacc cagatcttcc      780

aactcctctg tcagtggcac caagaaagaa gattctacag caaagattca tgctgtcact      840

cactcatcaa caggagagcc gctggcttat atcgctcagc caccactcaa ccgcaagact      900

tgtccaagct ctgctgtcaa ctcagatcga agtaaaggga atgggaaatc taatcacagg      960

acacagtctg cacatatctc accagtgact tcaacatact gtctttcccc tcgacagaaa     1020

gaactacaaa aacaactaga agaaaagaga gaaaaactga aaagagagga agagcgacga     1080

aaaatagaag aagagaaaga aaaaaagaga gagaatgaca tagtatttaa agcgtggttg     1140

caaaagaaaa gagagcaggt cttagaaatg aggagaattc agcgagcaaa ggaaattgaa     1200

gacatgaaca gtagagaaaa cagagatcca caacaagctt ttcgattatg gcttaaaaaa     1260

aagcacgaag agcagatgaa agaaagacag acagaagaac taagaaagca agaggaatgt     1320

ttattcttcc ttaaaggaac agaaggccgg gaaagggcct ttaaacaatg gttaagaagg     1380

aaacggatgg aaaaaatggc agagcaacaa gctgtcagag agagaactag acagctccga     1440

ctagaagcta agcgttctaa acagttacag caccacctat atatgtcaga agccaaacct     1500

tttcgtttta ctgatcatta taactga                                         1527


<210>  352
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Asn Glu Asn Lys Asp Thr Asp Ser Lys Lys Ser Glu Glu Tyr Glu 
1               5                   10                  15      


Asp Asp Phe Glu Lys Asp Leu Glu Trp Leu Ile Asn Glu Asn Glu Lys 
            20                  25                  30          


Ser Asp Ala Ser Ile Ile Glu Met Ala Cys Glu Lys Glu Glu Asn Ile 
        35                  40                  45              


Asn Gln Asp Leu Lys Glu Asn Glu Thr Val Met Glu His Thr Lys Arg 
    50                  55                  60                  


His Ser Asp Pro Asp Lys Ser Leu Gln Asp Glu Val Ser Pro Arg Arg 
65                  70                  75                  80  


Asn Asp Ile Ile Ser Val Pro Gly Ile Gln Pro Leu Asp Pro Ile Ser 
                85                  90                  95      


Asp Ser Asp Ser Glu Asn Ser Phe Gln Glu Ser Lys Leu Glu Ser Gln 
            100                 105                 110         


Lys Asp Leu Glu Glu Glu Glu Asp Glu Glu Val Arg Arg Tyr Ile Met 
        115                 120                 125             


Glu Lys Ile Val Gln Ala Asn Lys Leu Leu Gln Asn Gln Glu Pro Val 
    130                 135                 140                 


Asn Asp Lys Arg Glu Arg Lys Leu Lys Phe Lys Asp Gln Leu Val Asp 
145                 150                 155                 160 


Leu Glu Val Pro Pro Leu Glu Asp Thr Thr Thr Phe Lys Asn Tyr Phe 
                165                 170                 175     


Glu Asn Glu Arg Asn Met Phe Gly Lys Leu Ser Gln Leu Cys Ile Ser 
            180                 185                 190         


Asn Asp Phe Gly Gln Glu Asp Val Leu Leu Ser Leu Thr Asn Gly Ser 
        195                 200                 205             


Cys Glu Glu Asn Lys Asp Arg Thr Ile Leu Val Glu Arg Asp Gly Lys 
    210                 215                 220                 


Phe Glu Leu Leu Asn Leu Gln Asp Ile Ala Ser Gln Gly Phe Leu Pro 
225                 230                 235                 240 


Pro Ile Asn Asn Ala Asn Ser Thr Glu Asn Asp Pro Gln Gln Leu Leu 
                245                 250                 255     


Pro Arg Ser Ser Asn Ser Ser Val Ser Gly Thr Lys Lys Glu Asp Ser 
            260                 265                 270         


Thr Ala Lys Ile His Ala Val Thr His Ser Ser Thr Gly Glu Pro Leu 
        275                 280                 285             


Ala Tyr Ile Ala Gln Pro Pro Leu Asn Arg Lys Thr Cys Pro Ser Ser 
    290                 295                 300                 


Ala Val Asn Ser Asp Arg Ser Lys Gly Asn Gly Lys Ser Asn His Arg 
305                 310                 315                 320 


Thr Gln Ser Ala His Ile Ser Pro Val Thr Ser Thr Tyr Cys Leu Ser 
                325                 330                 335     


Pro Arg Gln Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys Arg Glu Lys 
            340                 345                 350         


Leu Lys Arg Glu Glu Glu Arg Arg Lys Ile Glu Glu Glu Lys Glu Lys 
        355                 360                 365             


Lys Arg Glu Asn Asp Ile Val Phe Lys Ala Trp Leu Gln Lys Lys Arg 
    370                 375                 380                 


Glu Gln Val Leu Glu Met Arg Arg Ile Gln Arg Ala Lys Glu Ile Glu 
385                 390                 395                 400 


Asp Met Asn Ser Arg Glu Asn Arg Asp Pro Gln Gln Ala Phe Arg Leu 
                405                 410                 415     


Trp Leu Lys Lys Lys His Glu Glu Gln Met Lys Glu Arg Gln Thr Glu 
            420                 425                 430         


Glu Leu Arg Lys Gln Glu Glu Cys Leu Phe Phe Leu Lys Gly Thr Glu 
        435                 440                 445             


Gly Arg Glu Arg Ala Phe Lys Gln Trp Leu Arg Arg Lys Arg Met Glu 
    450                 455                 460                 


Lys Met Ala Glu Gln Gln Ala Val Arg Glu Arg Thr Arg Gln Leu Arg 
465                 470                 475                 480 


Leu Glu Ala Lys Arg Ser Lys Gln Leu Gln His His Leu Tyr Met Ser 
                485                 490                 495     


Glu Ala Lys Pro Phe Arg Phe Thr Asp His Tyr Asn 
            500                 505             


<210>  353
<211>  3345
<212>  DNA
<213>  Homo sapiens

<400>  353
atgctgtctt gcttaaaaga agagatgcct ccccaggagc tcacccggcg actggccaca       60

gtgatcactc atgtcgatga aattatgcag caggaagtca gacccctgat ggcggtggag      120

ataatagaac aacttcacag acaatttgcc attctttcag gaggccgagg ggaggatggc      180

gcccccatca tcacgttccc agagttttcg gggttcaaac acatcccaga tgaagacttc      240

ctgaatgtca tgacctacct gactagcatc cccagtgtgg aggctgccag cattggattc      300

attgttgtta tcgacagacg aagagacaag tggagctccg taaaggcatc cttgacacga      360

atagctgtgg catttccagg aaacttacag ctcatattca tccttcgtcc atctcgcttt      420

atccagagga cattcactga cattggcatt aaatactatc gaaatgagtt taaaacgaaa      480

gtgccgatca tcatggtaaa ctctgtctct gaccttcacg gctacatcga caaaagccaa      540

ctgacccggg aattaggggg gactttggaa tatcgccacg gtcagtgggt aaatcaccgc      600

actgccatcg aaaactttgc cttgaccttg aagaccactg cccagatgct gcagacgttt      660

gggtcctgcc tggccacagc agagctgccc agaagcatgc tatccacgga agaccttctc      720

atgtcccaca caaggcagcg ggacaagctg caggatgagc tgaaattact tggaaagcag      780

gggaccacat tgctgtcatg catccaagaa ccagcaacca aatgtcccaa cagcaaactc      840

aatctcaacc aacttgagaa tgtaactacc atggaaaggt tattagttca actggatgaa      900

acagaaaaag cctttagtca cttttggtct gagcatcatc tgaagcttaa ccagtgccta      960

caactacagc attttgagca cgatttttgt aaggctaagc ttgccctgga taatttgctg     1020

gaagagcaag cagagtttac aggcattgga gacagcgtga tgcacgtgga gcagattctt     1080

aaggaacaca aaaaactgga ggaaaaaagc caggagcccc tggaaaaggc ccagctgctg     1140

gcactggttg gggaccagct catccaaagc caccattatg cagcagatgc catcaggccc     1200

cggtgtgtgg agctcaggca cctctgtgac gatttcatca atggaaacaa gaaaaaatgg     1260

gacattttag gaaagtcctt agagtttcat agacagctgg acaaggtcag ccaatggtgt     1320

gaggcaggaa tctacctctt ggcttcccaa gctgtagaca agtgccagtc tcgagaaggg     1380

gttgatatcg ccttgaacga cattgcgaca ttcctgggca cagtcaagga gtacccgttg     1440

ctcagcccca aggagtttta caacgagttt gagttgctgc tcaccctcga tgcaaaggcc     1500

aaagcccaga aagttttgca gaggctggat gatgtccagg aaatatttca caagaggcaa     1560

gtgagtctga tgaaactggc agccaaacag actcgtccag tgcaacctgt ggccccacat     1620

cctgagtctt caccaaaatg ggtgtcatca aaaaccagcc agccctccac ctcggtccct     1680

ctagctcgtc ctctgagaac gtctgaggaa ccttatacgg agacagagtt gaactcccgg     1740

ggaaaggaag atgatgagac taaatttgaa gtcaagagtg aagaaatctt tgaaagccat     1800

catgaaaggg ggaaccctga gctggagcag caggccaggc tcggagacct ttccccccgc     1860

aggcgcatta tacgtgactt gcttgagact gaagagattt acataaaaga gattaaaagc     1920

ataattgatg gatatatcac tccaatggat tttatttggc taaagcatct aattccagat     1980

gttcttcaga ataacaagga ctttctcttt gggaatatta gagaacttta cgaatttcac     2040

aacaggactt ttctaaaaga gttggaaaag tgtgctgaga accctgaact tctggcacat     2100

tgctttctca agagaaaaga agatcttcag atatatttta aataccataa gaatctgccc     2160

cgagctaggg caatctggca agagtgtcaa gactgcgcct actttggggt atgccagcgc     2220

caactggatc acaatctccc tctttttaag tatctcaaag gaccaagcca gagacttata     2280

aaataccaga tgctgttgaa gggtctgctg gatttcgagt ctcctgaaga tatggagata     2340

gacccaggtg aactaggagg ctcggctaag gatgggccaa agagaaccaa agattcagca     2400

ttctcaactg aactacaaca agctttggca gtgatagagg atttgatcaa gtcctgtgag     2460

ttggctgtgg acctagcagc agtgactgaa tgtccggacg atattggaaa actaggcaag     2520

ctgttgctgc acggcccttt cagcgtctgg acaattcaca aggatcgtta taaaatgaag     2580

gatttgattc gatttaaacc cagccagagg caaatctacc tatttgaaag gggaatagtg     2640

ttctgtaaga tacgaatgga gcctggggac cagggattat ctcctcatta cagcttcaag     2700

aagaccatga agctgatgac actttcaatt cgccagcttg gaagggggag ccatagaaag     2760

tttgagattg ccagtcgaaa tggacttgag aaatacatcc tgcaggcagc ttcaaaagaa     2820

atcagagact gttggttttc agaaataagt aaattattga tggaacaaca aaataatatc     2880

aaagaccaag gaaatccaca gtttgaaatg agcacgagca aaggcagtgg agcaggatcc     2940

ggaccatgga ttaaaaatat ggaaagagct accactagca aggaagaccc ggcctccagc     3000

acaggaggga ttaaaggctg ctccagcagg gagtttagct ccatggacac ctttgaagac     3060

tgtgaaggcg cagaagacat ggaaaaggag agcagtgctc tgagtctcgc gggccttttc     3120

cagtcggacg acagtcacga aacctgttcc tccaaatctg ctttcctgga gaggggagaa     3180

agcagccagg gagaaaaaga agaacgcgat gaggaggaaa cggcgacccg cagcaccgag     3240

gaggagcgcg ctggggcgtc cacgggccgg ctggctcctg cgggggcgac ggctggtttc     3300

caggcgaggg cgctgcgccc gaggacctcc gcccaggaga gctga                     3345


<210>  354
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Leu Ser Cys Leu Lys Glu Glu Met Pro Pro Gln Glu Leu Thr Arg 
1               5                   10                  15      


Arg Leu Ala Thr Val Ile Thr His Val Asp Glu Ile Met Gln Gln Glu 
            20                  25                  30          


Val Arg Pro Leu Met Ala Val Glu Ile Ile Glu Gln Leu His Arg Gln 
        35                  40                  45              


Phe Ala Ile Leu Ser Gly Gly Arg Gly Glu Asp Gly Ala Pro Ile Ile 
    50                  55                  60                  


Thr Phe Pro Glu Phe Ser Gly Phe Lys His Ile Pro Asp Glu Asp Phe 
65                  70                  75                  80  


Leu Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Val Glu Ala Ala 
                85                  90                  95      


Ser Ile Gly Phe Ile Val Val Ile Asp Arg Arg Arg Asp Lys Trp Ser 
            100                 105                 110         


Ser Val Lys Ala Ser Leu Thr Arg Ile Ala Val Ala Phe Pro Gly Asn 
        115                 120                 125             


Leu Gln Leu Ile Phe Ile Leu Arg Pro Ser Arg Phe Ile Gln Arg Thr 
    130                 135                 140                 


Phe Thr Asp Ile Gly Ile Lys Tyr Tyr Arg Asn Glu Phe Lys Thr Lys 
145                 150                 155                 160 


Val Pro Ile Ile Met Val Asn Ser Val Ser Asp Leu His Gly Tyr Ile 
                165                 170                 175     


Asp Lys Ser Gln Leu Thr Arg Glu Leu Gly Gly Thr Leu Glu Tyr Arg 
            180                 185                 190         


His Gly Gln Trp Val Asn His Arg Thr Ala Ile Glu Asn Phe Ala Leu 
        195                 200                 205             


Thr Leu Lys Thr Thr Ala Gln Met Leu Gln Thr Phe Gly Ser Cys Leu 
    210                 215                 220                 


Ala Thr Ala Glu Leu Pro Arg Ser Met Leu Ser Thr Glu Asp Leu Leu 
225                 230                 235                 240 


Met Ser His Thr Arg Gln Arg Asp Lys Leu Gln Asp Glu Leu Lys Leu 
                245                 250                 255     


Leu Gly Lys Gln Gly Thr Thr Leu Leu Ser Cys Ile Gln Glu Pro Ala 
            260                 265                 270         


Thr Lys Cys Pro Asn Ser Lys Leu Asn Leu Asn Gln Leu Glu Asn Val 
        275                 280                 285             


Thr Thr Met Glu Arg Leu Leu Val Gln Leu Asp Glu Thr Glu Lys Ala 
    290                 295                 300                 


Phe Ser His Phe Trp Ser Glu His His Leu Lys Leu Asn Gln Cys Leu 
305                 310                 315                 320 


Gln Leu Gln His Phe Glu His Asp Phe Cys Lys Ala Lys Leu Ala Leu 
                325                 330                 335     


Asp Asn Leu Leu Glu Glu Gln Ala Glu Phe Thr Gly Ile Gly Asp Ser 
            340                 345                 350         


Val Met His Val Glu Gln Ile Leu Lys Glu His Lys Lys Leu Glu Glu 
        355                 360                 365             


Lys Ser Gln Glu Pro Leu Glu Lys Ala Gln Leu Leu Ala Leu Val Gly 
    370                 375                 380                 


Asp Gln Leu Ile Gln Ser His His Tyr Ala Ala Asp Ala Ile Arg Pro 
385                 390                 395                 400 


Arg Cys Val Glu Leu Arg His Leu Cys Asp Asp Phe Ile Asn Gly Asn 
                405                 410                 415     


Lys Lys Lys Trp Asp Ile Leu Gly Lys Ser Leu Glu Phe His Arg Gln 
            420                 425                 430         


Leu Asp Lys Val Ser Gln Trp Cys Glu Ala Gly Ile Tyr Leu Leu Ala 
        435                 440                 445             


Ser Gln Ala Val Asp Lys Cys Gln Ser Arg Glu Gly Val Asp Ile Ala 
    450                 455                 460                 


Leu Asn Asp Ile Ala Thr Phe Leu Gly Thr Val Lys Glu Tyr Pro Leu 
465                 470                 475                 480 


Leu Ser Pro Lys Glu Phe Tyr Asn Glu Phe Glu Leu Leu Leu Thr Leu 
                485                 490                 495     


Asp Ala Lys Ala Lys Ala Gln Lys Val Leu Gln Arg Leu Asp Asp Val 
            500                 505                 510         


Gln Glu Ile Phe His Lys Arg Gln Val Ser Leu Met Lys Leu Ala Ala 
        515                 520                 525             


Lys Gln Thr Arg Pro Val Gln Pro Val Ala Pro His Pro Glu Ser Ser 
    530                 535                 540                 


Pro Lys Trp Val Ser Ser Lys Thr Ser Gln Pro Ser Thr Ser Val Pro 
545                 550                 555                 560 


Leu Ala Arg Pro Leu Arg Thr Ser Glu Glu Pro Tyr Thr Glu Thr Glu 
                565                 570                 575     


Leu Asn Ser Arg Gly Lys Glu Asp Asp Glu Thr Lys Phe Glu Val Lys 
            580                 585                 590         


Ser Glu Glu Ile Phe Glu Ser His His Glu Arg Gly Asn Pro Glu Leu 
        595                 600                 605             


Glu Gln Gln Ala Arg Leu Gly Asp Leu Ser Pro Arg Arg Arg Ile Ile 
    610                 615                 620                 


Arg Asp Leu Leu Glu Thr Glu Glu Ile Tyr Ile Lys Glu Ile Lys Ser 
625                 630                 635                 640 


Ile Ile Asp Gly Tyr Ile Thr Pro Met Asp Phe Ile Trp Leu Lys His 
                645                 650                 655     


Leu Ile Pro Asp Val Leu Gln Asn Asn Lys Asp Phe Leu Phe Gly Asn 
            660                 665                 670         


Ile Arg Glu Leu Tyr Glu Phe His Asn Arg Thr Phe Leu Lys Glu Leu 
        675                 680                 685             


Glu Lys Cys Ala Glu Asn Pro Glu Leu Leu Ala His Cys Phe Leu Lys 
    690                 695                 700                 


Arg Lys Glu Asp Leu Gln Ile Tyr Phe Lys Tyr His Lys Asn Leu Pro 
705                 710                 715                 720 


Arg Ala Arg Ala Ile Trp Gln Glu Cys Gln Asp Cys Ala Tyr Phe Gly 
                725                 730                 735     


Val Cys Gln Arg Gln Leu Asp His Asn Leu Pro Leu Phe Lys Tyr Leu 
            740                 745                 750         


Lys Gly Pro Ser Gln Arg Leu Ile Lys Tyr Gln Met Leu Leu Lys Gly 
        755                 760                 765             


Leu Leu Asp Phe Glu Ser Pro Glu Asp Met Glu Ile Asp Pro Gly Glu 
    770                 775                 780                 


Leu Gly Gly Ser Ala Lys Asp Gly Pro Lys Arg Thr Lys Asp Ser Ala 
785                 790                 795                 800 


Phe Ser Thr Glu Leu Gln Gln Ala Leu Ala Val Ile Glu Asp Leu Ile 
                805                 810                 815     


Lys Ser Cys Glu Leu Ala Val Asp Leu Ala Ala Val Thr Glu Cys Pro 
            820                 825                 830         


Asp Asp Ile Gly Lys Leu Gly Lys Leu Leu Leu His Gly Pro Phe Ser 
        835                 840                 845             


Val Trp Thr Ile His Lys Asp Arg Tyr Lys Met Lys Asp Leu Ile Arg 
    850                 855                 860                 


Phe Lys Pro Ser Gln Arg Gln Ile Tyr Leu Phe Glu Arg Gly Ile Val 
865                 870                 875                 880 


Phe Cys Lys Ile Arg Met Glu Pro Gly Asp Gln Gly Leu Ser Pro His 
                885                 890                 895     


Tyr Ser Phe Lys Lys Thr Met Lys Leu Met Thr Leu Ser Ile Arg Gln 
            900                 905                 910         


Leu Gly Arg Gly Ser His Arg Lys Phe Glu Ile Ala Ser Arg Asn Gly 
        915                 920                 925             


Leu Glu Lys Tyr Ile Leu Gln Ala Ala Ser Lys Glu Ile Arg Asp Cys 
    930                 935                 940                 


Trp Phe Ser Glu Ile Ser Lys Leu Leu Met Glu Gln Gln Asn Asn Ile 
945                 950                 955                 960 


Lys Asp Gln Gly Asn Pro Gln Phe Glu Met Ser Thr Ser Lys Gly Ser 
                965                 970                 975     


Gly Ala Gly Ser Gly Pro Trp Ile Lys Asn Met Glu Arg Ala Thr Thr 
            980                 985                 990         


Ser Lys Glu Asp Pro Ala Ser Ser  Thr Gly Gly Ile Lys  Gly Cys Ser 
        995                 1000                 1005             


Ser Arg  Glu Phe Ser Ser Met  Asp Thr Phe Glu Asp  Cys Glu Gly 
    1010                 1015                 1020             


Ala Glu  Asp Met Glu Lys Glu  Ser Ser Ala Leu Ser  Leu Ala Gly 
    1025                 1030                 1035             


Leu Phe  Gln Ser Asp Asp Ser  His Glu Thr Cys Ser  Ser Lys Ser 
    1040                 1045                 1050             


Ala Phe  Leu Glu Arg Gly Glu  Ser Ser Gln Gly Glu  Lys Glu Glu 
    1055                 1060                 1065             


Arg Asp  Glu Glu Glu Thr Ala  Thr Arg Ser Thr Glu  Glu Glu Arg 
    1070                 1075                 1080             


Ala Gly  Ala Ser Thr Gly Arg  Leu Ala Pro Ala Gly  Ala Thr Ala 
    1085                 1090                 1095             


Gly Phe  Gln Ala Arg Ala Leu  Arg Pro Arg Thr Ser  Ala Gln Glu 
    1100                 1105                 1110             


Ser 
    


<210>  355
<211>  3681
<212>  DNA
<213>  Homo sapiens

<400>  355
atgaatccgc ggcaggggta ttccctcagc ggatactaca cccatccatt tcaaggctat       60

gagcacagac agctcaggta ccagcagcct gggccaggat cttcccccag tagtttcctg      120

cttaagcaaa tagaatttct caaggggcag ctcccagaag caccggtgat tggaaagcag      180

acaccgtcac tgccaccttc cctcccagga ctccggccaa ggtttccagt actacttgcc      240

tccagtacca gaggcaggca agtggacatc aggggtgtcc ccaggggcgt gcatctcaga      300

agtcaggggc tccagagagg gttccagcat ccttcaccac gtggcaggag tctgccacag      360

agaggtgttg attgcctttc ctcacatttc caggaactga gtatctacca agatcaggaa      420

caaaggatct taaagttcct ggaagagctt ggggaaggga aggccaccac agcacatgat      480

ctgtctggga aacttgggac tccgaagaaa gaaatcaatc gagttttata ctccctggca      540

aagaagggca agctacagaa agaggcagga acaccccctt tgtggaaaat cgcggtctcc      600

actcaggctt ggaaccagca cagcggagtg gtaagaccag acggtcatag ccaaggagcc      660

ccaaactcag acccgagttt ggaaccggaa gacagaaact ccacatctgt ctcagaagat      720

cttcttgagc cttttattgc agtctcagct caggcttgga accagcacag cggagtggta      780

agaccagaca gtcatagcca aggatcccca aactcagacc caggtttgga acctgaagac      840

agcaactcca catctgcctt ggaagatcct cttgagtttt tagacatggc cgagatcaag      900

gagaaaatct gcgactatct cttcaatgtg tctgactcct ctgccctgaa tttggctaaa      960

aatattggcc ttaccaaggc ccgagatata aatgctgtgc taattgacat ggaaaggcag     1020

ggggatgtct atagacaagg gacaacccct cccatatggc atttgacaga caagaagcga     1080

gagaggatgc aaatcaagag aaatacgaac agtgttcctg aaaccgctcc agctgcaatc     1140

cctgagacca aaagaaacgc agagttcctc acctgtaata tacccacatc aaatgcctca     1200

aataacatgg taaccacaga aaaagtggag aatgggcagg aacctgtcat aaagttagaa     1260

aacaggcaag aggccagacc agaaccagca agactgaaac cacctgttca ttacaatggc     1320

ccctcaaaag cagggtatgt tgactttgaa aatggccagt gggccacaga tgacatccca     1380

gatgacttga atagtatccg cgcagcacca ggtgagtttc gagccatcat ggagatgccc     1440

tccttctaca gtcatggctt gccacggtgt tcaccctaca agaaactgac agagtgccag     1500

ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt tcgctagtca aacctgtgag     1560

ttcaacatga tagagcagag tggaccaccc catgaacctc gatttaaatt ccaggttgtc     1620

atcaatggcc gagagtttcc cccagctgaa gctggaagca agaaagtggc caagcaggat     1680

gcagctatga aagccatgac aattctgcta gaggaagcca aagccaagga cagtggaaaa     1740

tcagaagaat catcccacta ttccacagag aaagaatcag agaagactgc agagtcccag     1800

acccccaccc cttcagccac atccttcttt tctgggaaga gccccgtcac cacactgctt     1860

gagtgtatgc acaaattggg gaactcctgc gaattccgtc tcctgtccaa agaaggccct     1920

gcccatgaac ccaagttcca atactgtgtt gcagtgggag cccaaacttt ccccagtgtg     1980

agtgctccca gcaagaaagt ggcaaagcag atggccgcag aggaagccat gaaggccctg     2040

catggggagg cgaccaactc catggcttct gataaccagc ctgaaggtat gatctcagag     2100

tcacttgata acttggaatc catgatgccc aacaaggtca ggaagattgg cgagctcgtg     2160

agatacctga acaccaaccc tgtgggtggc cttttggagt acgcccgctc ccatggcttt     2220

gctgctgaat tcaagttggt cgaccagtcc ggacctcctc acgagcccaa gttcgtttac     2280

caagcaaaag ttgggggtcg ctggttccca gccgtctgcg cacacagcaa gaagcaaggc     2340

aagcaggaag cagcagatgc ggctctccgt gtcttgattg gggagaacga gaaggcagaa     2400

cgcatgggtt tcacagaggt aaccccagtg acaggggcca gtctcagaag aactatgctc     2460

ctcctctcaa ggtccccaga agcacagcca aagacactcc ctctcactgg cagcaccttc     2520

catgaccaga tagccatgct gagccaccgg tgcttcaaca ctctgactaa cagcttccag     2580

ccctccttgc tcggccgcaa gattctggcc gccatcatta tgaaaaaaga ctctgaggac     2640

atgggtgtcg tcgtcagctt gggaacaggg aatcgctgtg tgaaaggaga ttctctcagc     2700

ctaaaaggag aaactgtcaa tgactgccat gcagaaataa tctcccggag aggcttcatc     2760

aggtttctct acagtgagtt aatgaaatac aactcccaga ctgcgaagga tagtatattt     2820

gaacctgcta agggaggaga aaagctccaa ataaaaaaga ctgtgtcatt ccatctgtat     2880

atcagcactg ctccgtgtgg agatggcgcc ctctttgaca agtcctgcag cgaccgtgct     2940

atggaaagca cagaatcccg ccactaccct gtcttcgaga atcccaaaca aggaaagctc     3000

cgcaccaagg tggagaacgg agaaggcaca atccctgtgg aatccagtga cattgtgcct     3060

acgtgggatg gcattcggct cggggagaga ctccgtacca tgtcctgtag tgacaaaatc     3120

ctacgctgga acgtgctggg cctgcaaggg gcactgttga cccacttcct gcagcccatt     3180

tatctcaaat ctgtcacatt gggttacctt ttcagccaag ggcatctgac ccgtgctatt     3240

tgctgtcgtg tgacaagaga tgggagtgca tttgaggatg gactacgaca tccctttatt     3300

gtcaaccacc ccaaggttgg cagagtcagc atatatgatt ccaaaaggca atccgggaag     3360

actaaggaga caagcgtcaa ctggtgtctg gctgatggct atgacctgga gatcctggac     3420

ggtaccagag gcactgtgga tgggccacgg aatgaattgt cccgggtctc caaaaagaac     3480

atttttcttc tatttaagaa gctctgctcc ttccgttacc gcagggatct actgagactc     3540

tcctatggtg aggccaagaa agctgcccgt gactacgaga cggccaagaa ctacttcaaa     3600

aaaggcctga aggatatggg ctatgggaac tggattagca aaccccagga ggaaaagaac     3660

ttttatctct gcccagtata g                                               3681


<210>  356
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     


<210>  357
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  357
atgaccacct gcagccgcca gttcacctcc tccagctcca tgaagggctc ctgcggcatc       60

gggggcggca tcgggggcgg ctccagccgc atctcctccg tcctggccgg agggtcctgc      120

cgcgccccca gcacctacgg gggcggcctg tctgtctcat cctcccgctt ctcctctggg      180

ggagcctgcg ggctgggggg cggctatggc ggtggcttca gcagcagcag cagcagcttt      240

ggtagtggct ttgggggagg atatggtggt ggccttggtg ctggcttggg tggtggcttt      300

ggtggtggct ttgctggtgg tgatgggctt ctggtgggca gtgagaaggt gaccatgcag      360

aacctcaatg accgcctggc ctcctacctg gacaaggtgc gtgctctgga ggaggccaac      420

gccgacctgg aagtgaagat ccgtgactgg taccagaggc agcggcctgc tgagatcaaa      480

gactacagtc cctacttcaa gaccattgag gacctgagga acaagattct cacagccaca      540

gtggacaatg ccaatgtcct tctgcagatt gacaatgccc gtctggccgc ggatgacttc      600

cgcaccaagt atgagacaga gttgaacctg cgcatgagtg tggaagccga catcaatggc      660

ctgcgcaggg tgctggacga actgaccctg gccagagctg acctggagat gcagattgag      720

agcctgaagg aggagctggc ctacctgaag aagaaccacg aggaggagat gaatgccctg      780

agaggccagg tgggtggaga tgtcaatgtg gagatggacg ctgcacctgg cgtggacctg      840

agccgcattc tgaacgagat gcgtgaccag tatgagaaga tggcagagaa gaaccgcaag      900

gatgccgagg aatggttctt caccaagaca gaggagctga accgcgaggt ggccaccaac      960

agcgagctgg tgcagagcgg caagagcgag atctcggagc tccggcgcac catgcagaac     1020

ctggagattg agctgcagtc ccagctcagc atgaaagcat ccctggagaa cagcctggag     1080

gagaccaaag gtcgctactg catgcagctg gcccagatcc aggagatgat tggcagcgtg     1140

gaggagcagc tggcccagct ccgctgcgag atggagcagc agaaccagga gtacaagatc     1200

ctgctggacg tgaagacgcg gctggagcag gagatcgcca cctaccgccg cctgctggag     1260

ggcgaggacg cccacctctc ctcctcccag ttctcctctg gatcgcagtc atccagagat     1320

gtgacctcct ccagccgcca aatccgcacc aaggtcatgg atgtgcacga tggcaaggtg     1380

gtgtccaccc acgagcaggt ccttcgcacc aagaactga                            1419


<210>  358
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Cys Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210>  359
<211>  2022
<212>  DNA
<213>  Homo sapiens

<400>  359
atgatgtttc aggattcagt ggcctttgag gatgtggctg tgaccttcac ccaagaggag       60

tgggctttgc tggatccttc ccagaaaaat ctctgtagag atgtgatgca agaaaccttc      120

aggaacctgg cctctatagg gaaaaaatgg aaaccccaga acatatatgt agagtacgaa      180

aatctaagga gaaacctaag aattgtggga gagagactct ttgaaagtaa agaaggtcat      240

cagcatggag aaattttgac ccaggttcca gatgacatgc tgaagaaaac aactactgga      300

gtaaaatcat gcgaaagcag tgtgtatgga gaagtaggca gtgctcattc atctcttaat      360

aggcacatca gagatgacac tggacacaag gcatatgagt atcaagaata tggacagaaa      420

ccatataaat gtaaatactg taaaaaacct ttcaactgtc tctcctctgt tcagacacat      480

gaaagggctc atagtggaag gaaactctat gtttgtgagg aatgcggaaa aacatttatt      540

tcccattcaa accttcaaag acacaggata atgcaccgtg gagatggacc ttataagtgt      600

aaattttgtg ggaaagcctt gatgtttctc agtttgtatc ttatccacaa acgaactcac      660

actggagaga aaccatatca atgtaaacag tgtggtaaag cctttagtca ttctagtagc      720

cttcgaatac atgaaagaac tcacactggg gagaagcctt ataaatgtaa tgaatgtggg      780

aaagcattcc atagttccac atgccttcat gctcataaaa gaactcacac tggggagaag      840

ccatatgaat gtaaacagtg tgggaaagcc ttcagctctt cccattcctt tcaaatacat      900

gaaagaactc acacggggga gaagccatat gaatgtaagg aatgtggaaa agcattcaag      960

tgtcccagtt ctgttcgcag acatgaaaga acccactcta ggaaaaaacc ctatgaatgt     1020

aaacattgtg ggaaagtatt atcttatctt accagctttc aaaaccactt gggaatgcac     1080

actggagaga tatctcataa atgtaagata tgtgggaaag ccttttattc tcccagttca     1140

cttcaaacac atgaaaaaac tcacactgga gagaaaccct ataaatgcaa ccaatgtggt     1200

aaagccttta attcttccag ttccttccga tatcatgaaa gaactcacac tggagagaaa     1260

ccttacgagt gtaagcaatg tgggaaagcc ttcagatctg cctcactcct tcaaacacat     1320

ggtaggactc acacgggaga gaaaccctat gcatgtaagg aatgtggaaa accatttagt     1380

aatttctctt tctttcaaat acatgaaagg atgcacagag aagagaagcc gtatgaatgt     1440

aagggttatg ggaaaacatt cagtttgccc agtttatttc atagacatga aaggactcac     1500

actggaggaa aaacctatga atgcaagcag tgtggcagat ccttcaactg ttcgagctcc     1560

tttcgatatc atggaaggac tcacactgga gagaaaccct atgaatgcaa gcaatgtgga     1620

aaagccttca gatctgcctc acagcttcaa attcatggaa ggactcacac tggagagaaa     1680

ccttatgaat gtaagcagtg tgggaaagcc tttggatctg cctcacacct tcaaatgcat     1740

ggaaggactc acactggaga gaaaccctat gaatgtaagc agtgtgggaa gtcttttgga     1800

tgtgcctcgc gacttcaaat gcatggaagg actcacactg gagagaaacc gtataaatgt     1860

aagcaatgtg ggaaagcttt tggatgtccc tcaaaccttc gaaggcatgg aaggactcac     1920

actggagaga aaccctataa atgtaaccaa tgtggtaaag tctttagatg ttcttcacaa     1980

cttcaagtgc atggaagggc tcactgcata gacaccccat aa                        2022


<210>  360
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Met Phe Gln Asp Ser Val Ala Phe Glu Asp Val Ala Val Thr Phe 
1               5                   10                  15      


Thr Gln Glu Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Asn Leu Cys 
            20                  25                  30          


Arg Asp Val Met Gln Glu Thr Phe Arg Asn Leu Ala Ser Ile Gly Lys 
        35                  40                  45              


Lys Trp Lys Pro Gln Asn Ile Tyr Val Glu Tyr Glu Asn Leu Arg Arg 
    50                  55                  60                  


Asn Leu Arg Ile Val Gly Glu Arg Leu Phe Glu Ser Lys Glu Gly His 
65                  70                  75                  80  


Gln His Gly Glu Ile Leu Thr Gln Val Pro Asp Asp Met Leu Lys Lys 
                85                  90                  95      


Thr Thr Thr Gly Val Lys Ser Cys Glu Ser Ser Val Tyr Gly Glu Val 
            100                 105                 110         


Gly Ser Ala His Ser Ser Leu Asn Arg His Ile Arg Asp Asp Thr Gly 
        115                 120                 125             


His Lys Ala Tyr Glu Tyr Gln Glu Tyr Gly Gln Lys Pro Tyr Lys Cys 
    130                 135                 140                 


Lys Tyr Cys Lys Lys Pro Phe Asn Cys Leu Ser Ser Val Gln Thr His 
145                 150                 155                 160 


Glu Arg Ala His Ser Gly Arg Lys Leu Tyr Val Cys Glu Glu Cys Gly 
                165                 170                 175     


Lys Thr Phe Ile Ser His Ser Asn Leu Gln Arg His Arg Ile Met His 
            180                 185                 190         


Arg Gly Asp Gly Pro Tyr Lys Cys Lys Phe Cys Gly Lys Ala Leu Met 
        195                 200                 205             


Phe Leu Ser Leu Tyr Leu Ile His Lys Arg Thr His Thr Gly Glu Lys 
    210                 215                 220                 


Pro Tyr Gln Cys Lys Gln Cys Gly Lys Ala Phe Ser His Ser Ser Ser 
225                 230                 235                 240 


Leu Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
                245                 250                 255     


Asn Glu Cys Gly Lys Ala Phe His Ser Ser Thr Cys Leu His Ala His 
            260                 265                 270         


Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly 
        275                 280                 285             


Lys Ala Phe Ser Ser Ser His Ser Phe Gln Ile His Glu Arg Thr His 
    290                 295                 300                 


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Lys 
305                 310                 315                 320 


Cys Pro Ser Ser Val Arg Arg His Glu Arg Thr His Ser Arg Lys Lys 
                325                 330                 335     


Pro Tyr Glu Cys Lys His Cys Gly Lys Val Leu Ser Tyr Leu Thr Ser 
            340                 345                 350         


Phe Gln Asn His Leu Gly Met His Thr Gly Glu Ile Ser His Lys Cys 
        355                 360                 365             


Lys Ile Cys Gly Lys Ala Phe Tyr Ser Pro Ser Ser Leu Gln Thr His 
    370                 375                 380                 


Glu Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly 
385                 390                 395                 400 


Lys Ala Phe Asn Ser Ser Ser Ser Phe Arg Tyr His Glu Arg Thr His 
                405                 410                 415     


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Arg 
            420                 425                 430         


Ser Ala Ser Leu Leu Gln Thr His Gly Arg Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Ala Cys Lys Glu Cys Gly Lys Pro Phe Ser Asn Phe Ser Phe 
    450                 455                 460                 


Phe Gln Ile His Glu Arg Met His Arg Glu Glu Lys Pro Tyr Glu Cys 
465                 470                 475                 480 


Lys Gly Tyr Gly Lys Thr Phe Ser Leu Pro Ser Leu Phe His Arg His 
                485                 490                 495     


Glu Arg Thr His Thr Gly Gly Lys Thr Tyr Glu Cys Lys Gln Cys Gly 
            500                 505                 510         


Arg Ser Phe Asn Cys Ser Ser Ser Phe Arg Tyr His Gly Arg Thr His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Arg 
    530                 535                 540                 


Ser Ala Ser Gln Leu Gln Ile His Gly Arg Thr His Thr Gly Glu Lys 
545                 550                 555                 560 


Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Gly Ser Ala Ser His 
                565                 570                 575     


Leu Gln Met His Gly Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys 
            580                 585                 590         


Lys Gln Cys Gly Lys Ser Phe Gly Cys Ala Ser Arg Leu Gln Met His 
        595                 600                 605             


Gly Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly 
    610                 615                 620                 


Lys Ala Phe Gly Cys Pro Ser Asn Leu Arg Arg His Gly Arg Thr His 
625                 630                 635                 640 


Thr Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly Lys Val Phe Arg 
                645                 650                 655     


Cys Ser Ser Gln Leu Gln Val His Gly Arg Ala His Cys Ile Asp Thr 
            660                 665                 670         


Pro 
    


<210>  361
<211>  2221
<212>  DNA
<213>  Homo sapiens

<400>  361
gtacaaaaaa gcaggctcca ccatggcagt gggtgagccc ctggtgcaca tcagggtcac       60

tcttctgctg ctctggtttg ggatgttttt gtctatttct ggccactctc aggccaggcc      120

ctcccagtat ttcacttctc cagaagtggt gatccctttg aaggtgatca gcaggggcag      180

aggtgcaaag gctcctggat ggctctccta tagcctgcgg tttgggggac agagatacat      240

tgtccacatg agggtaaata agctgttgtt tgctgcacac cttcctgtgt tcacctacac      300

agagcagcat gccctgctcc aggatcagcc cttcatccag gatgactgct actaccatgg      360

ttatgtggag ggggtccctg agtccttggt tgcccttagt acctgttctg ggggctttct      420

tggaatgcta cagataaatg accttgttta tgaaatcaag ccaattagtg tttctgccac      480

atttgaacac ctagtatata agatagacag tgatgataca cagtttccac ctatgagatg      540

tgggttaaca gaagagaaaa tagcacacca gatggagttg caattgtcat ataatttcac      600

tctgaagcaa agttcttttg tgggctggtg gacccatcag cggtttgttg agctggtagt      660

ggtcgtggat aatattagat atcttttctc tcaaagtaat gcaacaacag tgcagcatga      720

agtatttaac gttgtcaata tagtggattc cttctatcat cctttggagg ttgatgtaat      780

tttgactgga attgatatat ggactgcatc aaatccactt cctaccagtg gagacctaga      840

taatgtttta gaggactttt ctatttggaa gaattataac cttaataatc gactacaaca      900

tgatgttgca catcttttca taaaagacac acaaggcatg aagcttggtg ttgcctatgt      960

taaaggaata tgccagaatc cttttaatac tggagttgat gtttttgaag acaacaggtt     1020

ggtcgttttt gcaattactt tgggccacga gcttggtcat aatttgggta tgcaacatga     1080

cacccagtgg tgtgtgtgcg agctacagtg gtgcataatg catgcctata gaaaggtgac     1140

aactaaattt agcaactgca gttatgccca atattgggac agtactatca gtagtggatt     1200

atgtattcaa ccgcctccat atccagggaa tatatttaga ctgaagtact gtgggaatct     1260

agtggttgaa gaaggggagg aatgtgactg tggaaccata cggcagtgtg caaaagatcc     1320

ctgttgtctg ttaaactgta ctctacatcc tggggctgct tgtgcttttg gaatatgttg     1380

caaagactgc aaatttctgc catcaggaac tttatgtaga caacaagttg gtgaatgtga     1440

ccttccagag tggtgcaatg ggacatccca tcaatgccca gatgatgtgt atgtgcagga     1500

cgggatctcc tgtaatgtga atgccttctg ctatgaaaag acgtgtaata accatgatat     1560

acaatgtaaa gagatttttg gccaagatgc aaggagtgca tctcagagtt gctaccaaga     1620

aatcaacacc caaggaaacc gtttcggtca ctgtggtatt gtaggcacaa catatgtaaa     1680

atgttggacc cctgatatca tgtgtgggag ggttcagtgt gaaaatgtgg gagtaattcc     1740

caatctgata gagcattcta cagtgcagca gtttcacctc aatgacacca cttgctgggg     1800

cactgattat catttaggga tggctatacc tgatattggt gaggtgaaag atggcacagt     1860

atgtggtcca gaaaagatct gcatccgtaa gaagtgtgcc agtatggttc atctgtcaca     1920

agcctgtcag cctaagacct gcaacatgag gggaatctgc aacaacaaac aacactgtca     1980

ctgcaaccat gaatgggcac ccccatactg caaggacaaa ggctatggag gtagtgctga     2040

tagtggccca cctcctaaga acaacatgga aggattaaat gtgatgggaa agttgcgtta     2100

cctgtcacta ttgtgccttc ttcctttggt tgctttttta ttattttgct tacatgtgct     2160

ttttaagaaa cgcacaaaaa gtaaagaaga tgaagaagga taggacccag ctttcttgta     2220

c                                                                     2221


<210>  362
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Ala Val Gly Glu Pro Leu Val His Ile Arg Val Thr Leu Leu Leu 
1               5                   10                  15      


Leu Trp Phe Gly Met Phe Leu Ser Ile Ser Gly His Ser Gln Ala Arg 
            20                  25                  30          


Pro Ser Gln Tyr Phe Thr Ser Pro Glu Val Val Ile Pro Leu Lys Val 
        35                  40                  45              


Ile Ser Arg Gly Arg Gly Ala Lys Ala Pro Gly Trp Leu Ser Tyr Ser 
    50                  55                  60                  


Leu Arg Phe Gly Gly Gln Arg Tyr Ile Val His Met Arg Val Asn Lys 
65                  70                  75                  80  


Leu Leu Phe Ala Ala His Leu Pro Val Phe Thr Tyr Thr Glu Gln His 
                85                  90                  95      


Ala Leu Leu Gln Asp Gln Pro Phe Ile Gln Asp Asp Cys Tyr Tyr His 
            100                 105                 110         


Gly Tyr Val Glu Gly Val Pro Glu Ser Leu Val Ala Leu Ser Thr Cys 
        115                 120                 125             


Ser Gly Gly Phe Leu Gly Met Leu Gln Ile Asn Asp Leu Val Tyr Glu 
    130                 135                 140                 


Ile Lys Pro Ile Ser Val Ser Ala Thr Phe Glu His Leu Val Tyr Lys 
145                 150                 155                 160 


Ile Asp Ser Asp Asp Thr Gln Phe Pro Pro Met Arg Cys Gly Leu Thr 
                165                 170                 175     


Glu Glu Lys Ile Ala His Gln Met Glu Leu Gln Leu Ser Tyr Asn Phe 
            180                 185                 190         


Thr Leu Lys Gln Ser Ser Phe Val Gly Trp Trp Thr His Gln Arg Phe 
        195                 200                 205             


Val Glu Leu Val Val Val Val Asp Asn Ile Arg Tyr Leu Phe Ser Gln 
    210                 215                 220                 


Ser Asn Ala Thr Thr Val Gln His Glu Val Phe Asn Val Val Asn Ile 
225                 230                 235                 240 


Val Asp Ser Phe Tyr His Pro Leu Glu Val Asp Val Ile Leu Thr Gly 
                245                 250                 255     


Ile Asp Ile Trp Thr Ala Ser Asn Pro Leu Pro Thr Ser Gly Asp Leu 
            260                 265                 270         


Asp Asn Val Leu Glu Asp Phe Ser Ile Trp Lys Asn Tyr Asn Leu Asn 
        275                 280                 285             


Asn Arg Leu Gln His Asp Val Ala His Leu Phe Ile Lys Asp Thr Gln 
    290                 295                 300                 


Gly Met Lys Leu Gly Val Ala Tyr Val Lys Gly Ile Cys Gln Asn Pro 
305                 310                 315                 320 


Phe Asn Thr Gly Val Asp Val Phe Glu Asp Asn Arg Leu Val Val Phe 
                325                 330                 335     


Ala Ile Thr Leu Gly His Glu Leu Gly His Asn Leu Gly Met Gln His 
            340                 345                 350         


Asp Thr Gln Trp Cys Val Cys Glu Leu Gln Trp Cys Ile Met His Ala 
        355                 360                 365             


Tyr Arg Lys Val Thr Thr Lys Phe Ser Asn Cys Ser Tyr Ala Gln Tyr 
    370                 375                 380                 


Trp Asp Ser Thr Ile Ser Ser Gly Leu Cys Ile Gln Pro Pro Pro Tyr 
385                 390                 395                 400 


Pro Gly Asn Ile Phe Arg Leu Lys Tyr Cys Gly Asn Leu Val Val Glu 
                405                 410                 415     


Glu Gly Glu Glu Cys Asp Cys Gly Thr Ile Arg Gln Cys Ala Lys Asp 
            420                 425                 430         


Pro Cys Cys Leu Leu Asn Cys Thr Leu His Pro Gly Ala Ala Cys Ala 
        435                 440                 445             


Phe Gly Ile Cys Cys Lys Asp Cys Lys Phe Leu Pro Ser Gly Thr Leu 
    450                 455                 460                 


Cys Arg Gln Gln Val Gly Glu Cys Asp Leu Pro Glu Trp Cys Asn Gly 
465                 470                 475                 480 


Thr Ser His Gln Cys Pro Asp Asp Val Tyr Val Gln Asp Gly Ile Ser 
                485                 490                 495     


Cys Asn Val Asn Ala Phe Cys Tyr Glu Lys Thr Cys Asn Asn His Asp 
            500                 505                 510         


Ile Gln Cys Lys Glu Ile Phe Gly Gln Asp Ala Arg Ser Ala Ser Gln 
        515                 520                 525             


Ser Cys Tyr Gln Glu Ile Asn Thr Gln Gly Asn Arg Phe Gly His Cys 
    530                 535                 540                 


Gly Ile Val Gly Thr Thr Tyr Val Lys Cys Trp Thr Pro Asp Ile Met 
545                 550                 555                 560 


Cys Gly Arg Val Gln Cys Glu Asn Val Gly Val Ile Pro Asn Leu Ile 
                565                 570                 575     


Glu His Ser Thr Val Gln Gln Phe His Leu Asn Asp Thr Thr Cys Trp 
            580                 585                 590         


Gly Thr Asp Tyr His Leu Gly Met Ala Ile Pro Asp Ile Gly Glu Val 
        595                 600                 605             


Lys Asp Gly Thr Val Cys Gly Pro Glu Lys Ile Cys Ile Arg Lys Lys 
    610                 615                 620                 


Cys Ala Ser Met Val His Leu Ser Gln Ala Cys Gln Pro Lys Thr Cys 
625                 630                 635                 640 


Asn Met Arg Gly Ile Cys Asn Asn Lys Gln His Cys His Cys Asn His 
                645                 650                 655     


Glu Trp Ala Pro Pro Tyr Cys Lys Asp Lys Gly Tyr Gly Gly Ser Ala 
            660                 665                 670         


Asp Ser Gly Pro Pro Pro Lys Asn Asn Met Glu Gly Leu Asn Val Met 
        675                 680                 685             


Gly Lys Leu Arg Tyr Leu Ser Leu Leu Cys Leu Leu Pro Leu Val Ala 
    690                 695                 700                 


Phe Leu Leu Phe Cys Leu His Val Leu Phe Lys Lys Arg Thr Lys Ser 
705                 710                 715                 720 


Lys Glu Asp Glu Glu Gly 
                725     


<210>  363
<211>  816
<212>  DNA
<213>  Homo sapiens

<400>  363
atggcctcta aagatgccca gaaccaaaga agaggtctgc ctggttttct tcctggagct       60

ccagacccag accaaagcct tcctgcctct tccaatccag ggaaccaagc atggcagctg      120

agtctccctc tgccaagcag tttcctgcca acagtcagtc tccctcctgg tctagaatat      180

ttaagccagt tagacctgat aattatacac cagcaggtgg agctgcttgg aatgatactt      240

ggtactgaga cctccaacaa atatgagatt aaaaacagct tgggacaaag aatttacttt      300

gcagtggagg aaagcatctg cttcaatcgt actttctgtt ccactctgcg atcttgcacc      360

ctgaggatca cagataactc aggtcgagag gtcattacag tgaacaggcc cttgagatgt      420

aacagctgct ggtgcccttg ctacctacaa gagttagaaa tccaagcccc tcctggtact      480

atagttggtt acgttacgca gaagtgggac ccctttctgc ctaaattcac aatccaaaat      540

gcaaacaaag aagatatttt gaaaattgtt ggtccttgtg tgacatgtgg ctgttttggc      600

gatgtggatt ttgaggtgaa aaccattaat gaaaagctta caattgggaa gatttcaaag      660

tactggtcag gatttgtaaa tgatgtcttc acaaatgctg acaatttcgg aattcatgtt      720

cctgcagatc tagatgtaac agtcaaagca gcaatgatcg gtgcctgttt tctctttgat      780

tttatgttct ttgaacattc actggctgga ttataa                                816


<210>  364
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Ala Ser Lys Asp Ala Gln Asn Gln Arg Arg Gly Leu Pro Gly Phe 
1               5                   10                  15      


Leu Pro Gly Ala Pro Asp Pro Asp Gln Ser Leu Pro Ala Ser Ser Asn 
            20                  25                  30          


Pro Gly Asn Gln Ala Trp Gln Leu Ser Leu Pro Leu Pro Ser Ser Phe 
        35                  40                  45              


Leu Pro Thr Val Ser Leu Pro Pro Gly Leu Glu Tyr Leu Ser Gln Leu 
    50                  55                  60                  


Asp Leu Ile Ile Ile His Gln Gln Val Glu Leu Leu Gly Met Ile Leu 
65                  70                  75                  80  


Gly Thr Glu Thr Ser Asn Lys Tyr Glu Ile Lys Asn Ser Leu Gly Gln 
                85                  90                  95      


Arg Ile Tyr Phe Ala Val Glu Glu Ser Ile Cys Phe Asn Arg Thr Phe 
            100                 105                 110         


Cys Ser Thr Leu Arg Ser Cys Thr Leu Arg Ile Thr Asp Asn Ser Gly 
        115                 120                 125             


Arg Glu Val Ile Thr Val Asn Arg Pro Leu Arg Cys Asn Ser Cys Trp 
    130                 135                 140                 


Cys Pro Cys Tyr Leu Gln Glu Leu Glu Ile Gln Ala Pro Pro Gly Thr 
145                 150                 155                 160 


Ile Val Gly Tyr Val Thr Gln Lys Trp Asp Pro Phe Leu Pro Lys Phe 
                165                 170                 175     


Thr Ile Gln Asn Ala Asn Lys Glu Asp Ile Leu Lys Ile Val Gly Pro 
            180                 185                 190         


Cys Val Thr Cys Gly Cys Phe Gly Asp Val Asp Phe Glu Val Lys Thr 
        195                 200                 205             


Ile Asn Glu Lys Leu Thr Ile Gly Lys Ile Ser Lys Tyr Trp Ser Gly 
    210                 215                 220                 


Phe Val Asn Asp Val Phe Thr Asn Ala Asp Asn Phe Gly Ile His Val 
225                 230                 235                 240 


Pro Ala Asp Leu Asp Val Thr Val Lys Ala Ala Met Ile Gly Ala Cys 
                245                 250                 255     


Phe Leu Phe Asp Phe Met Phe Phe Glu His Ser Leu Ala Gly Leu 
            260                 265                 270     


<210>  365
<211>  2649
<212>  DNA
<213>  Homo sapiens

<400>  365
atggagcctg cacccgcccg atctccgagg ccccagcagg accccgcccg gccccaggag       60

cccaccatgc ctccccccga gaccccctct gaaggccgcc agcccagccc cagccccagc      120

cctacagagc gagcccccgc ttcggaggag gagttccagt ttctgcgctg ccagcaatgc      180

caggcggaag ccaagtgccc gaagctgctg ccttgtctgc acacgctgtg ctcaggatgc      240

ctggaggcgt cgggcatgca gtgccccatc tgccaggcgc cctggcccct aggtgcagac      300

acacccgccc tggataacgt ctttttcgag agtctgcagc ggcgcctgtc ggtgtaccgg      360

cagattgtgg atgcgcaggc tgtgtgcacc cgctgcaaag agtcggccga cttctggtgc      420

tttgagtgcg agcagctcct ctgcgccaag tgcttcgagg cacaccagtg gttcctcaag      480

cacgaggccc ggcccctagc agagctgcgc aaccagtcgg tgcgtgagtt cctggacggc      540

acccgcaaga ccaacaacat cttctgctcc aaccccaacc accgcacccc tacgctgacc      600

agcatctact gccgaggatg ttccaagccg ctgtgctgct cgtgcgcgct ccttgacagc      660

agccacagtg agctcaagtg cgacatcagc gcagagatcc agcagcgaca ggaggagctg      720

gacgccatga cgcaggcgct gcaggagcag gatagtgcct ttggcgcggt tcacgcgcag      780

atgcacgcgg ccgtcggcca gctgggccgc gcgcgtgccg agaccgagga gctgatccgc      840

gagcgcgtgc gccaggtggt agctcacgtg cgggctcagg agcgcgagct gctggaggct      900

gtggacgcgc ggtaccagcg cgactacgag gagatggcca gtcggctggg ccgcctggat      960

gctgtgctgc agcgcatccg cacgggcagc gcgctggtgc agaggatgaa gtgctacgcc     1020

tcggaccagg aggtgctgga catgcacggt ttcctgcgcc aggcgctctg ccgcctgcgc     1080

caggaggagc cccagagcct gcaagctgcc gtgcgcaccg atggcttcga cgagttcaag     1140

gtgcgcctgc aggacctcag ctcttgcatc acccagggga aagatgcagc tgtatccaag     1200

aaagccagcc cagaggctgc cagcactccc agggacccta ttgacgttga cctgcccgag     1260

gaggcagaga gagtgaaggc ccaggttcag gccctggggc tggctgaagc ccagcctatg     1320

gctgtggtac agtcagtgcc cggggcacac cccgtgccag tgtacgcctt ctccatcaaa     1380

ggcccttcct atggagagga tgtctccaat acaacgacag cccagaagag gaagtgcagc     1440

cagacccagt gccccaggaa ggtcatcaag atggagtctg aggaggggaa ggaggcaagg     1500

ttggctcgga gctccccgga gcagcccagg cccagcacct ccaaggcagt ctcaccaccc     1560

cacctggatg gaccgcctag ccccaggagc cccgtcatag gaagtgaggt cttcctgccc     1620

aacagcaacc acgtggccag tggcgccggg gaggcagagg aacgcgttgt ggtgatcagc     1680

agctcggaag actcagatgc cgaaaactcg tcctcccgag agctggatga cagcagcagt     1740

gagtccagtg acctccagct ggaaggcccc agcaccctca gggtcctgga cgagaacctt     1800

gctgaccccc aagcagaaga cagacctctg gttttctttg acctcaagat tgacaatgaa     1860

acccagaaga ttagccagct ggctgcggtg aaccgggaaa gcaagttccg cgtggtcatc     1920

cagcctgaag ccttcttcag catctactcc aaggccgtgt ccctggaggt ggggctgcag     1980

cacttcctca gctttctgag ctccatgcgc cgccctatct tggcctgcta caagctgtgg     2040

gggcctggcc tcccaaactt cttccgggcc ctggaggaca ttaacaggct gtgggaattc     2100

caggaggcca tctcgggctt cctggctgcc ctgcctctca tccgggagcg tgtgcccggg     2160

gccagcagct tcaaactcaa gaacctggcc cagacctacc tggcgagaaa catgagcgag     2220

cgcagcgcca tggctgccgt gctggccatg cgtgacctgt gccgcctcct cgaggtctcc     2280

ccgggccccc agctggccca gcatgtctac cccttcagta gcctgcagtg ctttgcctcc     2340

ctgcagcccc tggtgcaggc agctgtgctg ccccgggctg aggcccgcct cctggcccta     2400

cacaacgtga gcttcatgga gctgctgagt gcacaccgcc gtgaccggca ggggggcctg     2460

aagaagtaca gccgctatct aagcctgcag accaccacgt tgccccctgc ccagcctgct     2520

ttcaacctgc aggctctggg cacctacttt gaaggcctgt tggagggtcc ggcgctggca     2580

cgggcagaag gagtctccac cccacttgct ggccgtggct tggcagagag ggcctcccag     2640

cagagctga                                                             2649


<210>  366
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Glu Pro Ala Pro Ala Arg Ser Pro Arg Pro Gln Gln Asp Pro Ala 
1               5                   10                  15      


Arg Pro Gln Glu Pro Thr Met Pro Pro Pro Glu Thr Pro Ser Glu Gly 
            20                  25                  30          


Arg Gln Pro Ser Pro Ser Pro Ser Pro Thr Glu Arg Ala Pro Ala Ser 
        35                  40                  45              


Glu Glu Glu Phe Gln Phe Leu Arg Cys Gln Gln Cys Gln Ala Glu Ala 
    50                  55                  60                  


Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr Leu Cys Ser Gly Cys 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Met Gln Cys Pro Ile Cys Gln Ala Pro Trp Pro 
                85                  90                  95      


Leu Gly Ala Asp Thr Pro Ala Leu Asp Asn Val Phe Phe Glu Ser Leu 
            100                 105                 110         


Gln Arg Arg Leu Ser Val Tyr Arg Gln Ile Val Asp Ala Gln Ala Val 
        115                 120                 125             


Cys Thr Arg Cys Lys Glu Ser Ala Asp Phe Trp Cys Phe Glu Cys Glu 
    130                 135                 140                 


Gln Leu Leu Cys Ala Lys Cys Phe Glu Ala His Gln Trp Phe Leu Lys 
145                 150                 155                 160 


His Glu Ala Arg Pro Leu Ala Glu Leu Arg Asn Gln Ser Val Arg Glu 
                165                 170                 175     


Phe Leu Asp Gly Thr Arg Lys Thr Asn Asn Ile Phe Cys Ser Asn Pro 
            180                 185                 190         


Asn His Arg Thr Pro Thr Leu Thr Ser Ile Tyr Cys Arg Gly Cys Ser 
        195                 200                 205             


Lys Pro Leu Cys Cys Ser Cys Ala Leu Leu Asp Ser Ser His Ser Glu 
    210                 215                 220                 


Leu Lys Cys Asp Ile Ser Ala Glu Ile Gln Gln Arg Gln Glu Glu Leu 
225                 230                 235                 240 


Asp Ala Met Thr Gln Ala Leu Gln Glu Gln Asp Ser Ala Phe Gly Ala 
                245                 250                 255     


Val His Ala Gln Met His Ala Ala Val Gly Gln Leu Gly Arg Ala Arg 
            260                 265                 270         


Ala Glu Thr Glu Glu Leu Ile Arg Glu Arg Val Arg Gln Val Val Ala 
        275                 280                 285             


His Val Arg Ala Gln Glu Arg Glu Leu Leu Glu Ala Val Asp Ala Arg 
    290                 295                 300                 


Tyr Gln Arg Asp Tyr Glu Glu Met Ala Ser Arg Leu Gly Arg Leu Asp 
305                 310                 315                 320 


Ala Val Leu Gln Arg Ile Arg Thr Gly Ser Ala Leu Val Gln Arg Met 
                325                 330                 335     


Lys Cys Tyr Ala Ser Asp Gln Glu Val Leu Asp Met His Gly Phe Leu 
            340                 345                 350         


Arg Gln Ala Leu Cys Arg Leu Arg Gln Glu Glu Pro Gln Ser Leu Gln 
        355                 360                 365             


Ala Ala Val Arg Thr Asp Gly Phe Asp Glu Phe Lys Val Arg Leu Gln 
    370                 375                 380                 


Asp Leu Ser Ser Cys Ile Thr Gln Gly Lys Asp Ala Ala Val Ser Lys 
385                 390                 395                 400 


Lys Ala Ser Pro Glu Ala Ala Ser Thr Pro Arg Asp Pro Ile Asp Val 
                405                 410                 415     


Asp Leu Pro Glu Glu Ala Glu Arg Val Lys Ala Gln Val Gln Ala Leu 
            420                 425                 430         


Gly Leu Ala Glu Ala Gln Pro Met Ala Val Val Gln Ser Val Pro Gly 
        435                 440                 445             


Ala His Pro Val Pro Val Tyr Ala Phe Ser Ile Lys Gly Pro Ser Tyr 
    450                 455                 460                 


Gly Glu Asp Val Ser Asn Thr Thr Thr Ala Gln Lys Arg Lys Cys Ser 
465                 470                 475                 480 


Gln Thr Gln Cys Pro Arg Lys Val Ile Lys Met Glu Ser Glu Glu Gly 
                485                 490                 495     


Lys Glu Ala Arg Leu Ala Arg Ser Ser Pro Glu Gln Pro Arg Pro Ser 
            500                 505                 510         


Thr Ser Lys Ala Val Ser Pro Pro His Leu Asp Gly Pro Pro Ser Pro 
        515                 520                 525             


Arg Ser Pro Val Ile Gly Ser Glu Val Phe Leu Pro Asn Ser Asn His 
    530                 535                 540                 


Val Ala Ser Gly Ala Gly Glu Ala Glu Glu Arg Val Val Val Ile Ser 
545                 550                 555                 560 


Ser Ser Glu Asp Ser Asp Ala Glu Asn Ser Ser Ser Arg Glu Leu Asp 
                565                 570                 575     


Asp Ser Ser Ser Glu Ser Ser Asp Leu Gln Leu Glu Gly Pro Ser Thr 
            580                 585                 590         


Leu Arg Val Leu Asp Glu Asn Leu Ala Asp Pro Gln Ala Glu Asp Arg 
        595                 600                 605             


Pro Leu Val Phe Phe Asp Leu Lys Ile Asp Asn Glu Thr Gln Lys Ile 
    610                 615                 620                 


Ser Gln Leu Ala Ala Val Asn Arg Glu Ser Lys Phe Arg Val Val Ile 
625                 630                 635                 640 


Gln Pro Glu Ala Phe Phe Ser Ile Tyr Ser Lys Ala Val Ser Leu Glu 
                645                 650                 655     


Val Gly Leu Gln His Phe Leu Ser Phe Leu Ser Ser Met Arg Arg Pro 
            660                 665                 670         


Ile Leu Ala Cys Tyr Lys Leu Trp Gly Pro Gly Leu Pro Asn Phe Phe 
        675                 680                 685             


Arg Ala Leu Glu Asp Ile Asn Arg Leu Trp Glu Phe Gln Glu Ala Ile 
    690                 695                 700                 


Ser Gly Phe Leu Ala Ala Leu Pro Leu Ile Arg Glu Arg Val Pro Gly 
705                 710                 715                 720 


Ala Ser Ser Phe Lys Leu Lys Asn Leu Ala Gln Thr Tyr Leu Ala Arg 
                725                 730                 735     


Asn Met Ser Glu Arg Ser Ala Met Ala Ala Val Leu Ala Met Arg Asp 
            740                 745                 750         


Leu Cys Arg Leu Leu Glu Val Ser Pro Gly Pro Gln Leu Ala Gln His 
        755                 760                 765             


Val Tyr Pro Phe Ser Ser Leu Gln Cys Phe Ala Ser Leu Gln Pro Leu 
    770                 775                 780                 


Val Gln Ala Ala Val Leu Pro Arg Ala Glu Ala Arg Leu Leu Ala Leu 
785                 790                 795                 800 


His Asn Val Ser Phe Met Glu Leu Leu Ser Ala His Arg Arg Asp Arg 
                805                 810                 815     


Gln Gly Gly Leu Lys Lys Tyr Ser Arg Tyr Leu Ser Leu Gln Thr Thr 
            820                 825                 830         


Thr Leu Pro Pro Ala Gln Pro Ala Phe Asn Leu Gln Ala Leu Gly Thr 
        835                 840                 845             


Tyr Phe Glu Gly Leu Leu Glu Gly Pro Ala Leu Ala Arg Ala Glu Gly 
    850                 855                 860                 


Val Ser Thr Pro Leu Ala Gly Arg Gly Leu Ala Glu Arg Ala Ser Gln 
865                 870                 875                 880 


Gln Ser 
        


<210>  367
<211>  1089
<212>  DNA
<213>  Homo sapiens

<400>  367
atgttaaaaa ataagggtca ctcatctaag aaagataact tggcagtcaa tgcagttgct       60

ttacaagatc acattttaca tgatcttcaa cttcgaaatc tttcagttgc agatcattct      120

aagacacaag tacaaaagaa agagaacaaa tctctaaaaa gagatacaaa ggcaataata      180

gatactggac ttaaaaaaac tacacagtgc cccaaactag aagactcaga aaaagaatat      240

gttcttgatc ccaaaccgcc gccgttgact ttggcacaga agttgggcct cattgggcct      300

ccaccacctc cactgtcatc agatgaatgg gagaaggtga aacagcgctc tctcctgcaa      360

ggggactccg tgcaaccatg ccccatctgt aaagaagaat tcgagcttcg tcctcaggtg      420

ctgctttcat gctcccatgt gttccacaaa gcatgtcttc aggcttttga aaagttcaca      480

aataagaaaa cctgtcctct ctgtagaaag aaccagtatc aaacccgagt gatacacgat      540

ggggcccgcc tgttcagaat caagtgtgtg accagaatcc aagcctactg gagaggatgt      600

gttgttagaa agtggtacag aaacctgagg aaaacagtac ctcccacaga tgccaagtta      660

agaaaaaaat tctttgaaaa aaagttcaca gaaatcagcc accgcatcct gtgctcatac      720

aacaccaaca ttgaagagct ctttgcagaa atcgatcagt gcttggccat aaatcgaagt      780

gttcttcagc agttggaaga aaaatgtggc catgagatca cagaagagga atgggagaaa      840

atccaagtgc aggctctgcg ccgggagacc cacgagtgct ccatctgcct ggcccctctc      900

tccgctgctg gcggtcagcg cgtgggtgca ggcaggcgtt ccagagagat ggccctcctg      960

tcctgctcac atgtgttcca ccatgcgtgt ctgctggcac tagaggagtt ctccgtggga     1020

gacaggcctc ctttccatgc ctgtcctctc tgccgctcct gctaccagaa gaagattctt     1080

gaatgttga                                                             1089


<210>  368
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210>  369
<211>  1293
<212>  DNA
<213>  Homo sapiens

<400>  369
atgtggcgcc tggtgccccc gaagctgggc cgcctgtccc gctcgctgaa gctggcggcg       60

ctgggcagcc tgttggtgct gatggtgctg cactcgccgt cgctgctcgc ctcttggcag      120

cgcaacgaac tgaccgaccg gcgcttcctg cagctcaata agtgcccggc gtgcttcggc      180

acgagctggt gccgccgctt cctcaacggg caggtggtat tcgaggcgtg gggccgcttg      240

cgcctgctgg acttcctcaa cgtgaagaac gtgtacttcg cgcagtacgg cgagccccgc      300

gagggcggcc gccgccgagt ggtgctcaag cgcctcggct cgcagcgcga gctggcgcag      360

ctcgaccaga gcatctgcaa gcgggccacc ggccggcccc gctgcgacct gctgcaggcc      420

atgccccgga ccgagttcgc gcgcctcaac ggcgacgtgc gtctgctcac gcccgaggcg      480

gtggagggct ggtcggacct ggtgcactgc ccctcgcagc gccttctcga ccgcctggtg      540

cgccgctacg cggagaccaa ggactcgggc agcttcctgc ttcgcaacct caaggactcg      600

gagcgcatgc agctgctgct gaccctggcc ttcaaccccg agccgctggt gctacagagt      660

tttccgtctg atgaaggttg gccatttgca aagtatcttg gagcttgtgg aagaatggtg      720

gctgtaaatt atgttggaga agaactgtgg agttacttta atgcgccatg ggaaaaacga      780

gttgacctcg cttggcaatt aatggaaata gcagaacagc ttacaaacaa tgactttgaa      840

tttgcactct acctcctgga cgtcagcttt gacaattttg cagttggtcc tagagatggg      900

aaggtaatca ttgtggatgc tgaaaatgtt ttggttgctg acaaaagatt aattagacaa      960

aataaacctg aaaattggga tgtatggtat gaaagcaagt ttgatgactg tgataaggag     1020

gcttgcttat cattttcaaa agaaattctt tgtgctcgtg ccactgtgga ccacaattac     1080

tatgctgttt gtcagaacct cttatccaga catgccacct ggcgtggcac ttctggagga     1140

ctccttcatg atccaccaag tgaaattgcc aaagatggcc ggctcgaggc cttgctggat     1200

gagtgtgcca acccaaagaa gcgctatggc agattccagg ctgcaaaaga actgcgtgaa     1260

tacctagcac aattaagtaa caacgtgagg tag                                  1293


<210>  370
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Trp Arg Leu Val Pro Pro Lys Leu Gly Arg Leu Ser Arg Ser Leu 
1               5                   10                  15      


Lys Leu Ala Ala Leu Gly Ser Leu Leu Val Leu Met Val Leu His Ser 
            20                  25                  30          


Pro Ser Leu Leu Ala Ser Trp Gln Arg Asn Glu Leu Thr Asp Arg Arg 
        35                  40                  45              


Phe Leu Gln Leu Asn Lys Cys Pro Ala Cys Phe Gly Thr Ser Trp Cys 
    50                  55                  60                  


Arg Arg Phe Leu Asn Gly Gln Val Val Phe Glu Ala Trp Gly Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Phe Leu Asn Val Lys Asn Val Tyr Phe Ala Gln Tyr 
                85                  90                  95      


Gly Glu Pro Arg Glu Gly Gly Arg Arg Arg Val Val Leu Lys Arg Leu 
            100                 105                 110         


Gly Ser Gln Arg Glu Leu Ala Gln Leu Asp Gln Ser Ile Cys Lys Arg 
        115                 120                 125             


Ala Thr Gly Arg Pro Arg Cys Asp Leu Leu Gln Ala Met Pro Arg Thr 
    130                 135                 140                 


Glu Phe Ala Arg Leu Asn Gly Asp Val Arg Leu Leu Thr Pro Glu Ala 
145                 150                 155                 160 


Val Glu Gly Trp Ser Asp Leu Val His Cys Pro Ser Gln Arg Leu Leu 
                165                 170                 175     


Asp Arg Leu Val Arg Arg Tyr Ala Glu Thr Lys Asp Ser Gly Ser Phe 
            180                 185                 190         


Leu Leu Arg Asn Leu Lys Asp Ser Glu Arg Met Gln Leu Leu Leu Thr 
        195                 200                 205             


Leu Ala Phe Asn Pro Glu Pro Leu Val Leu Gln Ser Phe Pro Ser Asp 
    210                 215                 220                 


Glu Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val 
225                 230                 235                 240 


Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro 
                245                 250                 255     


Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu 
            260                 265                 270         


Gln Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val 
        275                 280                 285             


Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile 
    290                 295                 300                 


Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln 
305                 310                 315                 320 


Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp 
                325                 330                 335     


Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala 
            340                 345                 350         


Arg Ala Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu 
        355                 360                 365             


Ser Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp 
    370                 375                 380                 


Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp 
385                 390                 395                 400 


Glu Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys 
                405                 410                 415     


Glu Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
            420                 425                 430 


<210>  371
<211>  9534
<212>  DNA
<213>  Homo sapiens

<400>  371
atgaggaaac atcggcactt gcccttagtg gccgtctttt gcctctttct ctcaggcttt       60

cctacaactc atgcccagca gcagcaagca gatgtcaaaa atggtgcggc tgctgatata      120

atatttctag tggattcctc ttggaccatt ggagaggaac atttccaact tgttcgagag      180

tttctatatg atgttgtaaa atccttagct gtgggagaaa atgatttcca ttttgctctg      240

gtccagttca acggaaaccc acataccgag ttcctgttaa atacgtatcg tactaaacaa      300

gaagtccttt ctcatatttc caacatgtct tatattgggg gaaccaatca gactggaaaa      360

ggattagaat acataatgca aagccacctc accaaggctg ctggaagccg ggccggtgac      420

ggagtccctc aggttatcgt agtgttaact gatggacact cgaaggatgg ccttgctctg      480

ccctcagcgg aacttaagtc tgctgatgtt aacgtgtttg caattggagt tgaggatgca      540

gatgaaggag cgttaaaaga aatagcaagt gaaccgctca atatgcatat gttcaaccta      600

gagaatttta cctcacttca tgacatagta ggaaacttag tgtcctgtgt gcattcatcc      660

gtgagtccag aaagggctgg ggacacggaa acccttaaag acatcacagc acaagactct      720

gctgacatta ttttccttat tgatggatca aacaacaccg gaagtgtcaa tttcgcagtc      780

attctcgact tccttgtaaa tctccttgag aaactcccaa ttggaactca gcagatccga      840

gtgggggtgg tccagtttag cgatgagccc agaaccatgt tctccttgga cacctactcc      900

accaaggccc aggttctggg tgcagtgaaa gccctcgggt ttgctggtgg ggagttggcc      960

aatatcggcc tcgcccttga tttcgtggtg gagaaccact tcacccgggc agggggcagc     1020

cgcgtggagg aaggggttcc ccaggtgctg gtcctcataa gtgccgggcc ttctagtgac     1080

gagattcgct acggggtggt agcactgaag caggctagcg tgttctcatt cggccttgga     1140

gcccaggccg cctccagggc agagcttcag cacatagcta ccgatgacaa cttggtgttt     1200

actgtcccgg aattccgtag ctttggggac ctccaggaga aattactgcc gtacattgtt     1260

ggcgtggccc aaaggcacat tgtcttgaaa ccgccaacca ttgtcacaca agtcattgaa     1320

gtcaacaaga gagacatagt cttcctggtg gatggctcat ctgcactggg actggccaac     1380

ttcaatgcca tccgagactt cattgctaaa gtcatccaga ggctggaaat cggacaggat     1440

cttatccagg tggcagtggc ccagtatgca gacactgtga ggcctgaatt ttatttcaat     1500

acccatccaa caaaaaggga agtcataacc gctgtgcgga aaatgaagcc cctggacggc     1560

tcggccctgt acacgggctc tgctctagac tttgttcgta acaacctatt cacgagttca     1620

gccggctacc gggctgccga ggggattcct aagcttttgg tgctgatcac aggtggtaag     1680

tccctagatg aaatcagcca gcctgcccag gagctgaaga gaagcagcat aatggccttt     1740

gccattggga acaagggtgc cgatcaggct gagctggaag agatcgcttt cgactcctcc     1800

ctggtgttca tcccagctga gttccgagcc gccccattgc aaggcatgct gcctggcttg     1860

ctggcacctc tcaggaccct ctctggaacc cctgaagttc actcaaacaa aagggatatc     1920

atctttcttt tggatggatc agccaacgtt ggaaaaacca atttccctta tgtgcgcgac     1980

tttgtaatga acctagttaa cagccttgat attggaaatg acaatattcg tgttggttta     2040

gtgcaattta gtgacactcc tgtaacggag ttctctttaa acacatacca gaccaagtca     2100

gatatccttg gtcatctgag gcagctgcag ctccagggag gttcgggcct gaacacaggc     2160

tcagccctaa gctatgtcta tgccaaccac ttcacggaag ctggcggcag caggatccgt     2220

gaacacgtgc cgcagctcct gcttctgctc acagctgggc agtctgagga ctcctatttg     2280

caagctgcca acgccttgac acgcgcgggc atcctgactt tttgtgtggg agctagccag     2340

gcgaataagg cagagcttga gcagattgct tttaacccaa gcctggtgta tctcatggat     2400

gatttcagct ccctgccagc tttgcctcag cagctgattc agcccctaac cacatatgtt     2460

agtggaggtg tggaggaagt accactcgct cagccagaga gcaagcgaga cattctgttc     2520

ctctttgacg gctcagccaa tcttgtgggc cagttccctg ttgtccgtga ctttctctac     2580

aagattatcg atgagctcaa tgtgaagcca gaggggaccc gaattgcggt ggctcagtac     2640

agcgatgatg tcaaggtgga gtcccgtttt gatgagcacc agagtaagcc tgagatcctg     2700

aatcttgtga agagaatgaa gatcaagacg ggcaaagccc tcaacctggg ctacgcgctg     2760

gactatgcac agaggtacat ttttgtgaag tctgctggca gccggatcga ggatggagtg     2820

cttcagttcc tggtgctgct ggtcgcagga aggtcatctg accgtgtgga tgggccagca     2880

agtaacctga agcagagtgg ggttgtgcct ttcatcttcc aagccaagaa cgcagaccct     2940

gctgagttag agcagatcgt gctgtctcca gcgtttatcc tggctgcaga gtcgcttccc     3000

aagattggag atcttcatcc acagatagtg aatctcttaa aatcagtgca caacggagca     3060

ccagcaccag tttcaggtga aaaggacgtg gtgtttctgc ttgatggctc tgagggcgtc     3120

aggagcggct tccctctgtt gaaagagttt gtccagagag tggtggaaag cctggatgtg     3180

ggccaggacc gggtccgcgt ggccgtggtg cagtacagcg accggaccag gcccgagttc     3240

tacctgaatt catacatgaa caagcaggac gtcgtcaacg ctgtccgcca gctgaccctg     3300

ctgggagggc cgacccccaa caccggggcc gccctggagt ttgtcctgag gaacatcctg     3360

gtcagctctg cgggaagcag gataacagaa ggtgtgcccc agctgctgat cgtcctcacg     3420

gccgacaggt ctggggatga tgtgcggaac ccctccgtgg tcgtgaagag gggtggggct     3480

gtgcccattg gcattggcat cgggaacgct gacatcacag agatgcagac catctccttc     3540

atcccggact ttgccgtggc cattcccacc tttcgccagc tggggaccgt ccaacaggtc     3600

atctctgaga gggtgaccca gctcacccgc gaggagctga gcaggctgca gccggtgttg     3660

cagcctctac cgagcccagg tgttggtggc aagagggacg tggtctttct catcgatggg     3720

tcccaaagtg ccgggcctga gttccagtac gttcgcaccc tcatagagag gctggttgac     3780

tacctggacg tgggctttga caccacccgg gtggctgtca tccagttcag cgatgacccc     3840

aaggtggagt tcctgctgaa cgcccattcc agcaaggatg aagtgcagaa cgcggtgcag     3900

cggctgaggc ccaagggagg gcggcagatc aacgtgggca atgccctgga gtacgtgtcc     3960

aggaacatct tcaagaggcc cctggggagc cgcattgaag agggcgtccc gcagttcctg     4020

gtcctcatct cgtctggaaa gtctgacgat gaggtggacg acccggcggt ggagctcaag     4080

cagtttggcg tggccccttt cacgatcgcc aggaacgcag accaggagga gctggtgaag     4140

atctcgctga gccccgaata tgtgttctcg gtgagcacct tccgggagct gcccagcctg     4200

gagcagaaac tgctgacgcc catcacgacc ctgacctcag agcagatcca gaagctctta     4260

gccagcactc gctatccacc tccagcagtt gagagtgatg ctgcagacat tgtctttctg     4320

atcgacagct ctgagggagt taggccagat ggctttgcac atattcgaga ttttgttagc     4380

aggattgttc gaagactcaa catcggcccc agtaaagtga gagttggggt cgtgcagttc     4440

agcaatgatg tcttcccaga attctatctg aaaacctaca gatcccaggc cccggtgctg     4500

gacgccatac ggcgcctgag gctcagaggg gggtccccac tgaacactgg caaggctctc     4560

gaatttgtgg caagaaacct ctttgttaag tctgcgggga gtcgcataga agacggggtg     4620

ccccaacacc tggtcctggt cctgggtgga aaatcccagg acgatgtgtc caggttcgcc     4680

caggtgatcc gttcctcggg cattgtgagt ttaggggtag gagaccggaa catcgacaga     4740

acagagctgc agaccatcac caatgacccc agactggtct tcacagtgcg agagttcaga     4800

gagcttccca acatagaaga aagaatcatg aactcgtttg gaccctccgc agccactcct     4860

gcacctccag gggtggacac ccctcctcct tcacggccag agaagaagaa agcagacatt     4920

gtgttcctgt tggatggttc catcaacttc aggagggaca gtttccagga agtgcttcgt     4980

tttgtgtctg aaatagtgga cacagtttat gaagatggcg actccatcca agtggggctt     5040

gtccagtaca actctgaccc cactgacgaa ttcttcctga aggacttctc taccaagagg     5100

cagattattg acgccatcaa caaagtggtc tacaaagggg gaagacacgc caacactaag     5160

gtgggccttg agcacctgcg ggtaaaccac tttgtgcctg aggcaggcag ccgcctggac     5220

cagcgggtcc ctcagattgc ctttgtgatc acgggaggaa agtcggtgga agatgcacag     5280

gatgtgagcc tggccctcac ccagaggggg gtcaaagtgt ttgctgttgg agtgaggaat     5340

atcgactcgg aggaggttgg aaagatagcg tccaacagcg ccacagcgtt ccgcgtgggc     5400

aacgtccagg agctgtccga actgagcgag caagttttgg aaactttgca tgatgcgatg     5460

catgaaaccc tttgccctgg tgtaactgat gctgccaaag cttgtaatct ggatgtgatt     5520

ctggggtttg atggttctag agaccagaat gtttttgtgg cccagaaggg cttcgagtcc     5580

aaggtggacg ccatcttgaa cagaatcagc cagatgcaca gggtcagctg cagcggtggc     5640

cgctcgccca ccgtgcgtgt gtcagtggtg gccaacacgc cctcgggccc ggtggaggcc     5700

tttgactttg acgagtacca gccagagatg ctcgagaagt tccggaacat gcgcagccag     5760

cacccctacg tcctcacgga ggacaccctg aaggtctacc tgaacaagtt cagacagtcc     5820

tcgccggaca gcgtgaaggt ggtcattcat tttactgatg gagcagacgg agatctggct     5880

gatttacaca gagcatctga gaacctccgc caagaaggag tccgtgcctt gatcctggtg     5940

ggccttgaac gagtggtcaa cttggagcgg ctaatgcatc tggagtttgg gcgagggttt     6000

atgtatgaca ggcccctgag gcttaacttg ctggacttgg attatgaact agcggagcag     6060

cttgacaaca ttgccgagaa agcttgctgt ggggttccct gcaagtgctc tgggcagagg     6120

ggagaccgcg ggcccatcgg cagcatcggg ccaaagggta ttcctggaga agacggctac     6180

cgaggctatc ctggtgatga gggtggaccc ggtgagcgtg gtccgcctgg tgtgaacggc     6240

actcaaggtt tccagggctg cccgggccag agaggagtaa agggctctcg gggattccca     6300

ggagagaagg gcgaagtagg agaaattgga ctggatggtc tggatggtga agatggagac     6360

aaaggattgc ctggttcttc tggagagaaa gggaatcctg gaagaagggg tgataaagga     6420

cctcgaggag agaaaggaga aagaggagat gttgggattc gaggggaccc gggtaaccca     6480

ggacaagaca gccaggagag aggacccaaa ggagaaaccg gtgacctcgg ccccatgggt     6540

gtcccaggga gagatggagt acctggagga cctggagaaa ctgggaagaa tggtggcttt     6600

ggccgaaggg gaccccccgg agctaagggc aacaagggcg gtcctggcca gccgggcttt     6660

gagggagagc aggggaccag aggtgcacag ggcccagctg gtcctgctgg tcctccaggg     6720

ctgataggag aacaaggcat ttctggacct cggggaagcg gaggtgccgc tggtgctcct     6780

ggagaacgag gcagaaccgg tccactggga agaaagggtg agcccggaga gccaggacca     6840

aaaggaggaa tcgggaaccg gggccctcgt ggggagacgg gagatgacgg gagagacgga     6900

gttggcagtg aaggacgcag aggcaaaaaa ggagaaagag gattccctgg atacccagga     6960

ccaaagggta acccaggtga acctgggcta aatggaacaa caggacccaa aggcatcaga     7020

ggccgaaggg gaaattcggg acctccaggg atagttggac agaagggaga ccctggctac     7080

ccaggaccag ctggtcccaa gggcaacagg ggcgactcca tcgatcaatg tgccctcatc     7140

caaagcatca aagataaatg cccttgctgt tacgggcccc tggagtgccc cgtcttccca     7200

acagaactag cctttgcttt agacacctct gagggagtca accaagacac tttcggccgg     7260

atgcgagatg tggtcttgag tattgtgaat gacctgacca ttgctgagag caactgccca     7320

cggggggccc gggtggctgt ggtcacctac aacaacgagg tgaccacgga gatccggttt     7380

gctgactcca agaggaagtc ggtcctcctg gacaagatta agaaccttca ggtggctctg     7440

acatccaaac agcagagtct ggagactgcc atgtcgtttg tggccaggaa cacatttaag     7500

cgtgtgagga acggattcct aatgaggaaa gtggctgttt tcttcagcaa cacacccaca     7560

agagcatccc cacagctcag agaggctgtg ctcaagctct cagatgcggg gatcaccccc     7620

ttgttcctta caaggcagga agaccggcag ctcatcaacg ctttgcagat caataacaca     7680

gcagtggggc atgcgcttgt cctgcctgca gggagagacc tcacagactt cctggagaat     7740

gtcctcacgt gtcatgtttg cttggacatc tgcaacatcg acccatcctg tggatttggc     7800

agttggaggc cttccttcag ggacaggaga gcggcaggga gcgatgtgga catcgacatg     7860

gctttcatct tagacagcgc tgagaccacc accctgttcc agttcaatga gatgaagaag     7920

tacatagcgt acctggtcag acaactggac atgagcccag atcccaaggc ctcccagcac     7980

ttcgccagag tggcagttgt gcagcacgcg ccctctgagt ccgtggacaa tgccagcatg     8040

ccacctgtga aggtggaatt ctccctgact gactatggct ccaaggagaa gctggtggac     8100

ttcctcagca ggggaatgac acagttgcag ggaaccaggg ccttaggcag tgccattgaa     8160

tacaccatag agaatgtctt tgaaagtgcc ccaaacccac gggacctgaa aattgtggtc     8220

ctgatgctga cgggcgaggt gccggagcag cagctggagg aggcccagag agtcatcctg     8280

caggccaaat gcaagggcta cttcttcgtg gtcctgggca ttggcaggaa ggtgaacatc     8340

aaggaggtat acaccttcgc cagtgagcca aacgacgtct tcttcaaatt agtggacaag     8400

tccaccgagc tcaacgagga gcctttgatg cgcttcggga ggctgttgcc atccttcgtc     8460

agcagtgaaa atgcttttta cttgtcccca gatatcagga aacagtgtga ttggttccaa     8520

ggggaccaac ccacaaagaa ccttgtgaag tttggtcaca aacaagtaaa tgttccgaat     8580

aacgttactt caagtcctac atccaaccca gtgacgacaa cgaagccggt gactacgacg     8640

aagccggtga ccaccacaac aaagcctgta accaccacaa caaagcctgt gactattata     8700

aatcagccat ctgtgaagcc agccgctgca aagccggccc ctgcgaaacc tgtggctgcc     8760

aagcctgtgg ccacaaagat ggccactgtt agacccccag tggcggtgaa gccagcaacg     8820

gcagcgaagc ctgtagcagc aaagccagca gctgtaagac cccccgctgc tgctgctgca     8880

aaaccagtgg cgaccaagcc tgaggtccct aggccacagg cagccaaacc agctgccacc     8940

aagccagcca ccactaagcc catggttaag atgtcccgtg aagtccaggt gtttgagata     9000

acagagaaca gcgccaaact ccactgggag agggctgagc cccccggtcc ttatttttat     9060

gacctcaccg tcacctcagc ccatgatcag tccctggttc tgaagcagaa cctcacggtc     9120

acggaccgcg tcattggagg cctgctcgct gggcagacat accatgtggc tgtggtctgc     9180

tacctgaggt ctcaggtcag agccacctac cacggaagtt tcagtacaaa gaaatctcag     9240

cccccacctc cacagccagc aaggtcagct tctagttcaa ccatcaatct aatggtgagc     9300

acagaaccat tggctctcac tgaaacagat atatgcaagt tgccgaaaga cgaaggaact     9360

tgcagggatt tcatattaaa atggtactat gatccaaaca ccaaaagctg tgcaagattc     9420

tggtatggag gttgtggtgg aaacgaaaac aaatttggat cacagaaaga atgtgaaaag     9480

gtttgcgctc ctgtgctcgc caaacccgga gtcatcagtg tgatgggaac ctaa           9534


<210>  372
<211>  3177
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile 
625                 630                 635                 640 


Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro 
                645                 650                 655     


Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly 
            660                 665                 670         


Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val 
        675                 680                 685             


Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly 
    690                 695                 700                 


His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly 
705                 710                 715                 720 


Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly 
                725                 730                 735     


Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala 
            740                 745                 750         


Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg 
        755                 760                 765             


Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala 
    770                 775                 780                 


Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp 
785                 790                 795                 800 


Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu 
                805                 810                 815     


Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro 
            820                 825                 830         


Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu 
        835                 840                 845             


Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp 
    850                 855                 860                 


Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr 
865                 870                 875                 880 


Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys 
                885                 890                 895     


Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys 
            900                 905                 910         


Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe 
        915                 920                 925             


Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu 
    930                 935                 940                 


Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala 
945                 950                 955                 960 


Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys 
                965                 970                 975     


Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe 
            980                 985                 990         


Ile Leu Ala Ala Glu Ser Leu Pro  Lys Ile Gly Asp Leu  His Pro Gln 
        995                 1000                 1005             


Ile Val  Asn Leu Leu Lys Ser  Val His Asn Gly Ala  Pro Ala Pro 
    1010                 1015                 1020             


Val Ser  Gly Glu Lys Asp Val  Val Phe Leu Leu Asp  Gly Ser Glu 
    1025                 1030                 1035             


Gly Val  Arg Ser Gly Phe Pro  Leu Leu Lys Glu Phe  Val Gln Arg 
    1040                 1045                 1050             


Val Val  Glu Ser Leu Asp Val  Gly Gln Asp Arg Val  Arg Val Ala 
    1055                 1060                 1065             


Val Val  Gln Tyr Ser Asp Arg  Thr Arg Pro Glu Phe  Tyr Leu Asn 
    1070                 1075                 1080             


Ser Tyr  Met Asn Lys Gln Asp  Val Val Asn Ala Val  Arg Gln Leu 
    1085                 1090                 1095             


Thr Leu  Leu Gly Gly Pro Thr  Pro Asn Thr Gly Ala  Ala Leu Glu 
    1100                 1105                 1110             


Phe Val  Leu Arg Asn Ile Leu  Val Ser Ser Ala Gly  Ser Arg Ile 
    1115                 1120                 1125             


Thr Glu  Gly Val Pro Gln Leu  Leu Ile Val Leu Thr  Ala Asp Arg 
    1130                 1135                 1140             


Ser Gly  Asp Asp Val Arg Asn  Pro Ser Val Val Val  Lys Arg Gly 
    1145                 1150                 1155             


Gly Ala  Val Pro Ile Gly Ile  Gly Ile Gly Asn Ala  Asp Ile Thr 
    1160                 1165                 1170             


Glu Met  Gln Thr Ile Ser Phe  Ile Pro Asp Phe Ala  Val Ala Ile 
    1175                 1180                 1185             


Pro Thr  Phe Arg Gln Leu Gly  Thr Val Gln Gln Val  Ile Ser Glu 
    1190                 1195                 1200             


Arg Val  Thr Gln Leu Thr Arg  Glu Glu Leu Ser Arg  Leu Gln Pro 
    1205                 1210                 1215             


Val Leu  Gln Pro Leu Pro Ser  Pro Gly Val Gly Gly  Lys Arg Asp 
    1220                 1225                 1230             


Val Val  Phe Leu Ile Asp Gly  Ser Gln Ser Ala Gly  Pro Glu Phe 
    1235                 1240                 1245             


Gln Tyr  Val Arg Thr Leu Ile  Glu Arg Leu Val Asp  Tyr Leu Asp 
    1250                 1255                 1260             


Val Gly  Phe Asp Thr Thr Arg  Val Ala Val Ile Gln  Phe Ser Asp 
    1265                 1270                 1275             


Asp Pro  Lys Val Glu Phe Leu  Leu Asn Ala His Ser  Ser Lys Asp 
    1280                 1285                 1290             


Glu Val  Gln Asn Ala Val Gln  Arg Leu Arg Pro Lys  Gly Gly Arg 
    1295                 1300                 1305             


Gln Ile  Asn Val Gly Asn Ala  Leu Glu Tyr Val Ser  Arg Asn Ile 
    1310                 1315                 1320             


Phe Lys  Arg Pro Leu Gly Ser  Arg Ile Glu Glu Gly  Val Pro Gln 
    1325                 1330                 1335             


Phe Leu  Val Leu Ile Ser Ser  Gly Lys Ser Asp Asp  Glu Val Asp 
    1340                 1345                 1350             


Asp Pro  Ala Val Glu Leu Lys  Gln Phe Gly Val Ala  Pro Phe Thr 
    1355                 1360                 1365             


Ile Ala  Arg Asn Ala Asp Gln  Glu Glu Leu Val Lys  Ile Ser Leu 
    1370                 1375                 1380             


Ser Pro  Glu Tyr Val Phe Ser  Val Ser Thr Phe Arg  Glu Leu Pro 
    1385                 1390                 1395             


Ser Leu  Glu Gln Lys Leu Leu  Thr Pro Ile Thr Thr  Leu Thr Ser 
    1400                 1405                 1410             


Glu Gln  Ile Gln Lys Leu Leu  Ala Ser Thr Arg Tyr  Pro Pro Pro 
    1415                 1420                 1425             


Ala Val  Glu Ser Asp Ala Ala  Asp Ile Val Phe Leu  Ile Asp Ser 
    1430                 1435                 1440             


Ser Glu  Gly Val Arg Pro Asp  Gly Phe Ala His Ile  Arg Asp Phe 
    1445                 1450                 1455             


Val Ser  Arg Ile Val Arg Arg  Leu Asn Ile Gly Pro  Ser Lys Val 
    1460                 1465                 1470             


Arg Val  Gly Val Val Gln Phe  Ser Asn Asp Val Phe  Pro Glu Phe 
    1475                 1480                 1485             


Tyr Leu  Lys Thr Tyr Arg Ser  Gln Ala Pro Val Leu  Asp Ala Ile 
    1490                 1495                 1500             


Arg Arg  Leu Arg Leu Arg Gly  Gly Ser Pro Leu Asn  Thr Gly Lys 
    1505                 1510                 1515             


Ala Leu  Glu Phe Val Ala Arg  Asn Leu Phe Val Lys  Ser Ala Gly 
    1520                 1525                 1530             


Ser Arg  Ile Glu Asp Gly Val  Pro Gln His Leu Val  Leu Val Leu 
    1535                 1540                 1545             


Gly Gly  Lys Ser Gln Asp Asp  Val Ser Arg Phe Ala  Gln Val Ile 
    1550                 1555                 1560             


Arg Ser  Ser Gly Ile Val Ser  Leu Gly Val Gly Asp  Arg Asn Ile 
    1565                 1570                 1575             


Asp Arg  Thr Glu Leu Gln Thr  Ile Thr Asn Asp Pro  Arg Leu Val 
    1580                 1585                 1590             


Phe Thr  Val Arg Glu Phe Arg  Glu Leu Pro Asn Ile  Glu Glu Arg 
    1595                 1600                 1605             


Ile Met  Asn Ser Phe Gly Pro  Ser Ala Ala Thr Pro  Ala Pro Pro 
    1610                 1615                 1620             


Gly Val  Asp Thr Pro Pro Pro  Ser Arg Pro Glu Lys  Lys Lys Ala 
    1625                 1630                 1635             


Asp Ile  Val Phe Leu Leu Asp  Gly Ser Ile Asn Phe  Arg Arg Asp 
    1640                 1645                 1650             


Ser Phe  Gln Glu Val Leu Arg  Phe Val Ser Glu Ile  Val Asp Thr 
    1655                 1660                 1665             


Val Tyr  Glu Asp Gly Asp Ser  Ile Gln Val Gly Leu  Val Gln Tyr 
    1670                 1675                 1680             


Asn Ser  Asp Pro Thr Asp Glu  Phe Phe Leu Lys Asp  Phe Ser Thr 
    1685                 1690                 1695             


Lys Arg  Gln Ile Ile Asp Ala  Ile Asn Lys Val Val  Tyr Lys Gly 
    1700                 1705                 1710             


Gly Arg  His Ala Asn Thr Lys  Val Gly Leu Glu His  Leu Arg Val 
    1715                 1720                 1725             


Asn His  Phe Val Pro Glu Ala  Gly Ser Arg Leu Asp  Gln Arg Val 
    1730                 1735                 1740             


Pro Gln  Ile Ala Phe Val Ile  Thr Gly Gly Lys Ser  Val Glu Asp 
    1745                 1750                 1755             


Ala Gln  Asp Val Ser Leu Ala  Leu Thr Gln Arg Gly  Val Lys Val 
    1760                 1765                 1770             


Phe Ala  Val Gly Val Arg Asn  Ile Asp Ser Glu Glu  Val Gly Lys 
    1775                 1780                 1785             


Ile Ala  Ser Asn Ser Ala Thr  Ala Phe Arg Val Gly  Asn Val Gln 
    1790                 1795                 1800             


Glu Leu  Ser Glu Leu Ser Glu  Gln Val Leu Glu Thr  Leu His Asp 
    1805                 1810                 1815             


Ala Met  His Glu Thr Leu Cys  Pro Gly Val Thr Asp  Ala Ala Lys 
    1820                 1825                 1830             


Ala Cys  Asn Leu Asp Val Ile  Leu Gly Phe Asp Gly  Ser Arg Asp 
    1835                 1840                 1845             


Gln Asn  Val Phe Val Ala Gln  Lys Gly Phe Glu Ser  Lys Val Asp 
    1850                 1855                 1860             


Ala Ile  Leu Asn Arg Ile Ser  Gln Met His Arg Val  Ser Cys Ser 
    1865                 1870                 1875             


Gly Gly  Arg Ser Pro Thr Val  Arg Val Ser Val Val  Ala Asn Thr 
    1880                 1885                 1890             


Pro Ser  Gly Pro Val Glu Ala  Phe Asp Phe Asp Glu  Tyr Gln Pro 
    1895                 1900                 1905             


Glu Met  Leu Glu Lys Phe Arg  Asn Met Arg Ser Gln  His Pro Tyr 
    1910                 1915                 1920             


Val Leu  Thr Glu Asp Thr Leu  Lys Val Tyr Leu Asn  Lys Phe Arg 
    1925                 1930                 1935             


Gln Ser  Ser Pro Asp Ser Val  Lys Val Val Ile His  Phe Thr Asp 
    1940                 1945                 1950             


Gly Ala  Asp Gly Asp Leu Ala  Asp Leu His Arg Ala  Ser Glu Asn 
    1955                 1960                 1965             


Leu Arg  Gln Glu Gly Val Arg  Ala Leu Ile Leu Val  Gly Leu Glu 
    1970                 1975                 1980             


Arg Val  Val Asn Leu Glu Arg  Leu Met His Leu Glu  Phe Gly Arg 
    1985                 1990                 1995             


Gly Phe  Met Tyr Asp Arg Pro  Leu Arg Leu Asn Leu  Leu Asp Leu 
    2000                 2005                 2010             


Asp Tyr  Glu Leu Ala Glu Gln  Leu Asp Asn Ile Ala  Glu Lys Ala 
    2015                 2020                 2025             


Cys Cys  Gly Val Pro Cys Lys  Cys Ser Gly Gln Arg  Gly Asp Arg 
    2030                 2035                 2040             


Gly Pro  Ile Gly Ser Ile Gly  Pro Lys Gly Ile Pro  Gly Glu Asp 
    2045                 2050                 2055             


Gly Tyr  Arg Gly Tyr Pro Gly  Asp Glu Gly Gly Pro  Gly Glu Arg 
    2060                 2065                 2070             


Gly Pro  Pro Gly Val Asn Gly  Thr Gln Gly Phe Gln  Gly Cys Pro 
    2075                 2080                 2085             


Gly Gln  Arg Gly Val Lys Gly  Ser Arg Gly Phe Pro  Gly Glu Lys 
    2090                 2095                 2100             


Gly Glu  Val Gly Glu Ile Gly  Leu Asp Gly Leu Asp  Gly Glu Asp 
    2105                 2110                 2115             


Gly Asp  Lys Gly Leu Pro Gly  Ser Ser Gly Glu Lys  Gly Asn Pro 
    2120                 2125                 2130             


Gly Arg  Arg Gly Asp Lys Gly  Pro Arg Gly Glu Lys  Gly Glu Arg 
    2135                 2140                 2145             


Gly Asp  Val Gly Ile Arg Gly  Asp Pro Gly Asn Pro  Gly Gln Asp 
    2150                 2155                 2160             


Ser Gln  Glu Arg Gly Pro Lys  Gly Glu Thr Gly Asp  Leu Gly Pro 
    2165                 2170                 2175             


Met Gly  Val Pro Gly Arg Asp  Gly Val Pro Gly Gly  Pro Gly Glu 
    2180                 2185                 2190             


Thr Gly  Lys Asn Gly Gly Phe  Gly Arg Arg Gly Pro  Pro Gly Ala 
    2195                 2200                 2205             


Lys Gly  Asn Lys Gly Gly Pro  Gly Gln Pro Gly Phe  Glu Gly Glu 
    2210                 2215                 2220             


Gln Gly  Thr Arg Gly Ala Gln  Gly Pro Ala Gly Pro  Ala Gly Pro 
    2225                 2230                 2235             


Pro Gly  Leu Ile Gly Glu Gln  Gly Ile Ser Gly Pro  Arg Gly Ser 
    2240                 2245                 2250             


Gly Gly  Ala Ala Gly Ala Pro  Gly Glu Arg Gly Arg  Thr Gly Pro 
    2255                 2260                 2265             


Leu Gly  Arg Lys Gly Glu Pro  Gly Glu Pro Gly Pro  Lys Gly Gly 
    2270                 2275                 2280             


Ile Gly  Asn Arg Gly Pro Arg  Gly Glu Thr Gly Asp  Asp Gly Arg 
    2285                 2290                 2295             


Asp Gly  Val Gly Ser Glu Gly  Arg Arg Gly Lys Lys  Gly Glu Arg 
    2300                 2305                 2310             


Gly Phe  Pro Gly Tyr Pro Gly  Pro Lys Gly Asn Pro  Gly Glu Pro 
    2315                 2320                 2325             


Gly Leu  Asn Gly Thr Thr Gly  Pro Lys Gly Ile Arg  Gly Arg Arg 
    2330                 2335                 2340             


Gly Asn  Ser Gly Pro Pro Gly  Ile Val Gly Gln Lys  Gly Asp Pro 
    2345                 2350                 2355             


Gly Tyr  Pro Gly Pro Ala Gly  Pro Lys Gly Asn Arg  Gly Asp Ser 
    2360                 2365                 2370             


Ile Asp  Gln Cys Ala Leu Ile  Gln Ser Ile Lys Asp  Lys Cys Pro 
    2375                 2380                 2385             


Cys Cys  Tyr Gly Pro Leu Glu  Cys Pro Val Phe Pro  Thr Glu Leu 
    2390                 2395                 2400             


Ala Phe  Ala Leu Asp Thr Ser  Glu Gly Val Asn Gln  Asp Thr Phe 
    2405                 2410                 2415             


Gly Arg  Met Arg Asp Val Val  Leu Ser Ile Val Asn  Asp Leu Thr 
    2420                 2425                 2430             


Ile Ala  Glu Ser Asn Cys Pro  Arg Gly Ala Arg Val  Ala Val Val 
    2435                 2440                 2445             


Thr Tyr  Asn Asn Glu Val Thr  Thr Glu Ile Arg Phe  Ala Asp Ser 
    2450                 2455                 2460             


Lys Arg  Lys Ser Val Leu Leu  Asp Lys Ile Lys Asn  Leu Gln Val 
    2465                 2470                 2475             


Ala Leu  Thr Ser Lys Gln Gln  Ser Leu Glu Thr Ala  Met Ser Phe 
    2480                 2485                 2490             


Val Ala  Arg Asn Thr Phe Lys  Arg Val Arg Asn Gly  Phe Leu Met 
    2495                 2500                 2505             


Arg Lys  Val Ala Val Phe Phe  Ser Asn Thr Pro Thr  Arg Ala Ser 
    2510                 2515                 2520             


Pro Gln  Leu Arg Glu Ala Val  Leu Lys Leu Ser Asp  Ala Gly Ile 
    2525                 2530                 2535             


Thr Pro  Leu Phe Leu Thr Arg  Gln Glu Asp Arg Gln  Leu Ile Asn 
    2540                 2545                 2550             


Ala Leu  Gln Ile Asn Asn Thr  Ala Val Gly His Ala  Leu Val Leu 
    2555                 2560                 2565             


Pro Ala  Gly Arg Asp Leu Thr  Asp Phe Leu Glu Asn  Val Leu Thr 
    2570                 2575                 2580             


Cys His  Val Cys Leu Asp Ile  Cys Asn Ile Asp Pro  Ser Cys Gly 
    2585                 2590                 2595             


Phe Gly  Ser Trp Arg Pro Ser  Phe Arg Asp Arg Arg  Ala Ala Gly 
    2600                 2605                 2610             


Ser Asp  Val Asp Ile Asp Met  Ala Phe Ile Leu Asp  Ser Ala Glu 
    2615                 2620                 2625             


Thr Thr  Thr Leu Phe Gln Phe  Asn Glu Met Lys Lys  Tyr Ile Ala 
    2630                 2635                 2640             


Tyr Leu  Val Arg Gln Leu Asp  Met Ser Pro Asp Pro  Lys Ala Ser 
    2645                 2650                 2655             


Gln His  Phe Ala Arg Val Ala  Val Val Gln His Ala  Pro Ser Glu 
    2660                 2665                 2670             


Ser Val  Asp Asn Ala Ser Met  Pro Pro Val Lys Val  Glu Phe Ser 
    2675                 2680                 2685             


Leu Thr  Asp Tyr Gly Ser Lys  Glu Lys Leu Val Asp  Phe Leu Ser 
    2690                 2695                 2700             


Arg Gly  Met Thr Gln Leu Gln  Gly Thr Arg Ala Leu  Gly Ser Ala 
    2705                 2710                 2715             


Ile Glu  Tyr Thr Ile Glu Asn  Val Phe Glu Ser Ala  Pro Asn Pro 
    2720                 2725                 2730             


Arg Asp  Leu Lys Ile Val Val  Leu Met Leu Thr Gly  Glu Val Pro 
    2735                 2740                 2745             


Glu Gln  Gln Leu Glu Glu Ala  Gln Arg Val Ile Leu  Gln Ala Lys 
    2750                 2755                 2760             


Cys Lys  Gly Tyr Phe Phe Val  Val Leu Gly Ile Gly  Arg Lys Val 
    2765                 2770                 2775             


Asn Ile  Lys Glu Val Tyr Thr  Phe Ala Ser Glu Pro  Asn Asp Val 
    2780                 2785                 2790             


Phe Phe  Lys Leu Val Asp Lys  Ser Thr Glu Leu Asn  Glu Glu Pro 
    2795                 2800                 2805             


Leu Met  Arg Phe Gly Arg Leu  Leu Pro Ser Phe Val  Ser Ser Glu 
    2810                 2815                 2820             


Asn Ala  Phe Tyr Leu Ser Pro  Asp Ile Arg Lys Gln  Cys Asp Trp 
    2825                 2830                 2835             


Phe Gln  Gly Asp Gln Pro Thr  Lys Asn Leu Val Lys  Phe Gly His 
    2840                 2845                 2850             


Lys Gln  Val Asn Val Pro Asn  Asn Val Thr Ser Ser  Pro Thr Ser 
    2855                 2860                 2865             


Asn Pro  Val Thr Thr Thr Lys  Pro Val Thr Thr Thr  Lys Pro Val 
    2870                 2875                 2880             


Thr Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2885                 2890                 2895             


Ile Ile  Asn Gln Pro Ser Val  Lys Pro Ala Ala Ala  Lys Pro Ala 
    2900                 2905                 2910             


Pro Ala  Lys Pro Val Ala Ala  Lys Pro Val Ala Thr  Lys Thr Ala 
    2915                 2920                 2925             


Thr Val  Arg Pro Pro Val Ala  Val Lys Pro Ala Thr  Ala Ala Lys 
    2930                 2935                 2940             


Pro Val  Ala Ala Lys Pro Ala  Ala Val Arg Pro Pro  Ala Ala Ala 
    2945                 2950                 2955             


Ala Ala  Lys Pro Val Ala Thr  Lys Pro Glu Val Pro  Arg Pro Gln 
    2960                 2965                 2970             


Ala Ala  Lys Pro Ala Ala Thr  Lys Pro Ala Thr Thr  Lys Pro Met 
    2975                 2980                 2985             


Val Lys  Met Ser Arg Glu Val  Gln Val Phe Glu Ile  Thr Glu Asn 
    2990                 2995                 3000             


Ser Ala  Lys Leu His Trp Glu  Arg Pro Glu Pro Pro  Gly Pro Tyr 
    3005                 3010                 3015             


Phe Tyr  Asp Leu Thr Val Thr  Ser Ala His Asp Gln  Ser Leu Val 
    3020                 3025                 3030             


Leu Lys  Gln Asn Leu Thr Val  Thr Asp Arg Val Ile  Gly Gly Leu 
    3035                 3040                 3045             


Leu Ala  Gly Gln Thr Tyr His  Val Ala Val Val Cys  Tyr Leu Arg 
    3050                 3055                 3060             


Ser Gln  Val Arg Ala Thr Tyr  His Gly Ser Phe Ser  Thr Lys Lys 
    3065                 3070                 3075             


Ser Gln  Pro Pro Pro Pro Gln  Pro Ala Arg Ser Ala  Ser Ser Ser 
    3080                 3085                 3090             


Thr Ile  Asn Leu Met Val Ser  Thr Glu Pro Leu Ala  Leu Thr Glu 
    3095                 3100                 3105             


Thr Asp  Ile Cys Lys Leu Pro  Lys Asp Glu Gly Thr  Cys Arg Asp 
    3110                 3115                 3120             


Phe Ile  Leu Lys Trp Tyr Tyr  Asp Pro Asn Thr Lys  Ser Cys Ala 
    3125                 3130                 3135             


Arg Phe  Trp Tyr Gly Gly Cys  Gly Gly Asn Glu Asn  Lys Phe Gly 
    3140                 3145                 3150             


Ser Gln  Lys Glu Cys Glu Lys  Val Cys Ala Pro Val  Leu Ala Lys 
    3155                 3160                 3165             


Pro Gly  Val Ile Ser Val Met  Gly Thr 
    3170                 3175         


<210>  373
<211>  3627
<212>  DNA
<213>  Homo sapiens

<400>  373
atggattctc taccagatga attttttgtg aggcatcctg ctgtggagga tcagaggaag       60

gaagaaactg agaataagct agaaaaatca tctggtcaac tgaacaaaca ggaaaatgac      120

atacctactg atcttgtccc tgttaaccta ctattagaag tgaagaagtt attaaatgca      180

attaatactc taccaaaagg tgtggttcct cacattaaga agttcttaca agaagatttt      240

tccttccaaa ctatgcagag agaagttgca gctaacagcc agaatggtga ggaaattgtt      300

cctgctttga ctttacgttt cttgattaca cagctagaag cagcacttag gaacattcaa      360

gctggcaatt ataccgcaca ccagattaat attggttatt atttgacatt actgttttta      420

tatggagtag cactcactga aagaggaaag aaagaggatt atacagaagc tgagaataaa      480

tttctggtga tgaagatgat gatccaagaa aatgaaattt gtgaaaactt tatgtcttta      540

gtttattttg gacgtggttt actgcgatgt gctcaaaaga gatataatgg aggactgcta      600

gaatttcata aaagcttaca agaaattgga gacaaaaatg accattggtt tgacatagat      660

cctacagaag atgaagattt acctacaact tttaaagatc ttcttaataa ttttatcaag      720

acaactgaaa gcaatataat gaagcagacg atttgtagtt acctagattg tgaacgatct      780

tgtgaagctg acattttgaa gaacaccagt tataagggat tttttcagtt aatgtgcagt      840

aaaagttgct gtgtttattt ccataaaatt tgctggaaaa agttcaagaa tttaaagtat      900

ccaggtgaaa atgatcagag ttttagtggg aaaaaatgtt tgaaggaagg atgtacaggt      960

gacatggtaa ggatgctgca atgtgatgta cctggaattg ttaaaatttt gtttgaagtt     1020

gtgagaaagg atgaatatat caccattgaa aatttaggag caagttatag aaagttgata     1080

tctctgaaaa taactgatac tgatataaga ccgaagatca gtttaaaatt taatacaaaa     1140

gatgaaatgc ctatcttcaa gcttgattat aattatttct atcatctgct tcatataatt     1200

attatttctg gtactgacat tgttcgacaa atatttgatg aggctatgcc acctcctctt     1260

ttgaaaaaag agcttcttat acacaagaat gtgctggaat cctactacaa ccatctttgg     1320

accaatcatc ctttgggtgg atcatggcat ctgctttatc ctcctaacaa ggagttaccg     1380

caatccaaac agtttgactt atgcctcctg ttagctctta taaaacattt aaatgtgttc     1440

cctgcaccca aaaaaggatg gaatatggaa ccgccatctt ctgacatctc taaatctgca     1500

gacatcctga gactgtgcaa atacagggat atcctcctta gtgagatttt gatgaatggt     1560

ctcactgagt cacagttcaa ttcaatttgg aaaaaagttt cagatattct tctgcgcctt     1620

gggatgatgc aagaggatat tgacaaagtg aaggagaatc ccattgagaa tatctccctt     1680

gattaccatc agctatctgt ctacctaggc ataccagtac cagaaatcat acagaggatg     1740

ttatcctgct atcaacaagg aattgctcta cagtcaataa caggcagtca gcgtattgaa     1800

atagaagagt tacagaatga ggaagaagaa ctaagtccac ctctcatgga gtacaatata     1860

aatgtgaaat cacaccctga gatacagttt gcagaaatta ataaagatgg gacctcaata     1920

cccagtgaat cttcaacaga atctcttaaa gatctccagg aagttaagag taaacaaagg     1980

aaaaagaaga agactaagaa taaaaagaat aaagactcaa aagaagacca agtcccatat     2040

gtggtagaaa aggaagagca gttgaggaaa gaacaagcaa atccacactc agtcagtaga     2100

cttataaaag atgatgcaag tgatgttcaa gaggattctg caatggaaga caagttctat     2160

agcctggatg aattgcatat tctggacatg atagagcagg gctcagctgg caaagtaact     2220

acagactatg gagaaactga aaaggaaagg cttgctcgtc aaaggcagct ttataaattg     2280

cactatcagt gtgaagattt caaaagacag ttgagaacag tgacttttcg gtggcaagaa     2340

aaccaaatgc agattaaaaa gaaagacaaa attatcgcat ctcttaatca acaagttgct     2400

tttggaatca ataaggtttc caaattacag cgtcaaatcc atgctaaaga taatgaaatc     2460

aagaacctta aagagcaact ttctatgaaa agatctcagt gggaaatgga aaaacataat     2520

ctggaaagca caatgaaaac atacgtaagc aaactgaacg cagaaactag cagagcttta     2580

acagccgagg tgtatttctt acagtgtcgt agggattttg gtttgcttca tctagagcag     2640

actgaaaagg aatgtctcaa tcagcttgcc agggtgactc acatggcagc aagcaaccta     2700

gaatcacttc aattaaaggc tgcggtagac agttggaatg ccattgtggc agatgttaga     2760

aacaagattg cattcctcag gacacagtac aatgaacaaa taaacaaagt caagcaagga     2820

tttgccttga gtaccttgcc tccagtccag cttcctcctc caccacccag tcctgagata     2880

ctgatgcagc agttcttagg aagacctctt gtgaaagaat ctttctttag acccatactt     2940

actgttcctc aaatgcctgc agtttgcccg ggagtcgtct ctgcaactgg ccaacctaga     3000

gcccccctga tgactggcat agcctgggct ctgccagcgc ctgtgggaga cgctgtgcct     3060

cccagtgcag gtctgcggag tgatccctcc atcatgaatt gggagagaat tacagacagg     3120

ctgaaaactg cctttccaca gcaaaccaga aaggaactta cagatttctt acggaaattg     3180

aaggatgctt atggaaaatc cttgtctgaa ctgacatttg atgaaattgt ttgcaagatt     3240

tcccagttta ttgaccccaa aaagtctcag agtcaaggaa aatcagtgtc aaatgttaat     3300

tgtgtttcac ctagtcattc tccatcacag cctgatgctg cccagccccc aaaaccagcc     3360

tggaggccac tcacttcaca gggtcctgcc acatgggaag gagccagtaa tccagatgag     3420

gaagaggaag aagaagagcc ttgtgtgatc tgtcatgaga atctgtctcc agaaaatctt     3480

tcagttttgc cttgcgctca caaattccat gctcagtgca ttagaccatg gttgatgcaa     3540

caggggacat gtccaacgtg cagactccac gttttgctac cagaagaatt ccctggtcac     3600

cccagccggc agttgcccaa gatctga                                         3627


<210>  374
<211>  1208
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Asp Ser Leu Pro Asp Glu Phe Phe Val Arg His Pro Ala Val Glu 
1               5                   10                  15      


Asp Gln Arg Lys Glu Glu Thr Glu Asn Lys Leu Glu Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Asn Lys Gln Glu Asn Asp Ile Pro Thr Asp Leu Val Pro Val 
        35                  40                  45              


Asn Leu Leu Leu Glu Val Lys Lys Leu Leu Asn Ala Ile Asn Thr Leu 
    50                  55                  60                  


Pro Lys Gly Val Val Pro His Ile Lys Lys Phe Leu Gln Glu Asp Phe 
65                  70                  75                  80  


Ser Phe Gln Thr Met Gln Arg Glu Val Ala Ala Asn Ser Gln Asn Gly 
                85                  90                  95      


Glu Glu Ile Val Pro Ala Leu Thr Leu Arg Phe Leu Ile Thr Gln Leu 
            100                 105                 110         


Glu Ala Ala Leu Arg Asn Ile Gln Ala Gly Asn Tyr Thr Ala His Gln 
        115                 120                 125             


Ile Asn Ile Gly Tyr Tyr Leu Thr Leu Leu Phe Leu Tyr Gly Val Ala 
    130                 135                 140                 


Leu Thr Glu Arg Gly Lys Lys Glu Asp Tyr Thr Glu Ala Glu Asn Lys 
145                 150                 155                 160 


Phe Leu Val Met Lys Met Met Ile Gln Glu Asn Glu Ile Cys Glu Asn 
                165                 170                 175     


Phe Met Ser Leu Val Tyr Phe Gly Arg Gly Leu Leu Arg Cys Ala Gln 
            180                 185                 190         


Lys Arg Tyr Asn Gly Gly Leu Leu Glu Phe His Lys Ser Leu Gln Glu 
        195                 200                 205             


Ile Gly Asp Lys Asn Asp His Trp Phe Asp Ile Asp Pro Thr Glu Asp 
    210                 215                 220                 


Glu Asp Leu Pro Thr Thr Phe Lys Asp Leu Leu Asn Asn Phe Ile Lys 
225                 230                 235                 240 


Thr Thr Glu Ser Asn Ile Met Lys Gln Thr Ile Cys Ser Tyr Leu Asp 
                245                 250                 255     


Cys Glu Arg Ser Cys Glu Ala Asp Ile Leu Lys Asn Thr Ser Tyr Lys 
            260                 265                 270         


Gly Phe Phe Gln Leu Met Cys Ser Lys Ser Cys Cys Val Tyr Phe His 
        275                 280                 285             


Lys Ile Cys Trp Lys Lys Phe Lys Asn Leu Lys Tyr Pro Gly Glu Asn 
    290                 295                 300                 


Asp Gln Ser Phe Ser Gly Lys Lys Cys Leu Lys Glu Gly Cys Thr Gly 
305                 310                 315                 320 


Asp Met Val Arg Met Leu Gln Cys Asp Val Pro Gly Ile Val Lys Ile 
                325                 330                 335     


Leu Phe Glu Val Val Arg Lys Asp Glu Tyr Ile Thr Ile Glu Asn Leu 
            340                 345                 350         


Gly Ala Ser Tyr Arg Lys Leu Ile Ser Leu Lys Ile Thr Asp Thr Asp 
        355                 360                 365             


Ile Arg Pro Lys Ile Ser Leu Lys Phe Asn Thr Lys Asp Glu Met Pro 
    370                 375                 380                 


Ile Phe Lys Leu Asp Tyr Asn Tyr Phe Tyr His Leu Leu His Ile Ile 
385                 390                 395                 400 


Ile Ile Ser Gly Thr Asp Ile Val Arg Gln Ile Phe Asp Glu Ala Met 
                405                 410                 415     


Pro Pro Pro Leu Leu Lys Lys Glu Leu Leu Ile His Lys Asn Val Leu 
            420                 425                 430         


Glu Ser Tyr Tyr Asn His Leu Trp Thr Asn His Pro Leu Gly Gly Ser 
        435                 440                 445             


Trp His Leu Leu Tyr Pro Pro Asn Lys Glu Leu Pro Gln Ser Lys Gln 
    450                 455                 460                 


Phe Asp Leu Cys Leu Leu Leu Ala Leu Ile Lys His Leu Asn Val Phe 
465                 470                 475                 480 


Pro Ala Pro Lys Lys Gly Trp Asn Met Glu Pro Pro Ser Ser Asp Ile 
                485                 490                 495     


Ser Lys Ser Ala Asp Ile Leu Arg Leu Cys Lys Tyr Arg Asp Ile Leu 
            500                 505                 510         


Leu Ser Glu Ile Leu Met Asn Gly Leu Thr Glu Ser Gln Phe Asn Ser 
        515                 520                 525             


Ile Trp Lys Lys Val Ser Asp Ile Leu Leu Arg Leu Gly Met Met Gln 
    530                 535                 540                 


Glu Asp Ile Asp Lys Val Lys Glu Asn Pro Ile Glu Asn Ile Ser Leu 
545                 550                 555                 560 


Asp Tyr His Gln Leu Ser Val Tyr Leu Gly Ile Pro Val Pro Glu Ile 
                565                 570                 575     


Ile Gln Arg Met Leu Ser Cys Tyr Gln Gln Gly Ile Ala Leu Gln Ser 
            580                 585                 590         


Ile Thr Gly Ser Gln Arg Ile Glu Ile Glu Glu Leu Gln Asn Glu Glu 
        595                 600                 605             


Glu Glu Leu Ser Pro Pro Leu Met Glu Tyr Asn Ile Asn Val Lys Ser 
    610                 615                 620                 


His Pro Glu Ile Gln Phe Ala Glu Ile Asn Lys Asp Gly Thr Ser Ile 
625                 630                 635                 640 


Pro Ser Glu Ser Ser Thr Glu Ser Leu Lys Asp Leu Gln Glu Val Lys 
                645                 650                 655     


Ser Lys Gln Arg Lys Lys Lys Lys Thr Lys Asn Lys Lys Asn Lys Asp 
            660                 665                 670         


Ser Lys Glu Asp Gln Val Pro Tyr Val Val Glu Lys Glu Glu Gln Leu 
        675                 680                 685             


Arg Lys Glu Gln Ala Asn Pro His Ser Val Ser Arg Leu Ile Lys Asp 
    690                 695                 700                 


Asp Ala Ser Asp Val Gln Glu Asp Ser Ala Met Glu Asp Lys Phe Tyr 
705                 710                 715                 720 


Ser Leu Asp Glu Leu His Ile Leu Asp Met Ile Glu Gln Gly Ser Ala 
                725                 730                 735     


Gly Lys Val Thr Thr Asp Tyr Gly Glu Thr Glu Lys Glu Arg Leu Ala 
            740                 745                 750         


Arg Gln Arg Gln Leu Tyr Lys Leu His Tyr Gln Cys Glu Asp Phe Lys 
        755                 760                 765             


Arg Gln Leu Arg Thr Val Thr Phe Arg Trp Gln Glu Asn Gln Met Gln 
    770                 775                 780                 


Ile Lys Lys Lys Asp Lys Ile Ile Ala Ser Leu Asn Gln Gln Val Ala 
785                 790                 795                 800 


Phe Gly Ile Asn Lys Val Ser Lys Leu Gln Arg Gln Ile His Ala Lys 
                805                 810                 815     


Asp Asn Glu Ile Lys Asn Leu Lys Glu Gln Leu Ser Met Lys Arg Ser 
            820                 825                 830         


Gln Trp Glu Met Glu Lys His Asn Leu Glu Ser Thr Met Lys Thr Tyr 
        835                 840                 845             


Val Ser Lys Leu Asn Ala Glu Thr Ser Arg Ala Leu Thr Ala Glu Val 
    850                 855                 860                 


Tyr Phe Leu Gln Cys Arg Arg Asp Phe Gly Leu Leu His Leu Glu Gln 
865                 870                 875                 880 


Thr Glu Lys Glu Cys Leu Asn Gln Leu Ala Arg Val Thr His Met Ala 
                885                 890                 895     


Ala Ser Asn Leu Glu Ser Leu Gln Leu Lys Ala Ala Val Asp Ser Trp 
            900                 905                 910         


Asn Ala Ile Val Ala Asp Val Arg Asn Lys Ile Ala Phe Leu Arg Thr 
        915                 920                 925             


Gln Tyr Asn Glu Gln Ile Asn Lys Val Lys Gln Gly Phe Ala Leu Ser 
    930                 935                 940                 


Thr Leu Pro Pro Val Gln Leu Pro Pro Pro Pro Pro Ser Pro Glu Ile 
945                 950                 955                 960 


Leu Met Gln Gln Phe Leu Gly Arg Pro Leu Val Lys Glu Ser Phe Phe 
                965                 970                 975     


Arg Pro Ile Leu Thr Val Pro Gln Met Pro Ala Val Cys Pro Gly Val 
            980                 985                 990         


Val Ser Ala Thr Gly Gln Pro Arg  Ala Pro Leu Met Thr  Gly Ile Ala 
        995                 1000                 1005             


Trp Ala  Leu Pro Ala Pro Val  Gly Asp Ala Val Pro  Pro Ser Ala 
    1010                 1015                 1020             


Gly Leu  Arg Ser Asp Pro Ser  Ile Met Asn Trp Glu  Arg Ile Thr 
    1025                 1030                 1035             


Asp Arg  Leu Lys Thr Ala Phe  Pro Gln Gln Thr Arg  Lys Glu Leu 
    1040                 1045                 1050             


Thr Asp  Phe Leu Arg Lys Leu  Lys Asp Ala Tyr Gly  Lys Ser Leu 
    1055                 1060                 1065             


Ser Glu  Leu Thr Phe Asp Glu  Ile Val Cys Lys Ile  Ser Gln Phe 
    1070                 1075                 1080             


Ile Asp  Pro Lys Lys Ser Gln  Ser Gln Gly Lys Ser  Val Ser Asn 
    1085                 1090                 1095             


Val Asn  Cys Val Ser Pro Ser  His Ser Pro Ser Gln  Pro Asp Ala 
    1100                 1105                 1110             


Ala Gln  Pro Pro Lys Pro Ala  Trp Arg Pro Leu Thr  Ser Gln Gly 
    1115                 1120                 1125             


Pro Ala  Thr Trp Glu Gly Ala  Ser Asn Pro Asp Glu  Glu Glu Glu 
    1130                 1135                 1140             


Glu Glu  Glu Pro Cys Val Ile  Cys His Glu Asn Leu  Ser Pro Glu 
    1145                 1150                 1155             


Asn Leu  Ser Val Leu Pro Cys  Ala His Lys Phe His  Ala Gln Cys 
    1160                 1165                 1170             


Ile Arg  Pro Trp Leu Met Gln  Gln Gly Thr Cys Pro  Thr Cys Arg 
    1175                 1180                 1185             


Leu His  Val Leu Leu Pro Glu  Glu Phe Pro Gly His  Pro Ser Arg 
    1190                 1195                 1200             


Gln Leu  Pro Lys Ile 
    1205             


<210>  375
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  375
atgggagaac ctgcgttcac ctcttttcca agcctgcctg ttctggggaa gctcaaaagg       60

aacatgatgc cctgggcttt acagaagaaa cgagaaatcc acatggccaa ggcccatcgg      120

agacgagctg cgaggtctgc tctccccatg agactcacca gctgcatctt ccggaggccg      180

gtgacaagga tcaggtctca tcctgacaac caggtcagac gcagaaaagg ggacgagcac      240

ctggagaagc cgcagcaact ctgcgcctac cggagactgc aggccctgca gccctgcagc      300

agccaaggag aaggttcaag tccactgcat ttggagagcg tcttaagtat ccttgcaccg      360

gggacggccg gtgaatctct ggacagagct ggtgctgagc gtgtgcgcag cccgcttgag      420

cccacccctg ggcggtttcc agctgtggca ggggggccaa ccccaggaat gggttgtcag      480

ctcccaccgc ccctctctgg ccaattggtg actcctgcag atatccggag acaggccagg      540

agggtgaaga aagccaggga gagactggcc aaggccttgc aggcagacag gctggccagg      600

cgggcagaaa tgctgacagg tggatga                                          627


<210>  376
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Gly Glu Pro Ala Phe Thr Ser Phe Pro Ser Leu Pro Val Leu Gly 
1               5                   10                  15      


Lys Leu Lys Arg Asn Met Met Pro Trp Ala Leu Gln Lys Lys Arg Glu 
            20                  25                  30          


Ile His Met Ala Lys Ala His Arg Arg Arg Ala Ala Arg Ser Ala Leu 
        35                  40                  45              


Pro Met Arg Leu Thr Ser Cys Ile Phe Arg Arg Pro Val Thr Arg Ile 
    50                  55                  60                  


Arg Ser His Pro Asp Asn Gln Val Arg Arg Arg Lys Gly Asp Glu His 
65                  70                  75                  80  


Leu Glu Lys Pro Gln Gln Leu Cys Ala Tyr Arg Arg Leu Gln Ala Leu 
                85                  90                  95      


Gln Pro Cys Ser Ser Gln Gly Glu Gly Ser Ser Pro Leu His Leu Glu 
            100                 105                 110         


Ser Val Leu Ser Ile Leu Ala Pro Gly Thr Ala Ser Glu Ser Leu Asp 
        115                 120                 125             


Arg Ala Gly Ala Glu Arg Val Arg Ser Pro Leu Glu Pro Thr Pro Gly 
    130                 135                 140                 


Arg Phe Pro Ala Val Ala Gly Gly Pro Thr Pro Gly Met Gly Cys Gln 
145                 150                 155                 160 


Leu Pro Pro Pro Leu Ser Gly Gln Leu Val Thr Pro Ala Asp Ile Arg 
                165                 170                 175     


Arg Gln Ala Arg Arg Val Lys Lys Ala Arg Glu Arg Leu Ala Lys Ala 
            180                 185                 190         


Leu Gln Ala Asp Arg Leu Ala Arg Arg Ala Glu Met 
        195                 200                 


<210>  377
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  377
atgtccaagt acaaacttat tatgttaaga catggagagg gtgcttggaa taaggagaac       60

cgtttttgta gctgggtgga tcagaaactc aacagcgaag gaatggagga agctcggaac      120

tgtgggaagc aactcaaagc gttaaacttt gagtttgatc ttgtattcac atctgtcctt      180

aatcggtcca ttcacacagc ctggctgatc ctggaagagc taggccagga atgggtgcct      240

gtggaaagct cctggcgtct aaatgagcgt cactatgggg ccttgatcgg tctcaacagg      300

gagcagatgg ctttgaatca tggtgaagaa caagtgaggc tctggagaag aagctacaat      360

gtaaccccgc ctcccattga ggagtctcat ccttactacc aagaaatcta caacgaccgg      420

aggtataaag tatgcgatgt gcccttggat caactgccac ggtcggaaag cttaaaggat      480

gttctggaga gactccttcc ctattggaat gaaaggattg ctcccgaagt attacgtggc      540

aaaaccattc tgatatctgc tcatggaaat agcagtaggg cactcctaaa acacctggaa      600

ggtatctcag atgaagacat catcaacatt actcttccta ctggagtccc cattcttctg      660

gaattggatg aaaacctgcg tgctgttggg cctcatcagt tcctgggtga ccaagaggcg      720

atccaagcag ccattaagaa agtagaagat caaggaaaag tgaaacaagc taaaaaatag      780


<210>  378
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp 
1               5                   10                  15      


Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser 
            20                  25                  30          


Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu 
        35                  40                  45              


Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile 
    50                  55                  60                  


His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro 
65                  70                  75                  80  


Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile 
                85                  90                  95      


Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val 
            100                 105                 110         


Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu 
        115                 120                 125             


Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val 
    130                 135                 140                 


Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp 
145                 150                 155                 160 


Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu 
                165                 170                 175     


Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser 
            180                 185                 190         


Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile 
        195                 200                 205             


Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu 
    210                 215                 220                 


Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala 
225                 230                 235                 240 


Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln 
                245                 250                 255     


Ala Lys Lys 
            


<210>  379
<211>  3599
<212>  DNA
<213>  Homo sapiens

<400>  379
gcgatcgctt tcgaaggaga tagaaccatg gatatctcta ctcgctccaa agatcctggc       60

tctgcagaga gaacagccca gaaaagaaag ttccccagcc ctccacattc ttccaatggc      120

cactcgccgc aggacacatc aacaagcccc attaaaaaga aaaagaaacc tggcttactg      180

aacagtaaca ataaggagca gtcagaacta agacatggtc cgttttacta tatgaagcag      240

ccactcacca cagaccctgt tgatgttgta ccgcaggatg gacggaatga tttctactgc      300

tgggtttgtc accgggaagg ccaagtcctt tgctgtgagc tctgtccccg ggtttatcac      360

gctaagtgtc tgagactgac atcggaacca gagggggact ggttttgtcc tgaatgtgag      420

aaaattacag tagcagaatg catcgagacc cagagtaaag ccatgacaat gctcaccatt      480

gaacagttat cctacctgct caagtttgcc attcagaaaa tgaaacagcc agggacagat      540

gcattccaga agcccgttcc attggaacag caccctgact atgcggaata catcttccat      600

ccaatggacc tttgtacatt ggaaaagaat gcgaaaaaga aaatgtatgg ctgcacagaa      660

gccttcctgg ctgatgcaaa gtggattttg cacaactgca tcatttataa tgggggaaat      720

cacaaattga cgcaaatagc gaaagtagtc atcaaaatct gtgaacatga gatgaatgaa      780

atcgaagtat gtccagaatg ttatctagct gcttgccaaa aacgagataa ctggttttgt      840

gagccttgta gcaatccaca tcctttggtc tgggccaaac tgaaggggtt tccattctgg      900

cctgcaaaag ctctaaggga taaagacggg caggtcgatg cccgattctt tggacaacat      960

gacagggcct gggttccaat aaataattgc tacctcatgt ctaaagaaat tcctttttct     1020

gtgaaaaaga ctaagagcat cttcaacagt gccatgcaag agatggaggt ttacgtggag     1080

aacatccgca ggaagtttgg ggtttttaat tactctccat ttaggacacc ctacacaccc     1140

aacagccagt atcaaatgct gctcgatccc accaacccca gcgccggcac tgccaagata     1200

gacaagcagg agaaggtcaa gctcaacttt gacatgacgg catcccccaa gatcctgatg     1260

agcaagcctg tgctgagtgg gggcacaggc cgccggattt ccttgtcgga tatgccgcgc     1320

tcccccatga gcacaaactc ttctgtgcac acgggctccg acgtggagca ggatgctgag     1380

aagaaggcca cgtcgagcca cttcagtgcg agcgaggagt ccatggactt cctggataag     1440

agcacagctt caccagcctc caccaagacg ggacaagcag ggagtttatc cggcagccca     1500

aagcccttct ctcctcaact gtcagctcct atcacgacga aaacggacaa aacctccacc     1560

accggcagca tcctgaatct taacctggat cgaagcaaag ctgagatgga tttgaaggag     1620

ctgagcgagt cggtccagca acagtccacc cctgttcctc tcatctctcc caagcgccag     1680

attcgtagca ggttccagct gaatcttgac aagaccatag agagttgcaa agcacaatta     1740

ggcataaatg aaatctcgga agatgtctat acggccgtag agcacagcga ttcggaggat     1800

tctgagaagt cagatagtag cgatagtgag tatatcagtg atgatgagca gaagtctaag     1860

aacgagccag aagacacaga ggacaaagaa ggttgtcaga tggacaaaga gccatctgct     1920

gttaaaaaaa agcccaagcc tacaaaccca gtggagatta aagaggagct gaaaagcacg     1980

tcaccagcca gcgagaaggc agaccctgga gcagtcaagg acaaggccag ccctgagcct     2040

gagaaggact tttccgaaaa ggcaaaacct tcacctcacc ccataaagga taaactgaag     2100

ggaaaagatg agacggattc cccaacagtc catttgggcc tggactctga ttcagagagc     2160

gaacttgtca tagatttagg agaagaccat tctgggcggg agggtcgaaa aaataagaag     2220

gaacccaaag aaccatctcc caaacaggat gttgtaggta aaactccacc atccacgacg     2280

gtgggcagcc attctccccc ggaaacaccg gtgctcaccc gctcttccgc ccaaacttcc     2340

gcggctggcg ccacagccac caccagcacg tcctccacgg tcaccgtcac ggccccggcc     2400

cccgccgcca caggaagccc agtgaaaaag cagaggccgc ttttaccgaa ggagactgcc     2460

ccggccgtgc agcgggtcgt gtggaactca tcaagtaagt ttcaaacgtc ctcccaaaag     2520

tggcacatgc agaagatgca gcgtcagcag cagcagcagc agcagcaaaa ccagcagcag     2580

cagcctcagt cttcccaggg gacgagatat cagaccagac aggctgtgaa agctgtccag     2640

cagaaggaga tcacacagag cccatccacg tccaccatca ccctggtgac cagcacacag     2700

tcatcgcccc tggtcaccag ctcggggtcc atgagcaccc ttgtgtcctc agtcaacgct     2760

gacctgccca tcgccactgc ctcagctgat gtcgccgctg atattgccaa gtacactagc     2820

aaaatgatgg atgcaataaa aggaacaatg acagaaatat acaacgatct ttctaaaaac     2880

actactggaa gcacaatagc tgagattcgc aggctgagga tcgagataga gaagctccag     2940

tggctgcacc agcaagagct ctccgaaatg aaacacaact tagagctgac catggcggag     3000

atgcggcaga gcctggagca ggagcgggac cggctcatcg ccgaggtgaa gaagcagctg     3060

gagttggaga agcagcaggc ggtggatgag accaagaaga agcagtggtg cgccaactgc     3120

aagaaggagg ccatctttta ctgctgttgg aacaccagct actgtgacta cccctgccag     3180

caagcccact ggcctgagca catgaagtcc tgcacccagt cagctactgc tcctcagcag     3240

gaagcggatg ctgaggtgaa cacagaaaca ctaaataagt cctcccaggg gagctcctcg     3300

agcacacaat cagcaccttc agaaacggcc agcgcctcca aagagaagga gacgtcagct     3360

gagaaaagca aggagagtgg ctcgaccctt gacctttctg gctccagaga gacgccctcc     3420

tccattctct taggctccaa ccaaggctct gaccattccc ggagtaataa atccagttgg     3480

agcagcagtg atgagaagag gggatcgaca cgttccgatc acaacaccag taccagcacg     3540

aagagcctcc tcccgaaaga gtctcggctg gacaccttct gggactacgt agtttaaac      3599


<210>  380
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr 
1               5                   10                  15      


Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His 
            20                  25                  30          


Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro 
        35                  40                  45              


Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu Leu Arg His Gly 
    50                  55                  60                  


Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp Pro Val Asp Val 
65                  70                  75                  80  


Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg 
                85                  90                  95      


Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala 
            100                 105                 110         


Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro 
        115                 120                 125             


Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys 
    130                 135                 140                 


Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe 
145                 150                 155                 160 


Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro 
                165                 170                 175     


Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro 
            180                 185                 190         


Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly 
        195                 200                 205             


Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys 
    210                 215                 220                 


Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val 
225                 230                 235                 240 


Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile Glu Val Cys Pro 
                245                 250                 255     


Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu 
            260                 265                 270         


Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe 
        275                 280                 285             


Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp 
    290                 295                 300                 


Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn 
305                 310                 315                 320 


Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys 
                325                 330                 335     


Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn 
            340                 345                 350         


Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro 
        355                 360                 365             


Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro 
    370                 375                 380                 


Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn 
385                 390                 395                 400 


Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu 
                405                 410                 415     


Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser 
            420                 425                 430         


Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser Asp Val Glu Gln 
        435                 440                 445             


Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu 
    450                 455                 460                 


Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys 
465                 470                 475                 480 


Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro 
                485                 490                 495     


Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr 
            500                 505                 510         


Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp 
        515                 520                 525             


Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro 
    530                 535                 540                 


Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu 
545                 550                 555                 560 


Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile 
                565                 570                 575     


Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser 
            580                 585                 590         


Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln 
        595                 600                 605             


Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln 
    610                 615                 620                 


Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn 
625                 630                 635                 640 


Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu 
                645                 650                 655     


Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu 
            660                 665                 670         


Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp 
        675                 680                 685             


Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly 
    690                 695                 700                 


Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp 
705                 710                 715                 720 


His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro 
                725                 730                 735     


Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val 
            740                 745                 750         


Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala 
        755                 760                 765             


Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr 
    770                 775                 780                 


Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys 
785                 790                 795                 800 


Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg 
                805                 810                 815     


Val Val Trp Asn Ser Ser Ser Lys Phe Gln Thr Ser Ser Gln Lys Trp 
            820                 825                 830         


His Met Gln Lys Met Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Asn 
        835                 840                 845             


Gln Gln Gln Gln Pro Gln Ser Ser Gln Gly Thr Arg Tyr Gln Thr Arg 
    850                 855                 860                 


Gln Ala Val Lys Ala Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser 
865                 870                 875                 880 


Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val 
                885                 890                 895     


Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp 
            900                 905                 910         


Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys 
        915                 920                 925             


Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile 
    930                 935                 940                 


Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile 
945                 950                 955                 960 


Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln 
                965                 970                 975     


Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu Met 
            980                 985                 990         


Arg Gln Ser Leu Glu Gln Glu Arg  Asp Arg Leu Ile Ala  Glu Val Lys 
        995                 1000                 1005             


Lys Gln  Leu Glu Leu Glu Lys  Gln Gln Ala Val Asp  Glu Thr Lys 
    1010                 1015                 1020             


Lys Lys  Gln Trp Cys Ala Asn  Cys Lys Lys Glu Ala  Ile Phe Tyr 
    1025                 1030                 1035             


Cys Cys  Trp Asn Thr Ser Tyr  Cys Asp Tyr Pro Cys  Gln Gln Ala 
    1040                 1045                 1050             


His Trp  Pro Glu His Met Lys  Ser Cys Thr Gln Ser  Ala Thr Ala 
    1055                 1060                 1065             


Pro Gln  Gln Glu Ala Asp Ala  Glu Val Asn Thr Glu  Thr Leu Asn 
    1070                 1075                 1080             


Lys Ser  Ser Gln Gly Ser Ser  Ser Ser Thr Gln Ser  Ala Pro Ser 
    1085                 1090                 1095             


Glu Thr  Ala Ser Ala Ser Lys  Glu Lys Glu Thr Ser  Ala Glu Lys 
    1100                 1105                 1110             


Ser Lys  Glu Ser Gly Ser Thr  Leu Asp Leu Ser Gly  Ser Arg Glu 
    1115                 1120                 1125             


Thr Pro  Ser Ser Ile Leu Leu  Gly Ser Asn Gln Gly  Ser Asp His 
    1130                 1135                 1140             


Ser Arg  Ser Asn Lys Ser Ser  Trp Ser Ser Ser Asp  Glu Lys Arg 
    1145                 1150                 1155             


Gly Ser  Thr Arg Ser Asp His  Asn Thr Ser Thr Ser  Thr Lys Ser 
    1160                 1165                 1170             


Leu Leu  Pro Lys Glu Ser Arg  Leu Asp Thr Phe Trp  Asp 
    1175                 1180                 1185     


<210>  381
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  381
atggtgttgg aaagcactat ggtgtgtgtg gacaacagtg agtatatgcg gaatggagac       60

ttcttaccca ccaggctgca ggcccagcag gatgctgtca acatagtttg tcattcaaag      120

acccgcagca accctgagaa caacgtgggc cttatcacac tggctaatga ctgtgaagtg      180

ctgaccacac tcaccccaga cactggccgt atcctgtcca agctacatac tgtccaaccc      240

aagggcaaga tcaccttctg cacgggcatc cgcgtggccc atctggctct gaagcaccga      300

caaggcaaga atcacaagat gcgcatcatt gcctttgtgg gaagcccagt ggaggacaat      360

gagaaggatc tggtgaaact ggctaaacgc ctcaagaagg agaaagtaaa tgttgacatt      420

atcaattttg gggaagagga ggtgaacaca gaaaagctga cagcctttgt aaacacgttg      480

aatggcaaag atggaaccgg ttctcatctg gtgacagtgc ctcctgggcc cagtttggct      540

gatgctctca tcagttctcc gattttggct ggtgaaggtg gtgccatgct gggtcttggt      600

gccagtgact ttgaatttgg agtagatccc agtgctgatc ctgagctggc cttggccctt      660

cgtgtatcta tggaagagca gcggcagcgg caggaggagg aggcccggcg ggcagctgca      720

gcttctgctg ctgaggccgg gattgctacg actgggactg aagactcaga cgatgccctg      780

ctgaagatga ccatcagcca gcaagagttt ggccgcactg ggcttcctga cctaagcagt      840

atgactgagg aagagcagat tgcttatgcc atgcagatgt ccctgcaggg agcagagttt      900

ggccaggcgg aatcagcaga cattgatgcc agctcagcta tggacacatc tgagccagcc      960

aaggaggagg atgattacga cgtgatgcag gaccccgagt tccttcagag tgtcctagag     1020

aacctcccag gtgtggatcc caacaatgaa gccattcgaa atgctatggg ctccctggcc     1080

tcccaggcca ccaaggacgg caagaaggac aagaaggagg aagacaagaa gtga           1134


<210>  382
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Val Leu Glu Ser Thr Met Val Cys Val Asp Asn Ser Glu Tyr Met 
1               5                   10                  15      


Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp Ala 
            20                  25                  30          


Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn Asn 
        35                  40                  45              


Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr Leu 
    50                  55                  60                  


Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln Pro 
65                  70                  75                  80  


Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu Ala 
                85                  90                  95      


Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala Phe 
            100                 105                 110         


Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu Ala 
        115                 120                 125             


Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe Gly 
    130                 135                 140                 


Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr Leu 
145                 150                 155                 160 


Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly Glu 
            180                 185                 190         


Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly Val 
        195                 200                 205             


Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu Ala Leu Arg Val Ser Met 
    210                 215                 220                 


Glu Glu Gln Arg Gln Arg Gln Glu Glu Glu Ala Arg Arg Ala Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Ala Glu Ala Gly Ile Ala Thr Thr Gly Thr Glu Asp Ser 
                245                 250                 255     


Asp Asp Ala Leu Leu Lys Met Thr Ile Ser Gln Gln Glu Phe Gly Arg 
            260                 265                 270         


Thr Gly Leu Pro Asp Leu Ser Ser Met Thr Glu Glu Glu Gln Ile Ala 
        275                 280                 285             


Tyr Ala Met Gln Met Ser Leu Gln Gly Ala Glu Phe Gly Gln Ala Glu 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ala Ser Ser Ala Met Asp Thr Ser Glu Pro Ala 
305                 310                 315                 320 


Lys Glu Glu Asp Asp Tyr Asp Val Met Gln Asp Pro Glu Phe Leu Gln 
                325                 330                 335     


Ser Val Leu Glu Asn Leu Pro Gly Val Asp Pro Asn Asn Glu Ala Ile 
            340                 345                 350         


Arg Asn Ala Met Gly Ser Leu Ala Ser Gln Ala Thr Lys Asp Gly Lys 
        355                 360                 365             


Lys Asp Lys Lys Glu Glu Asp Lys Lys 
    370                 375         


<210>  383
<211>  4869
<212>  DNA
<213>  Homo sapiens

<400>  383
atggaggcag aggtgtggga ggcagaaggc tacaacctag ttctggactc ggacctgtat       60

gatgcggatg gctatgatgt cccagaccct gggctgctca ccgaaaagaa tgagttgact      120

ttcacggagc cgtcgcaggt cctgcccttt ttgaccagca gccaacagtg gcaaagcctg      180

accccgcgcg cccgcgcccg ccggctgtgg ctgcttctgc gcaccagcct ccacgaagtc      240

gtggaaaagg agaagagagc cgagctgcgc gcggcgcgcc tgacgcatgg gctggaacca      300

ctgcgccgcc tggaggtggc agccgggctg cgctcggtgg cgcaggaccc ggtgggtgga      360

cgcttcgtgg tgctggacgg cgcgggccgc ctgcacctgc acaaggaaga cggctgggca      420

caggagacgc tgctggcgcc tgtccggctt acggggctgg tgaccgtgct gggcccgctg      480

ggtgccgtgg gccgttttgt aggctggggc cccgcggggc tggcaattct gaggcccaac      540

ctcagcctgc tgtggctgag cgagcagggg gtgggcaggg ccccgggttg ggcgcccacc      600

tgctgcctgc cggttcccga cctcaggctg ctgctcgttg cggagatgaa cagcagcctg      660

gcgctctggc agttccgttc aggtggtcgc cgcctggtgc tgcgagggtc agcactgcac      720

ccgcccccga gcccaacagg caggctcatg cgtctggctg tggcgccggt tcctccccac      780

cacgtcctgc gctgcttcgc ggcctatggc tcggccgtgc tcaccttcga tctgcatgcc      840

tggactctcg tagatgtgcg ccgggatttg cacaaaacca ccatctcgga cctggcttac      900

tgcgaggaag tagaggcaat ggtgacagct tcccgggaca gcaccgtgaa ggtgtgggag      960

gctgactggc agatccggat ggtgttcgtg ggccacacag gcccggtgac ggctatgact     1020

gtgctcccga acacgaccct ggtgttgtcg gcctcgcagg acgggacgct acgcacctgg     1080

gacctgcagg cggcggcgca ggtgggcgag gtagcgctgg gcttctgggg ccaggacaag     1140

ctgtcccggc gcgtgggccg tctgctggcg ccggtgcgcc cgggctggcc ggtgctgtcc     1200

ctgtgcgcga gcagcatgca gctgtggcgc gtacgcgagc tctactcgcc gttggcgcaa     1260

ctgcccgcca aggtgctcca cgtgcaggtg gcgcccgcgt tgcccgcgcc tgcgcaccag     1320

tcgctgccta cgcgcctcgt gtgcgcgtgc gccgacggct cggtctacct cctgtcggcg     1380

gccaccgggc gcatagtgag ctcactgctg ctggagccgg aggactgcgc ggcagccgtg     1440

gcctactgcc tgccgcgcga ggcgctgtgg ctgctgacca gggctgggca cctggtccgc     1500

gccaacgcgg cgcgctgccc catgagcgtg ctgcaccgcg tgtgcccgcc gccgccccct     1560

gcgccgcagc cttgctgtct gcacctgtac agccacctca cggatctcga aggcgccttc     1620

tcctcctggg agatcgtgcg ccagcactgg ggcgagttgc gctgcagctc tgtggcctgc     1680

gcctggaaga acaagaaccg gtacctgcca gtggtggggc acacggacgg cacgctgtcg     1740

gtgctggagt ggctctcgtc gaagactgtc ttccaaacgg aggcgcacag cccgggcccg     1800

gttgtcgcca tcgcatccac ctggaacagc attgtgtctt cgggtgggga cctgacggtg     1860

aagatgtggc gcgtcttccc ctatgccgaa gagagcctga gcctgctgcg caccttctcc     1920

tgctgctacc cggccgtggc gctctgtgcg ctaggcagac gcgtcaccgc gggctttgag     1980

gacccagaca gcgctaccta cggcctggtg cagtttggcc tgggcgacag tccgcgatta     2040

gaccaccggc cccaggacga ccccacggac cacatcactg gcctgtgctg ctgccccacg     2100

ctcaaactgt atgcctgctc cagcctggac tgcaccgttc gcatctggac tgctgagaac     2160

cgcctcctgc ggctcctgca gctgaatggt gcccctcagg ccctggcttt ctgcagcaac     2220

agtggagacc tggtgctggc gctgggatcc cgcctctgcc tggtgtccca caggctctac     2280

ctgcctacat cctacctagt taagaagatg tgccggaagg ccccagacgt ggtggacgac     2340

cctccgctgc cactgatgag ccaggagtca ctgacttccg cccaactgca gaggctcacc     2400

aacctccatg gggcagccag cctcagcgag gccttgtctc tcatccatcg tcggagggca     2460

acatctcagc acctggtgcc gaaggaggac ttggacgcca tagtggcccg ggaccgagac     2520

cttcagcagt tgaggctggg gctagtggtc ccagcagccc agcccccacc ctcctggcag     2580

cagcgccagg aaggctttga caattacctc cgtctgatct acggctctgg cctgctgggc     2640

atgcagtctg gaagggggtc ccagcagtgg agtgccggga ccctcagagt ggagagagag     2700

acccgggatg tgtgtgctgt accccaagct gcccactgtc ttgcccgggc tgaggtcagc     2760

actgcagccc aaacagtgcc aacagccctg tccccacagg acctgggagc cctgggccag     2820

cacttctccc agtctccccg agtcacagtg ccgatcccac ccacccaccg tagggtgcac     2880

agcaaggcat cccagcttct ggcccgctcc tcactgagcc actacctggg catcagtctg     2940

gatctgcagc tgcagttgga gcagctccga gggaggacga ccatggccct ggacctgcca     3000

tcctcccact tgcagtgcag gatcccactg ctgccaaaga gatgggacaa ggaacctctc     3060

tctagcctca ggggcttctt tcctgccacc gtgcagcccc acaagcactg cctgaggccc     3120

atctgcttcc ccggctatgt gcccaactcc gcggtgctac agcagatgtg gctaaatgcg     3180

gagccagggg caagccagga tgccctgtgg ttgtggcgcc ccaggccatc ccaaacccag     3240

tggcagagga agctgctcca atggatgggg gagaagcctg gggaggaggg ggaggaagac     3300

aagaaggaag aggaggagga gaaggaagac gaggagctgg actgggcctt ggcttccctg     3360

agcccgcact ccaaccagca gctggattcc tgggaactgg aggatcagag tgctgtggac     3420

tggacccagg agccccggcg gcgcagctgc aaggttgcca ggacccaccc tcatccctgg     3480

caccgtcatg ggagtttgct cttggatgag cattacgggc atctgcccaa gtttctgcat     3540

ttcttcatct accagacctg gttcaaaaag ttgttcccca tcttcagcct gcaggcatac     3600

ccggaggcgg gcacgatcga gggcctggcc tcgctgttgg tggccctgct ggagaagacc     3660

acgtgggtcg accgtgtgca catcctgcag gtgctactga gactgctgcc caacatgagc     3720

agtgatctcc aaggccagct gcagggcctg ctcgtacact tgctcaacct ggaccagccc     3780

cccagcctcc aggaccagac acagaagaag ttcgtgatac tggcgctgca gctgctcctg     3840

gcctgctccc tggagtcccg ggatgtggtg ctggagctca tgtcctactt cctctactct     3900

cccgtgcact gccggccaga gctcaagaag ctgctgcacg ggctgggcct tcaggaccca     3960

gagggcttcc tattcaagga gatgatgacc tgggtccagg gcccagacct ggactccaag     4020

gccggcctgc gcacttgctg ccaccagaaa ctggaggaca tgatccagga gcttcaggag     4080

accccatcgc agacgtcagt ggtctctggg gcacccacac gcgcctccgt gataccctcg     4140

ggcacctcct ggtcggcctc cggcatcttc gggaggctct cgcaggtctc agaggtgcct     4200

ttgatggtgg tctcacctgc ggagccgcac tctttagccc cggagctcca ggcccagcgg     4260

atgctggcac ccaagcgcag ctgggggacc cctcagctcc gtctcagagt gctctccgag     4320

acgctgaaga gcttctgcct ggagcccgag gcccgcctgc accctgccgg gcctgctcag     4380

ctgcccggag agccgccgcc gctggaggag accgactggt cgcactcgca gctgctggac     4440

ttgggcccca tcgacgcgct caacttcttc tgtgagcagc tgcgggcgca gcagcggagt     4500

tcgctccagg agaaggctgc gcacccacac ccgccagagc cctacacggt ggcgccggtg     4560

cccgacatgg tggtgccacc tccgcgggag cactggtacc accccatcct ccggctgcag     4620

gaggccaagc cgcagaggtc cgcgaggtcc gcgatgagac tgaggggccc catgcggtcc     4680

cggctctgtg cgggccgcac cctggacggc cccatccgga cgctgaagct gccgttgccg     4740

cgtgtggagc cgcagccttt ccccctggac tggcctatgc ccccgcgccc gctgcccccg     4800

cggctcctgc agccggccct gcagcgctac tttctgccag cggacgcgga ccctgacacc     4860

tacagctga                                                             4869


<210>  384
<211>  1622
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Glu Ala Glu Val Trp Glu Ala Glu Gly Tyr Asn Leu Val Leu Asp 
1               5                   10                  15      


Ser Asp Leu Tyr Asp Ala Asp Gly Tyr Asp Val Pro Asp Pro Gly Leu 
            20                  25                  30          


Leu Thr Glu Lys Asn Glu Leu Thr Phe Thr Glu Pro Ser Gln Val Leu 
        35                  40                  45              


Pro Phe Leu Thr Ser Ser Gln Gln Trp Gln Ser Leu Thr Pro Arg Ala 
    50                  55                  60                  


Arg Ala Arg Arg Leu Trp Leu Leu Leu Arg Thr Ser Leu His Glu Val 
65                  70                  75                  80  


Val Glu Lys Glu Lys Arg Ala Glu Leu Arg Ala Ala Arg Leu Thr His 
                85                  90                  95      


Gly Leu Glu Pro Leu Arg Arg Leu Glu Val Ala Ala Gly Leu Arg Ser 
            100                 105                 110         


Val Ala Gln Asp Pro Val Gly Gly Arg Phe Val Val Leu Asp Gly Ala 
        115                 120                 125             


Gly Arg Leu His Leu His Lys Glu Asp Gly Trp Ala Gln Glu Thr Leu 
    130                 135                 140                 


Leu Ala Pro Val Arg Leu Thr Gly Leu Val Thr Val Leu Gly Pro Leu 
145                 150                 155                 160 


Gly Ala Val Gly Arg Phe Val Gly Trp Gly Pro Ala Gly Leu Ala Ile 
                165                 170                 175     


Leu Arg Pro Asn Leu Ser Leu Leu Trp Leu Ser Glu Gln Gly Val Gly 
            180                 185                 190         


Arg Ala Pro Gly Trp Ala Pro Thr Cys Cys Leu Pro Val Pro Asp Leu 
        195                 200                 205             


Arg Leu Leu Leu Val Ala Glu Met Asn Ser Ser Leu Ala Leu Trp Gln 
    210                 215                 220                 


Phe Arg Ser Gly Gly Arg Arg Leu Val Leu Arg Gly Ser Ala Leu His 
225                 230                 235                 240 


Pro Pro Pro Ser Pro Thr Gly Arg Leu Met Arg Leu Ala Val Ala Pro 
                245                 250                 255     


Val Pro Pro His His Val Leu Arg Cys Phe Ala Ala Tyr Gly Ser Ala 
            260                 265                 270         


Val Leu Thr Phe Asp Leu His Ala Trp Thr Leu Val Asp Val Arg Arg 
        275                 280                 285             


Asp Leu His Lys Thr Thr Ile Ser Asp Leu Ala Tyr Cys Glu Glu Val 
    290                 295                 300                 


Glu Ala Met Val Thr Ala Ser Arg Asp Ser Thr Val Lys Val Trp Glu 
305                 310                 315                 320 


Ala Asp Trp Gln Ile Arg Met Val Phe Val Gly His Thr Gly Pro Val 
                325                 330                 335     


Thr Ala Met Thr Val Leu Pro Asn Thr Thr Leu Val Leu Ser Ala Ser 
            340                 345                 350         


Gln Asp Gly Thr Leu Arg Thr Trp Asp Leu Gln Ala Ala Ala Gln Val 
        355                 360                 365             


Gly Glu Val Ala Leu Gly Phe Trp Gly Gln Asp Lys Leu Ser Arg Arg 
    370                 375                 380                 


Val Gly Arg Leu Leu Ala Pro Val Arg Pro Gly Trp Pro Val Leu Ser 
385                 390                 395                 400 


Leu Cys Ala Ser Ser Met Gln Leu Trp Arg Val Arg Glu Leu Tyr Ser 
                405                 410                 415     


Pro Leu Ala Gln Leu Pro Ala Lys Val Leu His Val Gln Val Ala Pro 
            420                 425                 430         


Ala Leu Pro Ala Pro Ala His Gln Ser Leu Pro Thr Arg Leu Val Cys 
        435                 440                 445             


Ala Cys Ala Asp Gly Ser Val Tyr Leu Leu Ser Ala Ala Thr Gly Arg 
    450                 455                 460                 


Ile Val Ser Ser Leu Leu Leu Glu Pro Glu Asp Cys Ala Ala Ala Val 
465                 470                 475                 480 


Ala Tyr Cys Leu Pro Arg Glu Ala Leu Trp Leu Leu Thr Arg Ala Gly 
                485                 490                 495     


His Leu Val Arg Ala Asn Ala Ala Arg Cys Pro Met Ser Val Leu His 
            500                 505                 510         


Arg Val Cys Pro Pro Pro Pro Pro Ala Pro Gln Pro Cys Cys Leu His 
        515                 520                 525             


Leu Tyr Ser His Leu Thr Asp Leu Glu Gly Ala Phe Ser Ser Trp Glu 
    530                 535                 540                 


Ile Val Arg Gln His Trp Gly Glu Leu Arg Cys Ser Ser Val Ala Cys 
545                 550                 555                 560 


Ala Trp Lys Asn Lys Asn Arg Tyr Leu Pro Val Val Gly His Thr Asp 
                565                 570                 575     


Gly Thr Leu Ser Val Leu Glu Trp Leu Ser Ser Lys Thr Val Phe Gln 
            580                 585                 590         


Thr Glu Ala His Ser Pro Gly Pro Val Val Ala Ile Ala Ser Thr Trp 
        595                 600                 605             


Asn Ser Ile Val Ser Ser Gly Gly Asp Leu Thr Val Lys Met Trp Arg 
    610                 615                 620                 


Val Phe Pro Tyr Ala Glu Glu Ser Leu Ser Leu Leu Arg Thr Phe Ser 
625                 630                 635                 640 


Cys Cys Tyr Pro Ala Val Ala Leu Cys Ala Leu Gly Arg Arg Val Thr 
                645                 650                 655     


Ala Gly Phe Glu Asp Pro Asp Ser Ala Thr Tyr Gly Leu Val Gln Phe 
            660                 665                 670         


Gly Leu Gly Asp Ser Pro Arg Leu Asp His Arg Pro Gln Asp Asp Pro 
        675                 680                 685             


Thr Asp His Ile Thr Gly Leu Cys Cys Cys Pro Thr Leu Lys Leu Tyr 
    690                 695                 700                 


Ala Cys Ser Ser Leu Asp Cys Thr Val Arg Ile Trp Thr Ala Glu Asn 
705                 710                 715                 720 


Arg Leu Leu Arg Leu Leu Gln Leu Asn Gly Ala Pro Gln Ala Leu Ala 
                725                 730                 735     


Phe Cys Ser Asn Ser Gly Asp Leu Val Leu Ala Leu Gly Ser Arg Leu 
            740                 745                 750         


Cys Leu Val Ser His Arg Leu Tyr Leu Pro Thr Ser Tyr Leu Val Lys 
        755                 760                 765             


Lys Met Cys Arg Lys Ala Pro Asp Val Val Asp Asp Pro Pro Leu Pro 
    770                 775                 780                 


Leu Met Ser Gln Glu Ser Leu Thr Ser Ala Gln Leu Gln Arg Leu Thr 
785                 790                 795                 800 


Asn Leu His Gly Ala Ala Ser Leu Ser Glu Ala Leu Ser Leu Ile His 
                805                 810                 815     


Arg Arg Arg Ala Thr Ser Gln His Leu Val Pro Lys Glu Asp Leu Asp 
            820                 825                 830         


Ala Ile Val Ala Arg Asp Arg Asp Leu Gln Gln Leu Arg Leu Gly Leu 
        835                 840                 845             


Val Val Pro Ala Ala Gln Pro Pro Pro Ser Trp Gln Gln Arg Gln Glu 
    850                 855                 860                 


Gly Phe Asp Asn Tyr Leu Arg Leu Ile Tyr Gly Ser Gly Leu Leu Gly 
865                 870                 875                 880 


Met Gln Ser Gly Arg Gly Ser Gln Gln Trp Ser Ala Gly Thr Leu Arg 
                885                 890                 895     


Val Glu Arg Glu Thr Arg Asp Val Cys Ala Val Pro Gln Ala Ala His 
            900                 905                 910         


Cys Leu Ala Arg Ala Glu Val Ser Thr Ala Ala Gln Thr Val Pro Thr 
        915                 920                 925             


Ala Leu Ser Pro Gln Asp Leu Gly Ala Leu Gly Gln His Phe Ser Gln 
    930                 935                 940                 


Ser Pro Arg Val Thr Val Pro Ile Pro Pro Thr His Arg Arg Val His 
945                 950                 955                 960 


Ser Lys Ala Ser Gln Leu Leu Ala Arg Ser Ser Leu Ser His Tyr Leu 
                965                 970                 975     


Gly Ile Ser Leu Asp Leu Gln Leu Gln Leu Glu Gln Leu Arg Gly Arg 
            980                 985                 990         


Thr Thr Met Ala Leu Asp Leu Pro  Ser Ser His Leu Gln  Cys Arg Ile 
        995                 1000                 1005             


Pro Leu  Leu Pro Lys Arg Trp  Asp Lys Glu Pro Leu  Ser Ser Leu 
    1010                 1015                 1020             


Arg Gly  Phe Phe Pro Ala Thr  Val Gln Pro His Lys  His Cys Leu 
    1025                 1030                 1035             


Arg Pro  Ile Cys Phe Pro Gly  Tyr Val Pro Asn Ser  Ala Val Leu 
    1040                 1045                 1050             


Gln Gln  Met Trp Leu Asn Ala  Glu Pro Gly Ala Ser  Gln Asp Ala 
    1055                 1060                 1065             


Leu Trp  Leu Trp Arg Pro Arg  Pro Ser Gln Thr Gln  Trp Gln Arg 
    1070                 1075                 1080             


Lys Leu  Leu Gln Trp Met Gly  Glu Lys Pro Gly Glu  Glu Gly Glu 
    1085                 1090                 1095             


Glu Asp  Lys Lys Glu Glu Glu  Glu Glu Lys Glu Asp  Glu Glu Leu 
    1100                 1105                 1110             


Asp Trp  Ala Leu Ala Ser Leu  Ser Pro His Ser Asn  Gln Gln Leu 
    1115                 1120                 1125             


Asp Ser  Trp Glu Leu Glu Asp  Gln Ser Ala Val Asp  Trp Thr Gln 
    1130                 1135                 1140             


Glu Pro  Arg Arg Arg Ser Cys  Lys Val Ala Arg Thr  His Pro His 
    1145                 1150                 1155             


Pro Trp  His Arg His Gly Ser  Leu Leu Leu Asp Glu  His Tyr Gly 
    1160                 1165                 1170             


His Leu  Pro Lys Phe Leu His  Phe Phe Ile Tyr Gln  Thr Trp Phe 
    1175                 1180                 1185             


Lys Lys  Leu Phe Pro Ile Phe  Ser Leu Gln Ala Tyr  Pro Glu Ala 
    1190                 1195                 1200             


Gly Thr  Ile Glu Gly Leu Ala  Ser Leu Leu Val Ala  Leu Leu Glu 
    1205                 1210                 1215             


Lys Thr  Thr Trp Val Asp Arg  Val His Ile Leu Gln  Val Leu Leu 
    1220                 1225                 1230             


Arg Leu  Leu Pro Asn Met Ser  Ser Asp Leu Gln Gly  Gln Leu Gln 
    1235                 1240                 1245             


Gly Leu  Leu Val His Leu Leu  Asn Leu Asp Gln Pro  Pro Ser Leu 
    1250                 1255                 1260             


Gln Asp  Gln Thr Gln Lys Lys  Phe Val Ile Leu Ala  Leu Gln Leu 
    1265                 1270                 1275             


Leu Leu  Ala Cys Ser Leu Glu  Ser Arg Asp Val Val  Leu Glu Leu 
    1280                 1285                 1290             


Met Ser  Tyr Phe Leu Tyr Ser  Pro Val His Cys Arg  Pro Glu Leu 
    1295                 1300                 1305             


Lys Lys  Leu Leu His Gly Leu  Gly Leu Gln Asp Pro  Glu Gly Phe 
    1310                 1315                 1320             


Leu Phe  Lys Glu Met Met Thr  Trp Val Gln Gly Pro  Asp Leu Asp 
    1325                 1330                 1335             


Ser Lys  Ala Gly Leu Arg Thr  Cys Cys His Gln Lys  Leu Glu Asp 
    1340                 1345                 1350             


Met Ile  Gln Glu Leu Gln Glu  Thr Pro Ser Gln Thr  Ser Val Val 
    1355                 1360                 1365             


Ser Gly  Ala Pro Thr Arg Ala  Ser Val Ile Pro Ser  Gly Thr Ser 
    1370                 1375                 1380             


Trp Ser  Ala Ser Gly Ile Phe  Gly Arg Leu Ser Gln  Val Ser Glu 
    1385                 1390                 1395             


Val Pro  Leu Met Val Val Ser  Pro Ala Glu Pro His  Ser Leu Ala 
    1400                 1405                 1410             


Pro Glu  Leu Gln Ala Gln Arg  Met Leu Ala Pro Lys  Arg Ser Trp 
    1415                 1420                 1425             


Gly Thr  Pro Gln Leu Arg Leu  Arg Val Leu Ser Glu  Thr Leu Lys 
    1430                 1435                 1440             


Ser Phe  Cys Leu Glu Pro Glu  Ala Arg Leu His Pro  Ala Gly Pro 
    1445                 1450                 1455             


Ala Gln  Leu Pro Gly Glu Pro  Pro Pro Leu Glu Glu  Thr Asp Trp 
    1460                 1465                 1470             


Ser His  Ser Gln Leu Leu Asp  Leu Gly Pro Ile Asp  Ala Leu Asn 
    1475                 1480                 1485             


Phe Phe  Cys Glu Gln Leu Arg  Ala Gln Gln Arg Ser  Ser Leu Gln 
    1490                 1495                 1500             


Glu Lys  Ala Ala His Pro His  Pro Pro Glu Pro Tyr  Thr Val Ala 
    1505                 1510                 1515             


Pro Val  Pro Asp Met Val Val  Pro Pro Pro Arg Glu  His Trp Tyr 
    1520                 1525                 1530             


His Pro  Ile Leu Arg Leu Gln  Glu Ala Lys Pro Gln  Arg Ser Ala 
    1535                 1540                 1545             


Arg Ser  Ala Met Arg Leu Arg  Gly Pro Met Arg Ser  Arg Leu Cys 
    1550                 1555                 1560             


Ala Gly  Arg Thr Leu Asp Gly  Pro Ile Arg Thr Leu  Lys Leu Pro 
    1565                 1570                 1575             


Leu Pro  Arg Val Glu Pro Gln  Pro Phe Pro Leu Asp  Trp Pro Met 
    1580                 1585                 1590             


Pro Pro  Arg Pro Leu Pro Pro  Arg Leu Leu Gln Pro  Ala Leu Gln 
    1595                 1600                 1605             


Arg Tyr  Phe Leu Pro Ala Asp  Ala Asp Pro Asp Thr  Tyr Ser 
    1610                 1615                 1620         


<210>  385
<211>  4335
<212>  DNA
<213>  Homo sapiens

<400>  385
atgaagaaca agggtgctaa gcagaagctg aaacgaaagg gagccgccag cgcgtttggc       60

tgtgacctga cggagtatct ggaaagctcg ggacaggatg ttccatacgt tttgaagagc      120

tgtgcagaat ttatagagac tcacggcatc gtggatggaa tctatcggct ttcaggagtc      180

acctcaaaca tacaacggct aaggcaagag tttggctcag atcaatgtcc agatctgaca      240

agggaagtgt acctccagga catccactgt gtgggctcgc tttgcaagct ctactttagg      300

gagctgccca accccctcct gacttatgag ctctatgaga aattcacgga ggcagtgtcg      360

cattgccctg aagaaggcca actggcccga atccaaaatg ttatccagga gcttcctcca      420

tcccactata ggaccttgga atacctgatt cgacacctgg cccatatcgc ctccttcagc      480

agcaagacca acatgcacgc ccggaacctg gccctggtgt gggcgccaaa cctcctcagg      540

tctaaagaaa ttgaagccac tggttgcaat ggagatgcag ccttccttgc agtccgggtc      600

cagcaggtgg tgattgagtt catattgaat catgtagatc aaatctttaa caacggtgca      660

cctgggtctc tggagaatga tgaaaaccgg cccatcatga agagcctgac cttgccagcc      720

ctctccctgc ccatgaagct ggtgagcctt gaggaagctc aagcccgcag cctggccact      780

aaccatcctg ctcgcaagga aaggagggag aacagcctgc ctgagattgt ccctcccatg      840

ggcaccctct tccacactgt ccttgagtta ccagacaaca agcgaaagct ctccagtaaa      900

tcaaagaagt ggaaatcaat atttaacctg ggacgttctg gatcagactc caaatcaaaa      960

ctgagtagaa atgggagtgt atttgtgaga ggacagaggc tctcggtgga aaaggctact     1020

atccgaccag ctaaaagcat ggactcacta tgttcagtgc ctgtagaagg aaaagaaacc     1080

aagggaaatt tcaatcgaac agttaccacc ggtggatttt tcattccagc aacaaagatg     1140

cactccaccg gcaccggcag ctcatgtgac ctcaccaagc aggagggcga atggggccag     1200

gaggggatgc ctcccggggc tgagggtggc tttgatgtga gcagtgatcg cagccatctc     1260

cagggcgctc aggcccggcc cccaccggaa cagctgaagg ttttccggcc tgttgaggat     1320

ccggagagcg agcaaacagc cccaaagatg ttgggtatgt tctacacttc gaacgacagc     1380

cctagcaaat ccgtcttcac cagcagcctc ttccagatgg agccctcgcc gcgtaaccag     1440

cgcaaggcgc tgaacatctc cgagcccttt gcggtatctg tgccgctccg cgtgtccgca     1500

gtcatcagca ccaacagcac gccgtgcaga acacccccga aggagctgca gtctctttcc     1560

agcctggaag agttttcttt tcatggatca gagagcggag gctggccaga agaagagaaa     1620

ccgctgggag ctgagacttc tgcagcttct gtacctaaga aggcaggtct tgaggatgcc     1680

aaggcagtac ctgaagcacc ggggacagtg gaatgcagca aaggcctgtc ccaggagcca     1740

ggcgcccacc tggaggagaa gaaaacccca gaaagctcct tgagctctca acatttaaat     1800

gaattagaga agaggccaaa tccggagaag gtggtggagg agggacgaga ggctggtgag     1860

atggagtcca gcaccctgca ggagagcccc agggccagag ccgaagctgt gcttctccat     1920

gagatggatg aagatgatct ggccaatgcc ctgatctggc ctgagattca acaggagctg     1980

aaaatcattg aatctgagga ggagctctca tcgttgccac ctcctgctct gaagaccagc     2040

ccaattcagc ctattctcga gtcgagtctg gggcccttta ttccctcaga gcctcctggg     2100

agcttgcctt gtggctcctt ccctgctcca gtctccaccc ctctggaggt gtggactagg     2160

gatccagcca atcagagcac acagggggct tccacagcag ccagcagaga gaagccggaa     2220

cctgagcagg gcctgcaccc agacctcgcc agcctggctc ctctggaaat agttcctttt     2280

gagaaggcat ctccacaagc aacagtggaa gtaggaggcc caggcaatct gtctcctcca     2340

ctcccacctg ctcctccccc tccaactcct ctggaggagt caactccagt cctgctttca     2400

aagggcggcc cggaaagaga agactcatcc aggaaattga ggacagatct ctacatagac     2460

cagctgaagt cccaagacag ccctgagatc tctagcctct gtcagggaga ggaggcaacc     2520

ccaagacaca gtgacaagca aaattcaaag aatgctgctt ctgaggggaa aggctgtggt     2580

tttccaagcc caaccaggga ggttgagatc gtctcacaag aagaggagga tgtaacccat     2640

tcagtacagg agccttcaga ctgtgacgaa gatgacactg tgacagacat tgcccagcat     2700

ggcctggaga tggtggagcc ctgggaggaa ccccagtggg tgacgagtcc ccttcactct     2760

cccaccctga aagacgcgca caaggcccag gtacagggcc ttcagggtca ccagttggag     2820

aagaggcttt cccacaggcc cagccttcgc cagagccatt ctctagatag caaacccacg     2880

gttaaaagcc agtggactct cgaggttccc tcctccagca gctgtgctaa tcttgaaaca     2940

gagaggaatt ctgaccctct tcagccccag gcacccagga gagagattac tggatgggat     3000

gagaaagccc tgaggtcctt cagagagttc tctggcctga aaggggcaga ggctcctccc     3060

aaccagaagg gaccaagtgg tgtgcaaccc aacccagcag aaaccagccc catcagccta     3120

gcagagggaa aggagctagg gacacacctg gggcacagca gtccacagat taggcaaggt     3180

ggtgttcctg ggccagagag cagcaaggag agttcaccca gcgtgcagga cagcacttcg     3240

cctggagagc accccgcaaa gttacagcta aagagcacag agtgtgggcc cccaaaaggg     3300

aaaaacaggc cttcttccct caacttggac cctgccattc ccattgctga cctcttctgg     3360

tttgagaatg tggcctcatt tagttcacct ggaatgcagg tctctgagcc aggagaccca     3420

aaggtcacat ggatgacctc atcttactgt aaagcagacc cctggagggt ttactcccag     3480

gacccccagg acctggacat tgttgctcat gcactgacag gccgccgtaa ctcagctcct     3540

gtgagtgtgt cagctgtgag aacctccttc atggtcaaaa tgtgccaggc cagggcggtc     3600

ccagtcatcc ctcccaagat tcagtacacc cagatcccac agcccctgcc ctctcagagc     3660

tcaggggaga atggggttca gcctctggag aggagccagg agggacccag ctcaaccagt     3720

gggaccactc agaaacctgc caaagatgat tctccctcct ccctggaaag ctcaaaggaa     3780

gaaaaaccaa agcaagatcc cggagccatt aagtcctcac cagtggatgc cactgcaccc     3840

tgcatgtgcg agggacctac cctttctcca gaaccaggct cgtctaacct gctctccacc     3900

caggatgcag tagtgcaatg cagaaagcgc atgtcagaga cagagccatc tggggacaac     3960

cttctttctt caaaactaga gcgaccatct gggggttcta agcctttcca caggtcaagg     4020

ccaggaagac ctcagagcct aatcttattc agtcctcctt tccccattat ggaccacctg     4080

cccccttcat ccacagtgac agattccaag gtcctgctgt cccctatcag aagtcccacc     4140

cagacagttt cccctggcct tctttgtgga gagttggcag aaaacacatg ggtcacacca     4200

gaaggggtta cacttaggaa taaaatgacc atccctaaga atggccagag actagagacc     4260

tcaaccagct gtttttacca gcctcagcgg agatcagtaa ttctggatgg aagaagtggg     4320

aggcaaatag aatga                                                      4335


<210>  386
<211>  1444
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Lys Asn Lys Gly Ala Lys Gln Lys Leu Lys Arg Lys Gly Ala Ala 
1               5                   10                  15      


Ser Ala Phe Gly Cys Asp Leu Thr Glu Tyr Leu Glu Ser Ser Gly Gln 
            20                  25                  30          


Asp Val Pro Tyr Val Leu Lys Ser Cys Ala Glu Phe Ile Glu Thr His 
        35                  40                  45              


Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Thr Ser Asn Ile 
    50                  55                  60                  


Gln Arg Leu Arg Gln Glu Phe Gly Ser Asp Gln Cys Pro Asp Leu Thr 
65                  70                  75                  80  


Arg Glu Val Tyr Leu Gln Asp Ile His Cys Val Gly Ser Leu Cys Lys 
                85                  90                  95      


Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Glu Leu Tyr 
            100                 105                 110         


Glu Lys Phe Thr Glu Ala Val Ser His Cys Pro Glu Glu Gly Gln Leu 
        115                 120                 125             


Ala Arg Ile Gln Asn Val Ile Gln Glu Leu Pro Pro Ser His Tyr Arg 
    130                 135                 140                 


Thr Leu Glu Tyr Leu Ile Arg His Leu Ala His Ile Ala Ser Phe Ser 
145                 150                 155                 160 


Ser Lys Thr Asn Met His Ala Arg Asn Leu Ala Leu Val Trp Ala Pro 
                165                 170                 175     


Asn Leu Leu Arg Ser Lys Glu Ile Glu Ala Thr Gly Cys Asn Gly Asp 
            180                 185                 190         


Ala Ala Phe Leu Ala Val Arg Val Gln Gln Val Val Ile Glu Phe Ile 
        195                 200                 205             


Leu Asn His Val Asp Gln Ile Phe Asn Asn Gly Ala Pro Gly Ser Leu 
    210                 215                 220                 


Glu Asn Asp Glu Asn Arg Pro Ile Met Lys Ser Leu Thr Leu Pro Ala 
225                 230                 235                 240 


Leu Ser Leu Pro Met Lys Leu Val Ser Leu Glu Glu Ala Gln Ala Arg 
                245                 250                 255     


Ser Leu Ala Thr Asn His Pro Ala Arg Lys Glu Arg Arg Glu Asn Ser 
            260                 265                 270         


Leu Pro Glu Ile Val Pro Pro Met Gly Thr Leu Phe His Thr Val Leu 
        275                 280                 285             


Glu Leu Pro Asp Asn Lys Arg Lys Leu Ser Ser Lys Ser Lys Lys Trp 
    290                 295                 300                 


Lys Ser Ile Phe Asn Leu Gly Arg Ser Gly Ser Asp Ser Lys Ser Lys 
305                 310                 315                 320 


Leu Ser Arg Asn Gly Ser Val Phe Val Arg Gly Gln Arg Leu Ser Val 
                325                 330                 335     


Glu Lys Ala Thr Ile Arg Pro Ala Lys Ser Met Asp Ser Leu Cys Ser 
            340                 345                 350         


Val Pro Val Glu Gly Lys Glu Thr Lys Gly Asn Phe Asn Arg Thr Val 
        355                 360                 365             


Thr Thr Gly Gly Phe Phe Ile Pro Ala Thr Lys Met His Ser Thr Gly 
    370                 375                 380                 


Thr Gly Ser Ser Cys Asp Leu Thr Lys Gln Glu Gly Glu Trp Gly Gln 
385                 390                 395                 400 


Glu Gly Met Pro Pro Gly Ala Glu Gly Gly Phe Asp Val Ser Ser Asp 
                405                 410                 415     


Arg Ser His Leu Gln Gly Ala Gln Ala Arg Pro Pro Pro Glu Gln Leu 
            420                 425                 430         


Lys Val Phe Arg Pro Val Glu Asp Pro Glu Ser Glu Gln Thr Ala Pro 
        435                 440                 445             


Lys Met Leu Gly Met Phe Tyr Thr Ser Asn Asp Ser Pro Ser Lys Ser 
    450                 455                 460                 


Val Phe Thr Ser Ser Leu Phe Gln Met Glu Pro Ser Pro Arg Asn Gln 
465                 470                 475                 480 


Arg Lys Ala Leu Asn Ile Ser Glu Pro Phe Ala Val Ser Val Pro Leu 
                485                 490                 495     


Arg Val Ser Ala Val Ile Ser Thr Asn Ser Thr Pro Cys Arg Thr Pro 
            500                 505                 510         


Pro Lys Glu Leu Gln Ser Leu Ser Ser Leu Glu Glu Phe Ser Phe His 
        515                 520                 525             


Gly Ser Glu Ser Gly Gly Trp Pro Glu Glu Glu Lys Pro Leu Gly Ala 
    530                 535                 540                 


Glu Thr Ser Ala Ala Ser Val Pro Lys Lys Ala Gly Leu Glu Asp Ala 
545                 550                 555                 560 


Lys Ala Val Pro Glu Ala Pro Gly Thr Val Glu Cys Ser Lys Gly Leu 
                565                 570                 575     


Ser Gln Glu Pro Gly Ala His Leu Glu Glu Lys Lys Thr Pro Glu Ser 
            580                 585                 590         


Ser Leu Ser Ser Gln His Leu Asn Glu Leu Glu Lys Arg Pro Asn Pro 
        595                 600                 605             


Glu Lys Val Val Glu Glu Gly Arg Glu Ala Gly Glu Met Glu Ser Ser 
    610                 615                 620                 


Thr Leu Gln Glu Ser Pro Arg Ala Arg Ala Glu Ala Val Leu Leu His 
625                 630                 635                 640 


Glu Met Asp Glu Asp Asp Leu Ala Asn Ala Leu Ile Trp Pro Glu Ile 
                645                 650                 655     


Gln Gln Glu Leu Lys Ile Ile Glu Ser Glu Glu Glu Leu Ser Ser Leu 
            660                 665                 670         


Pro Pro Pro Ala Leu Lys Thr Ser Pro Ile Gln Pro Ile Leu Glu Ser 
        675                 680                 685             


Ser Leu Gly Pro Phe Ile Pro Ser Glu Pro Pro Gly Ser Leu Pro Cys 
    690                 695                 700                 


Gly Ser Phe Pro Ala Pro Val Ser Thr Pro Leu Glu Val Trp Thr Arg 
705                 710                 715                 720 


Asp Pro Ala Asn Gln Ser Thr Gln Gly Ala Ser Thr Ala Ala Ser Arg 
                725                 730                 735     


Glu Lys Pro Glu Pro Glu Gln Gly Leu His Pro Asp Leu Ala Ser Leu 
            740                 745                 750         


Ala Pro Leu Glu Ile Val Pro Phe Glu Lys Ala Ser Pro Gln Ala Thr 
        755                 760                 765             


Val Glu Val Gly Gly Pro Gly Asn Leu Ser Pro Pro Leu Pro Pro Ala 
    770                 775                 780                 


Pro Pro Pro Pro Thr Pro Leu Glu Glu Ser Thr Pro Val Leu Leu Ser 
785                 790                 795                 800 


Lys Gly Gly Pro Glu Arg Glu Asp Ser Ser Arg Lys Leu Arg Thr Asp 
                805                 810                 815     


Leu Tyr Ile Asp Gln Leu Lys Ser Gln Asp Ser Pro Glu Ile Ser Ser 
            820                 825                 830         


Leu Cys Gln Gly Glu Glu Ala Thr Pro Arg His Ser Asp Lys Gln Asn 
        835                 840                 845             


Ser Lys Asn Ala Ala Ser Glu Gly Lys Gly Cys Gly Phe Pro Ser Pro 
    850                 855                 860                 


Thr Arg Glu Val Glu Ile Val Ser Gln Glu Glu Glu Asp Val Thr His 
865                 870                 875                 880 


Ser Val Gln Glu Pro Ser Asp Cys Asp Glu Asp Asp Thr Val Thr Asp 
                885                 890                 895     


Ile Ala Gln His Gly Leu Glu Met Val Glu Pro Trp Glu Glu Pro Gln 
            900                 905                 910         


Trp Val Thr Ser Pro Leu His Ser Pro Thr Leu Lys Asp Ala His Lys 
        915                 920                 925             


Ala Gln Val Gln Gly Leu Gln Gly His Gln Leu Glu Lys Arg Leu Ser 
    930                 935                 940                 


His Arg Pro Ser Leu Arg Gln Ser His Ser Leu Asp Ser Lys Pro Thr 
945                 950                 955                 960 


Val Lys Ser Gln Trp Thr Leu Glu Val Pro Ser Ser Ser Ser Cys Ala 
                965                 970                 975     


Asn Leu Glu Thr Glu Arg Asn Ser Asp Pro Leu Gln Pro Gln Ala Pro 
            980                 985                 990         


Arg Arg Glu Ile Thr Gly Trp Asp  Glu Lys Ala Leu Arg  Ser Phe Arg 
        995                 1000                 1005             


Glu Phe  Ser Gly Leu Lys Gly  Ala Glu Ala Pro Pro  Asn Gln Lys 
    1010                 1015                 1020             


Gly Pro  Ser Gly Val Gln Pro  Asn Pro Ala Glu Thr  Ser Pro Ile 
    1025                 1030                 1035             


Ser Leu  Ala Glu Gly Lys Glu  Leu Gly Thr His Leu  Gly His Ser 
    1040                 1045                 1050             


Ser Pro  Gln Ile Arg Gln Gly  Gly Val Pro Gly Pro  Glu Ser Ser 
    1055                 1060                 1065             


Lys Glu  Ser Ser Pro Ser Val  Gln Asp Ser Thr Ser  Pro Gly Glu 
    1070                 1075                 1080             


His Pro  Ala Lys Leu Gln Leu  Lys Ser Thr Glu Cys  Gly Pro Pro 
    1085                 1090                 1095             


Lys Gly  Lys Asn Arg Pro Ser  Ser Leu Asn Leu Asp  Pro Ala Ile 
    1100                 1105                 1110             


Pro Ile  Ala Asp Leu Phe Trp  Phe Glu Asn Val Ala  Ser Phe Ser 
    1115                 1120                 1125             


Ser Pro  Gly Met Gln Val Ser  Glu Pro Gly Asp Pro  Lys Val Thr 
    1130                 1135                 1140             


Trp Met  Thr Ser Ser Tyr Cys  Lys Ala Asp Pro Trp  Arg Val Tyr 
    1145                 1150                 1155             


Ser Gln  Asp Pro Gln Asp Leu  Asp Ile Val Ala His  Ala Leu Thr 
    1160                 1165                 1170             


Gly Arg  Arg Asn Ser Ala Pro  Val Ser Val Ser Ala  Val Arg Thr 
    1175                 1180                 1185             


Ser Phe  Met Val Lys Met Cys  Gln Ala Arg Ala Val  Pro Val Ile 
    1190                 1195                 1200             


Pro Pro  Lys Ile Gln Tyr Thr  Gln Ile Pro Gln Pro  Leu Pro Ser 
    1205                 1210                 1215             


Gln Ser  Ser Gly Glu Asn Gly  Val Gln Pro Leu Glu  Arg Ser Gln 
    1220                 1225                 1230             


Glu Gly  Pro Ser Ser Thr Ser  Gly Thr Thr Gln Lys  Pro Ala Lys 
    1235                 1240                 1245             


Asp Asp  Ser Pro Ser Ser Leu  Glu Ser Ser Lys Glu  Glu Lys Pro 
    1250                 1255                 1260             


Lys Gln  Asp Pro Gly Ala Ile  Lys Ser Ser Pro Val  Asp Ala Thr 
    1265                 1270                 1275             


Ala Pro  Cys Met Cys Glu Gly  Pro Thr Leu Ser Pro  Glu Pro Gly 
    1280                 1285                 1290             


Ser Ser  Asn Leu Leu Ser Thr  Gln Asp Ala Val Val  Gln Cys Arg 
    1295                 1300                 1305             


Lys Arg  Met Ser Glu Thr Glu  Pro Ser Gly Asp Asn  Leu Leu Ser 
    1310                 1315                 1320             


Ser Lys  Leu Glu Arg Pro Ser  Gly Gly Ser Lys Pro  Phe His Arg 
    1325                 1330                 1335             


Ser Arg  Pro Gly Arg Pro Gln  Ser Leu Ile Leu Phe  Ser Pro Pro 
    1340                 1345                 1350             


Phe Pro  Ile Met Asp His Leu  Pro Pro Ser Ser Thr  Val Thr Asp 
    1355                 1360                 1365             


Ser Lys  Val Leu Leu Ser Pro  Ile Arg Ser Pro Thr  Gln Thr Val 
    1370                 1375                 1380             


Ser Pro  Gly Leu Leu Cys Gly  Glu Leu Ala Glu Asn  Thr Trp Val 
    1385                 1390                 1395             


Thr Pro  Glu Gly Val Thr Leu  Arg Asn Lys Met Thr  Ile Pro Lys 
    1400                 1405                 1410             


Asn Gly  Gln Arg Leu Glu Thr  Ser Thr Ser Cys Phe  Tyr Gln Pro 
    1415                 1420                 1425             


Gln Arg  Arg Ser Val Ile Leu  Asp Gly Arg Ser Gly  Arg Gln Ile 
    1430                 1435                 1440             


Glu 
    


<210>  387
<211>  9369
<212>  DNA
<213>  Homo sapiens

<400>  387
atgccgggag ccgccggggt cctcctcctt ctgctgctct ccggaggcct cgggggcgta       60

caggcgcagc ggccgcagca gcagcggcag tcacaggcac atcagcaaag aggtttattc      120

cctgctgtcc tgaatcttgc ttctaatgct cttatcacga ccaatgcaac atgtggagaa      180

aaaggacctg aaatgtactg caaattggta gaacatgtcc ctgggcagcc tgtgaggaac      240

ccgcagtgtc gaatctgcaa tcaaaacagc agcaatccaa accagagaca cccgattaca      300

aatgctattg atggaaagaa cacttggtgg cagagtccca gtattaagaa tggaatcgaa      360

taccattatg tgacaattac cctggattta cagcaggtgt tccagatcgc gtatgtgatt      420

gtgaaggcag ctaactcccc ccggcctgga aactggattt tggaacgctc tcttgatgat      480

gttgaataca agccctggca gtatcatgct gtgacagaca cggagtgcct aacgctttac      540

aatatttatc cccgcactgg gccaccgtca tatgccaaag atgatgaggt catctgcact      600

tcattttact ccaagataca ccccttagaa aatggagaga ttcacatctc tttaatcaat      660

gggagaccaa gtgccgatga tccttctcca gaactgctag aatttacctc cgctcgctat      720

attcgcctga gatttcagag gatccgcaca ctgaatgctg acttgatgat gtttgctcac      780

aaagacccaa gagaaattga ccccattgtc accagaagat attactactc ggtcaaggat      840

atttcagttg gagggatgtg catctgctat ggtcatgcca gggcttgtcc acttgatcca      900

gcgacaaata aatctcgctg tgagtgtgag cataacacat gtggcgatag ctgtgatcag      960

tgctgtccag gattccatca gaaaccctgg agagctggaa cttttctaac taaaactgaa     1020

tgtgaagcat gcaattgtca tggaaaagct gaagaatgct attatgatga aaatgttgcc     1080

agaagaaatc tgagtttgaa tatacgtgga aagtacattg gagggggtgt ctgcattaat     1140

tgtacccaaa acactgctgg tataaactgc gagacatgta ctgatggctt cttcagaccc     1200

aaaggggtat ctccaaatta tccaaggcca tgccagccat gtcattgcga tccaattggt     1260

tccttaaatg aagtctgtgt caaggatgag aaacatgctc gacgaggttt ggcacctgga     1320

tcctgtcatt gcaaaactgg ttttggaggt gtgagctgtg atcggtgtgc caggggctac     1380

actggctacc cggactgcaa agcctgtaac tgcagtgggt tagggagcaa aaatgaggat     1440

ccttgttttg gcccctgtat ctgcaaggaa aatgttgaag gaggagactg tagtcgttgc     1500

aaatccggct tcttcaattt gcaagaggat aattggaaag gctgcgatga gtgtttctgt     1560

tcaggggttt caaacagatg tcagagttcc tactggacct atggcaaaat acaagatatg     1620

agtggctggt atctgactga ccttcctggc cgcattcgag tggctcccca gcaggacgac     1680

ttggactcac ctcagcagat cagcatcagt aacgcggagg cccggcaagc cctgccgcac     1740

agctactact ggagcgcgcc ggctccctat ctgggaaaca aactcccagc agtaggagga     1800

cagttgacat ttaccatatc atatgacctt gaagaagagg aagaagatac agaacgtgtt     1860

ctccagctta tgattatctt agagggtaat gacttgagca tcagcacagc ccaagatgag     1920

gtgtacctgc acccatctga agaacatact aatgtattgt tacttaaaga agaatcattt     1980

accatacatg gcacacattt tccagtccgt agaaaggaat ttatgacagt gcttgcgaat     2040

ttgaagagag tcctcctaca aatcacatac agctttggga tggatgccat cttcaggttg     2100

agctctgtta accttgaatc cgctgtctcc tatcctactg atggaagcat tgcagcagct     2160

gtagaagtgt gtcagtgccc accagggtat actggctcct cttgtgaatc ttgttggcct     2220

aggcacaggc gagttaacgg cactattttt ggtggcatct gtgagccatg tcagtgcttt     2280

ggtcatgcgg agtcctgtga tgacgtcact ggagaatgcc tgaactgtaa ggatcacaca     2340

ggtggcccat attgtgataa atgtcttcct ggtttctatg gcgagcctac taaaggaacc     2400

tctgaagact gtcaaccctg tgcctgtcca ctcaatatcc catccaataa ctttagccca     2460

acgtgccatt tagaccggag tcttggattg atctgtgatg gatgccctgt cgggtacaca     2520

ggaccacgct gtgagaggtg tgcagaaggc tattttggac aaccctctgt acctggagga     2580

tcatgtcagc catgccaatg caatgacaac cttgacttct ccatccctgg cagctgtgac     2640

agcttgtctg gctcctgtct gatatgtaaa ccaggtacaa caggccggta ctgtgagctc     2700

tgtgctgatg gatattttgg agatgcagtt gatgcgaaga actgtcagcc ctgtcgctgt     2760

aatgccggtg gctctttctc tgaggtttgc cacagtcaaa ctggacagtg tgagtgcaga     2820

gccaacgttc agggtcagag atgtgacaaa tgcaaggctg ggacctttgg cctacaatca     2880

gcaaggggct gtgttccctg caactgcaat tcttttgggt ctaagtcatt cgactgtgaa     2940

gagagtggac aatgttggtg ccaacctgga gtcacaggga agaaatgtga ccgctgtgcc     3000

cacggctatt tcaacttcca agaaggaggc tgcacagctt gtgaatgttc tcatctgggt     3060

aataattgtg acccaaagac tgggcgatgc atttgccctc ccaataccat tggagagaaa     3120

tgttctaaat gtgcacccaa tacctggggc cacagcatta ccactggttg taaggcttgt     3180

aactgcagca cagtgggatc cttggatttc caatgcaatg taaatacagg ccaatgcaac     3240

tgtcatccaa aattctctgg tgcaaaatgt acagagtgca gtcgaggtca ctggaactac     3300

cctcgctgca atctctgtga ctgcttcctc cctgggacag atgccacaac ctgtgattca     3360

gagactaaaa aatgctcctg tagtgatcaa actgggcagt gcacttgtaa ggtgaatgtg     3420

gaaggcatcc actgtgacag atgccggcct ggcaaattcg gactcgatgc caagaatcca     3480

cttggctgca gcagctgcta ttgcttcggc actactaccc agtgctctga agcaaaagga     3540

ctgatccgga cgtgggtgac tctgaaggct gagcagacca ttctacccct ggtagatgag     3600

gctctgcagc acacgaccac caagggcatt gtttttcaac atccagagat tgttgcccac     3660

atggacctga tgagagaaga tctccatttg gaaccttttt attggaaact tccagaacaa     3720

tttgaaggaa agaagttgat ggcctatggg ggcaaactca agtatgcaat ctatttcgag     3780

gctcgggaag aaacaggttt ctctacatat aatcctcaag tgatcattcg aggtgggaca     3840

cctactcatg ctagaattat cgtcaggcat atggctgctc ctctgattgg ccaattgaca     3900

aggcatgaaa ttgaaatgac agagaaagaa tggaaatatt atggggatga tcctcgagtc     3960

catagaactg tgacccgaga agacttcttg gatatactat atgatattca ttacattctt     4020

atcaaagcta cttatggaaa tttcatgcga caaagcagga tttctgaaat ctcaatggag     4080

gtagctgaac aaggacgtgg aacaacaatg actcctccag ctgacttgat tgaaaaatgt     4140

gattgtcccc tgggctattc tggcctgtcc tgtgaggcat gcttgccggg attttatcga     4200

ctgcgttctc aaccaggtgg ccgcacccct ggaccaaccc tgggcacctg tgttccatgt     4260

caatgtaatg gacacagcag cctgtgtgac cctgaaacat cgatatgcca gaattgtcaa     4320

catcacactg ctggtgactt ctgtgaacga tgtgctcttg gatactatgg aattgtcaag     4380

ggattgccaa atgactgtca gcaatgtgcc tgccctctga tttcttccag taacaatttc     4440

agcccctctt gtgtcgcaga aggacttgac gactaccgct gcacggcttg tccacgggga     4500

tatgaaggcc agtactgtga aaggtgtgcc cctggctata ctggcagtcc aggcaaccct     4560

ggaggctcct gccaagaatg tgagtgtgat ccctatggct cactgcctgt gccctgtgac     4620

cctgtcacag gattctgcac gtgccgacct ggagccacgg gaaggaagtg tgacggctgc     4680

aagcactggc atgcacgcga gggctgggag tgtgtttttt gtggagatga gtgcactggc     4740

cttcttctcg gtgacttggc tcgcctggag cagatggtca tgagcatcaa cctcactggt     4800

ccgctgcctg cgccatataa aatgctgtat ggtcttgaaa atatgactca ggagctaaag     4860

cacttgctgt cacctcagcg ggccccagag aggcttattc agctggcaga gggcaatctg     4920

aatacactcg tgaccgaaat gaacgagctg ctgaccaggg ctaccaaagt gacagcagat     4980

ggcgagcaga ccggacagga tgctgagagg accaacacaa gagcaaagtc cctgggagaa     5040

ttcattaagg agcttgcccg ggatgcagaa gctgtaaatg aaaaagctat aaaactaaat     5100

gaaactctag gaactcgaga cgaggccttt gagagaaatt tggaagggct tcagaaagag     5160

attgaccaga tgattaaaga actgaggagg aaaaatctag agacacaaaa ggaaattgct     5220

gaagatgagt tggtagctgc agaagccctt ctgaaaaaag tgaagaagct gtttggagag     5280

tcccgggggg aaaatgaaga aatggagaag gatctccggg aaaaactggc tgactacaaa     5340

aacaaagttg atgatgcttg ggaccttttg agagaagcca cagataaaat cagagaagct     5400

aatcgcctat ttgcagtaaa tcagaaaaac atgactgcat tggagaaaaa gaaggaggct     5460

gttgaaagcg gcaaacgaca aattgagaac actttaaaag agggcaatga catactcgat     5520

gaagccaacc gtcttgcaga tgaaatcaac tccatcatag actatgttga agacatccaa     5580

actaaattgc cacctatgtc tgaggagctt aatgataaaa tagatgacct ctcccaagaa     5640

ataaaggaca ggaagcttgc tgagaaggtg tcccaggctg agagccacgc agctcagttg     5700

aatgactcat ctgctgtcct tgatggaatc cttgatgagg ctaaaaacat ctccttcaat     5760

gccactgcag ccttcaaagc ttacagcaat attaaggact atattgatga agctgagaaa     5820

gttgccaaag aagccaaaga tcttgcacat gaagctacaa aactggcaac aggtcctcgg     5880

ggtttattaa aggaagatgc caaaggctgt cttcagaaaa gcttcaggat tcttaacgaa     5940

gccaagaagt tagcaaatga tgtaaaagaa aatgaagacc atctaaatgg cttaaaaacc     6000

aggatagaaa atgctgatgc tagaaatggg gatctcttga gaactttgaa tgacactttg     6060

ggaaagttat cagctattcc aaatgataca gctgctaaac tgcaagctgt taaggacaaa     6120

gccagacaag ccaacgacac agctaaagat gtactggcac agattacaga gctccaccag     6180

aacctcgatg gcctgaagaa gaattacaat aaactagcag acagcgtcgc caaaacgaat     6240

gctgtggtta aagatccttc caagaacaaa atcattgccg atgcagatgc cactgtcaaa     6300

aatttagaac aggaagctga ccggctaata gataaactca aacccatcaa ggaacttgag     6360

gataacctaa agaaaaacat ctctgagata aaggaattga taaaccaagc tcggaaacaa     6420

gccaattcta tcaaagtatc tgtgtcttca ggaggtgact gcattcgaac atacaaacca     6480

gaaatcaaga aaggaagtta caataatatt gttgtcaacg taaagacagc tgttgctgat     6540

aacctcctct tttatcttgg aagtgccaaa tttattgact ttctggctat agaaatgcgt     6600

aaaggcaaag tcagcttcct ctgggatgtt ggatctggag ttggacgtgt agagtaccca     6660

gatttgacta ttgatgactc atattggtac cgtatcgtag catcaagaac tgggagaaat     6720

ggaactattt ctgtgagagc cctggatgga cccaaagcca gcattgtgcc cagcacacac     6780

cattcgacgt ctcctccagg gtacacgatt ctagatgtgg atgcaaatgc aatgctgttt     6840

gttggtggcc tgactgggaa attaaagaag gctgatgctg tacgtgtgat tacattcact     6900

ggctgcatgg gagaaacata ctttgacaac aaacctatag gtttgtggaa tttccgagaa     6960

aaagaaggtg actgcaaagg atgcactgtc agtcctcagg tggaagatag tgaggggact     7020

attcaatttg atggagaagg ttatgcattg gtcagccgtc ccattcgctg gtaccccaac     7080

atctccactg tcatgttcaa gttcagaaca ttttcttcga gtgctcttct gatgtatctt     7140

gccacacgag acctgagaga tttcatgagt gtggagctca ctgatgggca cataaaagtc     7200

agttacgatc tgggctcagg aatggcttcc gttgtcagca atcaaaacca taatgatggg     7260

aaatggaaat cattcactct gtcaagaatt caaaaacaag ccaatatatc aattgtagat     7320

atagatacta atcaggagga gaatatagca acttcgtctt ctggaaacaa ctttggtctt     7380

gacttgaaag cagatgacaa aatatatttt ggtggcctgc caacgctgag aaacttgagt     7440

atgaaagcaa ggccagaagt aaatctgaag aaatattccg gctgcctcaa agatattgaa     7500

atttcaagaa ctccgtacaa tatactcagt agtcccgatt atgttggtgt taccaaagga     7560

tgttccctgg agaatgttta cacagttagc tttcctaagc ctggttttgt ggagctctcc     7620

cctgtgccaa ttgatgtagg aacagaaatc aacctgtcat tcagcaccaa gaatgagtcc     7680

ggcatcattc ttttgggaag tggagggaca ccagcaccac ctaggagaaa acgaaggcag     7740

actggacagg cctattatgc aatactcctc aacaggggcc gtctggaagt gcatctctcc     7800

acaggggcac gaacaatgag gaaaattgtg atcagaccag agccgaatct gtttcatgat     7860

ggaagagaac attccgttca tgtagagcga actagaggca tctttacagt tcaagtggat     7920

gaaaacagaa gatacatgca aaacctgaca gttgaacagc ctatcgaagt taaaaagctt     7980

ttcgttgggg gtgctccacc tgaatttcaa ccttccccac tcagaaatat tcctcctttt     8040

gaaggctgca tatggaatct tgttattaac tctgtcccca tggactttgc aaggcctgtg     8100

tccttcaaaa atgctgacat tggtcgctgt gcccatcaga aactccgtga agatgaagat     8160

ggagcagctc cagctgaaat agttatccag cctgagccag ttcccacccc agcctttcct     8220

acgcccaccc cagttctgac acatggtcct tgtgctgcag aatcagaacc agctcttttg     8280

atagggagca agcagttcgg gctttcaaga aacagtcaca ttgcaattgc atttgatgac     8340

accaaagtta aaaaccgtct cacaattgag ttggaagtaa gaaccgaagc tgaatccggc     8400

ttgctttttt acatggctcg catcaatcat gctgattttg caacagttca gctgagaaat     8460

ggattgccct acttcagcta tgacttgggg agtggggaca cccacaccat gatccccacc     8520

aaaatcaatg atggccagtg gcacaagatt aagataatga gaagtaagca agaaggaatt     8580

ctttatgtag atggggcttc caacagaacc atcagtccca aaaaagccga catcctggat     8640

gtcgtgggaa tgctgtatgt tggtgggtta cccatcaact acactacccg aagaattggt     8700

ccagtgacct atagcattga tggctgcgtc aggaatctcc acatggcaga ggcccctgcc     8760

gatctggaac aacccacctc cagcttccat gttgggacat gttttgcaaa tgctcagagg     8820

ggaacatatt ttgacggaac cggttttgcc aaagcagttg gtggattcaa agtgggattg     8880

gaccttcttg tagaatttga attccgcaca actacaacga ctggagttct tctggggatc     8940

agtagtcaaa aaatggatgg aatgggtatt gaaatgattg atgaaaagtt gatgtttcat     9000

gtggacaatg gtgcgggcag attcactgct gtctatgatg ctggggttcc agggcatttg     9060

tgtgatggac aatggcataa agtcactgcc aacaagatca aacaccgcat tgagctcaca     9120

gtcgatggga accaggtgga agcccaaagc ccaaacccag catctacatc agctgacaca     9180

aatgaccctg tgtttgttgg aggcttccca gatgacctca agcagtttgg cctaacaacc     9240

agtattccgt tccgaggttg catcagatcc ctgaagctca ccaaaggcac aggcaagcca     9300

ctggaggtta attttgccaa ggccctggaa ctgaggggcg ttcaacctgt atcatgccca     9360

gccaactaa                                                             9369


<210>  388
<211>  3122
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Ala Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210>  389
<211>  2475
<212>  DNA
<213>  Homo sapiens

<400>  389
atgacggtgc tgcaggaacc cgtccaggct gctatatggc aagcactaaa ccactatgct       60

taccgagatg cggttttcct cgcagaacgc ctttatgcag aagtacactc agaagaagcc      120

ttgtttttac tggcaacctg ttattaccgc tcaggaaagg catataaagc atatagactc      180

ttgaaaggac acagttgtac tacaccgcaa tgcaaatacc tgcttgcaaa atgttgtgtt      240

gatctcagca agcttgcaga aggggaacaa atcttatctg gtggagtgtt taataagcag      300

aaaagccatg atgatattgt tactgagttt ggtgattcag cttgctttac tctttcattg      360

ttgggacatg tatattgcaa gacagatcgg cttgccaaag gatcagaatg ttaccaaaag      420

agccttagtt taaatccttt cctctggtct ccctttgaat cattatgtga aataggtgaa      480

aagccagatc ctgaccaaac atttaaattc acatctttac agaactttag caactgtctg      540

cccaactctt gcacaacaca agtacctaat catagtttat ctcacagaca gcctgagaca      600

gttcttacgg aaacacccca ggacacaatt gaattaaaca gattgaattt agaatcttcc      660

aattcaaagt actccttgaa tacagattcc tcagtgtctt atattgattc agctgtaatt      720

tcacctgata ctgtcccact gggaacagga acttccatat tatctaaaca ggttcaaaat      780

aaaccaaaaa ctggtcgaag tttattagga ggaccagcag ctcttagtcc attaacccca      840

agttttggga ttttgccatt agaaacccca agtcctggag atggatccta tttacaaaac      900

tacactaata cacctcctgt aattgatgtg ccatccaccg gagccccttc aaaaaagtct      960

gttgccagaa tcggccaaac tggaacaaag tctgtcttct cacagagtgg aaatagccga     1020

gaggtaactc caattcttgc acaaacacaa agttctggtc cacaaacaag tacaacacct     1080

caggtattga gccccactat tacatctccc ccaaacgcac tgcctcgaag aagttcacga     1140

ctctttacta gtgacagctc cacaaccaag gagaatagca aaaaattaaa aatgaagttt     1200

ccacctaaaa tcccaaacag aaaaacaaaa agtaaaacta ataaaggagg aataactcaa     1260

cctaacataa atgatagcct ggaaattaca aaattggact cttccatcat ttcagaaggg     1320

aaaatatcca caatcacacc tcagattcag gcctttaatc tacaaaaagc agcagcagaa     1380

ggtttgatga gccttcttcg tgaaatgggg aaaggttatt tagctttgtg ttcatacaac     1440

tgcaaagaag ctataaatat tttgagccat ctaccttctc accactacaa tactggttgg     1500

gtactgtgcc aaattggaag ggcctatttt gaactttcag agtacatgca agctgaaaga     1560

atattctcag aggttagaag gattgagaat tatagagttg aaggcatgga gatctactct     1620

acaacacttt ggcatcttca aaaagatgtt gctctttcag ttctgtcaaa agacttaaca     1680

gacatggata aaaattcgcc agaggcctgg tgtgctgcag ggaactgttt cagtctgcaa     1740

cgggaacatg atattgcaat taaattcttc cagagagcta tccaagttga tccaaattac     1800

gcttatgcct atactctatt agggcatgag tttgtcttaa ctgaagaatt ggacaaagca     1860

ttagcttgtt ttcgaaatgc tatcagagtc aatcctagac attataatgc atggtatggt     1920

ttaggaatga tttattacaa gcaagaaaaa ttcagccttg cagaaatgca tttccaaaaa     1980

gcgcttgata tcaaccctca aagttcagtt ttactttgcc acattggagt agttcaacat     2040

gcactgaaaa aatcagagaa ggctttggat accctaaaca aagccattgt cattgatccc     2100

aagaaccctc tatgcaaatt tcacagagcc tcagttttat ttgcaaatga aaaatataag     2160

tctgctttac aagaacttga agaattgaaa caaattgttc ccaaagaatc cctcgtttac     2220

ttcttaatag gaaaggttta caagaagtta ggtcaaacgc acctcgccct gatgaatttc     2280

tcttgggcta tggatttaga tcctaaagga gccaataacc agattaaaga ggcaattgat     2340

aagcgttatc ttccagatga tgaggagcca ataacccaag aagaacagat catgggaaca     2400

gatgaatccc aggagagcag catgacagat gcggatgaca cacaacttca tgcagctgaa     2460

agtgatgaat tttaa                                                      2475


<210>  390
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Thr Val Leu Gln Glu Pro Val Gln Ala Ala Ile Trp Gln Ala Leu 
1               5                   10                  15      


Asn His Tyr Ala Tyr Arg Asp Ala Val Phe Leu Ala Glu Arg Leu Tyr 
            20                  25                  30          


Ala Glu Val His Ser Glu Glu Ala Leu Phe Leu Leu Ala Thr Cys Tyr 
        35                  40                  45              


Tyr Arg Ser Gly Lys Ala Tyr Lys Ala Tyr Arg Leu Leu Lys Gly His 
    50                  55                  60                  


Ser Cys Thr Thr Pro Gln Cys Lys Tyr Leu Leu Ala Lys Cys Cys Val 
65                  70                  75                  80  


Asp Leu Ser Lys Leu Ala Glu Gly Glu Gln Ile Leu Ser Gly Gly Val 
                85                  90                  95      


Phe Asn Lys Gln Lys Ser His Asp Asp Ile Val Thr Glu Phe Gly Asp 
            100                 105                 110         


Ser Ala Cys Phe Thr Leu Ser Leu Leu Gly His Val Tyr Cys Lys Thr 
        115                 120                 125             


Asp Arg Leu Ala Lys Gly Ser Glu Cys Tyr Gln Lys Ser Leu Ser Leu 
    130                 135                 140                 


Asn Pro Phe Leu Trp Ser Pro Phe Glu Ser Leu Cys Glu Ile Gly Glu 
145                 150                 155                 160 


Lys Pro Asp Pro Asp Gln Thr Phe Lys Phe Thr Ser Leu Gln Asn Phe 
                165                 170                 175     


Ser Asn Cys Leu Pro Asn Ser Cys Thr Thr Gln Val Pro Asn His Ser 
            180                 185                 190         


Leu Ser His Arg Gln Pro Glu Thr Val Leu Thr Glu Thr Pro Gln Asp 
        195                 200                 205             


Thr Ile Glu Leu Asn Arg Leu Asn Leu Glu Ser Ser Asn Ser Lys Tyr 
    210                 215                 220                 


Ser Leu Asn Thr Asp Ser Ser Val Ser Tyr Ile Asp Ser Ala Val Ile 
225                 230                 235                 240 


Ser Pro Asp Thr Val Pro Leu Gly Thr Gly Thr Ser Ile Leu Ser Lys 
                245                 250                 255     


Gln Val Gln Asn Lys Pro Lys Thr Gly Arg Ser Leu Leu Gly Gly Pro 
            260                 265                 270         


Ala Ala Leu Ser Pro Leu Thr Pro Ser Phe Gly Ile Leu Pro Leu Glu 
        275                 280                 285             


Thr Pro Ser Pro Gly Asp Gly Ser Tyr Leu Gln Asn Tyr Thr Asn Thr 
    290                 295                 300                 


Pro Pro Val Ile Asp Val Pro Ser Thr Gly Ala Pro Ser Lys Lys Ser 
305                 310                 315                 320 


Val Ala Arg Ile Gly Gln Thr Gly Thr Lys Ser Val Phe Ser Gln Ser 
                325                 330                 335     


Gly Asn Ser Arg Glu Val Thr Pro Ile Leu Ala Gln Thr Gln Ser Ser 
            340                 345                 350         


Gly Pro Gln Thr Ser Thr Thr Pro Gln Val Leu Ser Pro Thr Ile Thr 
        355                 360                 365             


Ser Pro Pro Asn Ala Leu Pro Arg Arg Ser Ser Arg Leu Phe Thr Ser 
    370                 375                 380                 


Asp Ser Ser Thr Thr Lys Glu Asn Ser Lys Lys Leu Lys Met Lys Phe 
385                 390                 395                 400 


Pro Pro Lys Ile Pro Asn Arg Lys Thr Lys Ser Lys Thr Asn Lys Gly 
                405                 410                 415     


Gly Ile Thr Gln Pro Asn Ile Asn Asp Ser Leu Glu Ile Thr Lys Leu 
            420                 425                 430         


Asp Ser Ser Ile Ile Ser Glu Gly Lys Ile Ser Thr Ile Thr Pro Gln 
        435                 440                 445             


Ile Gln Ala Phe Asn Leu Gln Lys Ala Ala Ala Glu Gly Leu Met Ser 
    450                 455                 460                 


Leu Leu Arg Glu Met Gly Lys Gly Tyr Leu Ala Leu Cys Ser Tyr Asn 
465                 470                 475                 480 


Cys Lys Glu Ala Ile Asn Ile Leu Ser His Leu Pro Ser His His Tyr 
                485                 490                 495     


Asn Thr Gly Trp Val Leu Cys Gln Ile Gly Arg Ala Tyr Phe Glu Leu 
            500                 505                 510         


Ser Glu Tyr Met Gln Ala Glu Arg Ile Phe Ser Glu Val Arg Arg Ile 
        515                 520                 525             


Glu Asn Tyr Arg Val Glu Gly Met Glu Ile Tyr Ser Thr Thr Leu Trp 
    530                 535                 540                 


His Leu Gln Lys Asp Val Ala Leu Ser Val Leu Ser Lys Asp Leu Thr 
545                 550                 555                 560 


Asp Met Asp Lys Asn Ser Pro Glu Ala Trp Cys Ala Ala Gly Asn Cys 
                565                 570                 575     


Phe Ser Leu Gln Arg Glu His Asp Ile Ala Ile Lys Phe Phe Gln Arg 
            580                 585                 590         


Ala Ile Gln Val Asp Pro Asn Tyr Ala Tyr Ala Tyr Thr Leu Leu Gly 
        595                 600                 605             


His Glu Phe Val Leu Thr Glu Glu Leu Asp Lys Ala Leu Ala Cys Phe 
    610                 615                 620                 


Arg Asn Ala Ile Arg Val Asn Pro Arg His Tyr Asn Ala Trp Tyr Gly 
625                 630                 635                 640 


Leu Gly Met Ile Tyr Tyr Lys Gln Glu Lys Phe Ser Leu Ala Glu Met 
                645                 650                 655     


His Phe Gln Lys Ala Leu Asp Ile Asn Pro Gln Ser Ser Val Leu Leu 
            660                 665                 670         


Cys His Ile Gly Val Val Gln His Ala Leu Lys Lys Ser Glu Lys Ala 
        675                 680                 685             


Leu Asp Thr Leu Asn Lys Ala Ile Val Ile Asp Pro Lys Asn Pro Leu 
    690                 695                 700                 


Cys Lys Phe His Arg Ala Ser Val Leu Phe Ala Asn Glu Lys Tyr Lys 
705                 710                 715                 720 


Ser Ala Leu Gln Glu Leu Glu Glu Leu Lys Gln Ile Val Pro Lys Glu 
                725                 730                 735     


Ser Leu Val Tyr Phe Leu Ile Gly Lys Val Tyr Lys Lys Leu Gly Gln 
            740                 745                 750         


Thr His Leu Ala Leu Met Asn Phe Ser Trp Ala Met Asp Leu Asp Pro 
        755                 760                 765             


Lys Gly Ala Asn Asn Gln Ile Lys Glu Ala Ile Asp Lys Arg Tyr Leu 
    770                 775                 780                 


Pro Asp Asp Glu Glu Pro Ile Thr Gln Glu Glu Gln Ile Met Gly Thr 
785                 790                 795                 800 


Asp Glu Ser Gln Glu Ser Ser Met Thr Asp Ala Asp Asp Thr Gln Leu 
                805                 810                 815     


His Ala Ala Glu Ser Asp Glu Phe 
            820                 


<210>  391
<211>  1947
<212>  DNA
<213>  Homo sapiens

<400>  391
atgtcgtggc tcttcggcgt taacaagggc cccaagggtg aaggcgcggg gccgccgccg       60

cctttgccgc ccgcgcagcc cggggccgag ggcggcgggg accgcggttt gggagaccgg      120

ccggcgccca aggacaaatg gagcaacttc gaccccaccg gcctggagcg cgccgccaag      180

gcggcgcgcg agctggagca ctcgcgttac gccaaggagg ccctgaatct ggcgcagatg      240

caggagcaga cgctgcagtt ggagcaacag tccaagctca aagagtatga ggccgccgtg      300

gagcagctca agagcgagca gatccgggcg caggctgagg agaggaggaa gaccctgagc      360

gaggagaccc ggcagcacca ggccagggcc cagtatcaag acaagctggc ccggcagcgc      420

tacgaggacc aactgaagca gcagcaactt ctcaatgagg agaatttacg gaagcaggag      480

gagtccgtgc agaagcagga agccatgcgg cgagccaccg tggagcggga gatggagctg      540

cggcacaaga atgagatgct gcgagtggag accgaggccc gggcgcgcgc caaggccgag      600

cgggagaatg cagacatcat ccgcgagcag atccgcctga aggcgtccga gcaccgtcag      660

accgtcttgg agtccatcag gacggctggc accttgtttg gggaaggatt ccgtgccttt      720

gtgacagacc gggacaaagt gacagccacg gtggctgggc tgacgctgct ggctgtcggg      780

gtctactcag ccaagaatgc gacagccgtc actggccgct tcatcgaggc tcggctgggg      840

aagccgtccc tagtgaggga gacgtcccgc atcacggtgc tggaggcgct gcggcacccc      900

atccaggtca gccggcggct cctcagtcga ccccaggacg tgctggaggg tgttgtgctt      960

agtcccagcc tggaagcacg ggtgcgcgac atcgccatag caaccaggaa caccaagaag     1020

aaccggggcc tgtacaggca catcctgctg tatgggccac caggcaccgg gaagacgctg     1080

tttgccaaga aactcgccct gcactcaggc atggactacg ccatcatgac aggcggggac     1140

gtggccccca tggggcggga aggcgtgacc gccatgcaca agctctttga ctgggccaat     1200

accagccggc gcggcctcct gctcttcatg gatgaagcag acgccttcct tcggaagcga     1260

gccactgagg agataagcaa ggacctcaga gccacactga acgccttcct gtaccacatg     1320

ggccaacaca gcaacaaatt catgctggtc ctggccagca atctgcctga gcagttcgac     1380

tgtgccatca acagccgcat tgacgtgatg gtccacttcg acctgccgca gcaggaggag     1440

cgggagcgcc tggtgagact gcattttgac aactgtgttc ttaagccggc cacagaagga     1500

aaacggcgcc tgaagctggc ccagtttgac tacgggagga agtgctcgga ggtcgctcgg     1560

ctgacggagg gcatgtcggg ccgggagatc gctcagctgg ccgtgtcctg gcaggccacg     1620

gcatatgcct ccaaggacgg ggtcctcact gaggccatga tggacgcctg tgtgcaagat     1680

gctgtccagc agtaccgaca gaagatgcgc tggctgaagg cggaggggcc tgggcgcggg     1740

gtcgagcacc ccctatccgg agtccaaggc gagaccctca cctcatggag cctggccacg     1800

gacccctcct acccctgcct tgccggcccc tgcacattta ggatatgctc ctggatgggg     1860

actgggctgt gcccagggcc tctgtccccc aggatgtctt gtggtggcgg tcggccgttc     1920

tgccccccag ggcaccccct gttgtag                                         1947


<210>  392
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ser Trp Leu Phe Gly Val Asn Lys Gly Pro Lys Gly Glu Gly Ala 
1               5                   10                  15      


Gly Pro Pro Pro Pro Leu Pro Pro Ala Gln Pro Gly Ala Glu Gly Gly 
            20                  25                  30          


Gly Asp Arg Gly Leu Gly Asp Arg Pro Ala Pro Lys Asp Lys Trp Ser 
        35                  40                  45              


Asn Phe Asp Pro Thr Gly Leu Glu Arg Ala Ala Lys Ala Ala Arg Glu 
    50                  55                  60                  


Leu Glu His Ser Arg Tyr Ala Lys Glu Ala Leu Asn Leu Ala Gln Met 
65                  70                  75                  80  


Gln Glu Gln Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Glu Tyr 
                85                  90                  95      


Glu Ala Ala Val Glu Gln Leu Lys Ser Glu Gln Ile Arg Ala Gln Ala 
            100                 105                 110         


Glu Glu Arg Arg Lys Thr Leu Ser Glu Glu Thr Arg Gln His Gln Ala 
        115                 120                 125             


Arg Ala Gln Tyr Gln Asp Lys Leu Ala Arg Gln Arg Tyr Glu Asp Gln 
    130                 135                 140                 


Leu Lys Gln Gln Gln Leu Leu Asn Glu Glu Asn Leu Arg Lys Gln Glu 
145                 150                 155                 160 


Glu Ser Val Gln Lys Gln Glu Ala Met Arg Arg Ala Thr Val Glu Arg 
                165                 170                 175     


Glu Met Glu Leu Arg His Lys Asn Glu Met Leu Arg Val Glu Thr Glu 
            180                 185                 190         


Ala Arg Ala Arg Ala Lys Ala Glu Arg Glu Asn Ala Asp Ile Ile Arg 
        195                 200                 205             


Glu Gln Ile Arg Leu Lys Ala Ser Glu His Arg Gln Thr Val Leu Glu 
    210                 215                 220                 


Ser Ile Arg Thr Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg Ala Phe 
225                 230                 235                 240 


Val Thr Asp Arg Asp Lys Val Thr Ala Thr Val Ala Gly Leu Thr Leu 
                245                 250                 255     


Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Ala Val Thr Gly 
            260                 265                 270         


Arg Phe Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg Glu Thr 
        275                 280                 285             


Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln Val Ser 
    290                 295                 300                 


Arg Arg Leu Leu Ser Arg Pro Gln Asp Val Leu Glu Gly Val Val Leu 
305                 310                 315                 320 


Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile Ala Thr Arg 
                325                 330                 335     


Asn Thr Lys Lys Asn Arg Gly Leu Tyr Arg His Ile Leu Leu Tyr Gly 
            340                 345                 350         


Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu Ala Leu His 
        355                 360                 365             


Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val Ala Pro Met 
    370                 375                 380                 


Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp Trp Ala Asn 
385                 390                 395                 400 


Thr Ser Arg Arg Gly Leu Leu Leu Phe Met Asp Glu Ala Asp Ala Phe 
                405                 410                 415     


Leu Arg Lys Arg Ala Thr Glu Glu Ile Ser Lys Asp Leu Arg Ala Thr 
            420                 425                 430         


Leu Asn Ala Phe Leu Tyr His Met Gly Gln His Ser Asn Lys Phe Met 
        435                 440                 445             


Leu Val Leu Ala Ser Asn Leu Pro Glu Gln Phe Asp Cys Ala Ile Asn 
    450                 455                 460                 


Ser Arg Ile Asp Val Met Val His Phe Asp Leu Pro Gln Gln Glu Glu 
465                 470                 475                 480 


Arg Glu Arg Leu Val Arg Leu His Phe Asp Asn Cys Val Leu Lys Pro 
                485                 490                 495     


Ala Thr Glu Gly Lys Arg Arg Leu Lys Leu Ala Gln Phe Asp Tyr Gly 
            500                 505                 510         


Arg Lys Cys Ser Glu Val Ala Arg Leu Thr Glu Gly Met Ser Gly Arg 
        515                 520                 525             


Glu Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala Tyr Ala Ser 
    530                 535                 540                 


Lys Asp Gly Val Leu Thr Glu Ala Met Met Asp Ala Cys Val Gln Asp 
545                 550                 555                 560 


Ala Val Gln Gln Tyr Arg Gln Lys Met Arg Trp Leu Lys Ala Glu Gly 
                565                 570                 575     


Pro Gly Arg Gly Val Glu His Pro Leu Ser Gly Val Gln Gly Glu Thr 
            580                 585                 590         


Leu Thr Ser Trp Ser Leu Ala Thr Asp Pro Ser Tyr Pro Cys Leu Ala 
        595                 600                 605             


Gly Pro Cys Thr Phe Arg Ile Cys Ser Trp Met Gly Thr Gly Leu Cys 
    610                 615                 620                 


Pro Gly Pro Leu Ser Pro Arg Met Ser Cys Gly Gly Gly Arg Pro Phe 
625                 630                 635                 640 


Cys Pro Pro Gly His Pro Leu Leu 
                645             


<210>  393
<211>  1527
<212>  DNA
<213>  Homo sapiens

<400>  393
atgagtccac caggcatgtg gcaaccaggc gtgcaacaac caggcatcag ccagcaagtc       60

ccaagccacc cagacatgag tcaaccaggc atgagccagc aagtccccag ccaaccaggc      120

ataaggcaac cagacactag ccaatcatgt aagaaccaaa cagacatgag ccaaccagac      180

gcaaaccaat caagtttatc agattccaac caaacaggta taatccagcc aagcccaagc      240

ttacttggta tgaaccaaat ggacatgaac caatggagtg caagcctata tgaaatgaac      300

caagtggaca tgaaacaacc aagcatgagc caagctggca tgaggcaatc aggtacaaac      360

ctaccagaca taaaccaacc tggcatgaaa caaccaggca catggcaatt aggtaggagc      420

caaccaggca tgtggccaca aagcctgagc gaactagtcc tgagtgaagc aagcataagc      480

caaccaggtc caccgcaacg agccccaagc caatcaggcc ccagacaatc aagcacgagc      540

caagcaggca caaaccaatc aggtataagc caaccagtga tgtggcaact agacatgaga      600

cagtcaggtg ggagccaacc aagcatgaga caagtaggca ccagccaatc aggcacaagc      660

caaataggca tgagccaacc aggcacatgg caaacaggcc tgagccaacc agtcccgagg      720

caaccaaaca agagtccacc aggcatgtgg caacgaggca tgtggcaacc aggcatgagc      780

cagcaagtcc ccagccaact aggcatgaga caaccaggca ctagccaatc aagtaagaac      840

caaacaggca tgagccatcc aggcaggggc caaccaggca tatgggaacc ggggccgagt      900

cagccaggcc tgagccaaca agacctgaac caattagtgc tgagccaacc aggcctgagt      960

caaccaggca ggagccaacc aagtgtgagc caaatgggca tgaggcaaac aagcatggat     1020

tactttcaaa taagacatgc agaggctgga gactgcccag aaattttgcg actgattaaa     1080

gaattggctg cctgtgaaaa catgctagat gcaatggagt taacagcagc tgatttactc     1140

agagatggct ttggggacaa tccccttttc tactgcctga ttgcagaagt aaacgatcaa     1200

caaaaaccat caggcaaact gactgttgga tttgccatgt actactttac atacgactca     1260

tggactggca aggtacttta cctagaggac ttttatgtca cacaagctta ccaaggccta     1320

ggtattggag ctgaaatgct gaagaggcta agtcagatag ccatcacaac tcaatgtaac     1380

tgcatgcact ttcttgtcgt catttggaac caggcttcta tcaactacta tactagtcga     1440

ggggctttag acctttcctc tgaggagggc tggcatctct tcaggtttaa cagagaagaa     1500

ctcctggaca tggcatggga agaatga                                         1527


<210>  394
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Ser Pro Pro Gly Met Trp Gln Pro Gly Val Gln Gln Pro Gly Ile 
1               5                   10                  15      


Ser Gln Gln Val Pro Ser His Pro Asp Met Ser Gln Pro Gly Met Ser 
            20                  25                  30          


Gln Gln Val Pro Ser Gln Pro Gly Ile Arg Gln Pro Asp Thr Ser Gln 
        35                  40                  45              


Ser Cys Lys Asn Gln Thr Asp Met Ser Gln Pro Asp Ala Asn Gln Ser 
    50                  55                  60                  


Ser Leu Ser Asp Ser Asn Gln Thr Gly Ile Ile Gln Pro Ser Pro Ser 
65                  70                  75                  80  


Leu Leu Gly Met Asn Gln Met Asp Met Asn Gln Trp Ser Ala Ser Leu 
                85                  90                  95      


Tyr Glu Met Asn Gln Val Asp Met Lys Gln Pro Ser Met Ser Gln Ala 
            100                 105                 110         


Gly Met Arg Gln Ser Gly Thr Asn Leu Pro Asp Ile Asn Gln Pro Gly 
        115                 120                 125             


Met Lys Gln Pro Gly Thr Trp Gln Leu Gly Arg Ser Gln Pro Gly Met 
    130                 135                 140                 


Trp Pro Gln Ser Leu Ser Glu Leu Val Leu Ser Glu Ala Ser Ile Ser 
145                 150                 155                 160 


Gln Pro Gly Pro Pro Gln Arg Ala Pro Ser Gln Ser Gly Pro Arg Gln 
                165                 170                 175     


Ser Ser Thr Ser Gln Ala Gly Thr Asn Gln Ser Gly Ile Ser Gln Pro 
            180                 185                 190         


Val Met Trp Gln Leu Asp Met Arg Gln Ser Gly Gly Ser Gln Pro Ser 
        195                 200                 205             


Met Arg Gln Val Gly Thr Ser Gln Ser Gly Thr Ser Gln Ile Gly Met 
    210                 215                 220                 


Ser Gln Pro Gly Thr Trp Gln Thr Gly Leu Ser Gln Pro Val Pro Arg 
225                 230                 235                 240 


Gln Pro Asn Lys Ser Pro Pro Gly Met Trp Gln Arg Gly Met Trp Gln 
                245                 250                 255     


Pro Gly Met Ser Gln Gln Val Pro Ser Gln Leu Gly Met Arg Gln Pro 
            260                 265                 270         


Gly Thr Ser Gln Ser Ser Lys Asn Gln Thr Gly Met Ser His Pro Gly 
        275                 280                 285             


Arg Gly Gln Pro Gly Ile Trp Glu Pro Gly Pro Ser Gln Pro Gly Leu 
    290                 295                 300                 


Ser Gln Gln Asp Leu Asn Gln Leu Val Leu Ser Gln Pro Gly Leu Ser 
305                 310                 315                 320 


Gln Pro Gly Arg Ser Gln Pro Ser Val Ser Gln Met Gly Met Arg Gln 
                325                 330                 335     


Thr Ser Met Asp Tyr Phe Gln Ile Arg His Ala Glu Ala Gly Asp Cys 
            340                 345                 350         


Pro Glu Ile Leu Arg Leu Ile Lys Glu Leu Ala Ala Cys Glu Asn Met 
        355                 360                 365             


Leu Asp Ala Met Glu Leu Thr Ala Ala Asp Leu Leu Arg Asp Gly Phe 
    370                 375                 380                 


Gly Asp Asn Pro Leu Phe Tyr Cys Leu Ile Ala Glu Val Asn Asp Gln 
385                 390                 395                 400 


Gln Lys Pro Ser Gly Lys Leu Thr Val Gly Phe Ala Met Tyr Tyr Phe 
                405                 410                 415     


Thr Tyr Asp Ser Trp Thr Gly Lys Val Leu Tyr Leu Glu Asp Phe Tyr 
            420                 425                 430         


Val Thr Gln Ala Tyr Gln Gly Leu Gly Ile Gly Ala Glu Met Leu Lys 
        435                 440                 445             


Arg Leu Ser Gln Ile Ala Ile Thr Thr Gln Cys Asn Cys Met His Phe 
    450                 455                 460                 


Leu Val Val Ile Trp Asn Gln Ala Ser Ile Asn Tyr Tyr Thr Ser Arg 
465                 470                 475                 480 


Gly Ala Leu Asp Leu Ser Ser Glu Glu Gly Trp His Leu Phe Arg Phe 
                485                 490                 495     


Asn Arg Glu Glu Leu Leu Asp Met Ala Trp Glu Glu 
            500                 505             


<210>  395
<211>  3162
<212>  DNA
<213>  Homo sapiens

<400>  395
atgtggcagc ccagacggcc ctggccccgc gtgccctggc gctgggcgct ggcgctgctg       60

gccctggttg gcgcggggct gtgccacgcc ggcccgcagc ccgggtatcc cgcgcggccc      120

agcgccagga acaagaactg gtgcgcctac atcgtgaaca agaatgtgag ctgctccgtg      180

ctggagggaa gtgagagttt tattcaggct cagtacaact gtgcctggaa ccagatgccc      240

tgtccgtcgg cgctggtgta tcgagtgaac ttcagaccta gatatgtcac taggtataag      300

acagtgacac agttggaatg gaggtgctgt cctggcttta gagggggaga ttgccaagaa      360

ggtcccaaag accccgtgaa gaccctccgc cccacgccgg ctcggcctcg aaacagcttg      420

aagaaagcca cagataatga acccagccaa ttctcagagc ccaggaagac tttgtcccca      480

actggtacag cacaaccaag ctggggggta gatccaaaag aggggcctca ggaacttcag      540

gaaaagaaga tacaggtgct agaggagaag gttcttcgac tcacaaggac ggttcttgac      600

ctccagtctt cccttgctgg agtgagtgaa aatctcaaac atgccactca ggatgatgcc      660

agtagaacac gggcaccagg gctcagcagc cagcacccca agcctgacac cactgttagt      720

ggagacacag aaacgggcca gagtcctggt gtcttcaaca ctaaggaatc tggcatgaag      780

gacatcaagt ctgaattggc tgaagtcaaa gatactctaa agaacaaaag tgacaagctg      840

gaagagctgg atggaaaagt gaagggctac gaagggcagc tcagacagct ccaggaagca      900

gctcagggcc cgacggtgac catgacaacc aacgaactct accaagccta tgtggacagt      960

aagatcgacg ccctgagaga ggagctcatg gagggcatgg acagaaagct ggctgacctg     1020

aaaaactcat gtgagtacaa gctcactggc ctccagcagc agtgtgatga ctatgggagc     1080

agctacctgg gagtgataga gctcataggg gagaaggaaa caagcctgag aaaagaaata     1140

aataacctcc gagcccggct acaggagcct tcagcccagg caaattgctg cgacagtgaa     1200

aagaatggtg acattggtca acagatcaag acattggacc agaaaatcga gagagttgct     1260

gaagccacca gaatgctgaa tggaagactg gacaatgagt ttgaccgcct tatagttcca     1320

gagccagatg tggattttga tgcaaaatgg aatgaactcg atgcaaggat caatgtgacg     1380

gagaagaacg ctgaagaaca ttgcttttac attgaggaaa cccttcgggg cgccattaat     1440

ggagaggtgg gtgacttgaa gcagcttgtt gatcagaaaa tacagtctct ggaagaccgt     1500

ctggggagcg ttctcctaca gatgaccaat aacactggtg cagagctcag tcccccaggg     1560

gcagcagccc tgccaggagt gtcagggtca ggagatgaac gggtcatgat ggaattaaac     1620

cacctgaagg acaaagttca agttgttgaa gacatttgcc tgctgaacat ccagggaaag     1680

cctcatggga tggaaggtgc cttgccaaac agggaagacc gcgcagtacg cgacagcctg     1740

caccttttga aatctctcaa cgacacgatg cacaggaagt ttcaagaaac cgaacaaacc     1800

atccagaaac ttcaacagga ttttagtttt ctttattctc aattaaacca cacagaaaat     1860

gatgtgactc atcttcaaaa ggaaatgagc aattgtagag caggtgaaaa cgctggcatg     1920

ggtaggttca ctaaggtggg tgagcaagaa aggacagtgg acaccctgcc gtccccccag     1980

caccccgtgg ctcattgctg cagtcagctg gaggagaggt ggcagaggtt gcagagccag     2040

gtcatctcgg agctggatgc ttgtaaggaa tgcacgcagg gggtccagag ggaggtctcc     2100

atggtggagg gcagggtgtc tcatatggag aaaacttgca gcaagctgga ctctatctca     2160

ggaaatcttc agaggatcaa ggaggggctc aacaagcatg tcagcagcct gtggaactgt     2220

gtcaggcaga tgaacggaac gctcaggtcg cattccagag acatttctgg cctgaagaat     2280

tcagtccagc agttctacag ccacgtcttc cagatttcta ctgatttgca agatctggtc     2340

aaatttcagc catcagcaaa ggcgccctcg cccccgccgc ccgcagaggc cccgaaggag     2400

ccgctgcagc ccgagcccgc cccgccgagg cccagcggcc ccgcaaccgc agaggaccct     2460

gggcgacggc ccgtcctgcc ccagcggccc cccgaggaga ggccgcccca gccgccaggc     2520

tccaccgggg tcatcgcgga gacgggccag gccgggcccc ccgcaggcgc aggcgtgtct     2580

gggcggggtc tgccgcgggg cgtggacggc cagaccggga gcggcaccgt ccccggcgca     2640

gaaggcttcg cgggcgcacc aggatacccg aagtcacctc ctgtagcttc cccaggagct     2700

ccggtgcctt ctctggtgtc tttttctgcg gggctcaccc agaagccttt ccccagtgat     2760

gggggcgttg tcctctttaa caaagtgctg gtgaacgacg gggatgttta caaccccagc     2820

accggggtct tcacggctcc ttatgatggg cgctacctga tcacggccac cctcaccccc     2880

gagagagacg cctacgtgga agcagtgctg tcggtctcca acgccagcgt ggcccagctg     2940

cataccgctg ggtacaggag agagttcctg gaataccacc gccctccagg agctttgcat     3000

acctgcgggg gcccgggggc attccacctc atcgtgcacc tgaaggcggg agatgcagtc     3060

aacgtcgtgg tgactggggg caagctggct cacacagact ttgatgaaat gtactccaca     3120

tttagtgggg ttttcttata tcctttcctt tcccacctct aa                        3162


<210>  396
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Trp Gln Pro Arg Arg Pro Trp Pro Arg Val Pro Trp Arg Trp Ala 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Val Gly Ala Gly Leu Cys His Ala Gly Pro 
            20                  25                  30          


Gln Pro Gly Tyr Pro Ala Arg Pro Ser Ala Arg Asn Lys Asn Trp Cys 
        35                  40                  45              


Ala Tyr Ile Val Asn Lys Asn Val Ser Cys Ser Val Leu Glu Gly Ser 
    50                  55                  60                  


Glu Ser Phe Ile Gln Ala Gln Tyr Asn Cys Ala Trp Asn Gln Met Pro 
65                  70                  75                  80  


Cys Pro Ser Ala Leu Val Tyr Arg Val Asn Phe Arg Pro Arg Tyr Val 
                85                  90                  95      


Thr Arg Tyr Lys Thr Val Thr Gln Leu Glu Trp Arg Cys Cys Pro Gly 
            100                 105                 110         


Phe Arg Gly Gly Asp Cys Gln Glu Gly Pro Lys Asp Pro Val Lys Thr 
        115                 120                 125             


Leu Arg Pro Thr Pro Ala Arg Pro Arg Asn Ser Leu Lys Lys Ala Thr 
    130                 135                 140                 


Asp Asn Glu Pro Ser Gln Phe Ser Glu Pro Arg Lys Thr Leu Ser Pro 
145                 150                 155                 160 


Thr Gly Thr Ala Gln Pro Ser Trp Gly Val Asp Pro Lys Glu Gly Pro 
                165                 170                 175     


Gln Glu Leu Gln Glu Lys Lys Ile Gln Val Leu Glu Glu Lys Val Leu 
            180                 185                 190         


Arg Leu Thr Arg Thr Val Leu Asp Leu Gln Ser Ser Leu Ala Gly Val 
        195                 200                 205             


Ser Glu Asn Leu Lys His Ala Thr Gln Asp Asp Ala Ser Arg Thr Arg 
    210                 215                 220                 


Ala Pro Gly Leu Ser Ser Gln His Pro Lys Pro Asp Thr Thr Val Ser 
225                 230                 235                 240 


Gly Asp Thr Glu Thr Gly Gln Ser Pro Gly Val Phe Asn Thr Lys Glu 
                245                 250                 255     


Ser Gly Met Lys Asp Ile Lys Ser Glu Leu Ala Glu Val Lys Asp Thr 
            260                 265                 270         


Leu Lys Asn Lys Ser Asp Lys Leu Glu Glu Leu Asp Gly Lys Val Lys 
        275                 280                 285             


Gly Tyr Glu Gly Gln Leu Arg Gln Leu Gln Glu Ala Ala Gln Gly Pro 
    290                 295                 300                 


Thr Val Thr Met Thr Thr Asn Glu Leu Tyr Gln Ala Tyr Val Asp Ser 
305                 310                 315                 320 


Lys Ile Asp Ala Leu Arg Glu Glu Leu Met Glu Gly Met Asp Arg Lys 
                325                 330                 335     


Leu Ala Asp Leu Lys Asn Ser Cys Glu Tyr Lys Leu Thr Gly Leu Gln 
            340                 345                 350         


Gln Gln Cys Asp Asp Tyr Gly Ser Ser Tyr Leu Gly Val Ile Glu Leu 
        355                 360                 365             


Ile Gly Glu Lys Glu Thr Ser Leu Arg Lys Glu Ile Asn Asn Leu Arg 
    370                 375                 380                 


Ala Arg Leu Gln Glu Pro Ser Ala Gln Ala Asn Cys Cys Asp Ser Glu 
385                 390                 395                 400 


Lys Asn Gly Asp Ile Gly Gln Gln Ile Lys Thr Leu Asp Gln Lys Ile 
                405                 410                 415     


Glu Arg Val Ala Glu Ala Thr Arg Met Leu Asn Gly Arg Leu Asp Asn 
            420                 425                 430         


Glu Phe Asp Arg Leu Ile Val Pro Glu Pro Asp Val Asp Phe Asp Ala 
        435                 440                 445             


Lys Trp Asn Glu Leu Asp Ala Arg Ile Asn Val Thr Glu Lys Asn Ala 
    450                 455                 460                 


Glu Glu His Cys Phe Tyr Ile Glu Glu Thr Leu Arg Gly Ala Ile Asn 
465                 470                 475                 480 


Gly Glu Val Gly Asp Leu Lys Gln Leu Val Asp Gln Lys Ile Gln Ser 
                485                 490                 495     


Leu Glu Asp Arg Leu Gly Ser Val Leu Leu Gln Met Thr Asn Asn Thr 
            500                 505                 510         


Gly Ala Glu Leu Ser Pro Pro Gly Ala Ala Ala Leu Pro Gly Val Ser 
        515                 520                 525             


Gly Ser Gly Asp Glu Arg Val Met Met Glu Leu Asn His Leu Lys Asp 
    530                 535                 540                 


Lys Val Gln Val Val Glu Asp Ile Cys Leu Leu Asn Ile Gln Gly Lys 
545                 550                 555                 560 


Pro His Gly Met Glu Gly Ala Leu Pro Asn Arg Glu Asp Arg Ala Val 
                565                 570                 575     


Arg Asp Ser Leu His Leu Leu Lys Ser Leu Asn Asp Thr Met His Arg 
            580                 585                 590         


Lys Phe Gln Glu Thr Glu Gln Thr Ile Gln Lys Leu Gln Gln Asp Phe 
        595                 600                 605             


Ser Phe Leu Tyr Ser Gln Leu Asn His Thr Glu Asn Asp Val Thr His 
    610                 615                 620                 


Leu Gln Lys Glu Met Ser Asn Cys Arg Ala Gly Glu Asn Ala Gly Met 
625                 630                 635                 640 


Gly Arg Phe Thr Lys Val Gly Glu Gln Glu Arg Thr Val Asp Thr Leu 
                645                 650                 655     


Pro Ser Pro Gln His Pro Val Ala His Cys Cys Ser Gln Leu Glu Glu 
            660                 665                 670         


Arg Trp Gln Arg Leu Gln Ser Gln Val Ile Ser Glu Leu Asp Ala Cys 
        675                 680                 685             


Lys Glu Cys Thr Gln Gly Val Gln Arg Glu Val Ser Met Val Glu Gly 
    690                 695                 700                 


Arg Val Ser His Met Glu Lys Thr Cys Ser Lys Leu Asp Ser Ile Ser 
705                 710                 715                 720 


Gly Asn Leu Gln Arg Ile Lys Glu Gly Leu Asn Lys His Val Ser Ser 
                725                 730                 735     


Leu Trp Asn Cys Val Arg Gln Met Asn Gly Thr Leu Arg Ser His Ser 
            740                 745                 750         


Arg Asp Ile Ser Gly Leu Lys Asn Ser Val Gln Gln Phe Tyr Ser His 
        755                 760                 765             


Val Phe Gln Ile Ser Thr Asp Leu Gln Asp Leu Val Lys Phe Gln Pro 
    770                 775                 780                 


Ser Ala Lys Ala Pro Ser Pro Pro Pro Pro Ala Glu Ala Pro Lys Glu 
785                 790                 795                 800 


Pro Leu Gln Pro Glu Pro Ala Pro Pro Arg Pro Ser Gly Pro Ala Thr 
                805                 810                 815     


Ala Glu Asp Pro Gly Arg Arg Pro Val Leu Pro Gln Arg Pro Pro Glu 
            820                 825                 830         


Glu Arg Pro Pro Gln Pro Pro Gly Ser Thr Gly Val Ile Ala Glu Thr 
        835                 840                 845             


Gly Gln Ala Gly Pro Pro Ala Gly Ala Gly Val Ser Gly Arg Gly Leu 
    850                 855                 860                 


Pro Arg Gly Val Asp Gly Gln Thr Gly Ser Gly Thr Val Pro Gly Ala 
865                 870                 875                 880 


Glu Gly Phe Ala Gly Ala Pro Gly Tyr Pro Lys Ser Pro Pro Val Ala 
                885                 890                 895     


Ser Pro Gly Ala Pro Val Pro Ser Leu Val Ser Phe Ser Ala Gly Leu 
            900                 905                 910         


Thr Gln Lys Pro Phe Pro Ser Asp Gly Gly Val Val Leu Phe Asn Lys 
        915                 920                 925             


Val Leu Val Asn Asp Gly Asp Val Tyr Asn Pro Ser Thr Gly Val Phe 
    930                 935                 940                 


Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile Thr Ala Thr Leu Thr Pro 
945                 950                 955                 960 


Glu Arg Asp Ala Tyr Val Glu Ala Val Leu Ser Val Ser Asn Ala Ser 
                965                 970                 975     


Val Ala Gln Leu His Thr Ala Gly Tyr Arg Arg Glu Phe Leu Glu Tyr 
            980                 985                 990         


His Arg Pro Pro Gly Ala Leu His  Thr Cys Gly Gly Pro  Gly Ala Phe 
        995                 1000                 1005             


His Leu  Ile Val His Leu Lys  Ala Gly Asp Ala Val  Asn Val Val 
    1010                 1015                 1020             


Val Thr  Gly Gly Lys Leu Ala  His Thr Asp Phe Asp  Glu Met Tyr 
    1025                 1030                 1035             


Ser Thr  Phe Ser Gly Val Phe  Leu Tyr Pro Phe Leu  Ser His Leu 
    1040                 1045                 1050             


<210>  397
<211>  1524
<212>  DNA
<213>  Homo sapiens

<400>  397
atggcccgac tgctcaggtc tgcaacctgg gagctgttcc cctggagggg ctactgctcc       60

cagaaggcaa agggagagct ctgcagggac ttcgtagagg ctctgaaggc cgtggtgggc      120

ggctcccacg tgtccactgc cgcggtggtc cgagagcagc acgggcgcga tgagtcggtg      180

cacaggtgcg aacctcctga tgctgtggtg tggccccaga acgtggagca ggtcagccgg      240

ctggcagccc tgtgctatcg ccaaggtgtg cccatcatcc cattcggcac cggcaccggg      300

cttgagggtg gcgtctgtgc tgtgcagggc ggcgtctgcg ttaacctgac gcatatggac      360

cgaatcctgg agctgaacca ggaggacttc tctgtggtgg tggagccagg tgtcacccgc      420

aaagccctca acgcccacct gcgggacagc ggcctctggt ttcccgtgga cccaggcgcg      480

gacgcctctc tctgtggcat ggcggccacc ggggcgtcgg ggaccaacgc ggtccgctac      540

ggcaccatgc gggacaacgt gctcaacctg gaggtggtgc tgcccgacgg gcggctgctg      600

cacacggcgg gccgaggccg gcatttccgc ttcggcttct ggccagaaat ccctcatcac      660

acagcctggt actcaccttg tgtgtccctg ggacgtagga agagtgcagc cggctacaac      720

ctcacggggc tcttcgtggg ctccgagggg acgctgggcc tcatcacagc caccaccctg      780

cgcctgcacc ctgcccctga ggccacagtg gccgccacgt gtgcgttccc cagtgtccag      840

gctgctgtgg acagcactgt acacatcctc caggctgcag tgcccgtagc ccgcattgag      900

ttcctggatg aagtcatgat ggatgcctgc aacaggtaca gcaagctgaa ttgcttagtg      960

gcgcccacac tcttcctgga gttccatggc tcccagcagg cactggagga gcagctgcag     1020

cgcacagagg agatagtcca gcagaacgga gcctctgact tctcctgggc caaggaggcc     1080

gaggagcgca gccggctttg gacagcacgg cacaatgcct ggtacgcagc cctggccacg     1140

cggccaggct gcaagggcta ctccacggat gtgtgtgtgc ccatctcccg gctgccggag     1200

atcgtggtgc agaccaagga ggatctgaat gcctcaggac tcacaggaag cattgtcggg     1260

catgtgggtg acggcaactt ccactgcatc ctgctggtca accctgatga cgccgaggaa     1320

ctgggcaggg tcaaggcttt tgcagaacag ctgggcaggc gggcactggc tctccacgga     1380

acgtgcacgg gggagcatgg catcggaatg ggcaagcggc agctgctgca ggaggaggtg     1440

ggcgccgtgg gcgtggagac catgcggcag ctcaaggccg tgctagaccc ccaaggcctc     1500

atgaatccag gcaaagtgct gtga                                            1524


<210>  398
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg 
1               5                   10                  15      


Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val 
            20                  25                  30          


Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala 
        35                  40                  45              


Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu 
    50                  55                  60                  


Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg 
65                  70                  75                  80  


Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly 
                85                  90                  95      


Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val 
            100                 105                 110         


Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu 
        115                 120                 125             


Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn 
    130                 135                 140                 


Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala 
145                 150                 155                 160 


Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn 
                165                 170                 175     


Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val 
            180                 185                 190         


Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His 
        195                 200                 205             


Phe Arg Phe Gly Phe Trp Pro Glu Ile Pro His His Thr Ala Trp Tyr 
    210                 215                 220                 


Ser Pro Cys Val Ser Leu Gly Arg Arg Lys Ser Ala Ala Gly Tyr Asn 
225                 230                 235                 240 


Leu Thr Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Leu Ile Thr 
                245                 250                 255     


Ala Thr Thr Leu Arg Leu His Pro Ala Pro Glu Ala Thr Val Ala Ala 
            260                 265                 270         


Thr Cys Ala Phe Pro Ser Val Gln Ala Ala Val Asp Ser Thr Val His 
        275                 280                 285             


Ile Leu Gln Ala Ala Val Pro Val Ala Arg Ile Glu Phe Leu Asp Glu 
    290                 295                 300                 


Val Met Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu Asn Cys Leu Val 
305                 310                 315                 320 


Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln Gln Ala Leu Glu 
                325                 330                 335     


Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln Asn Gly Ala Ser 
            340                 345                 350         


Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser Arg Leu Trp Thr 
        355                 360                 365             


Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr Arg Pro Gly Cys 
    370                 375                 380                 


Lys Gly Tyr Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu Pro Glu 
385                 390                 395                 400 


Ile Val Val Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu Thr Gly 
                405                 410                 415     


Ser Ile Val Gly His Val Gly Asp Gly Asn Phe His Cys Ile Leu Leu 
            420                 425                 430         


Val Asn Pro Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala Phe Ala 
        435                 440                 445             


Glu Gln Leu Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys Thr Gly 
    450                 455                 460                 


Glu His Gly Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu Glu Val 
465                 470                 475                 480 


Gly Ala Val Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val Leu Asp 
                485                 490                 495     


Pro Gln Gly Leu Met Asn Pro Gly Lys Val Leu 
            500                 505         


<210>  399
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  399
atggaaaaaa ggacatgtgc actctgcccc aaagatgtcg aatataatgt cctatacttt       60

gcacaatcag agaatatagc tgctcatgag aattgtttgc tgtattcttc aggacttgtg      120

gaatgtgagg atcaggatcc acttaatcct gatagaagtt ttgatgtgga atcagtaaag      180

aaagaaatcc agagaggaag gaagttgaaa tgcaaatttt gtcataaaag aggagccacc      240

gtgggatgtg atttaaaaaa ctgtaacaag aattaccact ttttctgtgc caagaaggac      300

gacgcagttc cacagtctga tggagttcga ggaatttata aactgctttg ccagcaacat      360

gctcaattcc cgatcatcgc tcaaagtgct aaattttcag gagtgaaaag aaaaagagga      420

aggaagaaac ccctctcagg caatcatgta cagccacccg aaacaatgaa atgtaataca      480

ttcataagac aagtgaaaga agagcatggc agacacacag atgcaactgt gaaagttcct      540

tttcttaaga aatgcaagga agcaggactt cttaattact tacttgaaga aatattagac      600

aaagttcatt caattccaga aaaactcatg gatgagacta cttcagaatc agactatgaa      660

gaaatcggga gtgcactttt tgactgtaga ttgttcgaag acacatttgt aaattttcaa      720

gcagcaatag agaaaaaaat tcatgcatct caacaaaggt ggcagcagtt gaaggaagag      780

attgagctac ttcaggactt aaaacaaacc ttgtgctctt ttcaagaaaa tagagatctt      840

atgtcaagtt ctacatcaat atcatccctg tcttattag                             879


<210>  400
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Glu Lys Arg Thr Cys Ala Leu Cys Pro Lys Asp Val Glu Tyr Asn 
1               5                   10                  15      


Val Leu Tyr Phe Ala Gln Ser Glu Asn Ile Ala Ala His Glu Asn Cys 
            20                  25                  30          


Leu Leu Tyr Ser Ser Gly Leu Val Glu Cys Glu Asp Gln Asp Pro Leu 
        35                  40                  45              


Asn Pro Asp Arg Ser Phe Asp Val Glu Ser Val Lys Lys Glu Ile Gln 
    50                  55                  60                  


Arg Gly Arg Lys Leu Lys Cys Lys Phe Cys His Lys Arg Gly Ala Thr 
65                  70                  75                  80  


Val Gly Cys Asp Leu Lys Asn Cys Asn Lys Asn Tyr His Phe Phe Cys 
                85                  90                  95      


Ala Lys Lys Asp Asp Ala Val Pro Gln Ser Asp Gly Val Arg Gly Ile 
            100                 105                 110         


Tyr Lys Leu Leu Cys Gln Gln His Ala Gln Phe Pro Ile Ile Ala Gln 
        115                 120                 125             


Ser Ala Lys Phe Ser Gly Val Lys Arg Lys Arg Gly Arg Lys Lys Pro 
    130                 135                 140                 


Leu Ser Gly Asn His Val Gln Pro Pro Glu Thr Met Lys Cys Asn Thr 
145                 150                 155                 160 


Phe Ile Arg Gln Val Lys Glu Glu His Gly Arg His Thr Asp Ala Thr 
                165                 170                 175     


Val Lys Val Pro Phe Leu Lys Lys Cys Lys Glu Ala Gly Leu Leu Asn 
            180                 185                 190         


Tyr Leu Leu Glu Glu Ile Leu Asp Lys Val His Ser Ile Pro Glu Lys 
        195                 200                 205             


Leu Met Asp Glu Thr Thr Ser Glu Ser Asp Tyr Glu Glu Ile Gly Ser 
    210                 215                 220                 


Ala Leu Phe Asp Cys Arg Leu Phe Glu Asp Thr Phe Val Asn Phe Gln 
225                 230                 235                 240 


Ala Ala Ile Glu Lys Lys Ile His Ala Ser Gln Gln Arg Trp Gln Gln 
                245                 250                 255     


Leu Lys Glu Glu Ile Glu Leu Leu Gln Asp Leu Lys Gln Thr Leu Cys 
            260                 265                 270         


Ser Phe Gln Glu Asn Arg Asp Leu Met Ser Ser Ser Thr Ser Ile Ser 
        275                 280                 285             


Ser Leu Ser Tyr 
    290         


<210>  401
<211>  1485
<212>  DNA
<213>  Homo sapiens

<400>  401
atgagtgcca cccggagtgc atacatggag gaagaaggcg tcttccactt ccacatggag       60

caccccgtgc ccgcctacct cgtggccctg gtggccggag acctcaagcc ggcagacatc      120

gggcccagga gccgcgtgtg ggccgagcca tgcctcctgc ccacggccac cagcaagctg      180

tcgggcgcag tggagcagtg gctgagtgca gctgagcggc tgtatgggcc ctacatgtgg      240

ggcaggtacg acattgtctt cctgccaccc tccttcccca tcgtggccat ggagaacccc      300

tgcctcacct tcatcatctc ctccatcctg gagagcgatg agttcctggt catcgatgtc      360

atccacgagg tggcccacag ttggttcggc aacgctgtca ccaacgccac gtgggaagag      420

atgtggctga gcgagggcct ggccacctat gcccagcgcc gtatcaccac cgagacctac      480

ggtgctgcct tcacctgcct ggagactgcc ttccgcctgg acgccctgca ccggcagatg      540

aagcttctgg gagaggacag cccggtcagc aaactgcagg tcaagctgga gccaggagtg      600

aatcccagcc acctgatgaa cctgttcacc tacgagaagg gctactgctt cgtgtactac      660

ctgtcccagc tctgcggaga cccacagcgc tttgatgact ttctccgagc ctatgtggag      720

aagtacaagt tcaccagcgt ggtggcccag gacctgctgg actccttcct gagcttcttc      780

ccggagctga aggagcagag cgtggactgc cgggcagggc tggaattcga gcgctggctc      840

aatgccacag gcccgccgct ggctgagccg gacctgtctc agggatccag cctgacccgg      900

cccgtggagg cccttttcca gctgtggacc gcagaacctc tggaccaggc agctgcctcg      960

gccagcgcca ttgacatctc caagtggagg accttccaga cagcactctt cctggaccgg     1020

ctcctggatg ggtccccgct gccgcaggag gtggtgatga gcctgtccaa gtgctactcc     1080

tccctgctgg actcgatgaa cgctgagatc cgcatccgct ggctgcagat tgtggtccgc     1140

aacgactact atcctgacct ccacagggtg cggcgcttcc tggagagcca gatgtcacgc     1200

atgtacacca tcccgctgta cgaggacctc tgcaccggtg ccctcaagtc cttcgcgctg     1260

gaggtcttct accagacgca gggccggctg caccccaacc tgcgcagagc catccagcag     1320

atcctgtccc agggcctggg ctccagcaca gagcccgcct cagagcccag cacggagctg     1380

ggcaaggctg aagcagacac agactcggac gcacaggccc tgctgcttgg ggacgaggcc     1440

cccagcagtg ccatctctct cagggacgtc aatgtgtctg cctag                     1485


<210>  402
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Ser Ala Thr Arg Ser Ala Tyr Met Glu Glu Glu Gly Val Phe His 
1               5                   10                  15      


Phe His Met Glu His Pro Val Pro Ala Tyr Leu Val Ala Leu Val Ala 
            20                  25                  30          


Gly Asp Leu Lys Pro Ala Asp Ile Gly Pro Arg Ser Arg Val Trp Ala 
        35                  40                  45              


Glu Pro Cys Leu Leu Pro Thr Ala Thr Ser Lys Leu Ser Gly Ala Val 
    50                  55                  60                  


Glu Gln Trp Leu Ser Ala Ala Glu Arg Leu Tyr Gly Pro Tyr Met Trp 
65                  70                  75                  80  


Gly Arg Tyr Asp Ile Val Phe Leu Pro Pro Ser Phe Pro Ile Val Ala 
                85                  90                  95      


Met Glu Asn Pro Cys Leu Thr Phe Ile Ile Ser Ser Ile Leu Glu Ser 
            100                 105                 110         


Asp Glu Phe Leu Val Ile Asp Val Ile His Glu Val Ala His Ser Trp 
        115                 120                 125             


Phe Gly Asn Ala Val Thr Asn Ala Thr Trp Glu Glu Met Trp Leu Ser 
    130                 135                 140                 


Glu Gly Leu Ala Thr Tyr Ala Gln Arg Arg Ile Thr Thr Glu Thr Tyr 
145                 150                 155                 160 


Gly Ala Ala Phe Thr Cys Leu Glu Thr Ala Phe Arg Leu Asp Ala Leu 
                165                 170                 175     


His Arg Gln Met Lys Leu Leu Gly Glu Asp Ser Pro Val Ser Lys Leu 
            180                 185                 190         


Gln Val Lys Leu Glu Pro Gly Val Asn Pro Ser His Leu Met Asn Leu 
        195                 200                 205             


Phe Thr Tyr Glu Lys Gly Tyr Cys Phe Val Tyr Tyr Leu Ser Gln Leu 
    210                 215                 220                 


Cys Gly Asp Pro Gln Arg Phe Asp Asp Phe Leu Arg Ala Tyr Val Glu 
225                 230                 235                 240 


Lys Tyr Lys Phe Thr Ser Val Val Ala Gln Asp Leu Leu Asp Ser Phe 
                245                 250                 255     


Leu Ser Phe Phe Pro Glu Leu Lys Glu Gln Ser Val Asp Cys Arg Ala 
            260                 265                 270         


Gly Leu Glu Phe Glu Arg Trp Leu Asn Ala Thr Gly Pro Pro Leu Ala 
        275                 280                 285             


Glu Pro Asp Leu Ser Gln Gly Ser Ser Leu Thr Arg Pro Val Glu Ala 
    290                 295                 300                 


Leu Phe Gln Leu Trp Thr Ala Glu Pro Leu Asp Gln Ala Ala Ala Ser 
305                 310                 315                 320 


Ala Ser Ala Ile Asp Ile Ser Lys Trp Arg Thr Phe Gln Thr Ala Leu 
                325                 330                 335     


Phe Leu Asp Arg Leu Leu Asp Gly Ser Pro Leu Pro Gln Glu Val Val 
            340                 345                 350         


Met Ser Leu Ser Lys Cys Tyr Ser Ser Leu Leu Asp Ser Met Asn Ala 
        355                 360                 365             


Glu Ile Arg Ile Arg Trp Leu Gln Ile Val Val Arg Asn Asp Tyr Tyr 
    370                 375                 380                 


Pro Asp Leu His Arg Val Arg Arg Phe Leu Glu Ser Gln Met Ser Arg 
385                 390                 395                 400 


Met Tyr Thr Ile Pro Leu Tyr Glu Asp Leu Cys Thr Gly Ala Leu Lys 
                405                 410                 415     


Ser Phe Ala Leu Glu Val Phe Tyr Gln Thr Gln Gly Arg Leu His Pro 
            420                 425                 430         


Asn Leu Arg Arg Ala Ile Gln Gln Ile Leu Ser Gln Gly Leu Gly Ser 
        435                 440                 445             


Ser Thr Glu Pro Ala Ser Glu Pro Ser Thr Glu Leu Gly Lys Ala Glu 
    450                 455                 460                 


Ala Asp Thr Asp Ser Asp Ala Gln Ala Leu Leu Leu Gly Asp Glu Ala 
465                 470                 475                 480 


Pro Ser Ser Ala Ile Ser Leu Arg Asp Val Asn Val Ser Ala 
                485                 490                 


<210>  403
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  403
atgcggctgc acagacttcg tgcgcggctg agcgcggtgg cctgtgggct tctgctgctt       60

cttgtccggg gccagggcca ggactcagcc agtcccatcc ggaccacaca cacggggcag      120

gtgctgggga gtcttgtcca tgtgaagggc gccaatgccg gggtccaaac cttcctggga      180

attccatttg ccaagccacc tctaggtccg ctgcgatttg caccccctga gccccctgaa      240

tcttggagtg gtgtgaggga tggaaccacc catccggcca tgtgtctaca ggacctcacc      300

gcagtggagt cagagtttct tagccagttc aacatgacct tcccttccga ctccatgtct      360

gaggactgcc tgtacctcag catctacacg ccggcccata gccatgaagg ctctaacctg      420

ccggtgatgg tgtggatcca cggtggtgcg cttgtttttg gcatggcttc cttgtatgat      480

ggttccatgc tggctgcctt ggagaacgtg gtggtggtca tcatccagta ccgcctgggt      540

gtcctgggct tcttcagcac tggagacaag cacgcaaccg gcaactgggg ctacctggac      600

caagtggctg cactacgctg ggtccagcag aatatcgccc actttggagg caaccctgac      660

cgtgtcacca tttttggcga gtctgcgggt ggcacgagtg tgtcttcgct tgttgtgtcc      720

cccatatccc aaggactctt ccacggagcc atcatggaga gtggcgtggc cctcctgccc      780

ggcctcattg ccagctcagc tgatgtcatc tccacggtgg tggccaacct gtctgcctgt      840

gaccaagttg actctgaggc cctggtgggc tgcctgcggg gcaagagtaa agaggagatt      900

cttgcaatta acaagccttt caagatgatc cccggagtgg tggatggggt cttcctgccc      960

aggcaccccc aggagctgct ggcctctgcc gactttcagc ctgtccctag cattgttggt     1020

gtcaacaaca atgaattcgg ctggctcatc cccaaggtca tgaggatcta tgatacccag     1080

aaggaaatgg acagagaggc ctcccaggct gctctgcaga aaatgttaac gctgctgatg     1140

ttgcctccta catttggtga cctgctgagg gaggagtaca ttggggacaa tggggatccc     1200

cagaccctcc aagcgcagtt ccaggagatg atggcggact ccatgtttgt gatccctgca     1260

ctccaagtag cacattttca gtgttcccgg gcccctgtgt acttctacga gttccagcat     1320

cagcccagct ggctcaagaa catcaggcca ccgcacatga aggcagacca tggtgatgag     1380

cttccttttg ttttcagaag tttctttggg ggcaactaca ttaaattcac tgaggaagag     1440

gagcagctaa gcaggaagat gatgaagtac tgggccaact ttgcgagaaa tgggaacccg     1500

aatggcgagg gtctgccaca ctggccgctg ttcgaccagg aggagcaata cctgcagctg     1560

aacctacagc ctgcggtggg ccgggctctg aaggcccaca ggctccagtt ctggaagaag     1620

gcgctgcccc aaaagatcca ggagctcgag gagcctgaag agagacacac agagctgtag     1680


<210>  404
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Arg Leu His Arg Leu Arg Ala Arg Leu Ser Ala Val Ala Cys Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Arg Gly Gln Gly Gln Asp Ser Ala Ser Pro 
            20                  25                  30          


Ile Arg Thr Thr His Thr Gly Gln Val Leu Gly Ser Leu Val His Val 
        35                  40                  45              


Lys Gly Ala Asn Ala Gly Val Gln Thr Phe Leu Gly Ile Pro Phe Ala 
    50                  55                  60                  


Lys Pro Pro Leu Gly Pro Leu Arg Phe Ala Pro Pro Glu Pro Pro Glu 
65                  70                  75                  80  


Ser Trp Ser Gly Val Arg Asp Gly Thr Thr His Pro Ala Met Cys Leu 
                85                  90                  95      


Gln Asp Leu Thr Ala Val Glu Ser Glu Phe Leu Ser Gln Phe Asn Met 
            100                 105                 110         


Thr Phe Pro Ser Asp Ser Met Ser Glu Asp Cys Leu Tyr Leu Ser Ile 
        115                 120                 125             


Tyr Thr Pro Ala His Ser His Glu Gly Ser Asn Leu Pro Val Met Val 
    130                 135                 140                 


Trp Ile His Gly Gly Ala Leu Val Phe Gly Met Ala Ser Leu Tyr Asp 
145                 150                 155                 160 


Gly Ser Met Leu Ala Ala Leu Glu Asn Val Val Val Val Ile Ile Gln 
                165                 170                 175     


Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Lys His Ala 
            180                 185                 190         


Thr Gly Asn Trp Gly Tyr Leu Asp Gln Val Ala Ala Leu Arg Trp Val 
        195                 200                 205             


Gln Gln Asn Ile Ala His Phe Gly Gly Asn Pro Asp Arg Val Thr Ile 
    210                 215                 220                 


Phe Gly Glu Ser Ala Gly Gly Thr Ser Val Ser Ser Leu Val Val Ser 
225                 230                 235                 240 


Pro Ile Ser Gln Gly Leu Phe His Gly Ala Ile Met Glu Ser Gly Val 
                245                 250                 255     


Ala Leu Leu Pro Gly Leu Ile Ala Ser Ser Ala Asp Val Ile Ser Thr 
            260                 265                 270         


Val Val Ala Asn Leu Ser Ala Cys Asp Gln Val Asp Ser Glu Ala Leu 
        275                 280                 285             


Val Gly Cys Leu Arg Gly Lys Ser Lys Glu Glu Ile Leu Ala Ile Asn 
    290                 295                 300                 


Lys Pro Phe Lys Met Ile Pro Gly Val Val Asp Gly Val Phe Leu Pro 
305                 310                 315                 320 


Arg His Pro Gln Glu Leu Leu Ala Ser Ala Asp Phe Gln Pro Val Pro 
                325                 330                 335     


Ser Ile Val Gly Val Asn Asn Asn Glu Phe Gly Trp Leu Ile Pro Lys 
            340                 345                 350         


Val Met Arg Ile Tyr Asp Thr Gln Lys Glu Met Asp Arg Glu Ala Ser 
        355                 360                 365             


Gln Ala Ala Leu Gln Lys Met Leu Thr Leu Leu Met Leu Pro Pro Thr 
    370                 375                 380                 


Phe Gly Asp Leu Leu Arg Glu Glu Tyr Ile Gly Asp Asn Gly Asp Pro 
385                 390                 395                 400 


Gln Thr Leu Gln Ala Gln Phe Gln Glu Met Met Ala Asp Ser Met Phe 
                405                 410                 415     


Val Ile Pro Ala Leu Gln Val Ala His Phe Gln Cys Ser Arg Ala Pro 
            420                 425                 430         


Val Tyr Phe Tyr Glu Phe Gln His Gln Pro Ser Trp Leu Lys Asn Ile 
        435                 440                 445             


Arg Pro Pro His Met Lys Ala Asp His Gly Asp Glu Leu Pro Phe Val 
    450                 455                 460                 


Phe Arg Ser Phe Phe Gly Gly Asn Tyr Ile Lys Phe Thr Glu Glu Glu 
465                 470                 475                 480 


Glu Gln Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Asn Phe Ala Arg 
                485                 490                 495     


Asn Gly Asn Pro Asn Gly Glu Gly Leu Pro His Trp Pro Leu Phe Asp 
            500                 505                 510         


Gln Glu Glu Gln Tyr Leu Gln Leu Asn Leu Gln Pro Ala Val Gly Arg 
        515                 520                 525             


Ala Leu Lys Ala His Arg Leu Gln Phe Trp Lys Lys Ala Leu Pro Gln 
    530                 535                 540                 


Lys Ile Gln Glu Leu Glu Glu Pro Glu Glu Arg His Thr Glu Leu 
545                 550                 555                 


<210>  405
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  405
atggaccccg aggacgaagg ggtagcggga gtgatgtctg tggggccgcc ggcggcccgg       60

cttcaggaac cagtgacctt ccgggatgtg gctgtggact ttacccagga ggaatggggg      120

cagctggacc ctacccagag gatcctctac cgtgacgtga tgctggagac ctttggtcac      180

ctgctctcca taggtcctga gcttccgaag cctgaagtca tctcccagct ggagcaaggg      240

accgagctat gggtggctga gagaggaacc acccagggct gccatccagc ctgggagcct      300

cgatctgaaa gccaagcatc acgcaaggaa gagggcctgc ctgaagagga gccatcccat      360

gtcacgggaa gggaaggatt cccgacagat gctccttatc ccaccacgtt agggaaagac      420

agggagtgtc agagccagag tctggcactc aaggagcaga ataacttgaa gcagttggaa      480

tttggcctca aggaagcacc agttcaagat caaggctaca aaactctcag actcagggaa      540

aactgcgtcc tgagttcaag cccaaatcca ttcccagaga tctctagagg ggagtatttg      600

tatacttacg actcacagat tacagactca gaacataact ccagcttagt cagtcagcag      660

acaggctccc caggaaaaca gcccggtgaa aacagtgact gtcacagaga ttccagtcag      720

gccattccaa ttacggaact cacaaaaagc caggtgcagg acaaacccta caaatgtact      780

gactgtggga agtcgtttaa ccataacgca cacctcaccg tgcacaagag gattcatacg      840

ggagaaagac cttatatgtg caaggagtgt gggaaagcct tcagccagaa ctcctccctc      900

gtccagcatg agcgcatcca cactggagac aagccctaca agtgtgccga atgtgggaag      960

tctttctgcc atagtacaca ccttaccgtc catcggagga ttcacactgg ggagaagccc     1020

tatgagtgtc aggactgtgg gagggccttc aaccagaact cctccctggg gcggcacaag     1080

aggacacaca ctggggagaa gccatacacc tgcagtgtgt gtgggaaatc cttctctcgg     1140

accacttgcc ttttcctgca cctgagaact cacaccgagg agaggcccta cgagtgtaac     1200

cactgcggga agggcttcag gcacagctca tccctggccc agcaccagcg gaagcacgcg     1260

ggggagaagc cctttgagtg ccgccagagg ctgatctttg agcagacgcc agctctcaca     1320

aagcatgaat ggacagaagc cctgggctgt gacccacctt tgagtcaaga tgagaggact     1380

caccgaagcg acagaccctt caaatgtaat cagtgtggga agtgtttcat tcagagctct     1440

cacctcatcc ggcaccagat aactcacacc agagaggagc agccccatgg gcgaagccgg     1500

cggcgtgaac aatcctcgag caggaactca cacctggttc agcatcaaca cccgaactcc     1560

agaaagagct ctgcaggcgg agcaaaggca gggcagccgg aaagcagagc cctggctttg     1620

tttgacatcc aaaaaatcat gcaagagaaa aaccctgtgc acgttattgg ggtggaagag     1680

ccttctgtgg gtgcttccat gttatttgac atcagagaat ccacatag                  1728


<210>  406
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Asp Pro Glu Asp Glu Gly Val Ala Gly Val Met Ser Val Gly Pro 
1               5                   10                  15      


Pro Ala Ala Arg Leu Gln Glu Pro Val Thr Phe Arg Asp Val Ala Val 
            20                  25                  30          


Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Pro Thr Gln Arg Ile 
        35                  40                  45              


Leu Tyr Arg Asp Val Met Leu Glu Thr Phe Gly His Leu Leu Ser Ile 
    50                  55                  60                  


Gly Pro Glu Leu Pro Lys Pro Glu Val Ile Ser Gln Leu Glu Gln Gly 
65                  70                  75                  80  


Thr Glu Leu Trp Val Ala Glu Arg Gly Thr Thr Gln Gly Cys His Pro 
                85                  90                  95      


Ala Trp Glu Pro Arg Ser Glu Ser Gln Ala Ser Arg Lys Glu Glu Gly 
            100                 105                 110         


Leu Pro Glu Glu Glu Pro Ser His Val Thr Gly Arg Glu Gly Phe Pro 
        115                 120                 125             


Thr Asp Ala Pro Tyr Pro Thr Thr Leu Gly Lys Asp Arg Glu Cys Gln 
    130                 135                 140                 


Ser Gln Ser Leu Ala Leu Lys Glu Gln Asn Asn Leu Lys Gln Leu Glu 
145                 150                 155                 160 


Phe Gly Leu Lys Glu Ala Pro Val Gln Asp Gln Gly Tyr Lys Thr Leu 
                165                 170                 175     


Arg Leu Arg Glu Asn Cys Val Leu Ser Ser Ser Pro Asn Pro Phe Pro 
            180                 185                 190         


Glu Ile Ser Arg Gly Glu Tyr Leu Tyr Thr Tyr Asp Ser Gln Ile Thr 
        195                 200                 205             


Asp Ser Glu His Asn Ser Ser Leu Val Ser Gln Gln Thr Gly Ser Pro 
    210                 215                 220                 


Gly Lys Gln Pro Gly Glu Asn Ser Asp Cys His Arg Asp Ser Ser Gln 
225                 230                 235                 240 


Ala Ile Pro Ile Thr Glu Leu Thr Lys Ser Gln Val Gln Asp Lys Pro 
                245                 250                 255     


Tyr Lys Cys Thr Asp Cys Gly Lys Ser Phe Asn His Asn Ala His Leu 
            260                 265                 270         


Thr Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Met Cys Lys 
        275                 280                 285             


Glu Cys Gly Lys Ala Phe Ser Gln Asn Ser Ser Leu Val Gln His Glu 
    290                 295                 300                 


Arg Ile His Thr Gly Asp Lys Pro Tyr Lys Cys Ala Glu Cys Gly Lys 
305                 310                 315                 320 


Ser Phe Cys His Ser Thr His Leu Thr Val His Arg Arg Ile His Thr 
                325                 330                 335     


Gly Glu Lys Pro Tyr Glu Cys Gln Asp Cys Gly Arg Ala Phe Asn Gln 
            340                 345                 350         


Asn Ser Ser Leu Gly Arg His Lys Arg Thr His Thr Gly Glu Lys Pro 
        355                 360                 365             


Tyr Thr Cys Ser Val Cys Gly Lys Ser Phe Ser Arg Thr Thr Cys Leu 
    370                 375                 380                 


Phe Leu His Leu Arg Thr His Thr Glu Glu Arg Pro Tyr Glu Cys Asn 
385                 390                 395                 400 


His Cys Gly Lys Gly Phe Arg His Ser Ser Ser Leu Ala Gln His Gln 
                405                 410                 415     


Arg Lys His Ala Gly Glu Lys Pro Phe Glu Cys Arg Gln Arg Leu Ile 
            420                 425                 430         


Phe Glu Gln Thr Pro Ala Leu Thr Lys His Glu Trp Thr Glu Ala Leu 
        435                 440                 445             


Gly Cys Asp Pro Pro Leu Ser Gln Asp Glu Arg Thr His Arg Ser Asp 
    450                 455                 460                 


Arg Pro Phe Lys Cys Asn Gln Cys Gly Lys Cys Phe Ile Gln Ser Ser 
465                 470                 475                 480 


His Leu Ile Arg His Gln Ile Thr His Thr Arg Glu Glu Gln Pro His 
                485                 490                 495     


Gly Arg Ser Arg Arg Arg Glu Gln Ser Ser Ser Arg Asn Ser His Leu 
            500                 505                 510         


Val Gln His Gln His Pro Asn Ser Arg Lys Ser Ser Ala Gly Gly Ala 
        515                 520                 525             


Lys Ala Gly Gln Pro Glu Ser Arg Ala Leu Ala Leu Phe Asp Ile Gln 
    530                 535                 540                 


Lys Ile Met Gln Glu Lys Asn Pro Val His Val Ile Gly Val Glu Glu 
545                 550                 555                 560 


Pro Ser Val Gly Ala Ser Met Leu Phe Asp Ile Arg Glu Ser Thr 
                565                 570                 575 


<210>  407
<211>  2856
<212>  DNA
<213>  Homo sapiens

<400>  407
atgcacaaga ggaaaggacc cccgggaccc ccgggcagag gcgccgcggc cgcccgccag       60

ctgggcctgc tggttgacct ctccccagat ggcctgatga tccctgagga cggggctaac      120

gatgaagaac tggaggctga gttcttggct ttggtcgggg gccagccccc agccctggag      180

aagctcaaag gcaaaggtcc cttgccgatg gaggccattg agaagatggc cagcctgtgc      240

atgagagacc cggatgagga tgaggaggag gggacggatg aggacgactt ggaggctgat      300

gatgacctgc tggcggagct aaatgaggtc cttggagagg agcagaaggc ttcagagacc      360

ccacctcctg tggcccagcc gaagcctgag gcccctcatc cggggctgga gaccaccttg      420

caggagaggc tggcgctcta tcagacagca attgaaagcg ccagacaagc tggagacagc      480

gccaagatgc ggcgctacga tcgggggctt aaaacactgg aaaacctgct cgcctccatc      540

cgtaagggca atgccattga cgaagcggac atcccgccgc cagtggccat aggaaaaggc      600

ccggcgtcca cgcctaccta cagccctgca cccacccagc cggcccctag aatcgcgtca      660

gccccagagc ccagggtcac cctggaggga ccttctgcca ccgccccagc ctcatctcca      720

ggcttggcta agccccagat gcccccaggt ccctgcagcc ctggccctct ggcccagttg      780

cagagccgcc agcgcgacta caagctggct gccctccacg ccaagcagca gggagatacc      840

actgctgccg ctagacactt ccgcgtggct aagagctttg atgctgtctt ggaggccctg      900

agccggggtg agcccgtgga cctctcctgc ctgccccctc cacccgacca gctgccccca      960

gacccaccgt caccaccgtc gcagcctccg acccccgcta cggcgccctc cacaacagag     1020

gtgcccccac ccccgaggac cctgctggag gcgctggagc agcggatgga gcggtaccag     1080

gtggccgcag cccaggccaa gagcaagggg gaccagcgga aagctcgaat gcacgagcgc     1140

atcgtcaagc aataccaaga tgccatccga gcccacaagg ctggccgagc cgtggatgtc     1200

gctgaattgc ccgtgccccc aggcttcccc ccaatccagg gcctggaggc caccaagccc     1260

acccagcaga gtctggtggg tgtcctggag actgccatga agctggccaa ccaggatgaa     1320

ggcccagagg atgaagagga tgaggtgcct aagaagcaga acagccctgt ggcccccaca     1380

gcccagccca aagccccacc ctcaagaact ccccagtcgg gatcagcccc aacagccaaa     1440

gcgcccccca aagccacatc caccagagcc cagcagcagc tggccttcct agagggccgc     1500

aagaagcagc tcctgcaggc cgcactgcga gccaagcaga aaaacgacgt ggagggtgcc     1560

aagatgcacc tgcgccaagc caagggactg gagcctatgc tggaggcctc gcgcaatggg     1620

ctgcctgtgg acatcaccaa ggtgccgcct gcccctgtca acaaggacga ctttgccctg     1680

gtccagcggc ctggcccggg tctgtctcag gaggccgccc ggcgctatgg tgaactcacc     1740

aagctcatac ggcagcagca cgagatgtgc ctgaaccact caaaccaatt cacccagctg     1800

ggcaacatca ctgaaaccac caagtttgaa aagttggcgg aggactgtaa gcggagcatg     1860

gacattctga agcaagcctt cgtccggggt ctccccacgc ccaccgcccg ctttgagcaa     1920

aggaccttca gcgtcatcaa gatcttccct gacctcagca gcaacgacat gctcctcttc     1980

atcgtgaagg gcatcaactt gcccacaccc ccaggactgt cccctggcga tctggatgtc     2040

tttgttcggt ttgacttccc ctatcccaac gtggaagaag ctcagaaaga caagaccagt     2100

gtgatcaaga acacagactc ccctgagttc aaggagcagt tcaaactctg catcaaccgc     2160

agccaccgtg gcttccgaag ggccatccag accaagggca tcaagttcga agtggttcac     2220

aagggggggc tgttcaagac tgaccgggtg ctggggacag cccagctgaa gctggatgca     2280

ctggagatag catgtgaggt ccgggagatc cttgaggtcc tggatggtcg ccggcccaca     2340

ggggggcgac tggaggtaat ggtccggatt cgggagccac tgacagccca gcagttggag     2400

acgacgacag agaggtggct ggtcattgac cctgtgccgg cagctgtgcc cacacaggtt     2460

gctgggccca aagggaaggc ccctcctgtg cctgcccctg caagggagtc agggaacaga     2520

tcagcccggc ccctgcatag cctcagtgtg ctggcgtttg accaagagcg tctggagcgg     2580

aagatcctgg ccctcaggca ggcgcggcgg ccggtgcccc cagaagtggc ccagcagtac     2640

caggacatca tgcaacgcag ccagtggcag agggcacagc tggagcaggg gggtgtgggc     2700

atccgacggg aatacgcagc ccagctggag cggcagctgc agttctacac ggaggctgcc     2760

cggcgcctgg gcaacgatgg cagcagggat gctgcaaagg aggcgctcta taggcggaat     2820

ctggtagaga gtgagctgca gcggctccgc aggtga                               2856


<210>  408
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  408

Met His Lys Arg Lys Gly Pro Pro Gly Pro Pro Gly Arg Gly Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gln Leu Gly Leu Leu Val Asp Leu Ser Pro Asp Gly Leu 
            20                  25                  30          


Met Ile Pro Glu Asp Gly Ala Asn Asp Glu Glu Leu Glu Ala Glu Phe 
        35                  40                  45              


Leu Ala Leu Val Gly Gly Gln Pro Pro Ala Leu Glu Lys Leu Lys Gly 
    50                  55                  60                  


Lys Gly Pro Leu Pro Met Glu Ala Ile Glu Lys Met Ala Ser Leu Cys 
65                  70                  75                  80  


Met Arg Asp Pro Asp Glu Asp Glu Glu Glu Gly Thr Asp Glu Asp Asp 
                85                  90                  95      


Leu Glu Ala Asp Asp Asp Leu Leu Ala Glu Leu Asn Glu Val Leu Gly 
            100                 105                 110         


Glu Glu Gln Lys Ala Ser Glu Thr Pro Pro Pro Val Ala Gln Pro Lys 
        115                 120                 125             


Pro Glu Ala Pro His Pro Gly Leu Glu Thr Thr Leu Gln Glu Arg Leu 
    130                 135                 140                 


Ala Leu Tyr Gln Thr Ala Ile Glu Ser Ala Arg Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Ala Lys Met Arg Arg Tyr Asp Arg Gly Leu Lys Thr Leu Glu Asn Leu 
                165                 170                 175     


Leu Ala Ser Ile Arg Lys Gly Asn Ala Ile Asp Glu Ala Asp Ile Pro 
            180                 185                 190         


Pro Pro Val Ala Ile Gly Lys Gly Pro Ala Ser Thr Pro Thr Tyr Ser 
        195                 200                 205             


Pro Ala Pro Thr Gln Pro Ala Pro Arg Ile Ala Ser Ala Pro Glu Pro 
    210                 215                 220                 


Arg Val Thr Leu Glu Gly Pro Ser Ala Thr Ala Pro Ala Ser Ser Pro 
225                 230                 235                 240 


Gly Leu Ala Lys Pro Gln Met Pro Pro Gly Pro Cys Ser Pro Gly Pro 
                245                 250                 255     


Leu Ala Gln Leu Gln Ser Arg Gln Arg Asp Tyr Lys Leu Ala Ala Leu 
            260                 265                 270         


His Ala Lys Gln Gln Gly Asp Thr Thr Ala Ala Ala Arg His Phe Arg 
        275                 280                 285             


Val Ala Lys Ser Phe Asp Ala Val Leu Glu Ala Leu Ser Arg Gly Glu 
    290                 295                 300                 


Pro Val Asp Leu Ser Cys Leu Pro Pro Pro Pro Asp Gln Leu Pro Pro 
305                 310                 315                 320 


Asp Pro Pro Ser Pro Pro Ser Gln Pro Pro Thr Pro Ala Thr Ala Pro 
                325                 330                 335     


Ser Thr Thr Glu Val Pro Pro Pro Pro Arg Thr Leu Leu Glu Ala Leu 
            340                 345                 350         


Glu Gln Arg Met Glu Arg Tyr Gln Val Ala Ala Ala Gln Ala Lys Ser 
        355                 360                 365             


Lys Gly Asp Gln Arg Lys Ala Arg Met His Glu Arg Ile Val Lys Gln 
    370                 375                 380                 


Tyr Gln Asp Ala Ile Arg Ala His Lys Ala Gly Arg Ala Val Asp Val 
385                 390                 395                 400 


Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Gln Gly Leu Glu 
                405                 410                 415     


Ala Thr Lys Pro Thr Gln Gln Ser Leu Val Gly Val Leu Glu Thr Ala 
            420                 425                 430         


Met Lys Leu Ala Asn Gln Asp Glu Gly Pro Glu Asp Glu Glu Asp Glu 
        435                 440                 445             


Val Pro Lys Lys Gln Asn Ser Pro Val Ala Pro Thr Ala Gln Pro Lys 
    450                 455                 460                 


Ala Pro Pro Ser Arg Thr Pro Gln Ser Gly Ser Ala Pro Thr Ala Lys 
465                 470                 475                 480 


Ala Pro Pro Lys Ala Thr Ser Thr Arg Ala Gln Gln Gln Leu Ala Phe 
                485                 490                 495     


Leu Glu Gly Arg Lys Lys Gln Leu Leu Gln Ala Ala Leu Arg Ala Lys 
            500                 505                 510         


Gln Lys Asn Asp Val Glu Gly Ala Lys Met His Leu Arg Gln Ala Lys 
        515                 520                 525             


Gly Leu Glu Pro Met Leu Glu Ala Ser Arg Asn Gly Leu Pro Val Asp 
    530                 535                 540                 


Ile Thr Lys Val Pro Pro Ala Pro Val Asn Lys Asp Asp Phe Ala Leu 
545                 550                 555                 560 


Val Gln Arg Pro Gly Pro Gly Leu Ser Gln Glu Ala Ala Arg Arg Tyr 
                565                 570                 575     


Gly Glu Leu Thr Lys Leu Ile Arg Gln Gln His Glu Met Cys Leu Asn 
            580                 585                 590         


His Ser Asn Gln Phe Thr Gln Leu Gly Asn Ile Thr Glu Thr Thr Lys 
        595                 600                 605             


Phe Glu Lys Leu Ala Glu Asp Cys Lys Arg Ser Met Asp Ile Leu Lys 
    610                 615                 620                 


Gln Ala Phe Val Arg Gly Leu Pro Thr Pro Thr Ala Arg Phe Glu Gln 
625                 630                 635                 640 


Arg Thr Phe Ser Val Ile Lys Ile Phe Pro Asp Leu Ser Ser Asn Asp 
                645                 650                 655     


Met Leu Leu Phe Ile Val Lys Gly Ile Asn Leu Pro Thr Pro Pro Gly 
            660                 665                 670         


Leu Ser Pro Gly Asp Leu Asp Val Phe Val Arg Phe Asp Phe Pro Tyr 
        675                 680                 685             


Pro Asn Val Glu Glu Ala Gln Lys Asp Lys Thr Ser Val Ile Lys Asn 
    690                 695                 700                 


Thr Asp Ser Pro Glu Phe Lys Glu Gln Phe Lys Leu Cys Ile Asn Arg 
705                 710                 715                 720 


Ser His Arg Gly Phe Arg Arg Ala Ile Gln Thr Lys Gly Ile Lys Phe 
                725                 730                 735     


Glu Val Val His Lys Gly Gly Leu Phe Lys Thr Asp Arg Val Leu Gly 
            740                 745                 750         


Thr Ala Gln Leu Lys Leu Asp Ala Leu Glu Ile Ala Cys Glu Val Arg 
        755                 760                 765             


Glu Ile Leu Glu Val Leu Asp Gly Arg Arg Pro Thr Gly Gly Arg Leu 
    770                 775                 780                 


Glu Val Met Val Arg Ile Arg Glu Pro Leu Thr Ala Gln Gln Leu Glu 
785                 790                 795                 800 


Thr Thr Thr Glu Arg Trp Leu Val Ile Asp Pro Val Pro Ala Ala Val 
                805                 810                 815     


Pro Thr Gln Val Ala Gly Pro Lys Gly Lys Ala Pro Pro Val Pro Ala 
            820                 825                 830         


Pro Ala Arg Glu Ser Gly Asn Arg Ser Ala Arg Pro Leu His Ser Leu 
        835                 840                 845             


Ser Val Leu Ala Phe Asp Gln Glu Arg Leu Glu Arg Lys Ile Leu Ala 
    850                 855                 860                 


Leu Arg Gln Ala Arg Arg Pro Val Pro Pro Glu Val Ala Gln Gln Tyr 
865                 870                 875                 880 


Gln Asp Ile Met Gln Arg Ser Gln Trp Gln Arg Ala Gln Leu Glu Gln 
                885                 890                 895     


Gly Gly Val Gly Ile Arg Arg Glu Tyr Ala Ala Gln Leu Glu Arg Gln 
            900                 905                 910         


Leu Gln Phe Tyr Thr Glu Ala Ala Arg Arg Leu Gly Asn Asp Gly Ser 
        915                 920                 925             


Arg Asp Ala Ala Lys Glu Ala Leu Tyr Arg Arg Asn Leu Val Glu Ser 
    930                 935                 940                 


Glu Leu Gln Arg Leu Arg Arg 
945                 950     


<210>  409
<211>  5808
<212>  DNA
<213>  Homo sapiens

<400>  409
atgcagtttg tatcctgggc cacactgcta acgctcctgg tgcgggacct ggccgagatg       60

gggagcccag acgccgcggc ggccgtgcgc aaggacaggc tgcacccgag gcaagtgaaa      120

ttattagaga ccctgagcga atacgaaatc gtgtctccca tccgagtgaa cgctctcgga      180

gaaccctttc ccacgaacgt ccacttcaaa agaacgcgac ggagcattaa ctctgccact      240

gacccctggc ctgccttcgc ctcctcctct tcctcctcta cctcctccca ggcgcattac      300

cgcctctctg ccttcggcca gcagtttcta tttaatctca ccgccaatgc cggatttatc      360

gctccactgt tcactgtcac cctcctcggg acgcccgggg tgaatcagac caagttttat      420

tccgaagagg aagcggaact caagcactgt ttctacaaag gctatgtcaa taccaactcc      480

gagcacacgg ccgtcatcag cctctgctca ggaatgctgg gcacattccg gtctcatgat      540

ggggattatt ttattgaacc actacagtct atggatgaac aagaagatga agaggaacaa      600

aacaaacccc acatcattta taggcgcagc gccccccaga gagagccctc aacaggaagg      660

catgcatgtg acacctcaga acacaaaaat aggcacagta aagacaagaa gaaaaccaga      720

gcaagaaaat ggggagaaag gattaacctg gctggtgacg tagcagcatt aaacagcggc      780

ttagcaacag aggcattttc tgcttatggt aataagacgg acaacacaag agaaaagagg      840

acccacagaa ggacaaaacg ttttttatcc tatccacggt ttgtagaagt cttggtggtg      900

gcagacaaca gaatggtttc ataccatgga gaaaaccttc aacactatat tttaacttta      960

atgtcaattg tagcctctat ctataaagac ccaagtattg gaaatttaat taatattgtt     1020

attgtgaact taattgtgat tcataatgaa caggatgggc cttccatatc ttttaatgct     1080

cagacaacat taaaaaactt ttgccagtgg cagcattcga agaacagtcc aggtggaatc     1140

catcatgata ctgctgttct cttaacaaga caggatatct gcagagctca cgacaaatgt     1200

gataccttag gcctggctga actgggaacc atttgtgatc cctatagaag ctgttctatt     1260

agtgaagata gtggattgag tacagctttt acgatcgccc atgagctggg ccatgtgttt     1320

aacatgcctc atgatgacaa caacaaatgt aaagaagaag gagttaagag tccccagcat     1380

gtcatggctc caacactgaa cttctacacc aacccctgga tgtggtcaaa gtgtagtcga     1440

aaatatatca ctgagttttt agacactggt tatggcgagt gtttgcttaa cgaacctgaa     1500

tccagaccct accctttgcc tgtccaactg ccaggcatcc tttacaacgt gaataaacaa     1560

tgtgaattga tttttggacc aggttctcag gtgtgcccat atatgatgca gtgcagacgg     1620

ctctggtgca ataacgtcaa tggagtacac aaaggctgcc ggactcagca cacaccctgg     1680

gccgatggga cggagtgcga gcctggaaag cactgcaagt atggattttg tgttcccaaa     1740

gaaatggatg tccccgtgac agatggatcc tggggaagtt ggagtccctt tggaacctgc     1800

tccagaacat gtggaggggg catcaaaaca gccattcgag agtgcaacag accagaacca     1860

aaaaatggtg gaaaatactg tgtaggacgt agaatgaaat ttaagtcctg caacacggag     1920

ccatgtctca agcagaagcg agacttccga gatgaacagt gtgctcactt tgacgggaag     1980

cattttaaca tcaacggtct gcttcccaat gtgcgctggg tccctaaata cagtggaatt     2040

ctgatgaagg accggtgcaa gttgttctgc agagtggcag ggaacacagc ctactatcag     2100

cttcgagaca gagtgataga tggaactcct tgtggccagg acacaaatga tatctgtgtc     2160

cagggccttt gccggcaagc tggatgcgat catgttttaa actcaaaagc ccggagagat     2220

aaatgtgggg tttgtggtgg cgataattct tcatgcaaaa cagtggcagg aacatttaat     2280

acagtacatt atggttacaa tactgtggtc cgaattccag ctggtgctac caatattgat     2340

gtgcggcagc acagtttctc aggggaaaca gacgatgaca actacttagc tttatcaagc     2400

agtaaaggtg aattcttgct aaatggaaac tttgttgtca caatggccaa aagggaaatt     2460

cgcattggga atgctgtggt agagtacagt gggtccgaga ctgccgtaga aagaattaac     2520

tcaacagatc gcattgagca agaacttttg cttcaggttt tgtcggtggg aaagttgtac     2580

aaccccgatg tacgctattc tttcaatatt ccaattgaag ataaacctca gcagttttac     2640

tggaacagtc atgggccatg gcaagcatgc agtaaaccct gccaagggga acggaaacga     2700

aaacttgttt gcaccaggga atctgatcag cttactgttt ctgatcaaag atgcgatcgg     2760

ctgccccagc ctggacacat tactgaaccc tgtggtacag actgtgacct gaggtggcat     2820

gttgccagca ggagtgaatg tagtgcccag tgtggcttgg gttaccgcac attggacatc     2880

tactgtgcca aatatagcag gctggatggg aagactgaga aggttgatga tggtttttgc     2940

agcagccatc ccaaaccaag caaccgtgaa aaatgctcag gggaatgtaa cacgggtggc     3000

tggcgctatt ctgcctggac tgaatgttca aaaagctgtg acggtgggac ccagaggaga     3060

agggctattt gtgtcaatac ccgaaatgat gtactggatg acagcaaatg cacacatcaa     3120

gagaaagtta ccattcagag gtgcagtgag ttcccttgtc cacagtggaa atctggagac     3180

tggtcagagt gcttggtcac ctgtggaaaa gggcataagc accgccaggt ctggtgtcag     3240

tttggtgaag atcgattaaa tgatagaatg tgtgaccctg agaccaagcc aacatctatg     3300

cagacttgtc agcagccgga atgtgcatcc tggcaggcgg gtccctgggg acagtgcagt     3360

gtcacttgtg gacagggata ccagctaaga gcagtgaaat gcatcattgg gacttatatg     3420

tcagtggtag atgacaatga ctgtaatgca gcaactagac caactgatac ccaggactgt     3480

gaattaccat catgtcatcc tcccccagct gccccggaaa cgaggagaag cacatacagt     3540

gcaccaagaa cccagtggcg atttgggtct tggaccccat gctcagccac ttgtgggaaa     3600

ggtacccgga tgagatacgt cagctgccga gatgagaatg gctctgtggc tgacgagagt     3660

gcctgtgcta ccctgcctag accagtggca aaggaagaat gttctgtgac accctgtggg     3720

caatggaagg ccttggactg gagctcttgc tctgtgacct gtgggcaagg tagggcaacc     3780

cggcaagtga tgtgtgtcaa ctacagtgac cacgtgatcg atcggagtga gtgtgaccag     3840

gattatatcc cagaaactga ccaggactgt tccatgtcac catgccctca aaggacccca     3900

gacagtggct tagctcagca ccccttccaa aatgaggact atcgtccccg gagcgccagc     3960

cccagccgca cccatgtgct cggtggaaac cagtggagaa ctggcccctg gggagcatgt     4020

tccagtacct gtgctggcgg atcccagcgg cgtgttgttg tatgtcagga tgaaaatgga     4080

tacaccgcaa acgactgtgt ggagagaata aaacctgatg agcaaagagc ctgtgaatcc     4140

ggcccttgtc ctcagtgggc ttatggcaac tggggagagt gcactaagct gtgtggtgga     4200

ggcataagaa caagactggt ggtctgtcag cggtccaacg gtgaacggtt tccagatttg     4260

agctgtgaaa ttcttgataa acctcccgat cgtgagcagt gtaacacaca tgcttgtcca     4320

cacgacgctg catggagtac tggcccttgg agctcgtgtt ctgtctcttg tggtcgaggg     4380

cataaacaac gaaatgttta ctgcatggca aaagatggaa gccatttaga aagtgattac     4440

tgtaagcacc tggctaagcc acatgggcac agaaagtgcc gaggaggaag atgccccaaa     4500

tggaaagctg gcgcttggag tcagtgctct gtgtcctgtg gccgaggcgt acagcagagg     4560

catgtgggct gtcagatcgg aacacacaaa atagccagag agaccgagtg caacccatac     4620

accagaccgg agtcggaacg cgactgccaa ggcccacggt gtcccctcta cacttggagg     4680

gcagaggaat ggcaagaatg caccaagacc tgcggcgaag gctccaggta ccgcaaggtg     4740

gtgtgtgtgg atgacaacaa aaacgaggtg catggggcac gctgtgacgt gagcaagcgg     4800

ccggtggacc gtgaaagctg tagtttgcaa ccctgcgagt atgtctggat cacaggagaa     4860

tggtcagagt gctcagtgac ctgtggaaaa ggctacaaac aaaggcttgt ctcgtgcagc     4920

gagatttaca ccgggaagga gaattatgaa tacagctacc aaaccaccat caactgccca     4980

ggcacgcagc cccccagtgt tcacccctgt tacctgaggg actgccctgt ctcggccacc     5040

tggagagttg gcaactgggg gagctgctca gtgtcttgtg gtgttggagt gatgcagaga     5100

tctgtgcaat gtttaaccaa tgaggaccaa cccagccact tatgccacac tgatctgaag     5160

ccagaagaac gaaaaacctg ccgtaatgtc tataactgtg agttacccca gaattgcaag     5220

gaggtaaaaa gacttaaagg tgccagtgaa gatggtgaat atttcctgat gattagagga     5280

aagcttctga agatattctg tgcggggatg cactctgacc accccaaaga gtacgtgaca     5340

ctggtgcatg gagactctga gaatttctcc gaggtttatg ggcacaggtt acacaaccca     5400

acagaatgtc cctataacgg gagccggcgc gatgactgcc aatgtcggaa ggattacacg     5460

gccgctgggt tttccagttt tcagaaaatc agaatagacc tgaccagcat gcagataatc     5520

accactgact tacagtttgc aaggacaagc gaaggacatc ccgtcccttt tgccacagcc     5580

ggggattgct acagcgctgc caagtgccca cagggtcgtt ttagcatcaa cctttatgga     5640

accggcttgt ctttaactga atctgccaga tggatatcac aagggaatta tgctgtctct     5700

gacatcaaga agtcgccgga tggtacccga gtcgtaggga aatgcggtgg ttactgtgga     5760

aaatgcactc catcctctgg tactggcctg gaggtgcgag ttttatag                  5808


<210>  410
<211>  1935
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu 
                325                 330                 335     


Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp 
            340                 345                 350         


Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys 
        355                 360                 365             


Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr 
    370                 375                 380                 


Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys 
385                 390                 395                 400 


Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg 
                405                 410                 415     


Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile 
            420                 425                 430         


Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn 
        435                 440                 445             


Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro 
    450                 455                 460                 


Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg 
465                 470                 475                 480 


Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
                485                 490                 495     


Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly 
            500                 505                 510         


Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly 
        515                 520                 525             


Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn 
    530                 535                 540                 


Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp 
545                 550                 555                 560 


Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe 
                565                 570                 575     


Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly 
            580                 585                 590         


Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile 
        595                 600                 605             


Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly 
    610                 615                 620                 


Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu 
625                 630                 635                 640 


Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His 
                645                 650                 655     


Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg 
            660                 665                 670         


Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu 
        675                 680                 685             


Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg 
    690                 695                 700                 


Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val 
705                 710                 715                 720 


Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys 
                725                 730                 735     


Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
            740                 745                 750         


Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr 
        755                 760                 765             


Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His 
    770                 775                 780                 


Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser 
785                 790                 795                 800 


Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala 
                805                 810                 815     


Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser 
            820                 825                 830         


Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu 
        835                 840                 845             


Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val 
    850                 855                 860                 


Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr 
865                 870                 875                 880 


Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly 
                885                 890                 895     


Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr 
            900                 905                 910         


Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr 
        915                 920                 925             


Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg 
    930                 935                 940                 


Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile 
945                 950                 955                 960 


Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp 
                965                 970                 975     


Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys 
            980                 985                 990         


Ser Gly Glu Cys Asn Thr Gly Gly  Trp Arg Tyr Ser Ala  Trp Thr Glu 
        995                 1000                 1005             


Cys Ser  Lys Ser Cys Asp Gly  Gly Thr Gln Arg Arg  Arg Ala Ile 
    1010                 1015                 1020             


Cys Val  Asn Thr Arg Asn Asp  Val Leu Asp Asp Ser  Lys Cys Thr 
    1025                 1030                 1035             


His Gln  Glu Lys Val Thr Ile  Gln Arg Cys Ser Glu  Phe Pro Cys 
    1040                 1045                 1050             


Pro Gln  Trp Lys Ser Gly Asp  Trp Ser Glu Cys Leu  Val Thr Cys 
    1055                 1060                 1065             


Gly Lys  Gly His Lys His Arg  Gln Val Trp Cys Gln  Phe Gly Glu 
    1070                 1075                 1080             


Asp Arg  Leu Asn Asp Arg Met  Cys Asp Pro Glu Thr  Lys Pro Thr 
    1085                 1090                 1095             


Ser Met  Gln Thr Cys Gln Gln  Pro Glu Cys Ala Ser  Trp Gln Ala 
    1100                 1105                 1110             


Gly Pro  Trp Gly Gln Cys Ser  Val Thr Cys Gly Gln  Gly Tyr Gln 
    1115                 1120                 1125             


Leu Arg  Ala Val Lys Cys Ile  Ile Gly Thr Tyr Met  Ser Val Val 
    1130                 1135                 1140             


Asp Asp  Asn Asp Cys Asn Ala  Ala Thr Arg Pro Thr  Asp Thr Gln 
    1145                 1150                 1155             


Asp Cys  Glu Leu Pro Ser Cys  His Pro Pro Pro Ala  Ala Pro Glu 
    1160                 1165                 1170             


Thr Arg  Arg Ser Thr Tyr Ser  Ala Pro Arg Thr Gln  Trp Arg Phe 
    1175                 1180                 1185             


Gly Ser  Trp Thr Pro Cys Ser  Ala Thr Cys Gly Lys  Gly Thr Arg 
    1190                 1195                 1200             


Met Arg  Tyr Val Ser Cys Arg  Asp Glu Asn Gly Ser  Val Ala Asp 
    1205                 1210                 1215             


Glu Ser  Ala Cys Ala Thr Leu  Pro Arg Pro Val Ala  Lys Glu Glu 
    1220                 1225                 1230             


Cys Ser  Val Thr Pro Cys Gly  Gln Trp Lys Ala Leu  Asp Trp Ser 
    1235                 1240                 1245             


Ser Cys  Ser Val Thr Cys Gly  Gln Gly Arg Ala Thr  Arg Gln Val 
    1250                 1255                 1260             


Met Cys  Val Asn Tyr Ser Asp  His Val Ile Asp Arg  Ser Glu Cys 
    1265                 1270                 1275             


Asp Gln  Asp Tyr Ile Pro Glu  Thr Asp Gln Asp Cys  Ser Met Ser 
    1280                 1285                 1290             


Pro Cys  Pro Gln Arg Thr Pro  Asp Ser Gly Leu Ala  Gln His Pro 
    1295                 1300                 1305             


Phe Gln  Asn Glu Asp Tyr Arg  Pro Arg Ser Ala Ser  Pro Ser Arg 
    1310                 1315                 1320             


Thr His  Val Leu Gly Gly Asn  Gln Trp Arg Thr Gly  Pro Trp Gly 
    1325                 1330                 1335             


Ala Cys  Ser Ser Thr Cys Ala  Gly Gly Ser Gln Arg  Arg Val Val 
    1340                 1345                 1350             


Val Cys  Gln Asp Glu Asn Gly  Tyr Thr Ala Asn Asp  Cys Val Glu 
    1355                 1360                 1365             


Arg Ile  Lys Pro Asp Glu Gln  Arg Ala Cys Glu Ser  Gly Pro Cys 
    1370                 1375                 1380             


Pro Gln  Trp Ala Tyr Gly Asn  Trp Gly Glu Cys Thr  Lys Leu Cys 
    1385                 1390                 1395             


Gly Gly  Gly Ile Arg Thr Arg  Leu Val Val Cys Gln  Arg Ser Asn 
    1400                 1405                 1410             


Gly Glu  Arg Phe Pro Asp Leu  Ser Cys Glu Ile Leu  Asp Lys Pro 
    1415                 1420                 1425             


Pro Asp  Arg Glu Gln Cys Asn  Thr His Ala Cys Pro  His Asp Ala 
    1430                 1435                 1440             


Ala Trp  Ser Thr Gly Pro Trp  Ser Ser Cys Ser Val  Ser Cys Gly 
    1445                 1450                 1455             


Arg Gly  His Lys Gln Arg Asn  Val Tyr Cys Met Ala  Lys Asp Gly 
    1460                 1465                 1470             


Ser His  Leu Glu Ser Asp Tyr  Cys Lys His Leu Ala  Lys Pro His 
    1475                 1480                 1485             


Gly His  Arg Lys Cys Arg Gly  Gly Arg Cys Pro Lys  Trp Lys Ala 
    1490                 1495                 1500             


Gly Ala  Trp Ser Gln Cys Ser  Val Ser Cys Gly Arg  Gly Val Gln 
    1505                 1510                 1515             


Gln Arg  His Val Gly Cys Gln  Ile Gly Thr His Lys  Ile Ala Arg 
    1520                 1525                 1530             


Glu Thr  Glu Cys Asn Pro Tyr  Thr Arg Pro Glu Ser  Glu Arg Asp 
    1535                 1540                 1545             


Cys Gln  Gly Pro Arg Cys Pro  Leu Tyr Thr Trp Arg  Ala Glu Glu 
    1550                 1555                 1560             


Trp Gln  Glu Cys Thr Lys Thr  Cys Gly Glu Gly Ser  Arg Tyr Arg 
    1565                 1570                 1575             


Lys Val  Val Cys Val Asp Asp  Asn Lys Asn Glu Val  His Gly Ala 
    1580                 1585                 1590             


Arg Cys  Asp Val Ser Lys Arg  Pro Val Asp Arg Glu  Ser Cys Ser 
    1595                 1600                 1605             


Leu Gln  Pro Cys Glu Tyr Val  Trp Ile Thr Gly Glu  Trp Ser Glu 
    1610                 1615                 1620             


Cys Ser  Val Thr Cys Gly Lys  Gly Tyr Lys Gln Arg  Leu Val Ser 
    1625                 1630                 1635             


Cys Ser  Glu Ile Tyr Thr Gly  Lys Glu Asn Tyr Glu  Tyr Ser Tyr 
    1640                 1645                 1650             


Gln Thr  Thr Ile Asn Cys Pro  Gly Thr Gln Pro Pro  Ser Val His 
    1655                 1660                 1665             


Pro Cys  Tyr Leu Arg Asp Cys  Pro Val Ser Ala Thr  Trp Arg Val 
    1670                 1675                 1680             


Gly Asn  Trp Gly Ser Cys Ser  Val Ser Cys Gly Val  Gly Val Met 
    1685                 1690                 1695             


Gln Arg  Ser Val Gln Cys Leu  Thr Asn Glu Asp Gln  Pro Ser His 
    1700                 1705                 1710             


Leu Cys  His Thr Asp Leu Lys  Pro Glu Glu Arg Lys  Thr Cys Arg 
    1715                 1720                 1725             


Asn Val  Tyr Asn Cys Glu Leu  Pro Gln Asn Cys Lys  Glu Val Lys 
    1730                 1735                 1740             


Arg Leu  Lys Gly Ala Ser Glu  Asp Gly Glu Tyr Phe  Leu Met Ile 
    1745                 1750                 1755             


Arg Gly  Lys Leu Leu Lys Ile  Phe Cys Ala Gly Met  His Ser Asp 
    1760                 1765                 1770             


His Pro  Lys Glu Tyr Val Thr  Leu Val His Gly Asp  Ser Glu Asn 
    1775                 1780                 1785             


Phe Ser  Glu Val Tyr Gly His  Arg Leu His Asn Pro  Thr Glu Cys 
    1790                 1795                 1800             


Pro Tyr  Asn Gly Ser Arg Arg  Asp Asp Cys Gln Cys  Arg Lys Asp 
    1805                 1810                 1815             


Tyr Thr  Ala Ala Gly Phe Ser  Ser Phe Gln Lys Ile  Arg Ile Asp 
    1820                 1825                 1830             


Leu Thr  Ser Met Gln Ile Ile  Thr Thr Asp Leu Gln  Phe Ala Arg 
    1835                 1840                 1845             


Thr Ser  Glu Gly His Pro Val  Pro Phe Ala Thr Ala  Gly Asp Cys 
    1850                 1855                 1860             


Tyr Ser  Ala Ala Lys Cys Pro  Gln Gly Arg Phe Ser  Ile Asn Leu 
    1865                 1870                 1875             


Tyr Gly  Thr Gly Leu Ser Leu  Thr Glu Ser Ala Arg  Trp Ile Ser 
    1880                 1885                 1890             


Gln Gly  Asn Tyr Ala Val Ser  Asp Ile Lys Lys Ser  Pro Asp Gly 
    1895                 1900                 1905             


Thr Arg  Val Val Gly Lys Cys  Gly Gly Tyr Cys Gly  Lys Cys Thr 
    1910                 1915                 1920             


Pro Ser  Ser Gly Thr Gly Leu  Glu Val Arg Val Leu  
    1925                 1930                 1935 


<210>  411
<211>  2853
<212>  DNA
<213>  Homo sapiens

<400>  411
atgacatgga gaatgggacc ccgtttcact atgctgttgg ccatgtggct agtgtgtgga       60

tcagaacccc acccccatgc cactattaga ggcagccacg gaggacggaa agtgcctttg      120

gtttctccgg acagcagtag gccagctcgg tttctgaggc acactgggag gtctcgcgga      180

attgagagat ccactctgga ggaaccaaac cttcagcctc tccagagaag gaggagtgtg      240

cccgtgttga gactagctcg cccaacagag ccgccagccc gctcggacat caatggggcc      300

gccgtgagac ctgagcaaag accagcagcc aggggctctc cgcgtgagat gatcagagat      360

gaggggtcct cagctcggtc aagaatgttg cgtttccctt cggggtccag ctctcccaac      420

atccttgcca gctttgcagg gaagaacaga gtatgggtca tctcagcccc tcatgcctcg      480

gaaggctact accgcctcat gatgagcctg ctgaaggacg atgtgtactg tgagctggcg      540

gagaggcaca tccaacagat tgtgctcttc caccaggcag gtgaggaagg aggcaaggtg      600

agaaggatca ccagcgaggg ccagatcctg gagcagcccc tggaccctag cctcatccct      660

aagctgatga gcttcctgaa gctggagaag ggcaagtttg gcatggtgct gctgaagaag      720

acgctgcagg tggaggagcg ctatccatat cccgttaggc tggaagccat gtacgaggtc      780

atcgaccaag gccccatccg taggatcgag aagatcaggc agaagggctt tgtccagaaa      840

tgtaaggcct ctggtgtaga gggccaggtg gtggcggagg ggaatgacgg tggaggggga      900

gcaggaaggc caagcctggg cagcgagaag aagaaagagg acccaaggag agcacaagtc      960

ccaccaacca gagagagtcg ggtgaaggtc ctgagaaaac tggccgccac tgcaccagct     1020

ttgccccaac ctccctcaac ccccagagcc accacccttc ctcctgcccc agccacaaca     1080

gtgactcggt ccacgtcccg ggcggtaaca gttgctgcaa gacctatgac caccactgcc     1140

tttcccacca cgcagaggcc ctggaccccc tcaccctccc acaggccccc tacaaccact     1200

gaggtgatca ctgccaggag accctcagtt tcagagaatc tttaccctcc atcccggaag     1260

gatcagcaca gggagaggcc acagacaacc aggaggccca gcaaggccac cagcttggag     1320

agcttcacaa atgcccctcc caccaccatc tcagaaccca gcacaagggc tgctggccca     1380

ggccgtttcc gggacaaccg catggacagg cgggaacatg gccaccgaga cccaaatgtg     1440

gtgccaggtc ctcccaagcc agcaaaggag aaacctccca aaaagaaggc ccaggacaaa     1500

attcttagta atgagtatga ggagaagtat gacctcagcc ggcctactgc ctctcagctg     1560

gaggacgagc tgcaggtggg gaatgttccc cttaaaaaag caaaggagtc taaaaagcat     1620

gaaaagcttg agaaaccaga gaaggagaag aaaaaaaaga tgaagaatga gaacgcagac     1680

aagttactta agagtgaaaa gcaaatgaag aagtctgaga aaaagagcaa gcaagagaaa     1740

gagaagagca agaagaaaaa aggaggtaaa acagaacagg atggctatca gaaacccacc     1800

aacaaacact tcacgcagag tcccaagaag tcagtggccg acctgctggg gtcctttgaa     1860

ggcaaacgaa gactccttct gatcactgct cccaaggctg agaacaatat gtatgtgcaa     1920

caacgtgatg aatatctgga aagtttctgc aagatggcta ccaggaaaat ctctgtgatc     1980

accatcttcg gccctgtcaa caacagcacc atgaaaatcg accactttca gctagataat     2040

gagaagccca tgcgagtggt ggatgatgaa gacttggtag accagcgtct catcagcgag     2100

ctgaggaaag agtacggaat gacctacaat gacttcttca tggtgctaac agatgtggat     2160

ctgagagtca agcaatacta tgaggtacca ataacaatga agtctgtgtt tgatctgatc     2220

gatactttcc agtcccgaat caaagatatg gagaagcaga agaaggaggg cattgtttgc     2280

aaagaggaca aaaagcagtc cctggagaac ttcctatcca ggttccggtg gaggaggagg     2340

ttgctggtga tctctgctcc taacgatgaa gactgggcct attcacagca gctctctgcc     2400

ctcagtggtc aggcgtgcaa ttttggtctg cgccacataa ccattctgaa gcttttaggc     2460

gttggagagg aagttggggg agtgttagaa ctgttcccaa ttaatgggag ctctgttgtt     2520

gagcgagaag acgtaccagc ccatttggtg aaagacattc gtaactattt tcaagtgagc     2580

ccggagtact tctccatgct tctagtcgga aaagacggaa atgtcaaatc ctggtatcct     2640

tccccaatgt ggtccatggt gattgtgtac gatttaattg attcgatgca acttcggaga     2700

caggaaatgg cgattcagca gtcactgggg atgcgctgcc cagaagatga gtatgcaggc     2760

tatggttacc atagttacca ccaaggatac caggatggtt accaggatga ctaccgtcat     2820

catgagagtt atcaccatgg atacccttac tga                                  2853


<210>  412
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  413
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  413
gacatccaga tgacccagtc cccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatcgacggt gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg cgacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttc                   348


<210>  414
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  414

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Asp Gly Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe 
        115     


<210>  415
<211>  3036
<212>  DNA
<213>  Homo sapiens

<400>  415
atggtcgctg cgcacgctgc ccattcttcc tcctctgccg agtggatcgc ctgcctggat       60

aaaagaccac tggagcgatc cagcgaagat gtggatataa tcttcactcg actgaaagaa      120

gttaaagctt ttgagaaatt tcacccaaat ctccttcatc agatttgctt atgtggttat      180

tatgagaatc tggaaaaggg aataacatta tttcgccagg gtgatattgg aacaaactgg      240

tatgctgtcc tggcagggtc tttggatgtt aaagtatctg agaccagcag tcaccaggat      300

gctgtgacca tctgtaccct gggaattggg acggcctttg gagagtccat tctggacaac      360

acaccccgcc atgcaaccat cgttaccagg gagagcagtg aactgctccg catcgagcag      420

aaggacttca aggcactatg ggagaaatat cgacagtata tggcaggact tctggctcct      480

ccttatggtg ttatggaaac gggctctaac aatgacagga ttcctgacaa ggagaacaca      540

cctctcattg aacctcacgt tcctcttcgt cctgctaaca ccattaccaa ggtcccttca      600

gagaagatcc tcagagctgg aaaaatttta cgaaatgcca ttctctctcg agcacctcac      660

atgataagag atagaaaata ccacctaaag acatacagac aatgctgtgt gggaactgaa      720

ctggtggact ggatgatgca gcagacacca tgtgttcact cccggactca agctgttggc      780

atgtggcaag tcctgttaga agatggtgtt ctcaaccacg tggaccagga gcaccatttc      840

caagacaaat atttattcta tcgatttctg gatgatgagc acgaggatgc ccctttgcct      900

actgaggagg agaagaagga gtgtgatgag gagctccagg acaccatgct gctgctgtca      960

cagatgggcc ccgacgccca catgaggatg atccttcgca aaccacctgg ccagaggact     1020

gtggatgacc tagagattat ctatgaggag cttcttcata ttaaagcctt atcccatctt     1080

tctaccacag tgaaacgaga gttagcaggt gttctcattt ttgagtctca cgccaaagga     1140

gggactgtgt tgtttaacca gggggaagaa ggtacctcct ggtacattat tctaaaagga     1200

tcagtgaatg tagtcattta cggcaagggt gtggtctgca ccctgcatga aggagatgac     1260

ttcggcaagt tagcactagt gaatgatgcc ccacgagctg cctctatcgt cttacgagaa     1320

gataactgcc atttcttaag agtagacaag gaggatttca accggatcct aagggacgtg     1380

gaggcgaata cagtcagact taaagaacat gaccaagatg tcttggtgct ggagaaggtc     1440

ccagcaggga acagagcttc taatcaagga aactcacagc ctcagcaaaa gtatactgtg     1500

atgtcaggaa cacctgaaaa aattttagag cattttctag aaacaatacg ccttgaggca     1560

actttaaatg aagcaacaga ttctgtttta aatgacttta ttatgatgca ctgtgttttt     1620

atgccaaata cccagctttg cccggcactg gtggcccact accacgcaca gccttcacaa     1680

ggtacagaac aggagaaaat ggattatgcc ctcaacaata agaggcgagt catccgcctg     1740

gttctacagt gggctgccat gtatggagac ctcctgcaag aggatgacgt gtctatggcc     1800

ttcctggagg agttttatgt atctgtatca gatgatgccc ggatgattgc tgccctcaag     1860

gagcaactgc cagagttgga gaagattgtc aagcaaatct cagaagatgc aaaggcacca     1920

caaaagaagc acaaggttct tttgcaacag ttcaatacgg gcgatgagag agcccagaag     1980

cgccagccta tccgcggctc tgatgaagtt ctgtttaagg tctattgcat ggaccacacc     2040

tacacaacca ttcgggtgcc agtggccact tcggtgaagg aagtcatcag tgcagttgcc     2100

gacaagctgg gctccgggga gggcctgatc atagtcaaga tgagttccgg aggagaaaag     2160

gtggtgctca aacctaatga tgtttcagta tttacgacgc tcaccattaa tggacgcctg     2220

tttgcttgcc cgcgagagca attcgattca ctgactccct taccagaaca ggaaggccca     2280

actgttggaa cagtgggaac ttttgaactg atgagctcca aagatttagc ataccagatg     2340

acaatttatg attgggaact cttcaactgc gtgcatgagc tggagctaat ctatcacaca     2400

tttggaaggc ataattttaa aaagaccaca gcaaacttgg atttgttcct gaggagattt     2460

aatgaaattc agttttgggt cgtcactgag atctgccttt gttctcagct cagcaagcgt     2520

gttcagctat taaaaaaatt tattaagata gcagcccact gtaaggagta taaaaatctg     2580

aattcctttt ttgccatcgt catgggacta agtaacgttg ctgtgagccg cttggcacta     2640

acgtgggaga aactgccaag caagttcaag aagttctatg cggagtttga aagtttaatg     2700

gacccttcaa ggaaccacag ggcctacagg ctgacagtag ctaagctgga acctcctctc     2760

atccccttca tgcctttgct cattaaagat atgacattta ctcatgaggg gaacaagacg     2820

ttcattgaca atctagtaaa ctttgaaaaa atgcgcatga ttgcaaatac ggccagaaca     2880

gtgagatact acaggagcca acccttcaat cctgatgcag ctcaagctaa taagaaccat     2940

caggatgtcc ggagttatgt acggcaatta aatgtgattg acaaccagag aactttatca     3000

cagatgtcac acagattaga gcctcgtcga ccatag                               3036


<210>  416
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Val Ala Ala His Ala Ala His Ser Ser Ser Ser Ala Glu Trp Ile 
1               5                   10                  15      


Ala Cys Leu Asp Lys Arg Pro Leu Glu Arg Ser Ser Glu Asp Val Asp 
            20                  25                  30          


Ile Ile Phe Thr Arg Leu Lys Glu Val Lys Ala Phe Glu Lys Phe His 
        35                  40                  45              


Pro Asn Leu Leu His Gln Ile Cys Leu Cys Gly Tyr Tyr Glu Asn Leu 
    50                  55                  60                  


Glu Lys Gly Ile Thr Leu Phe Arg Gln Gly Asp Ile Gly Thr Asn Trp 
65                  70                  75                  80  


Tyr Ala Val Leu Ala Gly Ser Leu Asp Val Lys Val Ser Glu Thr Ser 
                85                  90                  95      


Ser His Gln Asp Ala Val Thr Ile Cys Thr Leu Gly Ile Gly Thr Ala 
            100                 105                 110         


Phe Gly Glu Ser Ile Leu Asp Asn Thr Pro Arg His Ala Thr Ile Val 
        115                 120                 125             


Thr Arg Glu Ser Ser Glu Leu Leu Arg Ile Glu Gln Lys Asp Phe Lys 
    130                 135                 140                 


Ala Leu Trp Glu Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
145                 150                 155                 160 


Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
                165                 170                 175     


Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
            180                 185                 190         


Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
        195                 200                 205             


Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
    210                 215                 220                 


Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
225                 230                 235                 240 


Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
                245                 250                 255     


Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
            260                 265                 270         


His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
        275                 280                 285             


Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
    290                 295                 300                 


Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
305                 310                 315                 320 


Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
                325                 330                 335     


Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
            340                 345                 350         


His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
        355                 360                 365             


Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
    370                 375                 380                 


Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
385                 390                 395                 400 


Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
                405                 410                 415     


Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
            420                 425                 430         


Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
        435                 440                 445             


Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
    450                 455                 460                 


Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
465                 470                 475                 480 


Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
                485                 490                 495     


Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
            500                 505                 510         


Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
        515                 520                 525             


Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
    530                 535                 540                 


Gln Leu Cys Pro Ala Leu Val Ala His Tyr His Ala Gln Pro Ser Gln 
545                 550                 555                 560 


Gly Thr Glu Gln Glu Lys Met Asp Tyr Ala Leu Asn Asn Lys Arg Arg 
                565                 570                 575     


Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu Leu 
            580                 585                 590         


Gln Glu Asp Asp Val Ser Met Ala Phe Leu Glu Glu Phe Tyr Val Ser 
        595                 600                 605             


Val Ser Asp Asp Ala Arg Met Ile Ala Ala Leu Lys Glu Gln Leu Pro 
    610                 615                 620                 


Glu Leu Glu Lys Ile Val Lys Gln Ile Ser Glu Asp Ala Lys Ala Pro 
625                 630                 635                 640 


Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp Glu 
                645                 650                 655     


Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu Phe 
            660                 665                 670         


Lys Val Tyr Cys Met Asp His Thr Tyr Thr Thr Ile Arg Val Pro Val 
        675                 680                 685             


Ala Thr Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu Gly 
    690                 695                 700                 


Ser Gly Glu Gly Leu Ile Ile Val Lys Met Ser Ser Gly Gly Glu Lys 
705                 710                 715                 720 


Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr Ile 
                725                 730                 735     


Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu Thr 
            740                 745                 750         


Pro Leu Pro Glu Gln Glu Gly Pro Thr Val Gly Thr Val Gly Thr Phe 
        755                 760                 765             


Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Ile Tyr Asp 
    770                 775                 780                 


Trp Glu Leu Phe Asn Cys Val His Glu Leu Glu Leu Ile Tyr His Thr 
785                 790                 795                 800 


Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu Phe 
                805                 810                 815     


Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile Cys 
            820                 825                 830         


Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Phe Ile 
        835                 840                 845             


Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe Phe 
    850                 855                 860                 


Ala Ile Val Met Gly Leu Ser Asn Val Ala Val Ser Arg Leu Ala Leu 
865                 870                 875                 880 


Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu Phe 
                885                 890                 895     


Glu Ser Leu Met Asp Pro Ser Arg Asn His Arg Ala Tyr Arg Leu Thr 
            900                 905                 910         


Val Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu Ile 
        915                 920                 925             


Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp Asn 
    930                 935                 940                 


Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg Thr 
945                 950                 955                 960 


Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln Ala 
                965                 970                 975     


Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn Val 
            980                 985                 990         


Ile Asp Asn Gln Arg Thr Leu Ser  Gln Met Ser His Arg  Leu Glu Pro 
        995                 1000                 1005             


Arg Arg  Pro 
    1010     


<210>  417
<211>  1545
<212>  DNA
<213>  Homo sapiens

<400>  417
atggtgctgg atctggattt gtttcgggtg gataaaggag gggacccagc cctcatccga       60

gagacgcagg agaagcgctt caaggacccg ggactagtgg accagctggt gaaggcagac      120

agcgagtggc gacgatgtag atttcgggca gacaacttga acaagctgaa gaacctatgc      180

agcaagacaa tcggagagaa aatgaagaaa aaagagccag tgggagatga tgagtctgtc      240

ccagagaatg tgctgagttt cgatgacctt actgcagacg ctttagctaa cctgaaagtc      300

tcacaaatca aaaaagtccg actcctcatt gatgaagcca tcctgaagtg tgacgcggag      360

cggataaagt tggaagcaga gcggtttgag aacctccgag agattgggaa ccttctgcac      420

ccttctgtac ccatcagtaa cgatgaggat gtggacaaca aagtagagag gatttggggt      480

gattgtacag tcaggaagaa gtactctcat gtggacctgg tggtgatggt agatggcttt      540

gaaggcgaaa agggggccgt ggtggctggg agtcgagggt acttcttgaa gggggtcctg      600

gtgttcctgg aacaggctct catccagtat gcccttcgca ccttgggaag tcggggctac      660

attcccattt ataccccctt tttcatgagg aaggaggtca tgcaggaggt ggcacagctc      720

agccagtttg atgaagaact ttataaggtg attggcaaag gcagtgaaaa gtctgatgac      780

aactcctatg atgagaagta cctgattgcc acctcagagc agcccattgc tgccctgcac      840

cgggatgagt ggctccggcc ggaggacctg cccatcaagt atgctggcct gtctacctgc      900

ttccgtcagg aggtgggctc ccatggccgt gacacccgtg gcatcttccg agtccatcag      960

tttgagaaga ttgaacagtt tgtgtactca tcaccccatg acaacaagtc atgggagatg     1020

tttgaagaga tgattaccac cgcagaggag ttctaccagt ccctggggat tccttaccac     1080

attgtgaata ttgtctcagg ttctttgaat catgctgcca gtaagaagct tgacctggag     1140

gcctggtttc cgggctcagg agccttccgt gagttggtct cctgttctaa ttgcacggat     1200

taccaggctc gccggcttcg aatccgatat gggcaaacca agaagatgat ggacaaggtg     1260

gagtttgtcc atatgctcaa tgctaccatg tgcgccacta cccgtaccat ctgcgccatc     1320

ctggagaact accagacaga gaagggcatc actgtgcctg agaaattgaa ggagttcatg     1380

ccgccaggac tgcaagaact gatccccttt gtgaagcctg cgcccattga gcaggagcca     1440

tcaaagaagc agaagaagca acatgagggc agcaaaaaga aagcagcagc aagagacgtc     1500

accctagaaa acaggctgca gaacatggag gtcaccgatg cttga                     1545


<210>  418
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro 
1               5                   10                  15      


Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu 
            20                  25                  30          


Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe 
        35                  40                  45              


Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile 
    50                  55                  60                  


Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val 
65                  70                  75                  80  


Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala 
                85                  90                  95      


Asn Leu Lys Val Ser Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu 
            100                 105                 110         


Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg 
        115                 120                 125             


Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro 
    130                 135                 140                 


Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly 
145                 150                 155                 160 


Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met 
                165                 170                 175     


Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg 
            180                 185                 190         


Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile 
        195                 200                 205             


Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr 
    210                 215                 220                 


Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu 
225                 230                 235                 240 


Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu 
                245                 250                 255     


Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser 
            260                 265                 270         


Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu 
        275                 280                 285             


Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu 
    290                 295                 300                 


Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln 
305                 310                 315                 320 


Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys 
                325                 330                 335     


Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr 
            340                 345                 350         


Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser 
        355                 360                 365             


Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro 
    370                 375                 380                 


Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp 
385                 390                 395                 400 


Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met 
                405                 410                 415     


Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala 
            420                 425                 430         


Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys 
        435                 440                 445             


Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu 
    450                 455                 460                 


Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro 
465                 470                 475                 480 


Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala 
                485                 490                 495     


Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr 
            500                 505                 510         


Asp Ala 
        


<210>  419
<211>  6965
<212>  DNA
<213>  Homo sapiens

<400>  419
ggcatggaac ctaaagacta gaggcggttg tgtgagtcag gaagaggggc cagatatctg       60

agtgttcctc tttagtttct tcaattgcag ataatatggt gtctaatttt atgttgttca      120

ggaaagacag tggttcctga ctcaggaaga cagtctcaga aacatgtgga atgatattga      180

gctgctaaca aatgatgata ccggaagtgg gtacctgagt gtcggttcaa gaaaagaaca      240

tggaactgct ttatatcaag tagatttgct agtgaagatc tcttctgaaa aggcctcatt      300

aaatccaaag atacaggcat gcagcttaag tgatgggttt attattgtag ccgaccaatc      360

agtgatattg cttgacagta tttgtagatc acttcaattg catcttgtct ttgatactga      420

agtggatgta gttggccttt gtcaagaagg aaagtttctt ttggttggcg agagaagtgg      480

caacctacat cttattcatg taacatcaaa acaaacacta ctcactaatg catttgttca      540

gaaagctaac gatgaaaatc ggcggactta ccagaatctt gtcattgaga aggatggttc      600

aaatgaaggt acctattata tgctacttct tacatacagt ggattttttt gtattacaaa      660

ccttcagctt ttaaaaattc aacaagcaat tgagaatgta gacttcagta cagcaaaaaa      720

gttacaagga caaatcaagt ccagttttat ttctactgaa aattatcata ctcttggttg      780

tctcagtctt gtggctggag atttagcaag tgaagttcct gtgataattg ggggaaccgg      840

taattgtgca ttctcaaaat gggaaccaga ttcttccaag aaaggaatga cagttaagaa      900

ccttattgat gcagagatta ttaaaggtgc aaagaagttc cagctgatag acaatctact      960

ttttgttctt gatactgata acgtgctgag tttatgggat atttacactc taactcctgt     1020

atggaactgg ccctctcttc acgtagaaga gtttcttctt actacagaag cagactctcc     1080

ttcatcagtc acgtggcaag gaattacaaa tctcaaatta atagctctga cagcttcagc     1140

taataagaag atgaaaaacc tcatggttta ttcattacct acaatggaaa tactatattc     1200

tttggaagta tctagtgttt cttctctggt ccaaacagga attagcacag ataccatata     1260

ccttttagaa ggagtttgca aaaatgatcc aaaattgtct gaagactcag tctctgtgtt     1320

agtactcaga tgtcttacgg aagctttacc agaaaacaga ttgagtcggt tacttcacaa     1380

acacagattt gctgaagctg agagttttgc cattcagttt ggactagatg ttgagcttgt     1440

ttacaaggtc aagtcaaatc atatattgga gaaactggca ttgagttctg tggatgccag     1500

tgaacagacc gaatggcaac aacttgtaga cgacgctaag gaaaatctac ataagatcca     1560

ggatgatgaa tttgtggtga attactgcct gaaagctcag tggataacct atgaaaccac     1620

tcaagagatg ctgaattatg ccaaaaccag gcttttgaag aaagaagata aaactgctct     1680

catttattct gatggcttga aagaggtgct aagagctcat gcaaaattga ctacttttta     1740

tggagcattt ggaccagaaa aattcagtgg cagttcttgg attgaatttc taaataatga     1800

agatgatctt aaagatattt ttttacagct aaaagaagga aaccttgttt gtgcacagta     1860

tctttggctt cgacatcggg caaactttga aagcagattt gatgtgaaaa tgctggagag     1920

cttgctcaac tcaatgtctg catcagtctc tttgcaaaag ctgtgtccat ggtttaaaaa     1980

tgatgtgatt ccatttgtaa gaaggactgt gcctgaagga cagataattc ttgcaaaatg     2040

gttggaacaa gcagccagga accttgaatt aactgataag gcaaattggc cagaaaatgg     2100

acttcaattg gcagagatat tttttacagc agaaaaaaca gacgagttgg gattggcatc     2160

ttcctggcat tggatttcct tgaaagatta tcagaacaca gaggaagtat gtcagctaag     2220

gactttggta aataacttgc gagagttgat cacgttgcat aggaagtaca actgcaaatt     2280

agccctctct gattttgaga aggaaaatac aaccaccata gtgttccgaa tgtttgataa     2340

agtgctggcc ccagagctta ttccctccat cttagagaag tttataagag tttacatgag     2400

agaacatgac ttgcaagagg aggaacttct cttgctgtac atagaggatt tactgaatag     2460

atgcagctca aagtccacat cactctttga aacagcatgg gaagcaaagg ccatggcagt     2520

aatagcgtgt ttatctgaca cggacctcat atttgatgcc gtgctcaaga tcatgtatgc     2580

ggcagtggtt ccttggagtg cagctgtgga gcaactggtg aaacagcacc tggaaatgga     2640

ccatcccaaa gtcaagttat tacaggaaag ttacaaacta atggagatga aaaaactttt     2700

acgaggctat ggaataagag aggtaaatct cttaaacaag gaaataatga gagtggttag     2760

atacattctc aaacaagatg tcccatcttc tttagaagat gctttaaagg tagcccaagc     2820

gtttatgtta tctgatgatg agatctacag tctaagaatt attgacctga ttgatagaga     2880

acagggtgaa gactgtctcc ttctgttgaa gtctttgcct cctgctgaag ctgagaaaac     2940

tgcagaaaga gtcatcatat gggcacgact ggcattacaa gaagagccag atcattctaa     3000

agagggcaag gcctggagaa tgtctgtagc gaagacatcc gtggacattc ttaagatact     3060

atgtgacatt cagaaagaca atctgcagaa gaaggacgaa tgtgaagaaa tgttgaaact     3120

atttaaagag gttgctagct tacaggagaa ctttgaggtc tttctttcat ttgaagatta     3180

tagcaatagt tccctggtag cagatctccg tgagcagcac attaaagctc acgaagttgc     3240

acaggcgaaa cacaaacctg ggagcacccc agagcccata gctgctgagg tgaggagccc     3300

aagcatggaa tcaaagctgc acagacaggc actggccctg cagatgtcca aacaagagct     3360

ggaggcagag ctgaccttga gagccttaaa agatgggaac atcaaaacag cactgaaaaa     3420

atgcagcgac ttgtttaagt atcactgcaa tgctgacact gggaaattgc tatttctgac     3480

atgtcagaag ctttgtcaga tgttggctga taatgtccca gtgacagtgc ctgtgggact     3540

gaatcttcct tccatgatac atgatctagc aagccaagct gccaccattt gcagtccaga     3600

ttttttacta gatgctttag aactatgtaa acatacttta atggctgtag agctttccag     3660

acaatgccaa atggatgact gtggaatcct catgaaagct tcttttggga cacataaaga     3720

tccatatgaa gagtggtctt acagtgactt cttcagtgaa gatggaattg ttcttgagtc     3780

acagatggtg cttccagtga tttatgaact gatttcatct cttgtgcctc tagctgaaag     3840

caagagatat cccttggagt ctaccagttt gccatactgc tcccttaatg aaggagatgg     3900

ccttgtttta cctgttataa attccatctc tgccctgctt cagaatcttc aggaatctag     3960

ccagtgggag ctagccctaa gatttgtggt tggttcattt ggtacctgtc ttcagcactc     4020

tgtgtcaaac ttcatgaatg ccactttgag tgaaaagtta tttggagaga ctacattagt     4080

taaatcaagg catgttgtta tggaattgaa agaaaaagct gttatattta tcagggaaaa     4140

tgctacaaca ctactgcaca aagtatttaa ttgtcgcttg gtagatcttg acctggcgtt     4200

gggttactgc actctcttac ctcaaaaaga tgtgtttgaa aatctctgga agctcataga     4260

taaagcatgg cagaattacg acaaaatctt ggcaatatct ctggtgggct ctgagctggc     4320

aagtctctat caggaaatag aaatggggct taagttccgt gaactcagta ctgatgccca     4380

gtggggcatt cgtcttggta aacttggtat ttcttttcaa ccagttttca ggcaacattt     4440

tctcaccaag aaagacctca ttaaagctct tgtggagaat atagatatgg acacaagcct     4500

cattttggaa tattgcagca catttcagtt ggactgcgat gcagttcttc agctcttcat     4560

tgaaacgctg ctccacaaca caaatgccgg ccaaggccag ggagatgcaa gcatggactc     4620

tgcaaagcgg cggcatccca aactcctggc caaagccctt gagatggttc ctttactgac     4680

gagcacaaaa gatttggtca tcagtcttag tggaatacta cataagttgg atccttatga     4740

ctatgaaatg attgaagttg tcttgaaagt tatagaacga gctgatgaaa agataaccaa     4800

tattaatatt aatcaggcat tgagtattct gaaacatttg aagtcataca gaagaatttc     4860

tcctcccgtg gatctagaat atcagtatat gttggaacat gtcataactt tgccatcagc     4920

tgcccaaact agactgcctt ttcacctgat attctttggc acagcacaga acttctggaa     4980

aattctctct acagaactca gtgaagaatc tttcccaaca ttgctcttaa tttcgaaatt     5040

aatgaagttc tctctggaca ctctgtacgt gtctacagca aaacacgttt tcgaaaaaaa     5100

actgaagcca aagctcctga agttaacaca agctaaatcc tcaacactga ttaacaagga     5160

aataactaag atcacgcaga ccatcgaatc ctgcttactc tctatagtca acccagagtg     5220

ggctgtagct attgccatca gccttgccca ggatatccct gaaggttcct tcaagatatc     5280

tgctttgaaa ttctgccttt atttagctga gagatggcta cagaatatcc catcgcagga     5340

cgaaaaacgt gaaaaagccg aggctttgtt gaagaagctt catatccagt accggcgatc     5400

gggcacagaa gctgtgctca tagcccacaa gctgaacact gaggaatatt taagagtgat     5460

cggaaagcca gcacatctta ttgtcagtct ctacgaacat cctagcatca atcaaagaat     5520

tcagaattca tctggcacag attatcctga tattcatgca gcagctaaag aaatagccga     5580

agtcaatgaa attaatttgg aaaaagtctg ggacatgttg ttggaaaaat ggctatgccc     5640

ttcaacaaaa cctggtgaaa aaccatcaga attatttgaa cttcaagaag atgaagccct     5700

acgaagagtg cagtatctcc tcctgtctcg tccaattgat tatagttcaa gaatgctgtt     5760

tgtatttgca acatcaacta caaccacatt aggtatgcat cagttaactt ttgcccatag     5820

aactcgagct cttcagtgtc tcttctattt ggctgacaag gaaactatag aatctctctt     5880

taaaaaaccc attgaagaag tgaaatctta tttgagatgt ataacttttc tggcatcatt     5940

tgagactttg aatatcccca tcacatatga attattttgc agcagtccta aagaaggaat     6000

gattaagggt ctgtggaaaa accacagcca cgagtccatg gcagtaagat tggtgactga     6060

gctgtgttta gaatacaaaa tctatgacct gcagctttgg aatggactct tgcaaaagct     6120

tctgggcttc aatatgattc cttatctaag gaaagtttta aaagccatct ccagtatcca     6180

ttctttatgg caggttccct acttcagcaa agcgtggcag cgtgtgatac agataccact     6240

gctttcagcc tcttgtcctt taagtcctga tcagctgtca gattgttctg agagtctcat     6300

cgctgtcctc gaatgtccag tctcaggtga tcttgacctg atcggagtcg ccaggcagta     6360

tatccagtta gaacttccgg cttttgcatt agcttgtctg atgctcatgc cccactcaga     6420

gaaaagacac cagcaaatta agaattttct gggttcctgt gaccctcagg ttattttaaa     6480

gcaattggaa gagcatatga acacgggcca gctagcagga ttttcacatc aaattagaag     6540

tctgattttg aataatatca tcaataagaa ggagtttggg attttggcaa agaccaaata     6600

ctttcaaatg ttgaagatgc atgcgatgaa taccaacaat atcactgagc tagtgaacta     6660

tttggcaaat gacttaagtt tagatgaagc ttcagtcttg ataactgaat attcaaagca     6720

ctgcgggaaa cctgtgcctc cagacactgc tccctgtgaa attctgaaga tgtttcttag     6780

tggattatcg taaatcactg aacctttttt tcaagaagga caagaatttt ggagtctgct     6840

attaatggac catatttatt acagttttta aattgtacaa tctctgtatt atagctattt     6900

gtctaacatt accccacatg taataaataa aacaatatga gcataattgc cccataaaga     6960

actca                                                                 6965


<210>  420
<211>  2209
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Trp Asn Asp Ile Glu Leu Leu Thr Asn Asp Asp Thr Gly Ser Gly 
1               5                   10                  15      


Tyr Leu Ser Val Gly Ser Arg Lys Glu His Gly Thr Ala Leu Tyr Gln 
            20                  25                  30          


Val Asp Leu Leu Val Lys Ile Ser Ser Glu Lys Ala Ser Leu Asn Pro 
        35                  40                  45              


Lys Ile Gln Ala Cys Ser Leu Ser Asp Gly Phe Ile Ile Val Ala Asp 
    50                  55                  60                  


Gln Ser Val Ile Leu Leu Asp Ser Ile Cys Arg Ser Leu Gln Leu His 
65                  70                  75                  80  


Leu Val Phe Asp Thr Glu Val Asp Val Val Gly Leu Cys Gln Glu Gly 
                85                  90                  95      


Lys Phe Leu Leu Val Gly Glu Arg Ser Gly Asn Leu His Leu Ile His 
            100                 105                 110         


Val Thr Ser Lys Gln Thr Leu Leu Thr Asn Ala Phe Val Gln Lys Ala 
        115                 120                 125             


Asn Asp Glu Asn Arg Arg Thr Tyr Gln Asn Leu Val Ile Glu Lys Asp 
    130                 135                 140                 


Gly Ser Asn Glu Gly Thr Tyr Tyr Met Leu Leu Leu Thr Tyr Ser Gly 
145                 150                 155                 160 


Phe Phe Cys Ile Thr Asn Leu Gln Leu Leu Lys Ile Gln Gln Ala Ile 
                165                 170                 175     


Glu Asn Val Asp Phe Ser Thr Ala Lys Lys Leu Gln Gly Gln Ile Lys 
            180                 185                 190         


Ser Ser Phe Ile Ser Thr Glu Asn Tyr His Thr Leu Gly Cys Leu Ser 
        195                 200                 205             


Leu Val Ala Gly Asp Leu Ala Ser Glu Val Pro Val Ile Ile Gly Gly 
    210                 215                 220                 


Thr Gly Asn Cys Ala Phe Ser Lys Trp Glu Pro Asp Ser Ser Lys Lys 
225                 230                 235                 240 


Gly Met Thr Val Lys Asn Leu Ile Asp Ala Glu Ile Ile Lys Gly Ala 
                245                 250                 255     


Lys Lys Phe Gln Leu Ile Asp Asn Leu Leu Phe Val Leu Asp Thr Asp 
            260                 265                 270         


Asn Val Leu Ser Leu Trp Asp Ile Tyr Thr Leu Thr Pro Val Trp Asn 
        275                 280                 285             


Trp Pro Ser Leu His Val Glu Glu Phe Leu Leu Thr Thr Glu Ala Asp 
    290                 295                 300                 


Ser Pro Ser Ser Val Thr Trp Gln Gly Ile Thr Asn Leu Lys Leu Ile 
305                 310                 315                 320 


Ala Leu Thr Ala Ser Ala Asn Lys Lys Met Lys Asn Leu Met Val Tyr 
                325                 330                 335     


Ser Leu Pro Thr Met Glu Ile Leu Tyr Ser Leu Glu Val Ser Ser Val 
            340                 345                 350         


Ser Ser Leu Val Gln Thr Gly Ile Ser Thr Asp Thr Ile Tyr Leu Leu 
        355                 360                 365             


Glu Gly Val Cys Lys Asn Asp Pro Lys Leu Ser Glu Asp Ser Val Ser 
    370                 375                 380                 


Val Leu Val Leu Arg Cys Leu Thr Glu Ala Leu Pro Glu Asn Arg Leu 
385                 390                 395                 400 


Ser Arg Leu Leu His Lys His Arg Phe Ala Glu Ala Glu Ser Phe Ala 
                405                 410                 415     


Ile Gln Phe Gly Leu Asp Val Glu Leu Val Tyr Lys Val Lys Ser Asn 
            420                 425                 430         


His Ile Leu Glu Lys Leu Ala Leu Ser Ser Val Asp Ala Ser Glu Gln 
        435                 440                 445             


Thr Glu Trp Gln Gln Leu Val Asp Asp Ala Lys Glu Asn Leu His Lys 
    450                 455                 460                 


Ile Gln Asp Asp Glu Phe Val Val Asn Tyr Cys Leu Lys Ala Gln Trp 
465                 470                 475                 480 


Ile Thr Tyr Glu Thr Thr Gln Glu Met Leu Asn Tyr Ala Lys Thr Arg 
                485                 490                 495     


Leu Leu Lys Lys Glu Asp Lys Thr Ala Leu Ile Tyr Ser Asp Gly Leu 
            500                 505                 510         


Lys Glu Val Leu Arg Ala His Ala Lys Leu Thr Thr Phe Tyr Gly Ala 
        515                 520                 525             


Phe Gly Pro Glu Lys Phe Ser Gly Ser Ser Trp Ile Glu Phe Leu Asn 
    530                 535                 540                 


Asn Glu Asp Asp Leu Lys Asp Ile Phe Leu Gln Leu Lys Glu Gly Asn 
545                 550                 555                 560 


Leu Val Cys Ala Gln Tyr Leu Trp Leu Arg His Arg Ala Asn Phe Glu 
                565                 570                 575     


Ser Arg Phe Asp Val Lys Met Leu Glu Ser Leu Leu Asn Ser Met Ser 
            580                 585                 590         


Ala Ser Val Ser Leu Gln Lys Leu Cys Pro Trp Phe Lys Asn Asp Val 
        595                 600                 605             


Ile Pro Phe Val Arg Arg Thr Val Pro Glu Gly Gln Ile Ile Leu Ala 
    610                 615                 620                 


Lys Trp Leu Glu Gln Ala Ala Arg Asn Leu Glu Leu Thr Asp Lys Ala 
625                 630                 635                 640 


Asn Trp Pro Glu Asn Gly Leu Gln Leu Ala Glu Ile Phe Phe Thr Ala 
                645                 650                 655     


Glu Lys Thr Asp Glu Leu Gly Leu Ala Ser Ser Trp His Trp Ile Ser 
            660                 665                 670         


Leu Lys Asp Tyr Gln Asn Thr Glu Glu Val Cys Gln Leu Arg Thr Leu 
        675                 680                 685             


Val Asn Asn Leu Arg Glu Leu Ile Thr Leu His Arg Lys Tyr Asn Cys 
    690                 695                 700                 


Lys Leu Ala Leu Ser Asp Phe Glu Lys Glu Asn Thr Thr Thr Ile Val 
705                 710                 715                 720 


Phe Arg Met Phe Asp Lys Val Leu Ala Pro Glu Leu Ile Pro Ser Ile 
                725                 730                 735     


Leu Glu Lys Phe Ile Arg Val Tyr Met Arg Glu His Asp Leu Gln Glu 
            740                 745                 750         


Glu Glu Leu Leu Leu Leu Tyr Ile Glu Asp Leu Leu Asn Arg Cys Ser 
        755                 760                 765             


Ser Lys Ser Thr Ser Leu Phe Glu Thr Ala Trp Glu Ala Lys Ala Met 
    770                 775                 780                 


Ala Val Ile Ala Cys Leu Ser Asp Thr Asp Leu Ile Phe Asp Ala Val 
785                 790                 795                 800 


Leu Lys Ile Met Tyr Ala Ala Val Val Pro Trp Ser Ala Ala Val Glu 
                805                 810                 815     


Gln Leu Val Lys Gln His Leu Glu Met Asp His Pro Lys Val Lys Leu 
            820                 825                 830         


Leu Gln Glu Ser Tyr Lys Leu Met Glu Met Lys Lys Leu Leu Arg Gly 
        835                 840                 845             


Tyr Gly Ile Arg Glu Val Asn Leu Leu Asn Lys Glu Ile Met Arg Val 
    850                 855                 860                 


Val Arg Tyr Ile Leu Lys Gln Asp Val Pro Ser Ser Leu Glu Asp Ala 
865                 870                 875                 880 


Leu Lys Val Ala Gln Ala Phe Met Leu Ser Asp Asp Glu Ile Tyr Ser 
                885                 890                 895     


Leu Arg Ile Ile Asp Leu Ile Asp Arg Glu Gln Gly Glu Asp Cys Leu 
            900                 905                 910         


Leu Leu Leu Lys Ser Leu Pro Pro Ala Glu Ala Glu Lys Thr Ala Glu 
        915                 920                 925             


Arg Val Ile Ile Trp Ala Arg Leu Ala Leu Gln Glu Glu Pro Asp His 
    930                 935                 940                 


Ser Lys Glu Gly Lys Ala Trp Arg Met Ser Val Ala Lys Thr Ser Val 
945                 950                 955                 960 


Asp Ile Leu Lys Ile Leu Cys Asp Ile Gln Lys Asp Asn Leu Gln Lys 
                965                 970                 975     


Lys Asp Glu Cys Glu Glu Met Leu Lys Leu Phe Lys Glu Val Ala Ser 
            980                 985                 990         


Leu Gln Glu Asn Phe Glu Val Phe  Leu Ser Phe Glu Asp  Tyr Ser Asn 
        995                 1000                 1005             


Ser Ser  Leu Val Ala Asp Leu  Arg Glu Gln His Ile  Lys Ala His 
    1010                 1015                 1020             


Glu Val  Ala Gln Ala Lys His  Lys Pro Gly Ser Thr  Pro Glu Pro 
    1025                 1030                 1035             


Ile Ala  Ala Glu Val Arg Ser  Pro Ser Met Glu Ser  Lys Leu His 
    1040                 1045                 1050             


Arg Gln  Ala Leu Ala Leu Gln  Met Ser Lys Gln Glu  Leu Glu Ala 
    1055                 1060                 1065             


Glu Leu  Thr Leu Arg Ala Leu  Lys Asp Gly Asn Ile  Lys Thr Ala 
    1070                 1075                 1080             


Leu Lys  Lys Cys Ser Asp Leu  Phe Lys Tyr His Cys  Asn Ala Asp 
    1085                 1090                 1095             


Thr Gly  Lys Leu Leu Phe Leu  Thr Cys Gln Lys Leu  Cys Gln Met 
    1100                 1105                 1110             


Leu Ala  Asp Asn Val Pro Val  Thr Val Pro Val Gly  Leu Asn Leu 
    1115                 1120                 1125             


Pro Ser  Met Ile His Asp Leu  Ala Ser Gln Ala Ala  Thr Ile Cys 
    1130                 1135                 1140             


Ser Pro  Asp Phe Leu Leu Asp  Ala Leu Glu Leu Cys  Lys His Thr 
    1145                 1150                 1155             


Leu Met  Ala Val Glu Leu Ser  Arg Gln Cys Gln Met  Asp Asp Cys 
    1160                 1165                 1170             


Gly Ile  Leu Met Lys Ala Ser  Phe Gly Thr His Lys  Asp Pro Tyr 
    1175                 1180                 1185             


Glu Glu  Trp Ser Tyr Ser Asp  Phe Phe Ser Glu Asp  Gly Ile Val 
    1190                 1195                 1200             


Leu Glu  Ser Gln Met Val Leu  Pro Val Ile Tyr Glu  Leu Ile Ser 
    1205                 1210                 1215             


Ser Leu  Val Pro Leu Ala Glu  Ser Lys Arg Tyr Pro  Leu Glu Ser 
    1220                 1225                 1230             


Thr Ser  Leu Pro Tyr Cys Ser  Leu Asn Glu Gly Asp  Gly Leu Val 
    1235                 1240                 1245             


Leu Pro  Val Ile Asn Ser Ile  Ser Ala Leu Leu Gln  Asn Leu Gln 
    1250                 1255                 1260             


Glu Ser  Ser Gln Trp Glu Leu  Ala Leu Arg Phe Val  Val Gly Ser 
    1265                 1270                 1275             


Phe Gly  Thr Cys Leu Gln His  Ser Val Ser Asn Phe  Met Asn Ala 
    1280                 1285                 1290             


Thr Leu  Ser Glu Lys Leu Phe  Gly Glu Thr Thr Leu  Val Lys Ser 
    1295                 1300                 1305             


Arg His  Val Val Met Glu Leu  Lys Glu Lys Ala Val  Ile Phe Ile 
    1310                 1315                 1320             


Arg Glu  Asn Ala Thr Thr Leu  Leu His Lys Val Phe  Asn Cys Arg 
    1325                 1330                 1335             


Leu Val  Asp Leu Asp Leu Ala  Leu Gly Tyr Cys Thr  Leu Leu Pro 
    1340                 1345                 1350             


Gln Lys  Asp Val Phe Glu Asn  Leu Trp Lys Leu Ile  Asp Lys Ala 
    1355                 1360                 1365             


Trp Gln  Asn Tyr Asp Lys Ile  Leu Ala Ile Ser Leu  Val Gly Ser 
    1370                 1375                 1380             


Glu Leu  Ala Ser Leu Tyr Gln  Glu Ile Glu Met Gly  Leu Lys Phe 
    1385                 1390                 1395             


Arg Glu  Leu Ser Thr Asp Ala  Gln Trp Gly Ile Arg  Leu Gly Lys 
    1400                 1405                 1410             


Leu Gly  Ile Ser Phe Gln Pro  Val Phe Arg Gln His  Phe Leu Thr 
    1415                 1420                 1425             


Lys Lys  Asp Leu Ile Lys Ala  Leu Val Glu Asn Ile  Asp Met Asp 
    1430                 1435                 1440             


Thr Ser  Leu Ile Leu Glu Tyr  Cys Ser Thr Phe Gln  Leu Asp Cys 
    1445                 1450                 1455             


Asp Ala  Val Leu Gln Leu Phe  Ile Glu Thr Leu Leu  His Asn Thr 
    1460                 1465                 1470             


Asn Ala  Gly Gln Gly Gln Gly  Asp Ala Ser Met Asp  Ser Ala Lys 
    1475                 1480                 1485             


Arg Arg  His Pro Lys Leu Leu  Ala Lys Ala Leu Glu  Met Val Pro 
    1490                 1495                 1500             


Leu Leu  Thr Ser Thr Lys Asp  Leu Val Ile Ser Leu  Ser Gly Ile 
    1505                 1510                 1515             


Leu His  Lys Leu Asp Pro Tyr  Asp Tyr Glu Met Ile  Glu Val Val 
    1520                 1525                 1530             


Leu Lys  Val Ile Glu Arg Ala  Asp Glu Lys Ile Thr  Asn Ile Asn 
    1535                 1540                 1545             


Ile Asn  Gln Ala Leu Ser Ile  Leu Lys His Leu Lys  Ser Tyr Arg 
    1550                 1555                 1560             


Arg Ile  Ser Pro Pro Val Asp  Leu Glu Tyr Gln Tyr  Met Leu Glu 
    1565                 1570                 1575             


His Val  Ile Thr Leu Pro Ser  Ala Ala Gln Thr Arg  Leu Pro Phe 
    1580                 1585                 1590             


His Leu  Ile Phe Phe Gly Thr  Ala Gln Asn Phe Trp  Lys Ile Leu 
    1595                 1600                 1605             


Ser Thr  Glu Leu Ser Glu Glu  Ser Phe Pro Thr Leu  Leu Leu Ile 
    1610                 1615                 1620             


Ser Lys  Leu Met Lys Phe Ser  Leu Asp Thr Leu Tyr  Val Ser Thr 
    1625                 1630                 1635             


Ala Lys  His Val Phe Glu Lys  Lys Leu Lys Pro Lys  Leu Leu Lys 
    1640                 1645                 1650             


Leu Thr  Gln Ala Lys Ser Ser  Thr Leu Ile Asn Lys  Glu Ile Thr 
    1655                 1660                 1665             


Lys Ile  Thr Gln Thr Ile Glu  Ser Cys Leu Leu Ser  Ile Val Asn 
    1670                 1675                 1680             


Pro Glu  Trp Ala Val Ala Ile  Ala Ile Ser Leu Ala  Gln Asp Ile 
    1685                 1690                 1695             


Pro Glu  Gly Ser Phe Lys Ile  Ser Ala Leu Lys Phe  Cys Leu Tyr 
    1700                 1705                 1710             


Leu Ala  Glu Arg Trp Leu Gln  Asn Ile Pro Ser Gln  Asp Glu Lys 
    1715                 1720                 1725             


Arg Glu  Lys Ala Glu Ala Leu  Leu Lys Lys Leu His  Ile Gln Tyr 
    1730                 1735                 1740             


Arg Arg  Ser Gly Thr Glu Ala  Val Leu Ile Ala His  Lys Leu Asn 
    1745                 1750                 1755             


Thr Glu  Glu Tyr Leu Arg Val  Ile Gly Lys Pro Ala  His Leu Ile 
    1760                 1765                 1770             


Val Ser  Leu Tyr Glu His Pro  Ser Ile Asn Gln Arg  Ile Gln Asn 
    1775                 1780                 1785             


Ser Ser  Gly Thr Asp Tyr Pro  Asp Ile His Ala Ala  Ala Lys Glu 
    1790                 1795                 1800             


Ile Ala  Glu Val Asn Glu Ile  Asn Leu Glu Lys Val  Trp Asp Met 
    1805                 1810                 1815             


Leu Leu  Glu Lys Trp Leu Cys  Pro Ser Thr Lys Pro  Gly Glu Lys 
    1820                 1825                 1830             


Pro Ser  Glu Leu Phe Glu Leu  Gln Glu Asp Glu Ala  Leu Arg Arg 
    1835                 1840                 1845             


Val Gln  Tyr Leu Leu Leu Ser  Arg Pro Ile Asp Tyr  Ser Ser Arg 
    1850                 1855                 1860             


Met Leu  Phe Val Phe Ala Thr  Ser Thr Thr Thr Thr  Leu Gly Met 
    1865                 1870                 1875             


His Gln  Leu Thr Phe Ala His  Arg Thr Arg Ala Leu  Gln Cys Leu 
    1880                 1885                 1890             


Phe Tyr  Leu Ala Asp Lys Glu  Thr Ile Glu Ser Leu  Phe Lys Lys 
    1895                 1900                 1905             


Pro Ile  Glu Glu Val Lys Ser  Tyr Leu Arg Cys Ile  Thr Phe Leu 
    1910                 1915                 1920             


Ala Ser  Phe Glu Thr Leu Asn  Ile Pro Ile Thr Tyr  Glu Leu Phe 
    1925                 1930                 1935             


Cys Ser  Ser Pro Lys Glu Gly  Met Ile Lys Gly Leu  Trp Lys Asn 
    1940                 1945                 1950             


His Ser  His Glu Ser Met Ala  Val Arg Leu Val Thr  Glu Leu Cys 
    1955                 1960                 1965             


Leu Glu  Tyr Lys Ile Tyr Asp  Leu Gln Leu Trp Asn  Gly Leu Leu 
    1970                 1975                 1980             


Gln Lys  Leu Leu Gly Phe Asn  Met Ile Pro Tyr Leu  Arg Lys Val 
    1985                 1990                 1995             


Leu Lys  Ala Ile Ser Ser Ile  His Ser Leu Trp Gln  Val Pro Tyr 
    2000                 2005                 2010             


Phe Ser  Lys Ala Trp Gln Arg  Val Ile Gln Ile Pro  Leu Leu Ser 
    2015                 2020                 2025             


Ala Ser  Cys Pro Leu Ser Pro  Asp Gln Leu Ser Asp  Cys Ser Glu 
    2030                 2035                 2040             


Ser Leu  Ile Ala Val Leu Glu  Cys Pro Val Ser Gly  Asp Leu Asp 
    2045                 2050                 2055             


Leu Ile  Gly Val Ala Arg Gln  Tyr Ile Gln Leu Glu  Leu Pro Ala 
    2060                 2065                 2070             


Phe Ala  Leu Ala Cys Leu Met  Leu Met Pro His Ser  Glu Lys Arg 
    2075                 2080                 2085             


His Gln  Gln Ile Lys Asn Phe  Leu Gly Ser Cys Asp  Pro Gln Val 
    2090                 2095                 2100             


Ile Leu  Lys Gln Leu Glu Glu  His Met Asn Thr Gly  Gln Leu Ala 
    2105                 2110                 2115             


Gly Phe  Ser His Gln Ile Arg  Ser Leu Ile Leu Asn  Asn Ile Ile 
    2120                 2125                 2130             


Asn Lys  Lys Glu Phe Gly Ile  Leu Ala Lys Thr Lys  Tyr Phe Gln 
    2135                 2140                 2145             


Met Leu  Lys Met His Ala Met  Asn Thr Asn Asn Ile  Thr Glu Leu 
    2150                 2155                 2160             


Val Asn  Tyr Leu Ala Asn Asp  Leu Ser Leu Asp Glu  Ala Ser Val 
    2165                 2170                 2175             


Leu Ile  Thr Glu Tyr Ser Lys  His Cys Gly Lys Pro  Val Pro Pro 
    2180                 2185                 2190             


Asp Thr  Ala Pro Cys Glu Ile  Leu Lys Met Phe Leu  Ser Gly Leu 
    2195                 2200                 2205             


Ser 
    


<210>  421
<211>  4101
<212>  DNA
<213>  Homo sapiens

<400>  421
atgctcagct ttgtggatac gcggactttg ttgctgcttg cagtaacctt atgcctagca       60

acatgccaat ctttacaaga ggaaactgta agaaagggcc cagccggaga tagaggacca      120

cgtggagaaa ggggtccacc aggcccccca ggcagagatg gtgaagatgg tcccacaggc      180

cctcctggtc cacctggtcc tcctggcccc cctggtctcg gtgggaactt tgctgctcag      240

tatgatggaa aaggagttgg acttggccct ggaccaatgg gcttaatggg acctagaggc      300

ccacctggtg cagctggagc cccaggccct caaggtttcc aaggacctgc tggtgagcct      360

ggtgaacctg gtcaaactgg tcctgcaggt gctcgtggtc cagctggccc tcctggcaag      420

gctggtgaag atggtcaccc tggaaaaccc ggacgacctg gtgagagagg agttgttgga      480

ccacagggtg ctcgtggttt ccctggaact cctggacttc ctggcttcaa aggcattagg      540

ggacacaatg gtctggatgg attgaaggga cagcccggtg ctcctggtgt gaagggtgaa      600

cctggtgccc ctggtgaaaa tggaactcca ggtcaaacag gagcccgtgg gcttcctggt      660

gagagaggac gtgttggtgc ccctggccca gctggtgccc gtggcagtga tggaagtgtg      720

ggtcccgtgg gtcctgctgg tcccattggg tctgctggcc ctccaggctt cccaggtgcc      780

cctggcccca agggtgaaat tggagctgtt ggtaacgctg gtcctgctgg tcccgccggt      840

ccccgtggtg aagtgggtct tccaggcctc tccggccccg ttggacctcc tggtaatcct      900

ggagcaaacg gccttactgg tgccaagggt gctgctggcc ttcccggcgt tgctggggct      960

cccggcctcc ctggaccccg cggtattcct ggccctgttg gtgctgccgg tgctactggt     1020

gccagaggac ttgttggtga gcctggtcca gctggctcca aaggagagag cggtaacaag     1080

ggtgagcccg gctctgctgg gccccaaggt cctcctggtc ccagtggtga agaaggaaag     1140

agaggcccta atggggaagc tggatctgcc ggccctccag gacctcctgg gctgagaggt     1200

agtcctggtt ctcgtggtct tcctggagct gatggcagag ctggcgtcat gggccctcct     1260

ggtagtcgtg gtgcaagtgg ccctgctgga gtccgaggac ctaatggaga tgctggtcgc     1320

cctggggagc ctggtctcat gggacccaga ggtcttcctg gttcccctgg aaatatcggc     1380

cccgctggaa aagaaggtcc tgtcggcctc cctggcatcg acggcaggcc tggcccaatt     1440

ggcccagctg gagcaagagg agagcctggc aacattggat tccctggacc caaaggcccc     1500

actggtgatc ctggcaaaaa cggtgataaa ggtcatgctg gtcttgctgg tgctcggggt     1560

gctccaggtc ctgatggaaa caatggtgct cagggacctc ctggaccaca gggtgttcaa     1620

ggtggaaaag gtgaacaggg tccccctggt cctccaggct tccagggtct gcctggcccc     1680

tcaggtcccg ctggtgaagt tggcaaacca ggagaaaggg gtctccatgg tgagtttggt     1740

ctccctggtc ctgctggtcc aagaggggaa cgcggtcccc caggtgagag tggtgctgcc     1800

ggtcctactg gtcctattgg aagccgaggt ccttctggac ccccagggcc tgatggaaac     1860

aagggtgaac ctggtgtggt tggtgctgtg ggcactgctg gtccatctgg tcctagtgga     1920

ctcccaggag agaggggtgc tgctggcata cctggaggca agggagaaaa gggtgaacct     1980

ggtctcagag gtgaaattgg taaccctggc agagatggtg ctcgtggtgc tcctggtgct     2040

gtaggtgccc ctggtcctgc tggagccaca ggtgaccggg gcgaagctgg ggctgctggt     2100

cctgctggtc ctgctggtcc tcggggaagc cctggtgaac gtggtgaggt cggtcctgct     2160

ggccccaatg gatttgctgg tcctgctggt gctgctggtc aacctggtgc taaaggagaa     2220

agaggagcca aagggcctaa gggtgaaaac ggtgttgttg gtcccacagg ccccgttgga     2280

gctgctggcc cagctggtcc aaatggtccc cccggtcctg ctggaagtcg tggtgatgga     2340

ggcccccctg gtatgactgg tttccctggt gctgctggac ggactggtcc cccaggaccc     2400

tctggtattt ctggccctcc tggtccccct ggtcctgctg ggaaagaagg gcttcgtggt     2460

cctcgtggtg accaaggtcc agttggccga actggagaag taggtgcagt tggtccccct     2520

ggcttcgctg gtgagaaggg tccctctgga gaggctggta ctgctggacc tcctggcact     2580

ccaggtcctc agggtcttct tggtgctcct ggtattctgg gtctccctgg ctcgagaggt     2640

gaacgtggtc taccaggtgt tgctggtgct gtgggtgaac ctggtcctct tggcattgcc     2700

ggccctcctg gggcccgtgg tcctcctggt gctgtgggta gtcctggagt caacggtgct     2760

cctggtgaag ctggtcgtga tggcaaccct gggaacgatg gtcccccagg tcgcgatggt     2820

caacccggac acaagggaga gcgcggttac cctggcaata ttggtcccgt tggtgctgca     2880

ggtgcacctg gtcctcatgg ccccgtgggt cctgctggca aacatggaaa ccgtggtgaa     2940

actggtcctt ctggtcctgt tggtcctgct ggtgctgttg gcccaagagg tcctagtggc     3000

ccacaaggca ttcgtggcga taagggagag cccggtgaaa aggggcccag aggtcttcct     3060

ggcttaaagg gacacaatgg attgcaaggt ctgcctggta tcgctggtca ccatggtgat     3120

caaggtgctc ctggctccgt gggtcctgct ggtcctaggg gccctgctgg tccttctggc     3180

cctgctggaa aagatggtcg cactggacat cctggtacag ttggacctgc tggcattcga     3240

ggccctcagg gtcaccaagg ccctgctggc ccccctggtc cccctggccc tcctggacct     3300

ccaggtgtaa gcggtggtgg ttatgacttt ggttacgatg gagacttcta cagggctgac     3360

cagcctcgct cagcaccttc tctcagaccc aaggactatg aagttgatgc tactctgaag     3420

tctctcaaca accagattga gacccttctt actcctgaag gctctagaaa gaacccagct     3480

cgcacatgcc gtgacttgag actcagccac ccagagtgga gcagtggtta ctactggatt     3540

gaccctaacc aaggatgcac tatggatgct atcaaagtat actgtgattt ctctactggc     3600

gaaacctgta tccgggccca acctgaaaac atcccagcca agaactggta taggagctcc     3660

aaggacaaga aacacgtctg gctaggagaa actatcaatg ctggcagcca gtttgaatat     3720

aatgtagaag gagtgacttc caaggaaatg gctacccaac ttgccttcat gcgcctgctg     3780

gccaactatg cctctcagaa catcacctac cactgcaaga acagcattgc atacatggat     3840

gaggagactg gcaacctgaa aaaggctgtc attctacagg gctctaatga tgttgaactt     3900

gttgctgagg gcaacagcag gttcacttac actgttcttg tagatggctg ctctaaaaag     3960

acaaatgaat ggggaaagac aatcattgaa tacaaaacaa ataagccatc acgcctgccc     4020

ttccttgata ttgcaccttt ggacatcggt ggtgctgacc aggaattctt tgtggacatt     4080

ggcccagtct gtttcaaata a                                               4101


<210>  422
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  423
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  423
atgttgacag tcgctctcct agcccttctc tgtgcctcag cctctggcaa tgccattcag       60

gccaggtctt cctcctatag tggagagtat ggaagtggtg gtggaaagcg attctctcat      120

tctggcaacc agttggacgg ccccatcacc gccctccggg tccgagtcaa cacatactac      180

atcgtaggtc ttcaggtgcg ctatggcaag gtgtggagcg actatgtggg tggtcgcaac      240

ggagacctgg aggagatctt tctgcaccct ggggaatcag tgatccaggt ttctgggaag      300

tacaagtggt acctgaagaa gctggtattt gtgacagaca agggccgcta tctgtctttt      360

gggaaagaca gtggcacaag tttcaatgcc gtccccttgc accccaacac cgtgctccgc      420

ttcatcagtg gccggtctgg ttctctcatc gatgccattg gcctgcactg ggatgtttac      480

cccactagct gcagcagatg ctga                                             504


<210>  424
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Leu Thr Val Ala Leu Leu Ala Leu Leu Cys Ala Ser Ala Ser Gly 
1               5                   10                  15      


Asn Ala Ile Gln Ala Arg Ser Ser Ser Tyr Ser Gly Glu Tyr Gly Ser 
            20                  25                  30          


Gly Gly Gly Lys Arg Phe Ser His Ser Gly Asn Gln Leu Asp Gly Pro 
        35                  40                  45              


Ile Thr Ala Leu Arg Val Arg Val Asn Thr Tyr Tyr Ile Val Gly Leu 
    50                  55                  60                  


Gln Val Arg Tyr Gly Lys Val Trp Ser Asp Tyr Val Gly Gly Arg Asn 
65                  70                  75                  80  


Gly Asp Leu Glu Glu Ile Phe Leu His Pro Gly Glu Ser Val Ile Gln 
                85                  90                  95      


Val Ser Gly Lys Tyr Lys Trp Tyr Leu Lys Lys Leu Val Phe Val Thr 
            100                 105                 110         


Asp Lys Gly Arg Tyr Leu Ser Phe Gly Lys Asp Ser Gly Thr Ser Phe 
        115                 120                 125             


Asn Ala Val Pro Leu His Pro Asn Thr Val Leu Arg Phe Ile Ser Gly 
    130                 135                 140                 


Arg Ser Gly Ser Leu Ile Asp Ala Ile Gly Leu His Trp Asp Val Tyr 
145                 150                 155                 160 


Pro Thr Ser Cys Ser Arg Cys 
                165         


<210>  425
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  425
atggcgcagt acaagggcac catgcgcgag gcaggccgtg ccatgcacct cctcaagaag       60

cgcgaaaggc agcgggagca gatggaggtg ctgaagcagc gcatcgccga ggagaccatc      120

ctcaagtcgc aggtggacaa gaggttctcg gcgcattacg acgccgtgga ggccgagctg      180

aagtccagca cggtgggcct ggtgaccctg aacgacatga aggcccggca ggaggccctg      240

gtcagggagc gcgagcggca gctggccaag cgccagcacc tggaggagca gcggctgcag      300

caggagcggc agcgggagca ggagcagcgg cgcgagcgca agcgtaagat ctcctgcctg      360

tcctttgcac tagacgacct cgatgaccag gccgacgcgg ccgaggccag gcgcgccgga      420

aacctgggca agaaccccga cgtggacacc agcttcctgc cagaccgcga ccgcgaggag      480

gaggagaacc ggctccgaga ggagctgcgc caagagtggg aggcgcagcg cgagaaagtg      540

aaggacgagg agatggaggt caccttcagc tactgggacg gctcgggcca ccggcgcacg      600

gtgcgggtgc gcaagggcaa cacggtgcag cagttcctga agaaggcgct gcaggggctg      660

cgcaaggact tcctggagct gcgctccgcc ggcgtggagc agctcatgtt catcaaggag      720

gacctcatcc tgccgcacta ccacaccttc tacgacttca tcatcgccag ggcgaggggc      780

aagagcgggc cgctcttcag cttcgatgtg cacgatgacg tgcgcctgct cagcgacgcc      840

accatggaga aggacgagtc gcacgcgggc aaggtggtgc tgcgcagctg gtacgagaag      900

aacaagcaca tcttccccgc cagccgctgg gaggcctatg accccgagaa gaagtgggac      960

aagtacacca tccgctaa                                                    978


<210>  426
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Ala Gln Tyr Lys Gly Thr Met Arg Glu Ala Gly Arg Ala Met His 
1               5                   10                  15      


Leu Leu Lys Lys Arg Glu Arg Gln Arg Glu Gln Met Glu Val Leu Lys 
            20                  25                  30          


Gln Arg Ile Ala Glu Glu Thr Ile Leu Lys Ser Gln Val Asp Lys Arg 
        35                  40                  45              


Phe Ser Ala His Tyr Asp Ala Val Glu Ala Glu Leu Lys Ser Ser Thr 
    50                  55                  60                  


Val Gly Leu Val Thr Leu Asn Asp Met Lys Ala Arg Gln Glu Ala Leu 
65                  70                  75                  80  


Val Arg Glu Arg Glu Arg Gln Leu Ala Lys Arg Gln His Leu Glu Glu 
                85                  90                  95      


Gln Arg Leu Gln Gln Glu Arg Gln Arg Glu Gln Glu Gln Arg Arg Glu 
            100                 105                 110         


Arg Lys Arg Lys Ile Ser Cys Leu Ser Phe Ala Leu Asp Asp Leu Asp 
        115                 120                 125             


Asp Gln Ala Asp Ala Ala Glu Ala Arg Arg Ala Gly Asn Leu Gly Lys 
    130                 135                 140                 


Asn Pro Asp Val Asp Thr Ser Phe Leu Pro Asp Arg Asp Arg Glu Glu 
145                 150                 155                 160 


Glu Glu Asn Arg Leu Arg Glu Glu Leu Arg Gln Glu Trp Glu Ala Gln 
                165                 170                 175     


Arg Glu Lys Val Lys Asp Glu Glu Met Glu Val Thr Phe Ser Tyr Trp 
            180                 185                 190         


Asp Gly Ser Gly His Arg Arg Thr Val Arg Val Arg Lys Gly Asn Thr 
        195                 200                 205             


Val Gln Gln Phe Leu Lys Lys Ala Leu Gln Gly Leu Arg Lys Asp Phe 
    210                 215                 220                 


Leu Glu Leu Arg Ser Ala Gly Val Glu Gln Leu Met Phe Ile Lys Glu 
225                 230                 235                 240 


Asp Leu Ile Leu Pro His Tyr His Thr Phe Tyr Asp Phe Ile Ile Ala 
                245                 250                 255     


Arg Ala Arg Gly Lys Ser Gly Pro Leu Phe Ser Phe Asp Val His Asp 
            260                 265                 270         


Asp Val Arg Leu Leu Ser Asp Ala Thr Met Glu Lys Asp Glu Ser His 
        275                 280                 285             


Ala Gly Lys Val Val Leu Arg Ser Trp Tyr Glu Lys Asn Lys His Ile 
    290                 295                 300                 


Phe Pro Ala Ser Arg Trp Glu Ala Tyr Asp Pro Glu Lys Lys Trp Asp 
305                 310                 315                 320 


Lys Tyr Thr Ile Arg 
                325 


<210>  427
<211>  7602
<212>  DNA
<213>  Homo sapiens

<400>  427
atggttctgg agcttccaat tcagaatgaa ccaccagggc aggctgcagc tgaagagaag       60

cacacctgtg ttgtccagta catcctcttc cccccacact ctacctccac caaagacagc      120

ttctcgacag atgatgacaa tgatgtggaa gtggaggccc tggagggaga ctcagagctc      180

aatctggtca ctgaggtgtg ggtggagcca cagtatgggc gagtgggacc tggccctgga      240

atctggaagc acctccagga cctgacgtat tctgagatcc cgcaagctct ccacccacgg      300

gatgctgcct gcataggctc catgctgagc tttgaatacc tgatacagct gtgtcagagc      360

aaggaatggg gtcctctgcc cccagagccg agggtctctg atggattgga tcagggagga      420

gacacctgcg tccatgagat ccctttccat tttgacctaa tgggattgct gccacagtgc      480

cagcagctcc agatgttctt cctcttgctt gccagaggtg ccgaggggcc actgctgggg      540

gttcatggga tcccgaagga gcaagcagtc ggcagcaccc aggccacagg agactccgct      600

tttacttccc tgagtgtagg tcttcctgaa actctcaagc ctctcatctc tgcccagccc      660

cctcagtggc gctgctatgc aaggcttgtg aacccccagc atgtgtttct gacttttctc      720

ccagctacct tctcagatgt ccagcgtctg gctgcctgtg gcctggaggg accccctcaa      780

gaggagacaa agcctaagtt tggggattgg agtggggctc ccagtctgaa agatctagga      840

ggaactggga tcaaagctac aaagtcccac gtccctgtcc tcagtgtgac cctggctagt      900

gacaatgccc agaatcaagg agagctaagt ccaccattcc gtcgagactt acaggcttac      960

gctgggcgtc aggcttccca gacagagagt gcggatgggc cccggacccg gtgtcctgtc     1020

tacatctaca gctgttcact ggaagcgctg agggaacaaa tggttggcat gcagccccct     1080

caggcgcccc gagacctcat cttccggact cagttcctcg accacccctc cccatcctca     1140

gcctggatgg aaccccggta caaggaggca gctaaccact gtgccctgct gcaggagcat     1200

gcacagcggt gctatgtccg tgggctattc cgcagcttgc agcaagcaca gagtgtgacc     1260

tcccaggatt tgctgacagc ggtagatgcc tgtgaggagc tactacaaga aatagacatc     1320

accccatttc tccttgcatt gtgtggccac acttggggtt tgcctcatgc acccccaagt     1380

cctggtcctc tcagccctgg gcccttcagc agcagcatgg aggagggtgc tgaacctcgg     1440

gaacgagcta tcctagcttc tgaatccagc atagagaccg aggacctaag cgagcctgag     1500

tttcagagca cccgtgtccc tggcattcca gaccctgggc cagagatctc tctgacagat     1560

gtctgccagc tcagaggaga ggcccatggt gcccttcata gcgtcatcca ggagaagttc     1620

ctagagatca gtcgtctcca cttccgcaca gtgccttcca atccccacta cttcttctat     1680

tgccctccat ccagcaggcg agaagatgag gggcctcggg acacagtaga cagaaaaatc     1740

agtgacctgg agttttcaga ggctgagctt atgggagaag aaggagacac atctgcctgc     1800

tgtgtggtca ctgagagtga cccagagcta gaggtagaat accgggagag ccgtgaatca     1860

gacctggggc ctgctgggct agactctgcc tcgctgtcag acgtagacac tgtgaatcct     1920

gatgaagact ccttcagtat cttggggggc gactcaccca ctgggcctga gagcttcctt     1980

catgacctgc caccgctctt cctgcacctc acgtgctccg tgcggctacg tgggcagcac     2040

agctcagtac ctgtgtgcag cctgcctacc tgcctgggcc aggtgctttc cagtctggag     2100

ggccccccag ttggaggccg agttcccttg agggacctca gtgtgactct ggatgtcttc     2160

atgctgactt tgcccctgga agtggagctc cccacggcct cggaccctca gcaccaccgg     2220

tcaacatctg aaagcagtgc ttcatttcca cgatccccag ggcagccatc atctttaagg     2280

tcagatgatg gcctcgggcc cccactgcca cccccagaag aggagaggca cccaggacta     2340

tccaatttgg ccacgcccca cagactggct attgagacca ccatgaatga gatccgctgg     2400

ttgttggaag atgagatggt gggggcactc cgaagagggg gcatcccaca gagtcctgcc     2460

ctgcaccgcg cagctgccca tatccatagt tctcctggac gctccacctg ccttcgccaa     2520

actctgccac tgagttttgt atttgggcca gagcgttccc tcacacaatt caaggaggag     2580

ttccgccgcc tccatctccc tggccatgtt cttcttgaag accctgacag tggcttcttc     2640

tttgtggcag ctggccaaca gccaggtggg tcccatgggg agccttcttc agcggcctgg     2700

gcttggcaca gtcatgagga cagggctgaa ggcatcgaag gggagaccct gacagccagc     2760

ccccaagcac ctgggtcccc agaggattct gagggtgtcc ccctcatcag cctgccccgc     2820

gtgccacagg gagggagtca gcctgggccc agccggggat taagtctcat gtccagtcag     2880

ggcagtgtgg actcagacca cctaggttat gatggtggca gcagtggctc agacagtgag     2940

ggtcccaatg acacccttgg tgagaaggcc cccttcacat tgcggactcc acctgggcca     3000

gcacctccac agccttcact ctcaggcctc cctgggccct gcctgcctga cttctggctc     3060

attgtccggg tcctgcagga ccgtgtggaa gtgtatgcac atgcacggag cctgattcgg     3120

gaggatgggg ggccgggcac tgagtgtcgc cacctgcagc agctcctggt gaggcgagtt     3180

ggggagatct gcagggaggt caaccagcga ctgcttcttc aagaccttca tgacagccac     3240

gtgtgtaact ctcttctggt ggccgagagt gaagaagatc tgtggcgcag tgagactccc     3300

ttccactccc gtcagcgggc accactgccc agtgatgatt atgctgctga tgagagctgt     3360

gcgccccgtg ggtacctggc agccacaatg cagtttgtcc ctggccattt ctcctgtgac     3420

gttgtgtggg gaactgtgat ccgagtccat tcacgcctca aaatggggcc cagcatgggg     3480

gtctctcggg ccatccaggc cctgcgctct gtgctcaatg ccttctctgt ggtgaaccgg     3540

aaaaacatgt ttgtttacca ggagcgagca acaaaggctg tgtactatct tcggctccta     3600

gagacatcct gcagtgaccg gccatggaaa ggggatgcgc tgcccccttc cctcgctctg     3660

tcccgaagcc aagagcccat ctactctgag gaagcctcgg gtcctcgttc tcccttagac     3720

atggtctcta gccgcagttc agatgctgct cgtcctgtgg gccaagtgga cagacatatc     3780

cagctgctgg tccatggtgt tgggcaggca ggtcctgaga tcacggatga gctcgtgcga     3840

gttctatgtc ggcgcctgga tgaggccacg ctggacgtca tcacagttat gcttgttcgg     3900

aactgcaagc tgacaccagc tgatgtggag ttcatccagc cccctggaag tctcccctca     3960

gaggtgctgc atctggccct acccacctcc tgcaggccct ggcttccagc cctggcatgg     4020

tacctacggc agaacttgct catcttcctg cactctccca agtacacaga tagcaacagc     4080

cggaaccact tccaacatcc actcccacca cagggtggcc tccctgactt ggacatctac     4140

ttgtataaca agcctggtgg acagggcact gggggcaaag gggttgcctg catcactcta     4200

gcctttgtgg atgaaggagg ggcccccttg tcactggcgt tgtggccccc ctcctctccg     4260

gggcccccag acccactgcg agaggaggaa tttgagcaac tgacccaggt catccgctgc     4320

ccggttgttg tggacagttc ttcagctcag aatggggccc cacggcttcg attggatgtg     4380

tgggaaaagg ggaacattag tattgtgcag ctggaggaga aactccgagg agcagctcgc     4440

caggccctgg ccgatgccat catcgagctt cagctgctgc cagcttcact atgtacagag     4500

gacacaccca caggaagtct caggaacgga tcgttggaaa ctaagagctc tgcaggccga     4560

gctagcacct ttccccctgc ccctgtccct ggggagcctg tgactccacc cagcaaagcg     4620

ggccggcgta gcttctggga tatgctgagt aaaacagaat gtggggattt gggttccccc     4680

aaaacaactg atgacattgt cctggatcgg ccagaagaca ctcggggccg gaggcgtcac     4740

aaaaccgaga gtgttcggac tcctggtgga gctgagcggg cgccaggctc agattctgga     4800

gcccagagac aaaagcgccg gacaacacag ctagaagagg gtgaggtggg gacccttcat     4860

cctgtgtttg cccgtgttgc tcagcgctgg atggagttta tggttcagat tggttgtgcc     4920

tcagtgtcca gaagctctgc ccacatggtg tcccggttcc tccttccatc catcctgtct     4980

gagttcaccg cactggtcac ctcaatggct ggagacacca gtgtccgcat ctttgagcag     5040

catttgggtt cagagccaga gatcttcggc ccttgttccc ctgggcaact gggcccctct     5100

ccccgccctg cagctgagcg gcatctgctg cttctgggaa ggaacttctt gcagtggagg     5160

agaccaacac agcaggctgc caaagccatg cagcgcttcg agccaggagg tgatgggagc     5220

tcagggcgaa atgctccccg gcagaggctc ttgctactag aggttgtgga caagaagcta     5280

cagctgctga cctacaactg ggctccagac ctgggggcag cattgggccg agcgctggtt     5340

cgcctggtgc agtggcagaa tgcacgagcc catctcatct tctgcctact cagccagaag     5400

cttggcctct tccatcatta tggccagttg gacttccccg tgcgagatga aaaggagcca     5460

aacccattcc tgctgccgac catggaagtg gagaccctca tccggagtgc aagtcccccg     5520

ctgagccgtg agcagggccg actgagtggg tcctctcgtg gtgggggtcc tcttcccctg     5580

gacacattcc cctttgacga ggccctaagg gatatcacgg ctgcccgccc cagctccgta     5640

cttggtcctg tgcccagacc tcctgatcct gtcacctacc atggacaaca gttcctagag     5700

atcaagatgg cagagcgcag agagctggag cgccagatga agatggaaaa cctgtttgta     5760

acctggcagc agcgttctac cccagccacc atgcccatca gtgctggaga gctggagacc     5820

ctgaagcagt catcccgcct ggtgcattac tgtgcaacag ccatgctctt cgacccagct     5880

gcctggctgc atgggccccc agagacctct ggaccccctg acgggcagcg gcgccatcgc     5940

cctgagtcag ggtctgggag ccgagaggcc cccacaagct gtgaatcctt ggatgtgtcg     6000

cccccgggag cccgtgagga gccttggctg aaggagctga gcttggcttt cctgcagcaa     6060

tatgtgcagt atctgcagag cataggtttt gtgctggtac cactgcggcc cccctcaccc     6120

gcccgcagca ccagccggcc acgggccatg gctatccttg gaacagaggg tcgaggctcc     6180

ttctcctgcc ctaaaaccaa gactgatggg agccccaaga gcactagctc tccggtaacc     6240

acctaccacc tgcagcgggc actgcctggg ggcatcatcc tcatggaact ggcattccag     6300

ggctgttact tctgtgtcaa acagtttgcc ctggaatgtt cccgaatccc aatggggcag     6360

gctgtcaact cacagctgtc catgctgttc acagaggagt gtgacaaggt gcgggacctg     6420

atgcacgtgc actcgttcag ctatgacttc catctgcgcc tcgtgcatca gcacgtgcta     6480

ggtgcccatc tggtgctgcg gcacggctac cacctcacca cctttctgcg acacttcctg     6540

gcccaccacc ctgacggacc ccactttggc cgcaatcaca tttaccaagg gacattggag     6600

ctccccacac cactcattgc tgcccaccag ctatacaact acgtggctga tcacgccagc     6660

tcttaccaca tgaagccatt gcgaatggcc cggccagggg gcccagaaca caacgagtat     6720

gccctggtgt cggcatggca cagttctggc tcctacctgg actctgaggg acttcgacac     6780

caggatgact ttgatgtgtc tctgcttgtc tgtcactgtg ctgcaccctt tgaggagcaa     6840

ggagaggctg agcggcacgt tctgcggcta cagttcttcg tggtgctcac cagccagcga     6900

gagctcttcc ccaggctcac tgctgacatg cgccgcttcc ggaagccacc cagactgccc     6960

cctgagccag aggctcctgg gagttcagct ggcagccctg gggaggcctc agggcttatt     7020

ctagcgcctg gaccggctcc tctgttccca ccactggctg cagaggtggg catggcacga     7080

gcacggctgg ctcagctggt gcggctggct ggagggcact gccgtcggga caccctttgg     7140

aagcgcctct tcttgctgga gccaccgggg cctgatcgac tgcggctagg ggggcgcctg     7200

gccctggcag agctggagga actcctagaa gcagtccatg ccaaatccat tggggacatc     7260

gacccccagc tggactgctt cctatccatg acggtctcct ggtaccagag cctgatcaaa     7320

gttctcctaa gccgcttccc ccagagctgt cgccatttcc aaagcccaga cttgggaact     7380

cagtacctgg ttgtgctgaa tcagaagttc actgactgct ttgtgctagt gtttctggac     7440

tcccacttag gaaagacgtc tctgacagtg gttttccgag agcccttccc agtacagccc     7500

caggacagcg agagcccccc tgcccaactg gtctccacct accaccacct ggagtctgtc     7560

atcaacacag cctgtttcac cctctggacc cgcctcctct ga                        7602


<210>  428
<211>  2533
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Val Leu Glu Leu Pro Ile Gln Asn Glu Pro Pro Gly Gln Ala Ala 
1               5                   10                  15      


Ala Glu Glu Lys His Thr Cys Val Val Gln Tyr Ile Leu Phe Pro Pro 
            20                  25                  30          


His Ser Thr Ser Thr Lys Asp Ser Phe Ser Thr Asp Asp Asp Asn Asp 
        35                  40                  45              


Val Glu Val Glu Ala Leu Glu Gly Asp Ser Glu Leu Asn Leu Val Thr 
    50                  55                  60                  


Glu Val Trp Val Glu Pro Gln Tyr Gly Arg Val Gly Pro Gly Pro Gly 
65                  70                  75                  80  


Ile Trp Lys His Leu Gln Asp Leu Thr Tyr Ser Glu Ile Pro Gln Ala 
                85                  90                  95      


Leu His Pro Arg Asp Ala Ala Cys Ile Gly Ser Met Leu Ser Phe Glu 
            100                 105                 110         


Tyr Leu Ile Gln Leu Cys Gln Ser Lys Glu Trp Gly Pro Leu Pro Pro 
        115                 120                 125             


Glu Pro Arg Val Ser Asp Gly Leu Asp Gln Gly Gly Asp Thr Cys Val 
    130                 135                 140                 


His Glu Ile Pro Phe His Phe Asp Leu Met Gly Leu Leu Pro Gln Cys 
145                 150                 155                 160 


Gln Gln Leu Gln Met Phe Phe Leu Leu Leu Ala Arg Gly Ala Glu Gly 
                165                 170                 175     


Pro Leu Leu Gly Val His Gly Ile Pro Lys Glu Gln Ala Val Gly Ser 
            180                 185                 190         


Thr Gln Ala Thr Gly Asp Ser Ala Phe Thr Ser Leu Ser Val Gly Leu 
        195                 200                 205             


Pro Glu Thr Leu Lys Pro Leu Ile Ser Ala Gln Pro Pro Gln Trp Arg 
    210                 215                 220                 


Cys Tyr Ala Arg Leu Val Asn Pro Gln His Val Phe Leu Thr Phe Leu 
225                 230                 235                 240 


Pro Ala Thr Phe Ser Asp Val Gln Arg Leu Ala Ala Cys Gly Leu Glu 
                245                 250                 255     


Gly Pro Pro Gln Glu Glu Thr Lys Pro Lys Phe Gly Asp Trp Ser Gly 
            260                 265                 270         


Ala Pro Ser Leu Lys Asp Leu Gly Gly Thr Gly Ile Lys Ala Thr Lys 
        275                 280                 285             


Ser His Val Pro Val Leu Ser Val Thr Leu Ala Ser Asp Asn Ala Gln 
    290                 295                 300                 


Asn Gln Gly Glu Leu Ser Pro Pro Phe Arg Arg Asp Leu Gln Ala Tyr 
305                 310                 315                 320 


Ala Gly Arg Gln Ala Ser Gln Thr Glu Ser Ala Asp Gly Pro Arg Thr 
                325                 330                 335     


Arg Cys Pro Val Tyr Ile Tyr Ser Cys Ser Leu Glu Ala Leu Arg Glu 
            340                 345                 350         


Gln Met Val Gly Met Gln Pro Pro Gln Ala Pro Arg Asp Leu Ile Phe 
        355                 360                 365             


Arg Thr Gln Phe Leu Asp His Pro Ser Pro Ser Ser Ala Trp Met Glu 
    370                 375                 380                 


Pro Arg Tyr Lys Glu Ala Ala Asn His Cys Ala Leu Leu Gln Glu His 
385                 390                 395                 400 


Ala Gln Arg Cys Tyr Val Arg Gly Leu Phe Arg Ser Leu Gln Gln Ala 
                405                 410                 415     


Gln Ser Val Thr Ser Gln Asp Leu Leu Thr Ala Val Asp Ala Cys Glu 
            420                 425                 430         


Glu Leu Leu Gln Glu Ile Asp Ile Thr Pro Phe Leu Leu Ala Leu Cys 
        435                 440                 445             


Gly His Thr Trp Gly Leu Pro His Ala Pro Pro Ser Pro Gly Pro Leu 
    450                 455                 460                 


Ser Pro Gly Pro Phe Ser Ser Ser Met Glu Glu Gly Ala Glu Pro Arg 
465                 470                 475                 480 


Glu Arg Ala Ile Leu Ala Ser Glu Ser Ser Ile Glu Thr Glu Asp Leu 
                485                 490                 495     


Ser Glu Pro Glu Phe Gln Ser Thr Arg Val Pro Gly Ile Pro Asp Pro 
            500                 505                 510         


Gly Pro Glu Ile Ser Leu Thr Asp Val Cys Gln Leu Arg Gly Glu Ala 
        515                 520                 525             


His Gly Ala Leu His Ser Val Ile Gln Glu Lys Phe Leu Glu Ile Ser 
    530                 535                 540                 


Arg Leu His Phe Arg Thr Val Pro Ser Asn Pro His Tyr Phe Phe Tyr 
545                 550                 555                 560 


Cys Pro Pro Ser Ser Arg Arg Glu Asp Glu Gly Pro Arg Asp Thr Val 
                565                 570                 575     


Asp Arg Lys Ile Ser Asp Leu Glu Phe Ser Glu Ala Glu Leu Met Gly 
            580                 585                 590         


Glu Glu Gly Asp Thr Ser Ala Cys Cys Val Val Thr Glu Ser Asp Pro 
        595                 600                 605             


Glu Leu Glu Val Glu Tyr Arg Glu Ser Arg Glu Ser Asp Leu Gly Pro 
    610                 615                 620                 


Ala Gly Leu Asp Ser Ala Ser Leu Ser Asp Val Asp Thr Val Asn Pro 
625                 630                 635                 640 


Asp Glu Asp Ser Phe Ser Ile Leu Gly Gly Asp Ser Pro Thr Gly Pro 
                645                 650                 655     


Glu Ser Phe Leu His Asp Leu Pro Pro Leu Phe Leu His Leu Thr Cys 
            660                 665                 670         


Ser Val Arg Leu Arg Gly Gln His Ser Ser Val Pro Val Cys Ser Leu 
        675                 680                 685             


Pro Thr Cys Leu Gly Gln Val Leu Ser Ser Leu Glu Gly Pro Pro Val 
    690                 695                 700                 


Gly Gly Arg Val Pro Leu Arg Asp Leu Ser Val Thr Leu Asp Val Phe 
705                 710                 715                 720 


Met Leu Thr Leu Pro Leu Glu Val Glu Leu Pro Thr Ala Ser Asp Pro 
                725                 730                 735     


Gln His His Arg Ser Thr Ser Glu Ser Ser Ala Ser Phe Pro Arg Ser 
            740                 745                 750         


Pro Gly Gln Pro Ser Ser Leu Arg Ser Asp Asp Gly Leu Gly Pro Pro 
        755                 760                 765             


Leu Pro Pro Pro Glu Glu Glu Arg His Pro Gly Leu Ser Asn Leu Ala 
    770                 775                 780                 


Thr Pro His Arg Leu Ala Ile Glu Thr Thr Met Asn Glu Ile Arg Trp 
785                 790                 795                 800 


Leu Leu Glu Asp Glu Met Val Gly Ala Leu Arg Arg Gly Gly Ile Pro 
                805                 810                 815     


Gln Ser Pro Ala Leu His Arg Ala Ala Ala His Ile His Ser Ser Pro 
            820                 825                 830         


Gly Arg Ser Thr Cys Leu Arg Gln Thr Leu Pro Leu Ser Phe Val Phe 
        835                 840                 845             


Gly Pro Glu Arg Ser Leu Thr Gln Phe Lys Glu Glu Phe Arg Arg Leu 
    850                 855                 860                 


His Leu Pro Gly His Val Leu Leu Glu Asp Pro Asp Ser Gly Phe Phe 
865                 870                 875                 880 


Phe Val Ala Ala Gly Gln Gln Pro Gly Gly Ser His Gly Glu Pro Ser 
                885                 890                 895     


Ser Ala Ala Trp Ala Trp His Ser His Glu Asp Arg Ala Glu Gly Ile 
            900                 905                 910         


Glu Gly Glu Thr Leu Thr Ala Ser Pro Gln Ala Pro Gly Ser Pro Glu 
        915                 920                 925             


Asp Ser Glu Gly Val Pro Leu Ile Ser Leu Pro Arg Val Pro Gln Gly 
    930                 935                 940                 


Gly Ser Gln Pro Gly Pro Ser Arg Gly Leu Ser Leu Met Ser Ser Gln 
945                 950                 955                 960 


Gly Ser Val Asp Ser Asp His Leu Gly Tyr Asp Gly Gly Ser Ser Gly 
                965                 970                 975     


Ser Asp Ser Glu Gly Pro Asn Asp Thr Leu Gly Glu Lys Ala Pro Phe 
            980                 985                 990         


Thr Leu Arg Thr Pro Pro Gly Pro  Ala Pro Pro Gln Pro  Ser Leu Ser 
        995                 1000                 1005             


Gly Leu  Pro Gly Pro Cys Leu  Pro Asp Phe Trp Leu  Ile Val Arg 
    1010                 1015                 1020             


Val Leu  Gln Asp Arg Val Glu  Val Tyr Ala His Ala  Arg Ser Leu 
    1025                 1030                 1035             


Ile Arg  Glu Asp Gly Gly Pro  Gly Thr Glu Cys Arg  His Leu Gln 
    1040                 1045                 1050             


Gln Leu  Leu Val Arg Arg Val  Gly Glu Ile Cys Arg  Glu Val Asn 
    1055                 1060                 1065             


Gln Arg  Leu Leu Leu Gln Asp  Leu His Asp Ser His  Val Cys Asn 
    1070                 1075                 1080             


Ser Leu  Leu Val Ala Glu Ser  Glu Glu Asp Leu Trp  Arg Ser Glu 
    1085                 1090                 1095             


Thr Pro  Phe His Ser Arg Gln  Arg Ala Pro Leu Pro  Ser Asp Asp 
    1100                 1105                 1110             


Tyr Ala  Ala Asp Glu Ser Cys  Ala Pro Arg Gly Tyr  Leu Ala Ala 
    1115                 1120                 1125             


Thr Met  Gln Phe Val Pro Gly  His Phe Ser Cys Asp  Val Val Trp 
    1130                 1135                 1140             


Gly Thr  Val Ile Arg Val His  Ser Arg Leu Lys Met  Gly Pro Ser 
    1145                 1150                 1155             


Met Gly  Val Ser Arg Ala Ile  Gln Ala Leu Arg Ser  Val Leu Asn 
    1160                 1165                 1170             


Ala Phe  Ser Val Val Asn Arg  Lys Asn Met Phe Val  Tyr Gln Glu 
    1175                 1180                 1185             


Arg Ala  Thr Lys Ala Val Tyr  Tyr Leu Arg Leu Leu  Glu Thr Ser 
    1190                 1195                 1200             


Cys Ser  Asp Arg Pro Trp Lys  Gly Asp Ala Leu Pro  Pro Ser Leu 
    1205                 1210                 1215             


Ala Leu  Ser Arg Ser Gln Glu  Pro Ile Tyr Ser Glu  Glu Ala Ser 
    1220                 1225                 1230             


Gly Pro  Arg Ser Pro Leu Asp  Met Val Ser Ser Arg  Ser Ser Asp 
    1235                 1240                 1245             


Ala Ala  Arg Pro Val Gly Gln  Val Asp Arg His Ile  Gln Leu Leu 
    1250                 1255                 1260             


Val His  Gly Val Gly Gln Ala  Gly Pro Glu Ile Thr  Asp Glu Leu 
    1265                 1270                 1275             


Val Arg  Val Leu Cys Arg Arg  Leu Asp Glu Ala Thr  Leu Asp Val 
    1280                 1285                 1290             


Ile Thr  Val Met Leu Val Arg  Asn Cys Lys Leu Thr  Pro Ala Asp 
    1295                 1300                 1305             


Val Glu  Phe Ile Gln Pro Pro  Gly Ser Leu Pro Ser  Glu Val Leu 
    1310                 1315                 1320             


His Leu  Ala Leu Pro Thr Ser  Cys Arg Pro Trp Leu  Pro Ala Leu 
    1325                 1330                 1335             


Ala Trp  Tyr Leu Arg Gln Asn  Leu Leu Ile Phe Leu  His Ser Pro 
    1340                 1345                 1350             


Lys Tyr  Thr Asp Ser Asn Ser  Arg Asn His Phe Gln  His Pro Leu 
    1355                 1360                 1365             


Pro Pro  Gln Gly Gly Leu Pro  Asp Leu Asp Ile Tyr  Leu Tyr Asn 
    1370                 1375                 1380             


Lys Pro  Gly Gly Gln Gly Thr  Gly Gly Lys Gly Val  Ala Cys Ile 
    1385                 1390                 1395             


Thr Leu  Ala Phe Val Asp Glu  Gly Gly Ala Pro Leu  Ser Leu Ala 
    1400                 1405                 1410             


Leu Trp  Pro Pro Ser Ser Pro  Gly Pro Pro Asp Pro  Leu Arg Glu 
    1415                 1420                 1425             


Glu Glu  Phe Glu Gln Leu Thr  Gln Val Ile Arg Cys  Pro Val Val 
    1430                 1435                 1440             


Val Asp  Ser Ser Ser Ala Gln  Asn Gly Ala Pro Arg  Leu Arg Leu 
    1445                 1450                 1455             


Asp Val  Trp Glu Lys Gly Asn  Ile Ser Ile Val Gln  Leu Glu Glu 
    1460                 1465                 1470             


Lys Leu  Arg Gly Ala Ala Arg  Gln Ala Leu Ala Asp  Ala Ile Ile 
    1475                 1480                 1485             


Glu Leu  Gln Leu Leu Pro Ala  Ser Leu Cys Thr Glu  Asp Thr Pro 
    1490                 1495                 1500             


Thr Gly  Ser Leu Arg Asn Gly  Ser Leu Glu Thr Lys  Ser Ser Ala 
    1505                 1510                 1515             


Gly Arg  Ala Ser Thr Phe Pro  Pro Ala Pro Val Pro  Gly Glu Pro 
    1520                 1525                 1530             


Val Thr  Pro Pro Ser Lys Ala  Gly Arg Arg Ser Phe  Trp Asp Met 
    1535                 1540                 1545             


Leu Ser  Lys Thr Glu Cys Gly  Asp Leu Gly Ser Pro  Lys Thr Thr 
    1550                 1555                 1560             


Asp Asp  Ile Val Leu Asp Arg  Pro Glu Asp Thr Arg  Gly Arg Arg 
    1565                 1570                 1575             


Arg His  Lys Thr Glu Ser Val  Arg Thr Pro Gly Gly  Ala Glu Arg 
    1580                 1585                 1590             


Ala Pro  Gly Ser Asp Ser Gly  Ala Gln Arg Gln Lys  Arg Arg Thr 
    1595                 1600                 1605             


Thr Gln  Leu Glu Glu Gly Glu  Val Gly Thr Leu His  Pro Val Phe 
    1610                 1615                 1620             


Ala Arg  Val Ala Gln Arg Trp  Met Glu Phe Met Val  Gln Ile Gly 
    1625                 1630                 1635             


Cys Ala  Ser Val Ser Arg Ser  Ser Ala His Met Val  Ser Arg Phe 
    1640                 1645                 1650             


Leu Leu  Pro Ser Ile Leu Ser  Glu Phe Thr Ala Leu  Val Thr Ser 
    1655                 1660                 1665             


Met Ala  Gly Asp Thr Ser Val  Arg Ile Phe Glu Gln  His Leu Gly 
    1670                 1675                 1680             


Ser Glu  Pro Glu Ile Phe Gly  Pro Cys Ser Pro Gly  Gln Leu Gly 
    1685                 1690                 1695             


Pro Ser  Pro Arg Pro Ala Ala  Glu Arg His Leu Leu  Leu Leu Gly 
    1700                 1705                 1710             


Arg Asn  Phe Leu Gln Trp Arg  Arg Pro Thr Gln Gln  Ala Ala Lys 
    1715                 1720                 1725             


Ala Met  Gln Arg Phe Glu Pro  Gly Gly Asp Gly Ser  Ser Gly Arg 
    1730                 1735                 1740             


Asn Ala  Pro Arg Gln Arg Leu  Leu Leu Leu Glu Val  Val Asp Lys 
    1745                 1750                 1755             


Lys Leu  Gln Leu Leu Thr Tyr  Asn Trp Ala Pro Asp  Leu Gly Ala 
    1760                 1765                 1770             


Ala Leu  Gly Arg Ala Leu Val  Arg Leu Val Gln Trp  Gln Asn Ala 
    1775                 1780                 1785             


Arg Ala  His Leu Ile Phe Cys  Leu Leu Ser Gln Lys  Leu Gly Leu 
    1790                 1795                 1800             


Phe His  His Tyr Gly Gln Leu  Asp Phe Pro Val Arg  Asp Glu Lys 
    1805                 1810                 1815             


Glu Pro  Asn Pro Phe Leu Leu  Pro Thr Met Glu Val  Glu Thr Leu 
    1820                 1825                 1830             


Ile Arg  Ser Ala Ser Pro Pro  Leu Ser Arg Glu Gln  Gly Arg Leu 
    1835                 1840                 1845             


Ser Gly  Ser Ser Arg Gly Gly  Gly Pro Leu Pro Leu  Asp Thr Phe 
    1850                 1855                 1860             


Pro Phe  Asp Glu Ala Leu Arg  Asp Ile Thr Ala Ala  Arg Pro Ser 
    1865                 1870                 1875             


Ser Val  Leu Gly Pro Val Pro  Arg Pro Pro Asp Pro  Val Thr Tyr 
    1880                 1885                 1890             


His Gly  Gln Gln Phe Leu Glu  Ile Lys Met Ala Glu  Arg Arg Glu 
    1895                 1900                 1905             


Leu Glu  Arg Gln Met Lys Met  Glu Asn Leu Phe Val  Thr Trp Gln 
    1910                 1915                 1920             


Gln Arg  Ser Thr Pro Ala Thr  Met Pro Ile Ser Ala  Gly Glu Leu 
    1925                 1930                 1935             


Glu Thr  Leu Lys Gln Ser Ser  Arg Leu Val His Tyr  Cys Ala Thr 
    1940                 1945                 1950             


Ala Met  Leu Phe Asp Pro Ala  Ala Trp Leu His Gly  Pro Pro Glu 
    1955                 1960                 1965             


Thr Ser  Gly Pro Pro Asp Gly  Gln Arg Arg His Arg  Pro Glu Ser 
    1970                 1975                 1980             


Gly Ser  Gly Ser Arg Glu Ala  Pro Thr Ser Cys Glu  Ser Leu Asp 
    1985                 1990                 1995             


Val Ser  Pro Pro Gly Ala Arg  Glu Glu Pro Trp Leu  Lys Glu Leu 
    2000                 2005                 2010             


Ser Leu  Ala Phe Leu Gln Gln  Tyr Val Gln Tyr Leu  Gln Ser Ile 
    2015                 2020                 2025             


Gly Phe  Val Leu Val Pro Leu  Arg Pro Pro Ser Pro  Ala Arg Ser 
    2030                 2035                 2040             


Thr Ser  Arg Pro Arg Ala Met  Ala Ile Leu Gly Thr  Glu Gly Arg 
    2045                 2050                 2055             


Gly Ser  Phe Ser Cys Pro Lys  Thr Lys Thr Asp Gly  Ser Pro Lys 
    2060                 2065                 2070             


Ser Thr  Ser Ser Pro Val Thr  Thr Tyr His Leu Gln  Arg Ala Leu 
    2075                 2080                 2085             


Pro Gly  Gly Ile Ile Leu Met  Glu Leu Ala Phe Gln  Gly Cys Tyr 
    2090                 2095                 2100             


Phe Cys  Val Lys Gln Phe Ala  Leu Glu Cys Ser Arg  Ile Pro Met 
    2105                 2110                 2115             


Gly Gln  Ala Val Asn Ser Gln  Leu Ser Met Leu Phe  Thr Glu Glu 
    2120                 2125                 2130             


Cys Asp  Lys Val Arg Asp Leu  Met His Val His Ser  Phe Ser Tyr 
    2135                 2140                 2145             


Asp Phe  His Leu Arg Leu Val  His Gln His Val Leu  Gly Ala His 
    2150                 2155                 2160             


Leu Val  Leu Arg His Gly Tyr  His Leu Thr Thr Phe  Leu Arg His 
    2165                 2170                 2175             


Phe Leu  Ala His His Pro Asp  Gly Pro His Phe Gly  Arg Asn His 
    2180                 2185                 2190             


Ile Tyr  Gln Gly Thr Leu Glu  Leu Pro Thr Pro Leu  Ile Ala Ala 
    2195                 2200                 2205             


His Gln  Leu Tyr Asn Tyr Val  Ala Asp His Ala Ser  Ser Tyr His 
    2210                 2215                 2220             


Met Lys  Pro Leu Arg Met Ala  Arg Pro Gly Gly Pro  Glu His Asn 
    2225                 2230                 2235             


Glu Tyr  Ala Leu Val Ser Ala  Trp His Ser Ser Gly  Ser Tyr Leu 
    2240                 2245                 2250             


Asp Ser  Glu Gly Leu Arg His  Gln Asp Asp Phe Asp  Val Ser Leu 
    2255                 2260                 2265             


Leu Val  Cys His Cys Ala Ala  Pro Phe Glu Glu Gln  Gly Glu Ala 
    2270                 2275                 2280             


Glu Arg  His Val Leu Arg Leu  Gln Phe Phe Val Val  Leu Thr Ser 
    2285                 2290                 2295             


Gln Arg  Glu Leu Phe Pro Arg  Leu Thr Ala Asp Met  Arg Arg Phe 
    2300                 2305                 2310             


Arg Lys  Pro Pro Arg Leu Pro  Pro Glu Pro Glu Ala  Pro Gly Ser 
    2315                 2320                 2325             


Ser Ala  Gly Ser Pro Gly Glu  Ala Ser Gly Leu Ile  Leu Ala Pro 
    2330                 2335                 2340             


Gly Pro  Ala Pro Leu Phe Pro  Pro Leu Ala Ala Glu  Val Gly Met 
    2345                 2350                 2355             


Ala Arg  Ala Arg Leu Ala Gln  Leu Val Arg Leu Ala  Gly Gly His 
    2360                 2365                 2370             


Cys Arg  Arg Asp Thr Leu Trp  Lys Arg Leu Phe Leu  Leu Glu Pro 
    2375                 2380                 2385             


Pro Gly  Pro Asp Arg Leu Arg  Leu Gly Gly Arg Leu  Ala Leu Ala 
    2390                 2395                 2400             


Glu Leu  Glu Glu Leu Leu Glu  Ala Val His Ala Lys  Ser Ile Gly 
    2405                 2410                 2415             


Asp Ile  Asp Pro Gln Leu Asp  Cys Phe Leu Ser Met  Thr Val Ser 
    2420                 2425                 2430             


Trp Tyr  Gln Ser Leu Ile Lys  Val Leu Leu Ser Arg  Phe Pro Gln 
    2435                 2440                 2445             


Ser Cys  Arg His Phe Gln Ser  Pro Asp Leu Gly Thr  Gln Tyr Leu 
    2450                 2455                 2460             


Val Val  Leu Asn Gln Lys Phe  Thr Asp Cys Phe Val  Leu Val Phe 
    2465                 2470                 2475             


Leu Asp  Ser His Leu Gly Lys  Thr Ser Leu Thr Val  Val Phe Arg 
    2480                 2485                 2490             


Glu Pro  Phe Pro Val Gln Pro  Gln Asp Ser Glu Ser  Pro Pro Ala 
    2495                 2500                 2505             


Gln Leu  Val Ser Thr Tyr His  His Leu Glu Ser Val  Ile Asn Thr 
    2510                 2515                 2520             


Ala Cys  Phe Thr Leu Trp Thr  Arg Leu Leu 
    2525                 2530             


<210>  429
<211>  3294
<212>  DNA
<213>  Homo sapiens

<400>  429
atgatggata tttacgtatg tttgaaacga ccatcctgga tggtggacaa taaaagaatg       60

aggactgctt caaatttcca gtggctgtta tcaacattta ttcttctata tctaatgaat      120

caagtaaata gccagaaaaa gggggctcct catgatttga agtgtgtaac taacaatttg      180

caagtgtgga actgttcttg gaaagcaccc tctggaacag gccgtggtac tgattatgaa      240

gtttgcattg aaaacaggtc ccgttcttgt tatcagttgg agaaaaccag tattaaaatt      300

ccagctcttt cacatggtga ttatgaaata acaataaatt ctctacatga ttttggaagt      360

tctacaagta aattcacact aaatgaacaa aacgtttcct taattccaga tactccagag      420

atcttgaatt tgtctgctga tttctcaacc tctacattat acctaaagtg gaacgacagg      480

ggttcagttt ttccacaccg ctcaaatgtt atctgggaaa ttaaagttct acgtaaagag      540

agtatggagc tcgtaaaatt agtgacccac aacacaactc tgaatggcaa agatacactt      600

catcactgga gttgggcctc agatatgccc ttggaatgtg ccattcattt tgtggaaatt      660

agatgctaca ttgacaatct tcatttttct ggtctcgaag agtggagtga ctggagccct      720

gtgaagaaca tttcttggat acctgattct cagactaagg tttttcctca agataaagtg      780

atacttgtag gctcagacat aacattttgt tgtgtgagtc aagaaaaagt gttatcagca      840

ctgattggcc atacaaactg ccccttgatc catcttgatg gggaaaatgt tgcaatcaag      900

attcgtaata tttctgtttc tgcaagtagt ggaacaaatg tagtttttac aaccgaagat      960

aacatatttg gaaccgttat ttttgctgga tatccaccag atactcctca acaactgaat     1020

tgtgagacac atgatttaaa agaaattata tgtagttgga atccaggaag ggtgacagcg     1080

ttggtgggcc cacgtgctac aagctacact ttagttgaaa gtttttcagg aaaatatgtt     1140

agacttaaaa gagctgaagc acctacaaac gaaagctatc aattattatt tcaaatgctt     1200

ccaaatcaag aaatatataa ttttactttg aatgctcaca atccgctggg tcgatcacaa     1260

tcaacaattt tagttaatat aactgaaaaa gtttatcccc atactcctac ttcattcaaa     1320

gtgaaggata ttaattcaac agctgttaaa ctttcttggc atttaccagg caactttgca     1380

aagattaatt ttttatgtga aattgaaatt aagaaatcta attcagtaca agagcagcgg     1440

aatgtcacaa tcaaaggagt agaaaattca agttatcttg ttgctctgga caagttaaat     1500

ccatacactc tatatacttt tcggattcgt tgttctactg aaactttctg gaaatggagc     1560

aaatggagca ataaaaaaca acatttaaca acagaagcca gtccttcaaa ggggcctgat     1620

acttggagag agtggagttc tgatggaaaa aatttaataa tctattggaa gcctttaccc     1680

attaatgaag ctaatggaaa aatactttcc tacaatgtat cgtgttcatc agatgaggaa     1740

acacagtccc tttctgaaat ccctgatcct cagcacaaag cagagatacg acttgataag     1800

aatgactaca tcatcagcgt agtggctaaa aattctgtgg gctcatcacc accttccaaa     1860

atagcgagta tggaaattcc aaatgatgat ctcaaaatag aacaagttgt tgggatggga     1920

aaggggattc tcctcacctg gcattacgac cccaacatga cttgcgacta cgtcattaag     1980

tggtgtaact cgtctcggtc ggaaccatgc cttatggact ggagaaaagt tccctcaaac     2040

agcactgaaa ctgtaataga atctgatgag tttcgaccag gtataagata taattttttc     2100

ctgtatggat gcagaaatca aggatatcaa ttattacgct ccatgattgg atatatagaa     2160

gaattggctc ccattgttgc accaaatttt actgttgagg atacttctgc agattcgata     2220

ttagtaaaat gggaagacat tcctgtggaa gaacttagag gctttttaag aggatatttg     2280

ttttactttg gaaaaggaga aagagacaca tctaagatga gggttttaga atcaggtcgt     2340

tctgacataa aagttaagaa tattactgac atatcccaga agacactgag aattgctgat     2400

cttcaaggta aaacaagtta ccacctggtc ttgcgagcct atacagatgg tggagtgggc     2460

ccggagaaga gtatgtatgt ggtgacaaag gaaaattctg tgggattaat tattgccatt     2520

ctcatcccag tggcagtggc tgtcattgtt ggagtggtga caagtatcct ttgctatcgg     2580

aaacgagaat ggattaaaga aaccttctac cctgatattc caaatccaga aaactgtaaa     2640

gcattacagt ttcaaaagag tgtctgtgag ggaagcagtg ctcttaaaac attggaaatg     2700

aatccttgta ccccaaataa tgttgaggtt ctggaaactc gatcagcatt tcctaaaata     2760

gaagatacag aaataatttc cccagtagct gagcgtcctg aagatcgctc tgatgcagag     2820

cctgaaaacc atgtggttgt gtcctattgt ccacccatca ttgaggaaga aataccaaac     2880

ccagccgcag atgaagctgg agggactgca caggttattt acattgatgt tcagtcgatg     2940

tatcagcctc aagcaaaacc agaagaagaa caagaaaatg accctgtagg aggggcaggc     3000

tataagccac agatgcacct ccccattaat tctactgtgg aagatatagc tgcagaagag     3060

gacttagata aaactgcggg ttacagacct caggccaatg taaatacatg gaatttagtg     3120

tctccagact ctcctagatc catagacagc aacagtgaga ttgtctcatt tggaagtcca     3180

tgctccatta attcccgaca atttttgatt cctcctaaag atgaagactc tcctaaatct     3240

aatggaggag ggtggtcctt tacaaacttt tttcagaaca aaccaaacga ttaa           3294


<210>  430
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  431
<211>  2892
<212>  DNA
<213>  Homo sapiens

<400>  431
atgggcctcc ccgagccggg ccctctccgg cttctggcgc tgctgctgct gctgctgctg       60

ctgctgctgc tgcagctcca gcatcttgcg gcggcagcgg ctgatccgct gctcggcggc      120

caagggccgg ccaaggattg cgaaaaggac caattccagt gccggaacga gcgctgcatc      180

ccctctgtgt ggagatgcga cgaggacgat gactgcttag accacagcga cgaggacgac      240

tgccccaaga agacctgtgc agacagtgac ttcacctgtg acaacggcca ctgcatccac      300

gaacggtgga agtgtgacgg cgaggaggag tgtcctgatg gctccgatga gtccgaggcc      360

acttgcacca agcaggtgtg tcctgcagag aagctgagct gtggacccac cagccacaag      420

tgtgtacctg cctcgtggcg ctgcgacggg gagaaggact gcgagggtgg agcggatgag      480

gccggctgtg ctaccttgtg cgccccgcac gagttccagt gcggcaaccg ctcgtgcctg      540

gccgccgtgt tcgtgtgcga cggcgacgac gactgtggtg acggcagcga tgagcgcggc      600

tgtgcagacc cggcctgcgg gccccgcgag ttccgctgcg gcggcgatgg cggcggcgcc      660

tgcatcccgg agcgctgggt ctgcgaccgc cagtttgact gcgaggaccg ctcggacgag      720

gcagccgagc tctgcggccg tccgggcccc ggggccacgt ccgcgcccgc cgcctgcgcc      780

accgcctccc agttcgcctg ccgcagcggc gagtgcgtgc acctgggctg gcgctgcgac      840

ggcgaccgcg actgcaaaga caaatcggac gaggccgact gcccactggg cacctgccgt      900

ggggacgagt tccagtgtgg ggatgggaca tgtgtccttg caatcaagca ctgcaaccag      960

gagcaggact gtccagatgg gagtgatgaa gctggctgcc tacaggggct gaacgagtgt     1020

ctgcacaaca atggcggctg ctcacacatc tgcactgacc tcaagattgg ctttgaatgc     1080

acgtgcccag caggcttcca gctcctggac cagaagacct gtggcgacat tgatgagtgc     1140

aaggacccag atgcctgcag ccagatctgt gtcaattaca agggctattt taagtgtgag     1200

tgctaccctg gctacgagat ggacctactg accaagaact gcaaggctgc tgctggcaag     1260

agcccatccc taatcttcac caaccggcac gaggtgcgga ggatcgacct ggtgaagcgg     1320

aactattcac gcctcatccc catgctcaag aatgtcgtgg cactagatgt ggaagttgcc     1380

accaatcgca tctactggtg tgacctctcc taccgtaaga tctatagcgc ctacatggac     1440

aaggccagtg acccgaaaga gcaggaggtc ctcattgacg agcagttgca ctctccagag     1500

ggcctggcag tggactgggt ccacaagcac atctactgga ctgactcggg caataagacc     1560

atctcagtgg ccacagttga tggtggccgc cgacgcactc tcttcagccg taacctcagt     1620

gaaccccggg ccatcgctgt tgaccccctg cgagggttca tgtattggtc tgactggggg     1680

gaccaggcca agattgagaa atctgggctc aacggtgtgg accggcaaac actggtgtca     1740

gacaatattg aatggcccaa cggaatcacc ctggatctgc tgagccagcg cttgtactgg     1800

gtagactcca agctacacca actgtccagc attgacttca gtggaggcaa cagaaagacg     1860

ctgatctcct ccactgactt cctgagccac ccttttggga tagctgtgtt tgaggacaag     1920

gtgttctgga cagacctgga gaacgaggcc attttcagtg caaatcggct caatggcctg     1980

gaaatctcca tcctggctga gaacctcaac aacccacatg acattgtcat cttccatgag     2040

ctgaagcagc caagagctcc agatgcctgt gagctgagtg tccagcctaa tggaggctgt     2100

gaatacctgt gccttcctgc tcctcagatc tccagccact ctcccaagta cacatgtgcc     2160

tgtcctgaca caatgtggct gggtccagac atgaagaggt gctaccgagc acctcaatct     2220

acctcaacta cgacgttagc ttctaccatg acgaggacag tacctgccac cacaagagcc     2280

cccgggacca ccgtccacag atccacctac cagaaccaca gcacagagac accaagcctg     2340

acagctgcag tcccaagctc agttagtgtc cccagggctc ccagcatcag cccgtctacc     2400

ctaagccctg caaccagcaa ccactcccag cactatgcaa atgaagacag taagatgggc     2460

tcaacagtca ctgccgctgt tatcgggatc atcgtgccca tagtggtgat agccctcctg     2520

tgcatgagtg gatacctgat ctggagaaac tggaagcgga agaacaccaa aagcatgaat     2580

tttgacaacc cagtctacag gaaaacaaca gaagaagaag acgaagatga gctccatata     2640

gggagaactg ctcagattgg ccatgtctat cctgcagcaa tcagcagctt tgatcgccca     2700

ctgtgggcag agccctgtct tggggagacc agagaaccgg aagacccagc ccctgccctc     2760

aaggagcttt ttgtcttgcc gggggaacca aggtcacagc tgcaccaact cccgaagaac     2820

cctctttccg agctgcctgt cgtcaaatcc aagcgagtgg cattaagcct tgaagatgat     2880

ggactaccct ga                                                         2892


<210>  432
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Ala Ile Ser Ser 
                885                 890                 895     


Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu 
            900                 905                 910         


Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly 
        915                 920                 925             


Glu Pro Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu 
    930                 935                 940                 


Leu Pro Val Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp 
945                 950                 955                 960 


Gly Leu Pro 
            


<210>  433
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  433
atgaggcttc gggagccgct cctgagcggc agcgccgcga tgccaggcgc gtccctacag       60

cgggcctgcc gcctgctcgt ggccgtctgc gctctgcacc ttggcgtcac cctcgtttac      120

tacctggctg gccgcgacct gagccgcctg ccccaactgg tcggagtctc cacaccgctg      180

cagggcggct cgaacagtgc cgccgccatc gggcagtcct ccggggagct ccggaccgga      240

ggggcccggc cgccgcctcc tctaggcgcc tcctcccagc cgcgcccggg tggcgactcc      300

agcccagtcg tggattctgg ccctggcccc gctagcaact tgacctcggt cccagtgccc      360

cacaccaccg cactgtcgct gcccgcctgc cctgaggagt ccccgctgct tgtgggcccc      420

atgctgattg agtttaacat gcctgtggac ctggagctcg tggcaaagca gaacccaaat      480

gtgaagatgg gcggccgcta tgcccccagg gactgcgtct ctcctcacaa ggtggccatc      540

atcattccat tccgcaaccg gcaggagcac ctcaagtact ggctatatta tttgcaccca      600

gtcctgcagc gccagcagct ggactatggc atctatgtta tcaaccaggc gggagacact      660

atattcaatc gtgctaagct cctcaatgtt ggctttcaag aagccttgaa ggactatgac      720

tacacctgct ttgtgtttag tgacgtggac ctcattccaa tgaatgacca taatgcgtac      780

aggtgttttt cacagccacg gcacatttcc gttgcaatgg ataagtttgg attcagccta      840

ccttatgttc agtattttgg aggtgtctct gctctaagta aacaacagtt tctaaccatc      900

aatggatttc ctaataatta ttggggctgg ggaggagaag atgatgacat ttttaacaga      960

ttagttttta gaggcatgtc tatatctcgc ccaaatgctg tggtcgggag gtgtcgcatg     1020

atccgccact caagagacaa gaaaaatgaa cccaatcctc agaggtttga ccgaattgca     1080

cacacaaagg agacaatgct ctctgatggt ttgaactcac tcacctacca ggtgctggat     1140

gtacagagat acccattgta tacccaaatc acagtggaca tcgggacacc gagctag        1197


<210>  434
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  435
<211>  5973
<212>  DNA
<213>  Homo sapiens

<400>  435
atgtttcgga atagtctcaa gatgctgctt actggtggga aatcaagtcg taaaaacagg       60

tcaagtgatg gagggagcga ggaaccaccg gatcgaagac agtcaagtgt agactctcgc      120

caaagccgct ctgggcaagg tggcatctcc acagaaagcg actgtgcttt tgagccagac      180

tacgctgtcc cgccacttcc agtgagtgaa ggtgatgctg aacaggagct tggcccccct      240

ccatctgtag atgaggcagc aaacacactc atgactcgtc tgggtttcct ccttggagag      300

aaagtcacag aagttcagcc aggtgaccaa tacagcatgg aagtacagga tgaaaatcag      360

acctcagcaa tcacccagcg gataagtcct tgttccactc tgactagcag cactgcctct      420

ccaccagcca gtagcccctg ctctacactc ccacccatca gtacaaatgc aactgccaag      480

gactgcagct atggggctgt tactagtcca acctctaccc ttgaaagcag agatagtggc      540

atcattgcta cattaacaag ctattctgaa aatgtggaac gcacaaaata tgctggggaa      600

agcagtaaag aattaggatc tggaggaaac ataaaacctt ggcagtctca aaaatccagc      660

atggactcct gtttgtatcg agtagatgaa aacatgactg cttccaccta tagtctgaat      720

aagatcccag agagaaattt ggaaacagtg ttatctcaat cagtacagtc tattcctttg      780

tatctcatgc cacggccaaa ttcagtagca gccaccagct ctgcccactt ggaagacctt      840

gcttacctgg atgagcagag acatacacct ttgagaactt ctctacgaat gccaagacag      900

agcatgggtg gtgctcgcac acagcaggat ttaagagttc gctttgcacc ttataggcct      960

ccagatatct ccttgaagcc tctgctcttt gaagtgccca gcatcactac agagtcagtg     1020

tttgttggcc gagattgggt tttccacgaa atagatgctc aacttcaaag ttcaaatgcc     1080

agcgtgaacc aaggagtagt gattgtggga aacattggat tcggcaaaac tgccatcatc     1140

tccagactgg tggccctcag ctgccatggt acaaggatga gacagatcgc ctcagacagc     1200

ccacatgcct cccccaaaca tgtggatgcc aacagagagc tgccactcac acagccacct     1260

tcagcccact catctatcac cagtggaagc tgcccaggaa ctccggaaat gcgcaggcgg     1320

caggaggagg ctatgcgaag actagcctcg caggtggttg cctatcacta ttgtcaagca     1380

gataatgcct acacttgctt ggtgccagaa tttgtccaca atgttgctgc cttgctctgc     1440

cgctcacctc agctgacagc ctatcgggag cagcttcttc gggaacctca cctgcagagc     1500

atgctgagcc ttcgttcctg tgttcaagac cccatggcct ccttccggag gggagttctg     1560

gagccactag aaaatctcca taaagagaga aaaatcccag atgaagattt catcatttta     1620

attgatggat taaatgaagc agaatttcac aaaccggatt atggggatac aattgtatcg     1680

tttctgagta aaatgatcgg aaagtttcct tcttggctca aactaattgt aacagttagg     1740

accagtttac aggaaattac caagctgctg cctttccata ggattttttt ggatcgacta     1800

gaagagaatg aagccataga ccaggacctg caggcttaca tcctgcaccg gatacacagc     1860

agctcagaga tccagaataa catttcactt aatggcaaaa tggacaatac tacatttggc     1920

aaactcagtt ctcatctcaa gaccctcagt caagggtcct atctatatct gaaacttaca     1980

tttgacctca tagagaaagg ctatctagtg ttaaagagct ctagctacaa agtagttcct     2040

gtttcgctct cagaggttta tttactccag tgcaatatga agttcccaac ccagtcttcc     2100

tttgaccggg tgatgcctct cctgaatgtg gcagtggcct ctctccaccc actgactgat     2160

gagcatatct tccaggccat caatgctggg agcattgaag gcacactaga atgggaggat     2220

tttcagcaga gaatggagaa cctctccatg ttcctaatca agcgcagaga catgactcgt     2280

atgtttgtac atccttcttt tcgagaatgg cttatctgga gagaagaagg agagaaaacc     2340

aaatttctct gtgatccgag gagtggtcac acgttacttg ccttctggtt ttcccgccaa     2400

gagggaaaac taaaccgaca gcagactatt gaactgggac atcacatcct caaagcacac     2460

atttttaagg gtttgagtaa aaaagttggt gtatcatcct ccatcctcca aggtctctgg     2520

atctcttata gcacagaagg tctttccatg gcactggcgt ctttacgaaa tctctacact     2580

ccaaatataa aggtcagccg actgctgatt ttgggaggtg ccaatattaa ttaccggaca     2640

gaggttttaa ataatgctcc aattctatgt gttcagtccc atcttggtta cacagaaatg     2700

gtagccctgc tgctggagtt cggggccaac gtggatgcct cttctgaaag tggcctgact     2760

cccctgggat atgctgcagc agcagggtac ctgagcattg tggtgctgct gtgcaagaaa     2820

cgggccaagg tggatcattt ggataagaac gggcagtgtg ctttggttca tgctgcactc     2880

cgaggtcatc tggaggttgt caagtttttg attcagtgtg actggacgat ggccggccag     2940

cagcaaggag tatttaagaa gagccatgcc atccaacagg ccctcattgc tgcagccagc     3000

atgggttata ctgagattgt ctcctaccta cttgatcttc cagaaaaaga tgaagaggaa     3060

gtagagcgag cacagatcaa cagctttgac agtctctggg gagagacagc cctaacagct     3120

gcagccggaa ggggcaaact ggaggtgtgc cgtttgctct tggaacaagg ggcggcagtg     3180

gcccagccaa accgccgagg agcagtgcca ctattcagca cagtgcgcca gggccactgg     3240

cagattgttg atcttttact cacccatgga gctgatgtca acatggcaga caagcagggc     3300

cgcactcccc tgatgatggc tgcttccgaa ggccatctag gaaccgtgga ctttctgctt     3360

gcacaaggtg cctccattgc tcttatggac aaagaaggat tgacagccct cagctgggct     3420

tgtttgaagg gccatctctc agtagtacgt tctctggtgg ataacggagc tgccacagac     3480

catgctgaca agaatggccg taccccactg gatctggcag ctttctatgg cgatgctgag     3540

gtggtccagt tcctggtaga tcatggggcc atgatcgagc acgttgacta cagtggaatg     3600

cgccctttgg atagggcagt ggggtgccgg aacacttctg ttgttgtcac tcttctgaag     3660

aaaggagcca agataggtcc agccacatgg gcgatggcca cctccaagcc agacatcatg     3720

atcatcctgt tgagcaagct gatggaagag ggggacatgt tttataagaa aggtaaagta     3780

aaggaagctg cccagcgcta ccagtacgcc ctgaagaagt tccctagaga agggtttggt     3840

gaggacttga aaactttccg ggaactaaag gtgtctctcc tcctcaacct ctctcggtgt     3900

cgcaggaaaa tgaacgattt tggaatggcg gaggaatttg ctactaaggc cctggagctg     3960

aaaccgaaat cttatgaagc ttactatgcg agagcaaggg caaaacgcag cagcagacag     4020

ttcgcagcag ccttagagga cctgaacgag gccatcaagc tgtgtcccaa caaccgtgag     4080

atccagagac ttctgctgag agtggaagaa gagtgtagac agatgcagca gccacagcag     4140

ccaccgccgc caccgcagcc tcagcagcag ttgccggaag aagcagaacc tgagccacag     4200

catgaagaca tatactctgt acaggatata ttcgaggagg agtacctgga acaggatgtt     4260

gaaaatgttt ccattggcct ccagacagag gcccggccca gccaggggct cccggtcatc     4320

cagagcccac cctcctctcc cccgcatcgg gactcagcct acatctccag ctcacctctt     4380

ggctctcatc aggtttttga cttccggtcc agtagttctg taggctctcc cactagacag     4440

acctatcagt ccacctcacc tgccctttct ccaactcatc agaactcaca ttacaggcct     4500

agcccaccac acacttcccc ggctcatcag ggaggatctt accgtttcag cccccctcct     4560

gtgggaggac agggcaaaga atacccaagc cctccccctt cccctctccg gagaggccct     4620

cagtatcggg ccagccctcc agctgaaagt atgagtgtct atagatccca gtctggttca     4680

cccgtgcgct atcagcagga aacaagcgtc agtcagcttc ctggcagacc caaatctcca     4740

ttatccaaaa tggcccagcg gccctaccag atgcctcagc tccctgtggc agttccccag     4800

caagggctca ggctacagcc tgccaaggcc cagattgtga gaagtaacca gcccagccca     4860

gccgtccatt caagcaccgt catccccaca ggagcctatg gccaagtagc ccattcaatg     4920

gccagtaaat accagtcttc acaaggagac ataggagtca gccagagccg gttggtttat     4980

caagggtcaa ttgggggaat cgtaggggat ggaaggccgg tgcagcatgt ccaagccagc     5040

ctgagtgcag gcgccatctg tcagcatgga ggattgacca aagaggatct tccacagcga     5100

ccttcctcag cataccgagg tggcgtgaga tacagccaga caccacagat cggacgcagc     5160

cagtcagcat cctattaccc agtctgtcac tcaaaactag atctggagcg ctcctccagc     5220

caactaggtt cccctgatgt gtcgcattta atcagaagac ctatcagtgt caaccctaac     5280

gaaatcaaac cgcacccgcc aactcccagg ccgttgctgc attcccaaag tgtaggcctt     5340

cgcttctctc catctagcaa tagtatctcc tccacctcca acctaactcc gaccttccgg     5400

ccatcttctt ccatccagca aatggagatc ccactgaaac ctgcatatga gaggtcatgt     5460

gacgagctgt cgccagtgtc tccaactcaa ggaggttacc ccagtgagcc cacccgatcc     5520

aggaccacac cattcatggg gatcatagat aaaacagcac ggactcagca gtacccccac     5580

ctccaccagc agaatcggac ctgggcagtg tcatctgtgg acaccgtcct cagtcccacg     5640

tctccaggca acctgcctca gcctgagtcc ttcagtccac catcatccat cagcaacatt     5700

gccttttata acaaaaccaa caatgcacag aatggccatt tgctggagga cgattattac     5760

agcccccatg ggatgctggc taacgggtct cgtggagacc tcttggagcg agtcagccag     5820

gcctcctcct atcccgacgt gaaggtagct cggactctac ctgtggctca ggcataccag     5880

gacaacctgt acaggcagct gtcccgagac tctcggcaag ggcagacatc ccctatcaaa     5940

ccaaagagac cgttcgtgga gtctaatgtt taa                                  5973


<210>  436
<211>  1990
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Phe Arg Asn Ser Leu Lys Met Leu Leu Thr Gly Gly Lys Ser Ser 
1               5                   10                  15      


Arg Lys Asn Arg Ser Ser Asp Gly Gly Ser Glu Glu Pro Pro Asp Arg 
            20                  25                  30          


Arg Gln Ser Ser Val Asp Ser Arg Gln Ser Arg Ser Gly Gln Gly Gly 
        35                  40                  45              


Ile Ser Thr Glu Ser Asp Cys Ala Phe Glu Pro Asp Tyr Ala Val Pro 
    50                  55                  60                  


Pro Leu Pro Val Ser Glu Gly Asp Ala Glu Gln Glu Leu Gly Pro Pro 
65                  70                  75                  80  


Pro Ser Val Asp Glu Ala Ala Asn Thr Leu Met Thr Arg Leu Gly Phe 
                85                  90                  95      


Leu Leu Gly Glu Lys Val Thr Glu Val Gln Pro Gly Asp Gln Tyr Ser 
            100                 105                 110         


Met Glu Val Gln Asp Glu Asn Gln Thr Ser Ala Ile Thr Gln Arg Ile 
        115                 120                 125             


Ser Pro Cys Ser Thr Leu Thr Ser Ser Thr Ala Ser Pro Pro Ala Ser 
    130                 135                 140                 


Ser Pro Cys Ser Thr Leu Pro Pro Ile Ser Thr Asn Ala Thr Ala Lys 
145                 150                 155                 160 


Asp Cys Ser Tyr Gly Ala Val Thr Ser Pro Thr Ser Thr Leu Glu Ser 
                165                 170                 175     


Arg Asp Ser Gly Ile Ile Ala Thr Leu Thr Ser Tyr Ser Glu Asn Val 
            180                 185                 190         


Glu Arg Thr Lys Tyr Ala Gly Glu Ser Ser Lys Glu Leu Gly Ser Gly 
        195                 200                 205             


Gly Asn Ile Lys Pro Trp Gln Ser Gln Lys Ser Ser Met Asp Ser Cys 
    210                 215                 220                 


Leu Tyr Arg Val Asp Glu Asn Met Thr Ala Ser Thr Tyr Ser Leu Asn 
225                 230                 235                 240 


Lys Ile Pro Glu Arg Asn Leu Glu Thr Val Leu Ser Gln Ser Val Gln 
                245                 250                 255     


Ser Ile Pro Leu Tyr Leu Met Pro Arg Pro Asn Ser Val Ala Ala Thr 
            260                 265                 270         


Ser Ser Ala His Leu Glu Asp Leu Ala Tyr Leu Asp Glu Gln Arg His 
        275                 280                 285             


Thr Pro Leu Arg Thr Ser Leu Arg Met Pro Arg Gln Ser Met Gly Gly 
    290                 295                 300                 


Ala Arg Thr Gln Gln Asp Leu Arg Val Arg Phe Ala Pro Tyr Arg Pro 
305                 310                 315                 320 


Pro Asp Ile Ser Leu Lys Pro Leu Leu Phe Glu Val Pro Ser Ile Thr 
                325                 330                 335     


Thr Glu Ser Val Phe Val Gly Arg Asp Trp Val Phe His Glu Ile Asp 
            340                 345                 350         


Ala Gln Leu Gln Ser Ser Asn Ala Ser Val Asn Gln Gly Val Val Ile 
        355                 360                 365             


Val Gly Asn Ile Gly Phe Gly Lys Thr Ala Ile Ile Ser Arg Leu Val 
    370                 375                 380                 


Ala Leu Ser Cys His Gly Thr Arg Met Arg Gln Ile Ala Ser Asp Ser 
385                 390                 395                 400 


Pro His Ala Ser Pro Lys His Val Asp Ala Asn Arg Glu Leu Pro Leu 
                405                 410                 415     


Thr Gln Pro Pro Ser Ala His Ser Ser Ile Thr Ser Gly Ser Cys Pro 
            420                 425                 430         


Gly Thr Pro Glu Met Arg Arg Arg Gln Glu Glu Ala Met Arg Arg Leu 
        435                 440                 445             


Ala Ser Gln Val Val Ala Tyr His Tyr Cys Gln Ala Asp Asn Ala Tyr 
    450                 455                 460                 


Thr Cys Leu Val Pro Glu Phe Val His Asn Val Ala Ala Leu Leu Cys 
465                 470                 475                 480 


Arg Ser Pro Gln Leu Thr Ala Tyr Arg Glu Gln Leu Leu Arg Glu Pro 
                485                 490                 495     


His Leu Gln Ser Met Leu Ser Leu Arg Ser Cys Val Gln Asp Pro Met 
            500                 505                 510         


Ala Ser Phe Arg Arg Gly Val Leu Glu Pro Leu Glu Asn Leu His Lys 
        515                 520                 525             


Glu Arg Lys Ile Pro Asp Glu Asp Phe Ile Ile Leu Ile Asp Gly Leu 
    530                 535                 540                 


Asn Glu Ala Glu Phe His Lys Pro Asp Tyr Gly Asp Thr Ile Val Ser 
545                 550                 555                 560 


Phe Leu Ser Lys Met Ile Gly Lys Phe Pro Ser Trp Leu Lys Leu Ile 
                565                 570                 575     


Val Thr Val Arg Thr Ser Leu Gln Glu Ile Thr Lys Leu Leu Pro Phe 
            580                 585                 590         


His Arg Ile Phe Leu Asp Arg Leu Glu Glu Asn Glu Ala Ile Asp Gln 
        595                 600                 605             


Asp Leu Gln Ala Tyr Ile Leu His Arg Ile His Ser Ser Ser Glu Ile 
    610                 615                 620                 


Gln Asn Asn Ile Ser Leu Asn Gly Lys Met Asp Asn Thr Thr Phe Gly 
625                 630                 635                 640 


Lys Leu Ser Ser His Leu Lys Thr Leu Ser Gln Gly Ser Tyr Leu Tyr 
                645                 650                 655     


Leu Lys Leu Thr Phe Asp Leu Ile Glu Lys Gly Tyr Leu Val Leu Lys 
            660                 665                 670         


Ser Ser Ser Tyr Lys Val Val Pro Val Ser Leu Ser Glu Val Tyr Leu 
        675                 680                 685             


Leu Gln Cys Asn Met Lys Phe Pro Thr Gln Ser Ser Phe Asp Arg Val 
    690                 695                 700                 


Met Pro Leu Leu Asn Val Ala Val Ala Ser Leu His Pro Leu Thr Asp 
705                 710                 715                 720 


Glu His Ile Phe Gln Ala Ile Asn Ala Gly Ser Ile Glu Gly Thr Leu 
                725                 730                 735     


Glu Trp Glu Asp Phe Gln Gln Arg Met Glu Asn Leu Ser Met Phe Leu 
            740                 745                 750         


Ile Lys Arg Arg Asp Met Thr Arg Met Phe Val His Pro Ser Phe Arg 
        755                 760                 765             


Glu Trp Leu Ile Trp Arg Glu Glu Gly Glu Lys Thr Lys Phe Leu Cys 
    770                 775                 780                 


Asp Pro Arg Ser Gly His Thr Leu Leu Ala Phe Trp Phe Ser Arg Gln 
785                 790                 795                 800 


Glu Gly Lys Leu Asn Arg Gln Gln Thr Ile Glu Leu Gly His His Ile 
                805                 810                 815     


Leu Lys Ala His Ile Phe Lys Gly Leu Ser Lys Lys Val Gly Val Ser 
            820                 825                 830         


Ser Ser Ile Leu Gln Gly Leu Trp Ile Ser Tyr Ser Thr Glu Gly Leu 
        835                 840                 845             


Ser Met Ala Leu Ala Ser Leu Arg Asn Leu Tyr Thr Pro Asn Ile Lys 
    850                 855                 860                 


Val Ser Arg Leu Leu Ile Leu Gly Gly Ala Asn Ile Asn Tyr Arg Thr 
865                 870                 875                 880 


Glu Val Leu Asn Asn Ala Pro Ile Leu Cys Val Gln Ser His Leu Gly 
                885                 890                 895     


Tyr Thr Glu Met Val Ala Leu Leu Leu Glu Phe Gly Ala Asn Val Asp 
            900                 905                 910         


Ala Ser Ser Glu Ser Gly Leu Thr Pro Leu Gly Tyr Ala Ala Ala Ala 
        915                 920                 925             


Gly Tyr Leu Ser Ile Val Val Leu Leu Cys Lys Lys Arg Ala Lys Val 
    930                 935                 940                 


Asp His Leu Asp Lys Asn Gly Gln Cys Ala Leu Val His Ala Ala Leu 
945                 950                 955                 960 


Arg Gly His Leu Glu Val Val Lys Phe Leu Ile Gln Cys Asp Trp Thr 
                965                 970                 975     


Met Ala Gly Gln Gln Gln Gly Val Phe Lys Lys Ser His Ala Ile Gln 
            980                 985                 990         


Gln Ala Leu Ile Ala Ala Ala Ser  Met Gly Tyr Thr Glu  Ile Val Ser 
        995                 1000                 1005             


Tyr Leu  Leu Asp Leu Pro Glu  Lys Asp Glu Glu Glu  Val Glu Arg 
    1010                 1015                 1020             


Ala Gln  Ile Asn Ser Phe Asp  Ser Leu Trp Gly Glu  Thr Ala Leu 
    1025                 1030                 1035             


Thr Ala  Ala Ala Gly Arg Gly  Lys Leu Glu Val Cys  Arg Leu Leu 
    1040                 1045                 1050             


Leu Glu  Gln Gly Ala Ala Val  Ala Gln Pro Asn Arg  Arg Gly Ala 
    1055                 1060                 1065             


Val Pro  Leu Phe Ser Thr Val  Arg Gln Gly His Trp  Gln Ile Val 
    1070                 1075                 1080             


Asp Leu  Leu Leu Thr His Gly  Ala Asp Val Asn Met  Ala Asp Lys 
    1085                 1090                 1095             


Gln Gly  Arg Thr Pro Leu Met  Met Ala Ala Ser Glu  Gly His Leu 
    1100                 1105                 1110             


Gly Thr  Val Asp Phe Leu Leu  Ala Gln Gly Ala Ser  Ile Ala Leu 
    1115                 1120                 1125             


Met Asp  Lys Glu Gly Leu Thr  Ala Leu Ser Trp Ala  Cys Leu Lys 
    1130                 1135                 1140             


Gly His  Leu Ser Val Val Arg  Ser Leu Val Asp Asn  Gly Ala Ala 
    1145                 1150                 1155             


Thr Asp  His Ala Asp Lys Asn  Gly Arg Thr Pro Leu  Asp Leu Ala 
    1160                 1165                 1170             


Ala Phe  Tyr Gly Asp Ala Glu  Val Val Gln Phe Leu  Val Asp His 
    1175                 1180                 1185             


Gly Ala  Met Ile Glu His Val  Asp Tyr Ser Gly Met  Arg Pro Leu 
    1190                 1195                 1200             


Asp Arg  Ala Val Gly Cys Arg  Asn Thr Ser Val Val  Val Thr Leu 
    1205                 1210                 1215             


Leu Lys  Lys Gly Ala Lys Ile  Gly Pro Ala Thr Trp  Ala Met Ala 
    1220                 1225                 1230             


Thr Ser  Lys Pro Asp Ile Met  Ile Ile Leu Leu Ser  Lys Leu Met 
    1235                 1240                 1245             


Glu Glu  Gly Asp Met Phe Tyr  Lys Lys Gly Lys Val  Lys Glu Ala 
    1250                 1255                 1260             


Ala Gln  Arg Tyr Gln Tyr Ala  Leu Lys Lys Phe Pro  Arg Glu Gly 
    1265                 1270                 1275             


Phe Gly  Glu Asp Leu Lys Thr  Phe Arg Glu Leu Lys  Val Ser Leu 
    1280                 1285                 1290             


Leu Leu  Asn Leu Ser Arg Cys  Arg Arg Lys Met Asn  Asp Phe Gly 
    1295                 1300                 1305             


Met Ala  Glu Glu Phe Ala Thr  Lys Ala Leu Glu Leu  Lys Pro Lys 
    1310                 1315                 1320             


Ser Tyr  Glu Ala Tyr Tyr Ala  Arg Ala Arg Ala Lys  Arg Ser Ser 
    1325                 1330                 1335             


Arg Gln  Phe Ala Ala Ala Leu  Glu Asp Leu Asn Glu  Ala Ile Lys 
    1340                 1345                 1350             


Leu Cys  Pro Asn Asn Arg Glu  Ile Gln Arg Leu Leu  Leu Arg Val 
    1355                 1360                 1365             


Glu Glu  Glu Cys Arg Gln Met  Gln Gln Pro Gln Gln  Pro Pro Pro 
    1370                 1375                 1380             


Pro Pro  Gln Pro Gln Gln Gln  Leu Pro Glu Glu Ala  Glu Pro Glu 
    1385                 1390                 1395             


Pro Gln  His Glu Asp Ile Tyr  Ser Val Gln Asp Ile  Phe Glu Glu 
    1400                 1405                 1410             


Glu Tyr  Leu Glu Gln Asp Val  Glu Asn Val Ser Ile  Gly Leu Gln 
    1415                 1420                 1425             


Thr Glu  Ala Arg Pro Ser Gln  Gly Leu Pro Val Ile  Gln Ser Pro 
    1430                 1435                 1440             


Pro Ser  Ser Pro Pro His Arg  Asp Ser Ala Tyr Ile  Ser Ser Ser 
    1445                 1450                 1455             


Pro Leu  Gly Ser His Gln Val  Phe Asp Phe Arg Ser  Ser Ser Ser 
    1460                 1465                 1470             


Val Gly  Ser Pro Thr Arg Gln  Thr Tyr Gln Ser Thr  Ser Pro Ala 
    1475                 1480                 1485             


Leu Ser  Pro Thr His Gln Asn  Ser His Tyr Arg Pro  Ser Pro Pro 
    1490                 1495                 1500             


His Thr  Ser Pro Ala His Gln  Gly Gly Ser Tyr Arg  Phe Ser Pro 
    1505                 1510                 1515             


Pro Pro  Val Gly Gly Gln Gly  Lys Glu Tyr Pro Ser  Pro Pro Pro 
    1520                 1525                 1530             


Ser Pro  Leu Arg Arg Gly Pro  Gln Tyr Arg Ala Ser  Pro Pro Ala 
    1535                 1540                 1545             


Glu Ser  Met Ser Val Tyr Arg  Ser Gln Ser Gly Ser  Pro Val Arg 
    1550                 1555                 1560             


Tyr Gln  Gln Glu Thr Ser Val  Ser Gln Leu Pro Gly  Arg Pro Lys 
    1565                 1570                 1575             


Ser Pro  Leu Ser Lys Met Ala  Gln Arg Pro Tyr Gln  Met Pro Gln 
    1580                 1585                 1590             


Leu Pro  Val Ala Val Pro Gln  Gln Gly Leu Arg Leu  Gln Pro Ala 
    1595                 1600                 1605             


Lys Ala  Gln Ile Val Arg Ser  Asn Gln Pro Ser Pro  Ala Val His 
    1610                 1615                 1620             


Ser Ser  Thr Val Ile Pro Thr  Gly Ala Tyr Gly Gln  Val Ala His 
    1625                 1630                 1635             


Ser Met  Ala Ser Lys Tyr Gln  Ser Ser Gln Gly Asp  Ile Gly Val 
    1640                 1645                 1650             


Ser Gln  Ser Arg Leu Val Tyr  Gln Gly Ser Ile Gly  Gly Ile Val 
    1655                 1660                 1665             


Gly Asp  Gly Arg Pro Val Gln  His Val Gln Ala Ser  Leu Ser Ala 
    1670                 1675                 1680             


Gly Ala  Ile Cys Gln His Gly  Gly Leu Thr Lys Glu  Asp Leu Pro 
    1685                 1690                 1695             


Gln Arg  Pro Ser Ser Ala Tyr  Arg Gly Gly Val Arg  Tyr Ser Gln 
    1700                 1705                 1710             


Thr Pro  Gln Ile Gly Arg Ser  Gln Ser Ala Ser Tyr  Tyr Pro Val 
    1715                 1720                 1725             


Cys His  Ser Lys Leu Asp Leu  Glu Arg Ser Ser Ser  Gln Leu Gly 
    1730                 1735                 1740             


Ser Pro  Asp Val Ser His Leu  Ile Arg Arg Pro Ile  Ser Val Asn 
    1745                 1750                 1755             


Pro Asn  Glu Ile Lys Pro His  Pro Pro Thr Pro Arg  Pro Leu Leu 
    1760                 1765                 1770             


His Ser  Gln Ser Val Gly Leu  Arg Phe Ser Pro Ser  Ser Asn Ser 
    1775                 1780                 1785             


Ile Ser  Ser Thr Ser Asn Leu  Thr Pro Thr Phe Arg  Pro Ser Ser 
    1790                 1795                 1800             


Ser Ile  Gln Gln Met Glu Ile  Pro Leu Lys Pro Ala  Tyr Glu Arg 
    1805                 1810                 1815             


Ser Cys  Asp Glu Leu Ser Pro  Val Ser Pro Thr Gln  Gly Gly Tyr 
    1820                 1825                 1830             


Pro Ser  Glu Pro Thr Arg Ser  Arg Thr Thr Pro Phe  Met Gly Ile 
    1835                 1840                 1845             


Ile Asp  Lys Thr Ala Arg Thr  Gln Gln Tyr Pro His  Leu His Gln 
    1850                 1855                 1860             


Gln Asn  Arg Thr Trp Ala Val  Ser Ser Val Asp Thr  Val Leu Ser 
    1865                 1870                 1875             


Pro Thr  Ser Pro Gly Asn Leu  Pro Gln Pro Glu Ser  Phe Ser Pro 
    1880                 1885                 1890             


Pro Ser  Ser Ile Ser Asn Ile  Ala Phe Tyr Asn Lys  Thr Asn Asn 
    1895                 1900                 1905             


Ala Gln  Asn Gly His Leu Leu  Glu Asp Asp Tyr Tyr  Ser Pro His 
    1910                 1915                 1920             


Gly Met  Leu Ala Asn Gly Ser  Arg Gly Asp Leu Leu  Glu Arg Val 
    1925                 1930                 1935             


Ser Gln  Ala Ser Ser Tyr Pro  Asp Val Lys Val Ala  Arg Thr Leu 
    1940                 1945                 1950             


Pro Val  Ala Gln Ala Tyr Gln  Asp Asn Leu Tyr Arg  Gln Leu Ser 
    1955                 1960                 1965             


Arg Asp  Ser Arg Gln Gly Gln  Thr Ser Pro Ile Lys  Pro Lys Arg 
    1970                 1975                 1980             


Pro Phe  Val Glu Ser Asn Val  
    1985                 1990 


<210>  437
<211>  3285
<212>  DNA
<213>  Homo sapiens

<400>  437
atggcagaat catccagcga atcagatcac ttccgctgtc gtgaccgatt gagtccatgg       60

gctgccagat caacgcacag gggaactcga agtcttccta cagtagaagt taccgagaag      120

gtcaacacta taacaagtac tttacaggat accagtcgga acctgcgaca agtggaccag      180

atgcttggac gataccgaga atacagtaat ggacaggcgg gtgcgataga acatttaaaa      240

gaaagcttgg aacaatcaat cgaccaactc cggagtcaac gtttattgag aaactcagga      300

gggagaagta tttctgttac aagtttgagt gcaagtgacc ttgatggtgg cactgggtca      360

gagctccatc attttccacc tacctcacct ctcaaggact atggggatcc acagggtatt      420

aaacgaatga gatcaagaac tggtgtccgg tttgttcaag agactgatga tatgactcag      480

cttcatggtt ttcatcagtc tcttcgagac ctcagcagtg aacaaattcg ccttggagat      540

gatttcaaca gggagctttc cagaaggagc cggtcagatg ccgaaacaaa aagggctttg      600

gaagaattga ctgaaaaact taatgaagcc cagaaacaag aagtggtttc agatcgggtg      660

gagcggcggc ttcaggaact ggagagagag atgcgcacag aaagggagct ggtggaaaga      720

cgccaggatc aactgggact catgtccctg cagctacagg aggcactaaa gaaacaagaa      780

gctaaagcag atgagcatga gggggcaata aaaaataagc taagacaaac tgaaactgag      840

aagaatcaac ttgaacagga attggagcta tctcgaaggt tattgaatca atcagaaggc      900

agccgagaaa cacttttgca tcaggtagaa gaactgcgta cacaacttac gaaagcagaa      960

ggtgatcgaa agggtttaca gcatcaagta tctcagattt ccaagcaaca gtcaaactat     1020

caggatgaac aaggggagga ctggagattt aggagagggg ttgagcggga aaaacaggac     1080

ctggagaagc aaatgtcaga tttgagagtg cagctgaact tcagcgcaat ggcatctgag     1140

ttagaggaag tgaaacggtg catggagaga aaagacaagg agaaagcaca tttggcatca     1200

caagtagaga atttaacacg tgaactggag aatggggaaa aacagcaact gcagatgttg     1260

gatcgactta aggagatcca gaatcacttt gacacatgtg aggccgagcg taagcatgct     1320

gaccttcaga tctcagagct gactcgccat gcggaggatg caaccaagca ggctgagcgg     1380

tacctcagtg agctccagca gtcagaggct ctgaaagagg aggcggagaa gaggagggaa     1440

gacctgaaac tgaaagctca agaatccatt aggcagtgga agcttaagca taagaagtta     1500

gaacgagcgt tggagaaaca atctgaaact gttgatgaac tgacaggcaa gaataatcag     1560

attttaaaag aaaaggatga attgaaaacc cagctgtatg cagcattaca acaaatagag     1620

aatcttcgaa aggaattgaa tgatgtccta acaaagcgtg cccttcagga ggaggagctt     1680

cactccaagg aggagaaatt acgtgatatt aagtctcatc aagctgacct tgaattggaa     1740

gttaagaatt ccctggatac catccataga ctggagagcg aattgaaaaa gcagagtaag     1800

atccaaagcc agatgaaagt tgagaaagct cacttggagg aagaaattgc agagctcaag     1860

aagagccagg cccaggacaa agctaaactt cttgagatgc aagagtccat caaggacctg     1920

agtgccatcc gagcagatct tgctaataaa ttggctgagg aagagagagc caagaaagca     1980

gtgcttaagg acctttctga cctcactgca caggcaaaat ccagggatga agaaacagct     2040

acaatcatca cacagttaaa gctggaacga gatgtgcacc agagggagct gaaagatctc     2100

acatcatcat tgcagagtgt gaaaacaaaa cacgaacaga atatccagga gcttatgaag     2160

cactttaaga aagaaaagag tgaggctgag aatcatatca ggactctgaa ggctgaaagt     2220

ttagaagaga agaatatggc taaaattcat cgtggtcagc tggagaagtt gaaatcacag     2280

tgtgacagac tgacagagga attaacccag aatgaaaatg agaacaaaaa actgaagcta     2340

aaatatcaat gtttgaagga tcaactagaa gaaagggaaa aacatataag cattgaagag     2400

gagcacttaa ggaggatgga agaggccaga ttgcagctca aggatcaact tctttgcttg     2460

gagactgaac aggaatccat tcttggtgtg ataggaaagg aaattgatgc agcttgtaaa     2520

acattctcca aggactcagt ggagaaatta aaagtttttt catctggtcc tgatatacat     2580

tatgacccac atcgctggtt agcagaaagc aagactaaac ttcagtggct ctgtgaggaa     2640

ctgaaagaga gagaaaacag agagaaaaat ctgcgacacc agctgatgct ctgcagacaa     2700

caactcagga atttgactga aaacaaggaa tctgagttgc agtgtctctt tcaacagata     2760

gaaaggcagg agcagcttct ggatgaaata catcgtgaga agagagatct actggaagag     2820

acccaaagaa aagatgaaga aatgggatct ctgcaggacc gtgtaattgc attagaaacg     2880

agtacccaag tggccttgga ccatctggag tctgtgcctg agaaactgag cctactagaa     2940

gatttcaaag acttcagaga ttcctgcagt tcatctgaga gaactgatgg aagatattcc     3000

aaatacaggg ttcgcagaaa ttctcttcag catcaccaag atgacaccaa gtacagaacc     3060

aaaagtttca aaggtgacag aacctttctg gaaggttccc acactcgtgg gttagatcac     3120

tcatcctctt ggcaggatca cagtcgcttc ctgtctagtc caagattttc atacgtgaac     3180

tcatttacca aaagaactgt tgctccagat tcagcttcaa acaaggaaga tgccacaatg     3240

aatggaacaa gttcacaacc caaaaaagag gaatatggga gctaa                     3285


<210>  438
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu Asn Leu Thr Arg Glu Leu Glu Asn Gly Glu Lys Gln Gln 
                405                 410                 415     


Leu Gln Met Leu Asp Arg Leu Lys Glu Ile Gln Asn His Phe Asp Thr 
            420                 425                 430         


Cys Glu Ala Glu Arg Lys His Ala Asp Leu Gln Ile Ser Glu Leu Thr 
        435                 440                 445             


Arg His Ala Glu Asp Ala Thr Lys Gln Ala Glu Arg Tyr Leu Ser Glu 
    450                 455                 460                 


Leu Gln Gln Ser Glu Ala Leu Lys Glu Glu Ala Glu Lys Arg Arg Glu 
465                 470                 475                 480 


Asp Leu Lys Leu Lys Ala Gln Glu Ser Ile Arg Gln Trp Lys Leu Lys 
                485                 490                 495     


His Lys Lys Leu Glu Arg Ala Leu Glu Lys Gln Ser Glu Thr Val Asp 
            500                 505                 510         


Glu Leu Thr Gly Lys Asn Asn Gln Ile Leu Lys Glu Lys Asp Glu Leu 
        515                 520                 525             


Lys Thr Gln Leu Tyr Ala Ala Leu Gln Gln Ile Glu Asn Leu Arg Lys 
    530                 535                 540                 


Glu Leu Asn Asp Val Leu Thr Lys Arg Ala Leu Gln Glu Glu Glu Leu 
545                 550                 555                 560 


His Ser Lys Glu Glu Lys Leu Arg Asp Ile Lys Ser His Gln Ala Asp 
                565                 570                 575     


Leu Glu Leu Glu Val Lys Asn Ser Leu Asp Thr Ile His Arg Leu Glu 
            580                 585                 590         


Ser Glu Leu Lys Lys Gln Ser Lys Ile Gln Ser Gln Met Lys Val Glu 
        595                 600                 605             


Lys Ala His Leu Glu Glu Glu Ile Ala Glu Leu Lys Lys Ser Gln Ala 
    610                 615                 620                 


Gln Asp Lys Ala Lys Leu Leu Glu Met Gln Glu Ser Ile Lys Asp Leu 
625                 630                 635                 640 


Ser Ala Ile Arg Ala Asp Leu Ala Asn Lys Leu Ala Glu Glu Glu Arg 
                645                 650                 655     


Ala Lys Lys Ala Val Leu Lys Asp Leu Ser Asp Leu Thr Ala Gln Ala 
            660                 665                 670         


Lys Ser Arg Asp Glu Glu Thr Ala Thr Ile Ile Thr Gln Leu Lys Leu 
        675                 680                 685             


Glu Arg Asp Val His Gln Arg Glu Leu Lys Asp Leu Thr Ser Ser Leu 
    690                 695                 700                 


Gln Ser Val Lys Thr Lys His Glu Gln Asn Ile Gln Glu Leu Met Lys 
705                 710                 715                 720 


His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg Thr Leu 
                725                 730                 735     


Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His Arg Gly 
            740                 745                 750         


Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu Glu Leu 
        755                 760                 765             


Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr Gln Cys 
    770                 775                 780                 


Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile Glu Glu 
785                 790                 795                 800 


Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys Asp Gln 
                805                 810                 815     


Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val Ile Gly 
            820                 825                 830         


Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser Val Glu 
        835                 840                 845             


Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp Pro His 
    850                 855                 860                 


Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys Glu Glu 
865                 870                 875                 880 


Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln Leu Met 
                885                 890                 895     


Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu Ser Glu 
            900                 905                 910         


Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu Leu Asp 
        915                 920                 925             


Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln Arg Lys 
    930                 935                 940                 


Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu Glu Thr 
945                 950                 955                 960 


Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Pro Glu Lys Leu 
                965                 970                 975     


Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Asp Ser Cys Ser Ser Ser 
            980                 985                 990         


Glu Arg Thr Asp Gly Arg Tyr Ser  Lys Tyr Arg Val Arg  Arg Asn Ser 
        995                 1000                 1005             


Leu Gln  His His Gln Asp Asp  Thr Lys Tyr Arg Thr  Lys Ser Phe 
    1010                 1015                 1020             


Lys Gly  Asp Arg Thr Phe Leu  Glu Gly Ser His Thr  Arg Gly Leu 
    1025                 1030                 1035             


Asp His  Ser Ser Ser Trp Gln  Asp His Ser Arg Phe  Leu Ser Ser 
    1040                 1045                 1050             


Pro Arg  Phe Ser Tyr Val Asn  Ser Phe Thr Lys Arg  Thr Val Ala 
    1055                 1060                 1065             


Pro Asp  Ser Ala Ser Asn Lys  Glu Asp Ala Thr Met  Asn Gly Thr 
    1070                 1075                 1080             


Ser Ser  Gln Pro Lys Lys Glu  Glu Tyr Gly Ser 
    1085                 1090                 


<210>  439
<211>  2547
<212>  DNA
<213>  Homo sapiens

<400>  439
atggagggaa gcccatccct gagacgcatg acagtgatgc gggagaaggg ccggcgccag       60

gctgtcaggg gcccggcctt catgttcaat gaccgcggca ccagcctcac cgccgaggag      120

gagcgcttcc tcgacgccgc cgagtacggc aacatcccag tggtgcgcaa gatgctggag      180

gagtccaaga cgctgaacgt caactgcgtg gactacatgg gccagaacgc gctgcagctg      240

gctgtgggca acgagcacct ggaggtgacc gagctgctgc tcaagaagga gaacctggcg      300

cgcattggcg acgccctgct gctcgccatc agcaagggct acgtgcgcat cgtagaggcc      360

atcctcaacc accctggctt cgcggccagc aagcgtctca ctctgagccc ctgtgagcag      420

gagctgcagg acgacgactt ctacgcttac gacgaggacg gcacgcgctt ctcgccggac      480

atcaccccca tcatcctggc ggcgcactgc cagaaatacg aagtggtgca catgctgctg      540

atgaagggtg ccaggatcga gcggccgcac gactatttct gcaagtgcgg ggactgcatg      600

gagaagcaga ggcacgactc cttcagccac tcacgctcga ggatcaatgc ctacaagggg      660

ctggccagcc cggcttacct ctcattgtcc agcgaggacc cggtgcttac ggccctagag      720

ctcagcaacg agctggccaa gctggccaac atagagaagg agttcaagaa tgactatcgg      780

aagctctcca tgcaatgcaa agactttgta gtgggtgtgc tggatctctg ccgagactca      840

gaagaggtag aagccattct gaatggagat ctggaatcag cagagcctct ggaggtacac      900

aggcacaaag cttcattaag tcgtgtcaaa cttgccatta agtatgaagt caaaaagttt      960

gtggctcatc ccaactgcca gcagcagctc ttgacgatct ggtatgagaa cctctcaggc     1020

ctaagggagc agaccatagc tatcaagtgt ctcgttgtgc tggtcgtggc cctgggcctt     1080

ccattcctgg ccattggcta ctggatcgca ccttgcagca ggctggggaa aattctgcga     1140

agccctttta tgaagtttgt agcacatgca gcttctttca tcatcttcct gggtctgctt     1200

gtgttcaatg cctcagacag gttcgaaggc atcaccacgc tgcccaatat cacagttact     1260

gactatccca aacagatctt cagggtgaaa accacccagt ttacatggac tgaaatgcta     1320

attatggtct gggttcttgg aatgatgtgg tctgaatgta aagagctctg gctggaagga     1380

cctagggaat acattttgca gttgtggaat gtgcttgact ttgggatgct gtccatcttc     1440

attgctgctt tcacagccag attcctagct ttccttcagg caacgaaggc acaacagtat     1500

gtggacagtt acgtccaaga gagtgacctc agtgaagtga cactcccacc agagatacag     1560

tatttcactt atgctagaga taaatggctc ccttctgacc ctcagattat atctgaaggc     1620

ctttatgcca tagctgttgt gctcagcttc tctcggattg cgtacatcct ccctgcaaat     1680

gagagctttg gccccctgca gatctctctt ggaaggactg taaaggacat attcaagttc     1740

atggtcctct ttattatggt gttttttgcc tttatgattg gcatgttcat actttattct     1800

tactaccttg gggctaaagt taatgctgct tttaccactg tagaagaaag tttcaagact     1860

ttattttggt caatatttgg gttgtctgaa gtgacttccg ttgtgctcaa atatgatcac     1920

aaattcatag aaaatattgg atacgttctt tatggaatat acaatgtaac tatggtggtc     1980

gttttactca acatgctaat tgctatgatt aatagctcat atcaagaaat tgaggatgac     2040

agtgatgtag aatggaagtt tgctcgttca aaactttggt tatcctattt tgatgatgga     2100

aaaacattac ctccaccttt cagtctagtt cctagtccaa aatcatttgt ttatttcatc     2160

atgcgaattg ttaactttcc caaatgcaga aggagaaggc ttcagaagga tatagaaatg     2220

ggaatgggta actcaaagtc caggttaaac ctcttcactc agtctaactc aagagttttt     2280

gaatcacaca gttttaacag cattctcaat cagccaacac gttatcagca gataatgaaa     2340

agacttataa agcggtatgt tttgaaagca caagtagaca aagaaaatga tgaagttaat     2400

gaaggtgaat taaaagaaat caagcaagat atctccagcc ttcgttatga acttttggaa     2460

gacaagagcc aagcaactga ggaattagcc attctaattc ataaacttag tgagaaactg     2520

aatcccagca tgctgagatg tgaatga                                         2547


<210>  440
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      


Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          


Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              


Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  


Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  


Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      


Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         


Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             


Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 


Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 


Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     


His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         


Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             


Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 


Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 


Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     


Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         


Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             


Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 


Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 


Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     


Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         


Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             


Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 


Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 


Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     


Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         


Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             


Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 


Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 


Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     


Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         


Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             


Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 


Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 


Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     


Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         


Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             


Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 


Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 


Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     


Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         


Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             


Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 


Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 


Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     


Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe 
            740                 745                 750         


Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile 
        755                 760                 765             


Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys 
    770                 775                 780                 


Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn 
785                 790                 795                 800 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                805                 810                 815     


Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu 
            820                 825                 830         


Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        835                 840                 845             


<210>  441
<211>  2343
<212>  DNA
<213>  Homo sapiens

<400>  441
atggacgagc aggcgggtcc cggcgtcttc ttcagcaaca accacccggg cgccggcggt       60

gccaaggggc tcgggcctct ggcggaggct gccgcggccg gcgacggggc ggctgcggcg      120

ggggcggccc gagcccagta cagtctcccg gggatcctgc acttcctgca gcacgagtgg      180

gcccgcttcg aggtggagag agcccagtgg gaggtggagc gggcggagct gcaggcccag      240

attgccttcc tgcagggaga aaggaagggc caagaaaatt tgaagaagga tcttgtgagg      300

aggatcaaaa tgttggagta tgctcttaaa caggaaagag ccaaatacca caagttgaaa      360

tacgggacag aattgaatca gggagatatg aagcctccaa gctatgattc tgatgaaggt      420

aatgaaacag aagtgcagcc acaacaaaac agccagttaa tgtggaaaca aggtcgacaa      480

ctactcagac agtatctaca ggaggtgggt tatacagata ctattctaga tgtgaaatct      540

aaacgagtgc gagctttgtt gggcttttca agtgatgtca cggacaggga agatgacaaa      600

aatcaggact cagttgtaaa tggcacagag gctgaagtta aagagacagc aatgattgca      660

aaatctgagt taacagattc tgcctccgtg ctggataatt tcaaattcct tgaaagtgca      720

gctgcagatt tcagtgatga agatgaagat gatgatgttg atggaagaga gaaaagcgtc      780

attgatactt caacaattgt taggaaaaaa gcattgcctg acagcggtga agatcgagat      840

acaaaagaag ctctaaagga gtttgacttc ttggttacat cagaggaagg agacaatgaa      900

tctagaagtg caggcgatgg aacagactgg gaaaaggaag accagtgtct catgcctgaa      960

gcctggaatg tggaccaggg agtaattacc aaactcaagg aacaatacaa aaaggagaga     1020

aaggggaaaa agggggtgaa gaggcccaat aggtcaaaac tacaagatat gcttgctaat     1080

ttgagagatg ttgatgaact tccttcattg cagccatctg tgggttcacc ttccagaccc     1140

agcagctcca ggcttcctga acatgaaatt aatagggcag atgaagtgga agcattgaca     1200

tttcctcctt cttctggaaa gtcattcatc atgggagcag atgaagccct tgaaagtgaa     1260

ctgggacttg gagaactagc aggccttacg gtggccaatg aagcagactc actaacttat     1320

gatatagcaa acaataaaga tgcattgagg aagacatgga accctaagtt tacattgaga     1380

agtcactttg atggcatccg agcccttgct ttccatccca ttgagcctgt tttgataaca     1440

gcatcagagg atcacacatt aaaaatgtgg aatttacaga aaacagcccc agccaaaaag     1500

agcacttctc ttgatgtaga acctatctat acattcagag cccataaagg tccagtgctt     1560

tgtgtggtaa tgagcagcaa tggtgagcag tgttacagtg gtggtactga tggactgatc     1620

cagggctgga ataccactaa tcccaacatc gacccctatg attcttatga tccttctgtt     1680

ttacgaggcc ctctgctagg ccacacggat gcagtctggg gtttggctta tagtgcagca     1740

catcagcgtt tgttgtcctg ttcagcagat ggcactctgc gtttatggaa tacaactgag     1800

gttgctccag cactaagtgt atttaatgat actaaagaac tgggaatccc tgcctctgtg     1860

gatctagtga gcagtgaccc gagccatatg gtagcatcat tcagcaaggg atatacaagc     1920

atttttaaca tggaaacaca acaacgcatt ctcactttag aatccaatgt agatacaaca     1980

gccaactctt cctgccaaat aaatagagtc atcagtcatc ctactcttcc gatcagcatc     2040

actgctcatg aagacaggca catcaaattc tatgataaca atacaggcaa actgatccac     2100

tcgatggtag cccacctaga agctgttaca agtttagcag ttgatcccaa tggcctttac     2160

ttgatgtctg gcagtcatga ctgttcaata cgtttatgga atctagaaag taagacgtgt     2220

atccaagaat tcacagctca tcgaaaaaag tttgaagaat cgattcatga tgtagctttc     2280

cacccatcca aatgctatat agccagtgct ggagctgacg cactggctaa agtctttgta     2340

tga                                                                   2343


<210>  442
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Asp Glu Gln Ala Gly Pro Gly Val Phe Phe Ser Asn Asn His Pro 
1               5                   10                  15      


Gly Ala Gly Gly Ala Lys Gly Leu Gly Pro Leu Ala Glu Ala Ala Ala 
            20                  25                  30          


Ala Gly Asp Gly Ala Ala Ala Ala Gly Ala Ala Arg Ala Gln Tyr Ser 
        35                  40                  45              


Leu Pro Gly Ile Leu His Phe Leu Gln His Glu Trp Ala Arg Phe Glu 
    50                  55                  60                  


Val Glu Arg Ala Gln Trp Glu Val Glu Arg Ala Glu Leu Gln Ala Gln 
65                  70                  75                  80  


Ile Ala Phe Leu Gln Gly Glu Arg Lys Gly Gln Glu Asn Leu Lys Lys 
                85                  90                  95      


Asp Leu Val Arg Arg Ile Lys Met Leu Glu Tyr Ala Leu Lys Gln Glu 
            100                 105                 110         


Arg Ala Lys Tyr His Lys Leu Lys Tyr Gly Thr Glu Leu Asn Gln Gly 
        115                 120                 125             


Asp Met Lys Pro Pro Ser Tyr Asp Ser Asp Glu Gly Asn Glu Thr Glu 
    130                 135                 140                 


Val Gln Pro Gln Gln Asn Ser Gln Leu Met Trp Lys Gln Gly Arg Gln 
145                 150                 155                 160 


Leu Leu Arg Gln Tyr Leu Gln Glu Val Gly Tyr Thr Asp Thr Ile Leu 
                165                 170                 175     


Asp Val Lys Ser Lys Arg Val Arg Ala Leu Leu Gly Phe Ser Ser Asp 
            180                 185                 190         


Val Thr Asp Arg Glu Asp Asp Lys Asn Gln Asp Ser Val Val Asn Gly 
        195                 200                 205             


Thr Glu Ala Glu Val Lys Glu Thr Ala Met Ile Ala Lys Ser Glu Leu 
    210                 215                 220                 


Thr Asp Ser Ala Ser Val Leu Asp Asn Phe Lys Phe Leu Glu Ser Ala 
225                 230                 235                 240 


Ala Ala Asp Phe Ser Asp Glu Asp Glu Asp Asp Asp Val Asp Gly Arg 
                245                 250                 255     


Glu Lys Ser Val Ile Asp Thr Ser Thr Ile Val Arg Lys Lys Ala Leu 
            260                 265                 270         


Pro Asp Ser Gly Glu Asp Arg Asp Thr Lys Glu Ala Leu Lys Glu Phe 
        275                 280                 285             


Asp Phe Leu Val Thr Ser Glu Glu Gly Asp Asn Glu Ser Arg Ser Ala 
    290                 295                 300                 


Gly Asp Gly Thr Asp Trp Glu Lys Glu Asp Gln Cys Leu Met Pro Glu 
305                 310                 315                 320 


Ala Trp Asn Val Asp Gln Gly Val Ile Thr Lys Leu Lys Glu Gln Tyr 
                325                 330                 335     


Lys Lys Glu Arg Lys Gly Lys Lys Gly Val Lys Arg Pro Asn Arg Ser 
            340                 345                 350         


Lys Leu Gln Asp Met Leu Ala Asn Leu Arg Asp Val Asp Glu Leu Pro 
        355                 360                 365             


Ser Leu Gln Pro Ser Val Gly Ser Pro Ser Arg Pro Ser Ser Ser Arg 
    370                 375                 380                 


Leu Pro Glu His Glu Ile Asn Arg Ala Asp Glu Val Glu Ala Leu Thr 
385                 390                 395                 400 


Phe Pro Pro Ser Ser Gly Lys Ser Phe Ile Met Gly Ala Asp Glu Ala 
                405                 410                 415     


Leu Glu Ser Glu Leu Gly Leu Gly Glu Leu Ala Gly Leu Thr Val Ala 
            420                 425                 430         


Asn Glu Ala Asp Ser Leu Thr Tyr Asp Ile Ala Asn Asn Lys Asp Ala 
        435                 440                 445             


Leu Arg Lys Thr Trp Asn Pro Lys Phe Thr Leu Arg Ser His Phe Asp 
    450                 455                 460                 


Gly Ile Arg Ala Leu Ala Phe His Pro Ile Glu Pro Val Leu Ile Thr 
465                 470                 475                 480 


Ala Ser Glu Asp His Thr Leu Lys Met Trp Asn Leu Gln Lys Thr Ala 
                485                 490                 495     


Pro Ala Lys Lys Ser Thr Ser Leu Asp Val Glu Pro Ile Tyr Thr Phe 
            500                 505                 510         


Arg Ala His Lys Gly Pro Val Leu Cys Val Val Met Ser Ser Asn Gly 
        515                 520                 525             


Glu Gln Cys Tyr Ser Gly Gly Thr Asp Gly Leu Ile Gln Gly Trp Asn 
    530                 535                 540                 


Thr Thr Asn Pro Asn Ile Asp Pro Tyr Asp Ser Tyr Asp Pro Ser Val 
545                 550                 555                 560 


Leu Arg Gly Pro Leu Leu Gly His Thr Asp Ala Val Trp Gly Leu Ala 
                565                 570                 575     


Tyr Ser Ala Ala His Gln Arg Leu Leu Ser Cys Ser Ala Asp Gly Thr 
            580                 585                 590         


Leu Arg Leu Trp Asn Thr Thr Glu Val Ala Pro Ala Leu Ser Val Phe 
        595                 600                 605             


Asn Asp Thr Lys Glu Leu Gly Ile Pro Ala Ser Val Asp Leu Val Ser 
    610                 615                 620                 


Ser Asp Pro Ser His Met Val Ala Ser Phe Ser Lys Gly Tyr Thr Ser 
625                 630                 635                 640 


Ile Phe Asn Met Glu Thr Gln Gln Arg Ile Leu Thr Leu Glu Ser Asn 
                645                 650                 655     


Val Asp Thr Thr Ala Asn Ser Ser Cys Gln Ile Asn Arg Val Ile Ser 
            660                 665                 670         


His Pro Thr Leu Pro Ile Ser Ile Thr Ala His Glu Asp Arg His Ile 
        675                 680                 685             


Lys Phe Tyr Asp Asn Asn Thr Gly Lys Leu Ile His Ser Met Val Ala 
    690                 695                 700                 


His Leu Glu Ala Val Thr Ser Leu Ala Val Asp Pro Asn Gly Leu Tyr 
705                 710                 715                 720 


Leu Met Ser Gly Ser His Asp Cys Ser Ile Arg Leu Trp Asn Leu Glu 
                725                 730                 735     


Ser Lys Thr Cys Ile Gln Glu Phe Thr Ala His Arg Lys Lys Phe Glu 
            740                 745                 750         


Glu Ser Ile His Asp Val Ala Phe His Pro Ser Lys Cys Tyr Ile Ala 
        755                 760                 765             


Ser Ala Gly Ala Asp Ala Leu Ala Lys Val Phe Val 
    770                 775                 780 


<210>  443
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  443
atgccattcg gtaacaccca caacaagttc aagctgaatt acaagcctga ggaggagtac       60

cccgacctca gcaaacataa caaccacatg gccaaggtac tgacccttga actctacaag      120

aagctgcggg acaaggagac tccatctggc ttcactgtag acgatgtcat ccagacagga      180

gtggacaacc caggtcaccc cttcatcatg accgtgggct gcgtggctgg tgatgaggag      240

tcctacgaag ttttcaagga actctttgac cccatcatct cggatcgcca cgggggctac      300

aaacccactg acaagcacaa gactgacctc aaccatgaaa acctcaaggg tggagacgac      360

ctggacccta actacgtgct cagcagccgc gtccgcactg gccgcagcat caagggctac      420

acgttgcccc cacactgctc ccgtggcgag cgccgggcgg tggagaagct ctctgtggaa      480

gctctcaaca gcctgacggg cgagttcaaa gggaagtact accctctgaa gagcatgacg      540

gagaaggagc agcagcagct catcgatgac cacttcctgt tcgacaagcc cgtgtccccg      600

ctgctgctgg cctcaggcat ggcccgcgac tggcccgacg cccgtggcat ctggcacaat      660

gacaacaaga gcttcctggt gtgggtgaac gaggaggatc acctccgggt catctccatg      720

gagaaggggg gcaacatgaa ggaggttttc cgccgcttct gcgtagggct gcagaagatt      780

gaggagatct ttaagaaagc tggccacccc ttcatgtgga accagcacct gggctacgtg      840

ctcacctgcc catccaacct gggcactggg ctgcgtggag gcgtgcatgt gaagctggcg      900

cacctgagca agcaccccaa gttcgaggag atcctcaccc gcctgcgtct gcagaagagg      960

ggtacaggtg gcgtggacac agctgccgtg ggctcagtat ttgacgtgtc caacgctgat     1020

cggctgggct cgtccgaagt agaacaggtg cagctggtgg tggatggtgt gaagctcatg     1080

gtggaaatgg agaagaagtt ggagaaaggc cagtccattg acgacatgat ccccgcccag     1140

aagtag                                                                1146


<210>  444
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro 
1               5                   10                  15      


Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His 
            100                 105                 110         


Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu 
145                 150                 155                 160 


Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly 
                245                 250                 255     


Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met 
            260                 265                 270         


Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys 
    290                 295                 300                 


His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu 
        355                 360                 365             


Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys 
    370                 375                 380     


<210>  445
<211>  240
<212>  DNA
<213>  Homo sapiens

<400>  445
atgagtgaat tttggcacaa actgggctgc tgtgtggtag agaaacccca gccgaagaag       60

aagagaagac ggattgaccg gaccatgatt ggggaaccaa tgaattttgt tcacctgact      120

cacattggct caggggagat gggggccgga gatggacttg ccatgacagg tgcagttcag      180

gagcagatga gatccaaggg aaaccgagat aggccatgga gcaattctag gggcttatag      240


<210>  446
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Ser Glu Phe Trp His Lys Leu Gly Cys Cys Val Val Glu Lys Pro 
1               5                   10                  15      


Gln Pro Lys Lys Lys Arg Arg Arg Ile Asp Arg Thr Met Ile Gly Glu 
            20                  25                  30          


Pro Met Asn Phe Val His Leu Thr His Ile Gly Ser Gly Glu Met Gly 
        35                  40                  45              


Ala Gly Asp Gly Leu Ala Met Thr Gly Ala Val Gln Glu Gln Met Arg 
    50                  55                  60                  


Ser Lys Gly Asn Arg Asp Arg Pro Trp Ser Asn Ser Arg Gly Leu 
65                  70                  75                  


<210>  447
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  447
atggaggagg aggcgagccg cagcgccgcg gcgacgaacc cagggagtcg gcttacccgc       60

tggccgcctc ctgacaagcg ggagggatcc gcggtggacc cagggaagcg gaggagcctg      120

gcggccaccc cctcttcctc acttccctgt actctcatcg ctctcggcct ccgacacgaa      180

aaggaagcaa atgagctgat ggaagatctg tttgaaactt tccaagatga gatgggattc      240

tccaacatgg aagatgatgg cccagaagag gaggagcgtg tggctgagcc tcaagctaac      300

tttaacaccc ctcaagctct acggtttgag gaactactgg ccaacctact aaatgaacaa      360

catcagatag cgaaggaact atttgaacag ctgaagatga agaaaccttc agccaaacag      420

cagaaggagg tagagaaggt taaaccccag tgtaaggaag ttcatcagac cctgattctg      480

gacccagcac aaaggaagag actccagcag cagatgcagc agcatgttca gctcttgaca      540

caaatccacc ttcttgccac ctgcaacccc aatctcaatc cggaggccag tagcaccagg      600

atatgtctta aagagctggg aacctttgct caaagctcca tcgcccttca ccatcagtac      660

aaccccaagt ttcagaccct gttccaaccc tgtaacttga tgggagctat gcagctgatt      720

gaagacttca gcacacatgt cagcattgac tgcagccctc ataaaactgt caagaagact      780

gccaatgaat ttccctgttt gccaaagcaa gtggcttgga tcctggccac aagcaaggtt      840

ttcatgtatc cagagttact tccagtgtgt tccctgaagg caaagaatcc ccaggataag      900

atcctcttca ccaaggctga ggacaacaag taccttctaa cctgcaagac tgcccgccaa      960

ctgacagtga gaatcaagaa cctcaacatg aacagagctc ctgacaacat cattaaattt     1020

tataagaaga ccaaacagct gccagtccta ggaaaatgct gtgaagagat ccagccacat     1080

cagtggaagc cacctataga gagagaagaa caccggctcc cattctggtt aaaggccagt     1140

ctgccatcca tccaggaaga actgcggcac atggctgatg gtgctagaga ggtaggaaat     1200

atgactggaa ccactgagat caactcagat caaggcctag aaaaagacaa ctcagagttg     1260

gggagtgaaa ctcggtaccc actgctattg cctaagggtg tagtcctgaa actgaagcca     1320

gttgccgacc gtttccccaa gaaggcttgg agacagaagc gttcatcagt cctgaaaccc     1380

ctccttatcc aacccagccc ctctctccag cccagcttca accctgggaa aacaccagcc     1440

caatcaactc attcagaagc ccctccgagc aaaatggtgc tccggattcc tcacccaata     1500

cagccagcca ctgttttaca gacagttcca ggtgtccctc cactgggggt cagtggaggt     1560

gagagttttg agtctcctgc agcactgcct gctatgcccc ctgaggccag gacaagcttc     1620

cctctgtctg agtcccagac tttgctctct tctgcccctg tgcccaaggt aatgatgccc     1680

tcccctgcct cttccatgtt tcgaaagcca tatgtgagac ggagaccctc aaaaagaagg     1740

ggagccaggg cctttcgctg tatcaaacct gcccctgtta tccaccctgc atctgttatc     1800

ttcactgttc ctgctaccac tgtgaagatt gtgagccttg gcggtggctg taacatgatc     1860

cagcctgtca atgcggctgt ggcccagagt ccccagacta ttcccatcgc caccctcttg     1920

gttaacccta cttccttccc ctgtccattg aaccagcccc ttgtggcctc ctctgtctca     1980

cccttaattg tttctggcaa ttctgtgaat cttcctatac catccacccc tgaagataag     2040

gcccacatga atgtggacat tgcttgtgct gtggctgatg gggaaaatgc ctttcagggc     2100

ctagaaccca aattagagcc ccaggaacta tctcctctct ctgctactgt tttccccaaa     2160

gtggaacata gcccagggcc tccaccagtc gataaacagt gccaagaagg attgtcagag     2220

aacagtgcct atcgctggac cgttgtgaaa acagaggagg gaaggcaagc tctggagccg     2280

ctccctcagg gcatccagga gtctctaaac aactcttccc ctggggattt agaggaagtt     2340

gtcaagatgg aacctgaaga tgctacagag gaaatcagtg gatttctttg a              2391


<210>  448
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Glu Glu Glu Ala Ser Arg Ser Ala Ala Ala Thr Asn Pro Gly Ser 
1               5                   10                  15      


Arg Leu Thr Arg Trp Pro Pro Pro Asp Lys Arg Glu Gly Ser Ala Val 
            20                  25                  30          


Asp Pro Gly Lys Arg Arg Ser Leu Ala Ala Thr Pro Ser Ser Ser Leu 
        35                  40                  45              


Pro Cys Thr Leu Ile Ala Leu Gly Leu Arg His Glu Lys Glu Ala Asn 
    50                  55                  60                  


Glu Leu Met Glu Asp Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe 
65                  70                  75                  80  


Ser Asn Met Glu Asp Asp Gly Pro Glu Glu Glu Glu Arg Val Ala Glu 
                85                  90                  95      


Pro Gln Ala Asn Phe Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Leu 
            100                 105                 110         


Leu Ala Asn Leu Leu Asn Glu Gln His Gln Ile Ala Lys Glu Leu Phe 
        115                 120                 125             


Glu Gln Leu Lys Met Lys Lys Pro Ser Ala Lys Gln Gln Lys Glu Val 
    130                 135                 140                 


Glu Lys Val Lys Pro Gln Cys Lys Glu Val His Gln Thr Leu Ile Leu 
145                 150                 155                 160 


Asp Pro Ala Gln Arg Lys Arg Leu Gln Gln Gln Met Gln Gln His Val 
                165                 170                 175     


Gln Leu Leu Thr Gln Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu 
            180                 185                 190         


Asn Pro Glu Ala Ser Ser Thr Arg Ile Cys Leu Lys Glu Leu Gly Thr 
        195                 200                 205             


Phe Ala Gln Ser Ser Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe 
    210                 215                 220                 


Gln Thr Leu Phe Gln Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile 
225                 230                 235                 240 


Glu Asp Phe Ser Thr His Val Ser Ile Asp Cys Ser Pro His Lys Thr 
                245                 250                 255     


Val Lys Lys Thr Ala Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala 
            260                 265                 270         


Trp Ile Leu Ala Thr Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro 
        275                 280                 285             


Val Cys Ser Leu Lys Ala Lys Asn Pro Gln Asp Lys Ile Leu Phe Thr 
    290                 295                 300                 


Lys Ala Glu Asp Asn Lys Tyr Leu Leu Thr Cys Lys Thr Ala Arg Gln 
305                 310                 315                 320 


Leu Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn 
                325                 330                 335     


Ile Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys 
            340                 345                 350         


Cys Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg 
        355                 360                 365             


Glu Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro Ser Ile 
    370                 375                 380                 


Gln Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val Gly Asn 
385                 390                 395                 400 


Met Thr Gly Thr Thr Glu Ile Asn Ser Asp Gln Gly Leu Glu Lys Asp 
                405                 410                 415     


Asn Ser Glu Leu Gly Ser Glu Thr Arg Tyr Pro Leu Leu Leu Pro Lys 
            420                 425                 430         


Gly Val Val Leu Lys Leu Lys Pro Val Ala Asp Arg Phe Pro Lys Lys 
        435                 440                 445             


Ala Trp Arg Gln Lys Arg Ser Ser Val Leu Lys Pro Leu Leu Ile Gln 
    450                 455                 460                 


Pro Ser Pro Ser Leu Gln Pro Ser Phe Asn Pro Gly Lys Thr Pro Ala 
465                 470                 475                 480 


Gln Ser Thr His Ser Glu Ala Pro Pro Ser Lys Met Val Leu Arg Ile 
                485                 490                 495     


Pro His Pro Ile Gln Pro Ala Thr Val Leu Gln Thr Val Pro Gly Val 
            500                 505                 510         


Pro Pro Leu Gly Val Ser Gly Gly Glu Ser Phe Glu Ser Pro Ala Ala 
        515                 520                 525             


Leu Pro Ala Met Pro Pro Glu Ala Arg Thr Ser Phe Pro Leu Ser Glu 
    530                 535                 540                 


Ser Gln Thr Leu Leu Ser Ser Ala Pro Val Pro Lys Val Met Met Pro 
545                 550                 555                 560 


Ser Pro Ala Ser Ser Met Phe Arg Lys Pro Tyr Val Arg Arg Arg Pro 
                565                 570                 575     


Ser Lys Arg Arg Gly Ala Arg Ala Phe Arg Cys Ile Lys Pro Ala Pro 
            580                 585                 590         


Val Ile His Pro Ala Ser Val Ile Phe Thr Val Pro Ala Thr Thr Val 
        595                 600                 605             


Lys Ile Val Ser Leu Gly Gly Gly Cys Asn Met Ile Gln Pro Val Asn 
    610                 615                 620                 


Ala Ala Val Ala Gln Ser Pro Gln Thr Ile Pro Ile Ala Thr Leu Leu 
625                 630                 635                 640 


Val Asn Pro Thr Ser Phe Pro Cys Pro Leu Asn Gln Pro Leu Val Ala 
                645                 650                 655     


Ser Ser Val Ser Pro Leu Ile Val Ser Gly Asn Ser Val Asn Leu Pro 
            660                 665                 670         


Ile Pro Ser Thr Pro Glu Asp Lys Ala His Met Asn Val Asp Ile Ala 
        675                 680                 685             


Cys Ala Val Ala Asp Gly Glu Asn Ala Phe Gln Gly Leu Glu Pro Lys 
    690                 695                 700                 


Leu Glu Pro Gln Glu Leu Ser Pro Leu Ser Ala Thr Val Phe Pro Lys 
705                 710                 715                 720 


Val Glu His Ser Pro Gly Pro Pro Pro Val Asp Lys Gln Cys Gln Glu 
                725                 730                 735     


Gly Leu Ser Glu Asn Ser Ala Tyr Arg Trp Thr Val Val Lys Thr Glu 
            740                 745                 750         


Glu Gly Arg Gln Ala Leu Glu Pro Leu Pro Gln Gly Ile Gln Glu Ser 
        755                 760                 765             


Leu Asn Asn Ser Ser Pro Gly Asp Leu Glu Glu Val Val Lys Met Glu 
    770                 775                 780                 


Pro Glu Asp Ala Thr Glu Glu Ile Ser Gly Phe Leu 
785                 790                 795     


<210>  449
<211>  1983
<212>  DNA
<213>  Homo sapiens

<400>  449
atggaggcgc taatggcccg gggcgcgctc acgggtcccc tgagggcgct ctgtctcctg       60

ggctgcctgc tgagccacgc cgccgccgcg ccgtcgccca tcatcaagtt ccccggcgat      120

gtcgccccca aaacggacaa agagttggca gtgcaatacc tgaacacctt ctatggctgc      180

cccaaggaga gctgcaacct gtttgtgctg aaggacacac taaagaagat gcagaagttc      240

tttggactgc cccagacagg tgatcttgac cagaatacca tcgagaccat gcggaagcca      300

cgctgcggca acccagatgt ggccaactac aacttcttcc ctcgcaagcc caagtgggac      360

aagaaccaga tcacatacag gatcattggc tacacacctg atctggaccc agagacagtg      420

gatgatgcct ttgctcgtgc cttccaagtc tggagcgatg tgaccccact gcggttttct      480

cgaatccatg atggagaggc agacatcatg atcaactttg gccgctggga gcatggcgat      540

ggatacccct ttgacggtaa ggacggactc ctggctcatg ccttcgcccc aggcactggt      600

gttgggggag actcccattt tgatgacgat gagctatgga ccttgggaga aggccaagtg      660

gtccgtgtga agtatgggaa cgccgatggg gagtactgca agttcccctt cttgttcaat      720

ggcaaggagt acaacagctg cactgatacc ggccgcagcg atggcttcct ctggtgctcc      780

accacctaca actttgagaa ggatggcaag tacggcttct gtccccatga agccctgttc      840

accatgggcg gcaacgctga aggacagccc tgcaagtttc cattccgctt ccagggcaca      900

tcctatgaca gctgcaccac tgagggccgc acggatggct accgctggtg cggcaccact      960

gaggactacg accgcgacaa gaagtatggc ttctgccctg agaccgccat gtccactgtt     1020

ggtgggaact cagaaggtgc cccctgtgtc ttccccttca ctttcctggg caacaaatat     1080

gagagctgca ccagcgccgg ccgcagtgac ggaaagatgt ggtgtgcgac cacagccaac     1140

tacgatgatg accgcaagtg gggcttctgc cctgaccaag ggtacagcct gttcctcgtg     1200

gcagcccacg agtttggcca cgccatgggg ctggagcact cccaagaccc tggggccctg     1260

atggcaccca tttacaccta caccaagaac ttccgtctgt cccaggatga catcaagggc     1320

attcaggagc tctatggggc ctctcctgac attgaccttg gcaccggccc cacccccacg     1380

ctgggccctg tcactcctga gatctgcaaa caggacattg tatttgatgg catcgctcag     1440

atccgtggtg agatcttctt cttcaaggac cggttcattt ggcggactgt gacgccacgt     1500

gacaagccca tggggcccct gctggtggcc acattctggc ctgagctccc ggaaaagatt     1560

gatgcggtat acgaggcccc acaggaggag aaggctgtgt tctttgcagg gaatgaatac     1620

tggatctact cagccagcac cctggagcga gggtacccca agccactgac cagcctggga     1680

ctgccccctg atgtccagcg agtggatgcc gcctttaact ggagcaaaaa caagaagaca     1740

tacatctttg ctggagacaa attctggaga tacaatgagg tgaagaagaa aatggatcct     1800

ggcttcccca agctcatcgc agatgcctgg aatgccatcc ccgataacct ggatgccgtc     1860

gtggacctgc agggcggcgg tcacagctac ttcttcaagg gtgcctatta cctgaagctg     1920

gagaaccaaa gtctgaagag cgtgaagttt ggaagcatca aatccgactg gctaggctgc     1980

tga                                                                   1983


<210>  450
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
            20                  25                  30          


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
        35                  40                  45              


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
    50                  55                  60                  


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
65                  70                  75                  80  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                85                  90                  95      


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
            100                 105                 110         


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        115                 120                 125             


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    130                 135                 140                 


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
145                 150                 155                 160 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                165                 170                 175     


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            180                 185                 190         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        195                 200                 205             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    210                 215                 220                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                245                 250                 255     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            260                 265                 270         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        275                 280                 285             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
305                 310                 315                 320 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                325                 330                 335     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            340                 345                 350         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        355                 360                 365             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    370                 375                 380                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
385                 390                 395                 400 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                405                 410                 415     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            420                 425                 430         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        435                 440                 445             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    450                 455                 460                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
465                 470                 475                 480 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                485                 490                 495     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            500                 505                 510         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        515                 520                 525             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    530                 535                 540                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                565                 570                 575     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            580                 585                 590         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        595                 600                 605             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    610                 615                 620                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
625                 630                 635                 640 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                645                 650                 655     


Trp Leu Gly Cys 
            660 


<210>  451
<211>  2430
<212>  DNA
<213>  Homo sapiens

<400>  451
atgtttaaat cgctgacaaa agtcaacaag gtgaagccta taggagagaa caatgagaat       60

gaacaaagtt ctcgtcggaa tgaagaaggc tctcacccaa gtaatcagtc tcagcaaacc      120

acagcacagg aagaaaacaa aggtgaagag aaatctctca aaaccaagtc aactccagtc      180

acgtctgaag agccacacac caacatacaa gacaaactct ccaagaaaaa ttcctctgga      240

gatctgacca caaaccctga ccctcaaaat gcagcagaac caactggaac agtgccagag      300

cagaaggaaa tggaccccgg gaaagaaggt ccaaacagcc cacaaaacaa accgcctgca      360

gctcctgtta taaatgagta tgccgatgcc cagctacaca acctggtgaa aagaatgcgt      420

caaagaacag ccctctacaa gaaaaagttg gtagagggag atctctcctc acccgaagcc      480

agcccacaaa ctgcaaagcc cacggctgta ccaccagtaa aagaaagcga tgataagcca      540

acagaacatt actacaggct gttgtggttc aaagtcaaaa agatgccttt aacagagtac      600

ttaaagcgaa ttaaacttcc aaacagcata gattcataca cagatcgact ctatctcctg      660

tggctcttgc ttgtcactct tgcctataac tggaactgct gttttatacc actgcgcctc      720

gtcttcccat atcaaaccgc agacaacata cactactggc ttattgcgga catcatatgt      780

gatatcatct acctttatga tatgctattt atccagccca gactccagtt tgtaagagga      840

ggagacataa tagtggattc aaatgagcta aggaaacact acaggacttc tacaaaattt      900

cagttggatg tcgcatcaat aataccattt gatatttgct acctcttctt tgggtttaat      960

ccaatgttta gagcaaatag gatgttaaag tacacttcat tttttgaatt taatcatcac     1020

ctagagtcta taatggacaa agcatatatc tacagagtta ttcgaacaac tggatacttg     1080

ctgtttattc tgcacattaa tgcctgtgtt tattactggg cttcaaacta tgaaggaatt     1140

ggcactacta gatgggtgta tgatggggaa ggaaacgagt atctgagatg ttattattgg     1200

gcagttcgaa ctttaattac cattggtggc cttccagaac cacaaacttt atttgaaatt     1260

gtttttcaac tcttgaattt tttttctgga gtttttgtgt tctccagttt aattggtcag     1320

atgagagatg tgattggagc agctacagcc aatcagaact acttccgcgc ctgcatggat     1380

gacaccattg cctacatgaa caattactcc attcctaaac ttgtgcaaaa gcgagttcgg     1440

acttggtatg aatatacatg ggactctcaa agaatgctag atgagtctga tttgcttaag     1500

accctaccaa ctacggtcca gttagccctc gccattgatg tgaacttcag catcatcagc     1560

aaagtcgact tgttcaaggg ttgtgataca cagatgattt atgacatgtt gctaagattg     1620

aaatccgttc tctatttgcc tggtgacttt gtctgcaaaa agggagaaat tggcaaggaa     1680

atgtatatca tcaagcatgg agaagtccaa gttcttggag gccctgatgg tactaaagtt     1740

ctggttactc tgaaagctgg gtcggtgttt ggagaaatca gccttctagc agcaggagga     1800

ggaaaccgtc gaactgccaa tgtggtggcc cacgggtttg ccaatctttt aactctagac     1860

aaaaagaccc tccaagaaat tctagtgcat tatccagatt ctgaaaggat cctcatgaag     1920

aaagccagag tgcttttaaa gcagaaggct aagaccgcag aagcaacccc tccaagaaaa     1980

gatcttgccc tcctcttccc accgaaagaa gagacaccca aactgtttaa aactctccta     2040

ggaggcacag gaaaagcaag tcttgcaaga ctactcaaat tgaagcgaga gcaagcagct     2100

cagaagaaag aaaattctga aggaggagag gaagaaggaa aagaaaatga agataaacaa     2160

aaagaaaatg aagataaaca aaaagaaaat gaagataaag gaaaagaaaa tgaagataaa     2220

gataaaggaa gagagccaga agagaagcca ctggacagac ctgaatgtac agcaagtcct     2280

attgcagtgg aggaagaacc ccactcagtt agaaggacag ttttacccag agggacttct     2340

cgtcaatcac tcattatcag catggctcct tctgctgagg gcggagaaga ggttcttact     2400

attgaagtca aagaaaaggc taagcaataa                                      2430


<210>  452
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210>  453
<211>  6537
<212>  DNA
<213>  Homo sapiens

<400>  453
atggagacgg ggctgctccc caaccacaaa ctgaaaaccg ttggcgaagc ccccgccgcg       60

ccgccccacc agcagcacca ccaccaccac catgcccacc accaccacca ccatgcccac      120

cacctccacc accaccacgc actacagcag cagctaaacc agttccagca gcagcagcag      180

cagcagcaac agcagcagca gcagcagcag caacagcaac atcccatttc caacaacaac      240

agcttgggcg gcgcgggcgg cggcgcgcct cagcccggcc ccgacatgga gcagccgcaa      300

catggaggcg ccaaggacag tgctgcgggc ggccaggccg accccccggg cccgccgctg      360

ctgagcaagc cgggcgacga ggacgacgcg ccgcccaaga tgggggagcc ggcgggcggc      420

cgctacgagc acccgggctt gggcgccctg ggcacgcagc agccgccggt cgccgtgccc      480

gggggcggcg gcggcccggc ggccgtcccg gagtttaata attactatgg cagcgctgcc      540

cctgcgagcg gcggccccgg cggccgcgct gggccttgct ttgatcaaca tggcggacaa      600

caaagccccg ggatggggat gatgcactcc gcctccgccg ccgccgccgg ggcccccggc      660

agcatggacc ccctgcagaa ctcccacgaa gggtacccca acagccagtg caaccattat      720

ccgggctaca gccggcccgg cgcgggcggc ggcggcggcg gcggcggcgg aggaggagga      780

ggcagcggag gaggaggagg aggaggagga gcaggagcag gaggagcagg agcgggagct      840

gtggcggcgg cggccgcggc ggcggcggca gcagcaggag gcggcggcgg cggcggctat      900

gggggctcgt ccgcggggta cggggtgctg agctcccccc ggcagcaggg cggcggcatg      960

atgatgggcc ccgggggcgg cggggccgcg agcctcagca aggcggccgc cggctcggcg     1020

gcggggggct tccagcgctt cgccggccag aaccagcacc cgtcgggggc caccccgacc     1080

ctcaatcagc tgctcacctc gcccagcccc atgatgcgga gctacggcgg cagctacccc     1140

gagtacagca gccccagcgc gccgccgccg ccgccgtcgc agccccagtc ccaggcggcg     1200

gcggcggggg cggcggcggg cggccagcag gcggccgcgg gcatgggctt gggcaaggac     1260

atgggcgccc agtacgccgc tgccagcccg gcctgggcgg ccgcgcaaca aaggagtcac     1320

ccggcgatga gccccggcac ccccggaccg accatgggca gatcccaggg cagcccaatg     1380

gatccaatgg tgatgaagag acctcagttg tatggcatgg gcagtaaccc tcattctcag     1440

cctcagcaga gcagtccgta cccaggaggt tcctatggcc ctccaggccc acagcggtat     1500

ccaattggca tccagggtcg gactcccggg gccatggccg gaatgcagta ccctcagcag     1560

cagatgccac ctcagtatgg acagcaaggt gtgagtggtt actgccagca gggccaacag     1620

ccatattaca gccagcagcc gcagcccccg cacctcccac cccaggcgca gtatctgccg     1680

tcccagtccc agcagaggta ccagccgcag caggacatgt ctcaggaagg ctatggaact     1740

agatctcaac ctcctctggc ccccggaaaa cctaaccatg aagacttgaa cttaatacag     1800

caagaaagac catcaagttt accagatctg tctggctcca ttgatgacct ccccacggga     1860

acggaagcaa ctttgagctc agcagtcagt gcatccgggt ccacgagcag ccaaggggat     1920

cagagcaacc cggcgcagtc gcctttctcc ccacatgcgt cccctcatct ctccagcatc     1980

ccggggggcc catctccctc tcctgttggc tctcctgtag gaagcaacca gtctcgatct     2040

ggcccaatct ctcctgcaag tatcccaggt agtcagatgc ctccgcagcc acccgggagc     2100

cagtcagaat ccagttccca tcccgccttg agccagtcac caatgccaca ggaaagaggt     2160

tttatggcag gcacacaaag aaaccctcag atggctcagt atggacctca acagacagga     2220

ccatccatgt cgcctcatcc ttctcctggg ggccagatgc atgctggaat cagtagcttt     2280

cagcagagta actcaagtgg gacttacggt ccacagatga gccagtatgg accacaaggt     2340

aactactcca gacccccagc gtatagtggg gtgcccagtg caagctacag cggcccaggg     2400

cccggtatgg gtatcagtgc caacaaccag atgcatggac aagggccaag ccagccatgt     2460

ggtgctgtgc ccctgggacg aatgccatca gctgggatgc agaacagacc atttcctgga     2520

aatatgagca gcatgacccc cagttctcct ggcatgtctc agcagggagg gccaggaatg     2580

gggccgccaa tgccaactgt gaaccgtaag gcacaggagg cagccgcagc agtgatgcag     2640

gctgctgcga actcagcaca aagcaggcaa ggcagtttcc ccggcatgaa ccagagtgga     2700

cttatggctt ccagctctcc ctacagccag cccatgaaca acagctctag cctgatgaac     2760

acgcaggcgc cgccctacag catggcgccc gccatggtga acagctcggc agcatctgtg     2820

ggtcttgcag atatgatgtc tcctggtgaa tccaaactgc ccctgcctct caaagcagac     2880

ggcaaagaag aaggcactcc acagcccgag agcaagtcaa agaagtccag ctcctccacc     2940

actactgggg agaagatcac gaaggtgtac gagctgggga atgagccaga gagaaagctc     3000

tgggtcgacc gatacctcac cttcatggaa gagagaggct ctcctgtctc aagtctgcct     3060

gccgtgggca agaagcccct ggacctgttc cgactctacg tctgcgtcaa agagatcggg     3120

ggtttggccc aggttaataa aaacaagaag tggcgtgagc tggcaaccaa cctaaacgtt     3180

ggcacctcaa gcagtgcagc gagctccctg aaaaagcagt atattcagta cctgtttgcc     3240

tttgagtgca agatcgaacg tggggaggag cccccgccgg aagtcttcag caccggggac     3300

accaaaaagc agcccaagct ccagccgcca tctcctgcta actcgggatc cttgcaaggc     3360

ccacagaccc cccagtcaac tggcagcaat tccatggcag aggttccagg tgacctgaag     3420

ccacctaccc cagcctccac ccctcacggc cagatgactc caatgcaagg tggaagaagc     3480

agtacaatca gtgtgcacga cccattctca gatgtgagtg attcatcctt cccgaaacgg     3540

aactccatga ctccaaacgc cccctaccag cagggcatga gcatgcccga tgtgatgggc     3600

aggatgccct atgagcccaa caaggacccc tttgggggaa tgagaaaagt gcctggaagc     3660

agcgagccct ttatgacgca aggacagatg cccaacagca gcatgcagga catgtacaac     3720

caaagtccct ccggagcaat gtctaacctg ggcatggggc agcgccagca gtttccctat     3780

ggagccagtt acgaccgaag gcatgaacct tatgggcagc agtatccagg ccaaggccct     3840

ccctcgggac agccgccgta tggagggcac cagcccggcc tgtacccaca gcagccgaat     3900

tacaaacgcc atatggacgg catgtacggg cccccagcca agcgccacga gggcgacatg     3960

tacaacatgc agtacagcag ccagcagcag gagatgtaca accagtatgg aggctcctac     4020

tcgggcccgg accgcaggcc catccagggc cagtacccgt atccctacag cagggagagg     4080

atgcagggcc cggggcagat ccagacacac ggaatcccgc ctcagatgat gggcggcccg     4140

ctgcagtcgt cctccagtga ggggcctcag cagaatatgt gggcagcacg caatgatatg     4200

ccttatccct accagaacag gcagggccct ggcggcccta cacaggcgcc cccttaccca     4260

ggcatgaacc gcacagacga tatgatggta cccgatcaga ggataaatca tgagagccag     4320

tggccttctc acgtcagcca gcgtcagcct tatatgtcgt cctcagcctc catgcagccc     4380

atcacacgcc caccacagcc gtcctaccag acgccaccgt cactgccaaa tcacatctcc     4440

agggcgccca gcccagcgtc cttccagcgc tccctggaga accgcatgtc tccaagcaag     4500

tctccttttc tgccgtctat gaagatgcag aaggtcatgc ccacggtccc cacatcccag     4560

gtcaccgggc caccacccca accaccccca atcagaaggg agatcacctt tcctcctggc     4620

tcagtagaag catcacaacc agtcttgaaa caaaggcgaa agattacctc caaagatatc     4680

gttactcctg aggcgtggcg tgtgatgatg tcccttaaat caggtctttt ggctgagagt     4740

acgtgggctt tggacactat taatattctt ctgtatgatg acagcactgt tgctactttc     4800

aatctctccc agttgtctgg atttctcgaa cttttagtcg agtactttag aaaatgcctg     4860

attgacattt ttggaattct tatggaatat gaagtgggag accccagcca aaaagcactt     4920

gatcacaacg cagcaaggaa ggatgacagc cagtccttgg cagacgattc tgggaaagag     4980

gaggaagatg ctgaatgtat tgatgacgac gaggaagacg aggaggatga ggaggaagac     5040

agcgagaaga cagaaagcga tgaaaagagc agcatcgctc tgactgcccc ggacgccgct     5100

gcagacccaa aggagaagcc caagcaagcc agtaagttcg acaagctgcc aataaagata     5160

gtcaaaaaga acaacctgtt tgttgttgac cgatctgaca agttggggcg tgtgcaggag     5220

ttcaatagtg gccttctgca ctggcagctc ggcgggggtg acaccaccga gcacattcag     5280

actcactttg agagcaagat ggaaattcct cctcgcaggc gcccacctcc ccccttaagc     5340

tccgcaggta gaaagaaaga gcaagaaggc aaaggcgact ctgaagagca gcaagagaaa     5400

agcatcatag caaccatcga tgacgtcctc tctgctcggc caggggcatt gcctgaagac     5460

gcaaaccctg ggccccagac cgaaagcagt aagtttccct ttggtatcca gcaagccaaa     5520

agtcaccgga acatcaagct gctggaggac gagcccagga gccgagacga gactcctctg     5580

tgtaccatcg cgcactggca ggactcgctg gctaagcgat gcatctgtgt gtccaatatt     5640

gtccgtagct tgtcattcgt gcctggcaat gatgccgaaa tgtccaaaca tccaggcctg     5700

gtgctgatcc tggggaagct gattcttctt caccacgagc atccagagag aaagcgagca     5760

ccgcagacct atgagaaaga ggaggatgag gacaaggggg tggcctgcag caaagatgag     5820

tggtggtggg actgcctcga ggtcttgagg gataacacgt tggtcacgtt ggccaacatt     5880

tccgggcagc tagacttgtc tgcttacacg gaaagcatct gcttgccaat tttggatggc     5940

ttgctgcact ggatggtgtg cccgtctgca gaggcacaag atccctttcc aactgtggga     6000

cccaactcgg tcctgtcgcc tcagagactt gtgctggaga ccctctgtaa actcagtatc     6060

caggacaata atgtggacct gatcttggcc actcctccat ttagtcgtca ggagaaattc     6120

tatgctacat tagttaggta cgttggggat cgcaaaaacc cagtctgtcg agaaatgtcc     6180

atggcgcttt tatcgaacct tgcccaaggg gacgcactag cagcaagggc catagctgtg     6240

cagaaaggaa gcattggaaa cttgataagc ttcctagagg atggggtcac gatggcccag     6300

taccagcaga gccagcacaa cctcatgcac atgcagcccc cgcccctgga accacctagc     6360

gtagacatga tgtgcagggc ggccaaggct ttgctagcca tggccagagt ggacgaaaac     6420

cgctcggaat tccttttgca cgagggccgg ttgctggata tctcgatatc agctgtcctg     6480

aactctctgg ttgcatctgt catctgtgat gtactgtttc agattgggca gttatga        6537


<210>  454
<211>  2178
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu 
1               5                   10                  15      


Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala 
            20                  25                  30          


His His His His His His Ala His His Leu His His His His Ala Leu 
        35                  40                  45              


Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met 
                85                  90                  95      


Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln 
            100                 105                 110         


Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp 
        115                 120                 125             


Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His 
    130                 135                 140                 


Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr 
                165                 170                 175     


Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro 
            180                 185                 190         


Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met 
        195                 200                 205             


His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro 
    210                 215                 220                 


Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr 
225                 230                 235                 240 


Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
            260                 265                 270         


Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met 
305                 310                 315                 320 


Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala 
                325                 330                 335     


Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln 
            340                 345                 350         


His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro 
        355                 360                 365             


Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser 
    370                 375                 380                 


Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala 
385                 390                 395                 400 


Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly 
                405                 410                 415     


Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp 
            420                 425                 430         


Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro 
        435                 440                 445             


Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
    450                 455                 460                 


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
465                 470                 475                 480 


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
                485                 490                 495     


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met 
            500                 505                 510         


Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln 
        515                 520                 525             


Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser 
    530                 535                 540                 


Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro 
545                 550                 555                 560 


Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu 
                565                 570                 575     


Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn 
            580                 585                 590         


His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro 
        595                 600                 605             


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr 
    610                 615                 620                 


Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp 
625                 630                 635                 640 


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His 
                645                 650                 655     


Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
            660                 665                 670         


Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile 
        675                 680                 685             


Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser 
    690                 695                 700                 


Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly 
705                 710                 715                 720 


Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro 
                725                 730                 735     


Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln 
            740                 745                 750         


Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr 
        755                 760                 765             


Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg 
    770                 775                 780                 


Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly 
785                 790                 795                 800 


Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro 
                805                 810                 815     


Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly 
            820                 825                 830         


Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser 
        835                 840                 845             


Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met 
    850                 855                 860                 


Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln 
865                 870                 875                 880 


Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met 
                885                 890                 895     


Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met 
            900                 905                 910         


Asn Asn Ser Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met 
        915                 920                 925             


Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp 
    930                 935                 940                 


Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp 
945                 950                 955                 960 


Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser 
                965                 970                 975     


Ser Ser Ser Thr Thr Thr Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu 
            980                 985                 990         


Gly Asn Glu Pro Glu Arg Lys Leu  Trp Val Asp Arg Tyr  Leu Thr Phe 
        995                 1000                 1005             


Met Glu  Glu Arg Gly Ser Pro  Val Ser Ser Leu Pro  Ala Val Gly 
    1010                 1015                 1020             


Lys Lys  Pro Leu Asp Leu Phe  Arg Leu Tyr Val Cys  Val Lys Glu 
    1025                 1030                 1035             


Ile Gly  Gly Leu Ala Gln Val  Asn Lys Asn Lys Lys  Trp Arg Glu 
    1040                 1045                 1050             


Leu Ala  Thr Asn Leu Asn Val  Gly Thr Ser Ser Ser  Ala Ala Ser 
    1055                 1060                 1065             


Ser Leu  Lys Lys Gln Tyr Ile  Gln Tyr Leu Phe Ala  Phe Glu Cys 
    1070                 1075                 1080             


Lys Ile  Glu Arg Gly Glu Glu  Pro Pro Pro Glu Val  Phe Ser Thr 
    1085                 1090                 1095             


Gly Asp  Thr Lys Lys Gln Pro  Lys Leu Gln Pro Pro  Ser Pro Ala 
    1100                 1105                 1110             


Asn Ser  Gly Ser Leu Gln Gly  Pro Gln Thr Pro Gln  Ser Thr Gly 
    1115                 1120                 1125             


Ser Asn  Ser Met Ala Glu Val  Pro Gly Asp Leu Lys  Pro Pro Thr 
    1130                 1135                 1140             


Pro Ala  Ser Thr Pro His Gly  Gln Met Thr Pro Met  Gln Gly Gly 
    1145                 1150                 1155             


Arg Ser  Ser Thr Ile Ser Val  His Asp Pro Phe Ser  Asp Val Ser 
    1160                 1165                 1170             


Asp Ser  Ser Phe Pro Lys Arg  Asn Ser Met Thr Pro  Asn Ala Pro 
    1175                 1180                 1185             


Tyr Gln  Gln Gly Met Ser Met  Pro Asp Val Met Gly  Arg Met Pro 
    1190                 1195                 1200             


Tyr Glu  Pro Asn Lys Asp Pro  Phe Gly Gly Met Arg  Lys Val Pro 
    1205                 1210                 1215             


Gly Ser  Ser Glu Pro Phe Met  Thr Gln Gly Gln Met  Pro Asn Ser 
    1220                 1225                 1230             


Ser Met  Gln Asp Met Tyr Asn  Gln Ser Pro Ser Gly  Ala Met Ser 
    1235                 1240                 1245             


Asn Leu  Gly Met Gly Gln Arg  Gln Gln Phe Pro Tyr  Gly Ala Ser 
    1250                 1255                 1260             


Tyr Asp  Arg Arg His Glu Pro  Tyr Gly Gln Gln Tyr  Pro Gly Gln 
    1265                 1270                 1275             


Gly Pro  Pro Ser Gly Gln Pro  Pro Tyr Gly Gly His  Gln Pro Gly 
    1280                 1285                 1290             


Leu Tyr  Pro Gln Gln Pro Asn  Tyr Lys Arg His Met  Asp Gly Met 
    1295                 1300                 1305             


Tyr Gly  Pro Pro Ala Lys Arg  His Glu Gly Asp Met  Tyr Asn Met 
    1310                 1315                 1320             


Gln Tyr  Ser Ser Gln Gln Gln  Glu Met Tyr Asn Gln  Tyr Gly Gly 
    1325                 1330                 1335             


Ser Tyr  Ser Gly Pro Asp Arg  Arg Pro Ile Gln Gly  Gln Tyr Pro 
    1340                 1345                 1350             


Tyr Pro  Tyr Ser Arg Glu Arg  Met Gln Gly Pro Gly  Gln Ile Gln 
    1355                 1360                 1365             


Thr His  Gly Ile Pro Pro Gln  Met Met Gly Gly Pro  Leu Gln Ser 
    1370                 1375                 1380             


Ser Ser  Ser Glu Gly Pro Gln  Gln Asn Met Trp Ala  Ala Arg Asn 
    1385                 1390                 1395             


Asp Met  Pro Tyr Pro Tyr Gln  Asn Arg Gln Gly Pro  Gly Gly Pro 
    1400                 1405                 1410             


Thr Gln  Ala Pro Pro Tyr Pro  Gly Met Asn Arg Thr  Asp Asp Met 
    1415                 1420                 1425             


Met Val  Pro Asp Gln Arg Ile  Asn His Glu Ser Gln  Trp Pro Ser 
    1430                 1435                 1440             


His Val  Ser Gln Arg Gln Pro  Tyr Met Ser Ser Ser  Ala Ser Met 
    1445                 1450                 1455             


Gln Pro  Ile Thr Arg Pro Pro  Gln Pro Ser Tyr Gln  Thr Pro Pro 
    1460                 1465                 1470             


Ser Leu  Pro Asn His Ile Ser  Arg Ala Pro Ser Pro  Ala Ser Phe 
    1475                 1480                 1485             


Gln Arg  Ser Leu Glu Asn Arg  Met Ser Pro Ser Lys  Ser Pro Phe 
    1490                 1495                 1500             


Leu Pro  Ser Met Lys Met Gln  Lys Val Met Pro Thr  Val Pro Thr 
    1505                 1510                 1515             


Ser Gln  Val Thr Gly Pro Pro  Pro Gln Pro Pro Pro  Ile Arg Arg 
    1520                 1525                 1530             


Glu Ile  Thr Phe Pro Pro Gly  Ser Val Glu Ala Ser  Gln Pro Val 
    1535                 1540                 1545             


Leu Lys  Gln Arg Arg Lys Ile  Thr Ser Lys Asp Ile  Val Thr Pro 
    1550                 1555                 1560             


Glu Ala  Trp Arg Val Met Met  Ser Leu Lys Ser Gly  Leu Leu Ala 
    1565                 1570                 1575             


Glu Ser  Thr Trp Ala Leu Asp  Thr Ile Asn Ile Leu  Leu Tyr Asp 
    1580                 1585                 1590             


Asp Ser  Thr Val Ala Thr Phe  Asn Leu Ser Gln Leu  Ser Gly Phe 
    1595                 1600                 1605             


Leu Glu  Leu Leu Val Glu Tyr  Phe Arg Lys Cys Leu  Ile Asp Ile 
    1610                 1615                 1620             


Phe Gly  Ile Leu Met Glu Tyr  Glu Val Gly Asp Pro  Ser Gln Lys 
    1625                 1630                 1635             


Ala Leu  Asp His Asn Ala Ala  Arg Lys Asp Asp Ser  Gln Ser Leu 
    1640                 1645                 1650             


Ala Asp  Asp Ser Gly Lys Glu  Glu Glu Asp Ala Glu  Cys Ile Asp 
    1655                 1660                 1665             


Asp Asp  Glu Glu Asp Glu Glu  Asp Glu Glu Glu Asp  Ser Glu Lys 
    1670                 1675                 1680             


Thr Glu  Ser Asp Glu Lys Ser  Ser Ile Ala Leu Thr  Ala Pro Asp 
    1685                 1690                 1695             


Ala Ala  Ala Asp Pro Lys Glu  Lys Pro Lys Gln Ala  Ser Lys Phe 
    1700                 1705                 1710             


Asp Lys  Leu Pro Ile Lys Ile  Val Lys Lys Asn Asn  Leu Phe Val 
    1715                 1720                 1725             


Val Asp  Arg Ser Asp Lys Leu  Gly Arg Val Gln Glu  Phe Asn Ser 
    1730                 1735                 1740             


Gly Leu  Leu His Trp Gln Leu  Gly Gly Gly Asp Thr  Thr Glu His 
    1745                 1750                 1755             


Ile Gln  Thr His Phe Glu Ser  Lys Met Glu Ile Pro  Pro Arg Arg 
    1760                 1765                 1770             


Arg Pro  Pro Pro Pro Leu Ser  Ser Ala Gly Arg Lys  Lys Glu Gln 
    1775                 1780                 1785             


Glu Gly  Lys Gly Asp Ser Glu  Glu Gln Gln Glu Lys  Ser Ile Ile 
    1790                 1795                 1800             


Ala Thr  Ile Asp Asp Val Leu  Ser Ala Arg Pro Gly  Ala Leu Pro 
    1805                 1810                 1815             


Glu Asp  Ala Asn Pro Gly Pro  Gln Thr Glu Ser Ser  Lys Phe Pro 
    1820                 1825                 1830             


Phe Gly  Ile Gln Gln Ala Lys  Ser His Arg Asn Ile  Lys Leu Leu 
    1835                 1840                 1845             


Glu Asp  Glu Pro Arg Ser Arg  Asp Glu Thr Pro Leu  Cys Thr Ile 
    1850                 1855                 1860             


Ala His  Trp Gln Asp Ser Leu  Ala Lys Arg Cys Ile  Cys Val Ser 
    1865                 1870                 1875             


Asn Ile  Val Arg Ser Leu Ser  Phe Val Pro Gly Asn  Asp Ala Glu 
    1880                 1885                 1890             


Met Ser  Lys His Pro Gly Leu  Val Leu Ile Leu Gly  Lys Leu Ile 
    1895                 1900                 1905             


Leu Leu  His His Glu His Pro  Glu Arg Lys Arg Ala  Pro Gln Thr 
    1910                 1915                 1920             


Tyr Glu  Lys Glu Glu Asp Glu  Asp Lys Gly Val Ala  Cys Ser Lys 
    1925                 1930                 1935             


Asp Glu  Trp Trp Trp Asp Cys  Leu Glu Val Leu Arg  Asp Asn Thr 
    1940                 1945                 1950             


Leu Val  Thr Leu Ala Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Ala 
    1955                 1960                 1965             


Tyr Thr  Glu Ser Ile Cys Leu  Pro Ile Leu Asp Gly  Leu Leu His 
    1970                 1975                 1980             


Trp Met  Val Cys Pro Ser Ala  Glu Ala Gln Asp Pro  Phe Pro Thr 
    1985                 1990                 1995             


Val Gly  Pro Asn Ser Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu 
    2000                 2005                 2010             


Thr Leu  Cys Lys Leu Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile 
    2015                 2020                 2025             


Leu Ala  Thr Pro Pro Phe Ser  Arg Gln Glu Lys Phe  Tyr Ala Thr 
    2030                 2035                 2040             


Leu Val  Arg Tyr Val Gly Asp  Arg Lys Asn Pro Val  Cys Arg Glu 
    2045                 2050                 2055             


Met Ser  Met Ala Leu Leu Ser  Asn Leu Ala Gln Gly  Asp Ala Leu 
    2060                 2065                 2070             


Ala Ala  Arg Ala Ile Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu 
    2075                 2080                 2085             


Ile Ser  Phe Leu Glu Asp Gly  Val Thr Met Ala Gln  Tyr Gln Gln 
    2090                 2095                 2100             


Ser Gln  His Asn Leu Met His  Met Gln Pro Pro Pro  Leu Glu Pro 
    2105                 2110                 2115             


Pro Ser  Val Asp Met Met Cys  Arg Ala Ala Lys Ala  Leu Leu Ala 
    2120                 2125                 2130             


Met Ala  Arg Val Asp Glu Asn  Arg Ser Glu Phe Leu  Leu His Glu 
    2135                 2140                 2145             


Gly Arg  Leu Leu Asp Ile Ser  Ile Ser Ala Val Leu  Asn Ser Leu 
    2150                 2155                 2160             


Val Ala  Ser Val Ile Cys Asp  Val Leu Phe Gln Ile  Gly Gln Leu 
    2165                 2170                 2175             


<210>  455
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  455
atggagaagc tgttgtgttt cttggtcttg accagcctct ctcatgcttt tggccagaca       60

gacatgtcga ggaaggcttt tgtgtttccc aaagagtcgg atacttccta tgtatccctc      120

aaagcaccgt taacgaagcc tctcaaagcc ttcactgtgt gcctccactt ctacacggaa      180

ctgtcctcga cccgtgggta cagtattttc tcgtatgcca ccaagagaca agacaatgag      240

attctcatat tttggtctaa ggatatagga tacagtttta cagtgggtgg gtctgaaata      300

ttattcgagg ttcctgaagt cacagtagct ccagtacaca tttgtacaag ctgggagtcc      360

gcctcaggga tcgtggagtt ctgggtagat gggaagccca gggtgaggaa gagtctgaag      420

aagggataca ctgtgggggc agaagcaagc atcatcttgg ggcaggagca ggattccttc      480

ggtgggaact ttgaaggaag ccagtccctg gtgggagaca ttggaaatgt gaacatgtgg      540

gactttgtgc tgtcaccaga tgagattaac accatctatc ttggcgggcc cttcagtcct      600

aatgtcctga actggcgggc actgaagtat gaagtgcaag gcgaagtgtt caccaaaccc      660

cagctgtggc cctga                                                       675


<210>  456
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  457
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  457
atgcctgagg aaacccagac ccaagaccaa ccgatggagg aggaggaggt tgagacgttc       60

gcctttcagg cagaaattgc ccagttgatg tcattgatca tcaatacttt ctactcgaac      120

aaagagatct ttctgagaga gctcatttca aattcatcag atgcattgga caaaatccgg      180

tatgaaagct tgacagatcc cagtaaatta gactctggga aagagctgca tattaacctt      240

ataccgaaca aacaagatcg aactctcact attgtggata ctggaattgg aatgaccaag      300

gctgacttga tcaataacct tggtactatc gccaagtctg ggaccaaagc gttcatggaa      360

gctttgcagg ctggtgcaga tatctctatg attggccagt tcggtgttgg tttttattct      420

gcttatttgg ttgctgagaa agtaactgtg atcaccaaac ataacgatga tgagcagtac      480

gcttgggagt cctcagcagg gggatcattc acagtgagga cagacacagg tgaacctatg      540

ggtcgtggaa caaaagttat cctacacctg aaagaagacc aaactgagta cttggaggaa      600

cgaagaataa aggagattgt gaagaaacat tctcagttta ttggatatcc cattactctt      660

tttgtggaga aggaacgtga taaagaagta agcgatgatg aggctgaaga aaaggaagac      720

aaagaagaag aaaaagaaaa agaagagaaa gagtcggaag acaaacctga aattgaagat      780

gttggttctg atgaggaaga agaaaagaag gatggtgaca agaagaagaa gaagaagatt      840

aaggaaaagt acatcgatca agaagagctc aacaaaacaa agcccatctg gaccagaaat      900

cccgacgata ttactaatga ggagtacgga gaattctata agagcttgac caatgactgg      960

gaagatcact tggcagtgaa gcatttttca gttgaaggac agttggaatt cagagccctt     1020

ctatttgtcc cacgacgtgc tccttttgat ctgtttgaaa acagaaagaa aaagaacaac     1080

atcaaattgt atgtacgcag agttttcatc atggataact gtgaggagct aatccctgaa     1140

tatctgaact tcattagagg ggtggtagac tcggaggatc tccctctaaa catatcccgt     1200

gagatgttgc aacaaagcaa aattttgaaa gttatcagga agaatttggt caaaaaatgc     1260

ttagaactct ttactgaact ggcggaagat aaagagaact acaagaaatt ctatgagcag     1320

ttctctaaaa acataaagct tggaatacac gaagactctc aaaatcggaa gaagctttca     1380

gagctgttaa ggtactacac atctgcctct ggtgatgaga tggtttctct caaggactac     1440

tgcaccagaa tgaaggagaa ccagaaacat atctattata tcacaggtga gaccaaggac     1500

caggtagcta actcagcctt tgtggaacgt cttcggaaac atggcttaga agtgatctat     1560

atgattgagc ccattgatga gtactgtgtc caacagctga aggaatttga ggggaagact     1620

ttagtgtcag tcaccaaaga aggcctggaa cttccagagg atgaagaaga gaaaaagaag     1680

caggaagaga aaaaaacaaa gtttgagaac ctctgcaaaa tcatgaaaga catattggag     1740

aaaaaagttg aaaaggtggt tgtgtcaaac cgattggtga catctccatg ctgtattgtc     1800

acaagcacat atggctggac agcaaacatg gagagaatca tgaaagctca agccctaaga     1860

gacaactcaa caatgggtta catggcagca aagaaacacc tggagataaa ccctgaccat     1920

tccattattg agaccttaag gcaaaaggca gaggctgata agaacgacaa gtctgtgaag     1980

gatctggtca tcttgcttta tgaaactgcg ctcctgtctt ctggcttcag tctggaagat     2040

ccccagacac atgctaacag gatctacagg atgatcaaac ttggtctggg tattgatgaa     2100

gatgacccta ctgctgatga taccagtgct gctgtaactg aagaaatgcc accccttgaa     2160

ggagatgacg acacatcacg catggaagaa gtagactaa                            2199


<210>  458
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             


Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 


Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 


Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     


Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         


Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             


Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 


Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 


Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     


Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         


Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             


Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 


Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 


Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     


Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         


Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             


Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 


Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 


Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         


Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 


Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 


Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     


Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         


Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             


Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 


Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 


Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         


<210>  459
<211>  2076
<212>  DNA
<213>  Homo sapiens

<400>  459
atgaacgcgg cggtggtgag gcggacgcag gaggcgctgg ggaaagtgat tcggaggccg       60

ccgctgaccg agaagctgct gagcaagccc ccgttccgct acctgcacga catcatcacg      120

gaggtgatta gaatgactgg tttcatgaag ggcctctaca cagacgccga gatgaagtct      180

gataatgtga aggataaaga tgcaaaaatt agcttcctac aaaaggccat agacgtggtt      240

gtaatggtgt cgggagagcc actgttggcc aaaccagccc gaatcgtggc ggggcatgag      300

cctgaaagaa caaacgagct gctccagata attggaaaat gctgtctcaa caagctctct      360

agtgacgatg cggtgcggag ggttttagct ggagagaagg gagaagtgaa aggccgggcc      420

tcactgacct caagatctca ggaattggat aataagaatg tgcgagaaga agagtccaga      480

gttcacaaaa atacagagga tagaggagac gctgaaataa aagagagaag tacaagcaga      540

gatcgaaaac agaaggaaga attgaaagaa gaccgcaagc caagagaaaa ggacaaggac      600

aaggagaagg ccaaggagaa tggcggaaac agacacagag aaggggagag agagagagcc      660

aaagcccggg ccaggccaga caacgagcga cagaaagaca gaggcaacag ggagcgggac      720

agagactccg agcgcaagaa ggagacagag agaaagagtg agggggggaa agagaaggag      780

agactgagag acagggaccg agagcgcgac cgggacaaag ggaaggacag ggacagacgg      840

agagtgaaaa acggggagca ctcctgggac ctggacaggg agaagaacag agagcatgac      900

aaacctgaga aaaagtcagc aagctcaggg gagatgtcta aaaagttatc agatggaact      960

tttaaagact ccaaggctga aacagagact gagatttcca ctagagcttc caagtcattg     1020

acaacaaaaa catcaaaacg gcgatccaaa aattcagtgg aaggaaggaa ggaggataat     1080

atttcagcta aaagtttaga ctccatagtg tctggaataa ataatgagcc aaatcaggaa     1140

acgacaacat cagaaatagg aacaaaagaa gctaatatta actcaactag tatttcagat     1200

gataattcag ctagtctgcg gtgtgagaat attcagccca accccacaga gaagcagaaa     1260

ggtgactcca ccagtgatgc agaaggagat gctggacctg ctggccaaga taagtctgag     1320

gtgccagaga ctccagaaat tcctaatgag ctttcatcca acatcagaag aattcctcgg     1380

cctgggagtg caagaccagc ccctccccgg gtcaaacggc aagacagcat ggaggcgcta     1440

caaatggata ggtcagggag tggtaaaacc gtttcaaatg tgattacaga gtcacacaat     1500

tctgacaatg aagaggatga tcaatttgtg gtggaagctg cccctcagct ctctgaaatg     1560

tcagaaattg aaatggtaac agcagtggaa ctagaagaag aggagaagca tggtggactt     1620

gtgaaaaaaa ttttggagac gaagaaagat tatgagaaat tgcagcagtc acccaaacct     1680

ggggagaagg agcgatctct ctttgagtcg gcatggaaga aggagaagga catcgtttcc     1740

aaggagatag agaagctccg cacgtccatc cagaccctgt gcaagagcgc acttcccctg     1800

gggaagatca tggactacat ccaggaagac gtggatgcca tgcagaatga gctgcagatg     1860

tggcacagcg agaacaggca gcacgccgag gccctgcagc aggagcagag gatcacagac     1920

tgtgccgtgg agcccttaaa ggctgagctc gcggagctgg agcagctgat caaagaccag     1980

caagacaaga tctgtgctgt gaaggccaac atcctcaaga atgaagaaaa aatccagaaa     2040

atggtatata gtatcaattt gacttcgaga aggtga                               2076


<210>  460
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Asn Ala Ala Val Val Arg Arg Thr Gln Glu Ala Leu Gly Lys Val 
1               5                   10                  15      


Ile Arg Arg Pro Pro Leu Thr Glu Lys Leu Leu Ser Lys Pro Pro Phe 
            20                  25                  30          


Arg Tyr Leu His Asp Ile Ile Thr Glu Val Ile Arg Met Thr Gly Phe 
        35                  40                  45              


Met Lys Gly Leu Tyr Thr Asp Ala Glu Met Lys Ser Asp Asn Val Lys 
    50                  55                  60                  


Asp Lys Asp Ala Lys Ile Ser Phe Leu Gln Lys Ala Ile Asp Val Val 
65                  70                  75                  80  


Val Met Val Ser Gly Glu Pro Leu Leu Ala Lys Pro Ala Arg Ile Val 
                85                  90                  95      


Ala Gly His Glu Pro Glu Arg Thr Asn Glu Leu Leu Gln Ile Ile Gly 
            100                 105                 110         


Lys Cys Cys Leu Asn Lys Leu Ser Ser Asp Asp Ala Val Arg Arg Val 
        115                 120                 125             


Leu Ala Gly Glu Lys Gly Glu Val Lys Gly Arg Ala Ser Leu Thr Ser 
    130                 135                 140                 


Arg Ser Gln Glu Leu Asp Asn Lys Asn Val Arg Glu Glu Glu Ser Arg 
145                 150                 155                 160 


Val His Lys Asn Thr Glu Asp Arg Gly Asp Ala Glu Ile Lys Glu Arg 
                165                 170                 175     


Ser Thr Ser Arg Asp Arg Lys Gln Lys Glu Glu Leu Lys Glu Asp Arg 
            180                 185                 190         


Lys Pro Arg Glu Lys Asp Lys Asp Lys Glu Lys Ala Lys Glu Asn Gly 
        195                 200                 205             


Gly Asn Arg His Arg Glu Gly Glu Arg Glu Arg Ala Lys Ala Arg Ala 
    210                 215                 220                 


Arg Pro Asp Asn Glu Arg Gln Lys Asp Arg Gly Asn Arg Glu Arg Asp 
225                 230                 235                 240 


Arg Asp Ser Glu Arg Lys Lys Glu Thr Glu Arg Lys Ser Glu Gly Gly 
                245                 250                 255     


Lys Glu Lys Glu Arg Leu Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp 
            260                 265                 270         


Lys Gly Lys Asp Arg Asp Arg Arg Arg Val Lys Asn Gly Glu His Ser 
        275                 280                 285             


Trp Asp Leu Asp Arg Glu Lys Asn Arg Glu His Asp Lys Pro Glu Lys 
    290                 295                 300                 


Lys Ser Ala Ser Ser Gly Glu Met Ser Lys Lys Leu Ser Asp Gly Thr 
305                 310                 315                 320 


Phe Lys Asp Ser Lys Ala Glu Thr Glu Thr Glu Ile Ser Thr Arg Ala 
                325                 330                 335     


Ser Lys Ser Leu Thr Thr Lys Thr Ser Lys Arg Arg Ser Lys Asn Ser 
            340                 345                 350         


Val Glu Gly Arg Lys Glu Asp Asn Ile Ser Ala Lys Ser Leu Asp Ser 
        355                 360                 365             


Ile Val Ser Gly Ile Asn Asn Glu Pro Asn Gln Glu Thr Thr Thr Ser 
    370                 375                 380                 


Glu Ile Gly Thr Lys Glu Ala Asn Ile Asn Ser Thr Ser Ile Ser Asp 
385                 390                 395                 400 


Asp Asn Ser Ala Ser Leu Arg Cys Glu Asn Ile Gln Pro Asn Pro Thr 
                405                 410                 415     


Glu Lys Gln Lys Gly Asp Ser Thr Ser Asp Ala Glu Gly Asp Ala Gly 
            420                 425                 430         


Pro Ala Gly Gln Asp Lys Ser Glu Val Pro Glu Thr Pro Glu Ile Pro 
        435                 440                 445             


Asn Glu Leu Ser Ser Asn Ile Arg Arg Ile Pro Arg Pro Gly Ser Ala 
    450                 455                 460                 


Arg Pro Ala Pro Pro Arg Val Lys Arg Gln Asp Ser Met Glu Ala Leu 
465                 470                 475                 480 


Gln Met Asp Arg Ser Gly Ser Gly Lys Thr Val Ser Asn Val Ile Thr 
                485                 490                 495     


Glu Ser His Asn Ser Asp Asn Glu Glu Asp Asp Gln Phe Val Val Glu 
            500                 505                 510         


Ala Ala Pro Gln Leu Ser Glu Met Ser Glu Ile Glu Met Val Thr Ala 
        515                 520                 525             


Val Glu Leu Glu Glu Glu Glu Lys His Gly Gly Leu Val Lys Lys Ile 
    530                 535                 540                 


Leu Glu Thr Lys Lys Asp Tyr Glu Lys Leu Gln Gln Ser Pro Lys Pro 
545                 550                 555                 560 


Gly Glu Lys Glu Arg Ser Leu Phe Glu Ser Ala Trp Lys Lys Glu Lys 
                565                 570                 575     


Asp Ile Val Ser Lys Glu Ile Glu Lys Leu Arg Thr Ser Ile Gln Thr 
            580                 585                 590         


Leu Cys Lys Ser Ala Leu Pro Leu Gly Lys Ile Met Asp Tyr Ile Gln 
        595                 600                 605             


Glu Asp Val Asp Ala Met Gln Asn Glu Leu Gln Met Trp His Ser Glu 
    610                 615                 620                 


Asn Arg Gln His Ala Glu Ala Leu Gln Gln Glu Gln Arg Ile Thr Asp 
625                 630                 635                 640 


Cys Ala Val Glu Pro Leu Lys Ala Glu Leu Ala Glu Leu Glu Gln Leu 
                645                 650                 655     


Ile Lys Asp Gln Gln Asp Lys Ile Cys Ala Val Lys Ala Asn Ile Leu 
            660                 665                 670         


Lys Asn Glu Glu Lys Ile Gln Lys Met Val Tyr Ser Ile Asn Leu Thr 
        675                 680                 685             


Ser Arg Arg 
    690     


<210>  461
<211>  2469
<212>  DNA
<213>  Homo sapiens

<400>  461
atgaagccag ccctcctgcc ctgggccctg ctgctgctgg cgacagccct cggcccgggc       60

cccggaccca cagcagatgc ccaagagagc tgctccatgc gctgtggcgc cctggacggg      120

ccatgttcct gccacccgac gtgctctggc cttggcacct gctgcttgga tttccgggac      180

ttctgcctgg agatattgcc ctactcagga tccatgatgg gcggcaagga ctttgtggtg      240

cggcacttca agatgtccag ccccacagac gccagtgtga tctgcaggtt taaggacagc      300

atccagaccc tcggccatgt ggactcctcc gggcaagtgc actgtgtgtc acctctgctc      360

tatgagagcg gccgcatccc cttcactgtg tcactggaca acggccactc cttccctcgt      420

gcgggcacct ggctggctgt gcaccccaac aaagtgtcaa tgatggagaa gagcgagttg      480

gtgaacgaga cgcgttggca atactacggc accgccaaca cctcaggcaa cctcagcctg      540

acctggcatg tcaagtcgct gcccacgcag accatcacca tcgaactgtg gggctacgag      600

gagacaggaa tgccctactc acaggagtgg actgcaaagt ggtcgtacct gtaccccctg      660

gccacacaca tccccaactc cggctctttc actttcaccc caaaacctgc tcctcccagc      720

taccagagat ggcgagtggg tgcacttcgg atcatcgaca gcaaaaatta cgcagggcag      780

aaggacgtgc aggcgctctg gaccaacgac cacgcactgg cctggcacct gagcgatgac      840

ttccgagagg accctgtggc ctgggcacga actcagtgcc aggcctggga ggagctggag      900

gatcagctgc ccaacttcct ggaggagctg ccggactgcc cctgcaccct gacccaggcc      960

cgggctgact ccggccgctt cttcacggac tacggctgtg acatggagca gggcagcgtg     1020

tgcacctacc accccggggc cgtgcactgt gtgcgttctg tgcaggccag cctccggtac     1080

ggctcaggtc agcagtgctg ctacacagcg gacgggacgc agctcctgac agctgactcc     1140

agcggcggca gcactcccga ccgcggccat gactggggcg cacccccgtt ccgcacgcca     1200

ccccgagtgc ccagcatgtc ccactggctc tacgatgtcc tcagcttcta ttactgctgc     1260

ctctgggcac ccgactgccc ccgctacatg caacggcggc cctccaatga ctgccgcaac     1320

taccggcccc caagactggc ctccgccttc ggagacccac actttgtgac cttcgacggc     1380

accaacttca cattcaatgg gcgcggagag tacgtgctgc tggaggcagc gctgaccgac     1440

ctgagggtgc aggcgcgggc ccagcccggg acgatgtcca acggcacgga gacccgtggc     1500

actgggctga ccgcagtggc cgtccaggag ggcaactcag atgtggtgga agtcaggctg     1560

gccaacagga ccggaggtct ggaggtgctg ctgaaccagg aggtgctgag cttcaccgag     1620

cagagctgga tggacctgaa aggaatgttc ctgtcggtgg ctgccgggga cagggtctcc     1680

atcatgctgg catcaggggc cggcctggag gtcagcgtgc agggcccgtt cctgagtgtg     1740

tccgtcctgc tgcctgagaa gttcctcacc cacacccacg gcctcctcgg gacactcaac     1800

aacgacccca ccgacgactt caccctgcac agcgggcgcg tcctgccccc aggcaccagt     1860

ccccaggagc tgttcctgtt tggggccaac tggaccgtgc acaatgcgtc ctccctgctc     1920

acctacgatt cctggttcct ggtccacaac ttcctgtacc aacccaagca cgaccccacc     1980

ttcgagcccc tcttccccag tgagaccacc ctcaacccca gcctggcaca agaggcagcc     2040

aaactatgtg gggacgatca tttctgcaac tttgatgtgg cagccactgg gagcctgagc     2100

acgggcactg ccactcgggt ggcccaccag ctgcaccagc gtcgcatgca gagcctgcag     2160

ccagtggtgt cctgtggctg gctggcccca cctcccaacg gacaaaagga gggcaacagg     2220

tacctggcgg gttccaccat ctacttccac tgtgacaacg gctacagcct ggccggggca     2280

gagaccagca cctgccaggc tgacggcacc tggtcctcac ccaccccgaa gtgccagcca     2340

ggacgcagct acgcggtgct gttgggcatc atctttgggg gcctcgcggt ggtggcggcg     2400

gttgcgctcg tctatgtgct gctgcgccgc aggaagggca acacgcacgt ctggggtgca     2460

cagccctga                                                             2469


<210>  462
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Lys Pro Ala Leu Leu Pro Trp Ala Leu Leu Leu Leu Ala Thr Ala 
1               5                   10                  15      


Leu Gly Pro Gly Pro Gly Pro Thr Ala Asp Ala Gln Glu Ser Cys Ser 
            20                  25                  30          


Met Arg Cys Gly Ala Leu Asp Gly Pro Cys Ser Cys His Pro Thr Cys 
        35                  40                  45              


Ser Gly Leu Gly Thr Cys Cys Leu Asp Phe Arg Asp Phe Cys Leu Glu 
    50                  55                  60                  


Ile Leu Pro Tyr Ser Gly Ser Met Met Gly Gly Lys Asp Phe Val Val 
65                  70                  75                  80  


Arg His Phe Lys Met Ser Ser Pro Thr Asp Ala Ser Val Ile Cys Arg 
                85                  90                  95      


Phe Lys Asp Ser Ile Gln Thr Leu Gly His Val Asp Ser Ser Gly Gln 
            100                 105                 110         


Val His Cys Val Ser Pro Leu Leu Tyr Glu Ser Gly Arg Ile Pro Phe 
        115                 120                 125             


Thr Val Ser Leu Asp Asn Gly His Ser Phe Pro Arg Ala Gly Thr Trp 
    130                 135                 140                 


Leu Ala Val His Pro Asn Lys Val Ser Met Met Glu Lys Ser Glu Leu 
145                 150                 155                 160 


Val Asn Glu Thr Arg Trp Gln Tyr Tyr Gly Thr Ala Asn Thr Ser Gly 
                165                 170                 175     


Asn Leu Ser Leu Thr Trp His Val Lys Ser Leu Pro Thr Gln Thr Ile 
            180                 185                 190         


Thr Ile Glu Leu Trp Gly Tyr Glu Glu Thr Gly Met Pro Tyr Ser Gln 
        195                 200                 205             


Glu Trp Thr Ala Lys Trp Ser Tyr Leu Tyr Pro Leu Ala Thr His Ile 
    210                 215                 220                 


Pro Asn Ser Gly Ser Phe Thr Phe Thr Pro Lys Pro Ala Pro Pro Ser 
225                 230                 235                 240 


Tyr Gln Arg Trp Arg Val Gly Ala Leu Arg Ile Ile Asp Ser Lys Asn 
                245                 250                 255     


Tyr Ala Gly Gln Lys Asp Val Gln Ala Leu Trp Thr Asn Asp His Ala 
            260                 265                 270         


Leu Ala Trp His Leu Ser Asp Asp Phe Arg Glu Asp Pro Val Ala Trp 
        275                 280                 285             


Ala Arg Thr Gln Cys Gln Ala Trp Glu Glu Leu Glu Asp Gln Leu Pro 
    290                 295                 300                 


Asn Phe Leu Glu Glu Leu Pro Asp Cys Pro Cys Thr Leu Thr Gln Ala 
305                 310                 315                 320 


Arg Ala Asp Ser Gly Arg Phe Phe Thr Asp Tyr Gly Cys Asp Met Glu 
                325                 330                 335     


Gln Gly Ser Val Cys Thr Tyr His Pro Gly Ala Val His Cys Val Arg 
            340                 345                 350         


Ser Val Gln Ala Ser Leu Arg Tyr Gly Ser Gly Gln Gln Cys Cys Tyr 
        355                 360                 365             


Thr Ala Asp Gly Thr Gln Leu Leu Thr Ala Asp Ser Ser Gly Gly Ser 
    370                 375                 380                 


Thr Pro Asp Arg Gly His Asp Trp Gly Ala Pro Pro Phe Arg Thr Pro 
385                 390                 395                 400 


Pro Arg Val Pro Ser Met Ser His Trp Leu Tyr Asp Val Leu Ser Phe 
                405                 410                 415     


Tyr Tyr Cys Cys Leu Trp Ala Pro Asp Cys Pro Arg Tyr Met Gln Arg 
            420                 425                 430         


Arg Pro Ser Asn Asp Cys Arg Asn Tyr Arg Pro Pro Arg Leu Ala Ser 
        435                 440                 445             


Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp Gly Thr Asn Phe Thr 
    450                 455                 460                 


Phe Asn Gly Arg Gly Glu Tyr Val Leu Leu Glu Ala Ala Leu Thr Asp 
465                 470                 475                 480 


Leu Arg Val Gln Ala Arg Ala Gln Pro Gly Thr Met Ser Asn Gly Thr 
                485                 490                 495     


Glu Thr Arg Gly Thr Gly Leu Thr Ala Val Ala Val Gln Glu Gly Asn 
            500                 505                 510         


Ser Asp Val Val Glu Val Arg Leu Ala Asn Arg Thr Gly Gly Leu Glu 
        515                 520                 525             


Val Leu Leu Asn Gln Glu Val Leu Ser Phe Thr Glu Gln Ser Trp Met 
    530                 535                 540                 


Asp Leu Lys Gly Met Phe Leu Ser Val Ala Ala Gly Asp Arg Val Ser 
545                 550                 555                 560 


Ile Met Leu Ala Ser Gly Ala Gly Leu Glu Val Ser Val Gln Gly Pro 
                565                 570                 575     


Phe Leu Ser Val Ser Val Leu Leu Pro Glu Lys Phe Leu Thr His Thr 
            580                 585                 590         


His Gly Leu Leu Gly Thr Leu Asn Asn Asp Pro Thr Asp Asp Phe Thr 
        595                 600                 605             


Leu His Ser Gly Arg Val Leu Pro Pro Gly Thr Ser Pro Gln Glu Leu 
    610                 615                 620                 


Phe Leu Phe Gly Ala Asn Trp Thr Val His Asn Ala Ser Ser Leu Leu 
625                 630                 635                 640 


Thr Tyr Asp Ser Trp Phe Leu Val His Asn Phe Leu Tyr Gln Pro Lys 
                645                 650                 655     


His Asp Pro Thr Phe Glu Pro Leu Phe Pro Ser Glu Thr Thr Leu Asn 
            660                 665                 670         


Pro Ser Leu Ala Gln Glu Ala Ala Lys Leu Cys Gly Asp Asp His Phe 
        675                 680                 685             


Cys Asn Phe Asp Val Ala Ala Thr Gly Ser Leu Ser Thr Gly Thr Ala 
    690                 695                 700                 


Thr Arg Val Ala His Gln Leu His Gln Arg Arg Met Gln Ser Leu Gln 
705                 710                 715                 720 


Pro Val Val Ser Cys Gly Trp Leu Ala Pro Pro Pro Asn Gly Gln Lys 
                725                 730                 735     


Glu Gly Asn Arg Tyr Leu Ala Gly Ser Thr Ile Tyr Phe His Cys Asp 
            740                 745                 750         


Asn Gly Tyr Ser Leu Ala Gly Ala Glu Thr Ser Thr Cys Gln Ala Asp 
        755                 760                 765             


Gly Thr Trp Ser Ser Pro Thr Pro Lys Cys Gln Pro Gly Arg Ser Tyr 
    770                 775                 780                 


Ala Val Leu Leu Gly Ile Ile Phe Gly Gly Leu Ala Val Val Ala Ala 
785                 790                 795                 800 


Val Ala Leu Val Tyr Val Leu Leu Arg Arg Arg Lys Gly Asn Thr His 
                805                 810                 815     


Val Trp Gly Ala Gln Pro 
            820         


<210>  463
<211>  2952
<212>  DNA
<213>  Homo sapiens

<400>  463
atggattgtc agctctccat cctcctcctt ctcagctgct ctgttctcga cagcttcggg       60

gaactgattc cgcagccttc caatgaagtc aatctactgg attcaaaaac aattcaaggg      120

gagctgggct ggatctctta tccatcacat gggtgggaag agatcagtgg tgtggatgaa      180

cattacacac ccatcaggac ttaccaggtg tgcaatgtca tggaccacag tcaaaacaat      240

tggctgagaa caaactgggt ccccaggaac tcagctcaga agatttatgt ggagctcaag      300

ttcactctac gagactgcaa tagcattcca ttggttttag gaacttgcaa ggagacattc      360

aacctgtact acatggagtc tgatgatgat catggggtga aatttcgaga gcatcagttt      420

acaaagattg acaccattgc agctgatgaa agtttcactc aaatggatct tggggaccgt      480

attctgaagc tcaacactga gattagagaa gtaggtcctg tcaacaagaa gggattttat      540

ttggcatttc aagatgttgg tgcttgtgtt gccttggtgt ctgtgagagt atacttcaaa      600

aagtgcccat ttacagtgaa gaatctggct atgtttccag acacggtacc catggactcc      660

cagtccctgg tggaggttag agggtcttgt gtcaacaatt ctaaggagga agatcctcca      720

aggatgtact gcagtacaga aggcgaatgg cttgtaccca ttggcaagtg ttcctgcaat      780

gctggctatg aagaaagagg ttttatgtgc caagcttgtc gaccaggttt ctacaaggca      840

ttggatggta atatgaagtg tgctaagtgc ccgcctcaca gttctactca ggaagatggt      900

tcaatgaact gcaggtgtga gaataattac ttccgggcag acaaagaccc tccatccatg      960

gcttgtaccc gacctccatc ttcaccaaga aatgttatct ctaatataaa cgagacctca     1020

gttatcctgg actggagttg gcccctggac acaggaggcc ggaaagatgt taccttcaac     1080

atcatatgta aaaaatgtgg gtggaatata aaacagtgtg agccatgcag cccaaatgtc     1140

cgcttcctcc ctcgacagtt tggactcacc aacaccacgg tgacagtgac agaccttctg     1200

gcacatacta actacacctt tgagattgat gccgttaatg gggtgtcaga gctgagctcc     1260

ccaccaagac agtttgctgc ggtcagcatc acaactaatc aggctgctcc atcacctgtc     1320

ctgacgatta agaaagatcg gacctccaga aatagcatct ctttgtcctg gcaagaacct     1380

gaacatccta atgggatcat attggactac gaggtcaaat actatgaaaa gcaggaacaa     1440

gaaacaagtt ataccattct gagggcaaga ggcacaaatg ttaccatcag tagcctcaag     1500

cctgacacta tatacgtatt ccaaatccga gcccgaacag ccgctggata tgggacgaac     1560

agccgcaagt ttgagtttga aactagtcca gactctttct ccatctctgg tgaaagtagc     1620

caagtggtca tgatcgccat ttcagcggca gtagcaatta ttctcctcac tgttgtcatc     1680

tatgttttga ttgggaggtt ctgtggctat aagtcaaaac atggggcaga tgaaaaaaga     1740

cttcattttg gcaatgggca tttaaaactt ccaggtctca ggacttatgt tgacccacat     1800

acatatgaag accctaccca agctgttcat gagtttgcca aggaattgga tgccaccaac     1860

atatccattg ataaagttgt tggagcaggt gaatttggag aggtgtgcag tggtcgctta     1920

aaacttcctt caaaaaaaga gatttcagtg gccattaaga ccctgaaagt tggctacaca     1980

gaaaagcaga ggagagactt cctgggagaa gcaagcatta tgggacagtt tgaccacccc     2040

aatatcattc gactggaagg agttgttacc aaaagtaagc cagttatgat tgtcacagaa     2100

tacatggaga atggttcctt ggatagtttc ctacgtaaac acgatgccca gtttactgtc     2160

attcagctag tggggatgct tcgagggata gcatctggca tgaagtacct gtcagacatg     2220

ggctatgttc accgagacct cgctgctcgg aacatcttga tcaacagtaa cttggtgtgt     2280

aaggtttctg atttcggact ttcgcgtgtc ctggaggatg acccagaagc tgcttataca     2340

acaagaggag ggaagatccc aatcaggtgg acatcaccag aagctatagc ctaccgcaag     2400

ttcacgtcag ccagcgatgt atggagttat gggattgttc tctgggaggt gatgtcttat     2460

ggagagagac catactggga gatgtccaat caggatgtaa ttaaagctgt agatgagggc     2520

tatcgactgc caccccccat ggactgccca gctgccttgt atcagctgat gctggactgc     2580

tggcagaaag acaggaacaa cagacccaag tttgagcaga ttgttagtat tctggacaag     2640

cttatccgga atcccggcag cctgaagatc atcaccagtg cagccgcaag gccatcaaac     2700

cttcttctgg accaaagcaa tgtggatatc actaccttcc gcacaacagg tgactggctt     2760

aatggtgtct ggacagcaca ctgcaaggaa atcttcacgg gtgtggagta cagttcttgt     2820

gacacaatag ccaagatttc cacagatgac atgaaaaagg ttggtgtcac cgtggttggg     2880

ccacagaaga agatcatcag tagcattaaa gctctagaaa cgcaatcaaa gaatggccca     2940

gttcccgtgt aa                                                         2952


<210>  464
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  465
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  465
atgtctgaca aacccgatat ggctgagatc gagaaattcg ataagccgaa actgaagaag       60

acagagacgc aagagaaaaa tccactgcct tccaaagaaa cgattgaaca ggagaagcaa      120

gcaggcgaat cgtaa                                                       135


<210>  466
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Pro 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210>  467
<211>  2763
<212>  DNA
<213>  Homo sapiens

<400>  467
atgtctgacc cccacagcag tcctctcctg ccagagccac tttccagcag atacaaactc       60

tacgaggcag agtttaccag cccgagctgg ccctcgacat ccccggatac tcacccagct      120

ctgcccctcc tggaaatgcc tgaagaaaag gatctccggt cttccaatga agacagtcac      180

attgtgaaga tcgaaaagct caatgaaagg agtaaaagga aagacgacgg ggtggcccat      240

cgggactcag caggccaaag gtgcatctgc ctctccaaag cagtgggcta cctcacgggc      300

gacatgaagg agtacaggat ctggctgaaa gacaagcacc ttgccctcca gttcatagac      360

tgggtcctga gagggaccgc tcaggtgatg ttcatcaaca atcctctcag cggcctcatc      420

atcttcatag ggctgctgat ccagaatccc tggtggacaa tcactggggg cctggggaca      480

gtggtctcga ccttaacagc tctcgccttg ggccaagaca ggtctgccat tgcctcagga      540

ctccatgggt acaacgggat gctggtggga ctgctgatgg ccgtgttctc ggagaagtta      600

gactactact ggtggcttct gtttcctgtg accttcacag ccatgtcctg cccagttctt      660

tctagtgcct tgaattccat cttcagcaag tgggacctcc cggtcttcac tctgcccttc      720

aacattgcag tcaccttgta ccttgcagcc acaggccact acaacctctt cttccccaca      780

acactggtag agcctgtgtc ttcagtgccc aatatcacct ggacagagat ggaaatgccc      840

ctgctgttac aagccatccc tgttggggtc ggccaggtgt atggctgtga caatccctgg      900

acaggcggcg tgttcctggt ggctctgttc atctcctcgc cactcatctg cttgcatgca      960

gccattggct caatcgtggg gctgctagca gccctgtcag tggccacacc cttcgagacc     1020

atctacacag gcctctggag ctacaactgc gtcctctcct gcatcgccat cggaggcatg     1080

ttctatgccc tcacctggca gactcacctg ctggccctca tctgtgccct gttctgtgca     1140

tacatggaag cagccatctc caacatcatg tcagtggtgg gcgtgccacc aggcacctgg     1200

gccttctgcc ttgccaccat catcttcctg ctcctgacga caaacaaccc agccatcttc     1260

agactcccac tcagcaaagt cacctacccc gaggccaacc gcatctacta cctgacagtg     1320

aaaagcggtg aagaagagaa ggcccccagc ggaggcggtg gggagcatcc acccacagca     1380

ggcccaaagg tggaggaggg ctcggaggct gtgctctcca agcacaggag tgtatttcac     1440

atcgagtggt catccattcg gaggaggagc aaagtgtttg gaaaaggcga acaccaggaa     1500

agacaaaaca aagacccatt tccctatcga taccggaagc ccacagtcga gctgcttgat     1560

ctggacacca tggaggagag ctctgagata aaagtggaaa caaacatttc caagacatcc     1620

tggattcgga gttccatggc tgccagtggg aaaagggtca gcaaagccct cagctacatc     1680

acaggagaga tgaaggagtg tggagaggga cttaaagaca agtccccagt gttccagttc     1740

tttgactggg tcctccgagg cacatctcaa gtgatgtttg tgaacaaccc cctcagcggc     1800

atcctcatca tcctcggcct cttcatccag aacccctggt gggcgatctc aggctgcctg     1860

ggtaccatca tgtccacctt gacagccctc atcctgagtc aggacaagtc ggccatcgct     1920

gcaggatttc acggctacaa tggggtgctg gtggggctgc tgatggccgt gttctcagac     1980

aaaggtgact actactggtg gctgttgcta cccgtcatca tcatgtccat gtcttgcccc     2040

atcctctcca gtgccctggg taccatcttc agcaagtggg acctcccagt cttcacactg     2100

cccttcaata tcactgtgac tttgtacctg gcagccacgg gccactacaa ccttttcttc     2160

cccacaacgc tgctgcagcc tgcatccgcc atgcccaaca tcacctggtc agaggtccaa     2220

gtgcccttgc ttttgagagc catccccgtt ggaattggcc aagtgtacgg ctgtgataac     2280

ccctggactg gaggcatctt cctcatagct ctgttcatat cctcacctct catttgcttg     2340

catgcagcaa ttggatccac catggggatg ctagcagcac tcactattgc gacgcccttt     2400

gactccatct acttcggcct gtgtggcttc aacagcaccc tcgcatgcat agcgatagga     2460

ggcatgttct acgtcatcac ctggcagacg cacctcctcg ccatcgcctg cgcactgttt     2520

gctgcctacc tgggtgctgc cctggctaac atgttatctg tgtttggatt gccgccctgc     2580

acttggccct tctgtctctc agctctcacc ttcctgctcc tgacgaccaa taaccccgcc     2640

atctacaagc tcccgctcag caaagtcacc tacccagagg ccaaccgcat ctactacctg     2700

tcccaggaga gaaacagaag ggcatcaatc ataacaaagt atcaggccta cgatgtctcc     2760

taa                                                                   2763


<210>  468
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Ser Asp Pro His Ser Ser Pro Leu Leu Pro Glu Pro Leu Ser Ser 
1               5                   10                  15      


Arg Tyr Lys Leu Tyr Glu Ala Glu Phe Thr Ser Pro Ser Trp Pro Ser 
            20                  25                  30          


Thr Ser Pro Asp Thr His Pro Ala Leu Pro Leu Leu Glu Met Pro Glu 
        35                  40                  45              


Glu Lys Asp Leu Arg Ser Ser Asn Glu Asp Ser His Ile Val Lys Ile 
    50                  55                  60                  


Glu Lys Leu Asn Glu Arg Ser Lys Arg Lys Asp Asp Gly Val Ala His 
65                  70                  75                  80  


Arg Asp Ser Ala Gly Gln Arg Cys Ile Cys Leu Ser Lys Ala Val Gly 
                85                  90                  95      


Tyr Leu Thr Gly Asp Met Lys Glu Tyr Arg Ile Trp Leu Lys Asp Lys 
            100                 105                 110         


His Leu Ala Leu Gln Phe Ile Asp Trp Val Leu Arg Gly Thr Ala Gln 
        115                 120                 125             


Val Met Phe Val Asn Asn Pro Leu Ser Gly Leu Ile Ile Phe Ile Gly 
    130                 135                 140                 


Leu Leu Ile Gln Asn Pro Trp Trp Thr Ile Thr Gly Gly Leu Gly Thr 
145                 150                 155                 160 


Val Val Ser Thr Leu Thr Ala Leu Ala Leu Gly Gln Asp Arg Ser Ala 
                165                 170                 175     


Ile Ala Ser Gly Leu His Gly Tyr Asn Gly Met Leu Val Gly Leu Leu 
            180                 185                 190         


Met Ala Ala Phe Ser Glu Lys Leu Asp Tyr Tyr Trp Trp Leu Leu Phe 
        195                 200                 205             


Pro Val Thr Phe Thr Ala Met Ser Cys Pro Val Leu Ser Ser Ala Leu 
    210                 215                 220                 


Asn Ser Ile Phe Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe 
225                 230                 235                 240 


Asn Ile Ala Val Thr Leu Tyr Leu Ala Ala Thr Gly His Tyr Asn Leu 
                245                 250                 255     


Phe Phe Pro Thr Thr Leu Val Glu Pro Val Ser Ser Val Pro Asn Ile 
            260                 265                 270         


Thr Trp Thr Glu Met Glu Met Pro Leu Leu Leu Gln Ala Ile Pro Val 
        275                 280                 285             


Gly Val Gly Gln Val Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Val 
    290                 295                 300                 


Phe Leu Val Ala Leu Phe Ile Ser Ser Pro Leu Ile Cys Leu His Ala 
305                 310                 315                 320 


Ala Ile Gly Ser Ile Val Gly Leu Leu Ala Ala Leu Ser Val Ala Thr 
                325                 330                 335     


Pro Phe Glu Thr Ile Tyr Thr Gly Leu Trp Ser Tyr Asn Cys Val Leu 
            340                 345                 350         


Ser Cys Ile Ala Ile Gly Gly Met Phe Tyr Ala Leu Thr Trp Gln Thr 
        355                 360                 365             


His Leu Leu Ala Leu Ile Cys Ala Leu Phe Cys Ala Tyr Met Glu Ala 
    370                 375                 380                 


Ala Ile Ser Asn Ile Met Ser Val Val Gly Val Pro Pro Gly Thr Trp 
385                 390                 395                 400 


Ala Phe Cys Leu Ala Thr Ile Ile Phe Leu Leu Leu Thr Thr Asn Asn 
                405                 410                 415     


Pro Ala Ile Phe Arg Leu Pro Leu Ser Lys Val Thr Tyr Pro Glu Ala 
            420                 425                 430         


Asn Arg Ile Tyr Tyr Leu Thr Val Lys Ser Gly Glu Glu Glu Lys Ala 
        435                 440                 445             


Pro Ser Gly Gly Gly Gly Glu His Pro Pro Thr Ala Gly Pro Lys Val 
    450                 455                 460                 


Glu Glu Gly Ser Glu Ala Val Leu Ser Lys His Arg Ser Val Phe His 
465                 470                 475                 480 


Ile Glu Trp Ser Ser Ile Arg Arg Arg Ser Lys Val Phe Gly Lys Gly 
                485                 490                 495     


Glu His Gln Glu Arg Gln Asn Lys Asp Pro Phe Pro Tyr Gln Tyr Arg 
            500                 505                 510         


Lys Pro Thr Val Glu Leu Leu Asp Leu Asp Thr Met Glu Glu Ser Ser 
        515                 520                 525             


Glu Ile Lys Val Glu Thr Asn Ile Ser Lys Thr Ser Trp Ile Arg Ser 
    530                 535                 540                 


Ser Met Ala Ala Ser Gly Lys Arg Val Ser Lys Ala Leu Ser Tyr Ile 
545                 550                 555                 560 


Thr Gly Glu Met Lys Glu Cys Gly Glu Gly Leu Lys Asp Lys Ser Pro 
                565                 570                 575     


Val Phe Gln Phe Phe Asp Trp Val Leu Arg Gly Thr Ser Gln Val Met 
            580                 585                 590         


Phe Val Asn Asn Pro Leu Ser Gly Ile Leu Ile Ile Leu Gly Leu Phe 
        595                 600                 605             


Ile Gln Asn Pro Trp Trp Ala Ile Ser Gly Cys Leu Gly Thr Ile Met 
    610                 615                 620                 


Ser Thr Leu Thr Ala Leu Ile Leu Ser Gln Asp Lys Ser Ala Ile Ala 
625                 630                 635                 640 


Ala Gly Phe His Gly Tyr Asn Gly Val Leu Val Gly Leu Leu Met Ala 
                645                 650                 655     


Val Phe Ser Asp Lys Gly Asp Tyr Tyr Trp Trp Leu Leu Leu Pro Val 
            660                 665                 670         


Ile Ile Met Ser Met Ser Cys Pro Ile Leu Ser Ser Ala Leu Gly Thr 
        675                 680                 685             


Ile Phe Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe Asn Ile 
    690                 695                 700                 


Thr Val Thr Leu Tyr Leu Ala Ala Thr Gly His Tyr Asn Leu Phe Phe 
705                 710                 715                 720 


Pro Thr Thr Leu Leu Gln Pro Ala Ser Ala Met Pro Asn Ile Thr Trp 
                725                 730                 735     


Ser Glu Val Gln Val Pro Leu Leu Leu Arg Ala Ile Pro Val Gly Ile 
            740                 745                 750         


Gly Gln Val Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Ile Phe Leu 
        755                 760                 765             


Ile Ala Leu Phe Ile Ser Ser Pro Leu Ile Cys Leu His Ala Ala Ile 
    770                 775                 780                 


Gly Ser Thr Met Gly Met Leu Ala Ala Leu Thr Ile Ala Thr Pro Phe 
785                 790                 795                 800 


Asp Ser Ile Tyr Phe Gly Leu Cys Gly Phe Asn Ser Thr Leu Ala Cys 
                805                 810                 815     


Ile Ala Ile Gly Gly Met Phe Tyr Val Ile Thr Trp Gln Thr His Leu 
            820                 825                 830         


Leu Ala Ile Ala Cys Ala Leu Phe Ala Ala Tyr Leu Gly Ala Ala Leu 
        835                 840                 845             


Ala Asn Met Leu Ser Val Phe Gly Leu Pro Pro Cys Thr Trp Pro Phe 
    850                 855                 860                 


Cys Leu Ser Ala Leu Thr Phe Leu Leu Leu Thr Thr Asn Asn Pro Ala 
865                 870                 875                 880 


Ile Tyr Lys Leu Pro Leu Ser Lys Val Thr Tyr Pro Glu Ala Asn Arg 
                885                 890                 895     


Ile Tyr Tyr Leu Ser Gln Glu Arg Asn Arg Arg Ala Ser Ile Ile Thr 
            900                 905                 910         


Lys Tyr Gln Ala Tyr Asp Val Ser 
        915                 920 


<210>  469
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  469
atgggctacg ccaggaaagt aggctgggtg accgcaggcc tggtgattgg ggctggcgcc       60

tgctattgca tttatagact gactagggga agaaaacaga acaaggaaaa aatggctgag      120

ggtggatctg gggatgtgga tgatgctggg gactgttctg gggccaggta taatgactgg      180

tctgatgatg atgatgacag caatgagagc aagagtatag tatggtaccc accttgggct      240

cggattggga ctgaagctgg aaccagagct agggccaggg caagggccag ggctacccgg      300

gcacgtcggg ctgtccagaa acgggcttcc cccaattcag atgataccgt tttgtcccct      360

caagagctac aaaaggttct ttgcttggtt gagatgtctg aaaagcctta tattcttgaa      420

gcagctttaa ttgctctggg taacaatgct gcttatgcat ttaacagaga tattattcgt      480

gatctgggtg gtctcccaat tgtcgcaaag attctcaata ctcgggatcc catagttaag      540

gaaaaggctt taattgtcct gaataacttg agtgtgaatg ctgaaaatca gcgcaggctt      600

aaagtataca tgaatcaagt gtgtgatgac acaatcactt ctcgcttgaa ctcatctgtg      660

cagcttgctg gactgagatt gcttacaaat atgactgtta ctaatgagta tcagcacatg      720

cttgctaatt ccatttctga cttttttcgt ttattttcag cgggaaatga agaaaccaaa      780

cttcaggttc tgaaactcct tttgaatttg gctgaaaatc cagccatgac tagggaactg      840

ctcagggccc aagtaccatc ttcactgggc tccctcttta ataagaagga gaacaaagaa      900

gttattctta aacttctggt catatttgag aacataaatg ataatttcaa atgggaagaa      960

aatgaaccta ctcagaatca attcggtgaa ggttcacttt ttttcttttt aaaagaattt     1020

caagtgtgtg ctgataaggt tctgggaata gaaagtcacc atgatttttt ggtgaaagta     1080

aaagttggaa aattcatggc caaacttgct gaacatatgt tcccaaagag ccaggaataa     1140


<210>  470
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys 
            20                  25                  30          


Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp 
        35                  40                  45              


Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp 
    50                  55                  60                  


Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala 
65                  70                  75                  80  


Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys 
        115                 120                 125             


Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile 
    130                 135                 140                 


Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg 
145                 150                 155                 160 


Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp 
                165                 170                 175     


Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val 
            180                 185                 190         


Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys 
        195                 200                 205             


Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly 
    210                 215                 220                 


Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met 
225                 230                 235                 240 


Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn 
                245                 250                 255     


Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu 
            260                 265                 270         


Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser 
        275                 280                 285             


Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys 
    290                 295                 300                 


Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu 
305                 310                 315                 320 


Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe 
                325                 330                 335     


Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser 
            340                 345                 350         


His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys 
        355                 360                 365             


Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu 
    370                 375                 


<210>  471
<211>  3513
<212>  DNA
<213>  Homo sapiens

<400>  471
atggggctgg cctggggact aggcgtcctg ttcctgatgc atgtgtgtgg caccaaccgc       60

attccagagt ctggcggaga caacagcgtg tttgacatct ttgaactcac cggggccgcc      120

cgcaaggggt ctgggcgccg actggtgaag ggccccgacc cttccagccc agctttccgc      180

atcgaggatg ccaacctgat cccccctgtg cctgatgaca agttccaaga cctggtggat      240

gctgtgcggg cagaaaaggg tttcctcctt ctggcatccc tgaggcagat gaagaagacc      300

cggggcacgc tgctggccct ggagcggaaa gaccactctg gccaggtctt cagcgtggtg      360

tccaatggca aggcgggcac cctggacctc agcctgaccg tccaaggaaa gcagcacgtg      420

gtgtctgtgg aagaagctct cctggcaacc ggccagtgga agagcatcac cctgtttgtg      480

caggaagaca gggcccagct gtacatcgac tgtgaaaaga tggagaatgc tgagttggac      540

gtccccatcc aaagcgtctt caccagagac ctggccagca tcgccagact ccgcatcgca      600

aaggggggcg tcaatgacaa tttccagggg gtgctgcaga atgtgaggtt tgtctttgga      660

accacaccag aagacatcct caggaacaaa ggctgctcca gctctaccag tgtcctcctc      720

acccttgaca acaacgtggt gaatggttcc agccctgcca tccgcactaa ctacattggc      780

cacaagacaa aggacttgca agccatctgc ggcatctcct gtgatgagct gtccagcatg      840

gtcctggaac tcaggggcct gcgcaccatt gtgaccacgc tgcaggacag catccgcaaa      900

gtgactgaag agaacaaaga gttggccaat gagctgaggc ggcctcccct atgctatcac      960

aacggagttc agtacagaaa taacgaggaa tggactgttg atagctgcac tgagtgtcac     1020

tgtcagaact cagttaccat ctgcaaaaag gtgtcctgcc ccatcatgcc ctgctccaat     1080

gccacagttc ctgatggaga atgctgtcct cgctgttggc ccagcgactc tgcggacgat     1140

ggctggtctc catggtccga gtggacctcc tgttctacga gctgtggcaa tggaattcag     1200

cagcgcggcc gctcctgcga tagcctcaac aaccgatgtg agggctcctc ggtccagaca     1260

cggacctgcc acattcagga gtgtgacaag agatttaaac aggatggtgg ctggagccac     1320

tggtccccgt ggtcatcttg ttctgtgaca tgtggtgatg gtgtgatcac aaggatccgg     1380

ctctgcaact ctcccagccc ccagatgaac gggaaaccct gtgaaggcga agcgcgggag     1440

accaaagcct gcaagaaaga cgcctgcccc atcaatggag gctggggtcc ttggtcacca     1500

tgggacatct gttctgtcac ctgtggagga ggggtacaga aacgtagtcg tctctgcaac     1560

aaccccacac cccagtttgg aggcaaggac tgcgttggtg atgtaacaga aaaccagatc     1620

tgcaacaagc aggactgtcc aattgatgga tgcctgtcca atccctgctt tgccggcgtg     1680

aagtgtacta gctaccctga tggcagctgg aaatgtggtg cttgtccccc tggttacagt     1740

ggaaatggca tccagtgcac agatgttgat gagtgcaaag aagtgcctga tgcctgcttc     1800

aaccacaatg gagagcaccg gtgtgagaac acggaccccg gctacaactg cctgccctgc     1860

cccccacgct tcaccggctc acagcccttc ggccagggtg tcgaacatgc cacggccaac     1920

aaacaggtgt gcaagccccg taacccctgc acggatggga cccacgactg caacaagaac     1980

gccaagtgca actacctggg ccactatagc gaccccatgt accgctgcga gtgcaagcct     2040

ggctacgctg gcaatggcat catctgcggg gaggacacag acctggatgg ctggcccaat     2100

gagaacctgg tgtgcgtggc caatgcgact taccactgca aaaaggataa ttgccccaac     2160

cttcccaact cagggcagga agactatgac aaggatggaa ttggtgatgc ctgtgatgat     2220

gacgatgaca atgataaaat tccagatgac agggacaact gtccattcca ttacaaccca     2280

gctcagtatg actatgacag agatgatgtg ggagaccgct gtgacaactg tccctacaac     2340

cacaacccag atcaggcaga cacagacaac aatggggaag gagacgcctg tgctgcagac     2400

attgatggag acggtatcct caatgaacgg gacaactgcc agtacgtcta caatgtggac     2460

cagagagaca ctgatatgga tggggttgga gatcagtgtg acaattgccc cttggaacac     2520

aatccggatc agctggactc tgactcagac cgcattggag atacctgtga caacaatcag     2580

gatattgatg aagatggcca ccagaacaat ctggacaact gtccctatgt gcccaatgcc     2640

aaccaggctg accatgacaa agatggcaag ggagatgcct gtgaccacga tgatgacaac     2700

gatggcattc ctgatgacaa ggacaactgc agactcgtgc ccaatcccga ccagaaggac     2760

tctgacggcg atggtcgagg tgatgcctgc aaagatgatt ttgaccatga cagtgtgcca     2820

gacatcgatg acatctgtcc tgagaatgtt gacatcagtg agaccgattt ccgccgattc     2880

cagatgattc ctctggaccc caaagggaca tcccaaaatg accctaactg ggttgtacgc     2940

catcagggta aagaactcgt ccagactgtc aactgtgatc ctggactcgc tgtaggttat     3000

gatgagttta atgctgtgga cttcagtggc accttcttca tcaacaccga aagggacgat     3060

gactatgctg gatttgtctt tggctaccag tccagcagcc gcttttatgt tgtgatgtgg     3120

aagcaagtca cccagtccta ctgggacacc aaccccacga gggctcaggg atactcgggc     3180

ctttctgtga aagttgtaaa ctccaccaca gggcctggcg agcacctgcg gaacgccctg     3240

tggcacacag gaaacacccc tggccaggtg cgcaccctgt ggcatgaccc tcgtcacata     3300

ggctggaaag atttcaccgc ctacagatgg cgtctcagcc acaggccaaa gacgggtttc     3360

attagagtgg tgatgtatga agggaagaaa atcatggctg actcaggacc catctatgat     3420

aaaacctatg ctggtggtag actagggttg tttgtcttct ctcaagaaat ggtgttcttc     3480

tctgacctga aatacgaatg tagagatccc taa                                  3513


<210>  472
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  473
<211>  7131
<212>  DNA
<213>  Homo sapiens

<400>  473
atgaatcttg actcgctctc gctggccttg tctcaaatca gctacctggt ggacaattta       60

accaagaaaa attaccgagc cagccagcag gaaatacagc atattgtgaa tcggcacggt      120

cctgaggcag acaggcattt attacgctgc ctattttcgc atgtggattt cagtggcgat      180

ggtaaaagca gtggcaaaga tttccatcag actcagtttc tgattcagga gtgtgcgttg      240

ctgattacaa agccaaattt tatctcgacg ctgtcctatg ccattgataa tccattgcac      300

tatcagaaga gtttaaagcc tgcaccccac ttatttgccc agctgagtaa agtgctcaaa      360

ttaagcaaag tacaagaggt aatttttggc cttgccctgt tgaattcttc cagctcagat      420

cttagaggtt tcgctgccca gtttatcaaa cagaagcttc cagatcttct gcgttcttac      480

attgacgcag acgtcagtgg aaatcaagaa ggtggcttcc aagatatagc aatagaggtc      540

ctacacctcc tcctctccca tctcctcttt gggcagaagg gagcctttgg agttggacaa      600

gaacagatag acgcttttct taagacgctg cgcagagatt ttccccaaga acgctgtccc      660

gtggtgctcg caccactttt ataccctgaa aaacgggaca ttctaatgga caggatcctg      720

cctgattccg gaggggtagc taaaaccatg atggagagct ctttggctga tttcatgcaa      780

gaagtaggct atggcttttg tgcaagtatt gaagaatgtc gcaatataat cgtgcagttt      840

ggtgttcggg aggtcacagc tgcccaggtt gcaagggttt tgggaatgat ggctcgaact      900

cattcaggat taacagatgg cattccatta cagagtattt ctgctccggg cagtgggatc      960

tggagtgatg ggaaagataa aagtgatgga gcacaggcac acacatggaa tgtagaagtc     1020

ttgattgacg ttcttaaaga actgaatcca agtttgaatt tcaaggaagt aacttatgaa     1080

ctggaccatc ctggatttca aattcgtgac agtaaaggac ttcataatgt ggtttatggc     1140

attcagaggg gtttgggtat ggaagtgttc ccagtagacc tcatatatag accttggaaa     1200

catgctgaag gccagctctc cttcattcaa cattccctta taaatccaga gatcttctgt     1260

tttgctgact atccctgtca tactgttgcc actgatattc tgaaagcacc accagaggat     1320

gacaatcgag aaattgccac atggaagagc ttggatttga ttgaatctct gctgaggctt     1380

gcagaggttg ggcagtatga gcaagtcaaa cagctcttca gcttccctat caaacactgt     1440

ccagacatgc tggtattggc cttactacaa attaacacct cttggcatac cttgcgccat     1500

gaacttatct ccactctgat gccaattttc cttggaaacc atcctaactc agctattatt     1560

ttgcactatg catggcatgg gcagggacag tctccctcaa ttcgccaact tatcatgcat     1620

gcaatggcag aatggtacat gagaggggag cagtatgatc aggccaaatt gtctcgaata     1680

cttgatgtgg cccaggactt gaaggccttg tcaatgctgc taaatggtac tccatttgcc     1740

tttgttattg accttgctgc acttgcttca cgtcgtgaat acctcaaact tgataagtgg     1800

ctcacagata aaattcgaga gcatggggag ccttttatcc aggcgtgtat gactttttta     1860

aagagacggt gtccttctat tttgggcgga cttgccccag aaaaagacca gcccaaaagt     1920

gctcaacttc ctccagaaac tttggcgaca atgttggcct gtctgcaagc ttgtgcaggg     1980

agtgtttctc aggagctatc agaaactatc ctcaccatgg tagccaattg cagtaatgtt     2040

atgaataagg ccagacaacc accacctgga gttatgccaa aaggacgtcc tcctagtgct     2100

agcagcttag atgccatttc tcctgttcag attgaccctc ttgctggaat gacatctctt     2160

agtataggtg gttcagctgc ccctcacacc cagagtatgc agggttttcc tccaaatttg     2220

ggttctgcat tcagtacccc tcagtcacca gcaaaagcat ttccacccct ttcaaccccc     2280

aatcagacca ctgcattcag tggtattgga ggactttcat cacagcttcc agtaggtggt     2340

cttggcacag gcagcctgac tggtatagga actggtgctc ttggactccc tgcagtgaat     2400

aacgaccctt ttgtacagag gaaactgggc acctctggac tgaatcagcc tacattccag     2460

cagagtaaga tgaaaccttc ggacttgtct caggtgtggc cagaggcaaa ccagcacttt     2520

agtaaagaga tagatgatga agcaaacagc tatttccagc gaatatataa tcatccacca     2580

catccaacca tgtctgttga tgaggtatta gaaatgctgc agagatttaa agactctact     2640

ataaagaggg aacgagaagt atttaactgt atgctaagga acttgtttga agaatatcgt     2700

ttttttcccc agtatcctga taaagagtta catataacag cctgcctatt tggtggtata     2760

attgagaaag gactggtcac ttacatggca ctaggtctgg ctctacgata tgttcttgaa     2820

gccttacgca agccttttgg atccaaaatg tattatttcg ggattgctgc actagataga     2880

tttaaaaaca gattgaagga ctatccccag tattgtcagc atttggcttc tatcagtcac     2940

tttatgcaat ttccacatca tttacaggag tatattgagt atggacagca gtctagagat     3000

cctcctgtga aaatgcaagg ctctatcaca acccctggaa gtattgcact ggctcaggcc     3060

caggctcagg cccaggttcc agcaaaagct cctcttgctg gtcaagttag cactatggta     3120

accacctcaa caactaccac tgttgctaaa acggttacgg tcaccaggcc aactggagtc     3180

agctttaaga aagatgtgcc accttctatt aatactacaa atatagatac gttgcttgtg     3240

gccacagatc aaactgagag aattgtggag cccccagaaa atatccagga gaaaattgct     3300

tttattttca ataatctctc acagtcaaat atgacacaaa aggttgaaga gctaaaggaa     3360

acggtgaaag aagaatttat gccttgggtt tcacagtatc tggttatgaa gagagtcagt     3420

attgagccaa actttcatag cctgtattca aacttccttg acacgctgaa gaatcctgaa     3480

tttaacaaga tggttctgaa tgagacctac agaaacatta aagtgctcct gacctctgat     3540

aaagctgcag ccaatttctc agatcgttct ttgctgaaga acttgggaca ttggctagga     3600

atgatcacat tagctaaaaa caaacccatc ttacacactg acttggatgt gaaatcattg     3660

ctgctagagg cttatgttaa aggacaacaa gaattgctct atgtagtgcc ctttgttgcc     3720

aaagtcttag aatctagcat tcgtagtgtg gtttttaggc caccaaaccc ttggacaatg     3780

gcaattatga atgtattagc tgagctacat caggagcatg acttaaagtt aaacttgaag     3840

tttgaaatcg aggttctctg caagaacctt gcattagaca tcaatgagct aaaacctgga     3900

aacctcctaa aggataaaga tcgcctgaag aatttagatg agcaactctc tgctccaaag     3960

aaagatgtca agcagccaga agaactccct cccatcacaa ccacaacaac ttctactaca     4020

ccagctacca acaccacttg tacagccacg gttccaccac agccacagta cagctaccac     4080

gacatcaatg tctattccct tgcgggcttg gcaccacaca ttactctgaa tccaacaatt     4140

cccttgtttc aggcccatcc acagttgaag cagtgtgtgc gtcaggcaat tgaacgggct     4200

gtccaggagc tggtccatcc tgtggtggat cgatcaatta agattgccat gactacttgt     4260

gagcaaatag tcaggaagga ttttgccctg gattcggagg aatctcgaat gcgaatagca     4320

gctcatcaca tgatgcgtaa cttgacagct ggaatggcta tgattacatg cagggaacct     4380

ttgctcatga gcatatctac caacttaaaa aacagttttg cctcagccct tcgtactgct     4440

tccccacaac aaagagaaat gatggatcag gcagctgctc aattagctca ggacaattgt     4500

gagttggctt gctgttttat tcagaagact gcagtagaaa aagcaggccc tgagatggac     4560

aagagattag caactgaatt tgagctgaga aaacatgcta ggcaagaagg acgcagatac     4620

tgtgatcctg ttgttttaac atatcaagct gaacggatgc cagagcaaat caggctgaaa     4680

gttggtggtg tggacccaaa gcagttggct gtttacgaag agtttgcacg caatgttcct     4740

ggcttcttac ctacaaatga cttaagtcag cccacgggat ttttagccca gcccatgaag     4800

caagcttggg caacagatga tgtagctcag atttatgata agtgtattac agaactggag     4860

caacatctac atgccatccc accaactttg gccatgaacc ctcaagctca ggctcttcga     4920

agtctcttgg aggttgtagt tttatctcga aactctcggg atgccatagc tgctcttgga     4980

ttgctccaaa aggctgtaga gggcttacta gatgccacaa gtggtgctga tgctgacctt     5040

ctgctgcgct acagggaatg ccacctcttg gtcctaaaag ctctgcagga tggccgggca     5100

tatgggtctc catggtgcaa caaacagatc acaaggtgcc taattgaatg tcgagatgaa     5160

tataaatata atgtggaggc tgtggagctg ctaattcgca atcatttggt taatatgcag     5220

cagtatgatc ttcacctagc gcagtcaatg gagaatggct taaactacat ggctgtggca     5280

tttgctatgc agttagtaaa aatcctgctg gtggatgaaa ggagtgttgc tcatgttact     5340

gaggcagatc tgttccacac cattgaaacc ctcatgagga ttaatgctca ttccagaggc     5400

aatgctccag aaggattgcc ccagctgatg gaagtagtgc gatccaacta tgaagcaatg     5460

attgatcgtg ctcatggagg cccaaacttt atgatgcatt ctgggatctc tcaagcctca     5520

gagtatgatg accctccagg cctgagggag aaggcagagt atcttctgag ggaatgggtg     5580

aatctctacc attcagcagc agctggccgc gacagtacca aagctttctc tgcatttgtt     5640

ggacagatgc accagcaagg aatactgaag accgatgatc tcataacaag gttctttcgt     5700

ctgtgtactg aaatgtgtgt tgaaatcagt taccgtgctc aggctgagca gcagcacaat     5760

cctgctgcca atcccaccat gatccgagcc aagtgctatc acaacctgga tgcctttgtt     5820

cgactcattg cactgctcgt gaaacactca ggggaggcca ccaacactgt cacaaagatt     5880

aatctgctga acaaggtcct tggtatagta gtgggagttc tccttcagga tcatgatgtt     5940

cgtcagagtg aatttcagca acttccctac catcgaattt ttatcatgct tctcttggaa     6000

ctcaatgcac ctgagcatgt gttggaaacc attaatttcc agacacttac agctttctgc     6060

aatacattcc acatcttgag gcctaccaaa gctcctggct ttgtatatgc ctggcttgaa     6120

ctgatttccc atcggatatt tattgcaaga atgctggcac atacgccaca gcagaagggg     6180

tggcctatgt atgcacagct actgattgat ttattcaaat atttagcgcc tttccttaga     6240

aatgtggaac tcaccaaacc tatgcaaatc ctctacaagg gcactttaag agtgctgctg     6300

gttcttttgc atgatttccc agagttcctt tgtgattacc attatgggtt ctgtgatgtg     6360

atcccaccta attgtatcca gttaagaaat ttgatcctga gtgcctttcc aagaaacatg     6420

aggctccccg acccattcac tcctaatcta aaggtggaca tgttgagtga aattaacatt     6480

gctccccgga ttctcaccaa tttcactgga gtaatgccac ctcagttcaa aaaggatttg     6540

gattcctatc ttaaaactcg atcaccagtc actttcctgt ctgatctgcg cagcaaccta     6600

caggtatcca atgaacctgg gaatcgctac aacctccagc tcatcaatgc actggtgctc     6660

tatgtcggga ctcaggccat tgcgcacatc cacaacaagg gcagcacacc ttcaatgagc     6720

accatcactc actcagcaca catggatatc ttccagaatt tggctgtgga cttggacact     6780

gagggtcgct atctcttttt gaatgcaatt gcaaatcagc tccggtaccc aaatagccac     6840

actcactact tcagttgcac catgctgtac ctttttgcag aggccaatac ggaagccatc     6900

caagaacaga tcacaagagt tctcttggaa cggttgattg taaataggcc acatccttgg     6960

ggtcttctta ttaccttcat tgagctgatt aaaaacccag cgtttaagtt ctggaaccat     7020

gaatttgtac actgtgcccc agaaatcgaa aagttattcc agtcggtcgc acagtgctgc     7080

atgggacaga agcaggccca gcaagtaatg gaagggacag gtgccagtta g              7131


<210>  474
<211>  2376
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Thr Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Thr Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Thr His Ser Gly Leu 
    290                 295                 300                 


Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Thr Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Thr Val Ala Thr Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Thr Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Thr Ser Trp His 
                485                 490                 495     


Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Thr Ile Leu Thr 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Thr Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr Thr Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Thr Gly 
    770                 775                 780                 


Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Thr Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val 
            820                 825                 830         


Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala 
        835                 840                 845             


Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Thr Met 
    850                 855                 860                 


Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Thr 
865                 870                 875                 880 


Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe 
                885                 890                 895     


Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile 
            900                 905                 910         


Thr Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Thr Tyr 
        915                 920                 925             


Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys 
    930                 935                 940                 


Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg 
945                 950                 955                 960 


Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala 
                965                 970                 975     


Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile 
            980                 985                 990         


Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val Lys Met  Gln Gly Ser 
        995                 1000                 1005             


Ile Thr  Thr Pro Gly Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala Gly Gln  Val Ser Thr 
    1025                 1030                 1035             


Met Val  Thr Thr Ser Thr Thr  Thr Thr Val Ala Lys  Thr Val Thr 
    1040                 1045                 1050             


Val Thr  Arg Pro Thr Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro 
    1055                 1060                 1065             


Ser Ile  Asn Thr Thr Asn Ile  Asp Thr Leu Leu Val  Ala Thr Asp 
    1070                 1075                 1080             


Gln Thr  Glu Arg Ile Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys 
    1085                 1090                 1095             


Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln Ser Asn  Met Thr Gln 
    1100                 1105                 1110             


Lys Val  Glu Glu Leu Lys Glu  Thr Val Lys Glu Glu  Phe Met Pro 
    1115                 1120                 1125             


Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg Val Ser  Ile Glu Pro 
    1130                 1135                 1140             


Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu Asp Thr  Leu Lys Asn 
    1145                 1150                 1155             


Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu Thr Tyr  Arg Asn Ile 
    1160                 1165                 1170             


Lys Val  Leu Leu Thr Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp 
    1175                 1180                 1185             


Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp Leu Gly  Met Ile Thr 
    1190                 1195                 1200             


Leu Ala  Lys Asn Lys Pro Ile  Leu His Thr Asp Leu  Asp Val Lys 
    1205                 1210                 1215             


Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu 
    1220                 1225                 1230             


Tyr Val  Val Pro Phe Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg 
    1235                 1240                 1245             


Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp Thr Met  Ala Ile Met 
    1250                 1255                 1260             


Asn Val  Leu Ala Glu Leu His  Gln Glu His Asp Leu  Lys Leu Asn 
    1265                 1270                 1275             


Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp 
    1280                 1285                 1290             


Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg 
    1295                 1300                 1305             


Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val 
    1310                 1315                 1320             


Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Thr Thr Thr  Thr Thr Ser 
    1325                 1330                 1335             


Thr Thr  Pro Ala Thr Asn Thr  Thr Cys Thr Ala Thr  Val Pro Pro 
    1340                 1345                 1350             


Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala 
    1355                 1360                 1365             


Gly Leu  Ala Pro His Ile Thr  Leu Asn Pro Thr Ile  Pro Leu Phe 
    1370                 1375                 1380             


Gln Ala  His Pro Gln Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu 
    1385                 1390                 1395             


Arg Ala  Val Gln Glu Leu Val  His Pro Val Val Asp  Arg Ser Ile 
    1400                 1405                 1410             


Lys Ile  Ala Met Thr Thr Cys  Glu Gln Ile Val Arg  Lys Asp Phe 
    1415                 1420                 1425             


Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg Ile Ala  Ala His His 
    1430                 1435                 1440             


Met Met  Arg Asn Leu Thr Ala  Gly Met Ala Met Ile  Thr Cys Arg 
    1445                 1450                 1455             


Glu Pro  Leu Leu Met Ser Ile  Ser Thr Asn Leu Lys  Asn Ser Phe 
    1460                 1465                 1470             


Ala Ser  Ala Leu Arg Thr Ala  Ser Pro Gln Gln Arg  Glu Met Met 
    1475                 1480                 1485             


Asp Gln  Ala Ala Ala Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala 
    1490                 1495                 1500             


Cys Cys  Phe Ile Gln Lys Thr  Ala Val Glu Lys Ala  Gly Pro Glu 
    1505                 1510                 1515             


Met Asp  Lys Arg Leu Ala Thr  Glu Phe Glu Leu Arg  Lys His Ala 
    1520                 1525                 1530             


Arg Gln  Glu Gly Arg Arg Tyr  Cys Asp Pro Val Val  Leu Thr Tyr 
    1535                 1540                 1545             


Gln Ala  Glu Arg Met Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly 
    1550                 1555                 1560             


Val Asp  Pro Lys Gln Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn 
    1565                 1570                 1575             


Val Pro  Gly Phe Leu Pro Thr  Asn Asp Leu Ser Gln  Pro Thr Gly 
    1580                 1585                 1590             


Phe Leu  Ala Gln Pro Met Lys  Gln Ala Trp Ala Thr  Asp Asp Val 
    1595                 1600                 1605             


Ala Gln  Ile Tyr Asp Lys Cys  Ile Thr Glu Leu Glu  Gln His Leu 
    1610                 1615                 1620             


His Ala  Ile Pro Pro Thr Leu  Ala Met Asn Pro Gln  Ala Gln Ala 
    1625                 1630                 1635             


Leu Arg  Ser Leu Leu Glu Val  Val Val Leu Ser Arg  Asn Ser Arg 
    1640                 1645                 1650             


Asp Ala  Ile Ala Ala Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly 
    1655                 1660                 1665             


Leu Leu  Asp Ala Thr Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg 
    1670                 1675                 1680             


Tyr Arg  Glu Cys His Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly 
    1685                 1690                 1695             


Arg Ala  Tyr Gly Ser Pro Trp  Cys Asn Lys Gln Ile  Thr Arg Cys 
    1700                 1705                 1710             


Leu Ile  Glu Cys Arg Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val 
    1715                 1720                 1725             


Glu Leu  Leu Ile Arg Asn His  Leu Val Asn Met Gln  Gln Tyr Asp 
    1730                 1735                 1740             


Leu His  Leu Ala Gln Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala 
    1745                 1750                 1755             


Val Ala  Phe Ala Met Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu 
    1760                 1765                 1770             


Arg Ser  Val Ala His Val Thr  Glu Ala Asp Leu Phe  His Thr Ile 
    1775                 1780                 1785             


Glu Thr  Leu Met Arg Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro 
    1790                 1795                 1800             


Glu Gly  Leu Pro Gln Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu 
    1805                 1810                 1815             


Ala Met  Ile Asp Arg Ala His  Gly Gly Pro Asn Phe  Met Met His 
    1820                 1825                 1830             


Ser Gly  Ile Ser Gln Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu 
    1835                 1840                 1845             


Arg Glu  Lys Ala Glu Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr 
    1850                 1855                 1860             


His Ser  Ala Ala Ala Gly Arg  Asp Ser Thr Lys Ala  Phe Ser Ala 
    1865                 1870                 1875             


Phe Val  Gly Gln Met His Gln  Gln Gly Ile Leu Lys  Thr Asp Asp 
    1880                 1885                 1890             


Leu Ile  Thr Arg Phe Phe Arg  Leu Cys Thr Glu Met  Cys Val Glu 
    1895                 1900                 1905             


Ile Ser  Tyr Arg Ala Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala 
    1910                 1915                 1920             


Asn Pro  Thr Met Ile Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala 
    1925                 1930                 1935             


Phe Val  Arg Leu Ile Ala Leu  Leu Val Lys His Ser  Gly Glu Ala 
    1940                 1945                 1950             


Thr Asn  Thr Val Thr Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly 
    1955                 1960                 1965             


Ile Val  Val Gly Val Leu Leu  Gln Asp His Asp Val  Arg Gln Ser 
    1970                 1975                 1980             


Glu Phe  Gln Gln Leu Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu 
    1985                 1990                 1995             


Leu Glu  Leu Asn Ala Pro Glu  His Val Leu Glu Thr  Ile Asn Phe 
    2000                 2005                 2010             


Gln Thr  Leu Thr Ala Phe Cys  Asn Thr Phe His Ile  Leu Arg Pro 
    2015                 2020                 2025             


Thr Lys  Ala Pro Gly Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser 
    2030                 2035                 2040             


His Arg  Ile Phe Ile Ala Arg  Met Leu Ala His Thr  Pro Gln Gln 
    2045                 2050                 2055             


Lys Gly  Trp Pro Met Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys 
    2060                 2065                 2070             


Tyr Leu  Ala Pro Phe Leu Arg  Asn Val Glu Leu Thr  Lys Pro Met 
    2075                 2080                 2085             


Gln Ile  Leu Tyr Lys Gly Thr  Leu Arg Val Leu Leu  Val Leu Leu 
    2090                 2095                 2100             


His Asp  Phe Pro Glu Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys 
    2105                 2110                 2115             


Asp Val  Ile Pro Pro Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu 
    2120                 2125                 2130             


Ser Ala  Phe Pro Arg Asn Met  Arg Leu Pro Asp Pro  Phe Thr Pro 
    2135                 2140                 2145             


Asn Leu  Lys Val Asp Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg 
    2150                 2155                 2160             


Ile Leu  Thr Asn Phe Thr Gly  Val Met Pro Pro Gln  Phe Lys Lys 
    2165                 2170                 2175             


Asp Leu  Asp Ser Tyr Leu Lys  Thr Arg Ser Pro Val  Thr Phe Leu 
    2180                 2185                 2190             


Ser Asp  Leu Arg Ser Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn 
    2195                 2200                 2205             


Arg Tyr  Asn Leu Gln Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly 
    2210                 2215                 2220             


Thr Gln  Ala Ile Ala His Ile  His Asn Lys Gly Ser  Thr Pro Ser 
    2225                 2230                 2235             


Met Ser  Thr Ile Thr His Ser  Ala His Met Asp Ile  Phe Gln Asn 
    2240                 2245                 2250             


Leu Ala  Val Asp Leu Asp Thr  Glu Gly Arg Tyr Leu  Phe Leu Asn 
    2255                 2260                 2265             


Ala Ile  Ala Asn Gln Leu Arg  Tyr Pro Asn Ser His  Thr His Tyr 
    2270                 2275                 2280             


Phe Ser  Cys Thr Met Leu Tyr  Leu Phe Ala Glu Ala  Asn Thr Glu 
    2285                 2290                 2295             


Ala Ile  Gln Glu Gln Ile Thr  Arg Val Leu Leu Glu  Arg Leu Ile 
    2300                 2305                 2310             


Val Asn  Arg Pro His Pro Trp  Gly Leu Leu Ile Thr  Phe Ile Glu 
    2315                 2320                 2325             


Leu Ile  Lys Asn Pro Ala Phe  Lys Phe Trp Asn His  Glu Phe Val 
    2330                 2335                 2340             


His Cys  Ala Pro Glu Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln 
    2345                 2350                 2355             


Cys Cys  Met Gly Gln Lys Gln  Ala Gln Gln Val Met  Glu Gly Thr 
    2360                 2365                 2370             


Gly Ala  Ser 
    2375     


<210>  475
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  475
atgtggcagc tcacaagcct cctgctgttc gtggccacct ggggaatttc cggcacacca       60

gctcctcttg actcagtgtt ctccagcagc gagcgtgccc accaggtgct gcggatccgc      120

aaacgtgcca actccttcct ggaggagctc cgtcacagca gcctggagcg ggagtgcata      180

gaggagatct gtgacttcga ggaggccaag gaaattttcc aaaatgtgga tgacacactg      240

gccttctggt ccaagcacgt cgacggtgac cagtgcttgg tcttgccctt ggagcacccg      300

tgcgccagcc tgtgctgcgg gcacggcacg tgcatcgacg gcatcggcag cttcagctgc      360

gactgccgca gcggctggga gggccgcttc tgccagcgcg aggtgagctt cctcaattgc      420

tcgctggaca acggcggctg cacgcattac tgcctagagg aggtgggctg gcggcgctgt      480

agctgtgcgc ctggctacaa gctgggggac gacctcctgc agtgtcaccc cgcagtgaag      540

ttcccttgtg ggaggccctg gaagcggatg gagaagaagc gcagtcacct gaaacgagac      600

acagaagacc aagaagacca agtagatccg cggctcattg atgggaagat gaccaggcgg      660

ggagacagcc cctggcaggt ggtcctgctg gactcaaaga agaagctggc ctgcggggca      720

gtgctcatcc acccctcctg ggtgctgaca gcggcccact gcatggatga gtccaagaag      780

ctccttgtca ggcttggaga gtatgacctg cggcgctggg agaagtggga gctggacctg      840

gacatcaagg aggtcttcgt ccaccccaac tacagcaaga gcaccaccga caatgacatc      900

gcactgctgc acctggccca gcccgccacc ctctcgcaga ccatagtgcc catctgcctc      960

ccggacagcg gccttgcaga gcgcgagctc aatcaggccg gccaggagac cctcgtgacg     1020

ggctggggct accacagcag ccgagagaag gaggccaaga gaaaccgcac cttcgtcctc     1080

aacttcatca agattcccgt ggtcccgcac aatgagtgca gcgaggtcat gagcaacatg     1140

gtgtctgaga acatgctgtg tgcgggcatc ctcggggacc ggcaggatgc ctgcgagggc     1200

gacagtgggg ggcccatggt cgcctccttc cacggcacct ggttcctggt gggcctggtg     1260

agctggggtg agggctgtgg gctccttcac aactacggcg tttacaccaa agtcagccgc     1320

tacctcgact ggatccatgg gcacatcaga gacaaggaag ccccccagaa gagctgggca     1380

ccttag                                                                1386


<210>  476
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  477
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  477
atggccaaca tcgcggtgca gcgaatcaag cgggagttca aggaggtgct gaagagcgag       60

gagacgagca aaaatcaaat taaagtagat cttgtagatg agaattttac agaattaaga      120

ggagaaatag caggacctcc agacacacca tatgaaggag gaagatacca actagagata      180

aaaataccag aaacataccc atttaatccc cctaaggtcc ggtttatcac taaaatatgg      240

catcctaata ttagttccgt cacaggggct atttgtttgg atatcctgaa agatcaatgg      300

gcagctgcaa tgactctccg cacggtatta ttgtcattgc aagcactatt ggcagctgca      360

gagccagatg atccacagga tgctgtagta gcaaatcagt acaaacaaaa tcccgaaatg      420

ttcaaacaga cagctcgact ttgggcacat gtgtatgctg gagcaccagt ttctagtcca      480

gaatacacca aaaaaataga aaacctatgt gctatgggct ttgataggaa tgcagtaata      540

gtggccttgt cttcaaaatc atgggatgta gagactgcaa cagaattgct tctgagtaac      600

tga                                                                    603


<210>  478
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  


His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      


Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         


Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             


Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr 
    130                 135                 140                 


Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro 
145                 150                 155                 160 


Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg 
                165                 170                 175     


Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr 
            180                 185                 190         


Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200 


<210>  479
<211>  5466
<212>  DNA
<213>  Homo sapiens

<400>  479
atgaggccgc ggaccaaagc ccgcagcccg gggcgcgccc tgcggaaccc ctggagaggc       60

ttcctgccgc tcaccctggc tctcttcgtg ggcgcgggtc atgcccaaag ggaccccgta      120

gggagatacg agccggctgg tggagacgcg aatcgactgc ggcgccctgg gggcagctac      180

ccggcagcgg ctgcagccaa ggtgtacagt ctgttccggg agcaggacgc gcctgtcgcg      240

ggcttgcagc ccgtggagcg ggcccagccg ggctggggga gccccaggag gcccaccgag      300

gcggaggcca ggaggccgtc ccgcgcgcag cagtcgcggc gtgtccagcc acctgcgcag      360

acccggagaa gcactcccct gggccagcag caaccagcac cccggacccg ggccgcgccg      420

gctctcccac gcctggggac cccacagcgg tctggggctg cgcccccaac cccgccgcga      480

gggcggctca cggggaggaa cgtctgcggg ggacagtgct gcccaggatg gacaacagca      540

aacagcacca accactgtat caaacccgtt tgcgagccgc cgtgccagaa ccggggctcc      600

tgcagccgcc cgcagctctg tgtctgccgc tctggtttcc gtggagcccg ctgcgaggag      660

gtcattcccg atgaggaatt tgacccccag aactccaggc tggcacctcg acgctgggcc      720

gagcgttcac ccaacctgcg caggagcagt gcggctggag agggcacctt ggccagagca      780

cagccgccag caccacagtc gccgcccgca ccacagtcgc caccagctgg gaccctgagt      840

ggcctcagcc agacccaccc ttcccagcag cacgtggggt tgtcccgcac tgtccgactt      900

cacccgactg ccacggccag tagccagctc tcttccaacg ccctgccccc gggaccaggc      960

cttgagcaga gagatggcac ccaacaggcg gtacctctgg agcacccctc atccccctgg     1020

gggctgaacc tcacggagaa aatcaagaag atcaagatcg tcttcactcc caccatctgc     1080

aagcagacct gtgcccgtgg acactgtgcc aacagctgtg agaggggcga caccaccacc     1140

ctgtacagcc agggcggcca tgggcacgat cccaagtctg gcttccgcat ctatttctgc     1200

cagatcccct gcctgaacgg aggccgctgc atcggcaggg acgaatgctg gtgccccgcc     1260

aactccaccg ggaagttctg ccacctgcct atcccgcagc cggacaggga gcctccaggg     1320

agggggtccc gccccagggc cttgctggaa gccccactga agcagtccac tttcacactg     1380

ccgctctcca accagctggc ctccgtgaac ccctccctgg tgaaggtgca cattcaccac     1440

ccacccgagg cctcagtgca gatccaccag gtggcccagg tgcggggcgg ggtggaggag     1500

gccctagtgg agaacagcgt ggagaccaga cccccgccct ggctgcctgc cagccctggc     1560

cacagcctct gggacagcaa caacatccct gctcggtctg gagagccccc tcggccactg     1620

cccccagcag cacccaggcc tcgaggactg ctgggccggt gttacctgaa cactgtgaac     1680

ggacagtgtg ccaaccctct gctggagctg actacccagg aggactgctg tggcagtgtg     1740

ggagccttct ggggggtgac tttgtgtgcc ccatgcccac ccagaccagc ctccccggtg     1800

attgagaatg gccagctgga gtgtcctcag gggtacaaga gactgaacct cactcactgc     1860

caagatatca acgagtgctt gaccctgggc ctgtgcaagg acgcggagtg tgtgaatacc     1920

aggggcagct acctgtgcac atgcagacct ggcctcatgc tggatccatc gcggagccgc     1980

tgtgtgtcgg acaaggcaat ctccatgctg cagggactgt gctaccggtc gctggggccc     2040

ggcacctgca ccctgccttt ggcccagcgg atcaccaagc agatatgctg ctgcagccgc     2100

gtgggcaaag catggggcag cgagtgtgag aaatgccctc tgcctggcac agaggccttc     2160

agagagatct gccctgccgg ccacggctac acctacgcga gctccgacat ccgcctgtcc     2220

atgaggaaag ccgaggagga ggaactggca aggcccccaa gggagcaagg gcagaggagc     2280

agcggggcac tgcccgggcc agcagagagg cagcccctcc gggtcgtcac ggacacctgg     2340

cttgaggccg ggaccatccc tgacaagggt gactctcagg ctggccaggt cacgaccagt     2400

gtcactcatg cacctgcctg ggtcacaggg aatgccacaa ccccaccaat gcctgaacag     2460

gggattgcag agatacagga agaacaagtg accccctcca ctgatgtgct ggtgaccctg     2520

agcaccccag gcattgacag atgcgctgct ggagccacca acgtctgtgg ccctggaacc     2580

tgcgtgaacc tccccgatgg atacagatgt gtctgcagcc ctggctacca gctgcacccc     2640

agccaggcct actgcacaga tgacaacgag tgtctgaggg acccctgcaa gggaaaaggg     2700

cgctgcatca accgcgtggg gtcctactcc tgcttctgct accctggcta cactctggcc     2760

acctcagggg cgacacagga gtgtcaagat atcaatgagt gtgagcagcc aggggtgtgc     2820

agcggggggc agtgcaccaa caccgagggc tcgtaccact gcgagtgtga tcagggctac     2880

atcatggtca ggaaaggaca ctgccaagat atcaacgaat gccgtcaccc cggtacctgc     2940

cctgatggga gatgcgtcaa ttcccctggc tcctacactt gtctggcctg tgaggagggc     3000

taccggggcc agagtgggag ctgtgtagat gtgaatgagt gtctgactcc cggggtctgt     3060

gcccatggaa agtgcaccaa cctagaaggc tccttcagat gctcttgtga gcagggctat     3120

gaggtcacct cagatgagaa gggctgccaa gatgtggatg agtgtgccag ccgggcctca     3180

tgccccacag gcctctgcct caacacggag ggctccttcg cctgctctgc ctgtgagaac     3240

gggtactggg tgaatgaaga cggcactgcc tgtgaagacc tagatgagtg tgccttcccg     3300

ggagtctgcc cctccggagt ctgcaccaac acggctggct ccttctcctg caaggactgc     3360

gatgggggct accggcccag ccccctgggt gactcctgtg aagatgtgga tgaatgtgaa     3420

gacccccaga gcagctgcct gggaggcgag tgcaagaaca ctgtgggctc ctaccagtgc     3480

ctctgtcccc agggcttcca gctggccaat ggcaccgtgt gtgaggatgt gaatgagtgc     3540

atgggggagg agcactgcgc accccacggc gagtgcctca acagccacgg gtctttcttc     3600

tgtctgtgcg cgcctggctt cgtcagcgca gaggggggca ccagctgcca ggatgtggac     3660

gagtgtgcca ccacagaccc gtgtgtggga gggcactgtg tcaacaccga gggctccttc     3720

aactgtctat gtgagactgg cttccagccc tccccagaga gtggagagtg tgtggatatt     3780

gacgagtgtg aggactatgg agacccggtg tgtggcacct ggaagtgtga aaacagccct     3840

ggctcctacc gctgtgttct gggctgccag cctggcttcc acatggcccc gaacggagac     3900

tgcattgaca tagacgagtg cgccaacgac accatgtgtg gcagccacgg cttctgtgac     3960

aacactgatg gctccttccg ctgcctctgt gaccagggct tcgagatctc tccctcaggc     4020

tgggactgtg tggatgtgaa cgagtgtgag cttatgctgg cggtatgtgg ggccgcgctc     4080

tgtgagaacg tggagggctc cttcctgtgc ctctgtgcca gtgacctgga ggagtacgat     4140

gcccaggagg ggcactgccg cccacggggg gctggaggtc agagtatgtc tgaggcccca     4200

acgggggacc atgccccggc ccccacccgc atggactgct actccgggca gaagggccat     4260

gcgccctgct ccagtgtcct gggccggaac accacacagg ctgaatgctg ctgcacccag     4320

ggcgctagct ggggagatgc ctgtgacctc tgcccgtctg aggactcagc tgaattcagc     4380

gagatctgcc ctagtggaaa aggctacatt cctgtggaag gagcctggac gtttggacag     4440

accatgtaca cagatgcgga tgagtgtgtg atattcgggc ctggtctctg cccgaacggc     4500

cggtgcctca acaccgtgcc tggttatgtc tgcctgtgca atcccggctt ccactacgat     4560

gcttcccaca agaagtgtga ggatcacgat gagtgccagg acctggcctg tgagaatggc     4620

gagtgcgtca acacggaggg ctccttccac tgcttctgca gccccccgct caccctggac     4680

ctcagccagc agcgctgcat gaacagcacc agcagcacgg aggacctccc tgaccacgac     4740

atccacatgg acatctgctg gaaaaaagtc accaatgatg tgtgcagcga acccctgcgt     4800

gggcaccgca ccacctacac ggaatgctgc tgccaggacg gcgaggcctg gagccagcag     4860

tgtgctctgt gtcccccgag gagctctgag gtctatgctc agctgtgcaa cgtggctcgc     4920

attgaggcag agcgggaggc cggggtccac ttccggccag gctatgagta tggccccggg     4980

cccgatgacc tgcactacag catctatggc ccagatgggg cccccttcta caactacctg     5040

ggccccgagg acaccgtccc tgagcctgcc ttccccaaca cagccggtca ctcagcggac     5100

cgcacaccca tccttgagtc tcctttgcag ccctcagaac tccagcccca ctacgtggcc     5160

agccatccag agcccccagc cggcttcgaa gggcttcagg cggaggagtg cggcatcctg     5220

aacggctgtg agaatggccg ctgtgtgcgc gtgcgggagg gctacacctg tgactgtttt     5280

gagggcttcc agctggatgc ggcccacatg gcctgcgtag atgtgaatga gtgtgatgac     5340

ttgaacgggc ctgctgtgct ctgtgtccat ggttactgcg agaacacaga gggctcctac     5400

cgctgccact gctccccggg atatgtggct gaggcagggc ccccccactg cactgccaag     5460

gagtag                                                                5466


<210>  480
<211>  1821
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Glu Asp  Tyr Gly Asp Pro Val  Cys Gly Thr Trp Lys  Cys Glu Asn 
    1265                 1270                 1275             


Ser Pro  Gly Ser Tyr Arg Cys  Val Leu Gly Cys Gln  Pro Gly Phe 
    1280                 1285                 1290             


His Met  Ala Pro Asn Gly Asp  Cys Ile Asp Ile Asp  Glu Cys Ala 
    1295                 1300                 1305             


Asn Asp  Thr Met Cys Gly Ser  His Gly Phe Cys Asp  Asn Thr Asp 
    1310                 1315                 1320             


Gly Ser  Phe Arg Cys Leu Cys  Asp Gln Gly Phe Glu  Ile Ser Pro 
    1325                 1330                 1335             


Ser Gly  Trp Asp Cys Val Asp  Val Asn Glu Cys Glu  Leu Met Leu 
    1340                 1345                 1350             


Ala Val  Cys Gly Ala Ala Leu  Cys Glu Asn Val Glu  Gly Ser Phe 
    1355                 1360                 1365             


Leu Cys  Leu Cys Ala Ser Asp  Leu Glu Glu Tyr Asp  Ala Gln Glu 
    1370                 1375                 1380             


Gly His  Cys Arg Pro Arg Gly  Ala Gly Gly Gln Ser  Met Ser Glu 
    1385                 1390                 1395             


Ala Pro  Thr Gly Asp His Ala  Pro Ala Pro Thr Arg  Met Asp Cys 
    1400                 1405                 1410             


Tyr Ser  Gly Gln Lys Gly His  Ala Pro Cys Ser Ser  Val Leu Gly 
    1415                 1420                 1425             


Arg Asn  Thr Thr Gln Ala Glu  Cys Cys Cys Thr Gln  Gly Ala Ser 
    1430                 1435                 1440             


Trp Gly  Asp Ala Cys Asp Leu  Cys Pro Ser Glu Asp  Ser Ala Glu 
    1445                 1450                 1455             


Phe Ser  Glu Ile Cys Pro Ser  Gly Lys Gly Tyr Ile  Pro Val Glu 
    1460                 1465                 1470             


Gly Ala  Trp Thr Phe Gly Gln  Thr Met Tyr Thr Asp  Ala Asp Glu 
    1475                 1480                 1485             


Cys Val  Ile Phe Gly Pro Gly  Leu Cys Pro Asn Gly  Arg Cys Leu 
    1490                 1495                 1500             


Asn Thr  Val Pro Gly Tyr Val  Cys Leu Cys Asn Pro  Gly Phe His 
    1505                 1510                 1515             


Tyr Asp  Ala Ser His Lys Lys  Cys Glu Asp His Asp  Glu Cys Gln 
    1520                 1525                 1530             


Asp Leu  Ala Cys Glu Asn Gly  Glu Cys Val Asn Thr  Glu Gly Ser 
    1535                 1540                 1545             


Phe His  Cys Phe Cys Ser Pro  Pro Leu Thr Leu Asp  Leu Ser Gln 
    1550                 1555                 1560             


Gln Arg  Cys Met Asn Ser Thr  Ser Ser Thr Glu Asp  Leu Pro Asp 
    1565                 1570                 1575             


His Asp  Ile His Met Asp Ile  Cys Trp Lys Lys Val  Thr Asn Asp 
    1580                 1585                 1590             


Val Cys  Ser Glu Pro Leu Arg  Gly His Arg Thr Thr  Tyr Thr Glu 
    1595                 1600                 1605             


Cys Cys  Cys Gln Asp Gly Glu  Ala Trp Ser Gln Gln  Cys Ala Leu 
    1610                 1615                 1620             


Cys Pro  Pro Arg Ser Ser Glu  Val Tyr Ala Gln Leu  Cys Asn Val 
    1625                 1630                 1635             


Ala Arg  Ile Glu Ala Glu Arg  Glu Ala Gly Val His  Phe Arg Pro 
    1640                 1645                 1650             


Gly Tyr  Glu Tyr Gly Pro Gly  Pro Asp Asp Leu His  Tyr Ser Ile 
    1655                 1660                 1665             


Tyr Gly  Pro Asp Gly Ala Pro  Phe Tyr Asn Tyr Leu  Gly Pro Glu 
    1670                 1675                 1680             


Asp Thr  Val Pro Glu Pro Ala  Phe Pro Asn Thr Ala  Gly His Ser 
    1685                 1690                 1695             


Ala Asp  Arg Thr Pro Ile Leu  Glu Ser Pro Leu Gln  Pro Ser Glu 
    1700                 1705                 1710             


Leu Gln  Pro His Tyr Val Ala  Ser His Pro Glu Pro  Pro Ala Gly 
    1715                 1720                 1725             


Phe Glu  Gly Leu Gln Ala Glu  Glu Cys Gly Ile Leu  Asn Gly Cys 
    1730                 1735                 1740             


Glu Asn  Gly Arg Cys Val Arg  Val Arg Glu Gly Tyr  Thr Cys Asp 
    1745                 1750                 1755             


Cys Phe  Glu Gly Phe Gln Leu  Asp Ala Ala His Met  Ala Cys Val 
    1760                 1765                 1770             


Asp Val  Asn Glu Cys Asp Asp  Leu Asn Gly Pro Ala  Val Leu Cys 
    1775                 1780                 1785             


Val His  Gly Tyr Cys Glu Asn  Thr Glu Gly Ser Tyr  Arg Cys His 
    1790                 1795                 1800             


Cys Ser  Pro Gly Tyr Val Ala  Glu Ala Gly Pro Pro  His Cys Thr 
    1805                 1810                 1815             


Ala Lys  Glu 
    1820     


<210>  481
<211>  4395
<212>  DNA
<213>  Homo sapiens

<400>  481
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt       60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg      120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg      180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag      240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt      300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc      360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg      420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag      480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac      540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg      600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag      660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg      720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg      780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc      840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc      900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc      960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat     1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg     1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac     1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag     1200

ccggatgaca accatctcag catcgtcacc ctggaggagg ccccattcgt catcgtggaa     1260

gacatagacc ccctgaccga gacgtgtgtg aggaacaccg tgccatgtcg gaagttcgtc     1320

aaaatcaaca attcaaccaa tgaggggatg aatgtgaaga aatgctgcaa ggggttctgc     1380

attgatattc tgaagaagct ttccagaact gtgaagttta cttacgacct ctatctggtg     1440

accaatggga agcatggcaa gaaagttaac aatgtgtgga atggaatgat cggtgaagtg     1500

gtctatcaac gggcagtcat ggcagttggc tcgctcacca tcaatgagga acgttctgaa     1560

gtggtggact tctctgtgcc ctttgtggaa acgggaatca gtgtcatggt ttcaagaagt     1620

aatggcaccg tctcaccttc tgcttttcta gaaccattca gcgcctctgt ctgggtgatg     1680

atgtttgtga tgctgctcat tgtttctgcc atagctgttt ttgtctttga atacttcagc     1740

cctgttggat acaacagaaa cttagccaaa gggaaagcac cccatgggcc ttcttttaca     1800

attggaaaag ctatatggct tctttggggc ctggtgttca ataactccgt gcctgtccag     1860

aatcctaaag ggaccaccag caagatcatg gtatctgtat gggccttctt cgctgtcata     1920

ttcctggcta gctacacagc caatctggct gccttcatga tccaagagga atttgtggac     1980

caagtgaccg gcctcagtga caaaaagttt cagagacctc atgactattc cccacctttt     2040

cgatttggga cagtgcctaa tggaagcacg gagagaaaca ttcggaataa ctatccctac     2100

atgcatcagt acatgaccaa atttaatcag aaaggagtag aggacgcctt ggtcagcctg     2160

aaaacgggga agctggacgc tttcatctac gatgccgcag tcttgaatta caaggctggg     2220

agggatgaag gctgcaagct ggtgaccatc gggagtgggt acatctttgc caccaccggt     2280

tatggaattg cccttcagaa aggctctcct tggaagaggc agatcgacct ggccttgctt     2340

cagtttgtgg gtgatggtga gatggaggag ctggagaccc tgtggctcac tgggatctgc     2400

cacaacgaga agaacgaggt gatgagcagc cagctggaca ttgacaacat ggcgggcgta     2460

ttctacatgc tggctgccgc catggccctt agcctcatca ccttcatctg ggagcacctc     2520

ttctactgga agctgcgctt ctgtttcacg ggcgtgtgct ccgaccggcc tgggttgctc     2580

ttctccatca gcaggggcat ctacagctgc attcatggag tgcacattga agaaaagaag     2640

aagtctccag acttcaatct gacgggatcc cagagcaaca tgttaaaact cctccggtca     2700

gccaaaaaca tttccagcat gtccaacatg aactcctcaa gaatggactc acccaaaaga     2760

gctgctgact tcatccaaag aggttccctc atcatggaca tggtttcaga taaggggaat     2820

ttgatgtact cagacaacag gtcctttcag gggaaagaga gcatttttgg agacaacatg     2880

aacgaactcc aaacatttgt ggccaaccgg cagaaggata acctcaataa ctatgtattc     2940

cagggacaac atcctcttac tctcaatgag tccaacccta acacggtgga ggtggccgtg     3000

agcacagaat ccaaagcgaa ctctagaccc cggcagctgt ggaagaaatc cgtggattcc     3060

atacgccagg attcactatc ccagaatcca gtctcccaga gggatgaggc aacagcagag     3120

aataggaccc actccctaaa gagccctagg tatcttccag aagagatggc ccactctgac     3180

atttcagaaa cgtcaaatcg ggccacgtgc cacagggaac ctgacaacag taagaaccac     3240

aaaaccaagg acaactttaa aaggtcagtg gcctccaaat accccaagga ctgtagtgag     3300

gtcgagcgca cctacctgaa aaccaaatca agctccccta gagacaagat ctacactata     3360

gatggtgaga aggagcctgg tttccactta gatccacccc agtttgttga aaatgtgacc     3420

ctgcccgaga acgtggactt cccggacccc taccaggatc ccagtgaaaa cttccgcaag     3480

ggggactcca cgctgccaat gaaccggaac cccttgcata atgaagaggg gctttccaac     3540

aacgaccagt ataaactcta ctccaagcac ttcaccttga aagacaaggg ttccccgcac     3600

agtgagacca gcgagcgata ccggcagaac tccacgcact gcagaagctg cctttccaac     3660

atgcccacct attcaggcca cttcaccatg aggtccccct tcaagtgcga tgcctgcctg     3720

cggatgggga acctctatga catcgatgaa gaccagatgc ttcaggagac aggtaaccca     3780

gccaccgggg agcaggtcta ccagcaggac tgggcacaga acaatgccct tcaattacaa     3840

aagaacaagc taaggattag ccgtcagcat tcctacgata acattgtcga caaacctagg     3900

gagctagacc ttagcaggcc ctcccggagc ataagcctca aggacaggga acggcttctg     3960

gagggaaatt tttacggcag cctgtttagt gtcccctcaa gcaaactctc ggggaaaaaa     4020

agctcccttt tcccccaagg tctggaggac agcaagagga gcaagtctct cttgccagac     4080

cacacctccg ataacccttt cctccactcc cacagggatg accaacgctt ggttattggg     4140

agatgcccct cggaccctta caaacactcg ttgccatccc aggcggtgaa tgacagctat     4200

cttcggtcgt ccttgaggtc aacggcatcg tactgttcca gggacagtcg gggccacaat     4260

gatgtgtata tttcggagca tgttatgcct tatgctgcaa ataagaataa tatgtactct     4320

acccccaggg ttttaaattc ctgcagcaat agacgcgtgt acaagaaaat gcctagtatc     4380

gaatctgatg tttaa                                                      4395


<210>  482
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  483
<211>  2289
<212>  DNA
<213>  Homo sapiens

<400>  483
atgggaaatg gttcagtgaa acctaaacat tctaagcacc cagatggaca ctctgggaac       60

ctcaccactg atgctctgcg gaacaaggtg acagagctgg agagagagtt gaggaggaag      120

gatgctgaga tccaggagcg ggagtaccat ttgaaggagc tgcgggagca gctgtcgaag      180

cagactgtgg ccattgctga actcacagag gagctccaga acaagtgcat ccagctgaac      240

aagctgcagg atgtggtgca tatgcaggga ggaagcccgc ttcaggcctc tccagataaa      300

gtgcctcttg aggtccaccg gaagacctct ggattggtct ctctccatag caggagggga      360

gcaaaggctg gcgtgtctgc tgagccaaca acccggacct atgacctgaa caaaccccct      420

gaattttcct ttgagaaagc aagagtcaga aaagactcca gtgagaagaa gctcattaca      480

gatgccctta ataaaaatca gtttctgaaa agactggatc ctcagcagat caaagacatg      540

gtggaatgca tgtatgggag aaactatcag caagggagtt acattattaa gcaaggagaa      600

ccaggaaacc atatctttgt gctggcagag ggtcgactag aggtgttcca aggggagaaa      660

ttgctgtcct ccatccctat gtggaccaca tttggggagc ttgccatttt atacaattgt      720

acaaggactg cctctgtgaa agctattacc aatgttaaaa catgggcact agatcgagag      780

gtattccaga atataatgag gaggacagcc caagctagag atgaacaata cagaaacttc      840

ctcagaagtg tatccttgct gaagaattta cctgaagata aattaaccaa gatcattgac      900

tgcttggaag tggaatacta tgacaaagga gattacatca ttagagaggg cgaggaagga      960

agtacctttt tcattttggc aaaaggaaag gtaaaagtaa cacagagcac agaaggccat     1020

gatcaaccac agctgataaa aacactgcag aaaggagaat actttggaga aaaagctctt     1080

atcagtgatg atgtcaggtc agctaacatt attgctgaag aaaatgatgt tgcatgcctg     1140

gttatagatc gagaaacatt caaccaaact gtcggtacat ttgaagagct gcaaaaatac     1200

cttgaaggat atgtggcaaa cctgaaccgt gatgatgaaa aaagacatgc gaagcggtcc     1260

atgtctaact ggaagctgtc caaagcactc tctctggaaa tgattcagct gaaggagaag     1320

gtggccagat tttcctcatc atccccattc cagaaccttg agattattgc aacactgggc     1380

gttggtgggt tcggaagagt tgagcttgtt aaagtaaaaa atgagaatgt tgcttttgct     1440

atgaagtgta taaggaagaa gcacatagtt gacaccaagc agcaggagca tgtctactca     1500

gagaagagga tcctagagga gctgtgctct ccattcattg tgaaattata tcgtactttc     1560

aaggacaata agtatgtata catgcttctg gaggcctgct taggtgggga gctctggagt     1620

atattaaggg acagaggcag ctttgatgaa cccacctcca aattctgcgt tgcttgtgtg     1680

acagaagcat ttgattacct gcatcgacta ggtattatct acagagactt gaaaccagaa     1740

aacttaattc tagatgctga gggttacctt aaattggttg actttggatt tgcgaagaaa     1800

atagggtctg gacagaaaac atggacattc tgtgggactc cagaatatgt agctcctgaa     1860

gtcattctca acaagggaca tgacttcagt gtggatttct ggtcactggg aattctagtg     1920

tatgagctcc taacgggcaa cccacccttt tctggggttg accaaatgat gacctacaat     1980

ttgattctca aaggaattga aaaaatggat tttcccagga agataacacg acgacctgag     2040

gatttgattc ggaggctttg caggcaaaat ccaacagaaa ggctgggaaa tctgaagaat     2100

ggaataaatg acattaagaa acacaggtgg ttaaatggtt ttaattggga gggactgaaa     2160

gcacggagcc ttccatcacc tttgcaaaga gagctcaagg gacccataga tcacagctac     2220

tttgacaaat atcctcctga aaagggaatg cctccagatg agctatcagg ctgggataaa     2280

gacttctga                                                             2289


<210>  484
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Gly Asn Gly Ser Val Lys Pro Lys His Ser Lys His Pro Asp Gly 
1               5                   10                  15      


His Ser Gly Asn Leu Thr Thr Asp Ala Leu Arg Asn Lys Val Thr Glu 
            20                  25                  30          


Leu Glu Arg Glu Leu Arg Arg Lys Asp Ala Glu Ile Gln Glu Arg Glu 
        35                  40                  45              


Tyr His Leu Lys Glu Leu Arg Glu Gln Leu Ser Lys Gln Thr Val Ala 
    50                  55                  60                  


Ile Ala Glu Leu Thr Glu Glu Leu Gln Asn Lys Cys Ile Gln Leu Asn 
65                  70                  75                  80  


Lys Leu Gln Asp Val Val His Met Gln Gly Gly Ser Pro Leu Gln Ala 
                85                  90                  95      


Ser Pro Asp Lys Val Pro Leu Glu Val His Arg Lys Thr Ser Gly Leu 
            100                 105                 110         


Val Ser Leu His Ser Arg Arg Gly Ala Lys Ala Gly Val Ser Ala Glu 
        115                 120                 125             


Pro Thr Thr Arg Thr Tyr Asp Leu Asn Lys Pro Pro Glu Phe Ser Phe 
    130                 135                 140                 


Glu Lys Ala Arg Val Arg Lys Asp Ser Ser Glu Lys Lys Leu Ile Thr 
145                 150                 155                 160 


Asp Ala Leu Asn Lys Asn Gln Phe Leu Lys Arg Leu Asp Pro Gln Gln 
                165                 170                 175     


Ile Lys Asp Met Val Glu Cys Met Tyr Gly Arg Asn Tyr Gln Gln Gly 
            180                 185                 190         


Ser Tyr Ile Ile Lys Gln Gly Glu Pro Gly Asn His Ile Phe Val Leu 
        195                 200                 205             


Ala Glu Gly Arg Leu Glu Val Phe Gln Gly Glu Lys Leu Leu Ser Ser 
    210                 215                 220                 


Ile Pro Met Trp Thr Thr Phe Gly Glu Leu Ala Ile Leu Tyr Asn Cys 
225                 230                 235                 240 


Thr Arg Thr Ala Ser Val Lys Ala Ile Thr Asn Val Lys Thr Trp Ala 
                245                 250                 255     


Leu Asp Arg Glu Val Phe Gln Asn Ile Met Arg Arg Thr Ala Gln Ala 
            260                 265                 270         


Arg Asp Glu Gln Tyr Arg Asn Phe Leu Arg Ser Val Ser Leu Leu Lys 
        275                 280                 285             


Asn Leu Pro Glu Asp Lys Leu Thr Lys Ile Ile Asp Cys Leu Glu Val 
    290                 295                 300                 


Glu Tyr Tyr Asp Lys Gly Asp Tyr Ile Ile Arg Glu Gly Glu Glu Gly 
305                 310                 315                 320 


Ser Thr Phe Phe Ile Leu Ala Lys Gly Lys Val Lys Val Thr Gln Ser 
                325                 330                 335     


Thr Glu Gly His Asp Gln Pro Gln Leu Ile Lys Thr Leu Gln Lys Gly 
            340                 345                 350         


Glu Tyr Phe Gly Glu Lys Ala Leu Ile Ser Asp Asp Val Arg Ser Ala 
        355                 360                 365             


Asn Ile Ile Ala Glu Glu Asn Asp Val Ala Cys Leu Val Ile Asp Arg 
    370                 375                 380                 


Glu Thr Phe Asn Gln Thr Val Gly Thr Phe Glu Glu Leu Gln Lys Tyr 
385                 390                 395                 400 


Leu Glu Gly Tyr Val Ala Asn Leu Asn Arg Asp Asp Glu Lys Arg His 
                405                 410                 415     


Ala Lys Arg Ser Met Ser Asn Trp Lys Leu Ser Lys Ala Leu Ser Leu 
            420                 425                 430         


Glu Met Ile Gln Leu Lys Glu Lys Val Ala Arg Phe Ser Ser Ser Ser 
        435                 440                 445             


Pro Phe Gln Asn Leu Glu Ile Ile Ala Thr Leu Gly Val Gly Gly Phe 
    450                 455                 460                 


Gly Arg Val Glu Leu Val Lys Val Lys Asn Glu Asn Val Ala Phe Ala 
465                 470                 475                 480 


Met Lys Cys Ile Arg Lys Lys His Ile Val Asp Thr Lys Gln Gln Glu 
                485                 490                 495     


His Val Tyr Ser Glu Lys Arg Ile Leu Glu Glu Leu Cys Ser Pro Phe 
            500                 505                 510         


Ile Val Lys Leu Tyr Arg Thr Phe Lys Asp Asn Lys Tyr Val Tyr Met 
        515                 520                 525             


Leu Leu Glu Ala Cys Leu Gly Gly Glu Leu Trp Ser Ile Leu Arg Asp 
    530                 535                 540                 


Arg Gly Ser Phe Asp Glu Pro Thr Ser Lys Phe Cys Val Ala Cys Val 
545                 550                 555                 560 


Thr Glu Ala Phe Asp Tyr Leu His Arg Leu Gly Ile Ile Tyr Arg Asp 
                565                 570                 575     


Leu Lys Pro Glu Asn Leu Ile Leu Asp Ala Glu Gly Tyr Leu Lys Leu 
            580                 585                 590         


Val Asp Phe Gly Phe Ala Lys Lys Ile Gly Ser Gly Gln Lys Thr Trp 
        595                 600                 605             


Thr Phe Cys Gly Thr Pro Glu Tyr Val Ala Pro Glu Val Ile Leu Asn 
    610                 615                 620                 


Lys Gly His Asp Phe Ser Val Asp Phe Trp Ser Leu Gly Ile Leu Val 
625                 630                 635                 640 


Tyr Glu Leu Leu Thr Gly Asn Pro Pro Phe Ser Gly Val Asp Gln Met 
                645                 650                 655     


Met Thr Tyr Asn Leu Ile Leu Lys Gly Ile Glu Lys Met Asp Phe Pro 
            660                 665                 670         


Arg Lys Ile Thr Arg Arg Pro Glu Asp Leu Ile Arg Arg Leu Cys Arg 
        675                 680                 685             


Gln Asn Pro Thr Glu Arg Leu Gly Asn Leu Lys Asn Gly Ile Asn Asp 
    690                 695                 700                 


Ile Lys Lys His Arg Trp Leu Asn Gly Phe Asn Trp Glu Gly Leu Lys 
705                 710                 715                 720 


Ala Arg Ser Leu Pro Ser Pro Leu Gln Arg Glu Leu Lys Gly Pro Ile 
                725                 730                 735     


Asp His Ser Tyr Phe Asp Lys Tyr Pro Pro Glu Lys Gly Met Pro Pro 
            740                 745                 750         


Asp Glu Leu Ser Gly Trp Asp Lys Asp Phe 
        755                 760         


<210>  485
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  485
atggtcaacg accggtggaa gaccatgggc ggcgctgccc aacttgagga ccggccgcgc       60

gacaagccgc agcggccgag ctgcggctac gtgctgtgca ccgtgctgct ggccctggct      120

gtgctgctgg ctgtagctgt caccggtgcc gtgctcttcc tgaaccacgc ccacgcgccg      180

ggcacggcgc ccccacctgt cgtcagcact ggggctgcca gcgccaacag cgccctggtc      240

actgtggaaa gggcggacag ctcgcacctc agcatcctca ttgacccgcg ctgccccgac      300

ctcaccgaca gcttcgcacg cctggagagc gcccaggcct cggtgctgca ggcgctgaca      360

gagcaccagg cccagccacg gctggtgggc gaccaggagc aggagctgct ggacacgctg      420

gccgaccagc tgccccggct gctggcccga gcctcagagc tgcagacgga gtgcatgggg      480

ctgcggaagg ggcatggcac gctgggccag ggcctcagcg ccctgcagag tgagcagggc      540

cgcctcatcc agcttctctc tgagagccag ggccacatgg ctcacctggt gaactccgtc      600

agcgacatcc tggatgccct gcagagggac cgggggctgg gccggccccg caacaaggcc      660

gaccttcaga gagcgcctgc ccggggaacc cggccccggg gctgtgccac tggctcccgg      720

ccccgagact gtctggacgt cctcctaagc ggacagcagg acgatggcgt ctactctgtc      780

tttcccaccc actacccggc cggcttccag gtgtactgtg acatgcgcac ggacggcggc      840

ggctggacgg tgtttcagcg ccgggaggac ggctccgtga acttcttccg gggctgggat      900

gcgtaccgag acggctttgg caggctcacc ggggagcact ggctagggct caagaggatc      960

cacgccctga ccacacaggc tgcctacgag ctgcacgtgg acctggagga ctttgagaat     1020

ggcacggcct atgcccgcta cgggagcttc ggcgtgggct tgttctccgt ggaccctgag     1080

gaagacgggt acccgctcac cgtggctgac tattccggca ctgcaggcga ctccctcctg     1140

aagcacagcg gcatgaggtt caccaccaag gaccgtgaca gcgaccattc agagaacaac     1200

tgtgccgcct tctaccgcgg tgcctggtgg taccgcaact gccacacgtc caacctcaat     1260

gggcagtacc tgcgcggtgc gcacgcctcc tatgccgacg gcgtggagtg gtcctcctgg     1320

accggctggc agtactcact caagttctct gagatgaaga tccggccggt ccgggaggac     1380

cgctag                                                                1386


<210>  486
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Val Asn Asp Arg Trp Lys Thr Met Gly Gly Ala Ala Gln Leu Glu 
1               5                   10                  15      


Asp Arg Pro Arg Asp Lys Pro Gln Arg Pro Ser Cys Gly Tyr Val Leu 
            20                  25                  30          


Cys Thr Val Leu Leu Ala Leu Ala Val Leu Leu Ala Val Ala Val Thr 
        35                  40                  45              


Gly Ala Val Leu Phe Leu Asn His Ala His Ala Pro Gly Thr Ala Pro 
    50                  55                  60                  


Pro Pro Val Val Ser Thr Gly Ala Ala Ser Ala Asn Ser Ala Leu Val 
65                  70                  75                  80  


Thr Val Glu Arg Ala Asp Ser Ser His Leu Ser Ile Leu Ile Asp Pro 
                85                  90                  95      


Arg Cys Pro Asp Leu Thr Asp Ser Phe Ala Arg Leu Glu Ser Ala Gln 
            100                 105                 110         


Ala Ser Val Leu Gln Ala Leu Thr Glu His Gln Ala Gln Pro Arg Leu 
        115                 120                 125             


Val Gly Asp Gln Glu Gln Glu Leu Leu Asp Thr Leu Ala Asp Gln Leu 
    130                 135                 140                 


Pro Arg Leu Leu Ala Arg Ala Ser Glu Leu Gln Thr Glu Cys Met Gly 
145                 150                 155                 160 


Leu Arg Lys Gly His Gly Thr Leu Gly Gln Gly Leu Ser Ala Leu Gln 
                165                 170                 175     


Ser Glu Gln Gly Arg Leu Ile Gln Leu Leu Ser Glu Ser Gln Gly His 
            180                 185                 190         


Met Ala His Leu Val Asn Ser Val Ser Asp Ile Leu Asp Ala Leu Gln 
        195                 200                 205             


Arg Asp Arg Gly Leu Gly Arg Pro Arg Asn Lys Ala Asp Leu Gln Arg 
    210                 215                 220                 


Ala Pro Ala Arg Gly Thr Arg Pro Arg Gly Cys Ala Thr Gly Ser Arg 
225                 230                 235                 240 


Pro Arg Asp Cys Leu Asp Val Leu Leu Ser Gly Gln Gln Asp Asp Gly 
                245                 250                 255     


Val Tyr Ser Val Phe Pro Thr His Tyr Pro Ala Gly Phe Gln Val Tyr 
            260                 265                 270         


Cys Asp Met Arg Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg 
        275                 280                 285             


Glu Asp Gly Ser Val Asn Phe Phe Arg Gly Trp Asp Ala Tyr Arg Asp 
    290                 295                 300                 


Gly Phe Gly Arg Leu Thr Gly Glu His Trp Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


His Ala Leu Thr Thr Gln Ala Ala Tyr Glu Leu His Val Asp Leu Glu 
                325                 330                 335     


Asp Phe Glu Asn Gly Thr Ala Tyr Ala Arg Tyr Gly Ser Phe Gly Val 
            340                 345                 350         


Gly Leu Phe Ser Val Asp Pro Glu Glu Asp Gly Tyr Pro Leu Thr Val 
        355                 360                 365             


Ala Asp Tyr Ser Gly Thr Ala Gly Asp Ser Leu Leu Lys His Ser Gly 
    370                 375                 380                 


Met Arg Phe Thr Thr Lys Asp Arg Asp Ser Asp His Ser Glu Asn Asn 
385                 390                 395                 400 


Cys Ala Ala Phe Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys His Thr 
                405                 410                 415     


Ser Asn Leu Asn Gly Gln Tyr Leu Arg Gly Ala His Ala Ser Tyr Ala 
            420                 425                 430         


Asp Gly Val Glu Trp Ser Ser Trp Thr Gly Trp Gln Tyr Ser Leu Lys 
        435                 440                 445             


Phe Ser Glu Met Lys Ile Arg Pro Val Arg Glu Asp Arg 
    450                 455                 460     


<210>  487
<211>  1032
<212>  DNA
<213>  Homo sapiens

<400>  487
atgctggcca cccgcctctc cagacccctg tcacggctcc caggaaaaac cctaagtgcc       60

tgtgatagag aaaatggagc aagacgccca ctattgcttg gttctacttc ctttatcccg      120

attggccgtc ggacttatgc cagtgcggcg gagccggttg gcagcaaagc tgtcctggtc      180

acaggctgtg actctggatt tgggttctca ttggccaagc atctgcattc aaaaggcttc      240

cttgtgtttg ctggctgctt gatgaaggac aaaggccatg atggggtcaa ggagctggac      300

agcctaaaca gtgaccgatt gagaaccgtc cagctcaatg tctgcagcag cgaagaggtg      360

gagaaagtgg tggagattgt ccgctcgagc ctgaaggacc ctgagaaagg catgtggggc      420

ctcgttaaca atgccggcat ctcaacgttc ggggaggtgg agttcaccag cctggagacc      480

tacaagcagg tggcagaagt gaacctttgg ggcacagtgc ggatgacgaa atcctttctc      540

cccctcatcc gaagggccaa aggccgcgtc gtcaatatca gcagcatgct gggccgcatg      600

gccaacccgg cccgctcccc gtactgcatc accaagttcg gggtagaggc tttctcggac      660

tgcctgcgct atgagatgta ccccctgggc gtgaaggtca gcgtggtgga gcccggcaac      720

ttcatcgctg ccaccagcct ttacagccct gagagcattc aggccatcgc caagaagatg      780

tgggaggagc tgcctgaggt cgtgcgcaag gactacggca agaagtactt tgatgaaaag      840

atcgccaaga tggagaccta ctgcagcagt ggctccacag acacgtcccc tgtcatcgat      900

gctgtcacac acgccctgac cgccaccacc ccctacaccc gctaccaccc catggactac      960

tactggtggc tgcgaatgca gatcatgacc cacttgcctg gagccatctc cgacatgatc     1020

tacatccgct ga                                                         1032


<210>  488
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Leu Ala Thr Arg Leu Ser Arg Pro Leu Ser Arg Leu Pro Gly Lys 
1               5                   10                  15      


Thr Leu Ser Ala Cys Asp Arg Glu Asn Gly Ala Arg Arg Pro Leu Leu 
            20                  25                  30          


Leu Gly Ser Thr Ser Phe Ile Pro Ile Gly Arg Arg Thr Tyr Ala Ser 
        35                  40                  45              


Ala Ala Glu Pro Val Gly Ser Lys Ala Val Leu Val Thr Gly Cys Asp 
    50                  55                  60                  


Ser Gly Phe Gly Phe Ser Leu Ala Lys His Leu His Ser Lys Gly Phe 
65                  70                  75                  80  


Leu Val Phe Ala Gly Cys Leu Met Lys Asp Lys Gly His Asp Gly Val 
                85                  90                  95      


Lys Glu Leu Asp Ser Leu Asn Ser Asp Arg Leu Arg Thr Val Gln Leu 
            100                 105                 110         


Asn Val Cys Ser Ser Glu Glu Val Glu Lys Val Val Glu Ile Val Arg 
        115                 120                 125             


Ser Ser Leu Lys Asp Pro Glu Lys Gly Met Trp Gly Leu Val Asn Asn 
    130                 135                 140                 


Ala Gly Ile Ser Thr Phe Gly Glu Val Glu Phe Thr Ser Leu Glu Thr 
145                 150                 155                 160 


Tyr Lys Gln Val Ala Glu Val Asn Leu Trp Gly Thr Val Arg Met Thr 
                165                 170                 175     


Lys Ser Phe Leu Pro Leu Ile Arg Arg Ala Lys Gly Arg Val Val Asn 
            180                 185                 190         


Ile Ser Ser Met Leu Gly Arg Met Ala Asn Pro Ala Arg Ser Pro Tyr 
        195                 200                 205             


Cys Ile Thr Lys Phe Gly Val Glu Ala Phe Ser Asp Cys Leu Arg Tyr 
    210                 215                 220                 


Glu Met Tyr Pro Leu Gly Val Lys Val Ser Val Val Glu Pro Gly Asn 
225                 230                 235                 240 


Phe Ile Ala Ala Thr Ser Leu Tyr Ser Pro Glu Ser Ile Gln Ala Ile 
                245                 250                 255     


Ala Lys Lys Met Trp Glu Glu Leu Pro Glu Val Val Arg Lys Asp Tyr 
            260                 265                 270         


Gly Lys Lys Tyr Phe Asp Glu Lys Ile Ala Lys Met Glu Thr Tyr Cys 
        275                 280                 285             


Ser Ser Gly Ser Thr Asp Thr Ser Pro Val Ile Asp Ala Val Thr His 
    290                 295                 300                 


Ala Leu Thr Ala Thr Thr Pro Tyr Thr Arg Tyr His Pro Met Asp Tyr 
305                 310                 315                 320 


Tyr Trp Trp Leu Arg Met Gln Ile Met Thr His Leu Pro Gly Ala Ile 
                325                 330                 335     


Ser Asp Met Ile Tyr Ile Arg 
            340             


<210>  489
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  489
atgcctccct ctgggccccg aggaaccctc cttctgttgc cgctgctgct gctgctcctg       60

cttcgcgccg tgctggctgt ccccctggag cgaggggcgc ccaacaagga ggagacccct      120

gcgactgaga gtcccgacac aggcctgtac taccaccggt acctccagga ggtcatcgat      180

gtactggaga cggatgggca tttccgagag aagctgcagg ctgccaatgc ggaggacatc      240

aagagcggga agctgagccg agagctggac tttgtcagcc accacgtccg caccaagctg      300

gatgagctca agcgacagga ggtgtcacgg ctgcggatgc tgctcaaggc caagatggac      360

gccgagcagg atcccaatgt acaggtggat catctgaatc tcctgaaaca gtttgaacac      420

ctggaccctc agaaccagca tacattcgag gcccgcgacc tggagctgct gatccagacg      480

gccacccggg accttgccca gtacgacgca gcccatcatg aagagttcaa gcgctacgag      540

atgcttaagg aacacgagag acggcgttat ctggagtcac tgggagagga gcagagaaag      600

gaggcggaga ggaagctgga agagcaacag cgccggcacc gcgagcaccc taaagtcaac      660

gtgcctggca gccaagccca gttgaaggag gtgtgggagg agctggatgg actggacccc      720

aacaggttta accccaagac cttcttcata ctgcatgata tcaacagtga tggtgtcctg      780

gatgagcagg agctggaggc actcttcacc aaggagctgg agaaagtgta cgacccaaag      840

aatgaggagg acgacatgcg ggagatggag gaggagcgac tgcgcatgcg ggagcatgtg      900

atgaagaatg tggacaccaa ccaggaccgc ctcgtgaccc tggaggagtt cctcgcatcc      960

actcagagga aggagtttgg ggacaccggg gagggctggg agacagtgga gatgcaccct     1020

gcctacaccg aggaagagct gaggcgcttt gaagaggagc tggctgcccg ggaggcagag     1080

ctgaatgcca aggcccagcg cctcagccag gagacagagg ctctagggcg gtcccagggc     1140

cgcctggagg cccagaagag agagctgcag caggctgtgc tgcacatgga gcagcggaag     1200

cagcagcagc agcagcagca aggccacaag gccccggctg cccaccctga ggggcagctc     1260

aagttccacc cagacacaga cgatgtacct gtcccagctc cagccggtga ccagaaggag     1320

gtggacactt cagaaaagaa acttctcgag cggctccctg aggttgaggt gccccagcat     1380

ctgtga                                                                1386


<210>  490
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  491
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  491
atgctgcccc tctgcctcgt ggccgccctg ctgctggccg ccgggcccgg gccgagcctg       60

ggcgacgaag ccatccactg cccgccctgc tccgaggaga agctggcgcg ctgccgcccc      120

cccgtgggct gcgaggagct ggtgcgagag ccgggctgcg gctgttgcgc cacttgcgcc      180

ctgggcttgg ggatgccctg cggggtgtac accccccgtt gcggctcggg cctgcgctgc      240

tacccgcccc gaggggtgga gaagcccctg cacacactga tgcacgggca aggcgtgtgc      300

atggagctgg cggagatcga ggccatccag gaaagcctgc agccctctga caaggacgag      360

ggtgaccacc ccaacaacag cttcagcccc tgtagcgccc atgaccgcag gtgcctgcag      420

aagcacttcg ccaaaattcg agaccggagc accagtgggg gcaagatgaa ggtcaatggg      480

gcgccccggg aggatgcccg gcctgtgccc cagggctcct gccagagcga gctgcaccgg      540

gcgctggagc ggctggccgc ttcacagagc cgcacccacg aggacctcta catcatcccc      600

atccccaact gcgaccgcaa cggcaacttc caccccaagc agtgtcaccc agctctggat      660

gggcagcgtg gcaagtgctg gtgtgtggac cggaagacgg gggtgaagct tccggggggc      720

ctggagccaa agggggagct ggactgccac cagctggctg acagctttcg agagtga         777


<210>  492
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210>  493
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  493
atgctattca aacagcaggc gtggctgaga cagaagctcc tggtgctggg aagccttgcc       60

gttgggagtc tcctgtatct agtcgccaga gttgggagct tggataggct acaacccatt      120

tgccccattg aaggtcgact gggtggagcc cgcactcagg ctgaattccc acttcgcgcc      180

ctgcagttta agcgtggcct gctgcacgag ttccggaagg gcaacgcttc caaggagcag      240

gttcgcctcc atgacctggt ccagcagctc cccaaggcca ttatcattgg ggtgaggaaa      300

ggaggcacaa gggccctgct tgaaatgctg aacctacatc cggcagtagt caaagcctct      360

caagaaatcc acttttttga taatgatgag aattatggta agggcattga gtggtatagg      420

aaaaagatgc ctttttccta ccctcagcaa atcacaattg aaaagagccc agcatatttt      480

atcacagagg aggttccaga aaggatttac aaaatgaact catccatcaa gttgttgatc      540

attgtcaggg agccaaccac aagagctatt tctgattata ctcaggtgct agaggggaag      600

gagaggaaga acaaaactta ttacaagttt gagaagctgg ccatagaccc taatacatgc      660

gaagtgaaca caaaatacaa agcagtaaga accagcatct acaccaaaca tctggaaagg      720

tggttgaaat actttccaat tgagcaattt catgtcgtcg atggagatcg cctcatcacg      780

gaacctctgc cagaacttca gctcgtggag aagttcctaa atctgcctcc aaggataagt      840

caatacaatt tatacttcaa tgctaccaga gggttttact gcttgcggtt taatattatc      900

tttaataagt gcctggcggg cagcaagggg cgcattcatc cagaggtgga cccctctgtc      960

attactaaat tgcgcaaatt ctttcatcct tttaatcaaa aattttacca gatcactggg     1020

aggacattga actggcccta a                                               1041


<210>  494
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Leu Phe Lys Gln Gln Ala Trp Leu Arg Gln Lys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ser Leu Ala Val Gly Ser Leu Leu Tyr Leu Val Ala Arg Val Gly 
            20                  25                  30          


Ser Leu Asp Arg Leu Gln Pro Ile Cys Pro Ile Glu Gly Arg Leu Gly 
        35                  40                  45              


Gly Ala Arg Thr Gln Ala Glu Phe Pro Leu Arg Ala Leu Gln Phe Lys 
    50                  55                  60                  


Arg Gly Leu Leu His Glu Phe Arg Lys Gly Asn Ala Ser Lys Glu Gln 
65                  70                  75                  80  


Val Arg Leu His Asp Leu Val Gln Gln Leu Pro Lys Ala Ile Ile Ile 
                85                  90                  95      


Gly Val Arg Lys Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Asn Leu 
            100                 105                 110         


His Pro Ala Val Val Lys Ala Ser Gln Glu Ile His Phe Phe Asp Asn 
        115                 120                 125             


Asp Glu Asn Tyr Gly Lys Gly Ile Glu Trp Tyr Arg Lys Lys Met Pro 
    130                 135                 140                 


Phe Ser Tyr Pro Gln Gln Ile Thr Ile Glu Lys Ser Pro Ala Tyr Phe 
145                 150                 155                 160 


Ile Thr Glu Glu Val Pro Glu Arg Ile Tyr Lys Met Asn Ser Ser Ile 
                165                 170                 175     


Lys Leu Leu Ile Ile Val Arg Glu Pro Thr Thr Arg Ala Ile Ser Asp 
            180                 185                 190         


Tyr Thr Gln Val Leu Glu Gly Lys Glu Arg Lys Asn Lys Thr Tyr Tyr 
        195                 200                 205             


Lys Phe Glu Lys Leu Ala Ile Asp Pro Asn Thr Cys Glu Val Asn Thr 
    210                 215                 220                 


Lys Tyr Lys Ala Val Arg Thr Ser Ile Tyr Thr Lys His Leu Glu Arg 
225                 230                 235                 240 


Trp Leu Lys Tyr Phe Pro Ile Glu Gln Phe His Val Val Asp Gly Asp 
                245                 250                 255     


Arg Leu Ile Thr Glu Pro Leu Pro Glu Leu Gln Leu Val Glu Lys Phe 
            260                 265                 270         


Leu Asn Leu Pro Pro Arg Ile Ser Gln Tyr Asn Leu Tyr Phe Asn Ala 
        275                 280                 285             


Thr Arg Gly Phe Tyr Cys Leu Arg Phe Asn Ile Ile Phe Asn Lys Cys 
    290                 295                 300                 


Leu Ala Gly Ser Lys Gly Arg Ile His Pro Glu Val Asp Pro Ser Val 
305                 310                 315                 320 


Ile Thr Lys Leu Arg Lys Phe Phe His Pro Phe Asn Gln Lys Phe Tyr 
                325                 330                 335     


Gln Ile Thr Gly Arg Thr Leu Asn Trp Pro 
            340                 345     


<210>  495
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  495
atgtcggagg agagcgacat ggacaaagcc atcaaggaaa cttccatttt agaagaatac       60

agtatcaatt ggactcagaa gctgggagct ggaattagtg gtccagttag agtctgtgta      120

aagaaatcta ctcaagaacg gtttgcgctg aaaattcttc ttgatcgtcc aaaagctaga      180

aatgaggtac gtctgcacat gatgtgtgcc acacacccaa acatagttca gattattgaa      240

gtgtttgcta acagtgtcca gtttccccat gagtccagcc ctagggcccg actcttaatt      300

gtaatggaga tgatggaagg gggagagcta tttcacagaa tcagccagca ccggcacttt      360

acagagaagc aagccagcca agtaacaaag cagatagctt tggctctgcg gcactgtcac      420

ttgttaaaca ttgcgcacag agacctcaag cctgaaaatc tgctttttaa ggataactct      480

ttggatgccc cagtgaagtt gtgtgacttt ggatttgcca agattgacca aggtgacttg      540

atgacacccc agttcacccc ttattatgta gcaccccagg tactggaggc gcaaagaagg      600

catcagaagg agaaatctgg catcatacct acctcaccga cgccctacac ttacaacaag      660

agctgtgact tgtggtccct aggggtgatt atctatgtga tgctgtgcgg ataccctcct      720

ttttactcca aacaccacag ccggactatc ccaaaggata tgcgaagaaa gatcatgaca      780

ggcagttttg agttcccaga ggaagagtgg agtcagatct cagagatggc caaagatgtt      840

gtgaggaagc tcctgaaggt caaaccggag gagagactca ccatcgaggg agtgctggac      900

cacccctggc tcaattccac cgaggccctg gataatgtgc tgccttctgc tcagctgatg      960

atggacaagg cagtggttgc aggaatccag caggctcacg cggaacagtt ggccaacatg     1020

agaatccagg atctgaaagt cagcctcaaa cccctgcact cagtgaacaa ccccattctg     1080

cggaagagga agttacttgg caccaagcca aaggacagtg tctatatcca cgaccatgag     1140

aatggagccg aggattccaa tgttgccttg gaaaaactcc gagatgtgat tgctcagtgt     1200

attctccccc aggctggaga gaatgaagat gagaaactga atgaagtaat gcaggaggct     1260

tggaagtata accgggaatg caaactccta agagatactc tgcagagctt cagctggaat     1320

ggtcgtggat tcacagataa agtagatcga ctaaaactgg cagaaattgt gaagcaggtg     1380

atagaagagc aaaccacgtc ccacgaatcc caataa                               1416


<210>  496
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Ser Glu Glu Ser Asp Met Asp Lys Ala Ile Lys Glu Thr Ser Ile 
1               5                   10                  15      


Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu Gly Ala Gly Ile 
            20                  25                  30          


Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr Gln Glu Arg Phe 
        35                  40                  45              


Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg Asn Glu Val Arg 
    50                  55                  60                  


Leu His Met Met Cys Ala Thr His Pro Asn Ile Val Gln Ile Ile Glu 
65                  70                  75                  80  


Val Phe Ala Asn Ser Val Gln Phe Pro His Glu Ser Ser Pro Arg Ala 
                85                  90                  95      


Arg Leu Leu Ile Val Met Glu Met Met Glu Gly Gly Glu Leu Phe His 
            100                 105                 110         


Arg Ile Ser Gln His Arg His Phe Thr Glu Lys Gln Ala Ser Gln Val 
        115                 120                 125             


Thr Lys Gln Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile 
    130                 135                 140                 


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser 
145                 150                 155                 160 


Leu Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp 
                165                 170                 175     


Gln Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro 
            180                 185                 190         


Gln Val Leu Glu Ala Gln Arg Arg His Gln Lys Glu Lys Ser Gly Ile 
        195                 200                 205             


Ile Pro Thr Ser Pro Thr Pro Tyr Thr Tyr Asn Lys Ser Cys Asp Leu 
    210                 215                 220                 


Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr Pro Pro 
225                 230                 235                 240 


Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met Arg Arg 
                245                 250                 255     


Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp Ser Gln 
            260                 265                 270         


Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys Val Lys 
        275                 280                 285             


Pro Glu Glu Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro Trp Leu 
    290                 295                 300                 


Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln Leu Met 
305                 310                 315                 320 


Met Asp Lys Ala Val Val Ala Gly Ile Gln Gln Ala His Ala Glu Gln 
                325                 330                 335     


Leu Ala Asn Met Arg Ile Gln Asp Leu Lys Val Ser Leu Lys Pro Leu 
            340                 345                 350         


His Ser Val Asn Asn Pro Ile Leu Arg Lys Arg Lys Leu Leu Gly Thr 
        355                 360                 365             


Lys Pro Lys Asp Ser Val Tyr Ile His Asp His Glu Asn Gly Ala Glu 
    370                 375                 380                 


Asp Ser Asn Val Ala Leu Glu Lys Leu Arg Asp Val Ile Ala Gln Cys 
385                 390                 395                 400 


Ile Leu Pro Gln Ala Gly Glu Asn Glu Asp Glu Lys Leu Asn Glu Val 
                405                 410                 415     


Met Gln Glu Ala Trp Lys Tyr Asn Arg Glu Cys Lys Leu Leu Arg Asp 
            420                 425                 430         


Thr Leu Gln Ser Phe Ser Trp Asn Gly Arg Gly Phe Thr Asp Lys Val 
        435                 440                 445             


Asp Arg Leu Lys Leu Ala Glu Ile Val Lys Gln Val Ile Glu Glu Gln 
    450                 455                 460                 


Thr Thr Ser His Glu Ser Gln 
465                 470     


<210>  497
<211>  2532
<212>  DNA
<213>  Homo sapiens

<400>  497
atgaaggtga taagcttatt cattttggtg ggatttatag gagagttcca aagtttttca       60

agtgcctcct ctccagtcaa ctgccagtgg gacttctatg ccccttggtc agaatgcaat      120

ggctgtacca agactcagac tcgcaggcgg tcagttgctg tgtatgggca gtatggaggc      180

cagccttgtg ttggaaatgc ttttgaaaca cagtcctgtg aacctacaag aggatgtcca      240

acagaggagg gatgtggaga gcgtttcagg tgcttttcag gtcagtgcat cagcaaatca      300

ttggtttgca atggggattc tgactgtgat gaagacagtg ctgatgaaga cagatgtgag      360

gactcagaaa ggagaccttc ctgtgatatc gataaacctc ctcctaacat agaacttact      420

ggaaatggtt acaatgaact cactggccag tttaggaaca gagtcatcaa taccaaaagt      480

tttggtggtc aatgtagaaa ggtgtttagt ggggatggaa aagatttcta caggctgagt      540

ggaaatgtcc tgtcctatac attccaggtg aaaataaata atgattttaa ttatgaattt      600

tacaatagta cttggtctta tgtaaaacat acgtcgacag aacacacatc atctagtcgg      660

aagcgctcct tttttagatc ttcatcatct tcttcacgca gttatacttc acataccaat      720

gaaatccata aaggaaagag ttaccaactg ctggttgttg agaacactgt tgaagtggct      780

cagttcatta ataacaatcc agaattttta caacttgctg agccattctg gaaggagctt      840

tcccacctcc cctctctgta tgactacagt gcctaccgaa gattaatcga ccagtacggg      900

acacattatc tgcaatctgg gtcgttagga ggagaataca gagttctatt ttatgtggac      960

tcagaaaaat taaaacaaaa tgattttaat tcagtcgaag aaaagaaatg taaatcctca     1020

ggttggcatt ttgtcgttaa attttcaagt catggatgca aggaactgga aaacgcttta     1080

aaagctgctt caggaaccca gaacaatgta ttgcgaggag aaccgttcat cagaggggga     1140

ggtgcaggct tcatatctgg ccttagttac ctagagctgg acaatcctgc tggaaacaaa     1200

aggcgatatt ctgcctgggc agaatctgtg actaatcttc ctcaagtcat aaaacaaaag     1260

ctgacacctt tatatgagct ggtaaaggaa gtaccttgtg cctctgtgaa aaaactatac     1320

ctgaaatggg ctcttgaaga gtatctggat gaatttgacc cctgtcattg ccggccttgt     1380

caaaatggtg gtttggctac tgttgagggg acccattgtc tgtgccattg caaaccgtac     1440

acatttggtg cggcgtgtga gcaaggagtc ctcgtaggga atcaagcagg aggggttgat     1500

ggaggttgga gttgctggtc ctcttggagc ccctgtgtcc aagggaagaa aacaagaagc     1560

cgtgaatgca ataacccacc tcccagtggg ggtgggagat cctgcgttgg agaaacgaca     1620

gaaagcacac aatgcgaaga tgaggagctg gagcacttga ggttgcttga accacattgc     1680

tttcctttgt ctttggttcc aacagaattc tgtccatcac ctcctgcctt gaaagatgga     1740

tttgttcaag atgaaggtac aatgtttcct gtggggaaaa atgtagtgta cacttgcaat     1800

gaaggatact ctcttattgg aaacccagtg gccagatgtg gagaagattt acggtggctt     1860

gttggggaaa tgcattgtca gaaaattgcc tgtgttctac ctgtactgat ggatggcata     1920

cagagtcacc cccaaaaacc tttctacaca gttggtgaga aggtgactgt ttcctgttca     1980

ggtggcatgt ccttagaagg tccttcagca tttctctgtg gctccagcct taagtggagt     2040

cctgagatga agaatgcccg ctgtgtacaa aaagaaaatc cgttaacaca ggcagtgcct     2100

aaatgtcagc gctgggagaa actgcagaat tcaagatgtg tttgtaaaat gccctacgaa     2160

tgtggacctt ccttggatgt atgtgctcaa gatgagagaa gcaaaaggat actgcctctg     2220

acagtttgca agatgcatgt tctccactgt cagggtagaa attacaccct tactggtagg     2280

gacagctgta ctctgcctgc ctcagctgag aaagcttgtg gtgcctgccc actgtgggga     2340

aaatgtgatg ctgagagcag caaatgtgtc tgccgagaag catcggagtg cgaggaagaa     2400

gggtttagca tttgtgtgga agtgaacggc aaggagcaga cgatgtctga gtgtgaggcg     2460

ggcgctctga gatgcagagg gcagagcatc tctgtcacca gcataaggcc ttgtgctgcg     2520

gaaacccagt ag                                                         2532


<210>  498
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210>  499
<211>  4338
<212>  DNA
<213>  Homo sapiens

<400>  499
atgcggaggt tactggaacc gtgttggtgg attttgttcc tgaaaatcac cagttccgtg       60

ctccattatg tcgtgtgctt ccccgcgttg acagaaggct acgttggggc cctgcacgag      120

aatagacacg gcagcgcagt gcagatccgc aggcgcaagg cttcaggcga cccgtactgg      180

gcctactctg gtgcctatgg tcctgagcac tgggtcacgt ctagtgtcag ctgtgggggc      240

cgtcaccagt ctcctattga cattttagac cagtatgcgc gtgttgggga agaataccag      300

gaactgcaac tcgatggctt cgacaatgag tcttctaaca aaacctggat gaaaaacaca      360

gggaaaacag tcgccatcct tctgaaagac gactattttg tcagtggagc tggtctacct      420

ggcagattca aagctgagaa ggtggaattt cactggggcc acagcaatgg ctcagcgggc      480

tctgaacaca gcatcaatgg caggaggttt cctgttgaga tgcagatttt cttttacaat      540

ccagatgact ttgacagctt tcaaaccgca atttctgaga acagaataat cggagccatg      600

gccatatttt ttcaagtcag tccgagggac aattctgcac tggatcctat tatccacggg      660

ttgaagggtg tcgtacatca tgagaaggag acctttctgg atcctttcgt cctccgggac      720

ctcctgcctg catccctggg cagctattat cggtacacag gttccttgac cacaccaccg      780

tgtagcgaaa tagtggagtg gatagtcttc cggagacccg tccccatctc ttaccatcag      840

cttgaggctt tttattccat cttcaccacg gagcagcaag accatgtcaa gtcggtggag      900

tatctgagaa ataactttcg accacagcag cgtctgcatg acagggtggt gtccaagtcc      960

gccgtccgtg actcctggaa ccacgacatg acagacttct tagaaaaccc actggggaca     1020

gaagcctcta aagtttgcag ctctccaccc atccacatga aggtgcagcc tctgaaccag     1080

acggcactgc aggtgtcctg gagccagccg gagactatct accacccacc catcatgaac     1140

tacatgatct cctacagctg gaccaagaat gaggacgaga aggagaagac gtttacaaag     1200

gacagcgaca aagacttgaa agccaccatt agccatgtct cacccgatag cctttacctg     1260

ttccgagtcc aggccgtgtg tcggaacgac atgcgcagcg actttagcca gacgatgctg     1320

tttcaagcta ataccactcg aatattccaa gggaccagaa tagtgaaaac aggagtgccc     1380

acagcgtctc ctgcctcttc agccgacatg gcccccatca gctcggggtc ttctacctgg     1440

acgtcctctg gcatcccatt ctcatttgtt tccatggcaa ctgggatggg cccctcctcc     1500

agtggcagcc aggccacagt ggcctcggtg gtcaccagca cgctgctcgc cggcctgggg     1560

ttcggcggtg gtggcatctc ctctttcccc agcactgtgt ggcccacgcg cctcccgacg     1620

gccgcctcag ccagcaagca ggcggctagg ccagtcctag ccaccacaga ggccttggct     1680

tctccagggc ccgatggtga ttcgtcacca accaaggacg gcgagggcac cgaggaagga     1740

gagaaggatg agaaaagcga gagtgaggat ggggagcggg agcacgagga ggatggagag     1800

aaggactccg aaaagaagga gaagagtggg gtgacccacg ctgccgagga gcggaatcag     1860

acggagccca gccccacacc ctcgtctcct aacaggactg ccgagggagg gcatcagact     1920

atacctgggc atgagcagga tcacactgcc gtccccacag accagacggg cggaaggagg     1980

gatgccggcc caggcctgga ccccgacatg gtcacctcca cccaagtgcc ccccaccgcc     2040

acagaggagc agtatgcagg gagtgatccc aagaggcccg aaatgccatc taaaaagcct     2100

atgtcccgcg gggaccgatt ttctgaagac agcagattta tcactgttaa tccagcggaa     2160

aaaaacacct ctggaatgat aagccgccct gctccaggga ggatggagtg gatcatccct     2220

ctgattgtgg tatcagcctt gaccttcgtg tgcctcatcc ttctcattgc tgtgctcgtt     2280

tactggagag ggtgtaacaa aataaagtcc aagggctttc ccagacgttt ccgtgaagtg     2340

ccttcttctg gggagagagg agagaagggg agcagaaaat gttttcagac tgctcatttc     2400

tatgtggaag acagcagttc acctcgagtg gtccctaatg aaagtatccc tattattcct     2460

attccggatg acatggaagc cattcctgtc aaacagtttg tcaaacacat cggtgagctc     2520

tattctaata accagcatgg gttctctgag gattttgagg aagtccagcg ctgtactgct     2580

gatatgaaca tcactgcaga gcattccaat catccagaaa acaagcacaa aaacagatac     2640

atcaacattt tagcatatga tcacagtagg gtgaagttaa gacctttacc aggaaaagac     2700

tctaagcaca gcgactacat taatgcaaac tatgttgatg gttacaacaa agcaaaagcc     2760

tacattgcca cccaaggacc tttgaagtct acatttgaag atttctggag gatgatttgg     2820

gaacaaaaca ctggaatcat tgtgatgatt acgaaccttg tggaaaaagg aagacgaaaa     2880

tgtgatcagt attggccaac agagaacagt gaggaatatg gaaacattat tgtcacgctg     2940

aagagcacaa aaatacatgc ctgctacact gttcgtcgtt tttcaatcag aaatacaaaa     3000

gtgaaaaagg gtcagaaggg aaatcccaag ggtcgtcaga atgaaagggt agtgatccag     3060

tatcactata cacagtggcc tgacatggga gttcccgagt atgcccttcc agtactgact     3120

ttcgtgagga gatcctcagc agctcggatg ccagaaacgg gccctgtgtt ggtgcactgc     3180

agtgctggtg tgggcagaac aggcacctat attgtaatag acagcatgct gcaacagata     3240

aaagacaaaa gcacagttaa cgtcctggga ttcctgaagc atatcaggac acagcgtaac     3300

tacctcgtcc agactgagga gcagtacatt ttcatccatg atgccttgtt ggaagccatt     3360

cttggaaagg agactgaagt atcttcaaat cagctgcaca gctatgttaa cagcatcctt     3420

ataccaggag taggaggaaa gacacgactg gaaaagcaat tcaagctggt cacacagtgt     3480

aatgcaaaat atgtggaatg tttcagtgct cagaaagagt gtaacaaaga aaagaacaga     3540

aactcttcag ttgtgccatc tgagcgtgct cgagtgggtc ttgcaccatt gcctggaatg     3600

aaaggaacag attacattaa tgcttcttat atcatgggct attataggag caatgaattt     3660

attataactc agcatcctct gccacatact acgaaagatt tctggcgaat gatttgggat     3720

cataacgcac agatcattgt catgctgcca gacaaccaga gcttggcaga agatgagttt     3780

gtgtactggc caagtcgaga agaatccatg aactgtgagg cctttaccgt cacccttatc     3840

agcaaagaca gactgtgcct ctctaatgaa gaacaaatta tcatccatga ctttatcctt     3900

gaagctacac aggatgacta tgtcttagaa gttcggcact ttcagtgtcc caaatggcct     3960

aacccagatg cccccataag tagtaccttt gaacttatca acgtcatcaa ggaagaggcc     4020

ttaacaaggg atggtcccac cattgttcat gatgagtatg gagcagtttc agcaggaatg     4080

ttatgtgccc ttaccaccct gtcccagcaa ctggagaatg aaaatgctgt ggatgttttc     4140

caggttgcaa aaatgatcaa tcttatgagg cctggagtat tcacagacat tgaacaatac     4200

cagttcatct ataaagcaat gcttagcttg gtcagcacta aagaaaatgg aaatggtccc     4260

atgacagtag acaaaaatgg tgctgttctt attgcagatg aatcagaccc tgctgagagc     4320

atggagtccc tagtgtga                                                   4338


<210>  500
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765             


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780                 


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800 


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815     


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830         


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845             


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860                 


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880 


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895     


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910         


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925             


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940                 


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960 


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975     


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990         


Arg Phe Ser Ile Arg Asn Thr Lys  Val Lys Lys Gly Gln  Lys Gly Asn 
        995                 1000                 1005             


Pro Lys  Gly Arg Gln Asn Glu  Arg Val Val Ile Gln  Tyr His Tyr 
    1010                 1015                 1020             


Thr Gln  Trp Pro Asp Met Gly  Val Pro Glu Tyr Ala  Leu Pro Val 
    1025                 1030                 1035             


Leu Thr  Phe Val Arg Arg Ser  Ser Ala Ala Arg Met  Pro Glu Thr 
    1040                 1045                 1050             


Gly Pro  Val Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1055                 1060                 1065             


Thr Tyr  Ile Val Ile Asp Ser  Met Leu Gln Gln Ile  Lys Asp Lys 
    1070                 1075                 1080             


Ser Thr  Val Asn Val Leu Gly  Phe Leu Lys His Ile  Arg Thr Gln 
    1085                 1090                 1095             


Arg Asn  Tyr Leu Val Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1100                 1105                 1110             


Asp Ala  Leu Leu Glu Ala Ile  Leu Gly Lys Glu Thr  Glu Val Ser 
    1115                 1120                 1125             


Ser Asn  Gln Leu His Ser Tyr  Val Asn Ser Ile Leu  Ile Pro Gly 
    1130                 1135                 1140             


Val Gly  Gly Lys Thr Arg Leu  Glu Lys Gln Phe Lys  Leu Val Thr 
    1145                 1150                 1155             


Gln Cys  Asn Ala Lys Tyr Val  Glu Cys Phe Ser Ala  Gln Lys Glu 
    1160                 1165                 1170             


Cys Asn  Lys Glu Lys Asn Arg  Asn Ser Ser Val Val  Pro Ser Glu 
    1175                 1180                 1185             


Arg Ala  Arg Val Gly Leu Ala  Pro Leu Pro Gly Met  Lys Gly Thr 
    1190                 1195                 1200             


Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly Tyr Tyr  Arg Ser Asn 
    1205                 1210                 1215             


Glu Phe  Ile Ile Thr Gln His  Pro Leu Pro His Thr  Thr Lys Asp 
    1220                 1225                 1230             


Phe Trp  Arg Met Ile Trp Asp  His Asn Ala Gln Ile  Ile Val Met 
    1235                 1240                 1245             


Leu Pro  Asp Asn Gln Ser Leu  Ala Glu Asp Glu Phe  Val Tyr Trp 
    1250                 1255                 1260             


Pro Ser  Arg Glu Glu Ser Met  Asn Cys Glu Ala Phe  Thr Val Thr 
    1265                 1270                 1275             


Leu Ile  Ser Lys Asp Arg Leu  Cys Leu Ser Asn Glu  Glu Gln Ile 
    1280                 1285                 1290             


Ile Ile  His Asp Phe Ile Leu  Glu Ala Thr Gln Asp  Asp Tyr Val 
    1295                 1300                 1305             


Leu Glu  Val Arg His Phe Gln  Cys Pro Lys Trp Pro  Asn Pro Asp 
    1310                 1315                 1320             


Ala Pro  Ile Ser Ser Thr Phe  Glu Leu Ile Asn Val  Ile Lys Glu 
    1325                 1330                 1335             


Glu Ala  Leu Thr Arg Asp Gly  Pro Thr Ile Val His  Asp Glu Tyr 
    1340                 1345                 1350             


Gly Ala  Val Ser Ala Gly Met  Leu Cys Ala Leu Thr  Thr Leu Ser 
    1355                 1360                 1365             


Gln Gln  Leu Glu Asn Glu Asn  Ala Val Asp Val Phe  Gln Val Ala 
    1370                 1375                 1380             


Lys Met  Ile Asn Leu Met Arg  Pro Gly Val Phe Thr  Asp Ile Glu 
    1385                 1390                 1395             


Gln Tyr  Gln Phe Ile Tyr Lys  Ala Met Leu Ser Leu  Val Ser Thr 
    1400                 1405                 1410             


Lys Glu  Asn Gly Asn Gly Pro  Met Thr Val Asp Lys  Asn Gly Ala 
    1415                 1420                 1425             


Val Leu  Ile Ala Asp Glu Ser  Asp Pro Ala Glu Ser  Met Glu Ser 
    1430                 1435                 1440             


Leu Val  
    1445 


<210>  501
<211>  1263
<212>  DNA
<213>  Homo sapiens

<400>  501
atgctgcccg ggctcaggcg cctgctgcaa gctcccgcct cggcctgcct cctgctgatg       60

ctcctggccc tgcccctggc ggcccccagc tgccccatgc tctgcacctg ctactcatcc      120

ccgcccaccg tgagctgcca ggccaacaac ttctcctctg tgccgctgtc cctgccaccc      180

agcactcagc gactcttcct gcagaacaac ctcatccgca cgctgcggcc aggcaccttt      240

gggtccaacc tgctcaccct gtggctcttc tccaacaacc tctccaccat ctacccgggc      300

actttccgcc acttgcaagc cctggaggag ctggacctcg gtgacaaccg gcacctgcgc      360

tcgctggagc ccgacacctt ccagggcctg gagcggctgc agtcgctgca tttgtaccgc      420

tgccagctca gcagcctgcc cggcaacatc ttccgaggcc tggtcagcct gcagtacctc      480

tacctccagg agaacagcct gctccaccta caggatgact tgttcgcgga cctggccaac      540

ctgagccacc tcttcctcca cgggaaccgc ctgcggctgc tcacagagca cgtgtttcgc      600

ggcctgggca gcctggaccg gctgctgctg cacgggaacc ggctgcaggg cgtgcaccgc      660

gcggccttcc gcggcctcag ccgcctcacc atcctctacc tgttcaacaa cagcctggcc      720

tcgctgcccg gcgaggcgct cgccgacctg ccctcgctcg agttcctgcg gctcaacgct      780

aacccctggg cgtgcgactg ccgcgcgcgg ccgctctggg cctggttcca gcgcgcgcgc      840

gtgtccagct ccgacgtgac ctgcgccacc cccccggagc gccagggccg agacctgcgc      900

gcgctccgcg aggccgactt ccaggcgtgt ccgcccgcgg cacccacgcg gccgggcagc      960

cgcgcccgcg gcaacagctc ctccaaccac ctgtacgggg tggccgaggc cggggcgccc     1020

ccagccgatc cctccaccct ctaccgagat ctgcctgccg aagactcgcg ggggcgccag     1080

ggcggggacg cgcctactga ggacgactac tgggggggct acgggggtga ggaccagcga     1140

ggggagcaga tgtgccccgg cgctgcctgc caggcgcccc cggactcccg aggccctgcg     1200

ctctcggccg ggctccccag ccctctgctt tgcctcctgc tcctggtgcc ccaccacctc     1260

tga                                                                   1263


<210>  502
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys 
1               5                   10                  15      


Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro 
            20                  25                  30          


Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala 
        35                  40                  45              


Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg 
    50                  55                  60                  


Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe 
65                  70                  75                  80  


Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr 
                85                  90                  95      


Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp 
            100                 105                 110         


Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln 
        115                 120                 125             


Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser 
    130                 135                 140                 


Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu 
145                 150                 155                 160 


Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala 
                165                 170                 175     


Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg 
            180                 185                 190         


Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu 
        195                 200                 205             


Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg 
    210                 215                 220                 


Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala 
225                 230                 235                 240 


Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu 
                245                 250                 255     


Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu 
            260                 265                 270         


Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys 
        275                 280                 285             


Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu 
    290                 295                 300                 


Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser 
305                 310                 315                 320 


Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu 
                325                 330                 335     


Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro 
            340                 345                 350         


Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp 
        355                 360                 365             


Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met 
    370                 375                 380                 


Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala 
385                 390                 395                 400 


Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val 
                405                 410                 415     


Pro His His Leu 
            420 


<210>  503
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  503
atgtattcca atgtgatagg aactgtaacc tctggaaaaa ggaaggttta tcttttgtcc       60

ttgctgctca ttggcttctg ggactgcgtg acctgtcacg ggagccctgt ggacatctgc      120

acagccaagc cgcgggacat tcccatgaat cccatgtgca tttaccgctc cccggagaag      180

aaggcaactg aggatgaggg ctcagaacag aagatcccgg aggccaccaa ccggcgtgtc      240

tgggaactgt ccaaggccaa ttcccgcttt gctaccactt tctatcagca cctggcagat      300

tccaagaatg acaatgataa cattttcctg tcacccctga gtatctccac ggcttttgct      360

atgaccaagc tgggtgcctg taatgacacc ctccagcaac tgatggaggt atttaagttt      420

gacaccatat ctgagaaaac atctgatcag atccacttct tctttgccaa actgaactgc      480

cgactctatc gaaaagccaa caaatcctcc aagttagtat cagccaatcg cctttttgga      540

gacaaatccc ttaccttcaa tgagacctac caggacatca gtgagttggt atatggagcc      600

aagctccagc ccctggactt caaggaaaat gcagagcaat ccagagcggc catcaacaaa      660

tgggtgtcca ataagaccga aggccgaatc accgatgtca ttccctcgga agccatcaat      720

gagctcactg ttctggtgct ggttaacacc atttacttca agggcctgtg gaagtcaaag      780

ttcagccctg agaacacaag gaaggaactg ttctacaagg ctgatggaga gtcgtgttca      840

gcatctatga tgtaccagga aggcaagttc cgttatcggc gcgtggctga aggcacccag      900

gtgcttgagt tgcccttcaa aggtgatgac atcaccatgg tcctcatctt gcccaagcct      960

gagaagagcc tggccaaggt agagaaggaa ctcaccccag aggtgctgca agagtggctg     1020

gatgaattgg aggagatgat gctggtggtc cacatgcccc gcttccgcat tgaggacggc     1080

ttcagtttga aggagcagct gcaagacatg ggccttgtcg atctgttcag ccctgaaaag     1140

tccaaactcc caggtattgt tgcagaaggc cgagatgacc tctatgtctc agatgcattc     1200

cataaggcat ttcttgaggt aaatgaagaa ggcagtgaag cagctgcaag taccgctgtt     1260

gtgattgctg gccgttcgct aaaccccaac agggtgactt tcaaggccaa caggcctttc     1320

ctggttttta taagagaagt tcctctgaac actattatct tcatgggcag agtagccaac     1380

ccttgtgtta agtaa                                                      1395


<210>  504
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
        35                  40                  45              


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
    50                  55                  60                  


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
65                  70                  75                  80  


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
                85                  90                  95      


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
        115                 120                 125             


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
    130                 135                 140                 


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
                165                 170                 175     


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
            180                 185                 190         


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
        195                 200                 205             


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
    210                 215                 220                 


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
225                 230                 235                 240 


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
                245                 250                 255     


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
            260                 265                 270         


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
        275                 280                 285             


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
    290                 295                 300                 


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
305                 310                 315                 320 


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
                325                 330                 335     


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
            340                 345                 350         


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
        355                 360                 365             


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
    370                 375                 380                 


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
385                 390                 395                 400 


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
                405                 410                 415     


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
            420                 425                 430         


Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro 
        435                 440                 445             


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
    450                 455                 460                 


<210>  505
<211>  3564
<212>  DNA
<213>  Homo sapiens

<400>  505
atgccttttg gtctgaagct ccgccggaca cggcgctaca acgtcctgag caagaactgc       60

tttgtcacac ggattcgcct gctggacagc aatgttatcg agtgcacgct gtcggtggaa      120

agcacagggc aagaatgcct ggaggctgtg gcccagaggc tggagctgcg agagacgcac      180

tactttggcc tttggtttct cagcaagagc cagcaagcac gatgggtgga gctggagaaa      240

cctctgaaga aacatctgga caaattcgct aatgagcctt tgcttttctt tggagtcatg      300

ttctatgtgc caaatgtgtc atggcttcag caagaggcca caagatatca gtattacctg      360

caagtcaaaa aagatgtgct tgaagggcga ttacgatgta cattggacca ggtgattcgg      420

ctagccggcc tagctgtgca agctgatttt ggagactata atcagtttga ttctcaagat      480

ttcctcagag agtatgtgct atttcctatg gatttggccc tggaagaggc tgttctggag      540

gagctgaccc agaaggtagc ccaagaacac aaagcccaca gtggaatcct gccagcagaa      600

gctgaactga tgtacatcaa tgaagttgaa cgtttggatg gatttggaca ggaaatcttc      660

cctgtaaagg acaatcatgg aaactgtgta caccttggca ttttctttat ggggattttc      720

gtgaggaaca gaattggaag acaagcggta atatacaggt ggaatgacat ggggaatatc      780

actcataaca agtcgaccat tctagtggag ctcatcaaca aagaagagac tgccctcttt      840

cacacggatg atatcgaaaa tgccaagtat atttctcggt tgtttgccac acgacacaag      900

ttttacaaac aaaacaaaat ctgcactgaa cagtcaaatt ctccaccccc catcagacgc      960

cagcccacct ggagccgatc ctctctgccc aggcagcagc cgtacatcct gcctcccgtt     1020

cacgtccagt gtggtgagca ctactcggaa acgcacacct cgcaagacag catttttcat     1080

gggaatgaag aagccttgta ttgcaactct cacaacagcc tggacttaaa ttatttaaat     1140

ggcactgtca ccaatggcag cgtgtgtagc gttcacagcg tcaactccct caactgctcg     1200

caaagtttca tccaggcctc ccctgtatcc tccaacctca gtatccctgg gagtgacatc     1260

atgcgggccg actacatccc gagccaccgg cacagcgcga tcatcgtgcc ctcgtacagg     1320

ccaacccccg attatgagac agtcatgcgc cagatgaaga gggggatcct gcatacagac     1380

agccagagcc agtctctgag aaacctcaac attatcaaca cccatgccta caaccagcca     1440

gaggatctgg tgtacagcca accggagatg cgggagaggc acccctacac tgtcccttat     1500

gggccacagg gggtctacag caacaaactt gtcagtccat ctgaccagag gaacccaaag     1560

aataatgtgg taccaagcaa gccgggggca agcgccatct cgcacacggt gagcacccca     1620

gagctggcca acatgcagct gcagggcagc cataactaca gcacggccca catgcttaag     1680

aactatctct tcaggccacc gcccccctac ccacggccac gacctgccac cagcacccca     1740

gacctggcca gccaccgcca caagtacgtc agcggcagca gcccggacct ggtgacccgg     1800

aaggtgcagc tctcggtgaa gaccttccaa gaggacagct ctccggtggt tcatcagtct     1860

ctccaggagg tgagcgagcc cctcacggcc accaagcacc acggcactgt gaacaagcgc     1920

cacagcctgg aggtgatgaa cagcatggtg cggggcatgg aggccatgac gctcaagtcg     1980

ctccacctcc ccatggctcg ccgcaacacg ctccgggagc agggaccgcc cgaggagggg     2040

tcaggcagcc acgaggtccc ccagctccct cagtatcacc acaagaagac cttctctgat     2100

gccactatgc taatccacag cagcgagagt gaggaggagg aggaggaggc tccagaatcg     2160

gtgccccaga tccccatgct ccgggagaag atggagtaca gtgcccagct gcaggcggcc     2220

ctggcccgca tccccaacaa gcccccgcct gagtaccccg gtccaaggaa gagtgtgagc     2280

aatggggctc tgaggcagga ccaagccagc cttcctcccg ccatggccag agccagggtg     2340

ctgaggcatg ggccagccaa ggccatcagc atgtctcgga ctgacccgcc ggctgtcaac     2400

ggggcctctc tcggcccatc catctcggaa cccgacctga ctagtgtgaa ggagcgggtc     2460

aaaaaagagc ctgtgaagga gagacctgtg tctgaaatgt tttccctgga agacagcatt     2520

atagagagag agatgatgat caggaatcta gagaagcaga agatggcagg cctggaggca     2580

cagaagaggc cgctgatgtt ggcagcattg aatgggctct cggtggctcg agtctcaggg     2640

cgggaagaga atcgagttga tgccacccgg gttcccatgg acgagaggtt cagaaccctg     2700

aagaagaaac tagaagaggg aatggtgttc acagaatatg agcaaattcc aaagaaaaag     2760

gcgaatggca ttttcagcac agcagctctg ccagaaaacg ccgagcgcag ccgaatccgt     2820

gaagttgtcc cctatgagga gaatcgagta gagctgatac caaccaaaga aaataacaca     2880

ggatacatta atgcctccca catcaaggtg gtggttggcg gggcagaatg gcactacata     2940

gccacccagg ggcccctgcc acacacgtgc cacgacttct ggcagatggt gtgggagcag     3000

ggagtgaatg tgattgccat ggtcactgca gaggaggagg gtggacgaac caaaagccac     3060

cgatactggc ccaaactagg ttcaaagcac agctcagcca cctatggcaa gttcaaggtc     3120

accacgaagt ttcgaacgga ttctgtttgc tatgcaacca cgggcttgaa ggtcaagcac     3180

cttttgtctg ggcaagaaag gacggtgtgg catttacaat atactgactg gccagatcac     3240

ggctgtccag aagatgtcca aggattttta tcctacttgg aggagatcca gtcggtccgt     3300

cgccatacca acagcatgct ggaaggcacc aagaaccggc acccgcccat cgtggtccac     3360

tgtagtgctg gggtgggaag gaccggcgtg ctcattcttt ctgagctgat gatctactgc     3420

ttggaacata acgaaaaggt ggaagtgccc atgatgctga ggctcctcag ggagcagagg     3480

atgttcatga tccagactat cgctcagtac aagtttgtct accaagtcct catccagttc     3540

ctccaaaact ccagactcat ttaa                                            3564


<210>  506
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Pro Phe Gly Leu Lys Leu Arg Arg Thr Arg Arg Tyr Asn Val Leu 
1               5                   10                  15      


Ser Lys Asn Cys Phe Val Thr Arg Ile Arg Leu Leu Asp Ser Asn Val 
            20                  25                  30          


Ile Glu Cys Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Cys Leu Glu 
        35                  40                  45              


Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Thr His Tyr Phe Gly Leu 
    50                  55                  60                  


Trp Phe Leu Ser Lys Ser Gln Gln Ala Arg Trp Val Glu Leu Glu Lys 
65                  70                  75                  80  


Pro Leu Lys Lys His Leu Asp Lys Phe Ala Asn Glu Pro Leu Leu Phe 
                85                  90                  95      


Phe Gly Val Met Phe Tyr Val Pro Asn Val Ser Trp Leu Gln Gln Glu 
            100                 105                 110         


Ala Thr Arg Tyr Gln Tyr Tyr Leu Gln Val Lys Lys Asp Val Leu Glu 
        115                 120                 125             


Gly Arg Leu Arg Cys Thr Leu Asp Gln Val Ile Arg Leu Ala Gly Leu 
    130                 135                 140                 


Ala Val Gln Ala Asp Phe Gly Asp Tyr Asn Gln Phe Asp Ser Gln Asp 
145                 150                 155                 160 


Phe Leu Arg Glu Tyr Val Leu Phe Pro Met Asp Leu Ala Leu Glu Glu 
                165                 170                 175     


Ala Val Leu Glu Glu Leu Thr Gln Lys Val Ala Gln Glu His Lys Ala 
            180                 185                 190         


His Ser Gly Ile Leu Pro Ala Glu Ala Glu Leu Met Tyr Ile Asn Glu 
        195                 200                 205             


Val Glu Arg Leu Asp Gly Phe Gly Gln Glu Ile Phe Pro Val Lys Asp 
    210                 215                 220                 


Asn His Gly Asn Cys Val His Leu Gly Ile Phe Phe Met Gly Ile Phe 
225                 230                 235                 240 


Val Arg Asn Arg Ile Gly Arg Gln Ala Val Ile Tyr Arg Trp Asn Asp 
                245                 250                 255     


Met Gly Asn Ile Thr His Asn Lys Ser Thr Ile Leu Val Glu Leu Ile 
            260                 265                 270         


Asn Lys Glu Glu Thr Ala Leu Phe His Thr Asp Asp Ile Glu Asn Ala 
        275                 280                 285             


Lys Tyr Ile Ser Arg Leu Phe Ala Thr Arg His Lys Phe Tyr Lys Gln 
    290                 295                 300                 


Asn Lys Ile Cys Thr Glu Gln Ser Asn Ser Pro Pro Pro Ile Arg Arg 
305                 310                 315                 320 


Gln Pro Thr Trp Ser Arg Ser Ser Leu Pro Arg Gln Gln Pro Tyr Ile 
                325                 330                 335     


Leu Pro Pro Val His Val Gln Cys Gly Glu His Tyr Ser Glu Thr His 
            340                 345                 350         


Thr Ser Gln Asp Ser Ile Phe His Gly Asn Glu Glu Ala Leu Tyr Cys 
        355                 360                 365             


Asn Ser His Asn Ser Leu Asp Leu Asn Tyr Leu Asn Gly Thr Val Thr 
    370                 375                 380                 


Asn Gly Ser Val Cys Ser Val His Ser Val Asn Ser Leu Asn Cys Ser 
385                 390                 395                 400 


Gln Ser Phe Ile Gln Ala Ser Pro Val Ser Ser Asn Leu Ser Ile Pro 
                405                 410                 415     


Gly Ser Asp Ile Met Arg Ala Asp Tyr Ile Pro Ser His Arg His Ser 
            420                 425                 430         


Ala Ile Ile Val Pro Ser Tyr Arg Pro Thr Pro Asp Tyr Glu Thr Val 
        435                 440                 445             


Met Arg Gln Met Lys Arg Gly Ile Leu His Thr Asp Ser Gln Ser Gln 
    450                 455                 460                 


Ser Leu Arg Asn Leu Asn Ile Ile Asn Thr His Ala Tyr Asn Gln Pro 
465                 470                 475                 480 


Glu Asp Leu Val Tyr Ser Gln Pro Glu Met Arg Glu Arg His Pro Tyr 
                485                 490                 495     


Thr Val Pro Tyr Gly Pro Gln Gly Val Tyr Ser Asn Lys Leu Val Ser 
            500                 505                 510         


Pro Ser Asp Gln Arg Asn Pro Lys Asn Asn Val Val Pro Ser Lys Pro 
        515                 520                 525             


Gly Ala Ser Ala Ile Ser His Thr Val Ser Thr Pro Glu Leu Ala Asn 
    530                 535                 540                 


Met Gln Leu Gln Gly Ser His Asn Tyr Ser Thr Ala His Met Leu Lys 
545                 550                 555                 560 


Asn Tyr Leu Phe Arg Pro Pro Pro Pro Tyr Pro Arg Pro Arg Pro Ala 
                565                 570                 575     


Thr Ser Thr Pro Asp Leu Ala Ser His Arg His Lys Tyr Val Ser Gly 
            580                 585                 590         


Ser Ser Pro Asp Leu Val Thr Arg Lys Val Gln Leu Ser Val Lys Thr 
        595                 600                 605             


Phe Gln Glu Asp Ser Ser Pro Val Val His Gln Ser Leu Gln Glu Val 
    610                 615                 620                 


Ser Glu Pro Leu Thr Ala Thr Lys His His Gly Thr Val Asn Lys Arg 
625                 630                 635                 640 


His Ser Leu Glu Val Met Asn Ser Met Val Arg Gly Met Glu Ala Met 
                645                 650                 655     


Thr Leu Lys Ser Leu His Leu Pro Met Ala Arg Arg Asn Thr Leu Arg 
            660                 665                 670         


Glu Gln Gly Pro Pro Glu Glu Gly Ser Gly Ser His Glu Val Pro Gln 
        675                 680                 685             


Leu Pro Gln Tyr His His Lys Lys Thr Phe Ser Asp Ala Thr Met Leu 
    690                 695                 700                 


Ile His Ser Ser Glu Ser Glu Glu Glu Glu Glu Glu Ala Pro Glu Ser 
705                 710                 715                 720 


Val Pro Gln Ile Pro Met Leu Arg Glu Lys Met Glu Tyr Ser Ala Gln 
                725                 730                 735     


Leu Gln Ala Ala Leu Ala Arg Ile Pro Asn Lys Pro Pro Pro Glu Tyr 
            740                 745                 750         


Pro Gly Pro Arg Lys Ser Val Ser Asn Gly Ala Leu Arg Gln Asp Gln 
        755                 760                 765             


Ala Ser Leu Pro Pro Ala Met Ala Arg Ala Arg Val Leu Arg His Gly 
    770                 775                 780                 


Pro Ala Lys Ala Ile Ser Met Ser Arg Thr Asp Pro Pro Ala Val Asn 
785                 790                 795                 800 


Gly Ala Ser Leu Gly Pro Ser Ile Ser Glu Pro Asp Leu Thr Ser Val 
                805                 810                 815     


Lys Glu Arg Val Lys Lys Glu Pro Val Lys Glu Arg Pro Val Ser Glu 
            820                 825                 830         


Met Phe Ser Leu Glu Asp Ser Ile Ile Glu Arg Glu Met Met Ile Arg 
        835                 840                 845             


Asn Leu Glu Lys Gln Lys Met Ala Gly Leu Glu Ala Gln Lys Arg Pro 
    850                 855                 860                 


Leu Met Leu Ala Ala Leu Asn Gly Leu Ser Val Ala Arg Val Ser Gly 
865                 870                 875                 880 


Arg Glu Glu Asn Arg Val Asp Ala Thr Arg Val Pro Met Asp Glu Arg 
                885                 890                 895     


Phe Arg Thr Leu Lys Lys Lys Leu Glu Glu Gly Met Val Phe Thr Glu 
            900                 905                 910         


Tyr Glu Gln Ile Pro Lys Lys Lys Ala Asn Gly Ile Phe Ser Thr Ala 
        915                 920                 925             


Ala Leu Pro Glu Asn Ala Glu Arg Ser Arg Ile Arg Glu Val Val Pro 
    930                 935                 940                 


Tyr Glu Glu Asn Arg Val Glu Leu Ile Pro Thr Lys Glu Asn Asn Thr 
945                 950                 955                 960 


Gly Tyr Ile Asn Ala Ser His Ile Lys Val Val Val Gly Gly Ala Glu 
                965                 970                 975     


Trp His Tyr Ile Ala Thr Gln Gly Pro Leu Pro His Thr Cys His Asp 
            980                 985                 990         


Phe Trp Gln Met Val Trp Glu Gln  Gly Val Asn Val Ile  Ala Met Val 
        995                 1000                 1005             


Thr Ala  Glu Glu Glu Gly Gly  Arg Thr Lys Ser His  Arg Tyr Trp 
    1010                 1015                 1020             


Pro Lys  Leu Gly Ser Lys His  Ser Ser Ala Thr Tyr  Gly Lys Phe 
    1025                 1030                 1035             


Lys Val  Thr Thr Lys Phe Arg  Thr Asp Ser Val Cys  Tyr Ala Thr 
    1040                 1045                 1050             


Thr Gly  Leu Lys Val Lys His  Leu Leu Ser Gly Gln  Glu Arg Thr 
    1055                 1060                 1065             


Val Trp  His Leu Gln Tyr Thr  Asp Trp Pro Asp His  Gly Cys Pro 
    1070                 1075                 1080             


Glu Asp  Val Gln Gly Phe Leu  Ser Tyr Leu Glu Glu  Ile Gln Ser 
    1085                 1090                 1095             


Val Arg  Arg His Thr Asn Ser  Met Leu Glu Gly Thr  Lys Asn Arg 
    1100                 1105                 1110             


His Pro  Pro Ile Val Val His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1115                 1120                 1125             


Gly Val  Leu Ile Leu Ser Glu  Leu Met Ile Tyr Cys  Leu Glu His 
    1130                 1135                 1140             


Asn Glu  Lys Val Glu Val Pro  Met Met Leu Arg Leu  Leu Arg Glu 
    1145                 1150                 1155             


Gln Arg  Met Phe Met Ile Gln  Thr Ile Ala Gln Tyr  Lys Phe Val 
    1160                 1165                 1170             


Tyr Gln  Val Leu Ile Gln Phe  Leu Gln Asn Ser Arg  Leu Ile 
    1175                 1180                 1185         


<210>  507
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  507
atgagtgccc tgggagctgt cattgccctc ctgctctggg gacagctttt tgcagtggac       60

tcaggcaatg atgtcacgga tatcgcagat gacggctgcc cgaagccccc cgagattgca      120

catggctatg tggagcactc ggttcgctac cagtgtaaga actactacaa actgcgcaca      180

gaaggagatg gagtatacac cttaaataat aagaagcagt ggataaataa ggctgttgga      240

gataaacttc ctgaatgtga agcagatgac ggctgcccga agccccccga gattgcacat      300

ggctatgtgg agcactcggt ccgctaccag tgtaagaact actacaaact gcgcacagaa      360

ggagatggag tgtacacctt aaacaatgag aagcagtgga taaataaggc tgttggagat      420

aaacttcctg aatgtgaagc agtatgtggg aagcccaaga atccggcaaa cccagtgcag      480

cggatcctag gtggacacct tgatgccaaa ggcagctttc cctggcaggc taagatggtt      540

tcccaccata atctcaccac aggtgccacg ctgatcaatg aacaatggct gctgaccacg      600

gctaaaaatc tcttcctgaa ccattcagaa aatgcaacag cgaaagacat tgcccctact      660

ttaacactct atgtggggaa aaagcagctt gtagagattg agaaggttgt tctacaccct      720

aactactccc aggtagatat tgggctcatc aaactcaaac agaaggtgtc tgttaatgag      780

agagtgatgc ccatctgcct accttcaaag gattatgcag aagtagggcg tgtgggttat      840

gtttctggct gggggcgaaa tgccaatttt aaatttactg accatctgaa gtatgtcatg      900

ctgcctgtgg ctgaccaaga ccaatgcata aggcattatg aaggcagcac agtccccgaa      960

aagaagacac cgaagagccc tgtaggggtg cagcccatac tgaatgaaca caccttctgt     1020

gctggcatgt ctaagtacca agaagacacc tgctatggcg atgcgggcag tgcctttgcc     1080

gttcacgacc tggaggagga cacctggtat gcgactggga tcttaagctt tgataagagc     1140

tgtgctgtgg ctgagtatgg tgtgtatgtg aaggtgactt ccatccagga ctgggttcag     1200

aagaccatag ctgagaacta a                                               1221


<210>  508
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  509
<211>  1563
<212>  DNA
<213>  Homo sapiens

<400>  509
atggcggcgg cggcggcggc ggctggtgct gcagggtcgg cagctcccgc ggcagcggcc       60

ggcgccccgg gatctggggg cgcaccctca gggtcgcagg gggtgctgat cggggacagg      120

ctgtactccg gggtgctcat caccttggag aactgcctcc tgcctgacga caagctccgt      180

ttcacgccgt ccatgtcgag cggcctcgac accgacacag agaccgacct ccgcgtggtg      240

ggctgcgagc tcatccaggc ggccggtatc ctgctccgcc tgccgcaggt ggccatggct      300

accgggcagg tgttgttcca gcggttcttt tataccaagt ccttcgtgaa gcactccatg      360

gagcatgtgt caatggcctg tgtccacctg gcttccaaga tagaagaggc cccaagacgc      420

atacgggacg tcatcaatgt gtttcaccgc cttcgacagc tgagagacaa aaagaagccc      480

gtgcctctac tactggatca agattatgtt aatttaaaga accaaattat aaaggcggaa      540

agacgagttc tcaaagagtt gggtttctgc gtccatgtga agcatcctca taagataatc      600

gttatgtacc ttcaggtgtt agagtgtgag cgtaaccaac acctggtcca gacctcatgg      660

aattacatga acgacagcct tcgcaccgac gtcttcgtgc ggttccagcc agagagcatc      720

gcctgtgcct gcatttatct tgctgcccgg acgctggaga tccctttgcc caatcgtccc      780

cattggtttc ttttgtttgg agcaactgaa gaagaaattc aggaaatctg cttaaagatc      840

ttgcagcttt atgctcggaa aaaggttgat ctcacacacc tggagggtga agtggaaaaa      900

agaaagcacg ctatcgaaga ggcaaaggcc caagcccggg gcctgttgcc tgggggcaca      960

caggtgctgg atggtacctc ggggttctct cctgccccca agctggtgga atcccccaaa     1020

gaaggtaaag ggagcaagcc ttccccactg tctgtgaaga acaccaagag gaggctggag     1080

ggcgccaaga aagccaaggc ggacagcccc gtgaacggct tgccaaaggg gcgagagagt     1140

cggagtcgga gccggagccg tgagcagagc tactcgaggt ccccatcccg atcagcgtct     1200

cctaagagga ggaaaagtga cagcggctcc acatctggtg ggtccaagtc gcagagccgc     1260

tcccggagca ggagtgactc cccaccgaga caggcccccc gcagcgctcc ctacaaaggc     1320

tctgagattc ggggctcccg gaagtccaag gactgcaagt acccccagaa gccacacaag     1380

tctcggagcc ggagttcttc ccgttctcga agcaggtcac gggagcgggc ggataatccg     1440

ggaaaataca agaagaaaag tcattactac agagatcagc gacgagagcg ctcgaggtcg     1500

tatgaacgca caggccgtcg ctatgagcgg gaccaccctg ggcacagcag gcatcggagg     1560

tga                                                                   1563


<210>  510
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Asn Tyr Met Asn 
    210                 215                 220                 


Asp Ser Leu Arg Thr Asp Val Phe Val Arg Phe Gln Pro Glu Ser Ile 
225                 230                 235                 240 


Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Thr Leu Glu Ile Pro Leu 
                245                 250                 255     


Pro Asn Arg Pro His Trp Phe Leu Leu Phe Gly Ala Thr Glu Glu Glu 
            260                 265                 270         


Ile Gln Glu Ile Cys Leu Lys Ile Leu Gln Leu Tyr Ala Arg Lys Lys 
        275                 280                 285             


Val Asp Leu Thr His Leu Glu Gly Glu Val Glu Lys Arg Lys His Ala 
    290                 295                 300                 


Ile Glu Glu Ala Lys Ala Gln Ala Arg Gly Leu Leu Pro Gly Gly Thr 
305                 310                 315                 320 


Gln Val Leu Asp Gly Thr Ser Gly Phe Ser Pro Ala Pro Lys Leu Val 
                325                 330                 335     


Glu Ser Pro Lys Glu Gly Lys Gly Ser Lys Pro Ser Pro Leu Ser Val 
            340                 345                 350         


Lys Asn Thr Lys Arg Arg Leu Glu Gly Ala Lys Lys Ala Lys Ala Asp 
        355                 360                 365             


Ser Pro Val Asn Gly Leu Pro Lys Gly Arg Glu Ser Arg Ser Arg Ser 
    370                 375                 380                 


Arg Ser Arg Glu Gln Ser Tyr Ser Arg Ser Pro Ser Arg Ser Ala Ser 
385                 390                 395                 400 


Pro Lys Arg Arg Lys Ser Asp Ser Gly Ser Thr Ser Gly Gly Ser Lys 
                405                 410                 415     


Ser Gln Ser Arg Ser Arg Ser Arg Ser Asp Ser Pro Pro Arg Gln Ala 
            420                 425                 430         


Pro Arg Ser Ala Pro Tyr Lys Gly Ser Glu Ile Arg Gly Ser Arg Lys 
        435                 440                 445             


Ser Lys Asp Cys Lys Tyr Pro Gln Lys Pro His Lys Ser Arg Ser Arg 
    450                 455                 460                 


Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Glu Arg Ala Asp Asn Pro 
465                 470                 475                 480 


Gly Lys Tyr Lys Lys Lys Ser His Tyr Tyr Arg Asp Gln Arg Arg Glu 
                485                 490                 495     


Arg Ser Arg Ser Tyr Glu Arg Thr Gly Arg Arg Tyr Glu Arg Asp His 
            500                 505                 510         


Pro Gly His Ser Arg His Arg Arg 
        515                 520 


<210>  511
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  511
atggagagct cccgcgtgag gctgctgccc ctcctgggcg ccgccctgct gctgatgcta       60

cctctgttgg gtacccgtgc ccaggaggac gccgagctcc agccccgagc cctggacatc      120

tactctgccg tggatgatgc ctcccacgag aaggagctga tcgaagcgct gcaagaagtc      180

ttgaagaagc tcaagagtaa acgtgttccc atctatgaga agaagtatgg ccaagtcccc      240

atgtgtgacg ccggtgagca gtgtgcagtg aggaaagggg caaggatcgg gaagctgtgt      300

gactgtcccc gaggaacctc ctgcaattcc ttcctcctga agtgcttatg a               351


<210>  512
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210>  513
<211>  11736
<212>  DNA
<213>  Homo sapiens

<400>  513
atggaggacg aggagagaca gaagaagctg gaggccggca aagccaagat tgaagaactc       60

tctttagctt ttcttgtcag acagcttgcc cagtttcgac aaagaaaagc tcagtcggat      120

gggcagagtc cttccaagaa gcagaaaaaa aagagaaaaa cgtcaagcag taaacatgat      180

gtgtcagcac accatgattt gaatattgat caatcacagt gtaatgaaat gtacataaat      240

agttctcaga gagtagaatc aactgtgatt cctgaatcta caataatgag aactctacat      300

agtggagaaa taaccagtca tgagcagggc ttctctgtgg aactggaaag tgaaatttca      360

accacagcag atgactgcag ttcagaggta aatggttgca gttttgtgat gagaacagga      420

aagcctacaa atttattaag ggaagaagaa tttggtgttg atgattctta ttctgaacaa      480

ggagcacaag acagtccgac tcatctagag atgatggaaa gtgagttggc tgggaagcag      540

catgagattg aagagctaaa cagagagctg gaagaaatga gggttaccta tgggactgaa      600

ggactgcagc agttacaaga atttgaagct gccattaaac aaagagatgg cattataacc      660

cagctcactg ctaatttaca acaagcaaga agagaaaagg atgagacaat gagagaattt      720

ttagagttga cagaacagag tcaaaaatta cagattcaat ttcagcaatt acaggctagt      780

gaaactctga gaaacagcac tcatagtagc acagctgcag acttactaca agccaaacaa      840

cagatcctca ctcatcaaca gcagcttgaa gaacaagacc acttattaga agattatcag      900

aaaaagaaag aagacttcac aatgcaaatt agtttcttgc aagagaaaat taaagtatat      960

gaaatggaac aagataaaaa agtagaaaac tcaaataaag aagaaataca ggaaaaggag     1020

acaatcattg aagaattaaa cacaaaaata atagaagaag aaaagaaaac tcttgagcta     1080

aaggataaat taacaactgc tgataaatta ctaggagaat tacaagaaca gattgtgcaa     1140

aagaaccaag aaataaaaaa catgaaatta gagctgacta attctaagca aaaagaaaga     1200

cagtcttctg aagaaataaa acagttaatg gggacagtcg aagaacttca gaagagaaat     1260

cataaagaca gccagttcga aactgatata gtacaacgaa tggaacaaga aacacaaaga     1320

aagttagaac aactccgggc agagctggat gagatgtatg ggcagcagat agtgcaaatg     1380

aaacaagaat taataagaca acacatggca cagatggagg aaatgaaaac acggcataag     1440

ggagaaatgg agaatgcttt aaggtcatat tcaaatatta cagttaatga agatcagata     1500

aagttaatga atgtggcaat aaatgaactg aatataaaat tgcaagatac taactctcaa     1560

aaggaaaaac tcaaggaaga actaggacta attttagaag aaaagtgtgc tctacagaga     1620

cagcttgaag accttgttga agaattgagc ttttcaaggg aacagattca gagagctaga     1680

cagacaatag ctgaacaaga aagtaaactt aatgaagcac ataagtccct tagtacagtg     1740

gaagatttga aagctgagat tgtttctgca tctgaatcca gaaaggaact agaattaaaa     1800

catgaagcag aagttacaaa ttacaagata aaacttgaaa tgttagaaaa agaaaagaat     1860

gctgtgttag acagaatggc tgaatcacaa gaagctgaat tagagaggct gagaacacag     1920

cttctattta gtcacgaaga agagctttcc aaactgaagg aagatttaga aattgaacat     1980

cgaataaata ttgaaaaact taaagataat ttaggcattc actataaaca gcagatagat     2040

ggtttacaga atgaaatgag tcaaaagata gaaaccatgc agtttgaaaa ggacaatttg     2100

ataactaagc agaatcaatt aattttggaa atttcaaagc taaaagattt acagcagtct     2160

cttgtaaatt caaagtcaga agaaatgact cttcaaatca atgaacttca aaaagaaatt     2220

gaaatactca gacaagaaga aaaagaaaag ggtacacttg aacaagaagt tcaagaatta     2280

caacttaaaa cagaattgtt agaaaaacag atgaaggaaa aagagaatga tcttcaagaa     2340

aaatttgcac aacttgaagc agagaatagc attcttaaag atgaaaagaa aacccttgaa     2400

gacatgttga aaatacatac tcctgttagc caagaagaaa gattgatttt cttagactcc     2460

attaagtcca aatccaaaga ctctgtgtgg gaaaaagaaa tagaaatact tatagaggaa     2520

aatgaggacc tcaaacaaca atgtattcag ctaaatgaag agattgaaaa gcaaaggaac     2580

actttttcat ttgctgaaaa aaactttgaa gttaactatc aagagttaca agaggagtat     2640

gcttgccttc tcaaagtaaa agatgattta gaagacagta aaaataaaca ggaattagag     2700

tataaaagta aacttaaagc acttaatgaa gagcttcatt tgcaaagaat aaatccaact     2760

acagtgaaaa tgaaaagttc tgtctttgat gaagacaaaa cttttgtagc agaaacattg     2820

gaaatgggtg aggttgttga aaaggataca acagaactca tggaaaaact tgaggtaacc     2880

aagcgagaga aattagagct gtcacagaga ctgtctgatc tttctgaaca attgaaacag     2940

aaacatggtg agattagttt tctaaatgaa gaagttaaat ctttaaagca agagaaagaa     3000

caagtttcat tgagatgtag agagctagaa atcattatta accacaacag ggcagaaaat     3060

gtacagtcat gtgatactca agtaagctct ttattagatg gagttgtgac catgacaagc     3120

aggggtgctg aaggatcagt ttctaaagta aataaaagtt ttggtgaaga atcaaaaata     3180

atggtggaag ataaagtttc ttttgaaaat atgactgttg gagaagaaag taagcaagaa     3240

cagttgattt tggatcactt accatctgta acaaaggaat catcacttag agcaactcaa     3300

ccaagtgaaa atgataaact tcagaaagaa ctcaatgtac ttaaatcaga acagaatgat     3360

ttaaggctac agatggaagc ccaacgcatt tgcctctctc tggtttattc aactcatgtg     3420

gatcaggttc gtgaatatat ggaaaatgaa aaagataaag ctctttgcag tcttaaagaa     3480

gagcttattt ttgctcaaga ggaaaagatc aaggaacttc agaaaataca ccagttagaa     3540

ctacagacta tgaaaacaca agaaacaggt gatgaaggaa agcctttaca tctgctcatt     3600

ggaaaacttc aaaaggcagt gtctgaagaa tgttcttatt ttttacagac tttatgcagt     3660

gtccttggtg aatattatac tcctgcttta aaatgtgaag taaatgcaga agacaaagag     3720

aattctggtg attacatttc tgaaaatgaa gatccagaat tacaagatta tagatatgaa     3780

gttcaagact ttcaagaaaa tatgcacact cttctcaaca aagtaacaga agaatacaac     3840

aaactcttgg tacttcaaac acgactaagc aagatctggg gacagcagac agatggtatg     3900

aaacttgaat ttggagaaga aaaccttcca aaagaggaaa cagagttttt atcaatccat     3960

tctcagatga ccaatttgga agacattgat gtcaatcata aaagcaagtt atcttctctg     4020

caagatcttg aaaaaactaa acttgaagaa caagttcaag aattagaaag cctcatatcc     4080

tctttgcagc aacagttgaa agaaactgaa caaaactatg aggcagagat ccactgttta     4140

cagaagaggc ttcaagctgt tagtgagtcc acggttccgc caagcttacc tgttgattcg     4200

gtggtaatta cagaatctga tgcacagaga acaatgtacc ctggaagttg tgtgaaaaag     4260

aatattgatg gtacaataga gttttctggt gaatttggag tgaaagagga aacaaatatc     4320

gttaagttgc ttgaaaaaca ataccaagaa caattagaag aagaagtagc taaggttatt     4380

gtgtcaatga gtatagcatt tgctcaacaa actgaactgt ctagaatatc tgggggaaaa     4440

gaaaatactg catcatcaaa gcaagcacat gctgtgtgtc agcaagaaca acattatttt     4500

aatgaaatga aattatcaca ggatcaaatt ggttttcaga cttttgagac agtggatgtg     4560

aaatttaaag aagaatttaa accacttagt aaagagttag gagaacatgg aaaggaaatt     4620

ttattatcaa atagtgatcc ccatgatata ccagaatcaa aggactgtgt gctgactatt     4680

tcagaagaaa tgttctccaa agataaaaca tttatagtta gacagtctat tcatgatgag     4740

atttcagtgt caagcatgga tgcttctaga caactaatgt tgaatgaaga acagttggaa     4800

gatatgagac aggaacttgt acgacaatac caagaacatc aacaggcaac ggaattgtta     4860

aggcaagcac atatgcggca aatggagaga cagcgagaag accaggaaca gctacaagaa     4920

gagattaaga gacttaatag acaattagcc cagagatcct ccatagataa tgaaaacctg     4980

gtttcagaga gagagagggt gcttttagag gagctggaag cactaaagca gctgtcttta     5040

gctggaagag agaagctgtg ttgtgagctg cgcaacagca gtacgcaaac acagaatgga     5100

aatgaaaacc aaggagaagt tgaagaacaa acatttaaag aaaaggaatt agacagaaaa     5160

cctgaagatg tgcctcctga gattttgtct aatgaaaggt atgcactcca gaaagctaat     5220

aatagacttt tgaagatcct cttagaagtt gtaaagacaa cagcagctgt tgaagaaaca     5280

attggtcgcc atgtccttgg gattctagat agatctagta aaagccagtc atctgccagc     5340

ctaatttgga ggtcagaagc agaggcatct gtaaagtcat gtgtccatga ggaacataca     5400

agagttacag atgaatccat tccctcttat tctggaagtg atatgccaag aaatgacatt     5460

aacatgtggt caaaagtaac tgaggaagga acagagctgt cacaacgact tgtgaggagt     5520

ggttttgctg gaactgaaat agaccctgaa aatgaagaac ttatgctgaa cattagctct     5580

cgactacaag cagcagttga aaaactccta gaagccataa gtgaaactag cagtcagctt     5640

gaacatgcga aagtgacaca gacagagttg atgcgtgagt catttagaca gaaacaagaa     5700

gcaacagagt cccttaagtg ccaagaggaa cttcgagagc gccttcatga ggagtccagg     5760

gccagagaac agctagctgt ggagctcagt aaggctgagg gcgtcattga tggctatgca     5820

gatgaaaaaa ctctttttga aaggcaaatt caggaaaaaa ctgatataat agatcgtctt     5880

gagcaggagt tgttatgtgc aagtaacagg ttgcaagaat tggaggcaga gcaacagcag     5940

atccaagaag aaagagaatt actgtccaga caaaaggaag ctatgaaagc agaggcaggc     6000

ccagttgaac aacaattact acaggagaca gaaaaattaa tgaaggaaaa actagaagta     6060

caatgtcaag ctgaaaaagt acgtgatgac cttcaaaaac aagtgaaagc tctagaaata     6120

gatgtggaag aacaagtcag taggtttata gagctggaac aagaaaaaaa tactgaacta     6180

atggatttaa gacagcaaaa ccaagcattg gaaaagcagt tagaaaaaat gagaaaattt     6240

ttagatgagc aagccattga cagagaacat gagagagatg tattccaaca ggaaatacag     6300

aaactagaac agcaacttaa ggttgttcct cgattccagc ctatcagtga acatcaaact     6360

agagaggttg aacagttagc aaatcatctg aaagaaaaaa cagacaaatg cagtgagctt     6420

ttgctctcta aagagcagct tcaaagggat atacaagaaa ggaatgaaga aatagagaaa     6480

ctggagttca gagtaagaga actggagcag gcgcttcttg tgagtgcaga tacttttcaa     6540

aaggtagagg accgaaaaca ctttggagct gtagaagcta aaccagaatt gtccctagaa     6600

gtacaattgc aggctgaacg agatgccata gacagaaagg aaaaagagat tacaaactta     6660

gaagagcaat tagaacagtt tagagaagaa ctggaaaata agaatgaaga agttcaacaa     6720

ttacatatgc aattagaaat acagaaaaag gaatctacta cccgcctaca agaacttgaa     6780

caggaaaaca aattatttaa ggatgacatg gagaaactgg gacttgccat aaaggaatct     6840

gatgccatgt ctactcaaga ccaacatgtg ctatttggga aatttgctca aataatacag     6900

gaaaaagagg tagaaattga ccaattaaat gaacaagtta cgaaactcca gcagcaactt     6960

aaaattacaa cagataacaa ggttattgaa gaaaaaaatg aactgataag ggatcttgaa     7020

acccaaatag aatgtttgat gagtgatcaa gaatgtgtga agagaaatag agaagaagaa     7080

atagagcagc tcaatgaagt gattgaaaaa cttcaacagg aattggcaaa tattggacag     7140

aagacatcaa tgaatgctca ttccctctca gaagaagcag acagtttaaa acatcaattg     7200

gatgtggtta tagctgaaaa gctggccttg gaacagcaag tagaaaccgc taatgaagaa     7260

atgaccttca tgaaaaatgt acttaaagaa accaatttta aaatgaatca gctaacacag     7320

gaattattca gcttaaagag agaacgtgaa agtgtggaaa agattcaaag cataccagag     7380

aatagtgtta acgtggctat agatcatctg agcaaagaca aacctgaact agaagtagtc     7440

cttacagagg atgctcttaa atccctagaa aatcagacat acttcaaatc ttttgaagaa     7500

aatggcaaag gttccataat taatttggaa acaaggttgc tacaacttga gagcactgtt     7560

agtgcaaagg acttagaact tacccagtgt tataaacaaa taaaagacat gcaagaacaa     7620

ggccagtttg aaacagaaat gcttcaaaag aagattgtaa acctacagaa aatagttgaa     7680

gaaaaagtgg ctgctgctct tgtcagtcaa atccaacttg aggcagttca ggaatatgca     7740

aaattctgtc aagataatca aacaatttca tcagaacctg aaagaacaaa tattcagaat     7800

ttaaatcaac taagagaaga tgagttgggg tcagatatat cagcattaac cttgagaata     7860

tcagaattag aaagccaggt tgttgaaatg catactagtt tgattttaga aaaagaacaa     7920

gtagaaattg cagaaaaaaa tgttttagaa aaagaaaaga agctgctaga actacagaag     7980

ctattggagg gcaatgagaa aaaacagaga gagaaagaaa agaaaagaag ccctcaagat     8040

gttgaagttc tcaagacaac tactgagcta tttcatagca atgaagaaag tggatttttt     8100

aatgaactcg aggctcttag agctgaatca gtggctacca aagcagaact tgccagttat     8160

aaagaaaagg ctgaaaaact tcaagaagag cttttggtaa aagaaacaaa tatgacatct     8220

cttcagaaag acttaagcca agttagggat cacctcgcag aggcaaaaga gaaattgtcc     8280

attttagaaa aagaagatga gactgaggta caagaaagca aaaaggcctg catgtttgag     8340

ccacttccta taaaactgag taagagcatt gcatcccaga cagatgggac tctgaagatc     8400

agtagcagca atcagactcc acaaattctt gttaaaaatg caggaataca aattaattta     8460

cagagtgaat gttcctcaga agaagttact gaaataatca gtcagtttac tgaaaaaatt     8520

gagaagatgc aagaactaca tgctgctgaa attttggaca tggaatccag acatatttca     8580

gaaactgaaa ccttaaagag ggaacactat gttgccgttc agttactgaa agaggaatgt     8640

ggtaccttga aggcagtgat acagtgtctg agaagtaaag aggtatttgg tttttataat     8700

atgtgttttt caacattgtg tgattctgga tcagactggg gtcagggaat ttatcttaca     8760

cacagtcagg gatttgacat agcatcagaa ggccgaggag aagaaagtga aagtgcaaca     8820

gattcctttc caaagaaaat aaagggatta ctgagagctg tccataatga aggcatgcag     8880

gtgctttctc tcactgagtc tccctatagt gatggagagg accattctat tcagcaggtt     8940

tcagaacctt ggctagaaga gagaaaagct tacatcaata caatctcatc tctaaaggat     9000

ttaattacaa agatgcaact gcaaagagaa gccgaggttt atgatagttc tcaatctcat     9060

gagagcttct cagactggcg aggtgaacta ctgcttgccc ttcaacaagt tttcttagaa     9120

gagcgtagtg ttttactagc agcatttcgg acggagctga cagctctagg tactacagat     9180

gcagttggtt tactaaactg tttggaacag agaatacaag aacagggtgt tgaatatcaa     9240

gcagctatgg aatgcctcca gaaagcagat agaaggagtt tgttatctga aattcaggca     9300

ctgcatgcac aaatgaatgg taggaaaatt actctgaaaa gagaacaaga gagtgagaaa     9360

ccaagccaag aactcttgga atataatata cagcagaagc agtctcaaat gctggagatg     9420

caagtggagc tcagcagtat gaaagacaga gcaacggaac tgcaggagca gctgagttct     9480

gagaaaatgg tggttgctga actgaagagt gagcttgcac aaactaaatt ggaactagaa     9540

acaacactca aggcacagca taaacaccta aaagaattgg aggctttcag gttggaagtt     9600

aaagataaga cagatgaagt acatttgctt aatgacacat tagcaagtga acagaaaaaa     9660

tcaagagagc tccagtgggc tttggagaaa gagaaagcca agttgggacg cagtgaagaa     9720

cgggataaag aagaacttga ggatctgaag ttttcacttg agagtcagaa acaaaggaat     9780

cttcagctaa atctactttt ggaacaacag aaacaactac tgaacgaatc ccagcaaaaa     9840

atagaatcac agagaatgct atatgatgcc cagttgtcag aagaacaagg tcgaaactta     9900

gagcttcagg tacttcttga atctgagaaa gttcgaattc gggaaatgag tagtacccta     9960

gatagggagc gggaattgca cgcacagctg cagagcagtg atggtactgg acagtctcgg    10020

ccacccttgc cctcagagga cctactgaaa gagctgcaga aacagctaga ggaaaaacac    10080

agtcgcatag tagaattgtt aaatgagact gaaaaatata aactggattc tttgcaaaca    10140

cgacagcaaa tggaaaaaga taggcaggtt cacaggaaaa cactgcagac agaacaggag    10200

gccaacactg agggacagaa aaaaatgcat gagctccagt ccaaagtgga agatcttcag    10260

cgccagctgg aagagaaaag acaacaagtt tataagttag accttgaagg acagcgacta    10320

caaggaatca tgcaggaatt ccagaagcaa gaactagaac gagaagaaaa acgagaaagt    10380

agaagaattc tgtatcagaa ccttaatgag ccaaccacgt ggagcttaac cagtgataga    10440

actagaaatt gggttcttca acagaaaata gaaggagaaa caaaagaatc aaactacgct    10500

aaattgattg aaatgaatgg aggaggaacc ggctgtaatc atgaattaga aatgatcaga    10560

caaaagcttc aatgtgtagc ttcaaaacta caggttctac cccagaaagc ctctgagaga    10620

ctacagtttg aaacagcaga tgatgaagat ttcatttggg ttcaggaaaa tattgatgaa    10680

attattttac aactacagaa attaactggc cagcaaggtg aagagcccag cttggtgtcc    10740

ccaagtactt cttgtggctc attgactgaa agactactga gacaaaatgc tgagctgaca    10800

gggcatatca gtcaactgac tgaagagaag aatgacttaa ggaacatggt tatgaagctg    10860

gaagagcaga tcaggtggta tcgacagaca ggagctggta gagataattc ttccaggttt    10920

tcattgaatg gtggtgccaa cattgaagcc atcattgcct ctgaaaaaga agtatggaac    10980

agagaaaaat tgactctcca gaaatctttg aaaagggcag aggctgaagt atacaaactg    11040

aaagctgaac taagaaatga ctctttactt caaactctga gccctgattc tgaacatgtc    11100

actttaaaga gaatttatgg taaatacttg agggcagaaa gttttcgaaa ggctctcatt    11160

taccagaaga aatacctgct gctgttactg ggtgggttcc aggaatgtga agatgccacc    11220

ttggccctgc ttgcccggat gggggggcag ccagctttca cggatctaga ggtgatcacc    11280

aatcgcccaa agggcttcac caggtttcgg tcggccgtca gagtatccat tgcaatttcc    11340

agaatgaaat ttttggttcg acggtggcat cgagtcacag gttctgtttc catcaatatt    11400

aacagagatg gctttggact gaatcaaggt gcagaaaaga ctgactcatt ttatcattct    11460

tctggtgggc tggagttata tggagaacca agacatacta cgtatcgctc aagatcagat    11520

ctggactata ttaggtcccc tttaccattt cagaataggt acccaggcac tccagctgat    11580

ttcaatcctg gttctttagc atgttctcag cttcagaatt acgatcctga cagagcccta    11640

acagattata tcactcggct agaggcactg caaagacgac ttggaactat acagtcaggt    11700

tcaactactc aatttcatgc tggcatgaga agataa                              11736


<210>  514
<211>  3911
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe 
            20                  25                  30          


Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln 
        35                  40                  45              


Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His 
    50                  55                  60                  


His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn 
65                  70                  75                  80  


Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met 
                85                  90                  95      


Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser 
            100                 105                 110         


Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser 
        115                 120                 125             


Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn 
    130                 135                 140                 


Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln 
145                 150                 155                 160 


Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu 
                165                 170                 175     


Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu 
            180                 185                 190         


Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe 
        195                 200                 205             


Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala 
    210                 215                 220                 


Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe 
225                 230                 235                 240 


Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln 
                245                 250                 255     


Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala 
            260                 265                 270         


Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln 
        275                 280                 285             


Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu 
    290                 295                 300                 


Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr 
305                 310                 315                 320 


Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile 
                325                 330                 335     


Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu 
            340                 345                 350         


Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp 
        355                 360                 365             


Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu 
    370                 375                 380                 


Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg 
385                 390                 395                 400 


Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu 
                405                 410                 415     


Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln 
            420                 425                 430         


Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu 
        435                 440                 445             


Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu 
    450                 455                 460                 


Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys 
465                 470                 475                 480 


Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn 
                485                 490                 495     


Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile 
            500                 505                 510         


Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu 
        515                 520                 525             


Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp 
    530                 535                 540                 


Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg 
545                 550                 555                 560 


Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser 
                565                 570                 575     


Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu 
            580                 585                 590         


Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr 
        595                 600                 605             


Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp 
    610                 615                 620                 


Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln 
625                 630                 635                 640 


Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly 
            660                 665                 670         


Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln 
        675                 680                 685             


Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln 
    690                 695                 700                 


Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser 
705                 710                 715                 720 


Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu 
                725                 730                 735     


Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr 
            740                 745                 750         


Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu 
        755                 760                 765             


Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln 
    770                 775                 780                 


Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu 
785                 790                 795                 800 


Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile 
                805                 810                 815     


Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys 
            820                 825                 830         


Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys 
        835                 840                 845             


Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe 
    850                 855                 860                 


Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr 
865                 870                 875                 880 


Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys 
                885                 890                 895     


Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu 
            900                 905                 910         


His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val 
        915                 920                 925             


Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu 
    930                 935                 940                 


Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr 
945                 950                 955                 960 


Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu 
                965                 970                 975     


Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val 
            980                 985                 990         


Lys Ser Leu Lys Gln Glu Lys Glu  Gln Val Ser Leu Arg  Cys Arg Glu 
        995                 1000                 1005             


Leu Glu  Ile Ile Ile Asn His  Asn Arg Ala Glu Asn  Val Gln Ser 
    1010                 1015                 1020             


Cys Asp  Thr Gln Val Ser Ser  Leu Leu Asp Gly Val  Val Thr Met 
    1025                 1030                 1035             


Thr Ser  Arg Gly Ala Glu Gly  Ser Val Ser Lys Val  Asn Lys Ser 
    1040                 1045                 1050             


Phe Gly  Glu Glu Ser Lys Ile  Met Val Glu Asp Lys  Val Ser Phe 
    1055                 1060                 1065             


Glu Asn  Met Thr Val Gly Glu  Glu Ser Lys Gln Glu  Gln Leu Ile 
    1070                 1075                 1080             


Leu Asp  His Leu Pro Ser Val  Thr Lys Glu Ser Ser  Leu Arg Ala 
    1085                 1090                 1095             


Thr Gln  Pro Ser Glu Asn Asp  Lys Leu Gln Lys Glu  Leu Asn Val 
    1100                 1105                 1110             


Leu Lys  Ser Glu Gln Asn Asp  Leu Arg Leu Gln Met  Glu Ala Gln 
    1115                 1120                 1125             


Arg Ile  Cys Leu Ser Leu Val  Tyr Ser Thr His Val  Asp Gln Val 
    1130                 1135                 1140             


Arg Glu  Tyr Met Glu Asn Glu  Lys Asp Lys Ala Leu  Cys Ser Leu 
    1145                 1150                 1155             


Lys Glu  Glu Leu Ile Phe Ala  Gln Glu Glu Lys Ile  Lys Glu Leu 
    1160                 1165                 1170             


Gln Lys  Ile His Gln Leu Glu  Leu Gln Thr Met Lys  Thr Gln Glu 
    1175                 1180                 1185             


Thr Gly  Asp Glu Gly Lys Pro  Leu His Leu Leu Ile  Gly Lys Leu 
    1190                 1195                 1200             


Gln Lys  Ala Val Ser Glu Glu  Cys Ser Tyr Phe Leu  Gln Thr Leu 
    1205                 1210                 1215             


Cys Ser  Val Leu Gly Glu Tyr  Tyr Thr Pro Ala Leu  Lys Cys Glu 
    1220                 1225                 1230             


Val Asn  Ala Glu Asp Lys Glu  Asn Ser Gly Asp Tyr  Ile Ser Glu 
    1235                 1240                 1245             


Asn Glu  Asp Pro Glu Leu Gln  Asp Tyr Arg Tyr Glu  Val Gln Asp 
    1250                 1255                 1260             


Phe Gln  Glu Asn Met His Thr  Leu Leu Asn Lys Val  Thr Glu Glu 
    1265                 1270                 1275             


Tyr Asn  Lys Leu Leu Val Leu  Gln Thr Arg Leu Ser  Lys Ile Trp 
    1280                 1285                 1290             


Gly Gln  Gln Thr Asp Gly Met  Lys Leu Glu Phe Gly  Glu Glu Asn 
    1295                 1300                 1305             


Leu Pro  Lys Glu Glu Thr Glu  Phe Leu Ser Ile His  Ser Gln Met 
    1310                 1315                 1320             


Thr Asn  Leu Glu Asp Ile Asp  Val Asn His Lys Ser  Lys Leu Ser 
    1325                 1330                 1335             


Ser Leu  Gln Asp Leu Glu Lys  Thr Lys Leu Glu Glu  Gln Val Gln 
    1340                 1345                 1350             


Glu Leu  Glu Ser Leu Ile Ser  Ser Leu Gln Gln Gln  Leu Lys Glu 
    1355                 1360                 1365             


Thr Glu  Gln Asn Tyr Glu Ala  Glu Ile His Cys Leu  Gln Lys Arg 
    1370                 1375                 1380             


Leu Gln  Ala Val Ser Glu Ser  Thr Val Pro Pro Ser  Leu Pro Val 
    1385                 1390                 1395             


Asp Ser  Val Val Ile Thr Glu  Ser Asp Ala Gln Arg  Thr Met Tyr 
    1400                 1405                 1410             


Pro Gly  Ser Cys Val Lys Lys  Asn Ile Asp Gly Thr  Ile Glu Phe 
    1415                 1420                 1425             


Ser Gly  Glu Phe Gly Val Lys  Glu Glu Thr Asn Ile  Val Lys Leu 
    1430                 1435                 1440             


Leu Glu  Lys Gln Tyr Gln Glu  Gln Leu Glu Glu Glu  Val Ala Lys 
    1445                 1450                 1455             


Val Ile  Val Ser Met Ser Ile  Ala Phe Ala Gln Gln  Thr Glu Leu 
    1460                 1465                 1470             


Ser Arg  Ile Ser Gly Gly Lys  Glu Asn Thr Ala Ser  Ser Lys Gln 
    1475                 1480                 1485             


Ala His  Ala Val Cys Gln Gln  Glu Gln His Tyr Phe  Asn Glu Met 
    1490                 1495                 1500             


Lys Leu  Ser Gln Asp Gln Ile  Gly Phe Gln Thr Phe  Glu Thr Val 
    1505                 1510                 1515             


Asp Val  Lys Phe Lys Glu Glu  Phe Lys Pro Leu Ser  Lys Glu Leu 
    1520                 1525                 1530             


Gly Glu  His Gly Lys Glu Ile  Leu Leu Ser Asn Ser  Asp Pro His 
    1535                 1540                 1545             


Asp Ile  Pro Glu Ser Lys Asp  Cys Val Leu Thr Ile  Ser Glu Glu 
    1550                 1555                 1560             


Met Phe  Ser Lys Asp Lys Thr  Phe Ile Val Arg Gln  Ser Ile His 
    1565                 1570                 1575             


Asp Glu  Ile Ser Val Ser Ser  Met Asp Ala Ser Arg  Gln Leu Met 
    1580                 1585                 1590             


Leu Asn  Glu Glu Gln Leu Glu  Asp Met Arg Gln Glu  Leu Val Arg 
    1595                 1600                 1605             


Gln Tyr  Gln Glu His Gln Gln  Ala Thr Glu Leu Leu  Arg Gln Ala 
    1610                 1615                 1620             


His Met  Arg Gln Met Glu Arg  Gln Arg Glu Asp Gln  Glu Gln Leu 
    1625                 1630                 1635             


Gln Glu  Glu Ile Lys Arg Leu  Asn Arg Gln Leu Ala  Gln Arg Ser 
    1640                 1645                 1650             


Ser Ile  Asp Asn Glu Asn Leu  Val Ser Glu Arg Glu  Arg Val Leu 
    1655                 1660                 1665             


Leu Glu  Glu Leu Glu Ala Leu  Lys Gln Leu Ser Leu  Ala Gly Arg 
    1670                 1675                 1680             


Glu Lys  Leu Cys Cys Glu Leu  Arg Asn Ser Ser Thr  Gln Thr Gln 
    1685                 1690                 1695             


Asn Gly  Asn Glu Asn Gln Gly  Glu Val Glu Glu Gln  Thr Phe Lys 
    1700                 1705                 1710             


Glu Lys  Glu Leu Asp Arg Lys  Pro Glu Asp Val Pro  Pro Glu Ile 
    1715                 1720                 1725             


Leu Ser  Asn Glu Arg Tyr Ala  Leu Gln Lys Ala Asn  Asn Arg Leu 
    1730                 1735                 1740             


Leu Lys  Ile Leu Leu Glu Val  Val Lys Thr Thr Ala  Ala Val Glu 
    1745                 1750                 1755             


Glu Thr  Ile Gly Arg His Val  Leu Gly Ile Leu Asp  Arg Ser Ser 
    1760                 1765                 1770             


Lys Ser  Gln Ser Ser Ala Ser  Leu Ile Trp Arg Ser  Glu Ala Glu 
    1775                 1780                 1785             


Ala Ser  Val Lys Ser Cys Val  His Glu Glu His Thr  Arg Val Thr 
    1790                 1795                 1800             


Asp Glu  Ser Ile Pro Ser Tyr  Ser Gly Ser Asp Met  Pro Arg Asn 
    1805                 1810                 1815             


Asp Ile  Asn Met Trp Ser Lys  Val Thr Glu Glu Gly  Thr Glu Leu 
    1820                 1825                 1830             


Ser Gln  Arg Leu Val Arg Ser  Gly Phe Ala Gly Thr  Glu Ile Asp 
    1835                 1840                 1845             


Pro Glu  Asn Glu Glu Leu Met  Leu Asn Ile Ser Ser  Arg Leu Gln 
    1850                 1855                 1860             


Ala Ala  Val Glu Lys Leu Leu  Glu Ala Ile Ser Glu  Thr Ser Ser 
    1865                 1870                 1875             


Gln Leu  Glu His Ala Lys Val  Thr Gln Thr Glu Leu  Met Arg Glu 
    1880                 1885                 1890             


Ser Phe  Arg Gln Lys Gln Glu  Ala Thr Glu Ser Leu  Lys Cys Gln 
    1895                 1900                 1905             


Glu Glu  Leu Arg Glu Arg Leu  His Glu Glu Ser Arg  Ala Arg Glu 
    1910                 1915                 1920             


Gln Leu  Ala Val Glu Leu Ser  Lys Ala Glu Gly Val  Ile Asp Gly 
    1925                 1930                 1935             


Tyr Ala  Asp Glu Lys Thr Leu  Phe Glu Arg Gln Ile  Gln Glu Lys 
    1940                 1945                 1950             


Thr Asp  Ile Ile Asp Arg Leu  Glu Gln Glu Leu Leu  Cys Ala Ser 
    1955                 1960                 1965             


Asn Arg  Leu Gln Glu Leu Glu  Ala Glu Gln Gln Gln  Ile Gln Glu 
    1970                 1975                 1980             


Glu Arg  Glu Leu Leu Ser Arg  Gln Lys Glu Ala Met  Lys Ala Glu 
    1985                 1990                 1995             


Ala Gly  Pro Val Glu Gln Gln  Leu Leu Gln Glu Thr  Glu Lys Leu 
    2000                 2005                 2010             


Met Lys  Glu Lys Leu Glu Val  Gln Cys Gln Ala Glu  Lys Val Arg 
    2015                 2020                 2025             


Asp Asp  Leu Gln Lys Gln Val  Lys Ala Leu Glu Ile  Asp Val Glu 
    2030                 2035                 2040             


Glu Gln  Val Ser Arg Phe Ile  Glu Leu Glu Gln Glu  Lys Asn Thr 
    2045                 2050                 2055             


Glu Leu  Met Asp Leu Arg Gln  Gln Asn Gln Ala Leu  Glu Lys Gln 
    2060                 2065                 2070             


Leu Glu  Lys Met Arg Lys Phe  Leu Asp Glu Gln Ala  Ile Asp Arg 
    2075                 2080                 2085             


Glu His  Glu Arg Asp Val Phe  Gln Gln Glu Ile Gln  Lys Leu Glu 
    2090                 2095                 2100             


Gln Gln  Leu Lys Val Val Pro  Arg Phe Gln Pro Ile  Ser Glu His 
    2105                 2110                 2115             


Gln Thr  Arg Glu Val Glu Gln  Leu Ala Asn His Leu  Lys Glu Lys 
    2120                 2125                 2130             


Thr Asp  Lys Cys Ser Glu Leu  Leu Leu Ser Lys Glu  Gln Leu Gln 
    2135                 2140                 2145             


Arg Asp  Ile Gln Glu Arg Asn  Glu Glu Ile Glu Lys  Leu Glu Phe 
    2150                 2155                 2160             


Arg Val  Arg Glu Leu Glu Gln  Ala Leu Leu Val Ser  Ala Asp Thr 
    2165                 2170                 2175             


Phe Gln  Lys Val Glu Asp Arg  Lys His Phe Gly Ala  Val Glu Ala 
    2180                 2185                 2190             


Lys Pro  Glu Leu Ser Leu Glu  Val Gln Leu Gln Ala  Glu Arg Asp 
    2195                 2200                 2205             


Ala Ile  Asp Arg Lys Glu Lys  Glu Ile Thr Asn Leu  Glu Glu Gln 
    2210                 2215                 2220             


Leu Glu  Gln Phe Arg Glu Glu  Leu Glu Asn Lys Asn  Glu Glu Val 
    2225                 2230                 2235             


Gln Gln  Leu His Met Gln Leu  Glu Ile Gln Lys Lys  Glu Ser Thr 
    2240                 2245                 2250             


Thr Arg  Leu Gln Glu Leu Glu  Gln Glu Asn Lys Leu  Phe Lys Asp 
    2255                 2260                 2265             


Asp Met  Glu Lys Leu Gly Leu  Ala Ile Lys Glu Ser  Asp Ala Met 
    2270                 2275                 2280             


Ser Thr  Gln Asp Gln His Val  Leu Phe Gly Lys Phe  Ala Gln Ile 
    2285                 2290                 2295             


Ile Gln  Glu Lys Glu Val Glu  Ile Asp Gln Leu Asn  Glu Gln Val 
    2300                 2305                 2310             


Thr Lys  Leu Gln Gln Gln Leu  Lys Ile Thr Thr Asp  Asn Lys Val 
    2315                 2320                 2325             


Ile Glu  Glu Lys Asn Glu Leu  Ile Arg Asp Leu Glu  Thr Gln Ile 
    2330                 2335                 2340             


Glu Cys  Leu Met Ser Asp Gln  Glu Cys Val Lys Arg  Asn Arg Glu 
    2345                 2350                 2355             


Glu Glu  Ile Glu Gln Leu Asn  Glu Val Ile Glu Lys  Leu Gln Gln 
    2360                 2365                 2370             


Glu Leu  Ala Asn Ile Gly Gln  Lys Thr Ser Met Asn  Ala His Ser 
    2375                 2380                 2385             


Leu Ser  Glu Glu Ala Asp Ser  Leu Lys His Gln Leu  Asp Val Val 
    2390                 2395                 2400             


Ile Ala  Glu Lys Leu Ala Leu  Glu Gln Gln Val Glu  Thr Ala Asn 
    2405                 2410                 2415             


Glu Glu  Met Thr Phe Met Lys  Asn Val Leu Lys Glu  Thr Asn Phe 
    2420                 2425                 2430             


Lys Met  Asn Gln Leu Thr Gln  Glu Leu Phe Ser Leu  Lys Arg Glu 
    2435                 2440                 2445             


Arg Glu  Ser Val Glu Lys Ile  Gln Ser Ile Pro Glu  Asn Ser Val 
    2450                 2455                 2460             


Asn Val  Ala Ile Asp His Leu  Ser Lys Asp Lys Pro  Glu Leu Glu 
    2465                 2470                 2475             


Val Val  Leu Thr Glu Asp Ala  Leu Lys Ser Leu Glu  Asn Gln Thr 
    2480                 2485                 2490             


Tyr Phe  Lys Ser Phe Glu Glu  Asn Gly Lys Gly Ser  Ile Ile Asn 
    2495                 2500                 2505             


Leu Glu  Thr Arg Leu Leu Gln  Leu Glu Ser Thr Val  Ser Ala Lys 
    2510                 2515                 2520             


Asp Leu  Glu Leu Thr Gln Cys  Tyr Lys Gln Ile Lys  Asp Met Gln 
    2525                 2530                 2535             


Glu Gln  Gly Gln Phe Glu Thr  Glu Met Leu Gln Lys  Lys Ile Val 
    2540                 2545                 2550             


Asn Leu  Gln Lys Ile Val Glu  Glu Lys Val Ala Ala  Ala Leu Val 
    2555                 2560                 2565             


Ser Gln  Ile Gln Leu Glu Ala  Val Gln Glu Tyr Ala  Lys Phe Cys 
    2570                 2575                 2580             


Gln Asp  Asn Gln Thr Ile Ser  Ser Glu Pro Glu Arg  Thr Asn Ile 
    2585                 2590                 2595             


Gln Asn  Leu Asn Gln Leu Arg  Glu Asp Glu Leu Gly  Ser Asp Ile 
    2600                 2605                 2610             


Ser Ala  Leu Thr Leu Arg Ile  Ser Glu Leu Glu Ser  Gln Val Val 
    2615                 2620                 2625             


Glu Met  His Thr Ser Leu Ile  Leu Glu Lys Glu Gln  Val Glu Ile 
    2630                 2635                 2640             


Ala Glu  Lys Asn Val Leu Glu  Lys Glu Lys Lys Leu  Leu Glu Leu 
    2645                 2650                 2655             


Gln Lys  Leu Leu Glu Gly Asn  Glu Lys Lys Gln Arg  Glu Lys Glu 
    2660                 2665                 2670             


Lys Lys  Arg Ser Pro Gln Asp  Val Glu Val Leu Lys  Thr Thr Thr 
    2675                 2680                 2685             


Glu Leu  Phe His Ser Asn Glu  Glu Ser Gly Phe Phe  Asn Glu Leu 
    2690                 2695                 2700             


Glu Ala  Leu Arg Ala Glu Ser  Val Ala Thr Lys Ala  Glu Leu Ala 
    2705                 2710                 2715             


Ser Tyr  Lys Glu Lys Ala Glu  Lys Leu Gln Glu Glu  Leu Leu Val 
    2720                 2725                 2730             


Lys Glu  Thr Asn Met Thr Ser  Leu Gln Lys Asp Leu  Ser Gln Val 
    2735                 2740                 2745             


Arg Asp  His Leu Ala Glu Ala  Lys Glu Lys Leu Ser  Ile Leu Glu 
    2750                 2755                 2760             


Lys Glu  Asp Glu Thr Glu Val  Gln Glu Ser Lys Lys  Ala Cys Met 
    2765                 2770                 2775             


Phe Glu  Pro Leu Pro Ile Lys  Leu Ser Lys Ser Ile  Ala Ser Gln 
    2780                 2785                 2790             


Thr Asp  Gly Thr Leu Lys Ile  Ser Ser Ser Asn Gln  Thr Pro Gln 
    2795                 2800                 2805             


Ile Leu  Val Lys Asn Ala Gly  Ile Gln Ile Asn Leu  Gln Ser Glu 
    2810                 2815                 2820             


Cys Ser  Ser Glu Glu Val Thr  Glu Ile Ile Ser Gln  Phe Thr Glu 
    2825                 2830                 2835             


Lys Ile  Glu Lys Met Gln Glu  Leu His Ala Ala Glu  Ile Leu Asp 
    2840                 2845                 2850             


Met Glu  Ser Arg His Ile Ser  Glu Thr Glu Thr Leu  Lys Arg Glu 
    2855                 2860                 2865             


His Tyr  Val Ala Val Gln Leu  Leu Lys Glu Glu Cys  Gly Thr Leu 
    2870                 2875                 2880             


Lys Ala  Val Ile Gln Cys Leu  Arg Ser Lys Glu Val  Phe Gly Phe 
    2885                 2890                 2895             


Tyr Asn  Met Cys Phe Ser Thr  Leu Cys Asp Ser Gly  Ser Asp Trp 
    2900                 2905                 2910             


Gly Gln  Gly Ile Tyr Leu Thr  His Ser Gln Gly Phe  Asp Ile Ala 
    2915                 2920                 2925             


Ser Glu  Gly Arg Gly Glu Glu  Ser Glu Ser Ala Thr  Asp Ser Phe 
    2930                 2935                 2940             


Pro Lys  Lys Ile Lys Gly Leu  Leu Arg Ala Val His  Asn Glu Gly 
    2945                 2950                 2955             


Met Gln  Val Leu Ser Leu Thr  Glu Ser Pro Tyr Ser  Asp Gly Glu 
    2960                 2965                 2970             


Asp His  Ser Ile Gln Gln Val  Ser Glu Pro Trp Leu  Glu Glu Arg 
    2975                 2980                 2985             


Lys Ala  Tyr Ile Asn Thr Ile  Ser Ser Leu Lys Asp  Leu Ile Thr 
    2990                 2995                 3000             


Lys Met  Gln Leu Gln Arg Glu  Ala Glu Val Tyr Asp  Ser Ser Gln 
    3005                 3010                 3015             


Ser His  Glu Ser Phe Ser Asp  Trp Arg Gly Glu Leu  Leu Leu Ala 
    3020                 3025                 3030             


Leu Gln  Gln Val Phe Leu Glu  Glu Arg Ser Val Leu  Leu Ala Ala 
    3035                 3040                 3045             


Phe Arg  Thr Glu Leu Thr Ala  Leu Gly Thr Thr Asp  Ala Val Gly 
    3050                 3055                 3060             


Leu Leu  Asn Cys Leu Glu Gln  Arg Ile Gln Glu Gln  Gly Val Glu 
    3065                 3070                 3075             


Tyr Gln  Ala Ala Met Glu Cys  Leu Gln Lys Ala Asp  Arg Arg Ser 
    3080                 3085                 3090             


Leu Leu  Ser Glu Ile Gln Ala  Leu His Ala Gln Met  Asn Gly Arg 
    3095                 3100                 3105             


Lys Ile  Thr Leu Lys Arg Glu  Gln Glu Ser Glu Lys  Pro Ser Gln 
    3110                 3115                 3120             


Glu Leu  Leu Glu Tyr Asn Ile  Gln Gln Lys Gln Ser  Gln Met Leu 
    3125                 3130                 3135             


Glu Met  Gln Val Glu Leu Ser  Ser Met Lys Asp Arg  Ala Thr Glu 
    3140                 3145                 3150             


Leu Gln  Glu Gln Leu Ser Ser  Glu Lys Met Val Val  Ala Glu Leu 
    3155                 3160                 3165             


Lys Ser  Glu Leu Ala Gln Thr  Lys Leu Glu Leu Glu  Thr Thr Leu 
    3170                 3175                 3180             


Lys Ala  Gln His Lys His Leu  Lys Glu Leu Glu Ala  Phe Arg Leu 
    3185                 3190                 3195             


Glu Val  Lys Asp Lys Thr Asp  Glu Val His Leu Leu  Asn Asp Thr 
    3200                 3205                 3210             


Leu Ala  Ser Glu Gln Lys Lys  Ser Arg Glu Leu Gln  Trp Ala Leu 
    3215                 3220                 3225             


Glu Lys  Glu Lys Ala Lys Leu  Gly Arg Ser Glu Glu  Arg Asp Lys 
    3230                 3235                 3240             


Glu Glu  Leu Glu Asp Leu Lys  Phe Ser Leu Glu Ser  Gln Lys Gln 
    3245                 3250                 3255             


Arg Asn  Leu Gln Leu Asn Leu  Leu Leu Glu Gln Gln  Lys Gln Leu 
    3260                 3265                 3270             


Leu Asn  Glu Ser Gln Gln Lys  Ile Glu Ser Gln Arg  Met Leu Tyr 
    3275                 3280                 3285             


Asp Ala  Gln Leu Ser Glu Glu  Gln Gly Arg Asn Leu  Glu Leu Gln 
    3290                 3295                 3300             


Val Leu  Leu Glu Ser Glu Lys  Val Arg Ile Arg Glu  Met Ser Ser 
    3305                 3310                 3315             


Thr Leu  Asp Arg Glu Arg Glu  Leu His Ala Gln Leu  Gln Ser Ser 
    3320                 3325                 3330             


Asp Gly  Thr Gly Gln Ser Arg  Pro Pro Leu Pro Ser  Glu Asp Leu 
    3335                 3340                 3345             


Leu Lys  Glu Leu Gln Lys Gln  Leu Glu Glu Lys His  Ser Arg Ile 
    3350                 3355                 3360             


Val Glu  Leu Leu Asn Glu Thr  Glu Lys Tyr Lys Leu  Asp Ser Leu 
    3365                 3370                 3375             


Gln Thr  Arg Gln Gln Met Glu  Lys Asp Arg Gln Val  His Arg Lys 
    3380                 3385                 3390             


Thr Leu  Gln Thr Glu Gln Glu  Ala Asn Thr Glu Gly  Gln Lys Lys 
    3395                 3400                 3405             


Met His  Glu Leu Gln Ser Lys  Val Glu Asp Leu Gln  Arg Gln Leu 
    3410                 3415                 3420             


Glu Glu  Lys Arg Gln Gln Val  Tyr Lys Leu Asp Leu  Glu Gly Gln 
    3425                 3430                 3435             


Arg Leu  Gln Gly Ile Met Gln  Glu Phe Gln Lys Gln  Glu Leu Glu 
    3440                 3445                 3450             


Arg Glu  Glu Lys Arg Glu Ser  Arg Arg Ile Leu Tyr  Gln Asn Leu 
    3455                 3460                 3465             


Asn Glu  Pro Thr Thr Trp Ser  Leu Thr Ser Asp Arg  Thr Arg Asn 
    3470                 3475                 3480             


Trp Val  Leu Gln Gln Lys Ile  Glu Gly Glu Thr Lys  Glu Ser Asn 
    3485                 3490                 3495             


Tyr Ala  Lys Leu Ile Glu Met  Asn Gly Gly Gly Thr  Gly Cys Asn 
    3500                 3505                 3510             


His Glu  Leu Glu Met Ile Arg  Gln Lys Leu Gln Cys  Val Ala Ser 
    3515                 3520                 3525             


Lys Leu  Gln Val Leu Pro Gln  Lys Ala Ser Glu Arg  Leu Gln Phe 
    3530                 3535                 3540             


Glu Thr  Ala Asp Asp Glu Asp  Phe Ile Trp Val Gln  Glu Asn Ile 
    3545                 3550                 3555             


Asp Glu  Ile Ile Leu Gln Leu  Gln Lys Leu Thr Gly  Gln Gln Gly 
    3560                 3565                 3570             


Glu Glu  Pro Ser Leu Val Ser  Pro Ser Thr Ser Cys  Gly Ser Leu 
    3575                 3580                 3585             


Thr Glu  Arg Leu Leu Arg Gln  Asn Ala Glu Leu Thr  Gly His Ile 
    3590                 3595                 3600             


Ser Gln  Leu Thr Glu Glu Lys  Asn Asp Leu Arg Asn  Met Val Met 
    3605                 3610                 3615             


Lys Leu  Glu Glu Gln Ile Arg  Trp Tyr Arg Gln Thr  Gly Ala Gly 
    3620                 3625                 3630             


Arg Asp  Asn Ser Ser Arg Phe  Ser Leu Asn Gly Gly  Ala Asn Ile 
    3635                 3640                 3645             


Glu Ala  Ile Ile Ala Ser Glu  Lys Glu Val Trp Asn  Arg Glu Lys 
    3650                 3655                 3660             


Leu Thr  Leu Gln Lys Ser Leu  Lys Arg Ala Glu Ala  Glu Val Tyr 
    3665                 3670                 3675             


Lys Leu  Lys Ala Glu Leu Arg  Asn Asp Ser Leu Leu  Gln Thr Leu 
    3680                 3685                 3690             


Ser Pro  Asp Ser Glu His Val  Thr Leu Lys Arg Ile  Tyr Gly Lys 
    3695                 3700                 3705             


Tyr Leu  Arg Ala Glu Ser Phe  Arg Lys Ala Leu Ile  Tyr Gln Lys 
    3710                 3715                 3720             


Lys Tyr  Leu Leu Leu Leu Leu  Gly Gly Phe Gln Glu  Cys Glu Asp 
    3725                 3730                 3735             


Ala Thr  Leu Ala Leu Leu Ala  Arg Met Gly Gly Gln  Pro Ala Phe 
    3740                 3745                 3750             


Thr Asp  Leu Glu Val Ile Thr  Asn Arg Pro Lys Gly  Phe Thr Arg 
    3755                 3760                 3765             


Phe Arg  Ser Ala Val Arg Val  Ser Ile Ala Ile Ser  Arg Met Lys 
    3770                 3775                 3780             


Phe Leu  Val Arg Arg Trp His  Arg Val Thr Gly Ser  Val Ser Ile 
    3785                 3790                 3795             


Asn Ile  Asn Arg Asp Gly Phe  Gly Leu Asn Gln Gly  Ala Glu Lys 
    3800                 3805                 3810             


Thr Asp  Ser Phe Tyr His Ser  Ser Gly Gly Leu Glu  Leu Tyr Gly 
    3815                 3820                 3825             


Glu Pro  Arg His Thr Thr Tyr  Arg Ser Arg Ser Asp  Leu Asp Tyr 
    3830                 3835                 3840             


Ile Arg  Ser Pro Leu Pro Phe  Gln Asn Arg Tyr Pro  Gly Thr Pro 
    3845                 3850                 3855             


Ala Asp  Phe Asn Pro Gly Ser  Leu Ala Cys Ser Gln  Leu Gln Asn 
    3860                 3865                 3870             


Tyr Asp  Pro Asp Arg Ala Leu  Thr Asp Tyr Ile Thr  Arg Leu Glu 
    3875                 3880                 3885             


Ala Leu  Gln Arg Arg Leu Gly  Thr Ile Gln Ser Gly  Ser Thr Thr 
    3890                 3895                 3900             


Gln Phe  His Ala Gly Met Arg  Arg 
    3905                 3910     


<210>  515
<211>  1683
<212>  DNA
<213>  Homo sapiens

<400>  515
atggggaagt ggagaccgag aggctgctgc cggggaaata tgcagtgcag acaagaggtt       60

cctgctactc tcacctcatc agagttgttt tctaccagga accagcccca gccccagccc      120

cagcccctgc tggcagatgc tccggtaccc tgggctgtgg cttccaggat gtgcctgact      180

ccagggcagg gctgtggcca ccagggccag gacgagggtc cgctgccagc cccaagcccc      240

ccaccagcca tgagctcctc cagaaaggac cacctcggcg ccagcagctc agagcccctc      300

ccggtcatca ttgtgggtaa cggcccctct ggtatctgcc tgtcctacct gctctccggc      360

tacacaccct acacgaagcc agatgccatc cacccacacc ccctgctgca gaggaagctc      420

accgaggccc cgggggtctc catcctggac caggacctgg actacctgtc cgaaggcctc      480

gaaggccgat cccaaagccc cgtggccctg ctctttgatg cccttctacg cccagacaca      540

gactttgggg gaaacatgaa gtcggtcctc acctggaagc accggaagga gcacgccatc      600

ccccacgtgg ttctgggccg gaacctcccc gggggagcct ggcactccat cgaaggctcc      660

atggtgatcc tgagccaagg ccagtggatg gggctcccgg acctggaggt caaggactgg      720

atgcagaaga agcgaagagg tcttcgcaac agccgggcca ctgccgggga catcgcccac      780

tactacaggg actacgtggt caagaagggt ctggggcata actttgtgtc cggtgctgta      840

gtcacagccg tggagtgggg gacccccgat cccagcagct gtggggccca ggactccagc      900

cccctcttcc aggtgagcgg cttcctgacc aggaaccagg cccagcagcc cttctcgctg      960

tgggcccgca acgtggtcct cgccacaggc acgttcgaca gcccggcccg gctgggcatc     1020

cccggggagg ccctgccctt catccaccat gagctgtctg ccctggaggc cgccacaagg     1080

gtgggtgcgg tgaccccggc ctcagaccct gtcctcatca ttggcgcggg gctgtcagcg     1140

gccgacgcgg tcctctacgc ccgccactac aacatcccgg tgatccatgc cttccgccgg     1200

gccgtggacg accctggcct ggtgttcaac cagctgccca agatgctgta ccccgagtac     1260

cacaaggtgc accagatgat gcgggagcag tccatcctgt cgcccagccc ctatgagggt     1320

taccgcagcc tccccaggca ccagctgctg tgcttcaagg aagactgcca ggccgtgttc     1380

caggacctcg agggtgtcga gaaggtgttt ggggtctccc tggtgctggt cctcatcggc     1440

tcccaccccg acctctcctt cctgcctggg gcaggggctg actttgcagt ggatcctgac     1500

cagccgctga gcgccaagag gaaccccatt gacgtggacc ccttcaccta ccagagcacc     1560

cgccaggagg gcctgtacgc catggggccg ctggccgggg acaacttcgt gaggtttgtg     1620

caggggggcg ccttggctgt ggccagctcc ctgctaagga aggagaccag gaagccaccc     1680

taa                                                                   1683


<210>  516
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Gly Lys Trp Arg Pro Arg Gly Cys Cys Arg Gly Asn Met Gln Cys 
1               5                   10                  15      


Arg Gln Glu Val Pro Ala Thr Leu Thr Ser Ser Glu Leu Phe Ser Thr 
            20                  25                  30          


Arg Asn Gln Pro Gln Pro Gln Pro Gln Pro Leu Leu Ala Asp Ala Pro 
        35                  40                  45              


Val Pro Trp Ala Val Ala Ser Arg Met Cys Leu Thr Pro Gly Gln Gly 
    50                  55                  60                  


Cys Gly His Gln Gly Gln Asp Glu Gly Pro Leu Pro Ala Pro Ser Pro 
65                  70                  75                  80  


Pro Pro Ala Met Ser Ser Ser Arg Lys Asp His Leu Gly Ala Ser Ser 
                85                  90                  95      


Ser Glu Pro Leu Pro Val Ile Ile Val Gly Asn Gly Pro Ser Gly Ile 
            100                 105                 110         


Cys Leu Ser Tyr Leu Leu Ser Gly Tyr Thr Pro Tyr Thr Lys Pro Asp 
        115                 120                 125             


Ala Ile His Pro His Pro Leu Leu Gln Arg Lys Leu Thr Glu Ala Pro 
    130                 135                 140                 


Gly Val Ser Ile Leu Asp Gln Asp Leu Asp Tyr Leu Ser Glu Gly Leu 
145                 150                 155                 160 


Glu Gly Arg Ser Gln Ser Pro Val Ala Leu Leu Phe Asp Ala Leu Leu 
                165                 170                 175     


Arg Pro Asp Thr Asp Phe Gly Gly Asn Met Lys Ser Val Leu Thr Trp 
            180                 185                 190         


Lys His Arg Lys Glu His Ala Ile Pro His Val Val Leu Gly Arg Asn 
        195                 200                 205             


Leu Pro Gly Gly Ala Trp His Ser Ile Glu Gly Ser Met Val Ile Leu 
    210                 215                 220                 


Ser Gln Gly Gln Trp Met Gly Leu Pro Asp Leu Glu Val Lys Asp Trp 
225                 230                 235                 240 


Met Gln Lys Lys Arg Arg Gly Leu Arg Asn Ser Arg Ala Thr Ala Gly 
                245                 250                 255     


Asp Ile Ala His Tyr Tyr Arg Asp Tyr Val Val Lys Lys Gly Leu Gly 
            260                 265                 270         


His Asn Phe Val Ser Gly Ala Val Val Thr Ala Val Glu Trp Gly Thr 
        275                 280                 285             


Pro Asp Pro Ser Ser Cys Gly Ala Gln Asp Ser Ser Pro Leu Phe Gln 
    290                 295                 300                 


Val Ser Gly Phe Leu Thr Arg Asn Gln Ala Gln Gln Pro Phe Ser Leu 
305                 310                 315                 320 


Trp Ala Arg Asn Val Val Leu Ala Thr Gly Thr Phe Asp Ser Pro Ala 
                325                 330                 335     


Arg Leu Gly Ile Pro Gly Glu Ala Leu Pro Phe Ile His His Glu Leu 
            340                 345                 350         


Ser Ala Leu Glu Ala Ala Thr Arg Val Gly Ala Val Thr Pro Ala Ser 
        355                 360                 365             


Asp Pro Val Leu Ile Ile Gly Ala Gly Leu Ser Ala Ala Asp Ala Val 
    370                 375                 380                 


Leu Tyr Ala Arg His Tyr Asn Ile Pro Val Ile His Ala Phe Arg Arg 
385                 390                 395                 400 


Ala Val Asp Asp Pro Gly Leu Val Phe Asn Gln Leu Pro Lys Met Leu 
                405                 410                 415     


Tyr Pro Glu Tyr His Lys Val His Gln Met Met Arg Glu Gln Ser Ile 
            420                 425                 430         


Leu Ser Pro Ser Pro Tyr Glu Gly Tyr Arg Ser Leu Pro Arg His Gln 
        435                 440                 445             


Leu Leu Cys Phe Lys Glu Asp Cys Gln Ala Val Phe Gln Asp Leu Glu 
    450                 455                 460                 


Gly Val Glu Lys Val Phe Gly Val Ser Leu Val Leu Val Leu Ile Gly 
465                 470                 475                 480 


Ser His Pro Asp Leu Ser Phe Leu Pro Gly Ala Gly Ala Asp Phe Ala 
                485                 490                 495     


Val Asp Pro Asp Gln Pro Leu Ser Ala Lys Arg Asn Pro Ile Asp Val 
            500                 505                 510         


Asp Pro Phe Thr Tyr Gln Ser Thr Arg Gln Glu Gly Leu Tyr Ala Met 
        515                 520                 525             


Gly Pro Leu Ala Gly Asp Asn Phe Val Arg Phe Val Gln Gly Gly Ala 
    530                 535                 540                 


Leu Ala Val Ala Ser Ser Leu Leu Arg Lys Glu Thr Arg Lys Pro Pro 
545                 550                 555                 560 


<210>  517
<211>  2751
<212>  DNA
<213>  Homo sapiens

<400>  517
atgctgccac tgggctcaga gcccgccctg aatgagctgc tgcttcgcaa ggaggaggag       60

tggagggcgc tgcaggcaca ccgcacccag ctgcaggagg cggctctgca ggacacacgg      120

agccagctgg aggaggcgca ggggaaactg cggtgcctgc aggaggactt tgtctacaac      180

cttcaggtgc tggaggagcg ggacctcgag ctggagcgct atgacgccgc cttcgcccag      240

gccagggagt gggaggaggc caggcgggca gaggtgagcg agctcaagat agaggcagct      300

aagctgaggc aggcgctagc cagagaggcc aggaaggtgg aggagctgca gcagcagcag      360

cagctggcat tccaggagca tcgcctggag ctggagcgcg tccacagtga caagaatggt      420

gagattgacc accaccggga acagtatgaa aatctaaaat ggacactgga gagaaaactt      480

gaggagctcg acggtgagct tgctctgcag agacaggaac tgctgctgga gtttgaatcg      540

aaaatgcgga agagggagca cgaattccgt ctgcaggctg acaacatgag caacacagcc      600

ttgtcccggg agcttaaggt taaactactg cacaaagagc tggaggctct gaaggaagcc      660

ggggcaaagg ctgcagagag tctgcagagg gcagaggcca ccaacgccga gctggagagg      720

aagctccaga gccgagccgg ggagctccag gatctggagg ccatgagccg cgcccgggta      780

aaggatttag aggataaact tcactctgtg cagctaacca ggaagaagga agaggaaaca      840

tttaagagga agcatgagga gctcgaccgt ctggccaggg agaaggatgc agtgctggtg      900

gcggtgaagg gagcccacgt ggagcagctg caggagctgc agaccagggt tctggagctg      960

caggcccact gcgagaccct cgaggcgcag ctccgcaggg cagagtggag acaggctgac     1020

accgccaagg agaaggacgc tgccattgac caacttcgtg aagatgcatc aactgtaaaa     1080

tctgcctggg atgctcaaat tgctcaacta tctaaggaga tggtctccag agaccttcag     1140

attcagacgc tgcaggaaga agaggtgaag ctcaaggcac aggtggcccg atcccagcag     1200

gacattgaaa ggtacaagca acagctgtcc ctggcagtgg aaagggagcg gagcctggag     1260

cgtgatcagg tgcagctggg cctggactgg cagcgccgct gtgatgacat tgaaagggac     1320

cagatccaaa agtcagaggc cctgattcag ggtctgagca tggcaaaaag tcaggttgct     1380

gccaagctgc aggagacaga gcaggcgcta caggagcagg aggtggtgct gaaggccatg     1440

accctggaac gagaccaggc cgtgcaggcc ctgaggatgc atgggctccc cagaccaggg     1500

gcacagatgc ttctcaggca gcatgaagaa gaaataagta aagactttcc atccagtgag     1560

atccagcggc tccgagagca gaacacgagc ttgcgaaacg cgattgccca gatgaggaaa     1620

gaaatggagg ctctaagcca tcagattcct cctcccatcc agacagcggc agagagcaca     1680

gatgcaaacc agcctgaccc agaggctggg ggagatgccg ccactcctga ttatgttctg     1740

gcccttgaag cagaaatacg aactctaaag cataagttta aaactctgga aaagcatcta     1800

gaagatgtgt tggatccttt aaagatgtcc tcacctcatg ctgagtctca gcccagcgtc     1860

cgcacctcga cagagacgac tggagggtct gcccaagctg gtcaagccgg agggtctgtc     1920

caagctggtc aagcaggagg atctgtccaa gctggcccag tatcctctgg actggcactc     1980

aggaagctcg gggacagagt gcagctccta aacctgctgg tgacacgact cagacagaag     2040

gtgctgcggg aacccctgga gccggccgct ctccagcgtg agcttccccg tgaggtggac     2100

caggtacacc tggaggtttt ggagctgcgg aagcaggtgg ctgagctggg gaagcatctc     2160

aggatagccc agcacggggg agcggagcct tcaggcagga agcagccccc agcctcggac     2220

gccgtggccc ttgggagaga gcaggacgcc aagagtgccg aggatgaggc tccttccaga     2280

cacttgggaa agcaccagcc ccgctcagca caggtgggca gcagacttga cgccctgcaa     2340

ggcccgaaga cacaacacag catccacacg gtgacctgta aatcacctcg gcagaaagaa     2400

gacaggtccc caaagccacc ccaggctccc cagcaccctg aggagcatgg tcgccaatcc     2460

cacagctcct cctcctttgc cagtggcacc ctccaggaca tgtggaggtt gctagacctg     2520

ggatccagcc cttctggtgt cacctcccag ggtgactcaa ctccagagct cccagctcct     2580

ccagcagccg acaggaggcc cgtcaagatg caggcaggca ttgccacccc agggatgaag     2640

acagcagccc aggcaaaggc caagaccaca ggagcctccc ggtctcatcc tgcaaaagct     2700

aaaggctgcc agaggccccc caagatccgt aactacaaca ttatggactg a              2751


<210>  518
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Leu Pro Leu Gly Ser Glu Pro Ala Leu Asn Glu Leu Leu Leu Arg 
1               5                   10                  15      


Lys Glu Glu Glu Trp Arg Ala Leu Gln Ala His Arg Thr Gln Leu Gln 
            20                  25                  30          


Glu Ala Ala Leu Gln Asp Thr Arg Ser Gln Leu Glu Glu Ala Gln Gly 
        35                  40                  45              


Lys Leu Arg Cys Leu Gln Glu Asp Phe Val Tyr Asn Leu Gln Val Leu 
    50                  55                  60                  


Glu Glu Arg Asp Leu Glu Leu Glu Arg Tyr Asp Ala Ala Phe Ala Gln 
65                  70                  75                  80  


Ala Arg Glu Trp Glu Glu Ala Arg Arg Ala Glu Val Ser Glu Leu Lys 
                85                  90                  95      


Ile Glu Ala Ala Lys Leu Arg Gln Ala Leu Ala Arg Glu Ala Arg Lys 
            100                 105                 110         


Val Glu Glu Leu Gln Gln Gln Gln Gln Leu Ala Phe Gln Glu His Arg 
        115                 120                 125             


Leu Glu Leu Glu Arg Val His Ser Asp Lys Asn Gly Glu Ile Asp His 
    130                 135                 140                 


His Arg Glu Gln Tyr Glu Asn Leu Lys Trp Thr Leu Glu Arg Lys Leu 
145                 150                 155                 160 


Glu Glu Leu Asp Gly Glu Leu Ala Leu Gln Arg Gln Glu Leu Leu Leu 
                165                 170                 175     


Glu Phe Glu Ser Lys Met Arg Lys Arg Glu His Glu Phe Arg Leu Gln 
            180                 185                 190         


Ala Asp Asn Met Ser Asn Thr Ala Leu Ser Arg Glu Leu Lys Val Lys 
        195                 200                 205             


Leu Leu His Lys Glu Leu Glu Ala Leu Lys Glu Ala Gly Ala Lys Ala 
    210                 215                 220                 


Ala Glu Ser Leu Gln Arg Ala Glu Ala Thr Asn Ala Glu Leu Glu Arg 
225                 230                 235                 240 


Lys Leu Gln Ser Arg Ala Gly Glu Leu Gln Asp Leu Glu Ala Met Ser 
                245                 250                 255     


Arg Ala Arg Val Lys Asp Leu Glu Asp Lys Leu His Ser Val Gln Leu 
            260                 265                 270         


Thr Arg Lys Lys Glu Glu Glu Thr Phe Lys Arg Lys His Glu Glu Leu 
        275                 280                 285             


Asp Arg Leu Ala Arg Glu Lys Asp Ala Val Leu Val Ala Val Lys Gly 
    290                 295                 300                 


Ala His Val Glu Gln Leu Gln Glu Leu Gln Thr Arg Val Leu Glu Leu 
305                 310                 315                 320 


Gln Ala His Cys Glu Thr Leu Glu Ala Gln Leu Arg Arg Ala Glu Trp 
                325                 330                 335     


Arg Gln Ala Asp Thr Ala Lys Glu Lys Asp Ala Ala Ile Asp Gln Leu 
            340                 345                 350         


Arg Glu Asp Ala Ser Thr Val Lys Ser Ala Trp Asp Ala Gln Ile Ala 
        355                 360                 365             


Gln Leu Ser Lys Glu Met Val Ser Arg Asp Leu Gln Ile Gln Thr Leu 
    370                 375                 380                 


Gln Glu Glu Glu Val Lys Leu Lys Ala Gln Val Ala Arg Ser Gln Gln 
385                 390                 395                 400 


Asp Ile Glu Arg Tyr Lys Gln Gln Leu Ser Leu Ala Val Glu Arg Glu 
                405                 410                 415     


Arg Ser Leu Glu Arg Asp Gln Val Gln Leu Gly Leu Asp Trp Gln Arg 
            420                 425                 430         


Arg Cys Asp Asp Ile Glu Arg Asp Gln Ile Gln Lys Ser Glu Ala Leu 
        435                 440                 445             


Ile Gln Gly Leu Ser Met Ala Lys Ser Gln Val Ala Ala Lys Leu Gln 
    450                 455                 460                 


Glu Thr Glu Gln Ala Leu Gln Glu Gln Glu Val Val Leu Lys Ala Met 
465                 470                 475                 480 


Thr Leu Glu Arg Asp Gln Ala Val Gln Ala Leu Arg Met His Gly Leu 
                485                 490                 495     


Pro Arg Pro Gly Ala Gln Met Leu Leu Arg Gln His Glu Glu Glu Ile 
            500                 505                 510         


Ser Lys Asp Phe Pro Ser Ser Glu Ile Gln Arg Leu Arg Glu Gln Asn 
        515                 520                 525             


Thr Ser Leu Arg Asn Ala Ile Ala Gln Met Arg Lys Glu Met Glu Ala 
    530                 535                 540                 


Leu Ser His Gln Ile Pro Pro Pro Ile Gln Thr Ala Ala Glu Ser Thr 
545                 550                 555                 560 


Asp Ala Asn Gln Pro Asp Pro Glu Ala Gly Gly Asp Ala Ala Thr Pro 
                565                 570                 575     


Asp Tyr Val Leu Ala Leu Glu Ala Glu Ile Arg Thr Leu Lys His Lys 
            580                 585                 590         


Phe Lys Thr Leu Glu Lys His Leu Glu Asp Val Leu Asp Pro Leu Lys 
        595                 600                 605             


Met Ser Ser Pro His Ala Glu Ser Gln Pro Ser Val Arg Thr Ser Thr 
    610                 615                 620                 


Glu Thr Thr Gly Gly Ser Ala Gln Ala Gly Gln Ala Gly Gly Ser Val 
625                 630                 635                 640 


Gln Ala Gly Gln Ala Gly Gly Ser Val Gln Ala Gly Pro Val Ser Ser 
                645                 650                 655     


Gly Leu Ala Leu Arg Lys Leu Gly Asp Arg Val Gln Leu Leu Asn Leu 
            660                 665                 670         


Leu Val Thr Arg Leu Arg Gln Lys Val Leu Arg Glu Pro Leu Glu Pro 
        675                 680                 685             


Ala Ala Leu Gln Arg Glu Leu Pro Arg Glu Val Asp Gln Val His Leu 
    690                 695                 700                 


Glu Val Leu Glu Leu Arg Lys Gln Val Ala Glu Leu Gly Lys His Leu 
705                 710                 715                 720 


Arg Ile Ala Gln His Gly Gly Ala Glu Pro Ser Gly Arg Lys Gln Pro 
                725                 730                 735     


Pro Ala Ser Asp Ala Val Ala Leu Gly Arg Glu Gln Asp Ala Lys Ser 
            740                 745                 750         


Ala Glu Asp Glu Ala Pro Ser Arg His Leu Gly Lys His Gln Pro Arg 
        755                 760                 765             


Ser Ala Gln Val Gly Ser Arg Leu Asp Ala Leu Gln Gly Pro Lys Thr 
    770                 775                 780                 


Gln His Ser Ile His Thr Val Thr Cys Lys Ser Pro Arg Gln Lys Glu 
785                 790                 795                 800 


Asp Arg Ser Pro Lys Pro Pro Gln Ala Pro Gln His Pro Glu Glu His 
                805                 810                 815     


Gly Arg Gln Ser His Ser Ser Ser Ser Phe Ala Ser Gly Thr Leu Gln 
            820                 825                 830         


Asp Met Trp Arg Leu Leu Asp Leu Gly Ser Ser Pro Ser Gly Val Thr 
        835                 840                 845             


Ser Gln Gly Asp Ser Thr Pro Glu Leu Pro Ala Pro Pro Ala Ala Asp 
    850                 855                 860                 


Arg Arg Pro Val Lys Met Gln Ala Gly Ile Ala Thr Pro Gly Met Lys 
865                 870                 875                 880 


Thr Ala Ala Gln Ala Lys Ala Lys Thr Thr Gly Ala Ser Arg Ser His 
                885                 890                 895     


Pro Ala Lys Ala Lys Gly Cys Gln Arg Pro Pro Lys Ile Arg Asn Tyr 
            900                 905                 910         


Asn Ile Met Asp 
        915     


<210>  519
<211>  5097
<212>  DNA
<213>  Homo sapiens

<400>  519
atggtgggag aactccgcta cagggaattc agggtgcccc tggggcccgg cttacatgcc       60

tatcctgatg agctgatccg ccagcgcgtg ggccatgatg ggcatcctga gtaccagatc      120

cgttggctca tcctgcggcg tggcgatgag ggggacgggg gctctggcca agtggactgc      180

aaggctgagc acatcctgct gtggatgtcc aaggatgaga tctatgccaa ctgccacaag      240

atgctgggcg aggatggcca ggtcatcggg ccctcccagg agtctgcagg ggaggttggg      300

gccctggaca aatctgtgct ggaggagatg gaaaccgacg tgaagtccct cattcagaga      360

gcccttcggc agctggagga gtgtgtgggc actatccctc ctgctcctct acttcacact      420

gtccacgtgc tcagcgccta tgccagcatt gagcccctca ctggagtatt caaggaccca      480

agggtcctgg acttgctcat gcacatgttg agtagtcctg attatcagat tcgctggagt      540

gcaggccgga tgatacaagc cctgtcctcc catgacgctg ggacccggac tcagatcctt      600

ctgtcactga gccaacaaga agccattgag aaacacctgg attttgacag ccgctgtgct      660

ctgctagcac tgtttgcaca ggccacgctc tctgaacacc ccatgtcttt cgagggcatt      720

cagctaccac aggtcccagg aagggtgctc ttctccctgg tgaagcggta tttgcatgtc      780

acctcgctcc tggatcagct gaacgacagt gctgcggagc caggagccca gaacacctct      840

gctcctgagg agttgagtgg ggagaggggt caactggagc tggagttcag tatggccatg      900

ggcaccctga tctcggagct ggtgcaagcc atgcgctggg accaggcctc agacagacca      960

aggagctcag cacggtcccc cggttccatc ttccagcctc agctggcaga tgtgagccca     1020

gggctccccg ctgcccaggc tcagccctcc ttcaggaggt caagacgttt tcgccctcgt     1080

tctgagttcg caagtggcaa tacctatgct ttgtatgtgc gggacacact gcagccgggg     1140

atgcgagtgc ggatgctgga tgattatgag gagatcagtg ccggggatga gggcgagttt     1200

cggcagagca acaacggtgt gcctcctgtg caggtatttt gggagtcaac aggccgcacc     1260

tattgggtgc actggcacat gctggagatc ttgggctttg aggaagacat tgaggacatg     1320

gttgaggctg atgagtacca aggggcagtg gccagtagag tcctgggtag agccctgcct     1380

gcctggcgct ggaggcccat gacagaactc tatgctgtgc cttatgtgct gcctgaggat     1440

gaggacactg aggagtgtga acacctgacc ctggctgagt ggtgggaact cctcttcttc     1500

atcaagaagc tggatggacc tgaccatcag gaggttctcc agatcctcca ggagaaccta     1560

gatggggaga ttctggatga tgagatccta gctgaactgg ccgtgcccat agaattggcc     1620

caggacttgc tgctgactct gccacagcga ctcaatgaca gtgccctcag ggacctgatc     1680

aactgccatg tctacaagaa gtatgggcct gaagccctag cagggaacca agcctaccca     1740

tcccttctag aagcccaaga agatgtcctc ctgctagacg cgcaggccca ggctaaggac     1800

tcagaagatg cagccaaagt ggaagcaaaa gaacccccat ctcagagtcc caacactccc     1860

ctgcagcgtc tggtggaggg ttatggtcca gctgggaaaa tcctcctgga tctagagcaa     1920

gccctcagct cagaggggac ccaggagaac aaggtcaagc cactcctgct gcagctgcag     1980

cggcagccgc agcccttcct ggcactgatg cagagcctgg acactccgga gactaacagg     2040

accctgcacc tgactgtgct gagaatcctg aagcagctgg tggacttccc cgaggcactg     2100

ctgctcccct ggcacgaggc cgtggatgcc tgcatggcct gcctgcggtc cccaaacact     2160

gatcgagagg tgctccagga actgattttc ttcctgcacc gcctgacctc agtgagcagg     2220

gactatgccg tggtgctgaa tcagctggga gcaagagacg ctatctccaa ggccctggaa     2280

aagcacctgg gaaagctgga gctggctcag gagctgcggg acatggtgtt caagtgtgag     2340

aagcatgccc acctctaccg caaactcatc accaacatcc tgggaggctg catccagatg     2400

gtgctgggcc agatcgaaga ccacagacga acccaccaac ccatcaacat ccctttcttt     2460

gatgtgttcc tcagatacct gtgccagggc tccagtgtgg aagtgaagga ggacaagtgc     2520

tgggagaagg tggaggtgtc ctccaacccg caccgggcca gcaagctgac ggaccacaac     2580

cccaagacct attgggagtc caacggcagc gccggctccc actacatcac cctgcacatg     2640

cgccggggca tcctcatcag gcaactgact ctgcttgtgg ctagtgagga ctcgagttac     2700

atgccggccc gagtggtggt gtgcgggggt gatagcacta gctctcttca cacggaactc     2760

aactcggtga atgtgatgcc ctctgccagc cgggtgatcc tcctggagaa cctgacccgc     2820

ttctggccca tcatccagat ccgcataaag cgctgccagc agggtggcat tgatacgcgc     2880

attcgggggt tagagatcct aggccccaag cccacgttct ggccagtgtt ccgggagcag     2940

ctctgtcgtc acacacgcct cttctacatg gttcgggcac aggcctggag ccaggacatg     3000

gcagaggacc gcaggagcct cctgcacctg agttctagac tcaacggtgc tctgcgccag     3060

gagcagaatt ttgctgaccg cttcctccct gatgacgagg ctgcccaagc tctgggcaag     3120

acctgctggg aggccctggt cagccccgtg gtgcagaaca tcacctcccc tgatgaggat     3180

ggcattagcc ccctgggttg gctgctggac cagtacctgg agtgtcagga agctgtcttc     3240

aacccccaga gccgcggccc agctttcttc tcgcgggtgc gccgtctcac tcacctgctg     3300

gtgcatgtcg agccctgtga ggcaccccct cctgtggtgg ccactcctcg gcccaaaggc     3360

agaaacagaa gccacgactg gagctccttg gctacccggg gccttccaag cagcatcatg     3420

agaaacctga cgcgctgttg gcgggccgtg gtggagaagc aggtgaacaa ttttctgacc     3480

tcatcctggc gggatgatga ctttgtgcca cgctactgtg agcactttaa tattctgcag     3540

aactcaagct ctgaactgtt tgggcctcgg gcagccttct tgctggcgct gcaaaatggc     3600

tgtgcgggag ccttgctgaa gctccctttt ctcaaagctg cccacgtgag tgagcagttc     3660

gcccggcaca ttgaccagca gatccagggc agccggatcg gtggagccca ggaaatggag     3720

aggctggcac agctgcagca atgcctgcaa gctgtcctga ttttctccgg cttggagata     3780

gccaccactt ttgagcatta ttaccagcac tacatggcgg accgtctcct gggcgtggtc     3840

tcgagctggc tggagggggc cgtgctggag cagatcggtc cctgcttccc caaccgcctc     3900

ccccagcaga tgttgcagag cctgagcacc tctaaggagc tgcagcgcca gttccacgtc     3960

taccagctcc agcagctgga tcaggaactc ctgaagctgg aggatacaga gaagaaaata     4020

caggtgggcc ttggggccag tggcaaggag cacaagagcg agaaggaaga ggaagctggg     4080

gcagcagcag tggtggatgt ggcggaggga gaggaggaag aggaggagaa tgaggacctc     4140

tactatgaag gggcaatgcc agaagtgtct gtgcttgtcc tgtcccgaca ctcctggcct     4200

gttgcctcaa tctgccacac actgaacccc agaacctgcc tgccctccta cctgaggggc     4260

actttgaaca gatactccaa cttctacaac aagagtcaga gccaccctgc ccttgagcga     4320

ggctcacaga ggcgactgca gtggacgtgg ctgggctggg ctgagctgca gtttgggaac     4380

cagaccctgc atgtgtccac cgtgcagatg tggctactgc tgtatctcaa cgacctgaag     4440

gcggtctctg tggagagtct gctggcgttc tcagggctct ccgcagacat gctcaatcag     4500

gcgattgggc ccctcacctc ttcaagaggc cccctggacc ttcacgagca aaaggatata     4560

ccaggagggg tcctcaagat tcgagatggc agcaaggaac ccaggtcgag atgggacatt     4620

gtgcggctca tcccacctca gacgtacctg caagctgagg gtgaagacgg ccagaacttg     4680

gagaagagac ggaatcttct gaactgcctc atcgtccgaa tcctcaaggc ccatggagat     4740

gaggggctgc acattgacca gcttgtctgt ctggtgctgg aggcttggca gaagggcccg     4800

tgtcctccca ggggtttggt cagcagcctt ggtaaggggt ctgcatgcag cagcactgac     4860

gtcctctcct gcatcctaca cctcctgggc aagggcacgc tgagacgcca tgacgaccgg     4920

ccccaggtgc tgtcctatgc agtccctgtg actgtcatgg agcctcacac tgagtccctg     4980

aacccaggct cctcaggccc caacccaccc ctcaccttcc ataccctaca gattcgctcc     5040

cggggtgtgc cctatgcctc ctgcactgcc acccagagct tctctacctt ccggtag        5097


<210>  520
<211>  1698
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Val Gly Glu Leu Arg Tyr Arg Glu Phe Arg Val Pro Leu Gly Pro 
1               5                   10                  15      


Gly Leu His Ala Tyr Pro Asp Glu Leu Ile Arg Gln Arg Val Gly His 
            20                  25                  30          


Asp Gly His Pro Glu Tyr Gln Ile Arg Trp Leu Ile Leu Arg Arg Gly 
        35                  40                  45              


Asp Glu Gly Asp Gly Gly Ser Gly Gln Val Asp Cys Lys Ala Glu His 
    50                  55                  60                  


Ile Leu Leu Trp Met Ser Lys Asp Glu Ile Tyr Ala Asn Cys His Lys 
65                  70                  75                  80  


Met Leu Gly Glu Asp Gly Gln Val Ile Gly Pro Ser Gln Glu Ser Ala 
                85                  90                  95      


Gly Glu Val Gly Ala Leu Asp Lys Ser Val Leu Glu Glu Met Glu Thr 
            100                 105                 110         


Asp Val Lys Ser Leu Ile Gln Arg Ala Leu Arg Gln Leu Glu Glu Cys 
        115                 120                 125             


Val Gly Thr Ile Pro Pro Ala Pro Leu Leu His Thr Val His Val Leu 
    130                 135                 140                 


Ser Ala Tyr Ala Ser Ile Glu Pro Leu Thr Gly Val Phe Lys Asp Pro 
145                 150                 155                 160 


Arg Val Leu Asp Leu Leu Met His Met Leu Ser Ser Pro Asp Tyr Gln 
                165                 170                 175     


Ile Arg Trp Ser Ala Gly Arg Met Ile Gln Ala Leu Ser Ser His Asp 
            180                 185                 190         


Ala Gly Thr Arg Thr Gln Ile Leu Leu Ser Leu Ser Gln Gln Glu Ala 
        195                 200                 205             


Ile Glu Lys His Leu Asp Phe Asp Ser Arg Cys Ala Leu Leu Ala Leu 
    210                 215                 220                 


Phe Ala Gln Ala Thr Leu Ser Glu His Pro Met Ser Phe Glu Gly Ile 
225                 230                 235                 240 


Gln Leu Pro Gln Val Pro Gly Arg Val Leu Phe Ser Leu Val Lys Arg 
                245                 250                 255     


Tyr Leu His Val Thr Ser Leu Leu Asp Gln Leu Asn Asp Ser Ala Ala 
            260                 265                 270         


Glu Pro Gly Ala Gln Asn Thr Ser Ala Pro Glu Glu Leu Ser Gly Glu 
        275                 280                 285             


Arg Gly Gln Leu Glu Leu Glu Phe Ser Met Ala Met Gly Thr Leu Ile 
    290                 295                 300                 


Ser Glu Leu Val Gln Ala Met Arg Trp Asp Gln Ala Ser Asp Arg Pro 
305                 310                 315                 320 


Arg Ser Ser Ala Arg Ser Pro Gly Ser Ile Phe Gln Pro Gln Leu Ala 
                325                 330                 335     


Asp Val Ser Pro Gly Leu Pro Ala Ala Gln Ala Gln Pro Ser Phe Arg 
            340                 345                 350         


Arg Ser Arg Arg Phe Arg Pro Arg Ser Glu Phe Ala Ser Gly Asn Thr 
        355                 360                 365             


Tyr Ala Leu Tyr Val Arg Asp Thr Leu Gln Pro Gly Met Arg Val Arg 
    370                 375                 380                 


Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala Gly Asp Glu Gly Glu Phe 
385                 390                 395                 400 


Arg Gln Ser Asn Asn Gly Val Pro Pro Val Gln Val Phe Trp Glu Ser 
                405                 410                 415     


Thr Gly Arg Thr Tyr Trp Val His Trp His Met Leu Glu Ile Leu Gly 
            420                 425                 430         


Phe Glu Glu Asp Ile Glu Asp Met Val Glu Ala Asp Glu Tyr Gln Gly 
        435                 440                 445             


Ala Val Ala Ser Arg Val Leu Gly Arg Ala Leu Pro Ala Trp Arg Trp 
    450                 455                 460                 


Arg Pro Met Thr Glu Leu Tyr Ala Val Pro Tyr Val Leu Pro Glu Asp 
465                 470                 475                 480 


Glu Asp Thr Glu Glu Cys Glu His Leu Thr Leu Ala Glu Trp Trp Glu 
                485                 490                 495     


Leu Leu Phe Phe Ile Lys Lys Leu Asp Gly Pro Asp His Gln Glu Val 
            500                 505                 510         


Leu Gln Ile Leu Gln Glu Asn Leu Asp Gly Glu Ile Leu Asp Asp Glu 
        515                 520                 525             


Ile Leu Ala Glu Leu Ala Val Pro Ile Glu Leu Ala Gln Asp Leu Leu 
    530                 535                 540                 


Leu Thr Leu Pro Gln Arg Leu Asn Asp Ser Ala Leu Arg Asp Leu Ile 
545                 550                 555                 560 


Asn Cys His Val Tyr Lys Lys Tyr Gly Pro Glu Ala Leu Ala Gly Asn 
                565                 570                 575     


Gln Ala Tyr Pro Ser Leu Leu Glu Ala Gln Glu Asp Val Leu Leu Leu 
            580                 585                 590         


Asp Ala Gln Ala Gln Ala Lys Asp Ser Glu Asp Ala Ala Lys Val Glu 
        595                 600                 605             


Ala Lys Glu Pro Pro Ser Gln Ser Pro Asn Thr Pro Leu Gln Arg Leu 
    610                 615                 620                 


Val Glu Gly Tyr Gly Pro Ala Gly Lys Ile Leu Leu Asp Leu Glu Gln 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Gly Thr Gln Glu Asn Lys Val Lys Pro Leu Leu 
                645                 650                 655     


Leu Gln Leu Gln Arg Gln Pro Gln Pro Phe Leu Ala Leu Met Gln Ser 
            660                 665                 670         


Leu Asp Thr Pro Glu Thr Asn Arg Thr Leu His Leu Thr Val Leu Arg 
        675                 680                 685             


Ile Leu Lys Gln Leu Val Asp Phe Pro Glu Ala Leu Leu Leu Pro Trp 
    690                 695                 700                 


His Glu Ala Val Asp Ala Cys Met Ala Cys Leu Arg Ser Pro Asn Thr 
705                 710                 715                 720 


Asp Arg Glu Val Leu Gln Glu Leu Ile Phe Phe Leu His Arg Leu Thr 
                725                 730                 735     


Ser Val Ser Arg Asp Tyr Ala Val Val Leu Asn Gln Leu Gly Ala Arg 
            740                 745                 750         


Asp Ala Ile Ser Lys Ala Leu Glu Lys His Leu Gly Lys Leu Glu Leu 
        755                 760                 765             


Ala Gln Glu Leu Arg Asp Met Val Phe Lys Cys Glu Lys His Ala His 
    770                 775                 780                 


Leu Tyr Arg Lys Leu Ile Thr Asn Ile Leu Gly Gly Cys Ile Gln Met 
785                 790                 795                 800 


Val Leu Gly Gln Ile Glu Asp His Arg Arg Thr His Gln Pro Ile Asn 
                805                 810                 815     


Ile Pro Phe Phe Asp Val Phe Leu Arg Tyr Leu Cys Gln Gly Ser Ser 
            820                 825                 830         


Val Glu Val Lys Glu Asp Lys Cys Trp Glu Lys Val Glu Val Ser Ser 
        835                 840                 845             


Asn Pro His Arg Ala Ser Lys Leu Thr Asp His Asn Pro Lys Thr Tyr 
    850                 855                 860                 


Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile Thr Leu His Met 
865                 870                 875                 880 


Arg Arg Gly Ile Leu Ile Arg Gln Leu Thr Leu Leu Val Ala Ser Glu 
                885                 890                 895     


Asp Ser Ser Tyr Met Pro Ala Arg Val Val Val Cys Gly Gly Asp Ser 
            900                 905                 910         


Thr Ser Ser Leu His Thr Glu Leu Asn Ser Val Asn Val Met Pro Ser 
        915                 920                 925             


Ala Ser Arg Val Ile Leu Leu Glu Asn Leu Thr Arg Phe Trp Pro Ile 
    930                 935                 940                 


Ile Gln Ile Arg Ile Lys Arg Cys Gln Gln Gly Gly Ile Asp Thr Arg 
945                 950                 955                 960 


Ile Arg Gly Leu Glu Ile Leu Gly Pro Lys Pro Thr Phe Trp Pro Val 
                965                 970                 975     


Phe Arg Glu Gln Leu Cys Arg His Thr Arg Leu Phe Tyr Met Val Arg 
            980                 985                 990         


Ala Gln Ala Trp Ser Gln Asp Met  Ala Glu Asp Arg Arg  Ser Leu Leu 
        995                 1000                 1005             


His Leu  Ser Ser Arg Leu Asn  Gly Ala Leu Arg Gln  Glu Gln Asn 
    1010                 1015                 1020             


Phe Ala  Asp Arg Phe Leu Pro  Asp Asp Glu Ala Ala  Gln Ala Leu 
    1025                 1030                 1035             


Gly Lys  Thr Cys Trp Glu Ala  Leu Val Ser Pro Val  Val Gln Asn 
    1040                 1045                 1050             


Ile Thr  Ser Pro Asp Glu Asp  Gly Ile Ser Pro Leu  Gly Trp Leu 
    1055                 1060                 1065             


Leu Asp  Gln Tyr Leu Glu Cys  Gln Glu Ala Val Phe  Asn Pro Gln 
    1070                 1075                 1080             


Ser Arg  Gly Pro Ala Phe Phe  Ser Arg Val Arg Arg  Leu Thr His 
    1085                 1090                 1095             


Leu Leu  Val His Val Glu Pro  Cys Glu Ala Pro Pro  Pro Val Val 
    1100                 1105                 1110             


Ala Thr  Pro Arg Pro Lys Gly  Arg Asn Arg Ser His  Asp Trp Ser 
    1115                 1120                 1125             


Ser Leu  Ala Thr Arg Gly Leu  Pro Ser Ser Ile Met  Arg Asn Leu 
    1130                 1135                 1140             


Thr Arg  Cys Trp Arg Ala Val  Val Glu Lys Gln Val  Asn Asn Phe 
    1145                 1150                 1155             


Leu Thr  Ser Ser Trp Arg Asp  Asp Asp Phe Val Pro  Arg Tyr Cys 
    1160                 1165                 1170             


Glu His  Phe Asn Ile Leu Gln  Asn Ser Ser Ser Glu  Leu Phe Gly 
    1175                 1180                 1185             


Pro Arg  Ala Ala Phe Leu Leu  Ala Leu Gln Asn Gly  Cys Ala Gly 
    1190                 1195                 1200             


Ala Leu  Leu Lys Leu Pro Phe  Leu Lys Ala Ala His  Val Ser Glu 
    1205                 1210                 1215             


Gln Phe  Ala Arg His Ile Asp  Gln Gln Ile Gln Gly  Ser Arg Ile 
    1220                 1225                 1230             


Gly Gly  Ala Gln Glu Met Glu  Arg Leu Ala Gln Leu  Gln Gln Cys 
    1235                 1240                 1245             


Leu Gln  Ala Val Leu Ile Phe  Ser Gly Leu Glu Ile  Ala Thr Thr 
    1250                 1255                 1260             


Phe Glu  His Tyr Tyr Gln His  Tyr Met Ala Asp Arg  Leu Leu Gly 
    1265                 1270                 1275             


Val Val  Ser Ser Trp Leu Glu  Gly Ala Val Leu Glu  Gln Ile Gly 
    1280                 1285                 1290             


Pro Cys  Phe Pro Asn Arg Leu  Pro Gln Gln Met Leu  Gln Ser Leu 
    1295                 1300                 1305             


Ser Thr  Ser Lys Glu Leu Gln  Arg Gln Phe His Val  Tyr Gln Leu 
    1310                 1315                 1320             


Gln Gln  Leu Asp Gln Glu Leu  Leu Lys Leu Glu Asp  Thr Glu Lys 
    1325                 1330                 1335             


Lys Ile  Gln Val Gly Leu Gly  Ala Ser Gly Lys Glu  His Lys Ser 
    1340                 1345                 1350             


Glu Lys  Glu Glu Glu Ala Gly  Ala Ala Ala Val Val  Asp Val Ala 
    1355                 1360                 1365             


Glu Gly  Glu Glu Glu Glu Glu  Glu Asn Glu Asp Leu  Tyr Tyr Glu 
    1370                 1375                 1380             


Gly Ala  Met Pro Glu Val Ser  Val Leu Val Leu Ser  Arg His Ser 
    1385                 1390                 1395             


Trp Pro  Val Ala Ser Ile Cys  His Thr Leu Asn Pro  Arg Thr Cys 
    1400                 1405                 1410             


Leu Pro  Ser Tyr Leu Arg Gly  Thr Leu Asn Arg Tyr  Ser Asn Phe 
    1415                 1420                 1425             


Tyr Asn  Lys Ser Gln Ser His  Pro Ala Leu Glu Arg  Gly Ser Gln 
    1430                 1435                 1440             


Arg Arg  Leu Gln Trp Thr Trp  Leu Gly Trp Ala Glu  Leu Gln Phe 
    1445                 1450                 1455             


Gly Asn  Gln Thr Leu His Val  Ser Thr Val Gln Met  Trp Leu Leu 
    1460                 1465                 1470             


Leu Tyr  Leu Asn Asp Leu Lys  Ala Val Ser Val Glu  Ser Leu Leu 
    1475                 1480                 1485             


Ala Phe  Ser Gly Leu Ser Ala  Asp Met Leu Asn Gln  Ala Ile Gly 
    1490                 1495                 1500             


Pro Leu  Thr Ser Ser Arg Gly  Pro Leu Asp Leu His  Glu Gln Lys 
    1505                 1510                 1515             


Asp Ile  Pro Gly Gly Val Leu  Lys Ile Arg Asp Gly  Ser Lys Glu 
    1520                 1525                 1530             


Pro Arg  Ser Arg Trp Asp Ile  Val Arg Leu Ile Pro  Pro Gln Thr 
    1535                 1540                 1545             


Tyr Leu  Gln Ala Glu Gly Glu  Asp Gly Gln Asn Leu  Glu Lys Arg 
    1550                 1555                 1560             


Arg Asn  Leu Leu Asn Cys Leu  Ile Val Arg Ile Leu  Lys Ala His 
    1565                 1570                 1575             


Gly Asp  Glu Gly Leu His Ile  Asp Gln Leu Val Cys  Leu Val Leu 
    1580                 1585                 1590             


Glu Ala  Trp Gln Lys Gly Pro  Cys Pro Pro Arg Gly  Leu Val Ser 
    1595                 1600                 1605             


Ser Leu  Gly Lys Gly Ser Ala  Cys Ser Ser Thr Asp  Val Leu Ser 
    1610                 1615                 1620             


Cys Ile  Leu His Leu Leu Gly  Lys Gly Thr Leu Arg  Arg His Asp 
    1625                 1630                 1635             


Asp Arg  Pro Gln Val Leu Ser  Tyr Ala Val Pro Val  Thr Val Met 
    1640                 1645                 1650             


Glu Pro  His Thr Glu Ser Leu  Asn Pro Gly Ser Ser  Gly Pro Asn 
    1655                 1660                 1665             


Pro Pro  Leu Thr Phe His Thr  Leu Gln Ile Arg Ser  Arg Gly Val 
    1670                 1675                 1680             


Pro Tyr  Ala Ser Cys Thr Ala  Thr Gln Ser Phe Ser  Thr Phe Arg 
    1685                 1690                 1695             


<210>  521
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  521
ggggagcact gcctggctcc acgtgcctcc tggtctcagt atggcgctgt cctgggttct       60

tacagtcctg agcctcctac ctctgctgga agcccagatc ccattgtgtg ccaacctagt      120

accggtgccc atcaccaacg ccaccctgga ccggatcact ggcaagtggt tttatatcgc      180

atcggccttt cgaaacgagg agtacaataa gtcggttcag gagatccaag caaccttctt      240

ttactttacc cccaacaaga cagaggacac gatctttctc agagagtacc agacccgcca      300

gaaccagtgc ttctataact ccagttacct gaatgtccag cgggagaatg ggaccgtctc      360

cagatacgag ggaggccgag aacatgttgc tcacctgctg ttccttaggg acaccaagac      420

cttgatgttt ggttcctacc tggacgatga gaagaactgg gggctgtctt tctatgctga      480

caagccagag acgaccaagg agcaactggg agagttctac gaagctctcg actgcttgtg      540

cattcccagg tcagatgtca tgtacaccga ctggaaaaag gataagtgtg agccactgga      600

gaagcagcac gagaaggaga ggaaacagga ggagggggaa tcctagcagg acacagcctt      660

ggatcaggac agagacttgg gggccatcct gcccctccaa cccgacatgt gtacctcagc      720

tttttccctc acttgcatca ataaagcttc tgtgtttgga acagtaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaa                                                       795


<210>  522
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly 
            100                 105                 110         


Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu 
        115                 120                 125             


Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  523
<211>  11406
<212>  DNA
<213>  Homo sapiens

<400>  523
atgagcaccg acagtaactc actggcacgt gaatttctga ccgatgtcaa ccggctttgc       60

aatgcagtgg tccagagggt ggaggccagg gaggaagaag aggaggagac gcacatggca      120

acccttggac agtaccttgt ccatggtcga ggatttctat tacttaccaa gctaaattct      180

ataattgatc aggcattgac atgtagagaa gaactcctga ctcttcttct gtctctcctt      240

ccactggtat ggaagatacc tgtccaagaa gaaaaggcaa cagattttaa cctaccgctc      300

tcagcagata taatcctgac caaagaaaag aactcaagtt cacaaagatc cactcaggaa      360

aaattacatt tagaaggaag tgccctgtct agtcaggttt ctgcaaaagt aaatgttttt      420

cgaaaaagca gacgacagcg taaaattacc catcgctatt ctgtaagaga tgcaagaaag      480

acacagctct ccacctcaga ttcagaagcc aattcagatg aaaaaggcat agcaatgaat      540

aagcatagaa ggccccatct gctgcatcat tttttaacat cgtttcctaa acaagaccac      600

cccaaagcta aacttgaccg cttagcaacc aaagaacaga ctcctccaga tgctatggct      660

ttggaaaatt ccagagagat tattccaaga caggggtcaa acactgacat tttaagtgag      720

ccagctgcct tgtctgttat cagtaacatg aacaattctc catttgactt atgtcatgtt      780

ttgttatctt tattagaaaa agtttgtaag tttgacgtta ccttgaatca taattctcct      840

ttagcagcca gtgtagtgcc cacactaact gaattcctag caggctttgg ggactgctgc      900

agtctgagcg acaacttgga gagtcgagta gtttctgcag gttggaccga agaaccggtg      960

gctttgattc aaaggatgct ctttcgaaca gtgttgcatc ttctgtcagt agatgttagt     1020

actgcagaga tgatgccaga aaatcttagg aaaaatttaa ctgaattgct tagagcagct     1080

ttaaaaatta gaatatgcct agaaaagcag cctgaccctt ttgcaccaag acaaaagaaa     1140

acactgcagg aggttcagga agattttgtg ttttcaaagt atcgtcatag agcccttctt     1200

ttacctgagc ttttggaagg agttcttcag attctgatct gttgtcttca aagtgcagct     1260

tcaaatccct tctacttcag tcaagccatg gatttggttc aagaattcat tcagcatcat     1320

ggatttaatt tatttgaaac agcagttctt caaatggaat ggctggtttt aagagatgga     1380

gttcctcccg aggcctcaga gcatttgaaa gccctaataa atagtgtgat gaaaataatg     1440

agcactgtca aaaaagtgaa atcagagcaa cttcatcatt cgatgtgtac aagaaaaagg     1500

cacagacgat gtgaatattc tcattttatg catcatcacc gagatctctc aggtcttctg     1560

gtttcggctt ttaaaaacca ggtttccaaa aacccatttg aagagactgc agatggagat     1620

gtttattatc ctgagcggtg ctgttgcatt gcagtgtgtg cccatcagtg cttgcgctta     1680

ctacagcagg cttccttgag cagcacttgt gtccagatcc tatcgggtgt tcataacatt     1740

ggaatatgct gttgtatgga tcccaaatct gtaatcattc ctttgctcca tgcttttaaa     1800

ttgccagcac tgaaaaattt tcagcagcat atattgaata tccttaacaa acttattttg     1860

gatcagttag gaggagcaga gatatcacca aaaattaaaa aagcagcttg taatatttgt     1920

actgttgact ctgaccaact agcccaatta gaagagacac tgcagggaaa cttatgtgat     1980

gctgaactct cctcaagttt atccagtcct tcttacagat ttcaagggat cctgcccagc     2040

agtggatctg aagatttgtt gtggaaatgg gatgctttaa aggcttatca gaactttgtt     2100

tttgaagaag acagattaca tagtatacag attgcaaatc acatttgcaa tttaatccag     2160

aaaggcaata tagttgttca gtggaaatta tataattaca tatttaatcc tgtgctccaa     2220

agaggagttg aattagcaca tcattgtcaa cacctaagcg ttacttcagc tcaaagtcat     2280

gtatgtagcc atcataacca gtgcttgcct caggacgtgc ttcagattta tgtaaaaact     2340

ctgcctatcc tgcttaaatc cagggtaata agagatttgt ttttgagttg taatggagta     2400

agtcaaataa tcgaattaaa ttgcttaaat ggtattcgaa gtcattctct aaaagcattt     2460

gaaactctga taatcagcct aggggagcaa cagaaagatg cctcagttcc agatattgat     2520

gggatagaca ttgaacagaa ggagttgtcc tctgtacatg tgggtacttc ttttcatcat     2580

cagcaagctt attcagattc tcctcagagt ctcagcaaat tttatgctgg cctcaaagaa     2640

gcttatccaa agagacggaa gactgttaac caagatgttc atatcaacac aataaaccta     2700

ttcctctgtg tggctttttt atgcgtaagt aaagaagcag agtctgacag ggagtcggcc     2760

aatgactcag aagatacttc tggctatgac agcacagcca gcgagccttt aagtcatatg     2820

ctgccatgta tatctctcga gagccttgtc ttgccttctc ctgaacatat gcaccaagca     2880

gcagacattt ggtctatgtg tcgttggatc tacatgttga gttcagtgtt ccagaaacag     2940

ttttataggc ttggtggttt ccgagtatgc cataagttaa tatttatgat aatacagaaa     3000

ctgttcagaa gtcacaaaga ggagcaagga aaaaaggagg gagatacaag tgtaaatgaa     3060

aaccaggatt taaacagaat ttctcaacct aagagaacta tgaaggaaga tttattatct     3120

ttggctataa aaagtgaccc cataccatca gaactaggta gtctaaaaaa gagtgctgac     3180

agtttaggta aattagagtt acagcatatt tcttccataa atgtggaaga agtttcagct     3240

actgaagccg ctcccgagga agcaaagcta tttacaagtc aagaaagtga gacctcactt     3300

caaagtatac gacttttgga agcccttctg gccatttgtc ttcatggtgc cagaactagt     3360

caacagaaga tggaattgga gttacctaat cagaacttgt ctgtggaaag tatattattt     3420

gaaatgaggg accatctttc ccagtcaaag gtgattgaaa cacaactagc aaagccttta     3480

tttgatgccc tgcttcgagt tgccctcggg aattattcag cagattttga acataatgat     3540

gctatgactg agaagagtca tcaatctgca gaagaattgt catcccagcc tggtgatttt     3600

tcagaagaag ctgaggattc tcagtgttgt agttttaaac ttttagttga agaagaaggt     3660

tacgaagcag atagtgaaag caatcctgaa gatggcgaaa cccaggatga tggggtagac     3720

ttaaagtctg aaacagaagg tttcagtgca tcaagcagtc caaatgactt actcgaaaac     3780

ctcactcaag gggaaataat ttatcctgag atttgtatgc tggaattaaa tttgctttct     3840

gctagtaaag ccaaacttga tgtgcttgcc catgtatttg agagtttttt gaaaattatt     3900

aggcagaaag aaaagaatgt ttttctgctc atgcaacagg gaactgtgaa aaatctttta     3960

ggagggttct tgagtatttt aacacaggat gattctgatt ttcaagcatg ccagagagta     4020

ttggtggatc ttttggtatc tttgatgagt tcaagaacat gttcagaaga gctaaccctt     4080

cttttgagaa tatttctgga gaaatctcct tgtacaaaaa ttcttcttct gggtattctg     4140

aaaattattg aaagtgatac tactatgagc ccttcacagt atctaacctt ccctttactg     4200

cacgctccaa atttaagcaa cggtgtttca tcacaaaagt atcctgggat tttaaacagt     4260

aaggccatgg gtttattgag aagagcacga gtttcacgga gcaagaaaga ggctgataga     4320

gagagttttc cccatcggct gctttcatct tggcacatag ccccagtcca cctgccgttg     4380

ctggggcaaa actgctggcc acacctatca gaaggtttca gtgtttccct gtggtttaat     4440

gtggagtgta tccatgaagc tgagagtact acagaaaaag gaaagaagat aaagaaaaga     4500

aacaaatcat taattttacc agatagcagt tttgatggta cagagagcga cagaccagaa     4560

ggtgcagagt acataaatcc tggtgaaaga ctcatagaag aaggatgtat tcatataatt     4620

tcactgggat ccaaagcgtt gatgatccaa gtgtgggctg atccccacaa tgccactctt     4680

atctttcgtg tgtgcatgga ttcaaatgat gacatgaaag ctgttttact agcacaggtt     4740

gaatcacagg agaatatttt cctcccaagc aaatggcaac atttagtact cacctactta     4800

cagcagcccc aagggaaaag gaggattcat gggaaaatct ccatatgggt ctctggacag     4860

aggaagcctg atgttacttt ggattttatg cttccaagaa aaacaagttt gtcatctgat     4920

agcaataaaa cattttgcat gattggccat tgtttatcat cccaagaaga gtttttgcag     4980

ttggctggaa aatgggacct gggaaatttg cttctcttca acggagctaa ggttggttca     5040

caagaggcct tttatctgta tgcttgtgga cccaaccata catctgtaat gccatgtaag     5100

tatggcaagc cagtcaatga ctactccaaa tatattaata aagaaatttt gcgatgtgaa     5160

caaatcagag aactttttat gaccaagaaa gatgtggata ttggtctctt aattgaaagt     5220

ctttcagttg tttatacaac ttactgtcct gctcagtata ccatctatga accagtgatt     5280

agacttaaag gtcaaatgaa aacccaactc tctcaaagac ccttcagctc aaaagaagtt     5340

cagagcatct tattagaacc tcatcatcta aagaatctcc aacctactga atataaaact     5400

attcaaggca ttctgcacga aattggtgga actggcatat ttgtttttct ctttgccagg     5460

gttgttgaac tcagtagctg tgaagaaact caagcattag cactgcgagt tatactctca     5520

ttaattaaat acaaccaaca aagagtacat gaattagaaa attgtaatgg actttctatg     5580

attcatcagg tgttgatcaa acaaaaatgc attgttgggt tttacatttt gaagaccctt     5640

cttgaaggat gctgtggtga agatattatt tatatgaatg agaatggaga gtttaagttg     5700

gatgtagact ctaatgctat aatccaagat gttaagctgt tagaggaact attgcttgac     5760

tggaagatat ggagtaaagc agagcaaggt gtttgggaaa ctttgctagc agctctagaa     5820

gtcctcatca gagcagatca ccaccagcag atgtttaata ttaagcagtt attgaaagct     5880

caagtggttc atcactttct actgacttgt caggttttgc aggaatacaa agaggggcaa     5940

ctcacaccca tgccccgaga ggtttgtaga tcatttgtga aaattatagc agaagtcctt     6000

ggatctcctc cagatttgga attattgaca attatcttca atttcctttt agcagttcac     6060

cctcctacta atacttacgt ttgtcacaat cccacgaact tctacttttc tttgcacata     6120

gatggcaaga tctttcagga gaaagtgcgg tcaatcatgt acctgaggca ttccagcagt     6180

ggaggaaggt cccttatgag ccctggattt atggtaataa gcccatctgg ttttactgct     6240

tcaccatatg aaggagagaa ttcctctaat attattccac aacagatggc cgcccatatg     6300

ctgcgttcta gaagcctacc agcattccct acttcttcac tactaacgca atcacaaaaa     6360

ctgactggaa gtttgggttg tagtatcgac aggttacaaa atattgcaga tacttatgtt     6420

gccacccaat caaagaaaca aaattctttg gggagttccg acacactgaa aaaaggcaaa     6480

gaggacgcat tcatcagtag ctgtgagtct gcaaaaactg tttgtgaaat ggaagctgtc     6540

ctctcagccc aggtctctgt cagtgatgtc ccaaagggag tgctgggatt tccagtggtc     6600

aaagcagatc ataaacagtt gggagcagaa cccaggtcag aagatgacag tcctggggat     6660

gagtcctgcc cacgccgacc tgattaccta aagggattgg cctccttcca gcgaagccac     6720

agcactattg caagccttgg gctagctttt ccttcacaga acggatctgc agctgttggc     6780

cgttggccaa gtcttgttga tagaaacact gatgattggg aaaactttgc ctattctctt     6840

ggttatgagc caaattacaa ccgaactgca agtgctcaca gtgtaactga agactgtttg     6900

gtacctatat gctgtggatt atatgaactc ctaagtgggg ttcttcttat cctgcctgat     6960

gttttgcttg aagatgtgat ggacaagctt attcaagcag atacactttt ggtcctcgtt     7020

aaccacccat caccagctat acaacaaggt gttattaaac tattagatgc atattttgct     7080

agagcatcta aggaacaaaa agataaattt ctgaagaatc gtggattttc cttgctagcc     7140

aaccagttgt atcttcatcg aggaactcaa gaattgttag aatgcttcat cgaaatgttc     7200

tttggtcgac atattggcct tgatgaagaa tttgatctgg aagatgtgag aaacatggga     7260

ttgtttcaga agtggtctgt cattcctatt ctgggactaa tagagacctc tctatatgac     7320

aacatactct tgcataatgc tcttttactt cttctccaaa ttttaaattc ttgttctaag     7380

gtagcagata tgttgctgga taatggtcta ctctatgtgt tatgtaatac agtagcagcc     7440

ctgaatggat tagaaaagaa cattcccatg agtgaatata aattgcttgc ttgtgatata     7500

cagcaacttt tcatagcagt tacaattcat gcttgcagtt cctcaggctc acaatatttt     7560

agggttattg aagaccttat tgtaatgctt ggatatcttc aaaatagcaa aaacaagagg     7620

acacaaaata tggctgttgc actacagctt agagttctcc aggctgctat ggaatttata     7680

aggaccaccg caaatcatga ctctgaaaac ctcacagatt cactccagtc accttctgct     7740

ccccatcatg cagtagttca aaagcggaaa agcattgctg gtcctcgaaa atttcccctt     7800

gctcaaactg aatcgcttct gatgaaaatg cgttcagtgg caaatgatga gcttcatgtg     7860

atgatgcaac ggagaatgag ccaagagaac cctagccaag caactgaaac ggaacttgcg     7920

cagagactac agaggctcac tgttttagca gtcaacagga ttatttatca agaatttaat     7980

tcagacatta ttgacatttt gagaactcca gaaaatgtaa ctcaaagcaa gacctcagtt     8040

ttccagaccg aaatttctga ggaaaatatt catcatgaac agtcttctgt tttcaatcca     8100

tttcagaaag aaatttttac atatctggta gaaggattca aagtatctat tggttcaagt     8160

aaagccagtg gttccaagca gcaatggact aaaattctgt ggtcttgtaa ggagaccttc     8220

cgaatgcagc ttgggagact actagtgcat attttgtcgc cagcccacgc tgcacaagag     8280

agaaagcaaa tttttgaaat agttcatgaa ccaaatcatc aggaaatact acgagactgt     8340

ctcagcccat ccctacaaca tggagccaag ttagttttgt atttgtcaga gttgatacat     8400

aatcaccaag gtgaattgac tgaagaagag ctaggcacag cagaactgct tatgaatgct     8460

ttgaagttat gtggtcacaa gtgcatccct cccagtgcat caacaaaagc agaccttatt     8520

aaaatgatca aagaggaaca aaagaaatat gaaactgaag aaggagtgaa taaagctgct     8580

tggcagaaaa cagttaacaa taatcaacaa agtctctttc agcgtctgga ttcaaaatca     8640

aaggatatat ctaaaatagc tgcagatatc acccaggcag tgtctctctc ccaaggaaat     8700

gagagaaaaa aggtgatcca gcatattaga ggaatgtata aagtagattt gagtgccagc     8760

agacattggc aggaacttat tcagcagctg acacatgata gagcagtatg gtatgacccc     8820

atctactatc caacctcatg gcagttggat ccaacagaag ggccaaatcg agagaggaga     8880

cgtttacaga gatgttattt aactattcca aataagtatc tccttaggga tagacagaaa     8940

tcagaagatg ttgtcaaacc accactctct tacctgtttg aagacaaaac tcattcttct     9000

ttctcttcta ctgtcaaaga caaagctgca agtgaatcta taagagtgaa tcgaagatgc     9060

atcagtgttg caccatctag agagacagct ggtgaattgt tactaggtaa atgtggaatg     9120

tattttgtgg aagataatgc ttctgataca gttgaaagtt cgagccttca gggagagttg     9180

gaaccagcat cattttcctg gacatatgaa gaaattaaag aagttcacaa gcgttggtgg     9240

caattgagag ataatgctgt agaaatcttt ctaacaaatg gcagaacact cctgttggca     9300

tttgataaca ccaaggttcg tgatgatgta taccacaata tactcacaaa taacctccct     9360

aatcttctgg aatatggtaa catcaccgct ctgacaaatt tatggtatac tgggcaaatt     9420

actaattttg aatatttgac tcacttaaac aaacatgctg gccgatcctt caatgatctc     9480

atgcagtatc ctgtgttccc atttatactt gctgactacg ttagtgagac acttgacctc     9540

aatgatctgt tgatatacag aaatctctct aaacctatag ctgttcagta taaagaaaaa     9600

gaagatcgtt atgtggacac atacaagtac ttggaggaag agtaccgcaa aggagccaga     9660

gaagatgacc ccatgcctcc cgtgcagccc tatcactatg gctcccacta ttccaatagc     9720

ggcactgtgc ttcacttcct ggtcaggatg cctcctttca ctaaaatgtt tttagcctat     9780

caagatcaaa gttttgacat tccagacaga acttttcatt ctacaaatac aacttggcga     9840

ctctcatctt ttgaatctat gactgatgtg aaagaactta tcccagagtt tttctatctt     9900

ccagagttcc tagttaaccg tgaaggtttt gattttggtg tgcgtcagaa tggtgaacgg     9960

gttaatcacg tcaaccttcc cccttgggcg cgtaatgatc ctcgtctttt tatcctcatc    10020

catcggcagg ctctagagtc tgactacgtg tcgcagaaca tctgtcagtg gattgacttg    10080

gtgtttgggt ataagcaaaa ggggaaggct tctgttcaag cgatcaatgt ttttcatcct    10140

gctacatatt ttggaatgga tgtctctgca gttgaagatc cagttcagag acgagcgcta    10200

gaaaccatga taaaaaccta cgggcagact ccccgtcagc tgttccacat ggcccatgtg    10260

agcagacctg gagccaagct caatattgaa ggagagcttc cagctgctgt ggggttgcta    10320

gtgcagtttg ctttcaggga gacccgagaa caggtcaaag aaatcaccta tccgagtcct    10380

ttgtcatgga taaaaggctt gaaatggggg gaatacgtgg gttcccccag tgctccagta    10440

cctgtggtct gcttcagcca gccccacgga gaaagatttg gctctctcca ggctctgccc    10500

accagagcaa tctgtggttt gtcacggaat ttctgtcttc tgatgacata tagcaaggaa    10560

caaggtgtga gaagcatgaa cagtacggac attcagtggt cagccatcct gagctgggga    10620

tatgctgata atattttaag gttgaagagt aaacaaagtg agcctccagt aaactttatt    10680

caaagttcac aacagtacca ggtgactagt tgtgcttggg tgcctgacag ttgccagctg    10740

tttactggaa gcaaatgcgg tgtcatcaca gcctacacaa acagatttac aagcagcacg    10800

ccatcagaaa tagaaatgga gactcaaata catctctatg gtcacacaga agagataacc    10860

agcttatttg tttgcaaacc atacagtata ctgataagtg tgagcagaga cggaacctgc    10920

atcatatggg atttaaacag gttatgctat gtacaaagtc tggcgggaca caaaagccct    10980

gtcacagctg tctctgccag tgaaacctca ggtgatattg ctactgtgtg tgattcagct    11040

ggcggaggca gtgacctcag actctggacg gtgaacgggg atctcgttgg acatgtccac    11100

tgcagggaga tcatctgttc cgtggctttc tccaaccagc ctgagggagt atctatcaat    11160

gtaatcgctg ggggattaga aaatggaatt gtaaggttat ggagcacatg ggacttaaag    11220

cctgtgagag aaattacatt tcccaaatca aataagccca tcatcagcct tacattttct    11280

tgtgatggcc accatttgta cacagcaaac agtgatggga ccgtgattgc ctggtgtcgg    11340

aaggaccagc agcgcttgaa acagccaatg ttctattcct tccttagcag ctatgcagcc    11400

gggtga                                                               11406


<210>  524
<211>  3801
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Ser Thr Asp Ser Asn Ser Leu Ala Arg Glu Phe Leu Thr Asp Val 
1               5                   10                  15      


Asn Arg Leu Cys Asn Ala Val Val Gln Arg Val Glu Ala Arg Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Thr His Met Ala Thr Leu Gly Gln Tyr Leu Val His 
        35                  40                  45              


Gly Arg Gly Phe Leu Leu Leu Thr Lys Leu Asn Ser Ile Ile Asp Gln 
    50                  55                  60                  


Ala Leu Thr Cys Arg Glu Glu Leu Leu Thr Leu Leu Leu Ser Leu Leu 
65                  70                  75                  80  


Pro Leu Val Trp Lys Ile Pro Val Gln Glu Glu Lys Ala Thr Asp Phe 
                85                  90                  95      


Asn Leu Pro Leu Ser Ala Asp Ile Ile Leu Thr Lys Glu Lys Asn Ser 
            100                 105                 110         


Ser Ser Gln Arg Ser Thr Gln Glu Lys Leu His Leu Glu Gly Ser Ala 
        115                 120                 125             


Leu Ser Ser Gln Val Ser Ala Lys Val Asn Val Phe Arg Lys Ser Arg 
    130                 135                 140                 


Arg Gln Arg Lys Ile Thr His Arg Tyr Ser Val Arg Asp Ala Arg Lys 
145                 150                 155                 160 


Thr Gln Leu Ser Thr Ser Asp Ser Glu Ala Asn Ser Asp Glu Lys Gly 
                165                 170                 175     


Ile Ala Met Asn Lys His Arg Arg Pro His Leu Leu His His Phe Leu 
            180                 185                 190         


Thr Ser Phe Pro Lys Gln Asp His Pro Lys Ala Lys Leu Asp Arg Leu 
        195                 200                 205             


Ala Thr Lys Glu Gln Thr Pro Pro Asp Ala Met Ala Leu Glu Asn Ser 
    210                 215                 220                 


Arg Glu Ile Ile Pro Arg Gln Gly Ser Asn Thr Asp Ile Leu Ser Glu 
225                 230                 235                 240 


Pro Ala Ala Leu Ser Val Ile Ser Asn Met Asn Asn Ser Pro Phe Asp 
                245                 250                 255     


Leu Cys His Val Leu Leu Ser Leu Leu Glu Lys Val Cys Lys Phe Asp 
            260                 265                 270         


Val Thr Leu Asn His Asn Ser Pro Leu Ala Ala Ser Val Val Pro Thr 
        275                 280                 285             


Leu Thr Glu Phe Leu Ala Gly Phe Gly Asp Cys Cys Ser Leu Ser Asp 
    290                 295                 300                 


Asn Leu Glu Ser Arg Val Val Ser Ala Gly Trp Thr Glu Glu Pro Val 
305                 310                 315                 320 


Ala Leu Ile Gln Arg Met Leu Phe Arg Thr Val Leu His Leu Leu Ser 
                325                 330                 335     


Val Asp Val Ser Thr Ala Glu Met Met Pro Glu Asn Leu Arg Lys Asn 
            340                 345                 350         


Leu Thr Glu Leu Leu Arg Ala Ala Leu Lys Ile Arg Ile Cys Leu Glu 
        355                 360                 365             


Lys Gln Pro Asp Pro Phe Ala Pro Arg Gln Lys Lys Thr Leu Gln Glu 
    370                 375                 380                 


Val Gln Glu Asp Phe Val Phe Ser Lys Tyr Arg His Arg Ala Leu Leu 
385                 390                 395                 400 


Leu Pro Glu Leu Leu Glu Gly Val Leu Gln Ile Leu Ile Cys Cys Leu 
                405                 410                 415     


Gln Ser Ala Ala Ser Asn Pro Phe Tyr Phe Ser Gln Ala Met Asp Leu 
            420                 425                 430         


Val Gln Glu Phe Ile Gln His His Gly Phe Asn Leu Phe Glu Thr Ala 
        435                 440                 445             


Val Leu Gln Met Glu Trp Leu Val Leu Arg Asp Gly Val Pro Pro Glu 
    450                 455                 460                 


Ala Ser Glu His Leu Lys Ala Leu Ile Asn Ser Val Met Lys Ile Met 
465                 470                 475                 480 


Ser Thr Val Lys Lys Val Lys Ser Glu Gln Leu His His Ser Met Cys 
                485                 490                 495     


Thr Arg Lys Arg His Arg Arg Cys Glu Tyr Ser His Phe Met His His 
            500                 505                 510         


His Arg Asp Leu Ser Gly Leu Leu Val Ser Ala Phe Lys Asn Gln Val 
        515                 520                 525             


Ser Lys Asn Pro Phe Glu Glu Thr Ala Asp Gly Asp Val Tyr Tyr Pro 
    530                 535                 540                 


Glu Arg Cys Cys Cys Ile Ala Val Cys Ala His Gln Cys Leu Arg Leu 
545                 550                 555                 560 


Leu Gln Gln Ala Ser Leu Ser Ser Thr Cys Val Gln Ile Leu Ser Gly 
                565                 570                 575     


Val His Asn Ile Gly Ile Cys Cys Cys Met Asp Pro Lys Ser Val Ile 
            580                 585                 590         


Ile Pro Leu Leu His Ala Phe Lys Leu Pro Ala Leu Lys Asn Phe Gln 
        595                 600                 605             


Gln His Ile Leu Asn Ile Leu Asn Lys Leu Ile Leu Asp Gln Leu Gly 
    610                 615                 620                 


Gly Ala Glu Ile Ser Pro Lys Ile Lys Lys Ala Ala Cys Asn Ile Cys 
625                 630                 635                 640 


Thr Val Asp Ser Asp Gln Leu Ala Gln Leu Glu Glu Thr Leu Gln Gly 
                645                 650                 655     


Asn Leu Cys Asp Ala Glu Leu Ser Ser Ser Leu Ser Ser Pro Ser Tyr 
            660                 665                 670         


Arg Phe Gln Gly Ile Leu Pro Ser Ser Gly Ser Glu Asp Leu Leu Trp 
        675                 680                 685             


Lys Trp Asp Ala Leu Lys Ala Tyr Gln Asn Phe Val Phe Glu Glu Asp 
    690                 695                 700                 


Arg Leu His Ser Ile Gln Ile Ala Asn His Ile Cys Asn Leu Ile Gln 
705                 710                 715                 720 


Lys Gly Asn Ile Val Val Gln Trp Lys Leu Tyr Asn Tyr Ile Phe Asn 
                725                 730                 735     


Pro Val Leu Gln Arg Gly Val Glu Leu Ala His His Cys Gln His Leu 
            740                 745                 750         


Ser Val Thr Ser Ala Gln Ser His Val Cys Ser His His Asn Gln Cys 
        755                 760                 765             


Leu Pro Gln Asp Val Leu Gln Ile Tyr Val Lys Thr Leu Pro Ile Leu 
    770                 775                 780                 


Leu Lys Ser Arg Val Ile Arg Asp Leu Phe Leu Ser Cys Asn Gly Val 
785                 790                 795                 800 


Ser Gln Ile Ile Glu Leu Asn Cys Leu Asn Gly Ile Arg Ser His Ser 
                805                 810                 815     


Leu Lys Ala Phe Glu Thr Leu Ile Ile Ser Leu Gly Glu Gln Gln Lys 
            820                 825                 830         


Asp Ala Ser Val Pro Asp Ile Asp Gly Ile Asp Ile Glu Gln Lys Glu 
        835                 840                 845             


Leu Ser Ser Val His Val Gly Thr Ser Phe His His Gln Gln Ala Tyr 
    850                 855                 860                 


Ser Asp Ser Pro Gln Ser Leu Ser Lys Phe Tyr Ala Gly Leu Lys Glu 
865                 870                 875                 880 


Ala Tyr Pro Lys Arg Arg Lys Thr Val Asn Gln Asp Val His Ile Asn 
                885                 890                 895     


Thr Ile Asn Leu Phe Leu Cys Val Ala Phe Leu Cys Val Ser Lys Glu 
            900                 905                 910         


Ala Glu Ser Asp Arg Glu Ser Ala Asn Asp Ser Glu Asp Thr Ser Gly 
        915                 920                 925             


Tyr Asp Ser Thr Ala Ser Glu Pro Leu Ser His Met Leu Pro Cys Ile 
    930                 935                 940                 


Ser Leu Glu Ser Leu Val Leu Pro Ser Pro Glu His Met His Gln Ala 
945                 950                 955                 960 


Ala Asp Ile Trp Ser Met Cys Arg Trp Ile Tyr Met Leu Ser Ser Val 
                965                 970                 975     


Phe Gln Lys Gln Phe Tyr Arg Leu Gly Gly Phe Arg Val Cys His Lys 
            980                 985                 990         


Leu Ile Phe Met Ile Ile Gln Lys  Leu Phe Arg Ser His  Lys Glu Glu 
        995                 1000                 1005             


Gln Gly  Lys Lys Glu Gly Asp  Thr Ser Val Asn Glu  Asn Gln Asp 
    1010                 1015                 1020             


Leu Asn  Arg Ile Ser Gln Pro  Lys Arg Thr Met Lys  Glu Asp Leu 
    1025                 1030                 1035             


Leu Ser  Leu Ala Ile Lys Ser  Asp Pro Ile Pro Ser  Glu Leu Gly 
    1040                 1045                 1050             


Ser Leu  Lys Lys Ser Ala Asp  Ser Leu Gly Lys Leu  Glu Leu Gln 
    1055                 1060                 1065             


His Ile  Ser Ser Ile Asn Val  Glu Glu Val Ser Ala  Thr Glu Ala 
    1070                 1075                 1080             


Ala Pro  Glu Glu Ala Lys Leu  Phe Thr Ser Gln Glu  Ser Glu Thr 
    1085                 1090                 1095             


Ser Leu  Gln Ser Ile Arg Leu  Leu Glu Ala Leu Leu  Ala Ile Cys 
    1100                 1105                 1110             


Leu His  Gly Ala Arg Thr Ser  Gln Gln Lys Met Glu  Leu Glu Leu 
    1115                 1120                 1125             


Pro Asn  Gln Asn Leu Ser Val  Glu Ser Ile Leu Phe  Glu Met Arg 
    1130                 1135                 1140             


Asp His  Leu Ser Gln Ser Lys  Val Ile Glu Thr Gln  Leu Ala Lys 
    1145                 1150                 1155             


Pro Leu  Phe Asp Ala Leu Leu  Arg Val Ala Leu Gly  Asn Tyr Ser 
    1160                 1165                 1170             


Ala Asp  Phe Glu His Asn Asp  Ala Met Thr Glu Lys  Ser His Gln 
    1175                 1180                 1185             


Ser Ala  Glu Glu Leu Ser Ser  Gln Pro Gly Asp Phe  Ser Glu Glu 
    1190                 1195                 1200             


Ala Glu  Asp Ser Gln Cys Cys  Ser Phe Lys Leu Leu  Val Glu Glu 
    1205                 1210                 1215             


Glu Gly  Tyr Glu Ala Asp Ser  Glu Ser Asn Pro Glu  Asp Gly Glu 
    1220                 1225                 1230             


Thr Gln  Asp Asp Gly Val Asp  Leu Lys Ser Glu Thr  Glu Gly Phe 
    1235                 1240                 1245             


Ser Ala  Ser Ser Ser Pro Asn  Asp Leu Leu Glu Asn  Leu Thr Gln 
    1250                 1255                 1260             


Gly Glu  Ile Ile Tyr Pro Glu  Ile Cys Met Leu Glu  Leu Asn Leu 
    1265                 1270                 1275             


Leu Ser  Ala Ser Lys Ala Lys  Leu Asp Val Leu Ala  His Val Phe 
    1280                 1285                 1290             


Glu Ser  Phe Leu Lys Ile Ile  Arg Gln Lys Glu Lys  Asn Val Phe 
    1295                 1300                 1305             


Leu Leu  Met Gln Gln Gly Thr  Val Lys Asn Leu Leu  Gly Gly Phe 
    1310                 1315                 1320             


Leu Ser  Ile Leu Thr Gln Asp  Asp Ser Asp Phe Gln  Ala Cys Gln 
    1325                 1330                 1335             


Arg Val  Leu Val Asp Leu Leu  Val Ser Leu Met Ser  Ser Arg Thr 
    1340                 1345                 1350             


Cys Ser  Glu Glu Leu Thr Leu  Leu Leu Arg Ile Phe  Leu Glu Lys 
    1355                 1360                 1365             


Ser Pro  Cys Thr Lys Ile Leu  Leu Leu Gly Ile Leu  Lys Ile Ile 
    1370                 1375                 1380             


Glu Ser  Asp Thr Thr Met Ser  Pro Ser Gln Tyr Leu  Thr Phe Pro 
    1385                 1390                 1395             


Leu Leu  His Ala Pro Asn Leu  Ser Asn Gly Val Ser  Ser Gln Lys 
    1400                 1405                 1410             


Tyr Pro  Gly Ile Leu Asn Ser  Lys Ala Met Gly Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ala Arg  Val Ser Arg Ser Lys  Lys Glu Ala Asp Arg  Glu Ser Phe 
    1430                 1435                 1440             


Pro His  Arg Leu Leu Ser Ser  Trp His Ile Ala Pro  Val His Leu 
    1445                 1450                 1455             


Pro Leu  Leu Gly Gln Asn Cys  Trp Pro His Leu Ser  Glu Gly Phe 
    1460                 1465                 1470             


Ser Val  Ser Leu Trp Phe Asn  Val Glu Cys Ile His  Glu Ala Glu 
    1475                 1480                 1485             


Ser Thr  Thr Glu Lys Gly Lys  Lys Ile Lys Lys Arg  Asn Lys Ser 
    1490                 1495                 1500             


Leu Ile  Leu Pro Asp Ser Ser  Phe Asp Gly Thr Glu  Ser Asp Arg 
    1505                 1510                 1515             


Pro Glu  Gly Ala Glu Tyr Ile  Asn Pro Gly Glu Arg  Leu Ile Glu 
    1520                 1525                 1530             


Glu Gly  Cys Ile His Ile Ile  Ser Leu Gly Ser Lys  Ala Leu Met 
    1535                 1540                 1545             


Ile Gln  Val Trp Ala Asp Pro  His Asn Ala Thr Leu  Ile Phe Arg 
    1550                 1555                 1560             


Val Cys  Met Asp Ser Asn Asp  Asp Met Lys Ala Val  Leu Leu Ala 
    1565                 1570                 1575             


Gln Val  Glu Ser Gln Glu Asn  Ile Phe Leu Pro Ser  Lys Trp Gln 
    1580                 1585                 1590             


His Leu  Val Leu Thr Tyr Leu  Gln Gln Pro Gln Gly  Lys Arg Arg 
    1595                 1600                 1605             


Ile His  Gly Lys Ile Ser Ile  Trp Val Ser Gly Gln  Arg Lys Pro 
    1610                 1615                 1620             


Asp Val  Thr Leu Asp Phe Met  Leu Pro Arg Lys Thr  Ser Leu Ser 
    1625                 1630                 1635             


Ser Asp  Ser Asn Lys Thr Phe  Cys Met Ile Gly His  Cys Leu Ser 
    1640                 1645                 1650             


Ser Gln  Glu Glu Phe Leu Gln  Leu Ala Gly Lys Trp  Asp Leu Gly 
    1655                 1660                 1665             


Asn Leu  Leu Leu Phe Asn Gly  Ala Lys Val Gly Ser  Gln Glu Ala 
    1670                 1675                 1680             


Phe Tyr  Leu Tyr Ala Cys Gly  Pro Asn His Thr Ser  Val Met Pro 
    1685                 1690                 1695             


Cys Lys  Tyr Gly Lys Pro Val  Asn Asp Tyr Ser Lys  Tyr Ile Asn 
    1700                 1705                 1710             


Lys Glu  Ile Leu Arg Cys Glu  Gln Ile Arg Glu Leu  Phe Met Thr 
    1715                 1720                 1725             


Lys Lys  Asp Val Asp Ile Gly  Leu Leu Ile Glu Ser  Leu Ser Val 
    1730                 1735                 1740             


Val Tyr  Thr Thr Tyr Cys Pro  Ala Gln Tyr Thr Ile  Tyr Glu Pro 
    1745                 1750                 1755             


Val Ile  Arg Leu Lys Gly Gln  Met Lys Thr Gln Leu  Ser Gln Arg 
    1760                 1765                 1770             


Pro Phe  Ser Ser Lys Glu Val  Gln Ser Ile Leu Leu  Glu Pro His 
    1775                 1780                 1785             


His Leu  Lys Asn Leu Gln Pro  Thr Glu Tyr Lys Thr  Ile Gln Gly 
    1790                 1795                 1800             


Ile Leu  His Glu Ile Gly Gly  Thr Gly Ile Phe Val  Phe Leu Phe 
    1805                 1810                 1815             


Ala Arg  Val Val Glu Leu Ser  Ser Cys Glu Glu Thr  Gln Ala Leu 
    1820                 1825                 1830             


Ala Leu  Arg Val Ile Leu Ser  Leu Ile Lys Tyr Asn  Gln Gln Arg 
    1835                 1840                 1845             


Val His  Glu Leu Glu Asn Cys  Asn Gly Leu Ser Met  Ile His Gln 
    1850                 1855                 1860             


Val Leu  Ile Lys Gln Lys Cys  Ile Val Gly Phe Tyr  Ile Leu Lys 
    1865                 1870                 1875             


Thr Leu  Leu Glu Gly Cys Cys  Gly Glu Asp Ile Ile  Tyr Met Asn 
    1880                 1885                 1890             


Glu Asn  Gly Glu Phe Lys Leu  Asp Val Asp Ser Asn  Ala Ile Ile 
    1895                 1900                 1905             


Gln Asp  Val Lys Leu Leu Glu  Glu Leu Leu Leu Asp  Trp Lys Ile 
    1910                 1915                 1920             


Trp Ser  Lys Ala Glu Gln Gly  Val Trp Glu Thr Leu  Leu Ala Ala 
    1925                 1930                 1935             


Leu Glu  Val Leu Ile Arg Ala  Asp His His Gln Gln  Met Phe Asn 
    1940                 1945                 1950             


Ile Lys  Gln Leu Leu Lys Ala  Gln Val Val His His  Phe Leu Leu 
    1955                 1960                 1965             


Thr Cys  Gln Val Leu Gln Glu  Tyr Lys Glu Gly Gln  Leu Thr Pro 
    1970                 1975                 1980             


Met Pro  Arg Glu Val Cys Arg  Ser Phe Val Lys Ile  Ile Ala Glu 
    1985                 1990                 1995             


Val Leu  Gly Ser Pro Pro Asp  Leu Glu Leu Leu Thr  Ile Ile Phe 
    2000                 2005                 2010             


Asn Phe  Leu Leu Ala Val His  Pro Pro Thr Asn Thr  Tyr Val Cys 
    2015                 2020                 2025             


His Asn  Pro Thr Asn Phe Tyr  Phe Ser Leu His Ile  Asp Gly Lys 
    2030                 2035                 2040             


Ile Phe  Gln Glu Lys Val Arg  Ser Ile Met Tyr Leu  Arg His Ser 
    2045                 2050                 2055             


Ser Ser  Gly Gly Arg Ser Leu  Met Ser Pro Gly Phe  Met Val Ile 
    2060                 2065                 2070             


Ser Pro  Ser Gly Phe Thr Ala  Ser Pro Tyr Glu Gly  Glu Asn Ser 
    2075                 2080                 2085             


Ser Asn  Ile Ile Pro Gln Gln  Met Ala Ala His Met  Leu Arg Ser 
    2090                 2095                 2100             


Arg Ser  Leu Pro Ala Phe Pro  Thr Ser Ser Leu Leu  Thr Gln Ser 
    2105                 2110                 2115             


Gln Lys  Leu Thr Gly Ser Leu  Gly Cys Ser Ile Asp  Arg Leu Gln 
    2120                 2125                 2130             


Asn Ile  Ala Asp Thr Tyr Val  Ala Thr Gln Ser Lys  Lys Gln Asn 
    2135                 2140                 2145             


Ser Leu  Gly Ser Ser Asp Thr  Leu Lys Lys Gly Lys  Glu Asp Ala 
    2150                 2155                 2160             


Phe Ile  Ser Ser Cys Glu Ser  Ala Lys Thr Val Cys  Glu Met Glu 
    2165                 2170                 2175             


Ala Val  Leu Ser Ala Gln Val  Ser Val Ser Asp Val  Pro Lys Gly 
    2180                 2185                 2190             


Val Leu  Gly Phe Pro Val Val  Lys Ala Asp His Lys  Gln Leu Gly 
    2195                 2200                 2205             


Ala Glu  Pro Arg Ser Glu Asp  Asp Ser Pro Gly Asp  Glu Ser Cys 
    2210                 2215                 2220             


Pro Arg  Arg Pro Asp Tyr Leu  Lys Gly Leu Ala Ser  Phe Gln Arg 
    2225                 2230                 2235             


Ser His  Ser Thr Ile Ala Ser  Leu Gly Leu Ala Phe  Pro Ser Gln 
    2240                 2245                 2250             


Asn Gly  Ser Ala Ala Val Gly  Arg Trp Pro Ser Leu  Val Asp Arg 
    2255                 2260                 2265             


Asn Thr  Asp Asp Trp Glu Asn  Phe Ala Tyr Ser Leu  Gly Tyr Glu 
    2270                 2275                 2280             


Pro Asn  Tyr Asn Arg Thr Ala  Ser Ala His Ser Val  Thr Glu Asp 
    2285                 2290                 2295             


Cys Leu  Val Pro Ile Cys Cys  Gly Leu Tyr Glu Leu  Leu Ser Gly 
    2300                 2305                 2310             


Val Leu  Leu Ile Leu Pro Asp  Val Leu Leu Glu Asp  Val Met Asp 
    2315                 2320                 2325             


Lys Leu  Ile Gln Ala Asp Thr  Leu Leu Val Leu Val  Asn His Pro 
    2330                 2335                 2340             


Ser Pro  Ala Ile Gln Gln Gly  Val Ile Lys Leu Leu  Asp Ala Tyr 
    2345                 2350                 2355             


Phe Ala  Arg Ala Ser Lys Glu  Gln Lys Asp Lys Phe  Leu Lys Asn 
    2360                 2365                 2370             


Arg Gly  Phe Ser Leu Leu Ala  Asn Gln Leu Tyr Leu  His Arg Gly 
    2375                 2380                 2385             


Thr Gln  Glu Leu Leu Glu Cys  Phe Ile Glu Met Phe  Phe Gly Arg 
    2390                 2395                 2400             


His Ile  Gly Leu Asp Glu Glu  Phe Asp Leu Glu Asp  Val Arg Asn 
    2405                 2410                 2415             


Met Gly  Leu Phe Gln Lys Trp  Ser Val Ile Pro Ile  Leu Gly Leu 
    2420                 2425                 2430             


Ile Glu  Thr Ser Leu Tyr Asp  Asn Ile Leu Leu His  Asn Ala Leu 
    2435                 2440                 2445             


Leu Leu  Leu Leu Gln Ile Leu  Asn Ser Cys Ser Lys  Val Ala Asp 
    2450                 2455                 2460             


Met Leu  Leu Asp Asn Gly Leu  Leu Tyr Val Leu Cys  Asn Thr Val 
    2465                 2470                 2475             


Ala Ala  Leu Asn Gly Leu Glu  Lys Asn Ile Pro Met  Ser Glu Tyr 
    2480                 2485                 2490             


Lys Leu  Leu Ala Cys Asp Ile  Gln Gln Leu Phe Ile  Ala Val Thr 
    2495                 2500                 2505             


Ile His  Ala Cys Ser Ser Ser  Gly Ser Gln Tyr Phe  Arg Val Ile 
    2510                 2515                 2520             


Glu Asp  Leu Ile Val Met Leu  Gly Tyr Leu Gln Asn  Ser Lys Asn 
    2525                 2530                 2535             


Lys Arg  Thr Gln Asn Met Ala  Val Ala Leu Gln Leu  Arg Val Leu 
    2540                 2545                 2550             


Gln Ala  Ala Met Glu Phe Ile  Arg Thr Thr Ala Asn  His Asp Ser 
    2555                 2560                 2565             


Glu Asn  Leu Thr Asp Ser Leu  Gln Ser Pro Ser Ala  Pro His His 
    2570                 2575                 2580             


Ala Val  Val Gln Lys Arg Lys  Ser Ile Ala Gly Pro  Arg Lys Phe 
    2585                 2590                 2595             


Pro Leu  Ala Gln Thr Glu Ser  Leu Leu Met Lys Met  Arg Ser Val 
    2600                 2605                 2610             


Ala Asn  Asp Glu Leu His Val  Met Met Gln Arg Arg  Met Ser Gln 
    2615                 2620                 2625             


Glu Asn  Pro Ser Gln Ala Thr  Glu Thr Glu Leu Ala  Gln Arg Leu 
    2630                 2635                 2640             


Gln Arg  Leu Thr Val Leu Ala  Val Asn Arg Ile Ile  Tyr Gln Glu 
    2645                 2650                 2655             


Phe Asn  Ser Asp Ile Ile Asp  Ile Leu Arg Thr Pro  Glu Asn Val 
    2660                 2665                 2670             


Thr Gln  Ser Lys Thr Ser Val  Phe Gln Thr Glu Ile  Ser Glu Glu 
    2675                 2680                 2685             


Asn Ile  His His Glu Gln Ser  Ser Val Phe Asn Pro  Phe Gln Lys 
    2690                 2695                 2700             


Glu Ile  Phe Thr Tyr Leu Val  Glu Gly Phe Lys Val  Ser Ile Gly 
    2705                 2710                 2715             


Ser Ser  Lys Ala Ser Gly Ser  Lys Gln Gln Trp Thr  Lys Ile Leu 
    2720                 2725                 2730             


Trp Ser  Cys Lys Glu Thr Phe  Arg Met Gln Leu Gly  Arg Leu Leu 
    2735                 2740                 2745             


Val His  Ile Leu Ser Pro Ala  His Ala Ala Gln Glu  Arg Lys Gln 
    2750                 2755                 2760             


Ile Phe  Glu Ile Val His Glu  Pro Asn His Gln Glu  Ile Leu Arg 
    2765                 2770                 2775             


Asp Cys  Leu Ser Pro Ser Leu  Gln His Gly Ala Lys  Leu Val Leu 
    2780                 2785                 2790             


Tyr Leu  Ser Glu Leu Ile His  Asn His Gln Gly Glu  Leu Thr Glu 
    2795                 2800                 2805             


Glu Glu  Leu Gly Thr Ala Glu  Leu Leu Met Asn Ala  Leu Lys Leu 
    2810                 2815                 2820             


Cys Gly  His Lys Cys Ile Pro  Pro Ser Ala Ser Thr  Lys Ala Asp 
    2825                 2830                 2835             


Leu Ile  Lys Met Ile Lys Glu  Glu Gln Lys Lys Tyr  Glu Thr Glu 
    2840                 2845                 2850             


Glu Gly  Val Asn Lys Ala Ala  Trp Gln Lys Thr Val  Asn Asn Asn 
    2855                 2860                 2865             


Gln Gln  Ser Leu Phe Gln Arg  Leu Asp Ser Lys Ser  Lys Asp Ile 
    2870                 2875                 2880             


Ser Lys  Ile Ala Ala Asp Ile  Thr Gln Ala Val Ser  Leu Ser Gln 
    2885                 2890                 2895             


Gly Asn  Glu Arg Lys Lys Val  Ile Gln His Ile Arg  Gly Met Tyr 
    2900                 2905                 2910             


Lys Val  Asp Leu Ser Ala Ser  Arg His Trp Gln Glu  Leu Ile Gln 
    2915                 2920                 2925             


Gln Leu  Thr His Asp Arg Ala  Val Trp Tyr Asp Pro  Ile Tyr Tyr 
    2930                 2935                 2940             


Pro Thr  Ser Trp Gln Leu Asp  Pro Thr Glu Gly Pro  Asn Arg Glu 
    2945                 2950                 2955             


Arg Arg  Arg Leu Gln Arg Cys  Tyr Leu Thr Ile Pro  Asn Lys Tyr 
    2960                 2965                 2970             


Leu Leu  Arg Asp Arg Gln Lys  Ser Glu Asp Val Val  Lys Pro Pro 
    2975                 2980                 2985             


Leu Ser  Tyr Leu Phe Glu Asp  Lys Thr His Ser Ser  Phe Ser Ser 
    2990                 2995                 3000             


Thr Val  Lys Asp Lys Ala Ala  Ser Glu Ser Ile Arg  Val Asn Arg 
    3005                 3010                 3015             


Arg Cys  Ile Ser Val Ala Pro  Ser Arg Glu Thr Ala  Gly Glu Leu 
    3020                 3025                 3030             


Leu Leu  Gly Lys Cys Gly Met  Tyr Phe Val Glu Asp  Asn Ala Ser 
    3035                 3040                 3045             


Asp Thr  Val Glu Ser Ser Ser  Leu Gln Gly Glu Leu  Glu Pro Ala 
    3050                 3055                 3060             


Ser Phe  Ser Trp Thr Tyr Glu  Glu Ile Lys Glu Val  His Lys Arg 
    3065                 3070                 3075             


Trp Trp  Gln Leu Arg Asp Asn  Ala Val Glu Ile Phe  Leu Thr Asn 
    3080                 3085                 3090             


Gly Arg  Thr Leu Leu Leu Ala  Phe Asp Asn Thr Lys  Val Arg Asp 
    3095                 3100                 3105             


Asp Val  Tyr His Asn Ile Leu  Thr Asn Asn Leu Pro  Asn Leu Leu 
    3110                 3115                 3120             


Glu Tyr  Gly Asn Ile Thr Ala  Leu Thr Asn Leu Trp  Tyr Thr Gly 
    3125                 3130                 3135             


Gln Ile  Thr Asn Phe Glu Tyr  Leu Thr His Leu Asn  Lys His Ala 
    3140                 3145                 3150             


Gly Arg  Ser Phe Asn Asp Leu  Met Gln Tyr Pro Val  Phe Pro Phe 
    3155                 3160                 3165             


Ile Leu  Ala Asp Tyr Val Ser  Glu Thr Leu Asp Leu  Asn Asp Leu 
    3170                 3175                 3180             


Leu Ile  Tyr Arg Asn Leu Ser  Lys Pro Ile Ala Val  Gln Tyr Lys 
    3185                 3190                 3195             


Glu Lys  Glu Asp Arg Tyr Val  Asp Thr Tyr Lys Tyr  Leu Glu Glu 
    3200                 3205                 3210             


Glu Tyr  Arg Lys Gly Ala Arg  Glu Asp Asp Pro Met  Pro Pro Val 
    3215                 3220                 3225             


Gln Pro  Tyr His Tyr Gly Ser  His Tyr Ser Asn Ser  Gly Thr Val 
    3230                 3235                 3240             


Leu His  Phe Leu Val Arg Met  Pro Pro Phe Thr Lys  Met Phe Leu 
    3245                 3250                 3255             


Ala Tyr  Gln Asp Gln Ser Phe  Asp Ile Pro Asp Arg  Thr Phe His 
    3260                 3265                 3270             


Ser Thr  Asn Thr Thr Trp Arg  Leu Ser Ser Phe Glu  Ser Met Thr 
    3275                 3280                 3285             


Asp Val  Lys Glu Leu Ile Pro  Glu Phe Phe Tyr Leu  Pro Glu Phe 
    3290                 3295                 3300             


Leu Val  Asn Arg Glu Gly Phe  Asp Phe Gly Val Arg  Gln Asn Gly 
    3305                 3310                 3315             


Glu Arg  Val Asn His Val Asn  Leu Pro Pro Trp Ala  Arg Asn Asp 
    3320                 3325                 3330             


Pro Arg  Leu Phe Ile Leu Ile  His Arg Gln Ala Leu  Glu Ser Asp 
    3335                 3340                 3345             


Tyr Val  Ser Gln Asn Ile Cys  Gln Trp Ile Asp Leu  Val Phe Gly 
    3350                 3355                 3360             


Tyr Lys  Gln Lys Gly Lys Ala  Ser Val Gln Ala Ile  Asn Val Phe 
    3365                 3370                 3375             


His Pro  Ala Thr Tyr Phe Gly  Met Asp Val Ser Ala  Val Glu Asp 
    3380                 3385                 3390             


Pro Val  Gln Arg Arg Ala Leu  Glu Thr Met Ile Lys  Thr Tyr Gly 
    3395                 3400                 3405             


Gln Thr  Pro Arg Gln Leu Phe  His Met Ala His Val  Ser Arg Pro 
    3410                 3415                 3420             


Gly Ala  Lys Leu Asn Ile Glu  Gly Glu Leu Pro Ala  Ala Val Gly 
    3425                 3430                 3435             


Leu Leu  Val Gln Phe Ala Phe  Arg Glu Thr Arg Glu  Gln Val Lys 
    3440                 3445                 3450             


Glu Ile  Thr Tyr Pro Ser Pro  Leu Ser Trp Ile Lys  Gly Leu Lys 
    3455                 3460                 3465             


Trp Gly  Glu Tyr Val Gly Ser  Pro Ser Ala Pro Val  Pro Val Val 
    3470                 3475                 3480             


Cys Phe  Ser Gln Pro His Gly  Glu Arg Phe Gly Ser  Leu Gln Ala 
    3485                 3490                 3495             


Leu Pro  Thr Arg Ala Ile Cys  Gly Leu Ser Arg Asn  Phe Cys Leu 
    3500                 3505                 3510             


Leu Met  Thr Tyr Ser Lys Glu  Gln Gly Val Arg Ser  Met Asn Ser 
    3515                 3520                 3525             


Thr Asp  Ile Gln Trp Ser Ala  Ile Leu Ser Trp Gly  Tyr Ala Asp 
    3530                 3535                 3540             


Asn Ile  Leu Arg Leu Lys Ser  Lys Gln Ser Glu Pro  Pro Val Asn 
    3545                 3550                 3555             


Phe Ile  Gln Ser Ser Gln Gln  Tyr Gln Val Thr Ser  Cys Ala Trp 
    3560                 3565                 3570             


Val Pro  Asp Ser Cys Gln Leu  Phe Thr Gly Ser Lys  Cys Gly Val 
    3575                 3580                 3585             


Ile Thr  Ala Tyr Thr Asn Arg  Phe Thr Ser Ser Thr  Pro Ser Glu 
    3590                 3595                 3600             


Ile Glu  Met Glu Thr Gln Ile  His Leu Tyr Gly His  Thr Glu Glu 
    3605                 3610                 3615             


Ile Thr  Ser Leu Phe Val Cys  Lys Pro Tyr Ser Ile  Leu Ile Ser 
    3620                 3625                 3630             


Val Ser  Arg Asp Gly Thr Cys  Ile Ile Trp Asp Leu  Asn Arg Leu 
    3635                 3640                 3645             


Cys Tyr  Val Gln Ser Leu Ala  Gly His Lys Ser Pro  Val Thr Ala 
    3650                 3655                 3660             


Val Ser  Ala Ser Glu Thr Ser  Gly Asp Ile Ala Thr  Val Cys Asp 
    3665                 3670                 3675             


Ser Ala  Gly Gly Gly Ser Asp  Leu Arg Leu Trp Thr  Val Asn Gly 
    3680                 3685                 3690             


Asp Leu  Val Gly His Val His  Cys Arg Glu Ile Ile  Cys Ser Val 
    3695                 3700                 3705             


Ala Phe  Ser Asn Gln Pro Glu  Gly Val Ser Ile Asn  Val Ile Ala 
    3710                 3715                 3720             


Gly Gly  Leu Glu Asn Gly Ile  Val Arg Leu Trp Ser  Thr Trp Asp 
    3725                 3730                 3735             


Leu Lys  Pro Val Arg Glu Ile  Thr Phe Pro Lys Ser  Asn Lys Pro 
    3740                 3745                 3750             


Ile Ile  Ser Leu Thr Phe Ser  Cys Asp Gly His His  Leu Tyr Thr 
    3755                 3760                 3765             


Ala Asn  Ser Asp Gly Thr Val  Ile Ala Trp Cys Arg  Lys Asp Gln 
    3770                 3775                 3780             


Gln Arg  Leu Lys Gln Pro Met  Phe Tyr Ser Phe Leu  Ser Ser Tyr 
    3785                 3790                 3795             


Ala Ala  Gly 
    3800     


<210>  525
<211>  737
<212>  DNA
<213>  Homo sapiens

<400>  525
cctcctggtc tcagtatggc gctgtcctgg gttcttacag tcctgagcct cctacctctg       60

ctggaagccc agatcccatt gtgtgccaac ctagtaccgg tgcccatcac caacgccacc      120

ctggaccaga tcactggcaa gtggttttat atcgcatcgg cctttcgaaa cgaggagtac      180

aataagtcgg ttcaggagat ccaagcaacc ttcttttact tcacccccaa caagacagag      240

gacacgatct ttctcagaga gtaccagacc cgacaggacc agtgcatcta taacaccacc      300

tacctgaatg tccagcggga aaatgggacc atctccagat acgtgggagg ccaagagcat      360

ttcgctcact tgctgatcct cagggacacc aagacctaca tgcttgcttt tgacgtgaac      420

gatgagaaga actgggggct gtctgtctat gctgacaagc cagagacgac caaggagcaa      480

ctgggagagt tctacgaagc tctcgactgc ttgcgcattc ccaagtcaga tgtcgtgtac      540

accgattgga aaaaggataa gtgtgagcca ctggagaagc agcacgagaa ggagaggaaa      600

caggaggagg gggaatccta gcaggacaca gccttggatc aggacagaga cttgggggcc      660

atcctgcccc tccaacccga catgtgtacc tcagcttttt ccctcacttg catcaataaa      720

gcttctgtgt ttggaac                                                     737


<210>  526
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Gln Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly 
            100                 105                 110         


Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr 
        115                 120                 125             


Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  527
<211>  3030
<212>  DNA
<213>  Homo sapiens

<400>  527
atgtctgggg tgtccgagcc cctgagtcga gtaaagttgg gcacgttacg ccggcctgaa       60

ggccctgcag agcccatggt ggtggtacca gtagatgtgg aaaaggagga cgtgcgtatc      120

ctcaaggtct gcttctatag caacagcttc aatcctggga aaaacttcaa actggtcaaa      180

tgcactgtcc agacggagat ccgggagatc atcacctcca tcctgctgag cgggcggatc      240

gggcccaaca tccggttggc tgagtgctat gggctgaggc tgaagcacat gaagtccgat      300

gagatccact ggctgcaccc acagatgacg gtgggtgagg tgcaggacaa gtatgagtgt      360

ctgcacgtgg aagccgagtg gaggtatgac cttcaaatcc gctacttgcc agaagacttc      420

atggagagcc tgaaggagga caggaccacg ctgctctatt tttaccaaca gctccggaac      480

gactacatgc agcgctacgc cagcaaggtc agcgagggca tggccctgca gctgggctgc      540

ctggagctca ggcggttctt caaggatatg ccccacaatg cacttgacaa gaagtccaac      600

ttcgagctcc tagaaaagga agtggggctg gacttgtttt tcccaaagca gatgcaggag      660

aacttaaagc ccaaacagtt ccggaagatg atccagcaga ccttccagca gtacgcctcg      720

ctcagggagg aggagtgcgt catgaagttc ttcaacactc tcgccggctt cgccaacatc      780

gaccaggaga cctaccgctg tgaactcatt caaggatgga acattactgt ggacctggtc      840

attggcccta aagggatccg ccagctgact agtcaggacg caaagcccac ctgcctggcc      900

gagttcaagc agatcaggtc catcaggtgc ctcccgctgg aggagggcca ggcagtactt      960

cagctgggca ttgaaggtgc cccccaggcc ttgtccatca aaacctcatc cctagcagag     1020

gctgagaaca tggctgacct catagacggc tactgccggc tgcagggtga gcaccaaggc     1080

tctctcatca tccatcctag gaaagatggt gagaagcgga acagcctgcc ccagatcccc     1140

atgctaaacc tggaggcccg gcggtcccac ctctcagaga gctgcagcat agagtcagac     1200

atctacgcag agattcccga cgaaaccctg cgaaggcccg gaggtccaca gtatggcatt     1260

gcccgtgaag atgtggtcct gaatcgtatt cttggggaag gcttttttgg ggaggtctat     1320

gaaggtgtct acacaaatca caaaggggag aaaatcaatg tagctgtcaa gacctgcaag     1380

aaagactgca ctctggacaa caaggagaag ttcatgagcg aggcagtgat catgaagaac     1440

ctcgaccacc cgcacatcgt gaagctgatc ggcatcattg aagaggagcc cacctggatc     1500

atcatggaat tgtatcccta tggggagctg ggccactacc tggagcggaa caagaactcc     1560

ctgaaggtgc tcaccctcgt gctgtactca ctgcagatat gcaaagccat ggcctacctg     1620

gagagcatca actgcgtgca cagggacatt gctgtccgga acatcctggt ggcctcccct     1680

gagtgtgtga agctggggga ctttggtctt tcccggtaca ttgaggacga ggactattac     1740

aaagcctctg tgactcgtct ccccatcaaa tggatgtccc cagagtccat taacttccga     1800

cgcttcacga cagccagtga cgtctggatg ttcgccgtgt gcatgtggga gatcctgagc     1860

tttgggaagc agcccttctt ctggctggag aacaaggatg tcatcggggt gctggagaaa     1920

ggagaccggc tgcccaagcc tgatctctgt ccaccggtcc tttataccct catgacccgc     1980

tgctgggact acgaccccag tgaccggccc cgcttcaccg agctggtgtg cagcctcagt     2040

gacgtttatc agatggagaa ggacattgcc atggagcaag agaggaatgc tcgctaccga     2100

acccccaaaa tcttggagcc cacagccttc caggaacccc cacccaagcc cagccgacct     2160

aagtacagac cccctccgca aaccaacctc ctggctccaa agctgcagtt ccaggttcct     2220

gagggtctgt gtgccagctc tcctacgctc accagcccta tggagtatcc atctcccgtt     2280

aactcactgc acaccccacc tctccaccgg cacaatgtct tcaaacgcca cagcatgcgg     2340

gaggaggact tcatccaacc cagcagccga gaagaggccc agcagctgtg ggaggctgaa     2400

aaggtcaaaa tgcggcaaat cctggacaaa cagcagaagc agatggtgga ggactaccag     2460

tggctcaggc aggaggagaa gtccctggac cccatggttt atatgaatga taagtcccca     2520

ttgacgccag agaaggaggt cggctacctg gagttcacag ggcccccaca gaagcccccg     2580

aggctgggcg cacagtccat ccagcccaca gctaacctgg accggactga tgacctggtg     2640

tacctcaatg tcatggagct ggtgcgggcc gtgctggagc tcaagaatga gctctgtcag     2700

ctgccccccg agggctacgt ggtggtggtg aagaatgtgg ggctgaccct gcggaagctc     2760

atcgggagcg tggatgatct cctgccttcc ttgccgtcat cttcacggac agagatcgag     2820

ggcacccaga aactgctcaa caaagacctg gcagagctca tcaacaagat gcggctggca     2880

cagcagaacg ccgtgacctc cctaagtgag gagtgcaaga ggcagatgct gacggcttca     2940

cacaccctgg ctgtggacgc caagaacctg ctcgacgctg tggaccaggc caaggttctg     3000

gccaatctgg cccacccacc tgcagagtga                                      3030


<210>  528
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu 
1               5                   10                  15      


Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp 
            20                  25                  30          


Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn 
        35                  40                  45              


Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln 
    50                  55                  60                  


Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His 
                85                  90                  95      


Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly 
            100                 105                 110         


Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg 
        115                 120                 125             


Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu 
    130                 135                 140                 


Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn 
145                 150                 155                 160 


Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu 
                165                 170                 175     


Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His 
            180                 185                 190         


Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val 
        195                 200                 205             


Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro 
    210                 215                 220                 


Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser 
225                 230                 235                 240 


Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly 
                245                 250                 255     


Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly 
            260                 265                 270         


Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln 
        275                 280                 285             


Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln 
    290                 295                 300                 


Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu 
305                 310                 315                 320 


Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser 
                325                 330                 335     


Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys 
            340                 345                 350         


Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys 
        355                 360                 365             


Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu 
    370                 375                 380                 


Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp 
385                 390                 395                 400 


Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro 
                405                 410                 415     


Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly 
            420                 425                 430         


Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys 
        435                 440                 445             


Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr 
    450                 455                 460                 


Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn 
465                 470                 475                 480 


Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu 
                485                 490                 495     


Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His 
            500                 505                 510         


Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu 
        515                 520                 525             


Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn 
    530                 535                 540                 


Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro 
545                 550                 555                 560 


Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp 
                565                 570                 575     


Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met 
            580                 585                 590         


Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val 
        595                 600                 605             


Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln 
    610                 615                 620                 


Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys 
625                 630                 635                 640 


Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr 
                645                 650                 655     


Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe 
            660                 665                 670         


Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp 
        675                 680                 685             


Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile 
    690                 695                 700                 


Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro 
705                 710                 715                 720 


Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln 
                725                 730                 735     


Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser 
            740                 745                 750         


Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu 
        755                 760                 765             


His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe 
    770                 775                 780                 


Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu 
785                 790                 795                 800 


Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val 
                805                 810                 815     


Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met 
            820                 825                 830         


Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly 
        835                 840                 845             


Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala 
    850                 855                 860                 


Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val 
865                 870                 875                 880 


Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn 
                885                 890                 895     


Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn 
            900                 905                 910         


Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu 
        915                 920                 925             


Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys 
    930                 935                 940                 


Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala 
945                 950                 955                 960 


Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met 
                965                 970                 975     


Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp 
            980                 985                 990         


Ala Val Asp Gln Ala Lys Val Leu  Ala Asn Leu Ala His  Pro Pro Ala 
        995                 1000                 1005             


Glu 
    


<210>  529
<211>  7121
<212>  DNA
<213>  Homo sapiens

<400>  529
atgacaactg gcttgtctga tcagcaggtg gtctgtgacc ttgatcacag ggcagtggaa       60

gccctattgc aggcagttag gaagaggatg gcaggggcct cgcccgcggt cccccatgag      120

cgcgcccggc tgaccggcgg ggcggccgcg gtggagcccg cgtgccgcgg gggcggcggg      180

gccatggcct cgctggacct gccgtaccgc tgcccccgct gcggggagca caagcgcttc      240

cggagcctgt cgtcgctgcg cgcgcacctg gagtacagcc acacctacga gacgctctac      300

atcctctcca agaccaacag catctgcgac ggcgccgccg ccgccgcggc cgccgccgcc      360

gctgcctcgg ggttcccgct ggctcccgag cccgccgccc tgctggccgt gcccggcgcc      420

cggcgagagg tcttcgagag cacttccttc cagggcaagg agcaggcggc cgggccgtcg      480

cccgcggcgc cgcacctgct gcaccaccac catcaccacg ctcccctcgc ccacttcccc      540

ggcgacctgg tgcccgctag cctgccctgt gaggagttgg ccgagccggg ccttgtgccc      600

gccgcagcag cgcgctatgc gctgcgcgag atcgagatcc cgctggggga gctgttcgcc      660

cgcaagtccg tggcgtcctc ggcgtgctcg acgccgccgc ctggccccgg ccccggccct      720

tgccccgggc ctgcctccgc ttcgcccgcg tccccctcac ccgctgatgt ggcctacgaa      780

gagggcctgg cgcgcctcaa gatccgcgcg ctggagaagc tggaggtgga ccggcggctg      840

gagcggctga gcgaggaggt ggagcagaag atcgcgggcc aggtgggccg gctgcaggcc      900

gagctggagc gcaaggcggc cgaactggag actgcgcggc aggagagtgc gaggctcggg      960

cgcgagaagg aggagctgga ggagcgcgcg tctgagctct cccgccaggt ggacgtgagc     1020

gtagagctgc tggcctcact caagcaggac ctggtgcaca aggaacagga gctgagccgc     1080

aagcagcagg aggtggtgca gatcgaccag ttcctgaagg agacggcggc gcgggaggcc     1140

agcgccaagc tgcggctgca gcagttcatt gaggagctcc ttgagcgggc tgaccgtgcc     1200

gagcggcagc tgcaggtcat cagcagcagc tgtggcagca cgcccagcgc cagcctgggc     1260

cgtggaggtg ggggcggtgg tgctggaccc aatgcccggg gcccaggcag aatgcgagaa     1320

caccacgtgg gcccggccgt gcctaacaca tatgcagtgt cacggcatgg ctcctctccg     1380

agcacagggg cctccagccg tgtgccagcc gcatcccaga gctcaggctg ctatgacagt     1440

gacagtctgg agctgcccag gccagaggag ggggcccctg aggacagtgg ccctgggggc     1500

ttgggcacac gggcccaggc tgccaacggg ggctcagagc ggtcccagcc ccctcgcagc     1560

tcaggcctgc ggcgccaggc catccagaac tggcagcgca gaccccgccg acacagcact     1620

gagggggaag agggtgatgt ctccgacgtt ggctcccgaa ccactgagtc agaggctgag     1680

ggcccgttgg atgcgccccg ccccgggcct gctatggctg ggccattgag cagctgccgg     1740

ctctcagccc gccccgaggg aggcagtggg cggggtcggc gagcagagag ggtcagcccc     1800

tcacgctcca atgaggtcat cagcccagag atcctgaaga tgcgagctgc cctcttctgc     1860

atcttcacct acctggacac gcgcacactg ctgcatgctg ccgaggtctg ccgggactgg     1920

cgcttcgtgg cccgccaccc cgcagtctgg acaagggtgc tgcttgagaa tgcccgtgtc     1980

tgctccaagt tcctggcaat gctggctcag tggtgcaccc aggcccactc tctgacgctg     2040

cagaacttga agccccggca gcggggaaag aaggagagca aggaggagta tgcccggagc     2100

acccggggct gcctggaagc tgggctggag tccctgctga aggcagctgg ggggaacctg     2160

ctgatcctgc gcatctccca ctgtccaaac atcctcaccg accgctcgct ctggctggcc     2220

agctgctact gccgtgccct gcaggctgtc acgtacagga gtgccacaga ccccgtgggc     2280

catgaggtca tttgggccct gggcgcaggc tgcagagaga tcgtctccct ccaagtggca     2340

ccacttcacc cctgccagca gcccacacgc ttcagtaacc gctgcctgca gatgattggt     2400

cgctgttggc cccacctgcg ggccctgggg gtcgggggtg ccggctgtgg ggtgcagggc     2460

ctggcatcac tcgcgagaaa ctgcatgcgg ctgcaggtcc tggagcttga ccacgtgtca     2520

gagatcaccc aggaggtggc agcagaggtc tgccgggaag gcctgaaggg actggagatg     2580

ctggtgctca cggcgactcc cgtcacccct aaggccctac tgcacttcaa cagcatctgc     2640

cggaacctca agtccattgt ggtccagatt gggattgcgg attatttcaa agagcccagc     2700

agccctgagg cccagaagct gtttgaggac atggtgacaa aactccaggc tctgcgacgg     2760

aggcccggct tctctaagat tctgcacatc aaggtggaag gcggctgcta acccgggtag     2820

ggggcggcag ggcccctgcc agccccacac cagggcactc tctttggacc tcagagggac     2880

cctggtttgg actagacctt tggaggccga gtgttatccc tggcttctgg agggggactg     2940

tcaagtctcc tgtcctcctc ctggagcagc agagcaacag gcctgaccca gggcactgcc     3000

tccccagtac aggggcttgg acagaagctg ccctccgacc cccaccctac cccggctgga     3060

gtagcctctg gcacagccag tgaggagctg tcaccaccag cgcctggtgt catcacctgg     3120

aggatctgca ataaccaccc agtggctcct cagctgttct ggctggcctc tccttcctga     3180

ggcccagcct cctggtcagg agcatctggg gccccaagcc aatgggggct ccacaaggca     3240

gctcagactt ggcaaggagg gctcttctcc tcaaccttgc tgcagccttc tgggggcacc     3300

ccttcagaca gcctgcccag gctgtggatc cacatttcct gggggtacca cagccagacc     3360

taggggcctg ggcacgtggt cagccaaaag ctgggggcag cagtacagtg gggtagtggg     3420

ggtgggtttg gaaaggaaac agtcacccag aacttctccc caggatgaga ccacccttcc     3480

aaggtggggg attgccaggg ggagaaaact tatttattgc tgtaagacag gacccctcct     3540

cccaacctca taccccaccg cacaccagag ctaaattcaa agctgaaagg cgcacgtttc     3600

tatacctaca ttcattcctg agggaccctc cagagggtca aggtcccagc cccaggcagc     3660

cctgtcacag tgagaagtag ttcctgtcct taaggaattt ccttctaatc caggtgcttg     3720

ggcaggaacc cgatggcctt cgggtcacca aggctgtctg ggagggaggc acagggccgc     3780

cctctgtgct gaggccgtgg aggaagccag gaggagggtg gcttgctttg cttccttgtc     3840

taattagctt gcttgaagat gtggccttgg cagggagcca gacccatggg gccaaggaag     3900

aggaagagca tcctcaatag actcactccc ccttccttgg tctccacggg ccccgtggac     3960

tgagggctgc attggggtct tctgcctagg ggaagtgctg gacctgagct ggagccactt     4020

ggcttagaag ccacaggatt cacttttcac tggcctttgc agtccccaaa ggatcaggtc     4080

tcagaaccaa ggctccaaag gctgaggtct ccccagttcc tcctctcaga actcccacag     4140

tagctcagag gccgggggtc ctgccaactt tcatttggaa agttctttcg aacatctaaa     4200

ctagatctat cttagggttt ctttctctcc tagataggat cagctcccag ccctagccat     4260

taggctgctg gtcctggcgg gggatggggt cccctcgtta cccagtcctt cccagggacc     4320

caacttccta acacaacctg gcttggacat gaagaccctc ccccaggtta ccttgtaaag     4380

agtcctccag agctgggatc ccatgggcgc agcagcacac ccagctccca tggcgtcact     4440

ccctagctct gtcccagctt ttgctatcat tgctgacttt tcctcctgtg gctcattctg     4500

tccctgccct ttgaaaacct aaaataccaa gggtgtcatg ctggcaactc cctgcccagt     4560

cctgcacaaa gccttggctg tgtgtggcac cccttgcctc ctaccccaga gcagctggct     4620

ccattggctt ctccctgcac cagccctgtc ctcaggggtc aggaaaaagc agcacagctt     4680

tctttcctct cctccagagg cctggaaggg aggtggaggt ccagtaaggg cctggctgcc     4740

ttggatttct tggtcctgcc ttgccaactg caccctgtag ctcctgctcc ctgtgacccc     4800

agaaccagag gtgctgcctt ccctgtctcc tagacaaagc acaaagggat gccctgcttg     4860

gcttgagcct gcccaactga aggattttct ctgccccagg gaccttccat ccctgaatac     4920

aaggctctag gcaacttctc tctgggtggt acacactaga atgcctggca ttagccctag     4980

aaaggaggtt ggggtgtatg ggtagtgagc tagggtggga gaaaggtggt gctgaaagga     5040

cagatgctag ttgtagtttc actcactcat tcattcatta gtgcaacagt actgagcacc     5100

acctgcacta gaggcagagg ggtgaacaag atacccttct gcctgggggg acgtccactt     5160

cccatgggtt tggctatttc caggaaagcc cctcagtcct ccaccctgtt ctggctgtgt     5220

gtgaaggatg tgtgtgagca ggcccaatcc tttgcagcaa gaatgagagg tcagagtatt     5280

ccattgcaca cgcaccctgg ggctgacaga cttgtgcccc ctagccttca tgcatgccca     5340

agcactggca gctttgcagc ccctgcccca ccagcccctt gacgctcttc ttttgttctc     5400

tcctcgggga tgagctctgc tgctgagtag ggagcttttg cttgctggga ggctctatgc     5460

atggattttt ttggtgacca tacagctagg gctgaggatg ggaacaggga cagagggcct     5520

ggctatccct agaagcactt catccatctt tacccaccca aacgggatcc cttcacatct     5580

catacccagt aagatgcaag aaaggaatat ctgagagcaa gcagccctgc tccaggggcc     5640

ccaggtatgt gtagaggccc agtgggggtg gccacttggt gtttctacca ccccctgcca     5700

tccagtctgg ccccagtacc tacctgggag gttggtgtac ttggcttaag tacttcatgc     5760

tttattcagg ctgcttcccc acagcaccgg caggaaatga aggtgcactt atatgcatcc     5820

ctgcaggaat aaagagtggg tggcctgccc agcccagcac cacagccttt ccccagccag     5880

gagagaccac ctaaggatca aggcagctcc tgttttcttg gttctgtgac actcgagtct     5940

gagccagccc ctcaggaatt gcctcaaaag agaaaaacaa aaaaaagtcc tccttcccaa     6000

ggcctgctac tccaaggttt ggctccatcc cttgcctttg ggtcctgcct atttccccac     6060

tcctggtctc ttatctttgg ggccaccagt ggggagtcac ccgggcccca atccctctaa     6120

ggcgctaagt tgaaggaggc cttcccagag tgactattgg tgccaaagtc ccagttcctg     6180

ttggacttgg ggtaaaaaca ggagatggtg agtgggtgta aggcccaaat gcccagagaa     6240

gttaactcga acccatggga cctgtcccag cctgtcagtc cctgatgagt gtaacttcct     6300

tcccctgggg gcctggccct tctctccaac ccagtggcca tgctttctca cccagccttg     6360

tgcccggcct gcatttctgt atatattgct gtgtattgtg tgtatgtatg tattcctgga     6420

caagtgtgtt catctgcagc ccttgcctga ggataaggtt taggattggg taaagatcag     6480

aataccaggg ccagctaagg caacgactcc ctccccaaac ccttgggacc tcagccagtc     6540

ccaaggctgc cctgacaatc aggcaggctc cccaccgtga ggccaagcct cctctgccac     6600

tgccagcatg gcccaaggga ggcttggcct tgggcttgcc agcctcagct ctgccctgac     6660

aagggtcttg tatccagggc agaggcctga ggtgacccag gcttgctttg tggctgatgc     6720

cagcaggctt ggttctagtg ggcaccactg gtgggcaacc tccataactg gcccttaggc     6780

cctaccttcc tacacagcta ggctataatg ggcctgagtg agagggtagc ttccccagcc     6840

ccaagcacag gcagaggggt ggagagcaat ttttggtttt atttttgttt ctgaagtggt     6900

gcctgtacct ccagccccca gggggccttc cctggccaca cttctctgcc ccacccaggc     6960

atcgccatcc cagcactttg ctccatgtca cccgtaagat gccctttgct gaatgtacct     7020

gagtgtatgt atttaaaagg actcacatgg gcatcagaga atttatggct ctgtatccaa     7080

taaaaaagat ggtgaaactg gtctatctgc cccagagagg t                         7121


<210>  530
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Thr Thr Gly Leu Ser Asp Gln Gln Val Val Cys Asp Leu Asp His 
1               5                   10                  15      


Arg Ala Val Glu Ala Leu Leu Gln Ala Val Arg Lys Arg Met Ala Gly 
            20                  25                  30          


Ala Ser Pro Ala Val Pro His Glu Arg Ala Arg Leu Thr Gly Gly Ala 
        35                  40                  45              


Ala Ala Val Glu Pro Ala Cys Arg Gly Gly Gly Gly Ala Met Ala Ser 
    50                  55                  60                  


Leu Asp Leu Pro Tyr Arg Cys Pro Arg Cys Gly Glu His Lys Arg Phe 
65                  70                  75                  80  


Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu Tyr Ser His Thr Tyr 
                85                  90                  95      


Glu Thr Leu Tyr Ile Leu Ser Lys Thr Asn Ser Ile Cys Asp Gly Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Phe Pro Leu Ala 
        115                 120                 125             


Pro Glu Pro Ala Ala Leu Leu Ala Val Pro Gly Ala Arg Arg Glu Val 
    130                 135                 140                 


Phe Glu Ser Thr Ser Phe Gln Gly Lys Glu Gln Ala Ala Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Ala Pro His Leu Leu His His His His His His Ala Pro Leu 
                165                 170                 175     


Ala His Phe Pro Gly Asp Leu Val Pro Ala Ser Leu Pro Cys Glu Glu 
            180                 185                 190         


Leu Ala Glu Pro Gly Leu Val Pro Ala Ala Ala Ala Arg Tyr Ala Leu 
        195                 200                 205             


Arg Glu Ile Glu Ile Pro Leu Gly Glu Leu Phe Ala Arg Lys Ser Val 
    210                 215                 220                 


Ala Ser Ser Ala Cys Ser Thr Pro Pro Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Cys Pro Gly Pro Ala Ser Ala Ser Pro Ala Ser Pro Ser Pro Ala Asp 
                245                 250                 255     


Val Ala Tyr Glu Glu Gly Leu Ala Arg Leu Lys Ile Arg Ala Leu Glu 
            260                 265                 270         


Lys Leu Glu Val Asp Arg Arg Leu Glu Arg Leu Ser Glu Glu Val Glu 
        275                 280                 285             


Gln Lys Ile Ala Gly Gln Val Gly Arg Leu Gln Ala Glu Leu Glu Arg 
    290                 295                 300                 


Lys Ala Ala Glu Leu Glu Thr Ala Arg Gln Glu Ser Ala Arg Leu Gly 
305                 310                 315                 320 


Arg Glu Lys Glu Glu Leu Glu Glu Arg Ala Ser Glu Leu Ser Arg Gln 
                325                 330                 335     


Val Asp Val Ser Val Glu Leu Leu Ala Ser Leu Lys Gln Asp Leu Val 
            340                 345                 350         


His Lys Glu Gln Glu Leu Ser Arg Lys Gln Gln Glu Val Val Gln Ile 
        355                 360                 365             


Asp Gln Phe Leu Lys Glu Thr Ala Ala Arg Glu Ala Ser Ala Lys Leu 
    370                 375                 380                 


Arg Leu Gln Gln Phe Ile Glu Glu Leu Leu Glu Arg Ala Asp Arg Ala 
385                 390                 395                 400 


Glu Arg Gln Leu Gln Val Ile Ser Ser Ser Cys Gly Ser Thr Pro Ser 
                405                 410                 415     


Ala Ser Leu Gly Arg Gly Gly Gly Gly Gly Gly Ala Gly Pro Asn Ala 
            420                 425                 430         


Arg Gly Pro Gly Arg Met Arg Glu His His Val Gly Pro Ala Val Pro 
        435                 440                 445             


Asn Thr Tyr Ala Val Ser Arg His Gly Ser Ser Pro Ser Thr Gly Ala 
    450                 455                 460                 


Ser Ser Arg Val Pro Ala Ala Ser Gln Ser Ser Gly Cys Tyr Asp Ser 
465                 470                 475                 480 


Asp Ser Leu Glu Leu Pro Arg Pro Glu Glu Gly Ala Pro Glu Asp Ser 
                485                 490                 495     


Gly Pro Gly Gly Leu Gly Thr Arg Ala Gln Ala Ala Asn Gly Gly Ser 
            500                 505                 510         


Glu Arg Ser Gln Pro Pro Arg Ser Ser Gly Leu Arg Arg Gln Ala Ile 
        515                 520                 525             


Gln Asn Trp Gln Arg Arg Pro Arg Arg His Ser Thr Glu Gly Glu Glu 
    530                 535                 540                 


Gly Asp Val Ser Asp Val Gly Ser Arg Thr Thr Glu Ser Glu Ala Glu 
545                 550                 555                 560 


Gly Pro Leu Asp Ala Pro Arg Pro Gly Pro Ala Met Ala Gly Pro Leu 
                565                 570                 575     


Ser Ser Cys Arg Leu Ser Ala Arg Pro Glu Gly Gly Ser Gly Arg Gly 
            580                 585                 590         


Arg Arg Ala Glu Arg Val Ser Pro Ser Arg Ser Asn Glu Val Ile Ser 
        595                 600                 605             


Pro Glu Ile Leu Lys Met Arg Ala Ala Leu Phe Cys Ile Phe Thr Tyr 
    610                 615                 620                 


Leu Asp Thr Arg Thr Leu Leu His Ala Ala Glu Val Cys Arg Asp Trp 
625                 630                 635                 640 


Arg Phe Val Ala Arg His Pro Ala Val Trp Thr Arg Val Leu Leu Glu 
                645                 650                 655     


Asn Ala Arg Val Cys Ser Lys Phe Leu Ala Met Leu Ala Gln Trp Cys 
            660                 665                 670         


Thr Gln Ala His Ser Leu Thr Leu Gln Asn Leu Lys Pro Arg Gln Arg 
        675                 680                 685             


Gly Lys Lys Glu Ser Lys Glu Glu Tyr Ala Arg Ser Thr Arg Gly Cys 
    690                 695                 700                 


Leu Glu Ala Gly Leu Glu Ser Leu Leu Lys Ala Ala Gly Gly Asn Leu 
705                 710                 715                 720 


Leu Ile Leu Arg Ile Ser His Cys Pro Asn Ile Leu Thr Asp Arg Ser 
                725                 730                 735     


Leu Trp Leu Ala Ser Cys Tyr Cys Arg Ala Leu Gln Ala Val Thr Tyr 
            740                 745                 750         


Arg Ser Ala Thr Asp Pro Val Gly His Glu Val Ile Trp Ala Leu Gly 
        755                 760                 765             


Ala Gly Cys Arg Glu Ile Val Ser Leu Gln Val Ala Pro Leu His Pro 
    770                 775                 780                 


Cys Gln Gln Pro Thr Arg Phe Ser Asn Arg Cys Leu Gln Met Ile Gly 
785                 790                 795                 800 


Arg Cys Trp Pro His Leu Arg Ala Leu Gly Val Gly Gly Ala Gly Cys 
                805                 810                 815     


Gly Val Gln Gly Leu Ala Ser Leu Ala Arg Asn Cys Met Arg Leu Gln 
            820                 825                 830         


Val Leu Glu Leu Asp His Val Ser Glu Ile Thr Gln Glu Val Ala Ala 
        835                 840                 845             


Glu Val Cys Arg Glu Gly Leu Lys Gly Leu Glu Met Leu Val Leu Thr 
    850                 855                 860                 


Ala Thr Pro Val Thr Pro Lys Ala Leu Leu His Phe Asn Ser Ile Cys 
865                 870                 875                 880 


Arg Asn Leu Lys Ser Ile Val Val Gln Ile Gly Ile Ala Asp Tyr Phe 
                885                 890                 895     


Lys Glu Pro Ser Ser Pro Glu Ala Gln Lys Leu Phe Glu Asp Met Val 
            900                 905                 910         


Thr Lys Leu Gln Ala Leu Arg Arg Arg Pro Gly Phe Ser Lys Ile Leu 
        915                 920                 925             


His Ile Lys Val Glu Gly Gly Cys 
    930                 935     


<210>  531
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  531
atggctctaa agaagtcatc accctcactg gattctggtg atagtgactc tgaggagttg       60

ccaacatttg cctttctgaa gaaggaacca tcttcaacaa agaggagaca gcctgaaagg      120

gaagagaaga ttgtagtggt tgacatctca gattgtgaag cctcctgtcc tccagcacca      180

gagttatttt caccacctgt cccagaaata gctgaaactg tcacacaaac acagccagtc      240

aggttgctaa gcagtgaaag tgaagatgaa gaagaattta ttcctctggc tcaaaggctt      300

acatgtaagt ttctgaccca caagcaactg agccctgagg actctagctc cccagttaaa      360

agtgttttgg atcatcaaaa taatgaaggt gcatcatgtg actggaaaaa gccctttcca      420

aagatccctg aagttcccct ccatgatacc ccagagagga gtgcagcaga taacaaggac      480

ctgatcttag atccatgctg tcagcttcca gcctacctgt ctacctgccc tggccagagc      540

agcagcttgg cagtaaccaa aacaaattct gacatccttc caccccagaa gaaaaccaag      600

ccgagtcaga aggtccaggg aagaggctca cacggatgcc ggcagcagag acaagcaagg      660

cagaaggaaa gcaccctgag aagacaggaa agaaagaatg cagcactggt taccaggatg      720

aaagcccaga ggccagagga atgcttaaaa cacatcattg tagtgctgga tccagtgctc      780

ttacagatgg aaggtggggg ccagctccta ggagcactgc agaccatgga gtgccgctgt      840

gtgattgagg cgcaggctgt gccttgcagt gtcacttgga ggagaagggc tgggccgtct      900

gaggacagag aggactgggt ggaggagcca acagtactgg tgttgctccg ggcagaggca      960

tttgtgtcca tgatcgacaa tggaaagcag ggaagcctgg acagcactat gaaagggaag     1020

gaaacgcttc agggctttgt aactgacatc acagcaaaga cagcagggaa agctctgtca     1080

ctggtgattg tggatcagga gaaatgcttc agtgctcaga atcctccaag aagagggaaa     1140

cagggagcaa ataaacagac caagaagcag cagcagagac aaccagaggc cagcataggg     1200

tccatggtat ccagggtaga cgctgaagag gcattggtgg atctgcagct acacacagaa     1260

gcccaggctc aaattgtgca gagctggaaa gagctggccg acttcacatg cgcattcaca     1320

aaggctgtgg ctgaggcgcc cttcaagaag ctccgagatg aaactacctt ctccttctgt     1380

ctggagagtg actgggctgg aggggtgaag gtggaccttg ctggcagggg actcgcacta     1440

gtctggagga gacagattca gcagctgaac cgagtcagcc tggaaatggc cagtgcagtt     1500

gtgaatgcct atccctcccc acagctcctg gtacaggctt atcagcagtg tttttcggat     1560

aaagaacgcc agaatttgct cgcagacata caggtgcgcc gtggggaagg tgtgacatcc     1620

acttctcgcc gcattggacc agaactatcc aggcgtatct accttcagat gaccacttta     1680

cagccacatc tctctttaga tagtgctgac tga                                  1713


<210>  532
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 
1               5                   10                  15      


Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 
            20                  25                  30          


Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 
        35                  40                  45              


Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 
    50                  55                  60                  


Pro Pro Val Pro Glu Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 
65                  70                  75                  80  


Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 
                85                  90                  95      


Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 
            100                 105                 110         


Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 
        115                 120                 125             


Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 
    130                 135                 140                 


Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 
145                 150                 155                 160 


Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 
                165                 170                 175     


Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 
            180                 185                 190         


Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 
        195                 200                 205             


Gly Ser His Gly Cys Arg Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 
    210                 215                 220                 


Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 
225                 230                 235                 240 


Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 
                245                 250                 255     


Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 
            260                 265                 270         


Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 
        275                 280                 285             


Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 
    290                 295                 300                 


Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 
305                 310                 315                 320 


Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 
                325                 330                 335     


Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 
            340                 345                 350         


Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 
        355                 360                 365             


Cys Phe Ser Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn 
    370                 375                 380                 


Lys Gln Thr Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly 
385                 390                 395                 400 


Ser Met Val Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln 
                405                 410                 415     


Leu His Thr Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu 
            420                 425                 430         


Ala Asp Phe Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe 
        435                 440                 445             


Lys Lys Leu Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp 
    450                 455                 460                 


Trp Ala Gly Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu 
465                 470                 475                 480 


Val Trp Arg Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met 
                485                 490                 495     


Ala Ser Ala Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln 
            500                 505                 510         


Ala Tyr Gln Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala 
        515                 520                 525             


Asp Ile Gln Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg 
    530                 535                 540                 


Ile Gly Pro Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu 
545                 550                 555                 560 


Gln Pro His Leu Ser Leu Asp Ser Ala Asp 
                565                 570 


<210>  533
<211>  3774
<212>  DNA
<213>  Homo sapiens

<400>  533
atgatgtgtg aagtgatgcc cacgattaat gaggacaccc caatgagcca aagggggtcc       60

caaagcagtg gctcggactc agactcccat tttgagcagc tgatggtgaa tatgctagat      120

gaaagggatc gtcttctaga cacccttcgg gagacccagg aaagcctctc acttgcccag      180

caaagacttc aggatgtcat ctatgaccga gactcactcc agagacagct caattcagcc      240

ctgccacagg atatcgaatc cctaacagga gggctggctg gttctaaggg ggctgatcca      300

ccggaatttg ctgcactgac aaaagaatta aatgcctgca gggaacaact tctagaaaag      360

gaagaagaaa tctctgaact taaagctgaa agaaacaaca caagactatt actggagcat      420

ttggagtgcc ttgtgtcacg acatgaaaga tcactaagaa tgacggtggt aaaacggcaa      480

gcccagtctc cctcaggagt atccagtgaa gttgaagttc tcaaggcact gaaatctttg      540

tttgagcacc acaaggcctt ggatgaaaag gtaagggagc gactgagggt ttctttagaa      600

agagtctctg cactggaaga agaactagct gctgctaatc aggagattgt tgccttgcgt      660

gaacaaaatg ttcatataca aagaaaaatg gcatcaagcg agggatccac agagtcagaa      720

catcttgaag ggatggaacc tggacagaaa gtccatgaga agcgtttgtc caatggttct      780

atagactcaa ccgatgaaac tagtcaaata gttgaactac aagaattgct tgaaaagcaa      840

aactatgaaa tggcccagat gaaagaacgt ttagcagccc tttcttcccg agtgggagag      900

gtggaacagg aagcagagac agcaagaaag gatctcatta aaacagaaga aatgaacacc      960

aagtatcaaa gggacattag ggaggccatg gcacaaaagg aagatatgga agaaagaatt     1020

acaacccttg aaaagcgtta cctcagtgct cagagagaat ctacctccat acatgacatg     1080

aatgataaac tagaaaatga gttagcaaat aaagaagcta tcctacggca gatggaagag     1140

aaaaacagac agttacaaga acgtcttgag ctagctgaag aaaagttgca gcagaccatg     1200

agaaaggctg aaaccttgcc tgaagtagag gctgaactgg ctcagagaat tgcagcccta     1260

accaaggctg aagagacaca tggaaatatt gaagaacgta tgagacattt agagggtcaa     1320

cttgaagaga agaatcaaga acttcaaaga gctaggcaaa gagagaaaat gaatgaggag     1380

cataacaaga gattatcgga tacggttgat agacttctga ctgaatccaa tgaacgccta     1440

caactacact taaaggaaag aatggctgct ctagaagaaa agaatgtttt aattcaagaa     1500

tcagaaactt tcagaaagaa tcttgaagaa tctttacatg ataaggaaag cttagcagaa     1560

gaaattgaaa agctgagatc tgaacttgac caattgaaaa tgagaactgg ctctttaatt     1620

gaacccacaa taccaagaac tcatctagac acctcagctg agttgcggta ctcagtggga     1680

tccctagtgg acagccagtc tgattacaga acaactaaag taataagaag accaaggaga     1740

ggccgcatgg gtgtgcgaag agatgagcca aaggtgaaat ctcttgggga tcacgagtgg     1800

aatagaactc aacagattgg agtactaagc agccaccctt ttgaaagtga cactgaaatg     1860

tctgatattg atgatgatga cagagaaaca atttttagct caatggatct tctctctcca     1920

agtggtcatt ccgatgccca gacgctagcc atgatgcttc aggaacaatt ggatgccatc     1980

aacaaagaaa tcaggctaat tcaggaagaa aaagaatcta cagagttgcg tgctgaagaa     2040

attgaaaata gagtggctag tgtgagcctc gaaggcctga atttggcaat ggtccaccca     2100

ggtacctcca ttactgcctc tgttacagct tcatcgctgg ccagttcatc tccccccagt     2160

ggacactcaa ctccaaagct cacccctcga agccctgcca gggaaatgga tcggatggga     2220

gtcatgacac tgccaagtga tctgaggaaa catcggagaa agattgcagt tgtggaagaa     2280

gatggtcgag aggacaaagc aacaattaaa tgtgaaactt ctcctcctcc tacccctaga     2340

gccctcagaa tgactcacac tctcccttct tcctaccaca atgatgctcg aagtagttta     2400

tctgtctctc ttgagccaga aagcctcggg cttggtagtg ccaacagcag ccaagactct     2460

cttcacaaag cccccaagaa gaaaggaatc aagtcttcaa taggacgttt gtttggtaaa     2520

aaagaaaaag ctcgacttgg gcagctccga ggctttatgg agactgaagc tgcagctcag     2580

gagtccctgg ggttaggcaa actcggaact caagctgaga aggatcgaag actaaagaaa     2640

aagcatgaac ttcttgaaga agctcggaga aagggattac cttttgccca gtgggatggg     2700

ccaactgtgg tcgcatggct agagctttgg ttgggaatgc ctgcgtggta cgtggcagcc     2760

tgccgagcca acgtgaagag tggtgccatc atgtctgctt tatctgacac tgagatccag     2820

agagaaattg gaatcagcaa tccactgcat cgcttaaaac ttcgattagc aatccaggag     2880

atggtttccc taacaagtcc ttcagctcct ccaacatctc gaactccttc aggcaacgtt     2940

tgggtgactc atgaagaaat ggaaaatctt gcagctccag caaaaacgaa agaatctgag     3000

gaaggaagct gggcccagtg tccggttttt ctacagaccc tggcttatgg agatatgaat     3060

catgagtgga ttggaaatga atggcttccc agcttggggt tacctcagta cagaagttac     3120

tttatggaat gcttggtaga tgcaagaatg ttagatcacc taacaaaaaa agatctccgt     3180

gtccatttaa aaatggtgga tagtttccat cgaacaagtt tacaatatgg aattatgtgc     3240

ttaaagaggt tgaattatga cagaaaagaa ctagaaagaa gacgggaagc aagccaacat     3300

gaaataaaag acgtgttggt gtggagcaat gaccgagtta ttcgctggat acaagcaatt     3360

ggacttcgag aatatgcaaa taatatactt gagagcggtg tgcatggctc acttatagcc     3420

ctggatgaaa actttgacta cagcagctta gctttattat tacagattcc aacacagaac     3480

acccaggcaa ggcagattct tgaaagagaa tacaataacc tcttggccct gggaactgaa     3540

aggcgactgg atgaaagtga tgacaagaac ttcagacgtg gatcaacctg gagaaggcag     3600

tttcctcctc gtgaagtaca tggaatcagc atgatgcctg ggtcctcaga aacattacca     3660

gctggattta ggttaaccac aacctctggg cagtcaagaa aaatgacaac agatgttgct     3720

tcatcaagac tgcagaggtt agacaactcc actgttcgca catactcatg ttga           3774


<210>  534
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Met Cys Glu Val Met Pro Thr Ile Asn Glu Asp Thr Pro Met Ser 
1               5                   10                  15      


Gln Arg Gly Ser Gln Ser Ser Gly Ser Asp Ser Asp Ser His Phe Glu 
            20                  25                  30          


Gln Leu Met Val Asn Met Leu Asp Glu Arg Asp Arg Leu Leu Asp Thr 
        35                  40                  45              


Leu Arg Glu Thr Gln Glu Ser Leu Ser Leu Ala Gln Gln Arg Leu Gln 
    50                  55                  60                  


Asp Val Ile Tyr Asp Arg Asp Ser Leu Gln Arg Gln Leu Asn Ser Ala 
65                  70                  75                  80  


Leu Pro Gln Asp Ile Glu Ser Leu Thr Gly Gly Leu Ala Gly Ser Lys 
                85                  90                  95      


Gly Ala Asp Pro Pro Glu Phe Ala Ala Leu Thr Lys Glu Leu Asn Ala 
            100                 105                 110         


Cys Arg Glu Gln Leu Leu Glu Lys Glu Glu Glu Ile Ser Glu Leu Lys 
        115                 120                 125             


Ala Glu Arg Asn Asn Thr Arg Leu Leu Leu Glu His Leu Glu Cys Leu 
    130                 135                 140                 


Val Ser Arg His Glu Arg Ser Leu Arg Met Thr Val Val Lys Arg Gln 
145                 150                 155                 160 


Ala Gln Ser Pro Ser Gly Val Ser Ser Glu Val Glu Val Leu Lys Ala 
                165                 170                 175     


Leu Lys Ser Leu Phe Glu His His Lys Ala Leu Asp Glu Lys Val Arg 
            180                 185                 190         


Glu Arg Leu Arg Val Ser Leu Glu Arg Val Ser Ala Leu Glu Glu Glu 
        195                 200                 205             


Leu Ala Ala Ala Asn Gln Glu Ile Val Ala Leu Arg Glu Gln Asn Val 
    210                 215                 220                 


His Ile Gln Arg Lys Met Ala Ser Ser Glu Gly Ser Thr Glu Ser Glu 
225                 230                 235                 240 


His Leu Glu Gly Met Glu Pro Gly Gln Lys Val His Glu Lys Arg Leu 
                245                 250                 255     


Ser Asn Gly Ser Ile Asp Ser Thr Asp Glu Thr Ser Gln Ile Val Glu 
            260                 265                 270         


Leu Gln Glu Leu Leu Glu Lys Gln Asn Tyr Glu Met Ala Gln Met Lys 
        275                 280                 285             


Glu Arg Leu Ala Ala Leu Ser Ser Arg Val Gly Glu Val Glu Gln Glu 
    290                 295                 300                 


Ala Glu Thr Ala Arg Lys Asp Leu Ile Lys Thr Glu Glu Met Asn Thr 
305                 310                 315                 320 


Lys Tyr Gln Arg Asp Ile Arg Glu Ala Met Ala Gln Lys Glu Asp Met 
                325                 330                 335     


Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg 
            340                 345                 350         


Glu Ser Thr Ser Ile His Asp Met Asn Asp Lys Leu Glu Asn Glu Leu 
        355                 360                 365             


Ala Asn Lys Glu Ala Ile Leu Arg Gln Met Glu Glu Lys Asn Arg Gln 
    370                 375                 380                 


Leu Gln Glu Arg Leu Glu Leu Ala Glu Glu Lys Leu Gln Gln Thr Met 
385                 390                 395                 400 


Arg Lys Ala Glu Thr Leu Pro Glu Val Glu Ala Glu Leu Ala Gln Arg 
                405                 410                 415     


Ile Ala Ala Leu Thr Lys Ala Glu Glu Thr His Gly Asn Ile Glu Glu 
            420                 425                 430         


Arg Met Arg His Leu Glu Gly Gln Leu Glu Glu Lys Asn Gln Glu Leu 
        435                 440                 445             


Gln Arg Ala Arg Gln Arg Glu Lys Met Asn Glu Glu His Asn Lys Arg 
    450                 455                 460                 


Leu Ser Asp Thr Val Asp Arg Leu Leu Thr Glu Ser Asn Glu Arg Leu 
465                 470                 475                 480 


Gln Leu His Leu Lys Glu Arg Met Ala Ala Leu Glu Glu Lys Asn Val 
                485                 490                 495     


Leu Ile Gln Glu Ser Glu Thr Phe Arg Lys Asn Leu Glu Glu Ser Leu 
            500                 505                 510         


His Asp Lys Glu Ser Leu Ala Glu Glu Ile Glu Lys Leu Arg Ser Glu 
        515                 520                 525             


Leu Asp Gln Leu Lys Met Arg Thr Gly Ser Leu Ile Glu Pro Thr Ile 
    530                 535                 540                 


Pro Arg Thr His Leu Asp Thr Ser Ala Glu Leu Arg Tyr Ser Val Gly 
545                 550                 555                 560 


Ser Leu Val Asp Ser Gln Ser Asp Tyr Arg Thr Thr Lys Val Ile Arg 
                565                 570                 575     


Arg Pro Arg Arg Gly Arg Met Gly Val Arg Arg Asp Glu Pro Lys Val 
            580                 585                 590         


Lys Ser Leu Gly Asp His Glu Trp Asn Arg Thr Gln Gln Ile Gly Val 
        595                 600                 605             


Leu Ser Ser His Pro Phe Glu Ser Asp Thr Glu Met Ser Asp Ile Asp 
    610                 615                 620                 


Asp Asp Asp Arg Glu Thr Ile Phe Ser Ser Met Asp Leu Leu Ser Pro 
625                 630                 635                 640 


Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln 
                645                 650                 655     


Leu Asp Ala Ile Asn Lys Glu Ile Arg Leu Ile Gln Glu Glu Lys Glu 
            660                 665                 670         


Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Asn Arg Val Ala Ser Val 
        675                 680                 685             


Ser Leu Glu Gly Leu Asn Leu Ala Met Val His Pro Gly Thr Ser Ile 
    690                 695                 700                 


Thr Ala Ser Val Thr Ala Ser Ser Leu Ala Ser Ser Ser Pro Pro Ser 
705                 710                 715                 720 


Gly His Ser Thr Pro Lys Leu Thr Pro Arg Ser Pro Ala Arg Glu Met 
                725                 730                 735     


Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg 
            740                 745                 750         


Arg Lys Ile Ala Val Val Glu Glu Asp Gly Arg Glu Asp Lys Ala Thr 
        755                 760                 765             


Ile Lys Cys Glu Thr Ser Pro Pro Pro Thr Pro Arg Ala Leu Arg Met 
    770                 775                 780                 


Thr His Thr Leu Pro Ser Ser Tyr His Asn Asp Ala Arg Ser Ser Leu 
785                 790                 795                 800 


Ser Val Ser Leu Glu Pro Glu Ser Leu Gly Leu Gly Ser Ala Asn Ser 
                805                 810                 815     


Ser Gln Asp Ser Leu His Lys Ala Pro Lys Lys Lys Gly Ile Lys Ser 
            820                 825                 830         


Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Ala Arg Leu Gly Gln 
        835                 840                 845             


Leu Arg Gly Phe Met Glu Thr Glu Ala Ala Ala Gln Glu Ser Leu Gly 
    850                 855                 860                 


Leu Gly Lys Leu Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys 
865                 870                 875                 880 


Lys His Glu Leu Leu Glu Glu Ala Arg Arg Lys Gly Leu Pro Phe Ala 
                885                 890                 895     


Gln Trp Asp Gly Pro Thr Val Val Ala Trp Leu Glu Leu Trp Leu Gly 
            900                 905                 910         


Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly 
        915                 920                 925             


Ala Ile Met Ser Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly 
    930                 935                 940                 


Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu 
945                 950                 955                 960 


Met Val Ser Leu Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Pro 
                965                 970                 975     


Ser Gly Asn Val Trp Val Thr His Glu Glu Met Glu Asn Leu Ala Ala 
            980                 985                 990         


Pro Ala Lys Thr Lys Glu Ser Glu  Glu Gly Ser Trp Ala  Gln Cys Pro 
        995                 1000                 1005             


Val Phe  Leu Gln Thr Leu Ala  Tyr Gly Asp Met Asn  His Glu Trp 
    1010                 1015                 1020             


Ile Gly  Asn Glu Trp Leu Pro  Ser Leu Gly Leu Pro  Gln Tyr Arg 
    1025                 1030                 1035             


Ser Tyr  Phe Met Glu Cys Leu  Val Asp Ala Arg Met  Leu Asp His 
    1040                 1045                 1050             


Leu Thr  Lys Lys Asp Leu Arg  Val His Leu Lys Met  Val Asp Ser 
    1055                 1060                 1065             


Phe His  Arg Thr Ser Leu Gln  Tyr Gly Ile Met Cys  Leu Lys Arg 
    1070                 1075                 1080             


Leu Asn  Tyr Asp Arg Lys Glu  Leu Glu Arg Arg Arg  Glu Ala Ser 
    1085                 1090                 1095             


Gln His  Glu Ile Lys Asp Val  Leu Val Trp Ser Asn  Asp Arg Val 
    1100                 1105                 1110             


Ile Arg  Trp Ile Gln Ala Ile  Gly Leu Arg Glu Tyr  Ala Asn Asn 
    1115                 1120                 1125             


Ile Leu  Glu Ser Gly Val His  Gly Ser Leu Ile Ala  Leu Asp Glu 
    1130                 1135                 1140             


Asn Phe  Asp Tyr Ser Ser Leu  Ala Leu Leu Leu Gln  Ile Pro Thr 
    1145                 1150                 1155             


Gln Asn  Thr Gln Ala Arg Gln  Ile Leu Glu Arg Glu  Tyr Asn Asn 
    1160                 1165                 1170             


Leu Leu  Ala Leu Gly Thr Glu  Arg Arg Leu Asp Glu  Ser Asp Asp 
    1175                 1180                 1185             


Lys Asn  Phe Arg Arg Gly Ser  Thr Trp Arg Arg Gln  Phe Pro Pro 
    1190                 1195                 1200             


Arg Glu  Val His Gly Ile Ser  Met Met Pro Gly Ser  Ser Glu Thr 
    1205                 1210                 1215             


Leu Pro  Ala Gly Phe Arg Leu  Thr Thr Thr Ser Gly  Gln Ser Arg 
    1220                 1225                 1230             


Lys Met  Thr Thr Asp Val Ala  Ser Ser Arg Leu Gln  Arg Leu Asp 
    1235                 1240                 1245             


Asn Ser  Thr Val Arg Thr Tyr  Ser Cys 
    1250                 1255         


<210>  535
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  535
gcatccccga ccagccccaa ggtcttcccg ctgagcctct gcagcaccca gccagatggg       60

aacgtggtca tcgcctgcct ggtccagggc ttcttccccc aggagccact cagtgtgacc      120

tggagcgaaa gcggacaggg cgtgaccgcc agaaacttcc cacccagcca ggatgcctcc      180

ggggacctgt acaccacgag cagccagctg accctgccgg ccacacagtg cctagccggc      240

aagtccgtga catgccacgt gaagcactac acgaatccca gccaggatgt gactgtgccc      300

tgcccagttc cctcaactcc acctacccca tctccctcaa ctccacctac cccatctccc      360

tcatgctgcc acccccgact gtcactgcac cgaccggccc tcgaggacct gctcttaggt      420

tcagaagcga acctcacgtg cacactgacc ggcctgagag atgcctcagg tgtcaccttc      480

acctggacgc cctcaagtgg gaagagcgct gttcaaggac cacctgagcg tgacctctgt      540

ggctgctaca gcgtgtccag tgtcctgccg ggctgtgccg agccatggaa ccatgggaag      600

accttcactt gcactgctgc ctaccccgag tccaagaccc cgctaaccgc caccctctca      660

aaatccggaa acacattccg gcccgaggtc cacctgctgc cgccgccgtc ggaggagctg      720

gccctgaacg agctggtgac gctgacgtgc ctggcacgcg gcttcagccc caaggatgtg      780

ctggttcgct ggctgcaggg gtcacaggag ctgccccgcg agaagtacct gacttgggca      840

tcccggcagg agcccagcca gggcaccacc accttcgctg tgaccagcat actgcgcgtg      900

gcagccgagg actggaagaa gggggacacc ttctcctgca tggtgggcca cgaggccctg      960

ccgctggcct tcacacagaa gaccatcgac cgcttggcgg gtaaacccac ccatgtcaat     1020

gtgtctgttg tcatggcgga ggtggacggc acctgctact ga                        1062


<210>  536
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  536

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  537
<211>  3585
<212>  DNA
<213>  Homo sapiens

<400>  537
atgatgtgcg aggtgatgcc caccatcagc gaggatggcc ggcggggctc ggcgctgggc       60

ccggacgagg cgggcgggga gctggagcgc ctcatggtca cgatgctcac ggagcgcgag      120

cgcctgctgg agacgctgcg cgaggcacag gacgggttgg ctacagcgca gctgcggctg      180

cgcgagctcg gccacgagaa ggactcgctg cagcgccagc tcagcatcgc gctgccccag      240

gagtttgcag ctctgacgaa ggagctgaac ttatgtcggg agcagctgct ggagagggag      300

gaagagattg cagagctgaa ggcggaacgg aacaacacgc ggctgctcct ggaacacctg      360

gagtgcctgg tgtccaggca cgagaggtca ctgcgcatga ccgtggtgaa gcgccaggcc      420

cagtccccgg gtggggtctc ctcggaggta gaagtgctca aagctctaaa gtctctcttc      480

gagcaccaca aggccctgga tgagaaggtc cgggagcggc tgcggatggc gctggagcgc      540

gtggcagtgc tcgaggagga gctggaactg agcaatcagg agactctgaa ccttcgagaa      600

cagctgtcta ggcggcggtc agggctggaa gagccgggca aggatgggga tgggcagact      660

cttgccaatg gcctgggtcc tggcggggat tccaaccggc gcacagcaga gctggaggag      720

gccctggagc ggcagcgcgc cgaggtgtgc cagctgcggg agcgcctggc ggtgctgtgc      780

cgtcagatga gccagctgga ggaggagttg ggcaccgcgc accgtgagct gggcaaggca      840

gaggaagcca actccaagct gcagcgcgac ctcaaggagg cgctggcgca gcgggaagat      900

atggaggagc ggattacaac actggagaag cgctacctga gcgcccagcg ggaggccacg      960

tctctgcacg acgccaacga caaactggag aacgagttag ctagcaagga gtcgttgtat     1020

cggcagagtg aagagaagag ccgtcagctg gccgagtggt tggacgacgc caagcagaag     1080

ctgcagcaga cgctgcagaa agcggagacc ttgcccgaga tagaggcgca gctggcgcag     1140

cgcgtggcgg cgctcaacaa ggccgaggaa cgtcatggga attttgagga gcggcttcgg     1200

cagctggagg cccagctgga agagaagaat caagagctgc agcgggcccg gcagcgggag     1260

aagatgaacg atgaccacaa taagcggctg tccgagacgg tggacaagct gctgagcgag     1320

tccaacgagc gcttacagct tcacctcaag gagcgcatgg gggcgctgga ggagaagaac     1380

tccctgagcg aggagatagc caacatgaag aagcttcagg atgagttgct gctaaacaag     1440

gagcagctct tggccgaaat ggagcggatg cagatggaga tcgaccagct gcgggggagg     1500

ccaccatcct cctactccag gtctctccct ggcagtgccc tggagctccg ttactctcag     1560

gcacccactt taccttctgg tgcccacctg gatccctatg tggctggcag tggtcgggca     1620

ggcaagaggg gccgctggtc aggggtcaag gaggagccct ccaaggattg ggagcggtct     1680

gcccctgcgg gctccatacc acccccattc cctggggaac tggacggctc cgatgaggag     1740

gaggcagagg ggatgtttgg ggccgagctg ctgtccccca gtgggcaggc tgacgtgcag     1800

acgctggcca tcatgcttca ggagcagctg gaggccatca acaaggagat caagctgatc     1860

caagaggaga aggagacaac agaacagagg gcagaggagc tggagagtcg ggtgtccagc     1920

tctggcttgg actcgttggg ccgctaccgc agcagctgct ccctgccccc ctccctcacc     1980

acctctaccc ttgccagccc ctcccctccc agctctggcc actcaacacc ccgcctggca     2040

ccccctagcc ctgcccgtga gggcaccgac aaggctaatc atgtccctaa ggaggaagct     2100

ggagctccac gaggggaggg gccggccatc ccaggagaca ccccaccacc cactccccgc     2160

tctgcccgtc ttgagagaat gacccaggcc ttggcactgc aggcggggtc cctggaagat     2220

gggggacccc cacggggaag tgagggcacc ccagattctc tgcacaaagc ccccaagaag     2280

aagagcatca agtcatccat aggccgtctc tttggcaaga aagagaaggg acgaatggga     2340

cccccaggcc gggacagctc ttctctggct ggaacaccct cagatgagac actggccact     2400

gaccctctgg ggctagccaa gctgacaggc ccaggagaca aggaccgaag gaacaagagg     2460

aagcatgaac tcctggagga ggcctgccgc cagggcctac cttttgctgc ctgggacggg     2520

cccaccgtgg tgtcctggct ggagctgtgg gtgggcatgc ctgcctggta tgtggccgcc     2580

tgccgggcca atgtcaagag cggtgccatc atggccaacc tgtcagacac ggagatccag     2640

cgcgagatcg gcatcagcaa cccgctgcac cgactcaagc tacgcctcgc catccaggag     2700

atggtctcgc tcacctcgcc ctcagccccc gcctcctccc gcacttccac aggaaacgtg     2760

tggatgacac acgaggagat ggagtccctt acggccacga ccaagcccga gaccaaggag     2820

atcagctggg agcagatcct ggcatatggc gacatgaacc acgagtgggt ggggaacgac     2880

tggctgccca gcctggggct gccccaatac cgcagctact tcatggagtc gctggtggac     2940

gctcgaatgt tagatcacct taacaagaag gagctccggg gccaactcaa gatggtggac     3000

agctttcaca gggtgagtct acattatggg attatgtgcc tgaaacggct caactatgac     3060

cggaaggacc tggagcggag gcgggaagaa agtcagaccc agatccgaga cgtgatggtg     3120

tggtccaatg agcgggtcat gggttgggtg tccgggctgg gcctgaagga atttgccacg     3180

aacctcacgg agagcggggt acacggggca ctgctcgccc tggacgagac cttcgactac     3240

tccgacctgg ccttgctcct gcagatcccc acgcagaatg cacaggcccg gcagcttctg     3300

gagaaggaat tcagcaacct tatctcctta ggcacagaca ggcggctgga cgaggacagc     3360

gccaagtctt tcagccgctc cccatcctgg cggaagatgt tccgggagaa ggacctccga     3420

ggcgtaactc ccgactcagc tgagatgttg ccccccaact ttcgttcggc tgcagcggga     3480

gccctgggct ctccggggct ccctctccgc aagctgcagc cagaaggcca gacttctggg     3540

agttcccggg cagacggcgt ttcggtccgg acctattcct gctag                     3585


<210>  538
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Met Cys Glu Val Met Pro Thr Ile Ser Glu Asp Gly Arg Arg Gly 
1               5                   10                  15      


Ser Ala Leu Gly Pro Asp Glu Ala Gly Gly Glu Leu Glu Arg Leu Met 
            20                  25                  30          


Val Thr Met Leu Thr Glu Arg Glu Arg Leu Leu Glu Thr Leu Arg Glu 
        35                  40                  45              


Ala Gln Asp Gly Leu Ala Thr Ala Gln Leu Arg Leu Arg Glu Leu Gly 
    50                  55                  60                  


His Glu Lys Asp Ser Leu Gln Arg Gln Leu Ser Ile Ala Leu Pro Gln 
65                  70                  75                  80  


Glu Phe Ala Ala Leu Thr Lys Glu Leu Asn Leu Cys Arg Glu Gln Leu 
                85                  90                  95      


Leu Glu Arg Glu Glu Glu Ile Ala Glu Leu Lys Ala Glu Arg Asn Asn 
            100                 105                 110         


Thr Arg Leu Leu Leu Glu His Leu Glu Cys Leu Val Ser Arg His Glu 
        115                 120                 125             


Arg Ser Leu Arg Met Thr Val Val Lys Arg Gln Ala Gln Ser Pro Gly 
    130                 135                 140                 


Gly Val Ser Ser Glu Val Glu Val Leu Lys Ala Leu Lys Ser Leu Phe 
145                 150                 155                 160 


Glu His His Lys Ala Leu Asp Glu Lys Val Arg Glu Arg Leu Arg Met 
                165                 170                 175     


Ala Leu Glu Arg Val Ala Val Leu Glu Glu Glu Leu Glu Leu Ser Asn 
            180                 185                 190         


Gln Glu Thr Leu Asn Leu Arg Glu Gln Leu Ser Arg Arg Arg Ser Gly 
        195                 200                 205             


Leu Glu Glu Pro Gly Lys Asp Gly Asp Gly Gln Thr Leu Ala Asn Gly 
    210                 215                 220                 


Leu Gly Pro Gly Gly Asp Ser Asn Arg Arg Thr Ala Glu Leu Glu Glu 
225                 230                 235                 240 


Ala Leu Glu Arg Gln Arg Ala Glu Val Cys Gln Leu Arg Glu Arg Leu 
                245                 250                 255     


Ala Val Leu Cys Arg Gln Met Ser Gln Leu Glu Glu Glu Leu Gly Thr 
            260                 265                 270         


Ala His Arg Glu Leu Gly Lys Ala Glu Glu Ala Asn Ser Lys Leu Gln 
        275                 280                 285             


Arg Asp Leu Lys Glu Ala Leu Ala Gln Arg Glu Asp Met Glu Glu Arg 
    290                 295                 300                 


Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg Glu Ala Thr 
305                 310                 315                 320 


Ser Leu His Asp Ala Asn Asp Lys Leu Glu Asn Glu Leu Ala Ser Lys 
                325                 330                 335     


Glu Ser Leu Tyr Arg Gln Ser Glu Glu Lys Ser Arg Gln Leu Ala Glu 
            340                 345                 350         


Trp Leu Asp Asp Ala Lys Gln Lys Leu Gln Gln Thr Leu Gln Lys Ala 
        355                 360                 365             


Glu Thr Leu Pro Glu Ile Glu Ala Gln Leu Ala Gln Arg Val Ala Ala 
    370                 375                 380                 


Leu Asn Lys Ala Glu Glu Arg His Gly Asn Phe Glu Glu Arg Leu Arg 
385                 390                 395                 400 


Gln Leu Glu Ala Gln Leu Glu Glu Lys Asn Gln Glu Leu Gln Arg Ala 
                405                 410                 415     


Arg Gln Arg Glu Lys Met Asn Asp Asp His Asn Lys Arg Leu Ser Glu 
            420                 425                 430         


Thr Val Asp Lys Leu Leu Ser Glu Ser Asn Glu Arg Leu Gln Leu His 
        435                 440                 445             


Leu Lys Glu Arg Met Gly Ala Leu Glu Glu Lys Asn Ser Leu Ser Glu 
    450                 455                 460                 


Glu Ile Ala Asn Met Lys Lys Leu Gln Asp Glu Leu Leu Leu Asn Lys 
465                 470                 475                 480 


Glu Gln Leu Leu Ala Glu Met Glu Arg Met Gln Met Glu Ile Asp Gln 
                485                 490                 495     


Leu Arg Gly Arg Pro Pro Ser Ser Tyr Ser Arg Ser Leu Pro Gly Ser 
            500                 505                 510         


Ala Leu Glu Leu Arg Tyr Ser Gln Ala Pro Thr Leu Pro Ser Gly Ala 
        515                 520                 525             


His Leu Asp Pro Tyr Val Ala Gly Ser Gly Arg Ala Gly Lys Arg Gly 
    530                 535                 540                 


Arg Trp Ser Gly Val Lys Glu Glu Pro Ser Lys Asp Trp Glu Arg Ser 
545                 550                 555                 560 


Ala Pro Ala Gly Ser Ile Pro Pro Pro Phe Pro Gly Glu Leu Asp Gly 
                565                 570                 575     


Ser Asp Glu Glu Glu Ala Glu Gly Met Phe Gly Ala Glu Leu Leu Ser 
            580                 585                 590         


Pro Ser Gly Gln Ala Asp Val Gln Thr Leu Ala Ile Met Leu Gln Glu 
        595                 600                 605             


Gln Leu Glu Ala Ile Asn Lys Glu Ile Lys Leu Ile Gln Glu Glu Lys 
    610                 615                 620                 


Glu Thr Thr Glu Gln Arg Ala Glu Glu Leu Glu Ser Arg Val Ser Ser 
625                 630                 635                 640 


Ser Gly Leu Asp Ser Leu Gly Arg Tyr Arg Ser Ser Cys Ser Leu Pro 
                645                 650                 655     


Pro Ser Leu Thr Thr Ser Thr Leu Ala Ser Pro Ser Pro Pro Ser Ser 
            660                 665                 670         


Gly His Ser Thr Pro Arg Leu Ala Pro Pro Ser Pro Ala Arg Glu Gly 
        675                 680                 685             


Thr Asp Lys Ala Asn His Val Pro Lys Glu Glu Ala Gly Ala Pro Arg 
    690                 695                 700                 


Gly Glu Gly Pro Ala Ile Pro Gly Asp Thr Pro Pro Pro Thr Pro Arg 
705                 710                 715                 720 


Ser Ala Arg Leu Glu Arg Met Thr Gln Ala Leu Ala Leu Gln Ala Gly 
                725                 730                 735     


Ser Leu Glu Asp Gly Gly Pro Pro Arg Gly Ser Glu Gly Thr Pro Asp 
            740                 745                 750         


Ser Leu His Lys Ala Pro Lys Lys Lys Ser Ile Lys Ser Ser Ile Gly 
        755                 760                 765             


Arg Leu Phe Gly Lys Lys Glu Lys Gly Arg Met Gly Pro Pro Gly Arg 
    770                 775                 780                 


Asp Ser Ser Ser Leu Ala Gly Thr Pro Ser Asp Glu Thr Leu Ala Thr 
785                 790                 795                 800 


Asp Pro Leu Gly Leu Ala Lys Leu Thr Gly Pro Gly Asp Lys Asp Arg 
                805                 810                 815     


Arg Asn Lys Arg Lys His Glu Leu Leu Glu Glu Ala Cys Arg Gln Gly 
            820                 825                 830         


Leu Pro Phe Ala Ala Trp Asp Gly Pro Thr Val Val Ser Trp Leu Glu 
        835                 840                 845             


Leu Trp Val Gly Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn 
    850                 855                 860                 


Val Lys Ser Gly Ala Ile Met Ala Asn Leu Ser Asp Thr Glu Ile Gln 
865                 870                 875                 880 


Arg Glu Ile Gly Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu 
                885                 890                 895     


Ala Ile Gln Glu Met Val Ser Leu Thr Ser Pro Ser Ala Pro Ala Ser 
            900                 905                 910         


Ser Arg Thr Ser Thr Gly Asn Val Trp Met Thr His Glu Glu Met Glu 
        915                 920                 925             


Ser Leu Thr Ala Thr Thr Lys Pro Glu Thr Lys Glu Ile Ser Trp Glu 
    930                 935                 940                 


Gln Ile Leu Ala Tyr Gly Asp Met Asn His Glu Trp Val Gly Asn Asp 
945                 950                 955                 960 


Trp Leu Pro Ser Leu Gly Leu Pro Gln Tyr Arg Ser Tyr Phe Met Glu 
                965                 970                 975     


Ser Leu Val Asp Ala Arg Met Leu Asp His Leu Asn Lys Lys Glu Leu 
            980                 985                 990         


Arg Gly Gln Leu Lys Met Val Asp  Ser Phe His Arg Val  Ser Leu His 
        995                 1000                 1005             


Tyr Gly  Ile Met Cys Leu Lys  Arg Leu Asn Tyr Asp  Arg Lys Asp 
    1010                 1015                 1020             


Leu Glu  Arg Arg Arg Glu Glu  Ser Gln Thr Gln Ile  Arg Asp Val 
    1025                 1030                 1035             


Met Val  Trp Ser Asn Glu Arg  Val Met Gly Trp Val  Ser Gly Leu 
    1040                 1045                 1050             


Gly Leu  Lys Glu Phe Ala Thr  Asn Leu Thr Glu Ser  Gly Val His 
    1055                 1060                 1065             


Gly Ala  Leu Leu Ala Leu Asp  Glu Thr Phe Asp Tyr  Ser Asp Leu 
    1070                 1075                 1080             


Ala Leu  Leu Leu Gln Ile Pro  Thr Gln Asn Ala Gln  Ala Arg Gln 
    1085                 1090                 1095             


Leu Leu  Glu Lys Glu Phe Ser  Asn Leu Ile Ser Leu  Gly Thr Asp 
    1100                 1105                 1110             


Arg Arg  Leu Asp Glu Asp Ser  Ala Lys Ser Phe Ser  Arg Ser Pro 
    1115                 1120                 1125             


Ser Trp  Arg Lys Met Phe Arg  Glu Lys Asp Leu Arg  Gly Val Thr 
    1130                 1135                 1140             


Pro Asp  Ser Ala Glu Met Leu  Pro Pro Asn Phe Arg  Ser Ala Ala 
    1145                 1150                 1155             


Ala Gly  Ala Leu Gly Ser Pro  Gly Leu Pro Leu Arg  Lys Leu Gln 
    1160                 1165                 1170             


Pro Glu  Gly Gln Thr Ser Gly  Ser Ser Arg Ala Asp  Gly Val Ser 
    1175                 1180                 1185             


Val Arg  Thr Tyr Ser Cys 
    1190                 


<210>  539
<211>  8442
<212>  DNA
<213>  Homo sapiens

<400>  539
atgaaactta atccacagca agctccctta tatggtgatt gtgttgttac agtgctgctt       60

gctgaagagg acaaagctga agatgatgta gtgttttact tggtattttt gggttccacc      120

ctccgtcact gtacaagtac tcggaaggtc agttctgata cattggagac cattgctcct      180

ggtcatgatt gttgtgaaac agtgaaggtg cagctctgtg cttccaaaga gggccttccc      240

gtgtttgtgg tggctgaaga agactttcat ttcgtccagg atgaagcgta tgatgcagct      300

caattcctag caaccagtgc tggaaatcag caggctttga actttacccg ttttcttgac      360

cagtcaggac ccccatctgg ggatgtgaat tcccttgata agaagttggt gctggcattc      420

aggcacctga agctgcccac ggagtggaat gtattgggga cagatcagag tttgcatgat      480

gctggcccgc gagagacatt gatgcatttt gctgtgcggc tgggactgct gaggttgacg      540

tggttcctgt tgcagaagcc aggtggccgc ggagctctca gtatccacaa ccaggaaggg      600

gcgacgcctg tgagcttggc cttggagcga ggctatcaca agctgcacca gcttctaacc      660

gaggagaatg ctggagaacc agactcctgg agcagtttat cctatgaaat accgtatgga      720

gactgttctg tgaggcatca tcgagagttg gacatctata cattaacctc tgagtctgat      780

tcacatcatg aacacccatt tcctggagac ggttgcactg gaccaatttt taaacttatg      840

aacatccaac agcaactaat gaaaacaaac ctcaagcaga tggacagtct tatgccctta      900

atgatgacag cacaggatcc ttccagtgcc ccagagacag atggccagtt tcttccctgt      960

gcaccggagc ccacggaccc tcagcgactt tcttcttctg aagagactga gagcactcag     1020

tgctgcccag ggagccctgt tgcacagact gaaagtccct gtgatttgtc aagcatagtt     1080

gaggaggaga atacagaccg ttcctgtagg aagaaaaata aaggcgtgga aagaaaaggg     1140

gaagaggtgg agccagcacc tattgtggac tctggaactg tatctgatca agacagctgc     1200

cttcagagct tgcctgattg tggagtaaag ggcacggaag gcctttcgtc ctgtggaaac     1260

agaaatgaag aaactggaac aaaatcttct ggaatgccca cagaccagga gtccctgagc     1320

agtggagatg ctgtgcttca gagagacttg gtcatggagc caggcacagc ccagtattcc     1380

tctggaggtg aactgggagg catttcaaca acaaatgtca gtaccccaga cactgcaggg     1440

gaaatggaac atgggctcat gaacccagat gccactgttt ggaagaatgt gcttcaggga     1500

ggggaaagta caaaggaaag atttgagaac tctaatattg gcacagctgg agcctctgac     1560

gtgcacgtca caagtaagcc tgtggataaa atcagtgttc caaactgtgc ccctgctgcc     1620

agttccctgg atggtaacaa acctgctgag tcttcacttg catttagtaa tgaagaaacc     1680

tccactgaaa aaacagcaga aacggaaact tcacgaagtc gtgaggagag tgctgatgct     1740

ccagtagatc agaattctgt ggtgattcca gctgctgcaa aagacaagat ttcagatgga     1800

ttagaacctt atactctctt agcagcaggc ataggtgagg caatgtcacc ctcagattta     1860

gcccttcttg ggctggaaga agatgtaatg ccacaccaga actcagaaac aaattcatct     1920

catgctcaaa gccaaaaggg caaatcctca cccatttgtt ctacaactgg agacgataaa     1980

ctttgtgcag actctgcatg tcaacagaac acagtgactt ctagtggcga tttggttgca     2040

aaactgtgtg ataacatagt tagcgagtcc gaaagcacca cagcaaggca acccagctca     2100

caagatccac ccgatgcctc ccactgtgaa gacccacagg ctcatacagt cacctctgac     2160

cctgtaaggg atacccagga acgtgcggat ttttgtcctt tcaaagtggt ggataacaaa     2220

ggccaacgaa aagatgtgaa actagataaa cctttaacaa atatgcttga ggtggtttca     2280

catccacatc cagttgtccc taaaatggag aaagaactgg tgccagacca ggcagtaata     2340

tcagacagta ctttctctct ggcaaacagt ccaggcagtg aatcagtaac caaggatgac     2400

gcactttctt ttgtcccctc ccagaaagaa aagggaacag caactcctga actacataca     2460

gctacagatt atagagatgg cccagatgga aattcgaatg agcctgatac gcggccacta     2520

gaagacaggg cagtaggcct gtccacatcc tccactgctg cagagcttca gcacgggatg     2580

gggaatacca gtctcacagg acttggtgga gagcatgagg gtcccgcccc tccagcaatc     2640

ccagaagctc tgaatatcaa ggggaacact gactcttccc tgcaaagtgt gggtaaggcc     2700

actttggctt tagattcagt tttgactgaa gaaggaaaac ttctggtggt ttcagaaagc     2760

tctgcagctc aggaacaaga taaggataaa gcggtgacct gttcctctat taaggaaaat     2820

gctctctctt caggaacttt gcaggaagag cagagaacac cacctcctgg acaagatact     2880

caacaatttc atgaaaaatc aatctcagct gactgtgcca aggacaaagc acttcagcta     2940

agtaattcac cgggtgcatc ctctgccttt cttaaggcag aaactgaaca taacaaggaa     3000

gtggccccac aagtctcact gctgactcaa ggtggggctg cccagagcct ggtgccacca     3060

ggagcaagtc tggccacaga gtcaaggcag gaagccttgg gggcagagca caacagctcc     3120

gctctgttgc catgtctgtt gccagatggg tctgatgggt ccgatgctct taactgcagt     3180

cagccttctc ctctggatgt tggagtgaag aacactcaat cccagggaaa aactagtgcc     3240

tgtgaggtga gtggagatgt gacggtggat gttacagggg ttaatgctct acaaggtatg     3300

gctgagccca gaagagagaa tatatcacac aacacccaag acatcctgat tccaaacgtc     3360

ttgttgagcc aagagaagaa tgccgttcta ggtttgccag tggctctaca ggacaaagct     3420

gtgactgacc cacagggagt tggaacccca gagatgatac ctcttgattg ggagaaaggg     3480

aagctggagg gagcagacca cagctgtacc atgggtgacg ctgaggaagc ccaaatagac     3540

gatgaagcac atcctgtcct actgcagcct gttgccaagg agctccccac agacatggag     3600

ctctcagccc atgatgatgg ggccccagct ggtgtgaggg aagtcatgcg agccccgcct     3660

tcaggcaggg aaaggagcac tccctctcta ccttgcatgg tctctgccca ggacgcacct     3720

ctgcctaagg gggcagactt gatagaggag gctgccagcc gtatagtgga tgctgtcatc     3780

gaacaagtca aggccgctgg agcactgctt actgaggggg aggcctgtca catgtcactg     3840

tccagccctg agttgggtcc tctcactaaa ggactagaga gtgcttttac agaaaaagtg     3900

agtactttcc cacctgggga gagcctacca atgggcagta ctcctgagga agccacgggg     3960

agccttgcag gatgttttgc tggaagggag gagccagaga agatcatttt acctgtccag     4020

gggcctgagc cagcagcaga aatgccagac gtgaaagctg aagatgaagt ggattttaga     4080

gcaagttcaa tttctgaaga agtggctgta gggagcatag ctgctacact gaagatgaag     4140

caaggcccaa tgacccaggc gataaaccga gaaaactggt gtacaataga gccatgccct     4200

gatgcagcat ctcttctggc ttccaagcag agcccagaat gtgagaactt cctggatgtt     4260

ggactgggca gagagtgtac ctcaaaacaa ggtgtactta aaagagaatc tgggagtgat     4320

tctgacctct ttcactcacc cagtgatgac atggacagca tcatcttccc aaagccagag     4380

gaagagcatt tggcctgtga tatcaccgga tccagttcat ccaccgatga cacggcttca     4440

ctggaccgac attcttctca tggcagtgat gtgtctctct cccagatttt aaagccaaac     4500

aggtcaagag atcggcaaag ccttgatgga ttctacagcc atgggatggg agctgagggt     4560

cgagaaagtg agagtgagcc tgctgaccca ggcgacgtgg aggaggagga gatggacagt     4620

atcactgaag tgcctgcaaa ctgctctgtc ctaaggagct ccatgcgctc tctttctccc     4680

ttccggaggc acagctgggg gcctgggaaa aatgcagcca gcgatgcaga aatgaaccac     4740

cggagttcaa tgcgagttct tggggatgtt gtcaggagac ctcccattca taggagaagt     4800

ttcagtctag aaggcttgac aggaggagct ggtgtcggaa acaagccatc ctcatctcta     4860

gaagtaagct ctgcaaatgc cgaagagctc agacacccat tcagtggtga ggaacgggtt     4920

gactctttgg tgtcactttc agaagaggat ctggagtcag accagagaga acataggatg     4980

tttgatcagc agatatgtca cagatctaag cagcagggat ttaattactg tacatcagcc     5040

atttcctctc cattgacaaa atccatctca ttaatgacaa tcagccatcc tggattggac     5100

aattcacggc ccttccacag taccttccac aataccagtg ctaatctgac tgagagtata     5160

acagaagaga actataattt cctgccacat agcccctcca agaaagattc tgaatggaag     5220

agtggaacaa aagtcagtcg tacattcagc tacatcaaga ataaaatgtc tagcagcaag     5280

aagagcaaag aaaaggaaaa agaaaaagat aagattaagg agaaggagaa agattctaaa     5340

gacaaggaga aagataagaa gactgtcaac gggcacactt tcagttccat tcctgttgtg     5400

ggtcccatca gctgtagcca gtgtatgaag cccttcacca acaaagatgc ctatacttgt     5460

gcaaattgca gtgcttttgt ccacaaaggc tgccgagaaa gtctagcctc ctgtgcaaag     5520

gtcaaaatga agcagcccaa agggagcctt caggcacatg acacatcatc actgcccacg     5580

gtcattatga gaaacaagcc ctcacagccc aaggagcgtc ctcggtccgc agtcctcctg     5640

gtggatgaaa ccgctaccac cccaatattt gccaatagac gatcccagca gagtgtctcg     5700

ctctccaaaa gtgtctccat acagaacatt actggagttg gcaatgatga gaacatgtca     5760

aacacctgga aattcctgtc tcattcaaca gactcactaa ataaaatcag caaggtcaat     5820

gagtcaacag aatcacttac tgatgaggga gtaggtacag acatgaatga aggacaacta     5880

ctgggagact ttgagattga gtccaaacag ctggaagcag agtcttggag tcggataata     5940

gacagcaagt ttctaaaaca gcaaaagaaa gatgtggtca aacggcaaga agtaatatat     6000

gagttgatgc agacagagtt tcatcatgtc cgcactctca agatcatgag tggtgtgtac     6060

agccagggga tgatggcgga tctgcttttt gagcagcaga tggtagaaaa gctgttcccc     6120

tgtttggatg agctgatcag tatccatagc caattcttcc agaggattct ggagcggaag     6180

aaggagtctc tggtggataa aagtgaaaag aactttctca tcaagaggat aggggatgtg     6240

cttgtaaatc agttttcagg tgagaatgca gaacgtttaa agaagacata tggcaagttt     6300

tgtgggcaac ataaccagtc tgtaaactac ttcaaagacc tttatgccaa ggataagcgt     6360

tttcaagcct ttgtaaagaa gaagatgagc agttcagttg ttagaaggct tggaattcca     6420

gagtgcatat tgcttgtaac tcagcggatt accaagtacc cagttttatt ccaaagaata     6480

ttgcagtgta ccaaagacaa tgaagtggag caggaagatc tagcacagtc cttgagcctg     6540

gtgaaggatg tgattggagc tgtagacagc aaagtggcaa gttatgaaaa gaaagtgcgt     6600

ctcaatgaga tttatacaaa gacagatagc aagtcaatca tgaggatgaa gagtggtcag     6660

atgtttgcca aggaagattt gaaacggaag aagcttgtac gtgatgggag tgtgtttctg     6720

aagaatgcag caggaaggtt gaaagaggtt caagcagttc ttctcactga cattttagtt     6780

ttccttcaag aaaaagacca gaagtacatc tttgcatcat tggaccagaa gtcaacagtg     6840

atctctttaa agaagctgat tgtgagagaa gtggcacatg aggagaaagg tttattcctg     6900

atcagcatgg ggatgacaga tccagagatg gtagaagtcc atgccagctc caaagaggaa     6960

cgaaacagct ggattcagat cattcaggac acaatcaaca ccctgaacag agatgaagat     7020

gaaggaattc ctagtgagaa tgaggaagaa aagaaaatgt tggacaccag agcccgagaa     7080

ttaaaagaac aacttcacca gaaggaccaa aaaatcctac tcttgttgga agagaaggag     7140

atgattttcc gggacatggc tgagtgcagc acccctctcc cagaggattg ctccccaaca     7200

catagcccta gagttctctt ccgctccaac acagaagagg ctctcaaagg aggaccttta     7260

atgaaaagtg caataaatga ggtggagatc cttcagggtt tggtgagtgg aaatctggga     7320

ggcacacttg ggccgactgt cagcagcccc attgagcaag atgtggtcgg tcccgtttcc     7380

ctgccccgga gagcagagac ctttggagga tttgacagcc atcagatgaa tgcttcaaaa     7440

ggaggcgaga aggaagaggg agatgatggc caagatctta ggagaacgga atcagatagt     7500

ggcctaaaaa agggtggaaa tgctaacctg gtatttatgc ttaaaagaaa cagtgagcag     7560

gttgtccaga gcgttgttca tctctacgag ctcctcagcg ctctgcaggg tgtggtgctg     7620

cagcaggaca gctacattga ggaccagaaa ctggtgctga gcgagagggc gctcactcgc     7680

agcttgtccc gcccgagctc cctcattgag caggagaagc agcgcagcct ggagaagcag     7740

cgccaggacc tggccaacct gcagaagcag caggcccagt acctcgagga gaagcgcagg     7800

cgcgagcgtg agtgggaagc tcgtgagagg gagctgcggg agcgggaggc cctcctggcc     7860

cagcgcgagg aggaggtgca gcaggggcag caggacctgg aaaaggagcg ggaggagctc     7920

cagcagaaga agggcacata ccagtatgac ctggagcgac tgcgtgctgc ccagaaacag     7980

cttgagaggg aacaggagca gctgcgccgg gaggcagagc ggctcagcca gcggcagaca     8040

gaacgggacc tgtgtcaggt ttcccatcca cataccaagc tgatgaggat cccatcgttc     8100

ttccccagtc ctgaggagcc cccctcgcca tctgcacctt ccatagccaa atcagggtca     8160

ttggactcag aactttcagt gtccccaaaa aggaacagca tctctcggac acacaaagat     8220

aaggggcctt ttcacatact gagttcaacc agccagacaa acaaaggacc agaagggcag     8280

agccaggccc ctgcgtccac ctctgcctct acccgcctgt ttgggttaac aaagccaaag     8340

gaaaagaagg agaaaaaaaa gaagaacaaa accagccgct ctcagcccgg tgatggtccc     8400

gcgtcagaag tatcagcaga gggtgaagag atcttctgct ga                        8442


<210>  540
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Thr Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Thr Leu Arg His Cys Thr Ser Thr Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Thr Leu Glu Thr Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Thr Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Thr Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Thr Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Thr Glu Trp Asn Val Leu Gly Thr Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Thr Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Thr Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Thr Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Thr Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Thr Leu Thr 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Thr Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Thr Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Thr Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Thr Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Thr Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Thr 
                325                 330                 335     


Glu Ser Thr Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Thr Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Thr Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Thr Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Thr Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Thr Gly Thr Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Thr Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Thr Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Thr Thr Asn Val Ser Thr Pro Asp Thr Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Thr Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Thr Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Thr Ala Gly Ala Ser Asp Val His Val Thr Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Thr 
545                 550                 555                 560 


Ser Thr Glu Lys Thr Ala Glu Thr Glu Thr Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Thr Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Thr Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Thr Thr 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Thr Val 
            660                 665                 670         


Thr Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Thr Thr Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Thr Val Thr Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Thr Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Thr Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Thr 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Thr Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Thr Ala Thr Pro 
                805                 810                 815     


Glu Leu His Thr Ala Thr Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Thr Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Thr Ser Ser Thr Ala Ala Glu Leu Gln His Gly Met Gly Asn Thr Ser 
    850                 855                 860                 


Leu Thr Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Thr Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Thr Leu Ala Leu Asp Ser Val Leu Thr Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Thr Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Thr Leu Gln Glu Glu Gln Arg Thr Pro Pro Pro Gly Gln Asp Thr 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Thr Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Thr Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Thr Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Thr Gln Ser Gln  Gly Lys Thr Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Thr Val Asp  Val Thr Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Thr Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Thr Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Thr Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Thr  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Thr Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Thr Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Thr Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Thr Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Thr Glu Lys Val  Ser Thr Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Thr Pro  Glu Glu Ala Thr Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Thr Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Thr  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Thr  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Thr Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Thr Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Thr  Asp Asp Thr Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Thr Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Ser Met Arg  Val Leu Gly Asp Val  Val Arg Arg 
    1580                 1585                 1590             


Pro Pro  Ile His Arg Arg Ser  Phe Ser Leu Glu Gly  Leu Thr Gly 
    1595                 1600                 1605             


Gly Ala  Gly Val Gly Asn Lys  Pro Ser Ser Ser Leu  Glu Val Ser 
    1610                 1615                 1620             


Ser Ala  Asn Ala Glu Glu Leu  Arg His Pro Phe Ser  Gly Glu Glu 
    1625                 1630                 1635             


Arg Val  Asp Ser Leu Val Ser  Leu Ser Glu Glu Asp  Leu Glu Ser 
    1640                 1645                 1650             


Asp Gln  Arg Glu His Arg Met  Phe Asp Gln Gln Ile  Cys His Arg 
    1655                 1660                 1665             


Ser Lys  Gln Gln Gly Phe Asn  Tyr Cys Thr Ser Ala  Ile Ser Ser 
    1670                 1675                 1680             


Pro Leu  Thr Lys Ser Ile Ser  Leu Met Thr Ile Ser  His Pro Gly 
    1685                 1690                 1695             


Leu Asp  Asn Ser Arg Pro Phe  His Ser Thr Phe His  Asn Thr Ser 
    1700                 1705                 1710             


Ala Asn  Leu Thr Glu Ser Ile  Thr Glu Glu Asn Tyr  Asn Phe Leu 
    1715                 1720                 1725             


Pro His  Ser Pro Ser Lys Lys  Asp Ser Glu Trp Lys  Ser Gly Thr 
    1730                 1735                 1740             


Lys Val  Ser Arg Thr Phe Ser  Tyr Ile Lys Asn Lys  Met Ser Ser 
    1745                 1750                 1755             


Ser Lys  Lys Ser Lys Glu Lys  Glu Lys Glu Lys Asp  Lys Ile Lys 
    1760                 1765                 1770             


Glu Lys  Glu Lys Asp Ser Lys  Asp Lys Glu Lys Asp  Lys Lys Thr 
    1775                 1780                 1785             


Val Asn  Gly His Thr Phe Ser  Ser Ile Pro Val Val  Gly Pro Ile 
    1790                 1795                 1800             


Ser Cys  Ser Gln Cys Met Lys  Pro Phe Thr Asn Lys  Asp Ala Tyr 
    1805                 1810                 1815             


Thr Cys  Ala Asn Cys Ser Ala  Phe Val His Lys Gly  Cys Arg Glu 
    1820                 1825                 1830             


Ser Leu  Ala Ser Cys Ala Lys  Val Lys Met Lys Gln  Pro Lys Gly 
    1835                 1840                 1845             


Ser Leu  Gln Ala His Asp Thr  Ser Ser Leu Pro Thr  Val Ile Met 
    1850                 1855                 1860             


Arg Asn  Lys Pro Ser Gln Pro  Lys Glu Arg Pro Arg  Ser Ala Val 
    1865                 1870                 1875             


Leu Leu  Val Asp Glu Thr Ala  Thr Thr Pro Ile Phe  Ala Asn Arg 
    1880                 1885                 1890             


Arg Ser  Gln Gln Ser Val Ser  Leu Ser Lys Ser Val  Ser Ile Gln 
    1895                 1900                 1905             


Asn Ile  Thr Gly Val Gly Asn  Asp Glu Asn Met Ser  Asn Thr Trp 
    1910                 1915                 1920             


Lys Phe  Leu Ser His Ser Thr  Asp Ser Leu Asn Lys  Ile Ser Lys 
    1925                 1930                 1935             


Val Asn  Glu Ser Thr Glu Ser  Leu Thr Asp Glu Gly  Val Gly Thr 
    1940                 1945                 1950             


Asp Met  Asn Glu Gly Gln Leu  Leu Gly Asp Phe Glu  Ile Glu Ser 
    1955                 1960                 1965             


Lys Gln  Leu Glu Ala Glu Ser  Trp Ser Arg Ile Ile  Asp Ser Lys 
    1970                 1975                 1980             


Phe Leu  Lys Gln Gln Lys Lys  Asp Val Val Lys Arg  Gln Glu Val 
    1985                 1990                 1995             


Ile Tyr  Glu Leu Met Gln Thr  Glu Phe His His Val  Arg Thr Leu 
    2000                 2005                 2010             


Lys Ile  Met Ser Gly Val Tyr  Ser Gln Gly Met Met  Ala Asp Leu 
    2015                 2020                 2025             


Leu Phe  Glu Gln Gln Met Val  Glu Lys Leu Phe Pro  Cys Leu Asp 
    2030                 2035                 2040             


Glu Leu  Ile Ser Ile His Ser  Gln Phe Phe Gln Arg  Ile Leu Glu 
    2045                 2050                 2055             


Arg Lys  Lys Glu Ser Leu Val  Asp Lys Ser Glu Lys  Asn Phe Leu 
    2060                 2065                 2070             


Ile Lys  Arg Ile Gly Asp Val  Leu Val Asn Gln Phe  Ser Gly Glu 
    2075                 2080                 2085             


Asn Ala  Glu Arg Leu Lys Lys  Thr Tyr Gly Lys Phe  Cys Gly Gln 
    2090                 2095                 2100             


His Asn  Gln Ser Val Asn Tyr  Phe Lys Asp Leu Tyr  Ala Lys Asp 
    2105                 2110                 2115             


Lys Arg  Phe Gln Ala Phe Val  Lys Lys Lys Met Ser  Ser Ser Val 
    2120                 2125                 2130             


Val Arg  Arg Leu Gly Ile Pro  Glu Cys Ile Leu Leu  Val Thr Gln 
    2135                 2140                 2145             


Arg Ile  Thr Lys Tyr Pro Val  Leu Phe Gln Arg Ile  Leu Gln Cys 
    2150                 2155                 2160             


Thr Lys  Asp Asn Glu Val Glu  Gln Glu Asp Leu Ala  Gln Ser Leu 
    2165                 2170                 2175             


Ser Leu  Val Lys Asp Val Ile  Gly Ala Val Asp Ser  Lys Val Ala 
    2180                 2185                 2190             


Ser Tyr  Glu Lys Lys Val Arg  Leu Asn Glu Ile Tyr  Thr Lys Thr 
    2195                 2200                 2205             


Asp Ser  Lys Ser Ile Met Arg  Met Lys Ser Gly Gln  Met Phe Ala 
    2210                 2215                 2220             


Lys Glu  Asp Leu Lys Arg Lys  Lys Leu Val Arg Asp  Gly Ser Val 
    2225                 2230                 2235             


Phe Leu  Lys Asn Ala Ala Gly  Arg Leu Lys Glu Val  Gln Ala Val 
    2240                 2245                 2250             


Leu Leu  Thr Asp Ile Leu Val  Phe Leu Gln Glu Lys  Asp Gln Lys 
    2255                 2260                 2265             


Tyr Ile  Phe Ala Ser Leu Asp  Gln Lys Ser Thr Val  Ile Ser Leu 
    2270                 2275                 2280             


Lys Lys  Leu Ile Val Arg Glu  Val Ala His Glu Glu  Lys Gly Leu 
    2285                 2290                 2295             


Phe Leu  Ile Ser Met Gly Met  Thr Asp Pro Glu Met  Val Glu Val 
    2300                 2305                 2310             


His Ala  Ser Ser Lys Glu Glu  Arg Asn Ser Trp Ile  Gln Ile Ile 
    2315                 2320                 2325             


Gln Asp  Thr Ile Asn Thr Leu  Asn Arg Asp Glu Asp  Glu Gly Ile 
    2330                 2335                 2340             


Pro Ser  Glu Asn Glu Glu Glu  Lys Lys Met Leu Asp  Thr Arg Ala 
    2345                 2350                 2355             


Arg Glu  Leu Lys Glu Gln Leu  His Gln Lys Asp Gln  Lys Ile Leu 
    2360                 2365                 2370             


Leu Leu  Leu Glu Glu Lys Glu  Met Ile Phe Arg Asp  Met Ala Glu 
    2375                 2380                 2385             


Cys Ser  Thr Pro Leu Pro Glu  Asp Cys Ser Pro Thr  His Ser Pro 
    2390                 2395                 2400             


Arg Val  Leu Phe Arg Ser Asn  Thr Glu Glu Ala Leu  Lys Gly Gly 
    2405                 2410                 2415             


Pro Leu  Met Lys Ser Ala Ile  Asn Glu Val Glu Ile  Leu Gln Gly 
    2420                 2425                 2430             


Leu Val  Ser Gly Asn Leu Gly  Gly Thr Leu Gly Pro  Thr Val Ser 
    2435                 2440                 2445             


Ser Pro  Ile Glu Gln Asp Val  Val Gly Pro Val Ser  Leu Pro Arg 
    2450                 2455                 2460             


Arg Ala  Glu Thr Phe Gly Gly  Phe Asp Ser His Gln  Met Asn Ala 
    2465                 2470                 2475             


Ser Lys  Gly Gly Glu Lys Glu  Glu Gly Asp Asp Gly  Gln Asp Leu 
    2480                 2485                 2490             


Arg Arg  Thr Glu Ser Asp Ser  Gly Leu Lys Lys Gly  Gly Asn Ala 
    2495                 2500                 2505             


Asn Leu  Val Phe Met Leu Lys  Arg Asn Ser Glu Gln  Val Val Gln 
    2510                 2515                 2520             


Ser Val  Val His Leu Tyr Glu  Leu Leu Ser Ala Leu  Gln Gly Val 
    2525                 2530                 2535             


Val Leu  Gln Gln Asp Ser Tyr  Ile Glu Asp Gln Lys  Leu Val Leu 
    2540                 2545                 2550             


Ser Glu  Arg Ala Leu Thr Arg  Ser Leu Ser Arg Pro  Ser Ser Leu 
    2555                 2560                 2565             


Ile Glu  Gln Glu Lys Gln Arg  Ser Leu Glu Lys Gln  Arg Gln Asp 
    2570                 2575                 2580             


Leu Ala  Asn Leu Gln Lys Gln  Gln Ala Gln Tyr Leu  Glu Glu Lys 
    2585                 2590                 2595             


Arg Arg  Arg Glu Arg Glu Trp  Glu Ala Arg Glu Arg  Glu Leu Arg 
    2600                 2605                 2610             


Glu Arg  Glu Ala Leu Leu Ala  Gln Arg Glu Glu Glu  Val Gln Gln 
    2615                 2620                 2625             


Gly Gln  Gln Asp Leu Glu Lys  Glu Arg Glu Glu Leu  Gln Gln Lys 
    2630                 2635                 2640             


Lys Gly  Thr Tyr Gln Tyr Asp  Leu Glu Arg Leu Arg  Ala Ala Gln 
    2645                 2650                 2655             


Lys Gln  Leu Glu Arg Glu Gln  Glu Gln Leu Arg Arg  Glu Ala Glu 
    2660                 2665                 2670             


Arg Leu  Ser Gln Arg Gln Thr  Glu Arg Asp Leu Cys  Gln Val Ser 
    2675                 2680                 2685             


His Pro  His Thr Lys Leu Met  Arg Ile Pro Ser Phe  Phe Pro Ser 
    2690                 2695                 2700             


Pro Glu  Glu Pro Pro Ser Pro  Ser Ala Pro Ser Ile  Ala Lys Ser 
    2705                 2710                 2715             


Gly Ser  Leu Asp Ser Glu Leu  Ser Val Ser Pro Lys  Arg Asn Ser 
    2720                 2725                 2730             


Ile Ser  Arg Thr His Lys Asp  Lys Gly Pro Phe His  Ile Leu Ser 
    2735                 2740                 2745             


Ser Thr  Ser Gln Thr Asn Lys  Gly Pro Glu Gly Gln  Ser Gln Ala 
    2750                 2755                 2760             


Pro Ala  Ser Thr Ser Ala Ser  Thr Arg Leu Phe Gly  Leu Thr Lys 
    2765                 2770                 2775             


Pro Lys  Glu Lys Lys Glu Lys  Lys Lys Lys Asn Lys  Thr Ser Arg 
    2780                 2785                 2790             


Ser Gln  Pro Gly Asp Gly Pro  Ala Ser Glu Val Ser  Ala Glu Gly 
    2795                 2800                 2805             


Glu Glu  Ile Phe Cys 
    2810             


<210>  541
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  541
atggagtacc tcatcggtat ccaaggcccc gactatgttc ttgtcgcctc cgaccgggtg       60

gccgccagca atattgtcca gatgaaggac gatcatgaca agatgtttaa gatgagtgaa      120

aagatattac tcctgtgtgt tggagaggct ggagacactg tacagtttgc agaatatatt      180

cagaaaaacg tgcaacttta taagatgcga aatggatatg aattgtctcc cacggcagca      240

gctaacttca cacgccgaaa cctggctgac tgtcttcgga gtcggacccc atatcatgtg      300

aacctcctcc tggctggcta tgatgagcat gaagggccag cgctgtatta catggactac      360

ctggcagcct tggccaaggc cccttttgca gcccacggct atggtgcctt cctgactctc      420

agtatcctcg accgatacta cacaccgact atctcacgtg agagggcagt ggaactcctt      480

aggaaatgtc tggaggagct ccagaaacgc ttcatcctga atctgccaac cttcagtgtt      540

cgaatcattg acaaaaatgg catccatgac ctggataaca tttccttccc caaacagggc      600

tcctaa                                                                 606


<210>  542
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Leu Leu Ala Gly Tyr Asp Glu His Glu Gly 
            100                 105                 110         


Pro Ala Leu Tyr Tyr Met Asp Tyr Leu Ala Ala Leu Ala Lys Ala Pro 
        115                 120                 125             


Phe Ala Ala His Gly Tyr Gly Ala Phe Leu Thr Leu Ser Ile Leu Asp 
    130                 135                 140                 


Arg Tyr Tyr Thr Pro Thr Ile Ser Arg Glu Arg Ala Val Glu Leu Leu 
145                 150                 155                 160 


Arg Lys Cys Leu Glu Glu Leu Gln Lys Arg Phe Ile Leu Asn Leu Pro 
                165                 170                 175     


Thr Phe Ser Val Arg Ile Ile Asp Lys Asn Gly Ile His Asp Leu Asp 
            180                 185                 190         


Asn Ile Ser Phe Pro Lys Gln Gly Ser 
        195                 200     


<210>  543
<211>  2244
<212>  DNA
<213>  Homo sapiens

<400>  543
atgaaccact cgccgctcaa gaccgccttg gcgtacgaat gcttccagga ccaggacaac       60

tccacgttgg ctttgccgtc ggaccaaaag atgaaaacag gcacgtctgg caggcagcgc      120

gtgcaggagc aggtgatgat gaccgtcaag cggcagaagt ccaagtcttc ccagtcgtcc      180

accctgagcc actccaatcg aggttccatg tatgatggct tggctgacaa ttacaactat      240

gggaccacca gcaggagcag ctactactcc aagttccagg cagggaatgg ctcatgggga      300

tatccgatct acaatggaac cctcaagcgg gagcctgaca acaggcgctt cagctcctac      360

agccagatgg agaactggag ccggcactac ccccggggca gctgtaacac caccggcgca      420

ggcagcgaca tctgcttcat gcagaaaatc aaggcgagcc gcagtgagcc cgacctctac      480

tgtgacccac ggggcaccct gcgcaagggc acgctgggca gcaagggcca gaagaccacc      540

cagaaccgct acagctttta cagcacctgc agtggtcaga aggccataaa gaagtgccct      600

gtgcgcccgc cctcttgtgc ctccaagcag gaccctgtgt atatcccgcc catctcctgc      660

aacaaggacc tgtcctttgg ccactctagg gccagctcca agatctgcag tgaggacatc      720

gagtgcagtg ggctgaccat ccccaaggct gtgcagtacc tgagctccca ggatgagaaa      780

taccaggcca ttggggccta ttacatccag catacctgct tccaggatga atctgccaag      840

caacaggtct atcagctggg aggcatctgc aagctggtgg acctcctccg cagccccaac      900

cagaacgtcc agcaggccgc ggcaggggcc ctgcgcaacc tggtgttcag gagcaccacc      960

aacaagctgg agacccggag gcagaatggg atccgcgagg cagtcagcct cctgaggaga     1020

accgggaacg ccgagatcca gaagcagctg actgggctgc tctggaacct gtcttccact     1080

gacgagctga aggaggaact cattgccgac gccctgcctg ttctggccga ccgcgtcatc     1140

attcccttct ctggctggtg cgatggcaat agcaacatgt cccgggaagt ggtggaccct     1200

gaggtcttct tcaatgccac aggctgcttg agaaagagac tgggcatgcg ggagcttctg     1260

gctcttgttc cgcaaagggc cactagtagc agggtgaacc tgagctcggc cgatgcaggc     1320

cgccagacca tgcgtaacta ctcagggctc attgattccc tcatggccta tgtccagaac     1380

tgtgtagcgg ccagccgctg tgacgacaag tctgtggaaa actgcatgtg tgttctgcac     1440

aacctctcct accgcctgga cgccgaggtg cccacccgct accgccagct ggagtataac     1500

gcccgcaacg cctacaccga gaagtcctcc actggctgct tcagcaacaa gagcgacaag     1560

atgatgaaca acaactatga ctgccccctg cctgaggaag agaccaaccc caagggcagc     1620

ggctggttgt accattcaga tgccatccgc acctacctga acctcatggg caagagcaag     1680

aaagatgcta ccctggaggc ctgtgctggt gccctgcaga acctgacagc cagcaagggg     1740

ctgatgtcca gtggcatgag ccagttgatt gggctgaagg aaaagggcct gccacaaatt     1800

gcccgcctcc tgcaatctgg caactctgat gtggtgcggt ccggagcctc cctcctgagc     1860

aacatgtccc gccaccctct gctgcacaga gtgatgggga accaggtgtt cccggaggtg     1920

accaggctcc tcaccagcca cactggcaat accagcaact ccgaagacat cttgtcctcg     1980

gcctgctaca ctgtgaggaa cctgatggcc tcgcagccac aactggccaa gcagtacttc     2040

tccagcagca tgctcaacaa catcatcaac ctgtgccgaa gcagtgcctc acccaaggcc     2100

gcagaagctg cccggcttct cctgtctgac atgtggtcca gcaaggaact gcagggtgtc     2160

ctcagacagc aaggtttcga taggaacatg ctgggaacct tagctggggc caacagcctc     2220

aggaacttca cctcccgatt ctaa                                            2244


<210>  544
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Lys Arg Leu Gly Met 
                405                 410                 415     


Arg Glu Leu Leu Ala Leu Val Pro Gln Arg Ala Thr Ser Ser Arg Val 
            420                 425                 430         


Asn Leu Ser Ser Ala Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser 
        435                 440                 445             


Gly Leu Ile Asp Ser Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala 
    450                 455                 460                 


Ser Arg Cys Asp Asp Lys Ser Val Glu Asn Cys Met Cys Val Leu His 
465                 470                 475                 480 


Asn Leu Ser Tyr Arg Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln 
                485                 490                 495     


Leu Glu Tyr Asn Ala Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly 
            500                 505                 510         


Cys Phe Ser Asn Lys Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys 
        515                 520                 525             


Pro Leu Pro Glu Glu Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr 
    530                 535                 540                 


His Ser Asp Ala Ile Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys 
545                 550                 555                 560 


Lys Asp Ala Thr Leu Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr 
                565                 570                 575     


Ala Ser Lys Gly Leu Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu 
            580                 585                 590         


Lys Glu Lys Gly Leu Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn 
        595                 600                 605             


Ser Asp Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg 
    610                 615                 620                 


His Pro Leu Leu His Arg Val Met Gly Asn Gln Val Phe Pro Glu Val 
625                 630                 635                 640 


Thr Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp 
                645                 650                 655     


Ile Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln 
            660                 665                 670         


Pro Gln Leu Ala Lys Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile 
        675                 680                 685             


Ile Asn Leu Cys Arg Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala 
    690                 695                 700                 


Arg Leu Leu Leu Ser Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val 
705                 710                 715                 720 


Leu Arg Gln Gln Gly Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly 
                725                 730                 735     


Ala Asn Ser Leu Arg Asn Phe Thr Ser Arg Phe 
            740                 745         


<210>  545
<211>  1113
<212>  DNA
<213>  Homo sapiens

<400>  545
atgctggggg cagtggaagg ccccaggtgg aagcaggcgg aggacattag agacatctac       60

gacttccgag atgttctggg cacgggggcc ttctcggagg tgatcctggc agaagataag      120

aggacgcaga agctggtggc catcaaatgc attgccaagg aggccctgga gggcaaggaa      180

ggcagcatgg agaatgagat tgctgtcctg cacaagatca agcaccccaa cattgtagcc      240

ctggatgaca tctatgagag tgggggccac ctctacctca tcatgcagct ggtgtcgggt      300

ggggagctct ttgaccgtat tgtggaaaaa ggcttctaca cggagcggga cgccagccgc      360

ctcatcttcc aggtgctgga tgctgtgaaa tacctgcatg acctgggcat tgtacaccgg      420

gatctcaagc cagagaatct gctgtactac agcctggatg aagactccaa aatcatgatc      480

tccgactttg gcctctccaa gatggaggac ccgggcagtg tgctctccac cgcctgtgga      540

actccgggat acgtggcccc tgaagtcctg gcccagaagc cctacagcaa ggctgtggat      600

tgctggtcca taggtgtcat cgcctacatc ttgctctgcg gttaccctcc cttctatgac      660

gagaatgatg ccaaactctt tgaacagatt ttgaaggccg agtacgagtt tgactctcct      720

tactgggacg acatctctga ctctgccaaa gatttcatcc ggcacttgat ggagaaggac      780

ccagagaaaa gattcacctg tgagcaggcc ttgcagcacc catggattgc aggagataca      840

gctctagata agaatatcca ccagtcggtg agtgagcaga tcaagaagaa ctttgccaag      900

agcaagtgga agcaagcctt caatgccacg gctgtggtgc ggcacatgag gaaactgcag      960

ctgggcacca gccaggaggg gcaggggcag acggcgagcc atggggagct gctgacacca     1020

gtggctgggg ggccggcagc tggctgttgc tgtcgagact gctgcgtgga gccgggcaca     1080

gaactgtccc ccacactgcc ccaccagctc tag                                  1113


<210>  546
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Thr Gly Ala Phe Ser 
            20                  25                  30          


Glu Val Ile Leu Ala Glu Asp Lys Arg Thr Gln Lys Leu Val Ala Ile 
        35                  40                  45              


Lys Cys Ile Ala Lys Glu Ala Leu Glu Gly Lys Glu Gly Ser Met Glu 
    50                  55                  60                  


Asn Glu Ile Ala Val Leu His Lys Ile Lys His Pro Asn Ile Val Ala 
65                  70                  75                  80  


Leu Asp Asp Ile Tyr Glu Ser Gly Gly His Leu Tyr Leu Ile Met Gln 
                85                  90                  95      


Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu Lys Gly Phe 
            100                 105                 110         


Tyr Thr Glu Arg Asp Ala Ser Arg Leu Ile Phe Gln Val Leu Asp Ala 
        115                 120                 125             


Val Lys Tyr Leu His Asp Leu Gly Ile Val His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Tyr Tyr Ser Leu Asp Glu Asp Ser Lys Ile Met Ile 
145                 150                 155                 160 


Ser Asp Phe Gly Leu Ser Lys Met Glu Asp Pro Gly Ser Val Leu Ser 
                165                 170                 175     


Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala Gln 
            180                 185                 190         


Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile Ala 
        195                 200                 205             


Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu Asn Asp Ala 
    210                 215                 220                 


Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe Asp Ser Pro 
225                 230                 235                 240 


Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile Arg His Leu 
                245                 250                 255     


Met Glu Lys Asp Pro Glu Lys Arg Phe Thr Cys Glu Gln Ala Leu Gln 
            260                 265                 270         


His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asp Lys Asn Ile His Gln 
        275                 280                 285             


Ser Val Ser Glu Gln Ile Lys Lys Asn Phe Ala Lys Ser Lys Trp Lys 
    290                 295                 300                 


Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg Lys Leu Gln 
305                 310                 315                 320 


Leu Gly Thr Ser Gln Glu Gly Gln Gly Gln Thr Ala Ser His Gly Glu 
                325                 330                 335     


Leu Leu Thr Pro Val Ala Gly Gly Pro Ala Ala Gly Cys Cys Cys Arg 
            340                 345                 350         


Asp Cys Cys Val Glu Pro Gly Thr Glu Leu Ser Pro Thr Leu Pro His 
        355                 360                 365             


Gln Leu 
    370 


<210>  547
<211>  3195
<212>  DNA
<213>  Homo sapiens

<400>  547
atgaatcatg attttcaagc tcttgcatta gaatctcggg gaatgggaga gcttttgcct       60

accaaaaagt tttgggaacc tgatgattca acaaaagatg gacaaaaagg catatttctt      120

ggggatgatg aatggagaga gactgcatgg ggagcttctc accattcaat gtcccagcct      180

attatggtac agagaagatc tggacagggt tttcatggaa acagtgaagt aaatgcaata      240

ctgtctccgc gatcagaaag tggaggcctt ggtgtgagca tggtagaata tgtattaagt      300

tcttctcctg ctgataaatt ggattctcga tttaggaagg gaaattttgg cactagagat      360

gctgaaacag atggacctga gaaaggagat caaaaaggca aggcttctcc atttgaggag      420

gaccaaaaca gagatcttaa acaaggagat gatgatgatt ctaaaataaa tggcagaggt      480

ttgccaaatg gaatggatgc cgattgcaaa gattttaatc gtactcctgg aagtcgtcaa      540

gcctctccaa ctgaagtagt tgagcgcttg ggccccaata ctaatccctc agaaggactg      600

gggcctcttc ctaatcctac agctaataaa ccacttgttg aagaattttc aaatcctgaa      660

actcagaatc tggatgccat ggaacaagtt ggtctggaat ccttacagtt tgactatcct      720

ggtaatcagg taccaatgga ctcttcagga gctactgtag gcctttttga ctacaattcc      780

cagcagcagc tctttcagag gactaatgca ctaacagttc aacagttaac tgcagctcaa      840

cagcagcaat atgcattagc agcagctcag cagccacata tagctggtgt attctcagca      900

ggccttgctc cagctgcatt tgtgccaaat ccatacatta ttagtgctgc tcctccaggg      960

accgatccgt atactgcagc aggattggct gcagcagcta cattagcagg tccagcagtg     1020

gttccacctc agtattacgg cgttccatgg ggggtgtatc cagccaactt atttcagcag     1080

caagctgcag ctgcggcaaa taacacagcc agtcagcaag cagcatcaca agctcagcct     1140

ggacagcaac aggttctccg tgctggagca ggtcagcgtc ctcttactcc caatcagggt     1200

cagcaagggc agcaagcaga atcacttgcg gcagctgcag cagcaaatcc aacattggct     1260

tttggtcagg gtcttgctac tggcatgcca ggctatcaag tactagctcc aactgcctat     1320

tatgatcaga ctggtgcctt agtggttggc cctggagcaa ggactggcct tggagctcca     1380

gttcggttaa tggctccaac acctgtttta attagttcag cagcagcaca agctgcagca     1440

gcagcagcag ctggaggaac tgcaagtagc cttacaggca gcacaaatgg tctgtttcgg     1500

ccaattggca ctcagccacc acagcagcag caacagcagc caagcactaa tctgcaatct     1560

aattcatttt atggaagcag ttctttgact aatagctccc agagtagttc tttattttct     1620

catggacctg gtcaacctgg aagtacatct cttggctttg gaagtggtaa ctctttgggt     1680

gctgctatag gctcagccct cagtggattt ggttcatcag ttggcagttc tgcaagtagt     1740

agtgccacaa ggagagagtc tctatctact agctctgact tgtacaaaag atctagtagc     1800

agcctagcac ccatagggca accattttac aatagtctgg gattttcctc ctctccaagt     1860

ccaataggca tgcctctgcc aagccaaact ccaggacatt cacttacgcc accgccatca     1920

ctttcatcac atggatcctc atccagtttg catttaggag gactgacaaa tggtagtggt     1980

cgatatatct ctgcagcacc tggagcagaa gcaaaatatc gaagtgcttc aagcacttcc     2040

agtctattta gctccagcag ccagctcttt cctccttccc ggcttcggta taataggtct     2100

gatattatgc cttctggccg cagtagatta ttggaagatt tcagaaacaa ccgcttccca     2160

aaccttcagc ttagagactt gattggacat atagttgagt tttctcaaga ccagcatggt     2220

tctagattca tacagcaaaa actagagaga gctactccag ctgagcgaca gatggtattt     2280

aatgaaattc tgcaagcagc ctatcaatta atgactgatg tttttggcaa ctatgttata     2340

cagaagtttt ttgagtttgg gagtctggat caaaaattag ccctggctac tcgtattcgt     2400

ggtcatgttc tacccttagc cttgcagatg tatggctgcc gcgttattca gaaagcatta     2460

gaatctattt cttctgacca gcagagtgaa atggtaaagg agctggatgg tcatgtgctc     2520

aaatgtgtga aagatcagaa tggaaaccat gttgtacaaa aatgtatcga atgtgttcag     2580

ccacagtcac tacagttcat cattgatgct ttcaagggac aagtatttgt gctttcaact     2640

catccttatg gctgcagagt aattcagcgc atcctagagc attgcactgc agaacagacc     2700

ttacctatct tagaagaact ccaccaacat acagagcagt tggtacagga tcagtatggc     2760

aattatgtta ttcagcatgt actggaacac ggtcgacctg aagacaagag caaaattgtt     2820

tccgaaatca ggggaaaggt tttagccctg agtcaacaca aatttgccag caatgtagta     2880

gaaaagtgtg ttactcatgc ctcccgtgct gagagagctt tactgattga cgaggtttgc     2940

tgccagaatg atggtcctca cagtgcctta tacaccatga tgaaggacca gtatgccaat     3000

tacgtggttc aaaagatgat tgatatggct gaacctgctc agagaaagat aatcatgcac     3060

aagattcgac ctcacattac tactttgcgc aaatacacat acgggaagca tatactggcc     3120

aagttggaaa agtattattt gaagaatagc ccggacctag gacctattgg aggaccacca     3180

aatggaatgc tgtaa                                                      3195


<210>  548
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Asn His Asp Phe Gln Ala Leu Ala Leu Glu Ser Arg Gly Met Gly 
1               5                   10                  15      


Glu Leu Leu Pro Thr Lys Lys Phe Trp Glu Pro Asp Asp Ser Thr Lys 
            20                  25                  30          


Asp Gly Gln Lys Gly Ile Phe Leu Gly Asp Asp Glu Trp Arg Glu Thr 
        35                  40                  45              


Ala Trp Gly Ala Ser His His Ser Met Ser Gln Pro Ile Met Val Gln 
    50                  55                  60                  


Arg Arg Ser Gly Gln Gly Phe His Gly Asn Ser Glu Val Asn Ala Ile 
65                  70                  75                  80  


Leu Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu 
                85                  90                  95      


Tyr Val Leu Ser Ser Ser Pro Ala Asp Lys Leu Asp Ser Arg Phe Arg 
            100                 105                 110         


Lys Gly Asn Phe Gly Thr Arg Asp Ala Glu Thr Asp Gly Pro Glu Lys 
        115                 120                 125             


Gly Asp Gln Lys Gly Lys Ala Ser Pro Phe Glu Glu Asp Gln Asn Arg 
    130                 135                 140                 


Asp Leu Lys Gln Gly Asp Asp Asp Asp Ser Lys Ile Asn Gly Arg Gly 
145                 150                 155                 160 


Leu Pro Asn Gly Met Asp Ala Asp Cys Lys Asp Phe Asn Arg Thr Pro 
                165                 170                 175     


Gly Ser Arg Gln Ala Ser Pro Thr Glu Val Val Glu Arg Leu Gly Pro 
            180                 185                 190         


Asn Thr Asn Pro Ser Glu Gly Leu Gly Pro Leu Pro Asn Pro Thr Ala 
        195                 200                 205             


Asn Lys Pro Leu Val Glu Glu Phe Ser Asn Pro Glu Thr Gln Asn Leu 
    210                 215                 220                 


Asp Ala Met Glu Gln Val Gly Leu Glu Ser Leu Gln Phe Asp Tyr Pro 
225                 230                 235                 240 


Gly Asn Gln Val Pro Met Asp Ser Ser Gly Ala Thr Val Gly Leu Phe 
                245                 250                 255     


Asp Tyr Asn Ser Gln Gln Gln Leu Phe Gln Arg Thr Asn Ala Leu Thr 
            260                 265                 270         


Val Gln Gln Leu Thr Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala 
        275                 280                 285             


Ala Gln Gln Pro His Ile Ala Gly Val Phe Ser Ala Gly Leu Ala Pro 
    290                 295                 300                 


Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser Ala Ala Pro Pro Gly 
305                 310                 315                 320 


Thr Asp Pro Tyr Thr Ala Ala Gly Leu Ala Ala Ala Ala Thr Leu Ala 
                325                 330                 335     


Gly Pro Ala Val Val Pro Pro Gln Tyr Tyr Gly Val Pro Trp Gly Val 
            340                 345                 350         


Tyr Pro Ala Asn Leu Phe Gln Gln Gln Ala Ala Ala Ala Ala Asn Asn 
        355                 360                 365             


Thr Ala Ser Gln Gln Ala Ala Ser Gln Ala Gln Pro Gly Gln Gln Gln 
    370                 375                 380                 


Val Leu Arg Ala Gly Ala Gly Gln Arg Pro Leu Thr Pro Asn Gln Gly 
385                 390                 395                 400 


Gln Gln Gly Gln Gln Ala Glu Ser Leu Ala Ala Ala Ala Ala Ala Asn 
                405                 410                 415     


Pro Thr Leu Ala Phe Gly Gln Gly Leu Ala Thr Gly Met Pro Gly Tyr 
            420                 425                 430         


Gln Val Leu Ala Pro Thr Ala Tyr Tyr Asp Gln Thr Gly Ala Leu Val 
        435                 440                 445             


Val Gly Pro Gly Ala Arg Thr Gly Leu Gly Ala Pro Val Arg Leu Met 
    450                 455                 460                 


Ala Pro Thr Pro Val Leu Ile Ser Ser Ala Ala Ala Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Gly Gly Thr Ala Ser Ser Leu Thr Gly Ser Thr Asn 
                485                 490                 495     


Gly Leu Phe Arg Pro Ile Gly Thr Gln Pro Pro Gln Gln Gln Gln Gln 
            500                 505                 510         


Gln Pro Ser Thr Asn Leu Gln Ser Asn Ser Phe Tyr Gly Ser Ser Ser 
        515                 520                 525             


Leu Thr Asn Ser Ser Gln Ser Ser Ser Leu Phe Ser His Gly Pro Gly 
    530                 535                 540                 


Gln Pro Gly Ser Thr Ser Leu Gly Phe Gly Ser Gly Asn Ser Leu Gly 
545                 550                 555                 560 


Ala Ala Ile Gly Ser Ala Leu Ser Gly Phe Gly Ser Ser Val Gly Ser 
                565                 570                 575     


Ser Ala Ser Ser Ser Ala Thr Arg Arg Glu Ser Leu Ser Thr Ser Ser 
            580                 585                 590         


Asp Leu Tyr Lys Arg Ser Ser Ser Ser Leu Ala Pro Ile Gly Gln Pro 
        595                 600                 605             


Phe Tyr Asn Ser Leu Gly Phe Ser Ser Ser Pro Ser Pro Ile Gly Met 
    610                 615                 620                 


Pro Leu Pro Ser Gln Thr Pro Gly His Ser Leu Thr Pro Pro Pro Ser 
625                 630                 635                 640 


Leu Ser Ser His Gly Ser Ser Ser Ser Leu His Leu Gly Gly Leu Thr 
                645                 650                 655     


Asn Gly Ser Gly Arg Tyr Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys 
            660                 665                 670         


Tyr Arg Ser Ala Ser Ser Thr Ser Ser Leu Phe Ser Ser Ser Ser Gln 
        675                 680                 685             


Leu Phe Pro Pro Ser Arg Leu Arg Tyr Asn Arg Ser Asp Ile Met Pro 
    690                 695                 700                 


Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Phe Pro 
705                 710                 715                 720 


Asn Leu Gln Leu Arg Asp Leu Ile Gly His Ile Val Glu Phe Ser Gln 
                725                 730                 735     


Asp Gln His Gly Ser Arg Phe Ile Gln Gln Lys Leu Glu Arg Ala Thr 
            740                 745                 750         


Pro Ala Glu Arg Gln Met Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr 
        755                 760                 765             


Gln Leu Met Thr Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe 
    770                 775                 780                 


Glu Phe Gly Ser Leu Asp Gln Lys Leu Ala Leu Ala Thr Arg Ile Arg 
785                 790                 795                 800 


Gly His Val Leu Pro Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile 
                805                 810                 815     


Gln Lys Ala Leu Glu Ser Ile Ser Ser Asp Gln Gln Ser Glu Met Val 
            820                 825                 830         


Lys Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly 
        835                 840                 845             


Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu 
    850                 855                 860                 


Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Val Leu Ser Thr 
865                 870                 875                 880 


His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Thr 
                885                 890                 895     


Ala Glu Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu 
            900                 905                 910         


Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu 
        915                 920                 925             


Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ser Glu Ile Arg 
    930                 935                 940                 


Gly Lys Val Leu Ala Leu Ser Gln His Lys Phe Ala Ser Asn Val Val 
945                 950                 955                 960 


Glu Lys Cys Val Thr His Ala Ser Arg Ala Glu Arg Ala Leu Leu Ile 
                965                 970                 975     


Asp Glu Val Cys Cys Gln Asn Asp Gly Pro His Ser Ala Leu Tyr Thr 
            980                 985                 990         


Met Met Lys Asp Gln Tyr Ala Asn  Tyr Val Val Gln Lys  Met Ile Asp 
        995                 1000                 1005             


Met Ala  Glu Pro Ala Gln Arg  Lys Ile Ile Met His  Lys Ile Arg 
    1010                 1015                 1020             


Pro His  Ile Thr Thr Leu Arg  Lys Tyr Thr Tyr Gly  Lys His Ile 
    1025                 1030                 1035             


Leu Ala  Lys Leu Glu Lys Tyr  Tyr Leu Lys Asn Ser  Pro Asp Leu 
    1040                 1045                 1050             


Gly Pro  Ile Gly Gly Pro Pro  Asn Gly Met Leu 
    1055                 1060                 


<210>  549
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  549
atggagactg gagcgctgcg gcgcccgcaa cttctcccgt tgctgctgct gctctgcggt       60

gggtgtccca gagcaggcgg ctgcaacgag acaggcatgt tggagaggct gcccctgtgt      120

gggaaggctt tcgcagacat gatgggcaag gtggacgtct ggaagtggtg caacctgtcc      180

gagttcatcg tgtactatga gagtttcacc aactgcaccg agatggaggc caatgtcgtg      240

ggctgctact ggcccaaccc cctggcccag ggcttcatca ccggcatcca caggcagttc      300

ttctccaact gcaccgtgga cagggtccac ttggaggacc ccccagacga ggttctcatc      360

ccgctgatcg ttatacccgt cgttctgact gtcgccatgg ctggcctggt ggtgtggcgc      420

agcaaacgca ccgacacgct gctgtga                                          447


<210>  550
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  550

Met Glu Thr Gly Ala Leu Arg Arg Pro Gln Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gly Gly Cys Pro Arg Ala Gly Gly Cys Asn Glu Thr Gly 
            20                  25                  30          


Met Leu Glu Arg Leu Pro Leu Cys Gly Lys Ala Phe Ala Asp Met Met 
        35                  40                  45              


Gly Lys Val Asp Val Trp Lys Trp Cys Asn Leu Ser Glu Phe Ile Val 
    50                  55                  60                  


Tyr Tyr Glu Ser Phe Thr Asn Cys Thr Glu Met Glu Ala Asn Val Val 
65                  70                  75                  80  


Gly Cys Tyr Trp Pro Asn Pro Leu Ala Gln Gly Phe Ile Thr Gly Ile 
                85                  90                  95      


His Arg Gln Phe Phe Ser Asn Cys Thr Val Asp Arg Val His Leu Glu 
            100                 105                 110         


Asp Pro Pro Asp Glu Val Leu Ile Pro Leu Ile Val Ile Pro Val Val 
        115                 120                 125             


Leu Thr Val Ala Met Ala Gly Leu Val Val Trp Arg Ser Lys Arg Thr 
    130                 135                 140                 


Asp Thr Leu Leu 
145             


<210>  551
<211>  5613
<212>  DNA
<213>  Homo sapiens

<400>  551
atggagaacg aaatttttac tccccttctg gagcagttca tgaccagccc tttggtcact       60

tgggttaaaa cgtttggacc tctggccgca ggaaatggga ccaaccttga tgaatatgtg      120

gctttggtgg atggggtatt cttgaaccag gtcatgctcc aaattaatcc taaattggag      180

agtcagagag taaataaaaa agtcaataat gatgcctcac ttagaatgca caatctatcc      240

attttggtga gacagataaa attttattac caggagactt tgcagcaatt gatcatgatg      300

tcgttgccaa atgtcttaat cattggcaaa aatccctttt ctgaacaagg cacagaagaa      360

gttaaaaaac tgcttttact tttattgggt tgtgcagttc agtgtcagaa aaaagaggaa      420

tttattgaaa gaattcaagg tttagatttt gatacaaaag cagcggttgc cgcacatatt      480

caagaggtaa ctcataatca ggaaaatgtg tttgacctgc aatggatgga agtgactgat      540

atgtcgcagg aggacataga accactcttg aaaaatatgg cattgcatct aaaaagactt      600

atagatgaga gagatgaaca ttcagagact atcatagaac tctctgaaga gcgggatggt      660

ctccattttc taccccatgc ctcttcatct gcacagtcac cctgtggttc tccaggcatg      720

aagcgaacag aaagtcgaca acatctgtcg gtggaactgg cagatgctaa agccaagata      780

agaaggctta ggcaggaatt ggaggaaaag actgagcagt tgttggattg taaacaagaa      840

cttgagcaaa tggaaataga actcaaaagg ctgcaacaag agaacatgaa tttgctttcg      900

gatgctcgct ctgccagaat gtaccgagat gaattagatg cacttcgaga gaaagcagtc      960

agagtcgata agcttgaaag tgaagtcagc agatataaag agagactaca tgatattgaa     1020

ttttataagg caagagttga ggaattaaaa gaagacaatc aagttttatt agaaacaaaa     1080

accatgttgg aagaccaact agagggaact cgtgctcgtt ctgataaatt acatgaatta     1140

gaaaaagaga acttacaact gaaagctaaa cttcatgata tggaaatgga acgagatatg     1200

gatagaaaaa agattgaaga attaatggaa gaaaatatga ctttggaaat ggcacagaaa     1260

caaagtatgg atgaatcatt acatcttggc tgggaactgg aacagatatc cagaactagt     1320

gaactttccg aagcacccca gaaatccctg ggccatgagg tgaatgagtt gacatcaagt     1380

agattattga agctagagat ggaaaatcaa agtttgacaa aaaccgtaga agagcttcgg     1440

actactgtgg attctgtaga aggcaatgct tccaaaatcc tgaaaatgga aaaagaaaat     1500

caaaggctca gtaaaaaggt tgagattctt gaaaatgaga ttgttcaaga aaagcaaagt     1560

cttcagaatt gtcagaattt aagcaaggat ctaatgaagg agaaagctca gcttgaaaaa     1620

acaatagaaa cactgagaga aaattcagag agacagatta agatactgga acaggaaaat     1680

gaacatctga atcaaacagt gtcttcctta aggcagcggt cccagataag tgcagaagca     1740

agagtgaaag acattgaaaa agaaaacaaa attcttcatg aatctatcaa agaaacaagt     1800

agcaagctaa gcaagattga atttgaaaaa agacaaatta aaaaagaatt ggaacattat     1860

aaagaaaaag gagaacgagc tgaagaactt gaaaatgaat tgcatcatct tgaaaaagaa     1920

aatgaattat tacagaaaaa aataactaat ttaaaaatta cttgtgaaaa aattgaggcc     1980

ttagaacaag aaaattcaga gctagaaaga gaaaatagaa aattaaaaaa aacattggat     2040

agctttaaaa atctgacctt tcagttagaa tccctagaaa aagagaattc ccaacttgat     2100

gaggaaaact tagaactgcg aaggaatgta gaatctttga agtgtgcaag catgaaaatg     2160

gctcagctac agctagaaaa caaagaactg gaaagtgaaa aagagcaact taagaagggt     2220

ttggagctcc tgaaagcatc tttcaagaaa acagaacgct tagaagttag ctaccagggt     2280

ttagatatag aaaatcaaag actgcaaaaa actttagaga acagcaataa aaaaatccag     2340

caattagaga gtgaactaca agacttagag atggaaaatc aaacattgca gaaaaaccta     2400

gaagaactaa aaatatctag caaaagacta gaacagctgg aaaaagaaaa taaatcatta     2460

gagcaagaga cttctcaact ggaaaaggat aagaaacaat tggagaagga aaataagaga     2520

ctccgacaac aagcagaaat taaagatacc acattagaag aaaataatgt gaagattgga     2580

aatttggaaa aagaaaacaa aaccctatcc aaagaaattg gtatatataa agaatcttgt     2640

gtccgtctga aagaactaga aaaagaaaat aaggagcttg tgaaaagagc aactattgat     2700

ataaaaacgt tggttacact acgtgaggat ttggtgagtg aaaagttgaa gacccaacag     2760

atgaacaatg atctcgaaaa attaactcat gagcttgaga agatagggtt aaataaggag     2820

cgactcttac atgatgaaca aagtactgat gacaggtata aacttttgga atcaaaatta     2880

gaatccactc ttaagaagtc tcttgaaata aaagaagaaa aaattgctgc tttagaagct     2940

cgattagaag aatccacgaa ttataaccag caattgcgcc aagaacttaa aacagtgaaa     3000

aaaaattatg aagctctcaa acagagacaa gatgaggaaa ggatggtaca gagctctcct     3060

ccaatatctg gtgaagacaa caaatgggag cgagaaagtc aagaaacgac tagagaactt     3120

ctgaaagtta aagacagatt aattgaagta gaaagaaata atgctacact gcaagcagag     3180

aagcaagcgt tgaaaactca actgaagcaa cttgagacac agaacaataa tttgcaggct     3240

cagattcttg cacttcagag gcagacagtg tcattacaag aacagaatac cactcttcaa     3300

acacagaatg ccaagcttca ggttgaaaat tccaccctta attcccaaag tacctcactc     3360

atgaaccaga atgcccaact cctaatccag cagtcttcct tagaaaatga aaatgaatct     3420

gtaatcaaag agcgagaaga cctaaaatct ctctatgatt ctctgatcaa agatcatgaa     3480

aagctggaac ttcttcatga acgtcaggct tcagagtatg aatctcttat ctctaaacat     3540

ggaactctga agtctgccca caaaaatctt gaggtggaac atagagacct tgaagaccgt     3600

tacaatcagt tattaaaaca gaaaggacag ttggaagatt tggaaaaaat gctcaaagta     3660

gaacaggaaa aaatgctgct tgaaaataaa aatcatgaaa cagtagctgc agaatacaag     3720

aaactttgtg gtgaaaatga taggctgaat catacctata gtcaactttt aaaagagact     3780

gaagttttac aaactgacca taaaaatttg aaaagtcttc tgaataattc caaactggaa     3840

caaacaagat tagaagctga attttcaaaa ctaaaggaac aataccaaca attggatatt     3900

acatcaacca agctgaataa ccagtgtgag ttgctaagcc aacttaaagg aaatttagaa     3960

gaagaaaatc ggcatctact agatcaaatt cagacattaa tgctacagaa cagaacactt     4020

ttggagcaga atatggaaag caaggatctt tttcatgttg aacaaagaca gtacattgat     4080

aagttaaatg aattaagacg tcagaaggag aaactagaag agaaaattat ggatcaatac     4140

aaattttatg acccatctcc tcctagaagg agaggcaact ggattactct aaaaatgaga     4200

aaattgataa agtctaagaa agatattaat cgggaacgcc agaaatctct aacattaaca     4260

cccacccgct cagactccag tgaaggattt cttcagctcc ctcatcaaga cagtcaagat     4320

agttcttcag taggttcaaa ctctttagaa gatggccaga ccttggggac caagaaaagc     4380

agcatggttg cactgaaaag actgcccttt ttgaggaaca gaccgaagga taaagacaaa     4440

atgaaggcct gctaccgtcg ttccatgtcc atgaatgacc tggtgcagtc catggtccta     4500

gcaggacagt ggacaggtag tactgagaat ttggaggttc ctgatgatat ttcaacgggt     4560

aaaaggagaa aagaattggg agctatggcc ttctctacta cagccatcaa cttttcaact     4620

gtcaactctt ctgcaggctt cagatccaag cagttggtta ataataaaga tactacatcc     4680

tttgaagaca taagtccaca aggtgttagt gatgattcta gtacgggatc aagagttcat     4740

gcttcaagac cagccagcct tgatagtggc agaacatcca ctagcaatag caataataat     4800

gcttcactac atgaagtcaa agcaggtgca gttaataacc aaagcaggcc acaaagccac     4860

agcagtggag aatttagcct gcttcatgac catgaggctt ggtccagcag tggtagcagt     4920

ccaatccagt acttgaaaag acagaccaga tcaagcccag tgctccagca caaaatatct     4980

gaaacactgg agagtcgaca tcacaagatc aaaactggtt cccctggaag tgaagttgtt     5040

actctacaac agtttttgga agaaagcaat aagcttacct cagtacagat aaagtcctca     5100

agtcaagaga atcttttaga tgaagtaatg aaaagtttgt ctgtctcttc tgactttttg     5160

ggaaaagaca aaccagttag ctgtggtctg gccaggtcag taagtggaaa aaccccaggg     5220

gacttctatg atagacggac aactaagcct gagtttttga gacctggtcc tcgaaaaact     5280

gaagatacct acttcattag ttctgcggga aaacctacac caggcactca aggaaaaata     5340

aaattagtaa aagaatcttc tctgtcacga caatcaaaag atagtaaccc ttatgcaact     5400

ttacctcgtg caagcagcgt gatctcaact gccgaaggaa ctacacgaag gacaagcatc     5460

catgattttt tgaccaagga cagtagactg cctatatcag ttgattcacc accagctgct     5520

gctgacagca acaccactgc agcatctaat gtggacaaag tacaagaaag cagaaattca     5580

aaaagcaggt ctagggagca acaaagctcc taa                                  5613


<210>  552
<211>  1870
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Glu Asn Glu Ile Phe Thr Pro Leu Leu Glu Gln Phe Met Thr Ser 
1               5                   10                  15      


Pro Leu Val Thr Trp Val Lys Thr Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Thr Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Thr Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Thr Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Thr Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Thr Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Thr Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val Glu Glu Leu Arg 
465                 470                 475                 480 


Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Thr Ile Glu Thr 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys Ile Thr Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn Leu Thr Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Thr Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Thr Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Thr Asp Asp Arg Tyr Lys Leu Leu Glu Ser Lys Leu 
945                 950                 955                 960 


Glu Ser Thr Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala 
                965                 970                 975     


Ala Leu Glu Ala Arg Leu Glu Glu Ser Thr Asn Tyr Asn Gln Gln Leu 
            980                 985                 990         


Arg Gln Glu Leu Lys Thr Val Lys  Lys Asn Tyr Glu Ala  Leu Lys Gln 
        995                 1000                 1005             


Arg Gln  Asp Glu Glu Arg Met  Val Gln Ser Ser Pro  Pro Ile Ser 
    1010                 1015                 1020             


Gly Glu  Asp Asn Lys Trp Glu  Arg Glu Ser Gln Glu  Thr Thr Arg 
    1025                 1030                 1035             


Glu Leu  Leu Lys Val Lys Asp  Arg Leu Ile Glu Val  Glu Arg Asn 
    1040                 1045                 1050             


Asn Ala  Thr Leu Gln Ala Glu  Lys Gln Ala Leu Lys  Thr Gln Leu 
    1055                 1060                 1065             


Lys Gln  Leu Glu Thr Gln Asn  Asn Asn Leu Gln Ala  Gln Ile Leu 
    1070                 1075                 1080             


Ala Leu  Gln Arg Gln Thr Val  Ser Leu Gln Glu Gln  Asn Thr Thr 
    1085                 1090                 1095             


Leu Gln  Thr Gln Asn Ala Lys  Leu Gln Val Glu Asn  Ser Thr Leu 
    1100                 1105                 1110             


Asn Ser  Gln Ser Thr Ser Leu  Met Asn Gln Asn Ala  Gln Leu Leu 
    1115                 1120                 1125             


Ile Gln  Gln Ser Ser Leu Glu  Asn Glu Asn Glu Ser  Val Ile Lys 
    1130                 1135                 1140             


Glu Arg  Glu Asp Leu Lys Ser  Leu Tyr Asp Ser Leu  Ile Lys Asp 
    1145                 1150                 1155             


His Glu  Lys Leu Glu Leu Leu  His Glu Arg Gln Ala  Ser Glu Tyr 
    1160                 1165                 1170             


Glu Ser  Leu Ile Ser Lys His  Gly Thr Leu Lys Ser  Ala His Lys 
    1175                 1180                 1185             


Asn Leu  Glu Val Glu His Arg  Asp Leu Glu Asp Arg  Tyr Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Lys Gly Gln  Leu Glu Asp Leu Glu  Lys Met Leu 
    1205                 1210                 1215             


Lys Val  Glu Gln Glu Lys Met  Leu Leu Glu Asn Lys  Asn His Glu 
    1220                 1225                 1230             


Thr Val  Ala Ala Glu Tyr Lys  Lys Leu Cys Gly Glu  Asn Asp Arg 
    1235                 1240                 1245             


Leu Asn  His Thr Tyr Ser Gln  Leu Leu Lys Glu Thr  Glu Val Leu 
    1250                 1255                 1260             


Gln Thr  Asp His Lys Asn Leu  Lys Ser Leu Leu Asn  Asn Ser Lys 
    1265                 1270                 1275             


Leu Glu  Gln Thr Arg Leu Glu  Ala Glu Phe Ser Lys  Leu Lys Glu 
    1280                 1285                 1290             


Gln Tyr  Gln Gln Leu Asp Ile  Thr Ser Thr Lys Leu  Asn Asn Gln 
    1295                 1300                 1305             


Cys Glu  Leu Leu Ser Gln Leu  Lys Gly Asn Leu Glu  Glu Glu Asn 
    1310                 1315                 1320             


Arg His  Leu Leu Asp Gln Ile  Gln Thr Leu Met Leu  Gln Asn Arg 
    1325                 1330                 1335             


Thr Leu  Leu Glu Gln Asn Met  Glu Ser Lys Asp Leu  Phe His Val 
    1340                 1345                 1350             


Glu Gln  Arg Gln Tyr Ile Asp  Lys Leu Asn Glu Leu  Arg Arg Gln 
    1355                 1360                 1365             


Lys Glu  Lys Leu Glu Glu Lys  Ile Met Asp Gln Tyr  Lys Phe Tyr 
    1370                 1375                 1380             


Asp Pro  Ser Pro Pro Arg Arg  Arg Gly Asn Trp Ile  Thr Leu Lys 
    1385                 1390                 1395             


Met Arg  Lys Leu Ile Lys Ser  Lys Lys Asp Ile Asn  Arg Glu Arg 
    1400                 1405                 1410             


Gln Lys  Ser Leu Thr Leu Thr  Pro Thr Arg Ser Asp  Ser Ser Glu 
    1415                 1420                 1425             


Gly Phe  Leu Gln Leu Pro His  Gln Asp Ser Gln Asp  Ser Ser Ser 
    1430                 1435                 1440             


Val Gly  Ser Asn Ser Leu Glu  Asp Gly Gln Thr Leu  Gly Thr Lys 
    1445                 1450                 1455             


Lys Ser  Ser Met Val Ala Leu  Lys Arg Leu Pro Phe  Leu Arg Asn 
    1460                 1465                 1470             


Arg Pro  Lys Asp Lys Asp Lys  Met Lys Ala Cys Tyr  Arg Arg Ser 
    1475                 1480                 1485             


Met Ser  Met Asn Asp Leu Val  Gln Ser Met Val Leu  Ala Gly Gln 
    1490                 1495                 1500             


Trp Thr  Gly Ser Thr Glu Asn  Leu Glu Val Pro Asp  Asp Ile Ser 
    1505                 1510                 1515             


Thr Gly  Lys Arg Arg Lys Glu  Leu Gly Ala Met Ala  Phe Ser Thr 
    1520                 1525                 1530             


Thr Ala  Ile Asn Phe Ser Thr  Val Asn Ser Ser Ala  Gly Phe Arg 
    1535                 1540                 1545             


Ser Lys  Gln Leu Val Asn Asn  Lys Asp Thr Thr Ser  Phe Glu Asp 
    1550                 1555                 1560             


Ile Ser  Pro Gln Gly Val Ser  Asp Asp Ser Ser Thr  Gly Ser Arg 
    1565                 1570                 1575             


Val His  Ala Ser Arg Pro Ala  Ser Leu Asp Ser Gly  Arg Thr Ser 
    1580                 1585                 1590             


Thr Ser  Asn Ser Asn Asn Asn  Ala Ser Leu His Glu  Val Lys Ala 
    1595                 1600                 1605             


Gly Ala  Val Asn Asn Gln Ser  Arg Pro Gln Ser His  Ser Ser Gly 
    1610                 1615                 1620             


Glu Phe  Ser Leu Leu His Asp  His Glu Ala Trp Ser  Ser Ser Gly 
    1625                 1630                 1635             


Ser Ser  Pro Ile Gln Tyr Leu  Lys Arg Gln Thr Arg  Ser Ser Pro 
    1640                 1645                 1650             


Val Leu  Gln His Lys Ile Ser  Glu Thr Leu Glu Ser  Arg His His 
    1655                 1660                 1665             


Lys Ile  Lys Thr Gly Ser Pro  Gly Ser Glu Val Val  Thr Leu Gln 
    1670                 1675                 1680             


Gln Phe  Leu Glu Glu Ser Asn  Lys Leu Thr Ser Val  Gln Ile Lys 
    1685                 1690                 1695             


Ser Ser  Ser Gln Glu Asn Leu  Leu Asp Glu Val Met  Lys Ser Leu 
    1700                 1705                 1710             


Ser Val  Ser Ser Asp Phe Leu  Gly Lys Asp Lys Pro  Val Ser Cys 
    1715                 1720                 1725             


Gly Leu  Ala Arg Ser Val Ser  Gly Lys Thr Pro Gly  Asp Phe Tyr 
    1730                 1735                 1740             


Asp Arg  Arg Thr Thr Lys Pro  Glu Phe Leu Arg Pro  Gly Pro Arg 
    1745                 1750                 1755             


Lys Thr  Glu Asp Thr Tyr Phe  Ile Ser Ser Ala Gly  Lys Pro Thr 
    1760                 1765                 1770             


Pro Gly  Thr Gln Gly Lys Ile  Lys Leu Val Lys Glu  Ser Ser Leu 
    1775                 1780                 1785             


Ser Arg  Gln Ser Lys Asp Ser  Asn Pro Tyr Ala Thr  Leu Pro Arg 
    1790                 1795                 1800             


Ala Ser  Ser Val Ile Ser Thr  Ala Glu Gly Thr Thr  Arg Arg Thr 
    1805                 1810                 1815             


Ser Ile  His Asp Phe Leu Thr  Lys Asp Ser Arg Leu  Pro Ile Ser 
    1820                 1825                 1830             


Val Asp  Ser Pro Pro Ala Ala  Ala Asp Ser Asn Thr  Thr Ala Ala 
    1835                 1840                 1845             


Ser Asn  Val Asp Lys Val Gln  Glu Ser Arg Asn Ser  Lys Ser Arg 
    1850                 1855                 1860             


Ser Arg  Glu Gln Gln Ser Ser  
    1865                 1870 


<210>  553
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  553
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagt aattatttaa attggtatca acagaaacca      120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccttacac ttttggccag      300

gggaccaagc tggagatcaa acga                                             324


<210>  554
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  554

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  555
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  555
atggccaaag gtggagaagc cctgccacag ggcagcccag caccagtcca ggatccccac       60

ctcatcaagg tgacagtgaa gacgcccaaa gacaaggagg atttctcagt tacagacaca      120

tgcactatcc agcagctgaa ggaagagata tctcagcgct ttaaggccca ccccgatcag      180

cttgttctaa tctttgctgg caaaatcctc aaggatcctg actcactggc acagtgtgga      240

gtgcgagatg gcctcactgt ccacctggtc atcaagaggc agcaccgtgc catgggcaat      300

gagtgcccag ctgcctctgt ccctacccag ggcccaagtc ctggatcact ccctcagcca      360

agctccattt acccagcaga tgggccccct gcctttagct taggtctcct cacaggcctc      420

agtaggctgg gcttggccta tcgtggcttc cctgaccagc caagctccct gatgcggcag      480

catgtgtctg tgcctgagtt tgtgactcag ctcattgatg accccttcat cccgggtctg      540

ctgtccaaca caggcctagt acgccagctg gttcttgaca acccccatat gcagcagctg      600

atccagcaca accctgagat tgggcatatt cttaacaacc cggaaattat gcggcagaca      660

ctggagtttt tacgtaaccc tgccatgatg caggagatga tacgtagcca ggaccgggtg      720

ctcagtaact tggagagcat tcctggtggc tacaatgtgc tttgcactat gtacacagat      780

attatggacc caatgcttaa cgcagtccag gagcagtttg gcggcaatcc ctttgccact      840

gccactactg ataatgccac caccaccacc agccaacctt caaggatgga gaattgtgac      900

cctctcccca acccctggac ttccacacat ggaggctcag gtagcaggca aggaaggcag      960

gatggggatc aggatgcacc tgacattaga aataggtttc caaactttct gggtattata     1020

aggctctatg actatctcca gcaattacac gagaaccccc agtccctagg aacttatcta     1080

caggggactg catctgccct cagccaaagc caggaaccac caccatcagt aaacagagtt     1140

cccccatcgt caccctcatc tcaggagcct gggtcaggcc agcctctccc cgaggagtca     1200

gtagcaatca agggaaggtc ctcctgccca gctttcctga gataccccac agagaacagt     1260

actggacaag gtggagacca agatggtgca gggaaaagct ctactggaca tagcacaaac     1320

ttgcctgatc ttgtctcggg gctgggagat tctgccaaca gggttccatt tgctccctta     1380

tctttttccc ccacggcagc cattcctgga atccctgagc ctccctggct gccatccccg     1440

gcttatccaa gatctctgag gccagatggc atgaatccag ctccacagtt acaggatgag     1500

atacaaccac agctgccact gctgatgcac cttcaggcag ccatggcaaa cccccgtgcc     1560

ctgcaagccc tgcggcagat tgagcagggt ctacaggtcc tagctactga agcacctcgc     1620

ctcctactct ggttcatgcc ttgcctagca gggacgggta gtgtggcagg aggtatagag     1680

tctagagaag atccccttat gtctgaggat cctctcccaa atccacctcc tgaggtgttc     1740

ccagcactgg actctgcaga gctgggcttc ctttcccctc cctttctcca tatgctgcaa     1800

gatttagtta gtacaaatcc ccagcagctg cagcctgagg ctcactttca ggtgcagctg     1860

gagcaactgc ggtccatggg ctttctgaat cgtgaagcca atcttcaggc cctcattgct     1920

acggggggcg acgtggatgc tgctgtggag aagctgagac agtcgtag                  1968


<210>  556
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Ala Lys Gly Gly Glu Ala Leu Pro Gln Gly Ser Pro Ala Pro Val 
1               5                   10                  15      


Gln Asp Pro His Leu Ile Lys Val Thr Val Lys Thr Pro Lys Asp Lys 
            20                  25                  30          


Glu Asp Phe Ser Val Thr Asp Thr Cys Thr Ile Gln Gln Leu Lys Glu 
        35                  40                  45              


Glu Ile Ser Gln Arg Phe Lys Ala His Pro Asp Gln Leu Val Leu Ile 
    50                  55                  60                  


Phe Ala Gly Lys Ile Leu Lys Asp Pro Asp Ser Leu Ala Gln Cys Gly 
65                  70                  75                  80  


Val Arg Asp Gly Leu Thr Val His Leu Val Ile Lys Arg Gln His Arg 
                85                  90                  95      


Ala Met Gly Asn Glu Cys Pro Ala Ala Ser Val Pro Thr Gln Gly Pro 
            100                 105                 110         


Ser Pro Gly Ser Leu Pro Gln Pro Ser Ser Ile Tyr Pro Ala Asp Gly 
        115                 120                 125             


Pro Pro Ala Phe Ser Leu Gly Leu Leu Thr Gly Leu Ser Arg Leu Gly 
    130                 135                 140                 


Leu Ala Tyr Arg Gly Phe Pro Asp Gln Pro Ser Ser Leu Met Arg Gln 
145                 150                 155                 160 


His Val Ser Val Pro Glu Phe Val Thr Gln Leu Ile Asp Asp Pro Phe 
                165                 170                 175     


Ile Pro Gly Leu Leu Ser Asn Thr Gly Leu Val Arg Gln Leu Val Leu 
            180                 185                 190         


Asp Asn Pro His Met Gln Gln Leu Ile Gln His Asn Pro Glu Ile Gly 
        195                 200                 205             


His Ile Leu Asn Asn Pro Glu Ile Met Arg Gln Thr Leu Glu Phe Leu 
    210                 215                 220                 


Arg Asn Pro Ala Met Met Gln Glu Met Ile Arg Ser Gln Asp Arg Val 
225                 230                 235                 240 


Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Val Leu Cys Thr 
                245                 250                 255     


Met Tyr Thr Asp Ile Met Asp Pro Met Leu Asn Ala Val Gln Glu Gln 
            260                 265                 270         


Phe Gly Gly Asn Pro Phe Ala Thr Ala Thr Thr Asp Asn Ala Thr Thr 
        275                 280                 285             


Thr Thr Ser Gln Pro Ser Arg Met Glu Asn Cys Asp Pro Leu Pro Asn 
    290                 295                 300                 


Pro Trp Thr Ser Thr His Gly Gly Ser Gly Ser Arg Gln Gly Arg Gln 
305                 310                 315                 320 


Asp Gly Asp Gln Asp Ala Pro Asp Ile Arg Asn Arg Phe Pro Asn Phe 
                325                 330                 335     


Leu Gly Ile Ile Arg Leu Tyr Asp Tyr Leu Gln Gln Leu His Glu Asn 
            340                 345                 350         


Pro Gln Ser Leu Gly Thr Tyr Leu Gln Gly Thr Ala Ser Ala Leu Ser 
        355                 360                 365             


Gln Ser Gln Glu Pro Pro Pro Ser Val Asn Arg Val Pro Pro Ser Ser 
    370                 375                 380                 


Pro Ser Ser Gln Glu Pro Gly Ser Gly Gln Pro Leu Pro Glu Glu Ser 
385                 390                 395                 400 


Val Ala Ile Lys Gly Arg Ser Ser Cys Pro Ala Phe Leu Arg Tyr Pro 
                405                 410                 415     


Thr Glu Asn Ser Thr Gly Gln Gly Gly Asp Gln Asp Gly Ala Gly Lys 
            420                 425                 430         


Ser Ser Thr Gly His Ser Thr Asn Leu Pro Asp Leu Val Ser Gly Leu 
        435                 440                 445             


Gly Asp Ser Ala Asn Arg Val Pro Phe Ala Pro Leu Ser Phe Ser Pro 
    450                 455                 460                 


Thr Ala Ala Ile Pro Gly Ile Pro Glu Pro Pro Trp Leu Pro Ser Pro 
465                 470                 475                 480 


Ala Tyr Pro Arg Ser Leu Arg Pro Asp Gly Met Asn Pro Ala Pro Gln 
                485                 490                 495     


Leu Gln Asp Glu Ile Gln Pro Gln Leu Pro Leu Leu Met His Leu Gln 
            500                 505                 510         


Ala Ala Met Ala Asn Pro Arg Ala Leu Gln Ala Leu Arg Gln Ile Glu 
        515                 520                 525             


Gln Gly Leu Gln Val Leu Ala Thr Glu Ala Pro Arg Leu Leu Leu Trp 
    530                 535                 540                 


Phe Met Pro Cys Leu Ala Gly Thr Gly Ser Val Ala Gly Gly Ile Glu 
545                 550                 555                 560 


Ser Arg Glu Asp Pro Leu Met Ser Glu Asp Pro Leu Pro Asn Pro Pro 
                565                 570                 575     


Pro Glu Val Phe Pro Ala Leu Asp Ser Ala Glu Leu Gly Phe Leu Ser 
            580                 585                 590         


Pro Pro Phe Leu His Met Leu Gln Asp Leu Val Ser Thr Asn Pro Gln 
        595                 600                 605             


Gln Leu Gln Pro Glu Ala His Phe Gln Val Gln Leu Glu Gln Leu Arg 
    610                 615                 620                 


Ser Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala 
625                 630                 635                 640 


Thr Gly Gly Asp Val Asp Ala Ala Val Glu Lys Leu Arg Gln Ser 
                645                 650                 655 


<210>  557
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  557
atgcagccgg cagaggaggg gcccagcgtc cccaaaatct acaagcagcg cagcccctac       60

agcgtcctca agacgttccc cagcaagaga ccggcgctgg ccaagcgcta cgagcgaccc      120

accctggtgg agctgccgca cgtgcgggcg cccccgccgc ccccgccgcc cttcgcgccg      180

cacgccgccg tctccatcag cagcagcgag ccgccgccgc agcagttcca ggcgcagagc      240

tcctaccccc ccgggcccgg ccgggccgcc gccgccgctt cgtcgtcgtc gccgtcctgc      300

acgcccgcca catcccaggg ccacttgagg actccggcgc agccgccgcc cgcgtccccc      360

gccgcctcct cgtcgtcttc gttcgccgct gtcgtcaggt atggcccagg cgcggcggcg      420

gccgccggca ccggcggcac gggtagcgac agcgccagcc tggagctcag cgcagagagt      480

cgaatgatct tggatgcctt tgcccagcag tgcagtcgag ttcttagcct cttaaattgt      540

ggaggaaaac tcctggactc caaccattct cagtccatga tttcttgcgt aaagcaggaa      600

ggctcaagtt acaacgaaag acaggagcac tgtcacattg ggaaaggggt ccacagtcag      660

acctcagaca atgtagacat agagatgcag tatatgcaaa ggaaacaaca aacttctgcc      720

tttttgaggg ttttcactga ctctctacaa aattacctgc tctcgggaag ctttccaact      780

ccaaacccct cgtcagccag tgaatatggc catctggccg acgtggatcc tctgtcaacc      840

tctcctgtgc atacattagg tggctggact tccccagcaa cgtccgaatc ccatggccac      900

ccatcttcat ctacactgcc agaagaggag gaggaggagg acgaggaagg ctattgtcct      960

cgatgccaag agctggagca ggaggttatt tcactgcaac aagaaaatga agagctcaga     1020

aggaaattag agagcatccc agtgccctgc cagaccgttt tagattactt gaagatggtt     1080

ctgcagcacc acaaccaact cctgatacca cagccagctg accagccgac agagggaagc     1140

aagcagctgt tgaacaacta tcctgtctac ataacgagca aacagtggga tgaggctgta     1200

aattcttcaa agaaagatgg gagacggctc cttcgatacc tcatcagatt tgttttcaca     1260

accgatgagc ttaagtactc atgcggcctt gggaaaagga aaaggtcagt gcagtcagga     1320

gagacaggtc ccgaaagacg ccctctggat ccagttaaag taacatgcct ccgagaattc     1380

attaggatgc attgtacctc caaccccgat tggtggatgc cctcggaaga gcagataaac     1440

aaagtgttca gcgacgctgt cggtcacgcc cgacaggggc gggcggtggg gactttcctg     1500

cacaacggtg gctcatttta tgaagggatc gatcaccagg cttctcagga tgaagtcttc     1560

aataaaagtt cccaggatgg atctggggat tag                                  1593


<210>  558
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Gln Pro Ala Glu Glu Gly Pro Ser Val Pro Lys Ile Tyr Lys Gln 
1               5                   10                  15      


Arg Ser Pro Tyr Ser Val Leu Lys Thr Phe Pro Ser Lys Arg Pro Ala 
            20                  25                  30          


Leu Ala Lys Arg Tyr Glu Arg Pro Thr Leu Val Glu Leu Pro His Val 
        35                  40                  45              


Arg Ala Pro Pro Pro Pro Pro Pro Pro Phe Ala Pro His Ala Ala Val 
    50                  55                  60                  


Ser Ile Ser Ser Ser Glu Pro Pro Pro Gln Gln Phe Gln Ala Gln Ser 
65                  70                  75                  80  


Ser Tyr Pro Pro Gly Pro Gly Arg Ala Ala Ala Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser Pro Ser Cys Thr Pro Ala Thr Ser Gln Gly His Leu Arg Thr Pro 
            100                 105                 110         


Ala Gln Pro Pro Pro Ala Ser Pro Ala Ala Ser Ser Ser Ser Ser Phe 
        115                 120                 125             


Ala Ala Val Val Arg Tyr Gly Pro Gly Ala Ala Ala Ala Ala Gly Thr 
    130                 135                 140                 


Gly Gly Thr Gly Ser Asp Ser Ala Ser Leu Glu Leu Ser Ala Glu Ser 
145                 150                 155                 160 


Arg Met Ile Leu Asp Ala Phe Ala Gln Gln Cys Ser Arg Val Leu Ser 
                165                 170                 175     


Leu Leu Asn Cys Gly Gly Lys Leu Leu Asp Ser Asn His Ser Gln Ser 
            180                 185                 190         


Met Ile Ser Cys Val Lys Gln Glu Gly Ser Ser Tyr Asn Glu Arg Gln 
        195                 200                 205             


Glu His Cys His Ile Gly Lys Gly Val His Ser Gln Thr Ser Asp Asn 
    210                 215                 220                 


Val Asp Ile Glu Met Gln Tyr Met Gln Arg Lys Gln Gln Thr Ser Ala 
225                 230                 235                 240 


Phe Leu Arg Val Phe Thr Asp Ser Leu Gln Asn Tyr Leu Leu Ser Gly 
                245                 250                 255     


Ser Phe Pro Thr Pro Asn Pro Ser Ser Ala Ser Glu Tyr Gly His Leu 
            260                 265                 270         


Ala Asp Val Asp Pro Leu Ser Thr Ser Pro Val His Thr Leu Gly Gly 
        275                 280                 285             


Trp Thr Ser Pro Ala Thr Ser Glu Ser His Gly His Pro Ser Ser Ser 
    290                 295                 300                 


Thr Leu Pro Glu Glu Glu Glu Glu Glu Asp Glu Glu Gly Tyr Cys Pro 
305                 310                 315                 320 


Arg Cys Gln Glu Leu Glu Gln Glu Val Ile Ser Leu Gln Gln Glu Asn 
                325                 330                 335     


Glu Glu Leu Arg Arg Lys Leu Glu Ser Ile Pro Val Pro Cys Gln Thr 
            340                 345                 350         


Val Leu Asp Tyr Leu Lys Met Val Leu Gln His His Asn Gln Leu Leu 
        355                 360                 365             


Ile Pro Gln Pro Ala Asp Gln Pro Thr Glu Gly Ser Lys Gln Leu Leu 
    370                 375                 380                 


Asn Asn Tyr Pro Val Tyr Ile Thr Ser Lys Gln Trp Asp Glu Ala Val 
385                 390                 395                 400 


Asn Ser Ser Lys Lys Asp Gly Arg Arg Leu Leu Arg Tyr Leu Ile Arg 
                405                 410                 415     


Phe Val Phe Thr Thr Asp Glu Leu Lys Tyr Ser Cys Gly Leu Gly Lys 
            420                 425                 430         


Arg Lys Arg Ser Val Gln Ser Gly Glu Thr Gly Pro Glu Arg Arg Pro 
        435                 440                 445             


Leu Asp Pro Val Lys Val Thr Cys Leu Arg Glu Phe Ile Arg Met His 
    450                 455                 460                 


Cys Thr Ser Asn Pro Asp Trp Trp Met Pro Ser Glu Glu Gln Ile Asn 
465                 470                 475                 480 


Lys Val Phe Ser Asp Ala Val Gly His Ala Arg Gln Gly Arg Ala Val 
                485                 490                 495     


Gly Thr Phe Leu His Asn Gly Gly Ser Phe Tyr Glu Gly Ile Asp His 
            500                 505                 510         


Gln Ala Ser Gln Asp Glu Val Phe Asn Lys Ser Ser Gln Asp Gly Ser 
        515                 520                 525             


Gly Asp 
    530 


<210>  559
<211>  1938
<212>  DNA
<213>  Homo sapiens

<400>  559
atgccgagga gccggggcgg ccgcgccgcg ccggggccgc cgccgccgcc gccgccgccg       60

ggccaggccc cgcgctggag ccgctggcgg gtccctgggc ggctgctgct gctgctgctg      120

cccgcgctct gctgcctccc gggcgccgcg cgggcggcgg cggcggcggc gggggcaggg      180

aaccgggcag cggtggcggt ggcggtggcg cgggcggacg aggcggaggc gcccttcgcc      240

gggcagaact ggttaaagtc ctatggctat ctgcttccct atgactcacg ggcatctgcg      300

ctgcactcag cgaaggcctt gcagtcggca gtctccacta tgcagcagtt ttacgggatc      360

ccggtcaccg gtgtgttgga tcagacaacg atcgagtgga tgaagaaacc ccgatgtggt      420

gtccctgatc acccccactt aagccgtagg cggagaaaca agcgctatgc cctgactgga      480

cagaagtgga ggcaaaaaca catcacctac agcattcaca actatacccc aaaagtgggt      540

gagctagaca cgcggaaagc tattcgccag gctttcgatg tgtggcagaa ggtgacccca      600

ctgacctttg aagaggtgcc ataccatgag atcaaaagtg accggaagga ggcagacatc      660

atgatctttt ttgcttctgg tttccatggc gacagctccc catttgatgg agaaggggga      720

ttcctggccc atgcctactt ccctggccca gggattggag gagacaccca ctttgactcc      780

gatgagccat ggacgctagg aaatgccaac catgacggga acgacctctt cctggtggct      840

gtgcatgagc tgggccacgc gctgggactg gagcactcca gcgaccccag cgccatcatg      900

gcgcccttct accagtacat ggagacgcac aacttcaagc tgccccagga cgatctccag      960

ggcatccaga agatctatgg acccccagcc gagcctctgg agcccacaag gccactccct     1020

acactccccg tccgcaggat ccactcacca tcggagagga aacacgagcg ccagcccagg     1080

ccccctcggc cgcccctcgg ggaccggcca tccacaccag gcaccaaacc caacatctgt     1140

gacggcaact tcaacacagt ggccctcttc cggggcgaga tgtttgtctt taaggatcgc     1200

tggttctggc gtctgcgcaa taaccgagtg caggagggct accccatgca gatcgagcag     1260

ttctggaagg gcctgcctgc ccgcatcgac gcagcctatg aaagggccga tgggagattt     1320

gtcttcttca aaggtgacaa gtattgggtg tttaaggagg tgacggtgga gcctgggtac     1380

ccccacagcc tgggggagct gggcagctgt ttgccccgtg aaggcattga cacagctctg     1440

cgctgggaac ctgtgggcaa gacctacttt ttcaaaggcg agcggtactg gcgctacagc     1500

gaggagcggc gggccacgga ccctggctac cctaagccca tcaccgtgtg gaagggcatc     1560

ccacaggctc cccaaggagc cttcatcagc aaggaaggat attacaccta tttctacaag     1620

ggccgggact actggaagtt tgacaaccag aaactgagcg tggagccagg ctacccgcgc     1680

aacatcctgc gtgactggat gggctgcaac cagaaggagg tggagcggcg gaaggagcgg     1740

cggctgcccc aggacgacgt ggacatcatg gtgaccatca acgatgtgcc gggctccgtg     1800

aacgccgtgg ccgtggtcat cccctgcatc ctgtccctct gcatcctggt gctggtctac     1860

accatcttcc agttcaagaa caagacaggc cctcagcctg tcacctacta taagcggcca     1920

gtccaggaat gggtgtga                                                   1938


<210>  560
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  560

Met Pro Arg Ser Arg Gly Gly Arg Ala Ala Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Gly Gln Ala Pro Arg Trp Ser Arg Trp Arg Val Pro 
            20                  25                  30          


Gly Arg Leu Leu Leu Leu Leu Leu Pro Ala Leu Cys Cys Leu Pro Gly 
        35                  40                  45              


Ala Ala Arg Ala Ala Ala Ala Ala Ala Gly Ala Gly Asn Arg Ala Ala 
    50                  55                  60                  


Val Ala Val Ala Val Ala Arg Ala Asp Glu Ala Glu Ala Pro Phe Ala 
65                  70                  75                  80  


Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser 
                85                  90                  95      


Arg Ala Ser Ala Leu His Ser Ala Lys Ala Leu Gln Ser Ala Val Ser 
            100                 105                 110         


Thr Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln 
        115                 120                 125             


Thr Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His 
    130                 135                 140                 


Pro His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly 
145                 150                 155                 160 


Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr 
                165                 170                 175     


Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe 
            180                 185                 190         


Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr 
        195                 200                 205             


His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe 
    210                 215                 220                 


Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly 
225                 230                 235                 240 


Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr 
                245                 250                 255     


His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp 
            260                 265                 270         


Gly Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu 
        275                 280                 285             


Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr 
    290                 295                 300                 


Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln 
305                 310                 315                 320 


Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr 
                325                 330                 335     


Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu 
            340                 345                 350         


Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp 
        355                 360                 365             


Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe 
    370                 375                 380                 


Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg 
385                 390                 395                 400 


Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met 
                405                 410                 415     


Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala 
            420                 425                 430         


Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr 
        435                 440                 445             


Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu 
    450                 455                 460                 


Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu 
465                 470                 475                 480 


Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr 
                485                 490                 495     


Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys 
            500                 505                 510         


Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe 
        515                 520                 525             


Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr 
    530                 535                 540                 


Trp Lys Phe Asp Asn Gln Lys Leu Ser Val Glu Pro Gly Tyr Pro Arg 
545                 550                 555                 560 


Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val Glu Arg 
                565                 570                 575     


Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met Val Thr 
            580                 585                 590         


Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val Ile Pro 
        595                 600                 605             


Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile Phe Gln 
    610                 615                 620                 


Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr Tyr Tyr Lys Arg Pro 
625                 630                 635                 640 


Val Gln Glu Trp Val 
                645 


<210>  561
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  561
atggtgttcc tggtggcctg cgcgctgcac atcgccctgg acctgctgcc caggctggag       60

cgacgcggcg cgcggccctc gggggagccc ggctgttcgt gcgcgcagcc cgccgccgag      120

gtggccgcgc ccggctgggc ccaggttcgg ggccgccccg gggagccccc ggccgcctcc      180

tccgccgccg gcgacgcggg ctggcccaac aagcacacgc tccgcatcct gcaggacttc      240

agctccgacc cctcctccaa cctctcgtcc cactcgctgg agaaactgcc gcccgcggcc      300

gagccggccg agcgcgcctt gcgggggcgg gatcccggcg ccctaagacc ccacgacccc      360

gcgcaccggc cgctgctgcg agaccccggc ccgcgtcggt ccgagtcgcc ccccggcccc      420

ggcggagacg cctccctcct ggccaggctg ttcgagcacc cgctttaccg ggtggcggtt      480

ccgccgctca cggaggagga cgtcctgttc aatgtgaaca gcgacaccag gctcagcccc      540

aaagcggcgg agaacccgga ctggccgcat gcgggtgctg aaggtgcaga attcctctcc      600

cccggggagg cggccgtgga ctcctatccc aactggctca agttccacat tggtatcaac      660

cggtacgagc tgtactccag acacaacccg gccatcgagg ccctgctgca cgacctcagc      720

tcccagagga tcaccagcgt ggccatgaag tcggggggca cgcagctgaa gctcatcatg      780

accttccaga attacgggca agcgctgttc aaacccatga aacaaacgag ggagcaggag      840

acaccccctg acttttttta tttctctgac tacgagaggc acaatgcgga gattgctgcc      900

ttccacctgg acaggatcct ggacttccgc cgggtccctc ccgtggccgg caggatggtc      960

aacatgacca aggagatccg ggacgtcaca cgggacaaga agctctggag gaccttcttc     1020

atctctccag ccaacaacat ctgcttctac ggcgagtgtt cctactactg ctccacggag     1080

cacgccctgt gcgggaagcc agaccagatc gagggctcgc tggcggcctt cctgcccgac     1140

ctgtccctgg ccaagaggaa gacctggcgg aacccttggc ggcgttccta ccacaagcgc     1200

aagaaggccg agtgggaggt ggaccctgac tactgcgagg aggtgaagca gacaccgccc     1260

tacgacagca gccaccgcat cctggacgtc atggacatga cgatcttcga cttcctcatg     1320

ggaaacatgg accgtcacca ctacgagact tttgagaagt ttgggaatga aacgttcatc     1380

atccacttag acaatggaag agggtttggg aagtattcgc acgacgagct ctccatcctg     1440

gtgccgctac agcagtgctg caggatccgg aagtccacct acctgcgtct gcagctcctg     1500

gccaaggagg agtacaagct gagcctgctg atggccgagt ctctgcgggg ggaccaggtg     1560

gcacccgtgc tgtaccagcc gcacctggag gccctggacc ggcggctccg cgtcgtgcta     1620

aaggccgtcc gggactgcgt ggagaggaac gggctccaca gcgtggtgga tgacgacctg     1680

gacactgagc acagagccgc ctcggcgagg tag                                  1713


<210>  562
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Val Phe Leu Val Ala Cys Ala Leu His Ile Ala Leu Asp Leu Leu 
1               5                   10                  15      


Pro Arg Leu Glu Arg Arg Gly Ala Arg Pro Ser Gly Glu Pro Gly Cys 
            20                  25                  30          


Ser Cys Ala Gln Pro Ala Ala Glu Val Ala Ala Pro Gly Trp Ala Gln 
        35                  40                  45              


Val Arg Gly Arg Pro Gly Glu Pro Pro Ala Ala Ser Ser Ala Ala Gly 
    50                  55                  60                  


Asp Ala Gly Trp Pro Asn Lys His Thr Leu Arg Ile Leu Gln Asp Phe 
65                  70                  75                  80  


Ser Ser Asp Pro Ser Ser Asn Leu Ser Ser His Ser Leu Glu Lys Leu 
                85                  90                  95      


Pro Pro Ala Ala Glu Pro Ala Glu Arg Ala Leu Arg Gly Arg Asp Pro 
            100                 105                 110         


Gly Ala Leu Arg Pro His Asp Pro Ala His Arg Pro Leu Leu Arg Asp 
        115                 120                 125             


Pro Gly Pro Arg Arg Ser Glu Ser Pro Pro Gly Pro Gly Gly Asp Ala 
    130                 135                 140                 


Ser Leu Leu Ala Arg Leu Phe Glu His Pro Leu Tyr Arg Val Ala Val 
145                 150                 155                 160 


Pro Pro Leu Thr Glu Glu Asp Val Leu Phe Asn Val Asn Ser Asp Thr 
                165                 170                 175     


Arg Leu Ser Pro Lys Ala Ala Glu Asn Pro Asp Trp Pro His Ala Gly 
            180                 185                 190         


Ala Glu Gly Ala Glu Phe Leu Ser Pro Gly Glu Ala Ala Val Asp Ser 
        195                 200                 205             


Tyr Pro Asn Trp Leu Lys Phe His Ile Gly Ile Asn Arg Tyr Glu Leu 
    210                 215                 220                 


Tyr Ser Arg His Asn Pro Ala Ile Glu Ala Leu Leu His Asp Leu Ser 
225                 230                 235                 240 


Ser Gln Arg Ile Thr Ser Val Ala Met Lys Ser Gly Gly Thr Gln Leu 
                245                 250                 255     


Lys Leu Ile Met Thr Phe Gln Asn Tyr Gly Gln Ala Leu Phe Lys Pro 
            260                 265                 270         


Met Lys Gln Thr Arg Glu Gln Glu Thr Pro Pro Asp Phe Phe Tyr Phe 
        275                 280                 285             


Ser Asp Tyr Glu Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp 
    290                 295                 300                 


Arg Ile Leu Asp Phe Arg Arg Val Pro Pro Val Ala Gly Arg Met Val 
305                 310                 315                 320 


Asn Met Thr Lys Glu Ile Arg Asp Val Thr Arg Asp Lys Lys Leu Trp 
                325                 330                 335     


Arg Thr Phe Phe Ile Ser Pro Ala Asn Asn Ile Cys Phe Tyr Gly Glu 
            340                 345                 350         


Cys Ser Tyr Tyr Cys Ser Thr Glu His Ala Leu Cys Gly Lys Pro Asp 
        355                 360                 365             


Gln Ile Glu Gly Ser Leu Ala Ala Phe Leu Pro Asp Leu Ser Leu Ala 
    370                 375                 380                 


Lys Arg Lys Thr Trp Arg Asn Pro Trp Arg Arg Ser Tyr His Lys Arg 
385                 390                 395                 400 


Lys Lys Ala Glu Trp Glu Val Asp Pro Asp Tyr Cys Glu Glu Val Lys 
                405                 410                 415     


Gln Thr Pro Pro Tyr Asp Ser Ser His Arg Ile Leu Asp Val Met Asp 
            420                 425                 430         


Met Thr Ile Phe Asp Phe Leu Met Gly Asn Met Asp Arg His His Tyr 
        435                 440                 445             


Glu Thr Phe Glu Lys Phe Gly Asn Glu Thr Phe Ile Ile His Leu Asp 
    450                 455                 460                 


Asn Gly Arg Gly Phe Gly Lys Tyr Ser His Asp Glu Leu Ser Ile Leu 
465                 470                 475                 480 


Val Pro Leu Gln Gln Cys Cys Arg Ile Arg Lys Ser Thr Tyr Leu Arg 
                485                 490                 495     


Leu Gln Leu Leu Ala Lys Glu Glu Tyr Lys Leu Ser Leu Leu Met Ala 
            500                 505                 510         


Glu Ser Leu Arg Gly Asp Gln Val Ala Pro Val Leu Tyr Gln Pro His 
        515                 520                 525             


Leu Glu Ala Leu Asp Arg Arg Leu Arg Val Val Leu Lys Ala Val Arg 
    530                 535                 540                 


Asp Cys Val Glu Arg Asn Gly Leu His Ser Val Val Asp Asp Asp Leu 
545                 550                 555                 560 


Asp Thr Glu His Arg Ala Ala Ser Ala Arg 
                565                 570 


<210>  563
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  563
atggacctaa tgaacgggca ggcaagcagt gtcaatattg cagctactgc ttctgagaaa       60

agtagcagct ctgaatcctt aagtgacaaa ggctctgaat tgaagaaaag ctttgatgct      120

gtggtattcg atgttcttaa ggttacacca gaagaatatg cgggtcagat aacattaatg      180

gatgttccag tatttaaagc tattcaacca gatgagcttt caagttgtgg atggaataaa      240

aaagaaaaat atagttctgc accaaatgca gttgccttca caagaagatt caatcatgta      300

agcttttggg ttgttagaga gattcttcat gctcaaacat taaaaattag agcagaagtt      360

ttgagccact atattaaaac tgctaagaaa ctgtatgagc tgaataacct tcatgcactt      420

atggcagtgg tttctggcct acagagtgcc ccaattttca ggttgactaa aacatgggcg      480

ttattaagtc gaaaagacaa aactaccttt gaaaaattag aatatgtaat gagtaaagaa      540

gataactaca aaagactcag agactatata agtagcttaa agatgacacc ttgcattccc      600

tatttaggta tctatttgtc agatttaaca tacatcgatt cagcataccc atcaactggc      660

agcattctag aaaatgagca aagatcaaat ttaatgaata atatccttcg aataatttct      720

gatttacagc agtcttgtga atatgatatt cccatgttgc ctcatgtcca aaaatatctc      780

aactctgttc agtatataga agaactacaa aaatttgtgg aagacgataa ttacaagctt      840

tcattaaaga tagaaccagg gacaagcacc ccacgttctg ctgcttccag agaagattta      900

gtaggtcctg aagtaggagc gtctccacag agtggacgaa aaagtgtggc agctgaagga      960

gccttgctcc cacagacacc gccatcccct cggaatctga ttccacatgg acataggaag     1020

tgccatagtt tgggttataa tttcattcat aaaatgaaca cagcagaatt taagagtgca     1080

acgtttccaa atgcaggacc aagacatctg ttagatgata gcgtcatgga gccccatgcg     1140

ccatctcgag gccaagctga aagttctact ctttctagtg gaatatcaat aggtagcagc     1200

gatggttctg aactaagtga agagacctca tggcctgctt ttgaaaggaa cagattatac     1260

cattctctcg gcccggtgac aagagtggca cgaaatggct atcgaagtca catgaaggcc     1320

agcagttctg cagaatcaga agatttggca gtacatttat atccaggagc tgttactatt     1380

caaggtgttc tcaggagaaa aactttgtta aaagaaggca aaaagcctac agtagcatct     1440

tggacaaaat attgggcagc tttgtgtggg acacagcttt tttactatgc tgccaaatct     1500

ctaaaggcta ccgaaagaaa acatttcaaa tcaacatcca ataagaacgt atctgtgata     1560

ggatggatgg tgatgatggc tgatgaccct gaacatcctg atctcttcct gctgactgac     1620

tctgagaaag gaaattcgta caagtttcaa gctggcaata gaatgaatgc aatgttatgg     1680

tttaagcatt tgagtgcagc ctgccaaagt aacaaacaac aggttcctac aaacttgatg     1740

acttttgagt ag                                                         1752


<210>  564
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Asp Leu Met Asn Gly Gln Ala Ser Ser Val Asn Ile Ala Ala Thr 
1               5                   10                  15      


Ala Ser Glu Lys Ser Ser Ser Ser Glu Ser Leu Ser Asp Lys Gly Ser 
            20                  25                  30          


Glu Leu Lys Lys Ser Phe Asp Ala Val Val Phe Asp Val Leu Lys Val 
        35                  40                  45              


Thr Pro Glu Glu Tyr Ala Gly Gln Ile Thr Leu Met Asp Val Pro Val 
    50                  55                  60                  


Phe Lys Ala Ile Gln Pro Asp Glu Leu Ser Ser Cys Gly Trp Asn Lys 
65                  70                  75                  80  


Lys Glu Lys Tyr Ser Ser Ala Pro Asn Ala Val Ala Phe Thr Arg Arg 
                85                  90                  95      


Phe Asn His Val Ser Phe Trp Val Val Arg Glu Ile Leu His Ala Gln 
            100                 105                 110         


Thr Leu Lys Ile Arg Ala Glu Val Leu Ser His Tyr Ile Lys Thr Ala 
        115                 120                 125             


Lys Lys Leu Tyr Glu Leu Asn Asn Leu His Ala Leu Met Ala Val Val 
    130                 135                 140                 


Ser Gly Leu Gln Ser Ala Pro Ile Phe Arg Leu Thr Lys Thr Trp Ala 
145                 150                 155                 160 


Leu Leu Ser Arg Lys Asp Lys Thr Thr Phe Glu Lys Leu Glu Tyr Val 
                165                 170                 175     


Met Ser Lys Glu Asp Asn Tyr Lys Arg Leu Arg Asp Tyr Ile Ser Ser 
            180                 185                 190         


Leu Lys Met Thr Pro Cys Ile Pro Tyr Leu Gly Ile Tyr Leu Ser Asp 
        195                 200                 205             


Leu Thr Tyr Ile Asp Ser Ala Tyr Pro Ser Thr Gly Ser Ile Leu Glu 
    210                 215                 220                 


Asn Glu Gln Arg Ser Asn Leu Met Asn Asn Ile Leu Arg Ile Ile Ser 
225                 230                 235                 240 


Asp Leu Gln Gln Ser Cys Glu Tyr Asp Ile Pro Met Leu Pro His Val 
                245                 250                 255     


Gln Lys Tyr Leu Asn Ser Val Gln Tyr Ile Glu Glu Leu Gln Lys Phe 
            260                 265                 270         


Val Glu Asp Asp Asn Tyr Lys Leu Ser Leu Lys Ile Glu Pro Gly Thr 
        275                 280                 285             


Ser Thr Pro Arg Ser Ala Ala Ser Arg Glu Asp Leu Val Gly Pro Glu 
    290                 295                 300                 


Val Gly Ala Ser Pro Gln Ser Gly Arg Lys Ser Val Ala Ala Glu Gly 
305                 310                 315                 320 


Ala Leu Leu Pro Gln Thr Pro Pro Ser Pro Arg Asn Leu Ile Pro His 
                325                 330                 335     


Gly His Arg Lys Cys His Ser Leu Gly Tyr Asn Phe Ile His Lys Met 
            340                 345                 350         


Asn Thr Ala Glu Phe Lys Ser Ala Thr Phe Pro Asn Ala Gly Pro Arg 
        355                 360                 365             


His Leu Leu Asp Asp Ser Val Met Glu Pro His Ala Pro Ser Arg Gly 
    370                 375                 380                 


Gln Ala Glu Ser Ser Thr Leu Ser Ser Gly Ile Ser Ile Gly Ser Ser 
385                 390                 395                 400 


Asp Gly Ser Glu Leu Ser Glu Glu Thr Ser Trp Pro Ala Phe Glu Arg 
                405                 410                 415     


Asn Arg Leu Tyr His Ser Leu Gly Pro Val Thr Arg Val Ala Arg Asn 
            420                 425                 430         


Gly Tyr Arg Ser His Met Lys Ala Ser Ser Ser Ala Glu Ser Glu Asp 
        435                 440                 445             


Leu Ala Val His Leu Tyr Pro Gly Ala Val Thr Ile Gln Gly Val Leu 
    450                 455                 460                 


Arg Arg Lys Thr Leu Leu Lys Glu Gly Lys Lys Pro Thr Val Ala Ser 
465                 470                 475                 480 


Trp Thr Lys Tyr Trp Ala Ala Leu Cys Gly Thr Gln Leu Phe Tyr Tyr 
                485                 490                 495     


Ala Ala Lys Ser Leu Lys Ala Thr Glu Arg Lys His Phe Lys Ser Thr 
            500                 505                 510         


Ser Asn Lys Asn Val Ser Val Ile Gly Trp Met Val Met Met Ala Asp 
        515                 520                 525             


Asp Pro Glu His Pro Asp Leu Phe Leu Leu Thr Asp Ser Glu Lys Gly 
    530                 535                 540                 


Asn Ser Tyr Lys Phe Gln Ala Gly Asn Arg Met Asn Ala Met Leu Trp 
545                 550                 555                 560 


Phe Lys His Leu Ser Ala Ala Cys Gln Ser Asn Lys Gln Gln Val Pro 
                565                 570                 575     


Thr Asn Leu Met Thr Phe Glu 
            580             


<210>  565
<211>  2917
<212>  DNA
<213>  Homo sapiens

<400>  565
atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggccct ggccctgacc       60

cagacctggg cgggtgagtg cggggtcggg agggaaacgg cctctgtggg gagaagcaag      120

gggcccgccc ggcgggggcg caggacccgg gaagccgcgc ctggaggagg gtcgggcggg      180

tctcagccac tcctcgcccc caggctccca ctccatgagg tatttctaca cttccgtgtc      240

ccggcccggc cgcggggagc cccgcttcat cgccgtgggc tacgtggacg acacgcagtt      300

cgtgcggttc gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga      360

gcaggagggg ccggagtatt gggaccggaa cacacggaat gtgaaggccc agtcacagac      420

tgaccgagtg gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggtgagtg      480

accccggccc ggggcgcagg tcacgacccc tcatccccca cggacgggcc aggtcgccca      540

cagtctccgg gtccgagatc cgccccgaag ccgcgggacc ccgagaccct tgccccggga      600

gaggcccagg cgcctttacc cggtttcatt ttcagtttag gccaaaaatc cccccgggtt      660

ggtcggggcg gggcggggct cgggggaccg ggctgacctc ggggtccggg ccaggttctc      720

acaccatcca gatgatgtat ggctgcgacg tggggtcgga cgggcgcttc ctccgcgggt      780

accggcagga cgcctacgac ggcaaggatt acatcgccct gaaagaggac ctgcgctctt      840

ggaccgcggc ggacatggca gctcagacca ccaagcacaa gtgggaggcg gcccatgtgg      900

cggagcagtg gagagcctac ctggagggca cgtgcgtgga gtggctccgc agatacctgg      960

agaacgggaa ggagacgctg cagcgcacgg gtaccagggg ccacggggcg cctccctgat     1020

cgcctgtaga tctcccgggc tggcctccca caaggagggg agacaattgg gaccaacact     1080

agaatatcgc cctccctctg gtcctgaggg agaggaatcc tcctgggttt ccagatcctg     1140

taccagagag tgactctgag gttccgccct gctctctgac acaattaagg gataaaatct     1200

ctgaaggaat gacgggaaga cgatccctcg aatactgatg agtggttccc tttgacacac     1260

acaggcagca gccttgggcc cgtgactttt cctctcaggc cttgttctct gcttcacact     1320

caatgtgtgt gggggtctga gtccagcact tctgagtccc tcagcctcca ctcaggtcag     1380

gaccagaagt cgctgttccc tcttcaggga ctagaatttt ccacggaata ggagattatc     1440

ccaggtgcct gtgtccaggc tggtgtctgg gttctgtgct cccttcccca tcccaggtgt     1500

cctgtccatt ctcaagatag ccacatgtgt gctggaggag tgtcccatga cagatgcaaa     1560

atgcctgaat gatctgactc ttcctgacag acgcccccaa aacgcatatg actcaccacg     1620

ctgtctctga ccatgaagcc accctgaggt gctgggccct gagcttctac cctgcggaga     1680

tcacactgac ctggcagcgg gatggggagg accagaccca ggacacggag ctcgtggaga     1740

ccaggcctgc aggggatgga accttccaga agtgggtggc tgtggtggtg ccttctggac     1800

aggagcagag atacacctgc catgtgcagc atgagggttt gcccaagccc ctcaccctga     1860

gatggggtaa ggagggagac gggggtgtca tgtcttttag ggaaagcagg agcctctctg     1920

acctttagca gggtcagggc ccctcacctt cccctctttt cccagagccg tcttcccagc     1980

ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct gtgatcactg     2040

gagctgtggt cgctgctgtg atgtggagga ggaagagctc aggtggggaa ggggtgaagg     2100

gtgggtctga gatttcttgt ctcactgagg gttccaagac ccaggtagaa gtgtgccctg     2160

cctcgttact gggaagcacc acccacaatt atgggcctac ccagcctggg ccctgtgtgc     2220

cagcacttac tcttttgtaa agcacctgtt aaaatgaagg acagatttat caccttgatt     2280

acagcggtga tgggacctga tcccagcagt cacaagtcac aggggaaggt ccctgaggac     2340

cttcaggagg gcggttggtc caggacccac acctgctttc ttcatgtttc ctgatcccgc     2400

cctgggtctg cagtcacaca tttctggaaa cttctctgag gtccaagact tggaggttcc     2460

tctaggacct taaggccctg actcctttct ggtatctcac aggacatttt cttcccacag     2520

atagaaaagg agggagctac tctcaggctg caagtaagta tgaaggaggc tgatgcctga     2580

ggtccttggg atattgtgtt tgggagccca tgggggagct cacccacccc acaattcctc     2640

ctctagccac atcttctgtg ggatctgacc aggttctgtt tttgttctac cccaggcagt     2700

gacagtgccc agggctctga tgtgtctctc acagcttgta aaggtgagag cctggagggc     2760

ctgatgtgtg ttgggtgttg ggcagaacag tggacacagc tgtgctatgg gggttctttc     2820

cattggatgt attgagcatg cgatgggctg tttaaagtgt gacccctcac tgtgacagat     2880

acgaatttgt tcatgaatat ttttttctat agtgtga                              2917


<210>  566
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Met Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Val Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  567
<211>  612
<212>  DNA
<213>  Homo sapiens

<400>  567
atgtcgtccg acttcgaagg ttacgagcag gacttcgcgg tgctcactgc agagatcacc       60

agcaagattg cgagggtccc acgactcccg cctgatgaaa agaaacagat ggttgcaaat      120

gtggagaaac agcttgaaga agcgaaagaa ctgcttgaac agatggattt ggaagtccga      180

gagataccac cccaaagtcg agggatgtac agcaacagaa tgagaagcta caaacaagaa      240

atgggaaaac tcgaaacaga ttttaaaagg tcacggatcg cctacagtga cgaagtacgg      300

aatgagctcc tgggggatga tgggaattcc tcagagaacc agagggcaca tctgctcgat      360

aacacagaga ggctggaaag gtcatctcgg agactagagg ctggatacca aatagcagtg      420

gaaaccgagc aaattggtca ggagatgttg gaaaacctta gtcatgacag agaaaagata      480

cagcgagcac gtgaaagact tcgggaaaca gatgctaatt tgggaaaaag ctccaggatt      540

ctgacaggga tgttgcgaag gggttgttct gtgaaaaaac aatgtaacct gtctctggcc      600

ccaaaggctt ga                                                          612


<210>  568
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr 
1               5                   10                  15      


Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp 
            20                  25                  30          


Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala 
        35                  40                  45              


Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro 
    50                  55                  60                  


Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu 
65                  70                  75                  80  


Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser 
                85                  90                  95      


Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu 
            100                 105                 110         


Asn Gln Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser 
        115                 120                 125             


Ser Arg Arg Leu Glu Ala Gly Tyr Gln Ile Ala Val Glu Thr Glu Gln 
    130                 135                 140                 


Ile Gly Gln Glu Met Leu Glu Asn Leu Ser His Asp Arg Glu Lys Ile 
145                 150                 155                 160 


Gln Arg Ala Arg Glu Arg Leu Arg Glu Thr Asp Ala Asn Leu Gly Lys 
                165                 170                 175     


Ser Ser Arg Ile Leu Thr Gly Met Leu Arg Arg Gly Cys Ser Val Lys 
            180                 185                 190         


Lys Gln Cys Asn Leu Ser Leu Ala Pro Lys Ala 
        195                 200             


<210>  569
<211>  1503
<212>  DNA
<213>  Homo sapiens

<400>  569
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tga                                                                   1503


<210>  570
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  571
<211>  1035
<212>  DNA
<213>  Homo sapiens

<400>  571
atgtcggggg agcctgagct cattgagctg cgggagctgg cacccgctgg gcgcgctggg       60

aagggccgca cccggctgga gcgtgccaac gcgctgcgca tcgcgcgggg caccgcgtgc      120

aaccccacac ggcagctggt ccctggccgt ggccaccgct tccagcccgc ggggcccgcc      180

acgcacacgt ggtgcgacct ctgtggcgac ttcatctggg gcgtcgtgcg caaaggcctg      240

cagtgcgcgc gcctctctgc agattgcaag ttcacctgcc actaccgctg ccgcgcgctc      300

gtctgcctgg actgttgcgg gccccgggac ctgggctggg aacccgcggt ggagcgggac      360

acgaacgtgg acgagcctgt ggagtgggag acacctgacc tttctcaagc tgagattgag      420

cagaagatca aggagtacaa tgcccagatc aacagcaacc tcttcatgag cttgaacaag      480

gacggttctt acacaggctt catcaaggtt cagctgaagc tggtgcgccc tgtctctgtg      540

ccctccagca agaagccacc ctccttgcag gatgcccggc ggggcccagg acggggcaca      600

agtgtcaggc gccgcacttc cttttacctg cccaaggatg ctgtcaagca cctgcatgtg      660

ctgtcacgca caagggcacg tgaagtcatt gaggccctgc tgcgaaagtt cttggtggtg      720

gatgaccccc gcaagtttgc actctttgag cgcgctgagc gtcacggcca agtgtacttg      780

cggaagctgt tggatgatga gcagcccctg cggctgcggc tcctggcagg gcccagtgac      840

aaggccctga gctttgtcct gaaggaaaat gactctgggg aggtgaactg ggacgccttc      900

agcatgcctg aactacataa cttcctacgt atcctgcagc gggaggagga ggagcacctc      960

cgccagatcc tgcagaagta ctcctattgc cgccagaaga tccaagaggc cctgcacgcc     1020

tgcccccttg ggtga                                                      1035


<210>  572
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Ser Gly Glu Pro Glu Leu Ile Glu Leu Arg Glu Leu Ala Pro Ala 
1               5                   10                  15      


Gly Arg Ala Gly Lys Gly Arg Thr Arg Leu Glu Arg Ala Asn Ala Leu 
            20                  25                  30          


Arg Ile Ala Arg Gly Thr Ala Cys Asn Pro Thr Arg Gln Leu Val Pro 
        35                  40                  45              


Gly Arg Gly His Arg Phe Gln Pro Ala Gly Pro Ala Thr His Thr Trp 
    50                  55                  60                  


Cys Asp Leu Cys Gly Asp Phe Ile Trp Gly Val Val Arg Lys Gly Leu 
65                  70                  75                  80  


Gln Cys Ala Arg Leu Ser Ala Asp Cys Lys Phe Thr Cys His Tyr Arg 
                85                  90                  95      


Cys Arg Ala Leu Val Cys Leu Asp Cys Cys Gly Pro Arg Asp Leu Gly 
            100                 105                 110         


Trp Glu Pro Ala Val Glu Arg Asp Thr Asn Val Asp Glu Pro Val Glu 
        115                 120                 125             


Trp Glu Thr Pro Asp Leu Ser Gln Ala Glu Ile Glu Gln Lys Ile Lys 
    130                 135                 140                 


Glu Tyr Asn Ala Gln Ile Asn Ser Asn Leu Phe Met Ser Leu Asn Lys 
145                 150                 155                 160 


Asp Gly Ser Tyr Thr Gly Phe Ile Lys Val Gln Leu Lys Leu Val Arg 
                165                 170                 175     


Pro Val Ser Val Pro Ser Ser Lys Lys Pro Pro Ser Leu Gln Asp Ala 
            180                 185                 190         


Arg Arg Gly Pro Gly Arg Gly Thr Ser Val Arg Arg Arg Thr Ser Phe 
        195                 200                 205             


Tyr Leu Pro Lys Asp Ala Val Lys His Leu His Val Leu Ser Arg Thr 
    210                 215                 220                 


Arg Ala Arg Glu Val Ile Glu Ala Leu Leu Arg Lys Phe Leu Val Val 
225                 230                 235                 240 


Asp Asp Pro Arg Lys Phe Ala Leu Phe Glu Arg Ala Glu Arg His Gly 
                245                 250                 255     


Gln Val Tyr Leu Arg Lys Leu Leu Asp Asp Glu Gln Pro Leu Arg Leu 
            260                 265                 270         


Arg Leu Leu Ala Gly Pro Ser Asp Lys Ala Leu Ser Phe Val Leu Lys 
        275                 280                 285             


Glu Asn Asp Ser Gly Glu Val Asn Trp Asp Ala Phe Ser Met Pro Glu 
    290                 295                 300                 


Leu His Asn Phe Leu Arg Ile Leu Gln Arg Glu Glu Glu Glu His Leu 
305                 310                 315                 320 


Arg Gln Ile Leu Gln Lys Tyr Ser Tyr Cys Arg Gln Lys Ile Gln Glu 
                325                 330                 335     


Ala Leu His Ala Cys Pro Leu Gly 
            340                 


<210>  573
<211>  1206
<212>  DNA
<213>  Homo sapiens

<400>  573
atgatgggct tgggaaacgg gcgtcgcagc atgaagtcgc cgcccctcgt gctggccgcc       60

ctggtggcct gcatcatcgt cttgggcttc aactactgga ttgcgagctc ccggagcgtg      120

gacctccaga cacggatcat ggagctggaa ggcagggtcc gcagggcggc tgcagagaga      180

ggcgccgtgg agctgaagaa gaacgagttc cagggagagc tggagaagca gcgggagcag      240

cttgacaaaa tccagtccag ccacaacttc cagctggaga gcgtcaacaa gctgtaccag      300

gacgaaaagg cggttttggt gaataacatc accacaggtg agaggctcat ccgagtgctg      360

caagaccagt taaagaccct gcagaggaat tacggcaggc tgcagcagga tgtcctccag      420

tttcagaaga accagaccaa cctggagagg aagttctcct acgacctgag ccagtgcatc      480

aatcagatga aggaggtgaa ggaacagtgt gaggagcgaa tagaagaggt caccaaaaag      540

gggaatgaag ctgtagcttc cagagacctg agtgaaaaca acgaccagag acagcagctc      600

caagccctca gtgagcctca gcccaggctg caggcagcag gcctgccaca cacagaggtg      660

ccacaaggga agggaaacgt gcttggtaac agcaagtccc agacaccagc ccccagttcc      720

gaagtggttt tggattcaaa gagacaagtt gagaaagagg aaaccaatga gatccaggtg      780

gtgaatgagg agcctcagag ggacaggctg ccgcaggagc caggccggga gcaggtggtg      840

gaagacagac ctgtaggtgg aagaggcttc gggggagccg gagaactggg ccagacccca      900

caggtgcagg ctgccctgtc agtgagccag gaaaatccag agatggaggg ccctgagcga      960

gaccagcttg tcatccccga cggacaggag gaggagcagg aagctgccgg ggaagggaga     1020

aaccagcaga aactgagagg agaagatgac tacaacatgg atgaaaatga agcagaatct     1080

gagacagaca agcaagcagc cctggcaggg aatgacagaa acatagatgt ttttaatgtt     1140

gaagatcaga aaagagacac cataaattta cttgatcagc gtgaaaagcg gaatcataca     1200

ctctga                                                                1206


<210>  574
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  575
<211>  2712
<212>  DNA
<213>  Homo sapiens

<400>  575
atggcaatcc agttccgttc gctcttcccc ttggcattgc ctgggatgct ggcgctcctc       60

ggctggtggt ggtttttctc tcgtaaaaaa ggccatgtca gcagccatga tgagcagcag      120

gtggaggctg gtgctgtgca gctgagggct gaccctgcca tcaaggaacc tctccccgtg      180

gaagacgtct gtcccaaagt agtgtccaca ccccccagtg tcacagagcc tccagaaaag      240

gaactgtcca ccgtgagcaa gctgcctgca gagcccccag cattgctcca gacacaccca      300

ccttgccgaa gatcagagtc ctcgggcatt cttcctaaca ccacagacat gagattgcga      360

ccaggaacac gcagagatga cagtacaaag ctggagctag ccctgacagg tggtgaagcc      420

aaatcgattc ctctagagtg ccccctttca tccccaaagg gtgtactatt ctccagcaaa      480

tcagctgagg tgtgtaagca agattccccc ttcagcaggg tgccaaggaa ggtccagcca      540

ggctaccccg tagtccccgc agagaagcgt agctctgggg agagggcaag agagacaggt      600

ggggccgaag ggactggtga tgccgtgttg ggggaaaagg tgcttgaaga agctctgttg      660

tctcgggagc atgtcttgga attggagaac agcaagggcc ccagcctggc ctctttagag      720

ggggaagaag ataaggggaa gagcagctca tcccaggtgg tggggccagt gcaggaggaa      780

gagtatgtag cagagaagtt gccaagtagg ttcatcgagt cggctcacac agagctggca      840

aaggacgatg cggcgccagc acccccagtc gcagacgcca aagcccagga tagaggtgtc      900

gagggagaac tgggcaatga ggagagcttg gatagaaatg aggagggctt ggatagaaat      960

gaggagggct tggatagaaa tgaggagagc ttggatagaa atgaggaggg cttggataga     1020

aatgaggaga ttaagcgggc tgccttccag ataatctccc aagtgatctc agaagcaacc     1080

gaacaggtgc tggccaccac ggttggcaag gttgcaggtc gtgtgtgtca ggccagtcag     1140

ctccaagggc agaaggaaga gagctgtgtc ccagttcacc agaaaactgt cttgggccca     1200

gacactgcgg agcctgccac agcagaggca gctgttgccc cgccggatgc tggcctcccc     1260

ttgccaggcc taccagcaga gggctcacca ccaccaaaga cctacgtgag ctgcctgaag     1320

agccttctgt ccagccccac caaggacagt aagccaaata tctctgcaca ccacatctcc     1380

ctggcctcct gcctggcact gaccaccccc agtgaagagt tgccggaccg ggcaggcatc     1440

ctggtggaag atgccacctg tgtcacctgc atgtcagaca gcagccaaag tgtccctttg     1500

gtggcttctc caggacactg ctcagattct ttcagcactt cagggcttga agactcttgc     1560

acagagacca gctcgagccc cagggacaag gccatcaccc cgccactgcc agaaagtact     1620

gtgcccttca gcaatggggt gctgaagggg gagttgtcag acttgggggc tgaggatgga     1680

tggaccatgg atgcggaagc agatcattca ggaggttctg acaggaacag catggattcc     1740

gtggatagct gttgcagtct caagaagact gagagcttcc aaaatgccca ggcaggctcc     1800

aaccctaaga aggtcgacct catcatctgg gagatcgagg tgccaaagca cttagtcggt     1860

cggctaattg gcaagcaggg gcgctatgtg agttttctga agcaaacatc tggtgccaag     1920

atctacattt caaccctgcc ttacacccag agcgtccaga tctgccacat agaaggctct     1980

caacatcatg tagacaaagc gctgaacttg attgggaaga agttcaaaga gctgaacctc     2040

accaatatct acgctccccc attgccttca ctggcactgc cttctctgcc gatgacatcc     2100

tggctcatgc tgcctgatgg catcaccgtg gaggtcattg tggtcaacca ggtcaatgcc     2160

gggcacctgt tcgtgcagca gcacacacac cctaccttcc acgcgctgcg cagcctcgac     2220

cagcagatgt acctctgtta ctctcagcct ggaatcccca ccttgcccac cccagtggaa     2280

ataacggtca tctgtgccgc ccctggtgcg gacggggcct ggtggcgagc ccaagtggtt     2340

gcctcctacg aggagaccaa cgaagtggag attcgatacg tggactacgg cggatataag     2400

agggtgaaag tagacgtgct ccggcaaatc aggtctgact ttgtcaccct gccgtttcag     2460

ggagcagaag tccttctgga cagtgtgatg cccctgtcag acgatgacca gttttcaccg     2520

gaagcagatg ccgccatgag cgagatgacg gggaatacag cactgcttgc tcaggtgaca     2580

agttacagtc caactggtct tcctctgatt cagctgtgga gtgtggttgg agatgaagtg     2640

gtgttgataa accggtccct ggtggagcga ggccttgccc agtgggtaga cagctactac     2700

acaagccttt ga                                                         2712


<210>  576
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Thr Pro Pro Ser Val Thr Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Thr Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Thr His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Thr Thr Asp Met Arg Leu Arg Pro Gly Thr Arg Arg Asp Asp Ser 
        115                 120                 125             


Thr Lys Leu Glu Leu Ala Leu Thr Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Thr Gly Gly Ala Glu Gly Thr Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Thr Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Thr Glu Gln Val Leu Ala Thr Thr Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Thr Val Leu Gly Pro 
385                 390                 395                 400 


Asp Thr Ala Glu Pro Ala Thr Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Thr Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Thr Thr Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Thr Cys Val Thr Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Thr Ser Gly Leu Glu Asp Ser Cys Thr Glu Thr Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Thr Pro Pro Leu Pro Glu Ser Thr Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Thr Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                565                 570                 575     


Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Thr Glu Ser 
            580                 585                 590         


Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
        595                 600                 605             


Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
    610                 615                 620                 


Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys 
625                 630                 635                 640 


Ile Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Ser Val Gln Ile Cys His 
                645                 650                 655     


Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
            660                 665                 670         


Lys Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu 
        675                 680                 685             


Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu 
    690                 695                 700                 


Pro Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
705                 710                 715                 720 


Gly His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu 
                725                 730                 735     


Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
            740                 745                 750         


Pro Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro 
        755                 760                 765             


Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
    770                 775                 780                 


Glu Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
785                 790                 795                 800 


Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr 
                805                 810                 815     


Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
            820                 825                 830         


Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
        835                 840                 845             


Met Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Pro 
    850                 855                 860                 


Thr Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
865                 870                 875                 880 


Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                885                 890                 895     


Asp Ser Tyr Tyr Thr Ser Leu 
            900             


<210>  577
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  577
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ctatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acga                                             324


<210>  578
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  578

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  579
<211>  1053
<212>  DNA
<213>  Homo sapiens

<400>  579
atggaaccaa agcggatcag agagggctac cttgtgaaga aggggagcgt gttcaatacg       60

tggaaaccca tgtgggttgt attgttagaa gatggaattg aattctataa gaagaaaagt      120

gacaacagcc ccaaaggaat gatcccgctg aaagggagca ctctgactag cccttgtcaa      180

gactttggca aaaggatgtt tgtgtttaag atcactacga ccaaacagca ggaccacttc      240

ttccaggcag ccttcctgga ggagagagat gcctgggttc gggatatcaa gaaggccatt      300

aaatgcattg aaggaggcca gaaatttgcc aggaaatcta ccaggaggtc cattcgactg      360

ccagaaacca ttgacttagg tgccttatat ttgtccatga aagacactga aaaaggaata      420

aaagaactga atctagagaa ggacaagaag atttttaatc actgcttcac aggtaactgc      480

gtcattgatt ggctggtatc caaccagtct gttaggaatc gccaggaagg cctcatgatt      540

gcttcatcgc tgctcaatga ggggtatctg cagcctgctg gagacatgtc caagagtgca      600

gtggatggaa ctgctgaaaa ccctttcctg gacaaccctg atgccttcta ctactttcca      660

gacagtgggt tcttctgtga agagaattcc agtgatgatg atgtgattct gaaagaagaa      720

ttcagagggg tcattatcaa gcagggatgt ttactgaagc aggggcatag aaggaaaaac      780

tggaaagtga ggaagttcat cttgagagaa gaccctgcct acctgcacta ctatgaccct      840

gctggggcag aagatcccct gggagcaatt cacttgagag gctgtgtggt gacttcagtg      900

gagagcaact caaatggcag gaagagtgag gaagagaacc tttttgagat catcacagca      960

gatgaagtgc actatttctt gcaagcagcc acccccaagg agcgcacaga gtggatcaga     1020

gccatccaga tggcctcccg aactgggaag taa                                  1053


<210>  580
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Glu Pro Lys Arg Ile Arg Glu Gly Tyr Leu Val Lys Lys Gly Ser 
1               5                   10                  15      


Val Phe Asn Thr Trp Lys Pro Met Trp Val Val Leu Leu Glu Asp Gly 
            20                  25                  30          


Ile Glu Phe Tyr Lys Lys Lys Ser Asp Asn Ser Pro Lys Gly Met Ile 
        35                  40                  45              


Pro Leu Lys Gly Ser Thr Leu Thr Ser Pro Cys Gln Asp Phe Gly Lys 
    50                  55                  60                  


Arg Met Phe Val Phe Lys Ile Thr Thr Thr Lys Gln Gln Asp His Phe 
65                  70                  75                  80  


Phe Gln Ala Ala Phe Leu Glu Glu Arg Asp Ala Trp Val Arg Asp Ile 
                85                  90                  95      


Lys Lys Ala Ile Lys Cys Ile Glu Gly Gly Gln Lys Phe Ala Arg Lys 
            100                 105                 110         


Ser Thr Arg Arg Ser Ile Arg Leu Pro Glu Thr Ile Asp Leu Gly Ala 
        115                 120                 125             


Leu Tyr Leu Ser Met Lys Asp Thr Glu Lys Gly Ile Lys Glu Leu Asn 
    130                 135                 140                 


Leu Glu Lys Asp Lys Lys Ile Phe Asn His Cys Phe Thr Gly Asn Cys 
145                 150                 155                 160 


Val Ile Asp Trp Leu Val Ser Asn Gln Ser Val Arg Asn Arg Gln Glu 
                165                 170                 175     


Gly Leu Met Ile Ala Ser Ser Leu Leu Asn Glu Gly Tyr Leu Gln Pro 
            180                 185                 190         


Ala Gly Asp Met Ser Lys Ser Ala Val Asp Gly Thr Ala Glu Asn Pro 
        195                 200                 205             


Phe Leu Asp Asn Pro Asp Ala Phe Tyr Tyr Phe Pro Asp Ser Gly Phe 
    210                 215                 220                 


Phe Cys Glu Glu Asn Ser Ser Asp Asp Asp Val Ile Leu Lys Glu Glu 
225                 230                 235                 240 


Phe Arg Gly Val Ile Ile Lys Gln Gly Cys Leu Leu Lys Gln Gly His 
                245                 250                 255     


Arg Arg Lys Asn Trp Lys Val Arg Lys Phe Ile Leu Arg Glu Asp Pro 
            260                 265                 270         


Ala Tyr Leu His Tyr Tyr Asp Pro Ala Gly Ala Glu Asp Pro Leu Gly 
        275                 280                 285             


Ala Ile His Leu Arg Gly Cys Val Val Thr Ser Val Glu Ser Asn Ser 
    290                 295                 300                 


Asn Gly Arg Lys Ser Glu Glu Glu Asn Leu Phe Glu Ile Ile Thr Ala 
305                 310                 315                 320 


Asp Glu Val His Tyr Phe Leu Gln Ala Ala Thr Pro Lys Glu Arg Thr 
                325                 330                 335     


Glu Trp Ile Arg Ala Ile Gln Met Ala Ser Arg Thr Gly Lys 
            340                 345                 350 


<210>  581
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  581
gcttccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag aagtccaaat      300

atggtccccc atgcccatca tgcccagcct gagttcctgg ggggaccatc agtcttcctg      360

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      420

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      480

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      540

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      600

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag      660

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag      720

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag      780

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc      840

tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc      900

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc      960

ctgtctctgg ctgcaactgg aggagagctg tgcggaggcg caggacgggg agctggacgg     1020

gctgtggacg accatcacca tcttcatcac actcttcctg ctaagcgtgt gctacagtgc     1080

caccgtcacc ttcttcaagt gaagtggatc ttctcctcag tggtggacct gaagcagacc     1140

atcgtccccg actacaggaa catgataagg cagggggcct ag                        1182


<210>  582
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  582

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Ser Pro Asn Met Val Pro His Ala His His Ala Gln Pro Glu Phe 
            100                 105                 110         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        195                 200                 205             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Leu Ala Ala Thr Gly Gly Glu Leu Cys Gly Gly Ala Gly Arg 
                325                 330                 335     


Gly Ala Gly Arg Ala Val Asp Asp His His His Leu His His Thr Leu 
            340                 345                 350         


Pro Ala Lys Arg Val Leu Gln Cys His Arg His Leu Leu Gln Val Lys 
        355                 360                 365             


Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp 
    370                 375                 380                 


Tyr Arg Asn Met Ile Arg Gln Gly Ala 
385                 390             


<210>  583
<211>  2051
<212>  DNA
<213>  Homo sapiens

<400>  583
gcgatcgctt tcgaaggaga tagaaccatg gtaaagaagc ggaaaggccg cgtcgtgatc       60

gactcggaca cagaggacag cggcagcgac gagaacctgg atcaggagct cttgtccctg      120

gcaaagcgaa agcgcagtga ctctgaggag aaggagccgc ctgtgagtca gcctgcagcc      180

tcgtcagact cggagacgtc tgacagtgac gatgagtgga catttgggag caataaaaat      240

aagaagaaag gaaaagccag aaaaatagag aagaaaggaa ccatgaagaa acaggccaac      300

aaaactgcct cctcaggcag ttcagacaaa gacagttcag ctgagagctc agcccctgag      360

gaaggtgaag tgtcagactc tgacagcaac agctcctctt ccagttcaga ttcagactct      420

tcctcagaag atgaagagtt ccatgatggc tatggagaag acctcatggg agatgaggaa      480

gacagggccc gtctggaaca gatgacagag aaagagagag agcaagaact gttcaatcgc      540

atagagaaga gggaggtgtt gaaaagaaga tttgaaatca agaaaaaact aaaaacagcc      600

aaaaagaaag aaaagaaaga aaagaagaaa aagcaagaag aggagcaaga aaagaaaaaa      660

ctgacacaga ttcaagaatc tcaggtaaca tcccacaaca aggaacggcg ttccaagcgg      720

gatgagaaac tagacaagaa atctcaagcc atggaggagc taaaagcaga gcgagaaaaa      780

cgaaagaaca gaacagctga gctccttgcc aaaaaacagc cattaaaaac cagtgaggtc      840

tactctgatg atgaagagga ggaagaggat gacaaatcca gtgaaaagtc agaccgctca      900

tcacgaacat catcgtctga tgaagaagag gagaaagaag agatccctcc caaatcccaa      960

ccagtttcct tacctgaaga attgaatcgg gttcgattat cacggcataa gctagaacgc     1020

tggtgtcaca tgcccttctt tgctaaaact gtcacaggat gttttgtgcg gattggcatc     1080

ggaaaccaca acagcaaacc agtttaccgg gtcgctgaga ttacgggtgt tgtggaaact     1140

gccaaagttt accaactagg tggcaccaga acaaacaaag ggctgcaact acggcatggc     1200

aatgaccaac gcgtgttccg tttagagttt gtctcaaacc aagaattcac cgaaagtgag     1260

tttatgaagt ggaaagaagc gatgttctct gctggcatgc agttgcccac tctagatgaa     1320

atcaataaaa aggaattatc tattaaagaa gctcttaatt ataaattcaa tgatcaggac     1380

attgaagaga ttgtaaaaga gaaagaaagg ttcagaaaag ctccacccaa ctacgctatg     1440

aagaagactc agctactgaa ggaaaaggcc atggctgagg acctggggga tcaggacaag     1500

gccaaacaaa tccaagatca actgaatgag ctggaggaac gggcagaggc cctggaccgc     1560

cagcggacca agaacatatc cgctatcagt tacatcaacc agcggaaccg ggagtggaac     1620

attgtagagt ctgagaaggc ccttgtggct gaaagtcaca acatgaaaaa ccaacagatg     1680

gatcccttta ctcggcggca gtgcaagcct accatcgttt ctaattccag agacccagct     1740

gttcaagctg ccatcttggc ccagctgaat gcaaaatacg gttctggagt gttaccagat     1800

gctccaaagg aaatgagcaa gggtcaaggc aaagataaag atttgaattc taagtcagcc     1860

agtgacctct cagaagatct gttcaaagta cacgattttg atgtgaagat tgacttacaa     1920

gttcccagct cagagtcaaa ggctttagcc atcacctcca aggctccgcc agccaaggat     1980

ggggctccaa ggagatctct gaacttggaa gactacaaaa aacgacgagg gcttatttac     2040

gtagtttaaa c                                                          2051


<210>  584
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Val Lys Lys Arg Lys Gly Arg Val Val Ile Asp Ser Asp Thr Glu 
1               5                   10                  15      


Asp Ser Gly Ser Asp Glu Asn Leu Asp Gln Glu Leu Leu Ser Leu Ala 
            20                  25                  30          


Lys Arg Lys Arg Ser Asp Ser Glu Glu Lys Glu Pro Pro Val Ser Gln 
        35                  40                  45              


Pro Ala Ala Ser Ser Asp Ser Glu Thr Ser Asp Ser Asp Asp Glu Trp 
    50                  55                  60                  


Thr Phe Gly Ser Asn Lys Asn Lys Lys Lys Gly Lys Ala Arg Lys Ile 
65                  70                  75                  80  


Glu Lys Lys Gly Thr Met Lys Lys Gln Ala Asn Lys Thr Ala Ser Ser 
                85                  90                  95      


Gly Ser Ser Asp Lys Asp Ser Ser Ala Glu Ser Ser Ala Pro Glu Glu 
            100                 105                 110         


Gly Glu Val Ser Asp Ser Asp Ser Asn Ser Ser Ser Ser Ser Ser Asp 
        115                 120                 125             


Ser Asp Ser Ser Ser Glu Asp Glu Glu Phe His Asp Gly Tyr Gly Glu 
    130                 135                 140                 


Asp Leu Met Gly Asp Glu Glu Asp Arg Ala Arg Leu Glu Gln Met Thr 
145                 150                 155                 160 


Glu Lys Glu Arg Glu Gln Glu Leu Phe Asn Arg Ile Glu Lys Arg Glu 
                165                 170                 175     


Val Leu Lys Arg Arg Phe Glu Ile Lys Lys Lys Leu Lys Thr Ala Lys 
            180                 185                 190         


Lys Lys Glu Lys Lys Glu Lys Lys Lys Lys Gln Glu Glu Glu Gln Glu 
        195                 200                 205             


Lys Lys Lys Leu Thr Gln Ile Gln Glu Ser Gln Val Thr Ser His Asn 
    210                 215                 220                 


Lys Glu Arg Arg Ser Lys Arg Asp Glu Lys Leu Asp Lys Lys Ser Gln 
225                 230                 235                 240 


Ala Met Glu Glu Leu Lys Ala Glu Arg Glu Lys Arg Lys Asn Arg Thr 
                245                 250                 255     


Ala Glu Leu Leu Ala Lys Lys Gln Pro Leu Lys Thr Ser Glu Val Tyr 
            260                 265                 270         


Ser Asp Asp Glu Glu Glu Glu Glu Asp Asp Lys Ser Ser Glu Lys Ser 
        275                 280                 285             


Asp Arg Ser Ser Arg Thr Ser Ser Ser Asp Glu Glu Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ile Pro Pro Lys Ser Gln Pro Val Ser Leu Pro Glu Glu Leu Asn 
305                 310                 315                 320 


Arg Val Arg Leu Ser Arg His Lys Leu Glu Arg Trp Cys His Met Pro 
                325                 330                 335     


Phe Phe Ala Lys Thr Val Thr Gly Cys Phe Val Arg Ile Gly Ile Gly 
            340                 345                 350         


Asn His Asn Ser Lys Pro Val Tyr Arg Val Ala Glu Ile Thr Gly Val 
        355                 360                 365             


Val Glu Thr Ala Lys Val Tyr Gln Leu Gly Gly Thr Arg Thr Asn Lys 
    370                 375                 380                 


Gly Leu Gln Leu Arg His Gly Asn Asp Gln Arg Val Phe Arg Leu Glu 
385                 390                 395                 400 


Phe Val Ser Asn Gln Glu Phe Thr Glu Ser Glu Phe Met Lys Trp Lys 
                405                 410                 415     


Glu Ala Met Phe Ser Ala Gly Met Gln Leu Pro Thr Leu Asp Glu Ile 
            420                 425                 430         


Asn Lys Lys Glu Leu Ser Ile Lys Glu Ala Leu Asn Tyr Lys Phe Asn 
        435                 440                 445             


Asp Gln Asp Ile Glu Glu Ile Val Lys Glu Lys Glu Arg Phe Arg Lys 
    450                 455                 460                 


Ala Pro Pro Asn Tyr Ala Met Lys Lys Thr Gln Leu Leu Lys Glu Lys 
465                 470                 475                 480 


Ala Met Ala Glu Asp Leu Gly Asp Gln Asp Lys Ala Lys Gln Ile Gln 
                485                 490                 495     


Asp Gln Leu Asn Glu Leu Glu Glu Arg Ala Glu Ala Leu Asp Arg Gln 
            500                 505                 510         


Arg Thr Lys Asn Ile Ser Ala Ile Ser Tyr Ile Asn Gln Arg Asn Arg 
        515                 520                 525             


Glu Trp Asn Ile Val Glu Ser Glu Lys Ala Leu Val Ala Glu Ser His 
    530                 535                 540                 


Asn Met Lys Asn Gln Gln Met Asp Pro Phe Thr Arg Arg Gln Cys Lys 
545                 550                 555                 560 


Pro Thr Ile Val Ser Asn Ser Arg Asp Pro Ala Val Gln Ala Ala Ile 
                565                 570                 575     


Leu Ala Gln Leu Asn Ala Lys Tyr Gly Ser Gly Val Leu Pro Asp Ala 
            580                 585                 590         


Pro Lys Glu Met Ser Lys Gly Gln Gly Lys Asp Lys Asp Leu Asn Ser 
        595                 600                 605             


Lys Ser Ala Ser Asp Leu Ser Glu Asp Leu Phe Lys Val His Asp Phe 
    610                 615                 620                 


Asp Val Lys Ile Asp Leu Gln Val Pro Ser Ser Glu Ser Lys Ala Leu 
625                 630                 635                 640 


Ala Ile Thr Ser Lys Ala Pro Pro Ala Lys Asp Gly Ala Pro Arg Arg 
                645                 650                 655     


Ser Leu Asn Leu Glu Asp Tyr Lys Lys Arg Arg Gly Leu Ile 
            660                 665                 670 


<210>  585
<211>  1749
<212>  DNA
<213>  Homo sapiens

<400>  585
atgatgaact tcctgcggcg ccggctgtcg gacagcagct tcatcgccaa cctgcccaac       60

ggctacatga ccgacctgca gcggcccgag ccccagcagc cgccgccgcc gccgcccccc      120

ggtccgggcg ccgcctcggc ctcggcggcg cccccgaccg cctcgccggg cccggagcgg      180

aagccgccgc ccgcctcggc gcccgcgccg cagcccgcgc cgacgccgtc ggtgggcagc      240

agcttcttca gctcgctgtc ccaagccgtg aagcagacgg ccgcctcggc tggcctggtg      300

gacgcgcccg ctcccgcgcc cgcagccgcc aggaaggcca aggtgctgct ggtggtcgac      360

gagccgcacg ccgactgggc caagtgcttt cggggcaaaa aagtccttgg agattatgat      420

atcaaggtgg aacaggcaga attttcagag ctcaacctgg tggcccatgc agatggcacc      480

tatgctgtgg atatgcaggt tctccggaat ggcacaaagg ttgtccggtc cttccggcca      540

gacttcgtgc tcatccggca gcatgcattt ggcatggcgg agaatgagga cttccgccac      600

ctgatcattg gtatgcagta tgcaggcctc cccagcatca actcactgga atccatatac      660

aacttctgtg acaagccatg ggtgtttgcc cagctggtcg ctatctataa gacactggga      720

ggagaaaagt tccctctcat tgaacagaca tactacccca accacaaaga gatgctgaca      780

ctgcccacgt tccctgtggt ggtgaagatt ggccacgctc actcaggcat gggcaaggtc      840

aaagtggaaa accactacga cttccaggac attgccagcg tggtggctct cacccagacc      900

tatgccactg cagagccttt cattgactcc aagtatgaca tccgggtcca gaagattggc      960

aacaactaca aggcttacat gaggacatcg atctcaggga actggaagac gaacactggc     1020

tctgcgatgc tggagcagat tgccatgtca gacaggtaca aactgtgggt ggacacctgc     1080

tctgagatgt ttggcggcct ggacatctgt gctgtcaaag ctgtacatgg caaagatggg     1140

aaagactaca tttttgaggt catggactgt agcatgccac tgattgggga acatcaggtg     1200

gaggacaggc aactcatcac cgaattagtc atcagcaaga tgaaccagct gctgtccagg     1260

actcctgccc tgtctcctca gagaccccta acaacccagc agccacagag cggaacactt     1320

aaggatccgg actcaagcaa gaccccacct cagcggccac cccctcaagg gggccctggg     1380

caaccccaag gaatgcagcc cccaggcaag gtgctgcctc cacgccggct cccccctgga     1440

ccatcactgc caccttcctc ctcttcctcc tcttcttcct cctcctcggc tcctcagcgg     1500

ccgggcggcc ccaccaccca cggagatgca ccctccagca gcagctccct ggcagaggcc     1560

cagccacccc tggctgctcc accacagaag ccccagcctc acccacagct caacaagtcg     1620

cagtccctga caaatgcctt cagcttctct gagtcctcct tcttccggtc ttcagccaat     1680

gaggatgaag ccaaagcgga gaccatccgg agcttgagga agtcctttgc cagcctcttt     1740

tcagattag                                                             1749


<210>  586
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  586

Met Met Asn Phe Leu Arg Arg Arg Leu Ser Asp Ser Ser Phe Ile Ala 
1               5                   10                  15      


Asn Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Glu Pro Gln 
            20                  25                  30          


Gln Pro Pro Pro Pro Pro Pro Pro Gly Pro Gly Ala Ala Ser Ala Ser 
        35                  40                  45              


Ala Ala Pro Pro Thr Ala Ser Pro Gly Pro Glu Arg Lys Pro Pro Pro 
    50                  55                  60                  


Ala Ser Ala Pro Ala Pro Gln Pro Ala Pro Thr Pro Ser Val Gly Ser 
65                  70                  75                  80  


Ser Phe Phe Ser Ser Leu Ser Gln Ala Val Lys Gln Thr Ala Ala Ser 
                85                  90                  95      


Ala Gly Leu Val Asp Ala Pro Ala Pro Ala Pro Ala Ala Ala Arg Lys 
            100                 105                 110         


Ala Lys Val Leu Leu Val Val Asp Glu Pro His Ala Asp Trp Ala Lys 
        115                 120                 125             


Cys Phe Arg Gly Lys Lys Val Leu Gly Asp Tyr Asp Ile Lys Val Glu 
    130                 135                 140                 


Gln Ala Glu Phe Ser Glu Leu Asn Leu Val Ala His Ala Asp Gly Thr 
145                 150                 155                 160 


Tyr Ala Val Asp Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg 
                165                 170                 175     


Ser Phe Arg Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met 
            180                 185                 190         


Ala Glu Asn Glu Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala 
        195                 200                 205             


Gly Leu Pro Ser Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp 
    210                 215                 220                 


Lys Pro Trp Val Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly 
225                 230                 235                 240 


Gly Glu Lys Phe Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys 
                245                 250                 255     


Glu Met Leu Thr Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His 
            260                 265                 270         


Ala His Ser Gly Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe 
        275                 280                 285             


Gln Asp Ile Ala Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala 
    290                 295                 300                 


Glu Pro Phe Ile Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly 
305                 310                 315                 320 


Asn Asn Tyr Lys Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys 
                325                 330                 335     


Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
            340                 345                 350         


Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp 
        355                 360                 365             


Ile Cys Ala Val Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile 
    370                 375                 380                 


Phe Glu Val Met Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val 
385                 390                 395                 400 


Glu Asp Arg Gln Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln 
                405                 410                 415     


Leu Leu Ser Arg Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr 
            420                 425                 430         


Gln Gln Pro Gln Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr 
        435                 440                 445             


Pro Pro Gln Arg Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly 
    450                 455                 460                 


Met Gln Pro Pro Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly 
465                 470                 475                 480 


Pro Ser Leu Pro Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                485                 490                 495     


Ala Pro Gln Arg Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser 
            500                 505                 510         


Ser Ser Ser Ser Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro 
        515                 520                 525             


Gln Lys Pro Gln Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr 
    530                 535                 540                 


Asn Ala Phe Ser Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn 
545                 550                 555                 560 


Glu Asp Glu Ala Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe 
                565                 570                 575     


Ala Ser Leu Phe Ser Asp 
            580         


<210>  587
<211>  3315
<212>  DNA
<213>  Homo sapiens

<400>  587
atggccagga gaggtaagaa gcccgtggtg agaacgctgg aggatctgac gctggactcg       60

ggttatggtg gcgcggcgga ctcggtgcgc tcctccaact tgtctttgtg ctgttccgac      120

tcgcacccgg cgtccccgta tggcgggagc tgctggccgc ctctagctga ctccatgcac      180

agccggcaca acagctttga cactgtcaac actgccctgg tggaagactc cgaggggctg      240

gactgcgccg gccagcactg ctcgcggctg ctgccggacc tagacgaggt cccctggact      300

ctccaggagc tggaggcgct gctgctgcgt tcgcgggatc cccgggcagg cccggcggtc      360

cccggcggcc tgcccaagga cgcgctggcc aagctgtcga cgctggtgag ccgggcgctg      420

gtgcgcatag ccaaagaggc gcagcgcctg agcctgcgct tcgccaagtg caccaagtac      480

gagatccaga gcgccatgga gatcgtgctg tcctggggcc tggccgcgca ctgtacggcg      540

gctgcgctgg ccgcactgtc cctctacaac atgagcagcg ccggcggcga ccgcctgggc      600

cgcggcaagt cggcccgctg cggcctcacc ttctccgtgg gccgcgtgta tcgctggatg      660

gtggacagcc gcgtggcgct gcgcatccac gagcacgccg ccatctacct gacagcctgc      720

atggagagcc tcttccggga catctactcg cgggtcgtgg cctccggggt gccccggagc      780

tgcagtggcc ctgggtcagg ctcgggctcc ggcccaggcc cgagctcggg ccctggtgcg      840

gcccccgcgg cggataaaga gcgggaggcg cccgggggag gagcggcgag cggcggcgcc      900

tgcagcgcag ccagcagcgc cagcgggggc agcagctgtt gcgccccgcc ggccgccgcg      960

gccgccgcag tcccgccggc agccgccgcc aaccaccacc atcaccacca ccatgcgctc     1020

cacgaggcgc ccaagttcac cgtggagacc ctggagcaca cggtcaacaa cgactcggag     1080

atctggggtc tcctgcagcc ctaccagcac ctgatctgcg ggaagaacgc cagcggggtg     1140

ctgtgcctac cagacagcct gaatcttcac agagacccac agcggtcaaa caagccaggg     1200

gaactgccca tgttcagcca gtcggagctg aggaccatcg agcagtcttt gctggccacg     1260

cgcgtaggca gcatcgccga attgagtgac ctggtgtccc gtgcaatgca tcacctgcag     1320

cccctcaatg ccaagcacca cggcaatggc acccccctgc accacaagca gggggcactg     1380

tactgggagc ccgaggccct gtacaccctt tgctatttca tgcactgccc acaaatggaa     1440

tgggaaaacc ccaacgtgga gccttccaaa gtcaacctcc aggtggaaag gcccttcctc     1500

gtgctgccgc cgctgatgga gtggatccgg gtggccgtgg cgcacgccgg ccaccgccgc     1560

agcttctcca tggacagcga cgacgtccgc caggcggccc ggctgctgct gcccggcgtg     1620

gactgcgagc cgcgccagct cagggccgac gactgctttt gtgcatctcg aaagctggat     1680

gcggtggcca tcgaagccaa gtttaagcag gacctgggtt tccggatgct gaactgtgga     1740

cgaacagacc tggtgaagca ggcagtgtct ctgctggggc ccgatgggat caacaccatg     1800

agcgaacagg gcatgactcc cctgatgtat gcctgcgtcc gtggggacga ggcgatggtt     1860

cagatgctgc tggatgccgg agctgacctg aatgtggagg ttgtcagtac tcctcataaa     1920

tatccatccg tccaccccga gacccgccat tggacggctc tgacttttgc tgtgttgcat     1980

ggacatattc ctgtagttca gctcctcctg gatgctgggg ccaaggtgga aggctcagtg     2040

gagcatggcg aggagaacta ctcggaaaca cccctccagc tggcagctgc tgtaggaaat     2100

tttgagctgg ttagtttgct gttggagcgt ggtgccgatc ccctgatagg aaccatgtac     2160

aggaatggaa tttctacaac cccccagggt gatatgaact ctttcagcca ggctgcagcc     2220

cacggacaca ggaatgtgtt ccgcaaactg ctcgcccagc cagagaagga gaagagtgat     2280

atcctgtccc tggaggagat tctggccgag gggactgacc tggcggagac agccccgccc     2340

cccttgtgcg ccagccgcaa cagcaaggcc aaactgaggg ccctgaggga ggccatgtat     2400

cacagcgctg agcatggcta cgtggatgtc acaattgata tcaggagcat aggcgtcccg     2460

tggactctgc acacgtggct ggagtctttg cggatcgcct tccagcagca ccgcaggcct     2520

ctcatccagt gcttgttaaa ggagtttaag accattcagg aggaggaata cacggaggag     2580

ctcgttaccc aaggcctgcc cctgatgttt gagatcctga aagcgagcaa gaatgaagtg     2640

atcagccagc agctgtgcgt catcttcaca cactgctacg ggccctaccc catccccaag     2700

ctcacagaaa tcaaacggaa acagacctcg cgcttggatc ctcattttct taacaataaa     2760

gaaatgtctg atgttacatt tctggtagaa ggaagaccat tttatgctca caaagtgctg     2820

ttatttacag cctctccaag gttcaaagca ctcctctcca gcaagccgac aaatgatggc     2880

acctgcatag agattggtta tgtgaaatac tccatctttc agctggttat gcagtatctc     2940

tactatggtg gcccagagtc actgctcatt aaaaacaatg agatcatgga gcttctgtct     3000

gctgctaagt ttttccagct ggaggctttg cagcgacact gtgagattat ctgtgcgaaa     3060

agcatcaata ccgacaactg tgtggatatt tacaaccatg ccaagtttct tggagtcaca     3120

gagctctcag catattgcga aggctacttt ctcaaaaaca tgatggtcct cattgaaaac     3180

gaagcattca agcagctcct gtatgacaaa aatggtgaag ggaccggcca ggatgtgctc     3240

caggacttac agaggacgtt ggccatcaga attcagtcca tccacttgtc gtcttccaaa     3300

ggttccgtgg tatga                                                      3315


<210>  588
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  588

Met Ala Arg Arg Gly Lys Lys Pro Val Val Arg Thr Leu Glu Asp Leu 
1               5                   10                  15      


Thr Leu Asp Ser Gly Tyr Gly Gly Ala Ala Asp Ser Val Arg Ser Ser 
            20                  25                  30          


Asn Leu Ser Leu Cys Cys Ser Asp Ser His Pro Ala Ser Pro Tyr Gly 
        35                  40                  45              


Gly Ser Cys Trp Pro Pro Leu Ala Asp Ser Met His Ser Arg His Asn 
    50                  55                  60                  


Ser Phe Asp Thr Val Asn Thr Ala Leu Val Glu Asp Ser Glu Gly Leu 
65                  70                  75                  80  


Asp Cys Ala Gly Gln His Cys Ser Arg Leu Leu Pro Asp Leu Asp Glu 
                85                  90                  95      


Val Pro Trp Thr Leu Gln Glu Leu Glu Ala Leu Leu Leu Arg Ser Arg 
            100                 105                 110         


Asp Pro Arg Ala Gly Pro Ala Val Pro Gly Gly Leu Pro Lys Asp Ala 
        115                 120                 125             


Leu Ala Lys Leu Ser Thr Leu Val Ser Arg Ala Leu Val Arg Ile Ala 
    130                 135                 140                 


Lys Glu Ala Gln Arg Leu Ser Leu Arg Phe Ala Lys Cys Thr Lys Tyr 
145                 150                 155                 160 


Glu Ile Gln Ser Ala Met Glu Ile Val Leu Ser Trp Gly Leu Ala Ala 
                165                 170                 175     


His Cys Thr Ala Ala Ala Leu Ala Ala Leu Ser Leu Tyr Asn Met Ser 
            180                 185                 190         


Ser Ala Gly Gly Asp Arg Leu Gly Arg Gly Lys Ser Ala Arg Cys Gly 
        195                 200                 205             


Leu Thr Phe Ser Val Gly Arg Val Tyr Arg Trp Met Val Asp Ser Arg 
    210                 215                 220                 


Val Ala Leu Arg Ile His Glu His Ala Ala Ile Tyr Leu Thr Ala Cys 
225                 230                 235                 240 


Met Glu Ser Leu Phe Arg Asp Ile Tyr Ser Arg Val Val Ala Ser Gly 
                245                 250                 255     


Val Pro Arg Ser Cys Ser Gly Pro Gly Ser Gly Ser Gly Ser Gly Pro 
            260                 265                 270         


Gly Pro Ser Ser Gly Pro Gly Ala Ala Pro Ala Ala Asp Lys Glu Arg 
        275                 280                 285             


Glu Ala Pro Gly Gly Gly Ala Ala Ser Gly Gly Ala Cys Ser Ala Ala 
    290                 295                 300                 


Ser Ser Ala Ser Gly Gly Ser Ser Cys Cys Ala Pro Pro Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Asn His His His His His 
                325                 330                 335     


His His Ala Leu His Glu Ala Pro Lys Phe Thr Val Glu Thr Leu Glu 
            340                 345                 350         


His Thr Val Asn Asn Asp Ser Glu Ile Trp Gly Leu Leu Gln Pro Tyr 
        355                 360                 365             


Gln His Leu Ile Cys Gly Lys Asn Ala Ser Gly Val Leu Cys Leu Pro 
    370                 375                 380                 


Asp Ser Leu Asn Leu His Arg Asp Pro Gln Arg Ser Asn Lys Pro Gly 
385                 390                 395                 400 


Glu Leu Pro Met Phe Ser Gln Ser Glu Leu Arg Thr Ile Glu Gln Ser 
                405                 410                 415     


Leu Leu Ala Thr Arg Val Gly Ser Ile Ala Glu Leu Ser Asp Leu Val 
            420                 425                 430         


Ser Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His His Gly 
        435                 440                 445             


Asn Gly Thr Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp Glu Pro 
    450                 455                 460                 


Glu Ala Leu Tyr Thr Leu Cys Tyr Phe Met His Cys Pro Gln Met Glu 
465                 470                 475                 480 


Trp Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln Val Glu 
                485                 490                 495     


Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val Ala 
            500                 505                 510         


Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp Asp 
        515                 520                 525             


Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu Pro 
    530                 535                 540                 


Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu Asp 
545                 550                 555                 560 


Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg Met 
                565                 570                 575     


Leu Asn Cys Gly Arg Thr Asp Leu Val Lys Gln Ala Val Ser Leu Leu 
            580                 585                 590         


Gly Pro Asp Gly Ile Asn Thr Met Ser Glu Gln Gly Met Thr Pro Leu 
        595                 600                 605             


Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu Leu 
    610                 615                 620                 


Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Thr Pro His Lys 
625                 630                 635                 640 


Tyr Pro Ser Val His Pro Glu Thr Arg His Trp Thr Ala Leu Thr Phe 
                645                 650                 655     


Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp Ala 
            660                 665                 670         


Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr Ser 
        675                 680                 685             


Glu Thr Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu Val 
    690                 695                 700                 


Ser Leu Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Thr Met Tyr 
705                 710                 715                 720 


Arg Asn Gly Ile Ser Thr Thr Pro Gln Gly Asp Met Asn Ser Phe Ser 
                725                 730                 735     


Gln Ala Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu Ala 
            740                 745                 750         


Gln Pro Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile Leu 
        755                 760                 765             


Ala Glu Gly Thr Asp Leu Ala Glu Thr Ala Pro Pro Pro Leu Cys Ala 
    770                 775                 780                 


Ser Arg Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met Tyr 
785                 790                 795                 800 


His Ser Ala Glu His Gly Tyr Val Asp Val Thr Ile Asp Ile Arg Ser 
                805                 810                 815     


Ile Gly Val Pro Trp Thr Leu His Thr Trp Leu Glu Ser Leu Arg Ile 
            820                 825                 830         


Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys Glu 
        835                 840                 845             


Phe Lys Thr Ile Gln Glu Glu Glu Tyr Thr Glu Glu Leu Val Thr Gln 
    850                 855                 860                 


Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu Val 
865                 870                 875                 880 


Ile Ser Gln Gln Leu Cys Val Ile Phe Thr His Cys Tyr Gly Pro Tyr 
                885                 890                 895     


Pro Ile Pro Lys Leu Thr Glu Ile Lys Arg Lys Gln Thr Ser Arg Leu 
            900                 905                 910         


Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Thr Phe Leu 
        915                 920                 925             


Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Thr Ala 
    930                 935                 940                 


Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Thr Asn Asp Gly 
945                 950                 955                 960 


Thr Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln Leu Val 
                965                 970                 975     


Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile Lys Asn 
            980                 985                 990         


Asn Glu Ile Met Glu Leu Leu Ser  Ala Ala Lys Phe Phe  Gln Leu Glu 
        995                 1000                 1005             


Ala Leu  Gln Arg His Cys Glu  Ile Ile Cys Ala Lys  Ser Ile Asn 
    1010                 1015                 1020             


Thr Asp  Asn Cys Val Asp Ile  Tyr Asn His Ala Lys  Phe Leu Gly 
    1025                 1030                 1035             


Val Thr  Glu Leu Ser Ala Tyr  Cys Glu Gly Tyr Phe  Leu Lys Asn 
    1040                 1045                 1050             


Met Met  Val Leu Ile Glu Asn  Glu Ala Phe Lys Gln  Leu Leu Tyr 
    1055                 1060                 1065             


Asp Lys  Asn Gly Glu Gly Thr  Gly Gln Asp Val Leu  Gln Asp Leu 
    1070                 1075                 1080             


Gln Arg  Thr Leu Ala Ile Arg  Ile Gln Ser Ile His  Leu Ser Ser 
    1085                 1090                 1095             


Ser Lys  Gly Ser Val Val 
    1100                 


<210>  589
<211>  846
<212>  DNA
<213>  Homo sapiens

<400>  589
atgtcccacg ggacctacta cgagtgtgag ccccggggtg gccagcagcc actcgagttc       60

tcagggggcc gagctgggcc cggggagcta ggggacatgt gtgagcatga ggcctccatt      120

gacctctccg cctacatcga gtctggggaa gagcagcttc tctccgatct ctttgccgtg      180

aagccagcgc ctgaggccag aggcctcaag ggccccggaa cccctgcctt cccccactac      240

ttgccgcctg accctcggcc ctttgcctac cctccacata ccttcggccc agacaggaag      300

gcgctggggc ctggcatcta cagcagccca gggagctacg accccagggc tgtggcggtg      360

aaggaggagc cccgggggcc agagggcagc cgagctgcca gccgaggcag ctacaatccc      420

ctgcagtacc aagtggcaca ctgtgggcag acagccatgc acctgccccc aactctggca      480

gcacccggcc agcctctgcg cgttctcaag gcccctttgg ccactgccgc acccccctgc      540

agtcccctcc tgaaggcgcc ctccccggct ggccccttac acaagggcaa gaaggcagtg      600

aacaaagata gccttgagta ccggctgagg cgggagcgca acaacatcgc cgtgcgcaag      660

agccgagaca aggccaagag gcgcattctg gagacgcagc agaaggtgct ggagtacatg      720

gcagagaacg agcgcctccg cagccgcgtg gagcagctca cccaggagct agacaccctc      780

cgcaacctct tccgccagat tcctgaggcg gccaacctca tcaagggcgt ggggggttgc      840

agctga                                                                 846


<210>  590
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  590

Met Ser His Gly Thr Tyr Tyr Glu Cys Glu Pro Arg Gly Gly Gln Gln 
1               5                   10                  15      


Pro Leu Glu Phe Ser Gly Gly Arg Ala Gly Pro Gly Glu Leu Gly Asp 
            20                  25                  30          


Met Cys Glu His Glu Ala Ser Ile Asp Leu Ser Ala Tyr Ile Glu Ser 
        35                  40                  45              


Gly Glu Glu Gln Leu Leu Ser Asp Leu Phe Ala Val Lys Pro Ala Pro 
    50                  55                  60                  


Glu Ala Arg Gly Leu Lys Gly Pro Gly Thr Pro Ala Phe Pro His Tyr 
65                  70                  75                  80  


Leu Pro Pro Asp Pro Arg Pro Phe Ala Tyr Pro Pro His Thr Phe Gly 
                85                  90                  95      


Pro Asp Arg Lys Ala Leu Gly Pro Gly Ile Tyr Ser Ser Pro Gly Ser 
            100                 105                 110         


Tyr Asp Pro Arg Ala Val Ala Val Lys Glu Glu Pro Arg Gly Pro Glu 
        115                 120                 125             


Gly Ser Arg Ala Ala Ser Arg Gly Ser Tyr Asn Pro Leu Gln Tyr Gln 
    130                 135                 140                 


Val Ala His Cys Gly Gln Thr Ala Met His Leu Pro Pro Thr Leu Ala 
145                 150                 155                 160 


Ala Pro Gly Gln Pro Leu Arg Val Leu Lys Ala Pro Leu Ala Thr Ala 
                165                 170                 175     


Ala Pro Pro Cys Ser Pro Leu Leu Lys Ala Pro Ser Pro Ala Gly Pro 
            180                 185                 190         


Leu His Lys Gly Lys Lys Ala Val Asn Lys Asp Ser Leu Glu Tyr Arg 
        195                 200                 205             


Leu Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys 
    210                 215                 220                 


Ala Lys Arg Arg Ile Leu Glu Thr Gln Gln Lys Val Leu Glu Tyr Met 
225                 230                 235                 240 


Ala Glu Asn Glu Arg Leu Arg Ser Arg Val Glu Gln Leu Thr Gln Glu 
                245                 250                 255     


Leu Asp Thr Leu Arg Asn Leu Phe Arg Gln Ile Pro Glu Ala Ala Asn 
            260                 265                 270         


Leu Ile Lys Gly Val Gly Gly Cys Ser 
        275                 280     


<210>  591
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  591
atggccggag ctggaccgac catgctgcta cgagaagaga atggctgttg cagtcggcgt       60

cagagcagct ccagtgctgg ggattcggac ggagagcgcg aggactcggc ggctgagcgc      120

gcccgacagc agctagaggc gctgctcaac aagactatgc gcattcgcat gacagatgga      180

cggacactgg tcggctgctt cctctgcact gaccgtgact gcaatgtcat cctgggctcg      240

gcgcaggagt tcctcaagcc gtcggattcc ttctctgccg gggagccccg tgtgctgggc      300

ctggccatgg tacccggaca ccacatcgtt tccattgagg tgcagaggga gagtctgacc      360

gggcctccgt atctctga                                                    378


<210>  592
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  592

Met Ala Gly Ala Gly Pro Thr Met Leu Leu Arg Glu Glu Asn Gly Cys 
1               5                   10                  15      


Cys Ser Arg Arg Gln Ser Ser Ser Ser Ala Gly Asp Ser Asp Gly Glu 
            20                  25                  30          


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
    50                  55                  60                  


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
65                  70                  75                  80  


Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro 
                85                  90                  95      


Arg Val Leu Gly Leu Ala Met Val Pro Gly His His Ile Val Ser Ile 
            100                 105                 110         


Glu Val Gln Arg Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
        115                 120                 125 


<210>  593
<211>  2412
<212>  DNA
<213>  Homo sapiens

<400>  593
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacggat ggtctggcaa catggagaga     1980

atcatgaaag cacaagcgta ccaaacgggc aaggacatct ctacaaatta ctatgcgagt     2040

cagaagaaaa catttgaaat taatcccaga cacccgctga tcagagacat gcttcgacga     2100

attaaggaag atgaagatga taaaacagtt ttggatcttg ctgtggtttt gtttgaaaca     2160

gcaacgcttc ggtcagggta tcttttacca gacactaaag catatggaga tagaatagaa     2220

agaatgcttc gcctcagttt gaacattgac cctgatgcaa aggtggaaga agagcccgaa     2280

gaagaacctg aagagacagc agaagacaca acagaagaca cagagcaaga cgaagatgaa     2340

gaaatggatg tgggaacaga tgaagaagaa gaaacagcaa aggaatctac agctgaaaaa     2400

gatgaattgt aa                                                         2412


<210>  594
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  594

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  595
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  595
atgagctccc agattcgtca gaattattcc accgacgtgg aggcagccgt caacagcctg       60

gtcaatttgt acctgcaggc ctcctacacc tacctctctc tgggcttcta tttcgaccgc      120

gatgatgtgg ctctggaagg cgtgagccac ttcttccgcg aattggccga ggagaagcgc      180

gagggctacg agcgtctcct gaagatgcaa aaccagcgtg gcggccgcgc tctcttccag      240

gacatcaaga agccagctga agatgagtgg ggtaaaaccc cagacgccat gaaagctgcc      300

atggccctgg agaaaaagct gaaccaggcc cttttggatc ttcatgccct gggttctgcc      360

cgcacggacc cccatctctg tgacttcctg gagactcact tcctagatga ggaagtgaag      420

cttatcaaga agatgggtga ccacctgacc aacctccaca ggctgggtgg cccggaggct      480

gggctgggcg agtatctctt cgaaaggctc actctcaagc acgactaa                   528


<210>  596
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  596

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 175 


<210>  597
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  597
atggcgaggc gcgggccagg gtggcggccg cttctgctgc tcgtgctgct ggcgggcgcg       60

gcgcagggcg gcctctactt ccgccgggga cagacctgct accggcctct gcggggggac      120

gggctggctc cgctggggcg cagcacatac ccccggcctc atgagtacct gtccccagcg      180

gatctgccca agagctggga ctggcgcaat gtggatggtg tcaactatgc cagcatcacc      240

cggaaccagc acatccccca atactgcggc tcctgctggg cccacgccag caccagcgct      300

atggcggatc ggatcaacat caagaggaag ggagcgtggc cctccaccct cctgtccgtg      360

cagaacgtca tcgactgcgg taacgctggc tcctgtgaag ggggtaatga cctgtccgtg      420

tgggactacg cccaccagca cggcatccct gacgagacct gcaacaacta ccaggccaag      480

gaccaggagt gtgacaagtt taaccaatgt gggacatgca atgaattcaa agagtgccac      540

gccatccgga actacaccct ctggagggtg ggagactacg gctccctctc tgggagggag      600

aagatgatgg cagaaatcta tgcaaatggt cccatcagct gtggaataat ggcaacagaa      660

agactggcta actacaccgg aggcatctat gccgaatacc aggacaccac atatataaac      720

catgtcgttt ctgtggctgg gtggggcatc agtgatggga ctgagtactg gattgtccgg      780

aattcatggg gtgaaccatg gggcgagaga ggctggctga ggatcgtgac cagcacctat      840

aaggatggga agggcgccag atacaacctt gccatcgagg agcactgtac atttggggac      900

cccatcgttt aa                                                          912


<210>  598
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  599
<211>  2562
<212>  DNA
<213>  Homo sapiens

<400>  599
atgtttttac ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta       60

ccaaagactg tgaaattatt cgatgacatg atgtatgaat taaccagtca agccagagga      120

ctgtcaagcc aaaatttgga aatccagacc actctaagga atattttaca aacaatggtg      180

cagctcttag gagctctcac aggatgtgtt cagcatatct gtgccacaca ggaatccatc      240

attttggaaa atattcagag tctcccctcc tcagtccttc atataattaa aagcacattt      300

gtgcattgta agaatagtga atctgtgtat tctgggtgtt tacacctagt ttcagacctt      360

ctccaggctc ttttcaagga ggcctattct cttcaaaagc agttaatgga actgctggac      420

atggtttgca tggacccttt agtagatgac aatgatgata ttttgaatat ggtaatagtt      480

attcattctt tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc      540

aatacttgga agtttataat taagcagagc cttaagcacc agtccataat aaaaagccag      600

ttgaaacaca aagatataat tactagcttg tgtgaagaca ttcttttctc cttccattct      660

tgtttacagt tagctgagca gatgacacag tcagatgcac aggataatgc tgactacaga      720

ttatttcaga aaacactcaa attgtgtcgt ttttttgcca actccctttt gcactacgct      780

aaggaatttc ttcctttcct ctctgattct tgctgtactt tgcaccaact gtatcttcag      840

atacacagca agtttcctcc aagcctttat gctaccagga tttctaaagc acaccaagag      900

gaaatagcag gtgctttcct agtgacactg gatccactta tcagtcagct gctcacattt      960

cagcctttca tgcaggtggt tttggacagt aaattagacc tgccatgtga actgcagttt     1020

ccacaatgtc ttcttctggt tgttgtcatg gataagctgc catctcagcc taaggaagtg     1080

caaaccctgt ggtgcacaga cagccaggtc tcagaaacga caaccaggat atctctactc     1140

aaagccgttt tctacagttt tgagcagtgt tctggtgaac tctctctacc tgttcattta     1200

cagggattaa agagtaaggg gaaagctgag gtggctgtca ccttgtatca gcatgtttgt     1260

gttcatctgt gtacatttat tacttccttt catccctcac tgtttgctga actggatgct     1320

gctctgctga atgctgtact tagtgctaat atgatcacct ctttgttagc tatggatgca     1380

tggtgcttcc ttgctcgata tgggactgct gaactgtgtg cacaccatgt caccatagtg     1440

gctcatctga taaagtcatg ccctggagaa tgttatcaac tcatcaacct atcaatactg     1500

ttgaagcgtc tctttttctt catggcacca ccccatcagc tggagtttat ccagaaattt     1560

tccccaaaag aagcagaaaa tctgcctctg tggcaacata tttccttcca ggcgttacct     1620

cctgagctta gggaacaaac tgtccatgag gtcaccacag taggcactgc agaatgcagg     1680

aaatggctga gcaggagtcg tactttggga gaactagaat ctctgaacac agtactgtct     1740

gctttgcttg cagtatgtaa ttctgctggt gaagctttgg atacaggaaa acaaactgca     1800

attatcgaag ttgtgagtca gctttgggct tttttaaaca ttaaacaggt agcagatcaa     1860

ccttatgttc aacagacatt cagcctttta cttccactgt tgggattttt cattcaaact     1920

ctagatccta aactgatact tcaggcagta actttgcaga cctcgctact taaattagag     1980

cttcctgact atgttcgttt ggcaatgttg gattttgtat cttctttagg aaaacttttt     2040

atacctgaag ctatccagga cagaattctg cccaacctgt cctgtatgtt tgccttactg     2100

ctagctgaca ggagttggct gctagaacaa cataccttgg aggcgtttac tcagttcgct     2160

gagggaacaa atcatgaaga gatagttcca cagtgtctca gttctgaaga aactaagaac     2220

aaagttgtat cctttctgga gaagactggg tttgtagatg aaactgaagc tgccaaagtg     2280

gaacgtgtga aacaggaaaa aggtattttc tgggaaccct ttgctaatgt gactgtagaa     2340

gaagcaaaga ggtcatcttt acagccttat gcaaaaagag ctcgtcagga gttcccctgg     2400

gaagaagagt acaggtcagc gctgcataca atagcagggg ctttggaagc aactgagtca     2460

ctactccaaa agggtcctgc tccagcctgg ctttcaatgg aaatggaggc gctccaagaa     2520

aggatggata agctaaaacg ttacatacat actctagggt ga                        2562


<210>  600
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Phe Leu Pro His Met Asn His Leu Thr Leu Glu Gln Thr Phe Phe 
1               5                   10                  15      


Ser Gln Val Leu Pro Lys Thr Val Lys Leu Phe Asp Asp Met Met Tyr 
            20                  25                  30          


Glu Leu Thr Ser Gln Ala Arg Gly Leu Ser Ser Gln Asn Leu Glu Ile 
        35                  40                  45              


Gln Thr Thr Leu Arg Asn Ile Leu Gln Thr Met Val Gln Leu Leu Gly 
    50                  55                  60                  


Ala Leu Thr Gly Cys Val Gln His Ile Cys Ala Thr Gln Glu Ser Ile 
65                  70                  75                  80  


Ile Leu Glu Asn Ile Gln Ser Leu Pro Ser Ser Val Leu His Ile Ile 
                85                  90                  95      


Lys Ser Thr Phe Val His Cys Lys Asn Ser Glu Ser Val Tyr Ser Gly 
            100                 105                 110         


Cys Leu His Leu Val Ser Asp Leu Leu Gln Ala Leu Phe Lys Glu Ala 
        115                 120                 125             


Tyr Ser Leu Gln Lys Gln Leu Met Glu Leu Leu Asp Met Val Cys Met 
    130                 135                 140                 


Asp Pro Leu Val Asp Asp Asn Asp Asp Ile Leu Asn Met Val Ile Val 
145                 150                 155                 160 


Ile His Ser Leu Leu Asp Ile Cys Ser Val Ile Ser Ser Met Asp His 
                165                 170                 175     


Ala Phe His Ala Asn Thr Trp Lys Phe Ile Ile Lys Gln Ser Leu Lys 
            180                 185                 190         


His Gln Ser Ile Ile Lys Ser Gln Leu Lys His Lys Asp Ile Ile Thr 
        195                 200                 205             


Ser Leu Cys Glu Asp Ile Leu Phe Ser Phe His Ser Cys Leu Gln Leu 
    210                 215                 220                 


Ala Glu Gln Met Thr Gln Ser Asp Ala Gln Asp Asn Ala Asp Tyr Arg 
225                 230                 235                 240 


Leu Phe Gln Lys Thr Leu Lys Leu Cys Arg Phe Phe Ala Asn Ser Leu 
                245                 250                 255     


Leu His Tyr Ala Lys Glu Phe Leu Pro Phe Leu Ser Asp Ser Cys Cys 
            260                 265                 270         


Thr Leu His Gln Leu Tyr Leu Gln Ile His Ser Lys Phe Pro Pro Ser 
        275                 280                 285             


Leu Tyr Ala Thr Arg Ile Ser Lys Ala His Gln Glu Glu Ile Ala Gly 
    290                 295                 300                 


Ala Phe Leu Val Thr Leu Asp Pro Leu Ile Ser Gln Leu Leu Thr Phe 
305                 310                 315                 320 


Gln Pro Phe Met Gln Val Val Leu Asp Ser Lys Leu Asp Leu Pro Cys 
                325                 330                 335     


Glu Leu Gln Phe Pro Gln Cys Leu Leu Leu Val Val Val Met Asp Lys 
            340                 345                 350         


Leu Pro Ser Gln Pro Lys Glu Val Gln Thr Leu Trp Cys Thr Asp Ser 
        355                 360                 365             


Gln Val Ser Glu Thr Thr Thr Arg Ile Ser Leu Leu Lys Ala Val Phe 
    370                 375                 380                 


Tyr Ser Phe Glu Gln Cys Ser Gly Glu Leu Ser Leu Pro Val His Leu 
385                 390                 395                 400 


Gln Gly Leu Lys Ser Lys Gly Lys Ala Glu Val Ala Val Thr Leu Tyr 
                405                 410                 415     


Gln His Val Cys Val His Leu Cys Thr Phe Ile Thr Ser Phe His Pro 
            420                 425                 430         


Ser Leu Phe Ala Glu Leu Asp Ala Ala Leu Leu Asn Ala Val Leu Ser 
        435                 440                 445             


Ala Asn Met Ile Thr Ser Leu Leu Ala Met Asp Ala Trp Cys Phe Leu 
    450                 455                 460                 


Ala Arg Tyr Gly Thr Ala Glu Leu Cys Ala His His Val Thr Ile Val 
465                 470                 475                 480 


Ala His Leu Ile Lys Ser Cys Pro Gly Glu Cys Tyr Gln Leu Ile Asn 
                485                 490                 495     


Leu Ser Ile Leu Leu Lys Arg Leu Phe Phe Phe Met Ala Pro Pro His 
            500                 505                 510         


Gln Leu Glu Phe Ile Gln Lys Phe Ser Pro Lys Glu Ala Glu Asn Leu 
        515                 520                 525             


Pro Leu Trp Gln His Ile Ser Phe Gln Ala Leu Pro Pro Glu Leu Arg 
    530                 535                 540                 


Glu Gln Thr Val His Glu Val Thr Thr Val Gly Thr Ala Glu Cys Arg 
545                 550                 555                 560 


Lys Trp Leu Ser Arg Ser Arg Thr Leu Gly Glu Leu Glu Ser Leu Asn 
                565                 570                 575     


Thr Val Leu Ser Ala Leu Leu Ala Val Cys Asn Ser Ala Gly Glu Ala 
            580                 585                 590         


Leu Asp Thr Gly Lys Gln Thr Ala Ile Ile Glu Val Val Ser Gln Leu 
        595                 600                 605             


Trp Ala Phe Leu Asn Ile Lys Gln Val Ala Asp Gln Pro Tyr Val Gln 
    610                 615                 620                 


Gln Thr Phe Ser Leu Leu Leu Pro Leu Leu Gly Phe Phe Ile Gln Thr 
625                 630                 635                 640 


Leu Asp Pro Lys Leu Ile Leu Gln Ala Val Thr Leu Gln Thr Ser Leu 
                645                 650                 655     


Leu Lys Leu Glu Leu Pro Asp Tyr Val Arg Leu Ala Met Leu Asp Phe 
            660                 665                 670         


Val Ser Ser Leu Gly Lys Leu Phe Ile Pro Glu Ala Ile Gln Asp Arg 
        675                 680                 685             


Ile Leu Pro Asn Leu Ser Cys Met Phe Ala Leu Leu Leu Ala Asp Arg 
    690                 695                 700                 


Ser Trp Leu Leu Glu Gln His Thr Leu Glu Ala Phe Thr Gln Phe Ala 
705                 710                 715                 720 


Glu Gly Thr Asn His Glu Glu Ile Val Pro Gln Cys Leu Ser Ser Glu 
                725                 730                 735     


Glu Thr Lys Asn Lys Val Val Ser Phe Leu Glu Lys Thr Gly Phe Val 
            740                 745                 750         


Asp Glu Thr Glu Ala Ala Lys Val Glu Arg Val Lys Gln Glu Lys Gly 
        755                 760                 765             


Ile Phe Trp Glu Pro Phe Ala Asn Val Thr Val Glu Glu Ala Lys Arg 
    770                 775                 780                 


Ser Ser Leu Gln Pro Tyr Ala Lys Arg Ala Arg Gln Glu Phe Pro Trp 
785                 790                 795                 800 


Glu Glu Glu Tyr Arg Ser Ala Leu His Thr Ile Ala Gly Ala Leu Glu 
                805                 810                 815     


Ala Thr Glu Ser Leu Leu Gln Lys Gly Pro Ala Pro Ala Trp Leu Ser 
            820                 825                 830         


Met Glu Met Glu Ala Leu Gln Glu Arg Met Asp Lys Leu Lys Arg Tyr 
        835                 840                 845             


Ile His Thr Leu Gly 
    850             


<210>  601
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  601
atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc cttttcagga       60

gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc tgcaacaaat      120

tatgagaccc aagactccca taaagctgga cccattggca ttctctttga actagtgcat      180

atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag aaaattctta      240

cagaaggcat atgaatccaa aattgattat gacaagccag aaactgtaat cttaggtcta      300

aagattgtct actatgaagc agggattatt ctatgctgtg tcctggggct gctgtttatt      360

attctgatgc ctctggtggg gtatttcttt tgtatgtgtc gttgctgtaa caaatgtggt      420

ggagaaatgc accagcgaca gaaggaaaat gggcccttcc tgaggaaatg ctttgcaatc      480

tccctgttgg tgatttgtat aataataagc attggcatct tctatggttt tgtggcaaat      540

caccaggtaa gaacccggat caaaaggagt cggaaactgg cagatagcaa tttcaaggac      600

ttgcgaactc tcttgaatga aactccagag caaatcaaat atatattggc ccagtacaac      660

actaccaagg acaaggcgtt cacagatctg aacagtatca attcagtgct aggaggcgga      720

attcttgacc gactgagacc caacatcatc cctgttcttg atgagattaa gtccatggca      780

acagcgatca aggagaccaa agaggcgttg gagaacatga acagcacctt gaagagcttg      840

caccaacaaa gtacacagct tagcagcagt ctgaccagcg tgaaaactag cctgcggtca      900

tctctcaatg accctctgtg cttggtgcat ccatcaagtg aaacctgcaa cagcatcaga      960

ttgtctctaa gccagctgaa tagcaaccct gaactgaggc agcttccacc cgtggatgca     1020

gaacttgaca acgttaataa cgttcttagg acagatttgg atggcctggt ccaacagggc     1080

tatcaatccc ttaatgatat acctgacaga gtacaacgcc aaaccacgac tgtcgtagca     1140

ggtatcaaaa gggtcttgaa ttccattggt tcagatatcg acaatgtaac tcagcgtctt     1200

cctattcagg atatactctc agcattctct gtttatgtta ataacactga aagttacatc     1260

cacagaaatt tacctacatt ggaagagtat gattcatact ggtggctggg tggcctggtc     1320

atctgctctc tgctgaccct catcgtgatt ttttactacc tgggcttact gtgtggcgtg     1380

tgcggctatg acaggcatgc caccccgacc acccgaggct gtgtctccaa caccggaggc     1440

gtcttcctca tggttggagt tggattaagt ttcctctttt gctggatatt gatgatcatt     1500

gtggttctta cctttgtctt tggtgcaaat gtggaaaaac tgatctgtga accttacacg     1560

agcaaggaat tattccgggt tttggataca ccctacttac taaatgaaga ctgggaatac     1620

tatctctctg ggaagctatt taataaatca aaaatgaagc tcacttttga acaagtttac     1680

agtgactgca aaaaaaatag aggcacttac ggcactcttc acctgcagaa cagcttcaat     1740

atcagtgaac atctcaacat taatgagcat actggaagca taagcagtga attggaaagt     1800

ctgaaggtaa atcttaatat ctttctgttg ggtgcagcag gaagaaaaaa ccttcaggat     1860

tttgctgctt gtggaataga cagaatgaat tatgacagct acttggctca gactggtaaa     1920

tcccccgcag gagtgaatct tttatcattt gcatatgatc tagaagcaaa agcaaacagt     1980

ttgcccccag gaaatttgag gaactccctg aaaagagatg cacaaactat taaaacaatt     2040

caccagcaac gagtccttcc tatagaacaa tcactgagca ctctatacca aagcgtcaag     2100

atacttcaac gcacagggaa tggattgttg gagagagtaa ctaggattct agcttctctg     2160

gattttgctc agaacttcat cacaaacaat acttcctctg ttattattga ggaaactaag     2220

aagtatggga gaacaataat aggatatttt gaacattatc tgcagtggat cgagttctct     2280

atcagtgaga aagtggcatc gtgcaaacct gtggccaccg ctctagatac tgctgttgat     2340

gtctttctgt gtagctacat tatcgacccc ttgaatttgt tttggtttgg cataggaaaa     2400

gctactgtat ttttacttcc ggctctaatt tttgcggtaa aactggctaa gtactatcgt     2460

cgaatggatt cggaggacgt gtacgatgat gttgaaacta tacccatgaa aaatatggaa     2520

aatggtaata atggttatca taaagatcat gtatatggta ttcacaatcc tgttatgaca     2580

agcccatcac aacattga                                                   2598


<210>  602
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  603
<211>  5844
<212>  DNA
<213>  Homo sapiens

<400>  603
atgatgcagc tcacattgaa cactctcttt cctgttgttt ccacaccagc tattacgtat       60

attgtcaccg tcttcactgg ggatgtccgg ggggctggta ccaaatccaa aatctacttg      120

gtcatgtatg gggccagagg gaataagaac agtgggaaaa tcttcctgga gggcggcgtg      180

tttgaccgag gccgcacgga catcttccac atcgagctgg ctgtcctcct tagccccctg      240

agtcgggtct ccgtcgggca tggcaatgtg ggtgtcaaca gaggctggtt ctgtgagaag      300

gtggtgattc tgtgcccctt cactggtatc cagcagacct tcccttgtag caactggctg      360

gatgagaaga aagcggatgg gttgattgag aggcagctct atgagatggt gtctctcagg      420

aagaagcggc tgaaaaaatt cccttggtcc ctgtgggtct ggacaaccga cctaaagaaa      480

gctggtacca actctcccat cttcatccag atttatgggc agaaggggcg gacagatgag      540

attctcctga atcccaacaa caagtggttc aaacccggca taatcgagaa gtttaggatt      600

gagctcccgg atcttggcag gttttataag attcgagtat ggcatgataa aaggagttct      660

ggttctggat ggcatttaga aaggatgacc ctgatgaaca ctctgaacaa agacaagtac      720

aacttcaatt gcaaccgctg gctggatgcc aatgaggatg acaatgagat agtgagggaa      780

atgactgcag aaggcccaac agtgcgcagg atcatgggca tggcccggta ccatgtgact      840

gtgtgcacag gtgaacttga aggtgctggg accgatgcca acgtctatct ctgccttttt      900

ggtgatgtgg gggacacggg ggaacggctg ctctacaact gcaggaataa cacagacctg      960

tttgaaaagg gcaatgctga cgagttcact atcgagtctg tcaccatgcg gaatgtgagg     1020

cgggtgagga tcagacacga tggcaaaggc tccggcagcg gctggtacct ggacagagtg     1080

ctggtgagag aggaggggca gcctgagagc gacaacgtgg agttcccatg tctcaggtgg     1140

ttggacaagg ataaggatga tgggcagctg gtccgagagt tgctacccag tgacagcagc     1200

gcgacactga agaactttcg ctatcacatc agcttgaaga ctggggatgt ctctggggcc     1260

agcacggatt ctagagtcta catcaagctc tatggggata aatctgacac catcaagcaa     1320

gttcttcttg tctctgacaa caacctcaaa gactactttg aacgtggccg ggtggatgag     1380

ttcaccctcg agaccctgaa cattggaaat atcaaccggc tggtgattgg gcatgacagc     1440

actggcatgc atgccagctg gttcctgggc agcgttcaga tccgtgtgcc ccgtcaaggc     1500

aagcagtaca cctttcccgc caaccgctgg ctggacaaga accaggctga cgggcgcctg     1560

gaggtggagc tgtatcccag cgaggtggtg gagatccaga aattggtcca ctatgaggtt     1620

gagatttgga caggagatgt gggtggcgca ggcaccagtg cccgagtcta catgcagatc     1680

tatggagaga aaggcaagac agaagtgctc ttcctctcca gccgctcaaa agtttttgaa     1740

cgggcgtcca aggacacatt ccagcttgag gcggccgacg tgggcgaggt ctataagctc     1800

cggctcgggc acacgggcga gggctttggg cccagctggt tcgtggacac cgtgtggctg     1860

cggcacctgg tggtgcggga ggtggacctc acgccggagg aggaggcccg gaagaagaag     1920

gagaaggaca agctgcggca gctgctcaag aaggagcggc tgaaggccaa gctgcagagg     1980

aagaagaaga agaggaaggg cagcgacgaa gaggacgagg gggaggaaga ggagtcgtcc     2040

tcatcagagg agtcctcgtc agaggaggag gagatggaag aagaggagga agaggaggag     2100

tttgggccgg ggatgcagga ggtgattgag cagcacaagt tcgaagccca ccgctggctg     2160

gcccggggca aggaggacaa cgaacttgtc gtggagttgg tgccagctgg caagccgggt     2220

cctgagcgaa acacctatga ggttcaggtg gtcacgggga atgtgcccaa ggccggcact     2280

gatgctaacg tctacctaac catctacggc gaggagtatg gagacacggg cgaacgaccc     2340

ctgaagaagt cagacaagtc caacaaattt gagcaggggc agacagacac cttcaccatc     2400

tatgccattg acctgggggc cctgaccaag attcggattc gccacgacaa cacaggcaac     2460

agagcaggct ggttcctgga cagaatagac attactgaca tgaacaacga gatcacgtac     2520

tactttccat gccaacgttg gctggcagtg gaggaagatg atggccagct gtccagggag     2580

ctgttgccag tggatgagtc ctatgtgctg ccacagagcg aggagggtag gggaggcggt     2640

gacaacaacc ccctcgacaa cctggccctg gagcagaaag ataaatctac cacattctca     2700

gtgaccataa agactggggt taagaagaat gcgggcacag atgctaatgt cttcatcaca     2760

ctctttggca cacaggatga cactggaatg accctcctga agtcctccaa gacaaacagc     2820

gataagtttg agagggacag cattgaaatc ttcacggtgg agacgctgga tctgggagac     2880

ctgtggaaag tccggcttgg ccatgacaac acaggcaagg ccccaggctg gtttgtagac     2940

tgggtagagg tggatgcccc atctcttggg aagtgcatga cgtttccctg tggccgctgg     3000

ctggccaaaa acgaagacga cgggtccatc atcagagacc tcttccatgc agagcttcag     3060

acgaggctgt acacaccatt tgttccttac gagatcaccc tctacaccag tgatgtcttt     3120

gctgctggga cagatgccaa catcttcatc atcatctatg gctgcgatgc cgtgtgcacc     3180

cagcagaagt atctgtgtac caacaagagg gaacagaagc agttctttga gaggaagtct     3240

gcctcccgct tcatcgtaga gttagaagat gtgggagaaa tcattgaaaa aattcggatt     3300

ggccataata acacgggcat gaatcctggg tggcactgct ctcacgtgga catccgcagg     3360

ctcctcccgg ataaagacgg tgcagagacc ttgactttcc catgcgatcg gtggcttgcc     3420

acctctgagg atgacaaaaa gaccattcga gaactggttc catatgacat cttcactgag     3480

aaatacatga aagatgggtc cttacggcaa gtctacaagg aagtagaaga gcctctggac     3540

attgtgctgt actcggtgca gatcttcaca gggaacattc ctggggcagg gacggatgcc     3600

aaggtgtaca tcaccatcta tggagacctc ggggacactg gggagcgata ccttggcaag     3660

tcagagaacc ggaccaacaa gttcgagaga ggaacggctg acaccttcat catcgaggcc     3720

gctgacctag gcgtcatcta caagatcaag ctccgccatg acaactccaa gtggtgcgca     3780

gactggtacg tggagaaggt ggagatctgg aatgacacca acgaggacga gttcctgttc     3840

ctatgcgggc gctggctctc cctgaagaag gaggatgggc gactcgagag gctcttttac     3900

gagaaggagt acactgggga ccgcagcagc aactgcagca gccctgctga cttctgggag     3960

atcgccctga gctccaagat ggccgatgtc gacatcagca cagtgaccgg gcccatggct     4020

gactacgttc aagagggccc aattattccc tactatgtgt cagtcaccac tgggaagcac     4080

aaggacgcgg ccactgacag ccgagccttc atctttctca tcggggagga tgatgaacgt     4140

agtaagcgca tctggttgga ctacccccga gggaagaggg gcttcagccg tggctctgtg     4200

gaggagttct acgtcgcagg cttggatgtg ggcatcatca agaaaataga gctgggccat     4260

gacggggcct cccctgagag ctgctggctg gtggaagagt tgtgtttggc agtgcccacc     4320

cagggcacca agtacatgtt gaactgtaac tgctggctgg ccaaggacag aggcgacggc     4380

atcacctccc gtgtcttcga cctcttggat gccatggtgg tgaacattgg ggtgaaggtt     4440

ctctatgaaa tgacggtgtg gacaggggat gtggttggcg ggggcactga ctccaacatc     4500

ttcatgaccc tctacggcat caacgggagc acagaggaga tgcagctgga caaaaagaaa     4560

gccaggtttg agcgggagca gaacgacacc ttcatcatgg agatcctaga cattgctcca     4620

ttcaccaaga tgcggatccg gattgatggc ctgggcagtc ggccggagtg gttcctggag     4680

aggatcctac tgaagaacat gaacactgga gacctgacca tgttctacta tggagactgg     4740

ctgtcccagc ggaagggcaa gaagaccctg gtgtgtgaaa tgtgtgccgt tatcgatgag     4800

gaagaaatga tggagtggac ctcctacacc gtcgcagtta agaccagcga catcctggga     4860

gcaggcactg atgccaacgt gttcatcatc atcttcgggg agaacgggga tagtgggaca     4920

ctggccctga agcagtcggc aaactggaac aagtttgagc ggaacaacac ggacacattc     4980

aacttccctg acatgctgag cttgggccac ctctgcaagc tgagggtctg gcacgacaac     5040

aaagggatat ttcctggctg gcatctgagc tatgtcgatg tgaaggacaa ctcccgcgac     5100

gagaccttcc acttccagtg tgactgctgg ctctccaaga gtgagggtga cgggcagacg     5160

gtccgcgact ttgcctgtgc caacaacaag atctgtgatg agctggaaga gaccacctac     5220

gagatcgtca tagaaacggg caacggaggc gaaaccaggg agaacgtctg gctcatcctg     5280

gagggcagga agaaccgatc caaagagttt ctcatggaaa attcttctag gcagcgggcc     5340

tttaggaagg ggaccacaga cacgtttgag tttgacagca tctacttggg ggacattgcc     5400

tccctctgtg tgggccacct tgccagggaa gaccggttta tccccaagag agaacttgcc     5460

tggcatgtca agaccatcac catcaccgag atggagtacg gcaatgtgta cttctttaac     5520

tgtgactgcc tcatccccct caagaggaag aggaagtact tcaaggtatt cgaggttacc     5580

aagacgacag agagctttgc cagcaaggtc cagagcctgg tgcccgtcaa gtacgaagtc     5640

atcgtgacaa caggctatga gccaggggca ggcactgatg ccaacgtctt cgtgaccatc     5700

tttggggcca acggagacac aggcaagcgg gagctgaagc agaaaatgcg caacctcttc     5760

gagcggggca gcacagaccg cttcttcctg gagacgctgg agctggtagt gaccaggctg     5820

ggacttgctg cagagtgtgg atga                                            5844


<210>  604
<211>  1947
<212>  PRT
<213>  Homo sapiens

<400>  604

Met Met Gln Leu Thr Leu Asn Thr Leu Phe Pro Val Val Ser Thr Pro 
1               5                   10                  15      


Ala Ile Thr Tyr Ile Val Thr Val Phe Thr Gly Asp Val Arg Gly Ala 
            20                  25                  30          


Gly Thr Lys Ser Lys Ile Tyr Leu Val Met Tyr Gly Ala Arg Gly Asn 
        35                  40                  45              


Lys Asn Ser Gly Lys Ile Phe Leu Glu Gly Gly Val Phe Asp Arg Gly 
    50                  55                  60                  


Arg Thr Asp Ile Phe His Ile Glu Leu Ala Val Leu Leu Ser Pro Leu 
65                  70                  75                  80  


Ser Arg Val Ser Val Gly His Gly Asn Val Gly Val Asn Arg Gly Trp 
                85                  90                  95      


Phe Cys Glu Lys Val Val Ile Leu Cys Pro Phe Thr Gly Ile Gln Gln 
            100                 105                 110         


Thr Phe Pro Cys Ser Asn Trp Leu Asp Glu Lys Lys Ala Asp Gly Leu 
        115                 120                 125             


Ile Glu Arg Gln Leu Tyr Glu Met Val Ser Leu Arg Lys Lys Arg Leu 
    130                 135                 140                 


Lys Lys Phe Pro Trp Ser Leu Trp Val Trp Thr Thr Asp Leu Lys Lys 
145                 150                 155                 160 


Ala Gly Thr Asn Ser Pro Ile Phe Ile Gln Ile Tyr Gly Gln Lys Gly 
                165                 170                 175     


Arg Thr Asp Glu Ile Leu Leu Asn Pro Asn Asn Lys Trp Phe Lys Pro 
            180                 185                 190         


Gly Ile Ile Glu Lys Phe Arg Ile Glu Leu Pro Asp Leu Gly Arg Phe 
        195                 200                 205             


Tyr Lys Ile Arg Val Trp His Asp Lys Arg Ser Ser Gly Ser Gly Trp 
    210                 215                 220                 


His Leu Glu Arg Met Thr Leu Met Asn Thr Leu Asn Lys Asp Lys Tyr 
225                 230                 235                 240 


Asn Phe Asn Cys Asn Arg Trp Leu Asp Ala Asn Glu Asp Asp Asn Glu 
                245                 250                 255     


Ile Val Arg Glu Met Thr Ala Glu Gly Pro Thr Val Arg Arg Ile Met 
            260                 265                 270         


Gly Met Ala Arg Tyr His Val Thr Val Cys Thr Gly Glu Leu Glu Gly 
        275                 280                 285             


Ala Gly Thr Asp Ala Asn Val Tyr Leu Cys Leu Phe Gly Asp Val Gly 
    290                 295                 300                 


Asp Thr Gly Glu Arg Leu Leu Tyr Asn Cys Arg Asn Asn Thr Asp Leu 
305                 310                 315                 320 


Phe Glu Lys Gly Asn Ala Asp Glu Phe Thr Ile Glu Ser Val Thr Met 
                325                 330                 335     


Arg Asn Val Arg Arg Val Arg Ile Arg His Asp Gly Lys Gly Ser Gly 
            340                 345                 350         


Ser Gly Trp Tyr Leu Asp Arg Val Leu Val Arg Glu Glu Gly Gln Pro 
        355                 360                 365             


Glu Ser Asp Asn Val Glu Phe Pro Cys Leu Arg Trp Leu Asp Lys Asp 
    370                 375                 380                 


Lys Asp Asp Gly Gln Leu Val Arg Glu Leu Leu Pro Ser Asp Ser Ser 
385                 390                 395                 400 


Ala Thr Leu Lys Asn Phe Arg Tyr His Ile Ser Leu Lys Thr Gly Asp 
                405                 410                 415     


Val Ser Gly Ala Ser Thr Asp Ser Arg Val Tyr Ile Lys Leu Tyr Gly 
            420                 425                 430         


Asp Lys Ser Asp Thr Ile Lys Gln Val Leu Leu Val Ser Asp Asn Asn 
        435                 440                 445             


Leu Lys Asp Tyr Phe Glu Arg Gly Arg Val Asp Glu Phe Thr Leu Glu 
    450                 455                 460                 


Thr Leu Asn Ile Gly Asn Ile Asn Arg Leu Val Ile Gly His Asp Ser 
465                 470                 475                 480 


Thr Gly Met His Ala Ser Trp Phe Leu Gly Ser Val Gln Ile Arg Val 
                485                 490                 495     


Pro Arg Gln Gly Lys Gln Tyr Thr Phe Pro Ala Asn Arg Trp Leu Asp 
            500                 505                 510         


Lys Asn Gln Ala Asp Gly Arg Leu Glu Val Glu Leu Tyr Pro Ser Glu 
        515                 520                 525             


Val Val Glu Ile Gln Lys Leu Val His Tyr Glu Val Glu Ile Trp Thr 
    530                 535                 540                 


Gly Asp Val Gly Gly Ala Gly Thr Ser Ala Arg Val Tyr Met Gln Ile 
545                 550                 555                 560 


Tyr Gly Glu Lys Gly Lys Thr Glu Val Leu Phe Leu Ser Ser Arg Ser 
                565                 570                 575     


Lys Val Phe Glu Arg Ala Ser Lys Asp Thr Phe Gln Leu Glu Ala Ala 
            580                 585                 590         


Asp Val Gly Glu Val Tyr Lys Leu Arg Leu Gly His Thr Gly Glu Gly 
        595                 600                 605             


Phe Gly Pro Ser Trp Phe Val Asp Thr Val Trp Leu Arg His Leu Val 
    610                 615                 620                 


Val Arg Glu Val Asp Leu Thr Pro Glu Glu Glu Ala Arg Lys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Lys Leu Arg Gln Leu Leu Lys Lys Glu Arg Leu Lys Ala 
                645                 650                 655     


Lys Leu Gln Arg Lys Lys Lys Lys Arg Lys Gly Ser Asp Glu Glu Asp 
            660                 665                 670         


Glu Gly Glu Glu Glu Glu Ser Ser Ser Ser Glu Glu Ser Ser Ser Glu 
        675                 680                 685             


Glu Glu Glu Met Glu Glu Glu Glu Glu Glu Glu Glu Phe Gly Pro Gly 
    690                 695                 700                 


Met Gln Glu Val Ile Glu Gln His Lys Phe Glu Ala His Arg Trp Leu 
705                 710                 715                 720 


Ala Arg Gly Lys Glu Asp Asn Glu Leu Val Val Glu Leu Val Pro Ala 
                725                 730                 735     


Gly Lys Pro Gly Pro Glu Arg Asn Thr Tyr Glu Val Gln Val Val Thr 
            740                 745                 750         


Gly Asn Val Pro Lys Ala Gly Thr Asp Ala Asn Val Tyr Leu Thr Ile 
        755                 760                 765             


Tyr Gly Glu Glu Tyr Gly Asp Thr Gly Glu Arg Pro Leu Lys Lys Ser 
    770                 775                 780                 


Asp Lys Ser Asn Lys Phe Glu Gln Gly Gln Thr Asp Thr Phe Thr Ile 
785                 790                 795                 800 


Tyr Ala Ile Asp Leu Gly Ala Leu Thr Lys Ile Arg Ile Arg His Asp 
                805                 810                 815     


Asn Thr Gly Asn Arg Ala Gly Trp Phe Leu Asp Arg Ile Asp Ile Thr 
            820                 825                 830         


Asp Met Asn Asn Glu Ile Thr Tyr Tyr Phe Pro Cys Gln Arg Trp Leu 
        835                 840                 845             


Ala Val Glu Glu Asp Asp Gly Gln Leu Ser Arg Glu Leu Leu Pro Val 
    850                 855                 860                 


Asp Glu Ser Tyr Val Leu Pro Gln Ser Glu Glu Gly Arg Gly Gly Gly 
865                 870                 875                 880 


Asp Asn Asn Pro Leu Asp Asn Leu Ala Leu Glu Gln Lys Asp Lys Ser 
                885                 890                 895     


Thr Thr Phe Ser Val Thr Ile Lys Thr Gly Val Lys Lys Asn Ala Gly 
            900                 905                 910         


Thr Asp Ala Asn Val Phe Ile Thr Leu Phe Gly Thr Gln Asp Asp Thr 
        915                 920                 925             


Gly Met Thr Leu Leu Lys Ser Ser Lys Thr Asn Ser Asp Lys Phe Glu 
    930                 935                 940                 


Arg Asp Ser Ile Glu Ile Phe Thr Val Glu Thr Leu Asp Leu Gly Asp 
945                 950                 955                 960 


Leu Trp Lys Val Arg Leu Gly His Asp Asn Thr Gly Lys Ala Pro Gly 
                965                 970                 975     


Trp Phe Val Asp Trp Val Glu Val Asp Ala Pro Ser Leu Gly Lys Cys 
            980                 985                 990         


Met Thr Phe Pro Cys Gly Arg Trp  Leu Ala Lys Asn Glu  Asp Asp Gly 
        995                 1000                 1005             


Ser Ile  Ile Arg Asp Leu Phe  His Ala Glu Leu Gln  Thr Arg Leu 
    1010                 1015                 1020             


Tyr Thr  Pro Phe Val Pro Tyr  Glu Ile Thr Leu Tyr  Thr Ser Asp 
    1025                 1030                 1035             


Val Phe  Ala Ala Gly Thr Asp  Ala Asn Ile Phe Ile  Ile Ile Tyr 
    1040                 1045                 1050             


Gly Cys  Asp Ala Val Cys Thr  Gln Gln Lys Tyr Leu  Cys Thr Asn 
    1055                 1060                 1065             


Lys Arg  Glu Gln Lys Gln Phe  Phe Glu Arg Lys Ser  Ala Ser Arg 
    1070                 1075                 1080             


Phe Ile  Val Glu Leu Glu Asp  Val Gly Glu Ile Ile  Glu Lys Ile 
    1085                 1090                 1095             


Arg Ile  Gly His Asn Asn Thr  Gly Met Asn Pro Gly  Trp His Cys 
    1100                 1105                 1110             


Ser His  Val Asp Ile Arg Arg  Leu Leu Pro Asp Lys  Asp Gly Ala 
    1115                 1120                 1125             


Glu Thr  Leu Thr Phe Pro Cys  Asp Arg Trp Leu Ala  Thr Ser Glu 
    1130                 1135                 1140             


Asp Asp  Lys Lys Thr Ile Arg  Glu Leu Val Pro Tyr  Asp Ile Phe 
    1145                 1150                 1155             


Thr Glu  Lys Tyr Met Lys Asp  Gly Ser Leu Arg Gln  Val Tyr Lys 
    1160                 1165                 1170             


Glu Val  Glu Glu Pro Leu Asp  Ile Val Leu Tyr Ser  Val Gln Ile 
    1175                 1180                 1185             


Phe Thr  Gly Asn Ile Pro Gly  Ala Gly Thr Asp Ala  Lys Val Tyr 
    1190                 1195                 1200             


Ile Thr  Ile Tyr Gly Asp Leu  Gly Asp Thr Gly Glu  Arg Tyr Leu 
    1205                 1210                 1215             


Gly Lys  Ser Glu Asn Arg Thr  Asn Lys Phe Glu Arg  Gly Thr Ala 
    1220                 1225                 1230             


Asp Thr  Phe Ile Ile Glu Ala  Ala Asp Leu Gly Val  Ile Tyr Lys 
    1235                 1240                 1245             


Ile Lys  Leu Arg His Asp Asn  Ser Lys Trp Cys Ala  Asp Trp Tyr 
    1250                 1255                 1260             


Val Glu  Lys Val Glu Ile Trp  Asn Asp Thr Asn Glu  Asp Glu Phe 
    1265                 1270                 1275             


Leu Phe  Leu Cys Gly Arg Trp  Leu Ser Leu Lys Lys  Glu Asp Gly 
    1280                 1285                 1290             


Arg Leu  Glu Arg Leu Phe Tyr  Glu Lys Glu Tyr Thr  Gly Asp Arg 
    1295                 1300                 1305             


Ser Ser  Asn Cys Ser Ser Pro  Ala Asp Phe Trp Glu  Ile Ala Leu 
    1310                 1315                 1320             


Ser Ser  Lys Met Ala Asp Val  Asp Ile Ser Thr Val  Thr Gly Pro 
    1325                 1330                 1335             


Met Ala  Asp Tyr Val Gln Glu  Gly Pro Ile Ile Pro  Tyr Tyr Val 
    1340                 1345                 1350             


Ser Val  Thr Thr Gly Lys His  Lys Asp Ala Ala Thr  Asp Ser Arg 
    1355                 1360                 1365             


Ala Phe  Ile Phe Leu Ile Gly  Glu Asp Asp Glu Arg  Ser Lys Arg 
    1370                 1375                 1380             


Ile Trp  Leu Asp Tyr Pro Arg  Gly Lys Arg Gly Phe  Ser Arg Gly 
    1385                 1390                 1395             


Ser Val  Glu Glu Phe Tyr Val  Ala Gly Leu Asp Val  Gly Ile Ile 
    1400                 1405                 1410             


Lys Lys  Ile Glu Leu Gly His  Asp Gly Ala Ser Pro  Glu Ser Cys 
    1415                 1420                 1425             


Trp Leu  Val Glu Glu Leu Cys  Leu Ala Val Pro Thr  Gln Gly Thr 
    1430                 1435                 1440             


Lys Tyr  Met Leu Asn Cys Asn  Cys Trp Leu Ala Lys  Asp Arg Gly 
    1445                 1450                 1455             


Asp Gly  Ile Thr Ser Arg Val  Phe Asp Leu Leu Asp  Ala Met Val 
    1460                 1465                 1470             


Val Asn  Ile Gly Val Lys Val  Leu Tyr Glu Met Thr  Val Trp Thr 
    1475                 1480                 1485             


Gly Asp  Val Val Gly Gly Gly  Thr Asp Ser Asn Ile  Phe Met Thr 
    1490                 1495                 1500             


Leu Tyr  Gly Ile Asn Gly Ser  Thr Glu Glu Met Gln  Leu Asp Lys 
    1505                 1510                 1515             


Lys Lys  Ala Arg Phe Glu Arg  Glu Gln Asn Asp Thr  Phe Ile Met 
    1520                 1525                 1530             


Glu Ile  Leu Asp Ile Ala Pro  Phe Thr Lys Met Arg  Ile Arg Ile 
    1535                 1540                 1545             


Asp Gly  Leu Gly Ser Arg Pro  Glu Trp Phe Leu Glu  Arg Ile Leu 
    1550                 1555                 1560             


Leu Lys  Asn Met Asn Thr Gly  Asp Leu Thr Met Phe  Tyr Tyr Gly 
    1565                 1570                 1575             


Asp Trp  Leu Ser Gln Arg Lys  Gly Lys Lys Thr Leu  Val Cys Glu 
    1580                 1585                 1590             


Met Cys  Ala Val Ile Asp Glu  Glu Glu Met Met Glu  Trp Thr Ser 
    1595                 1600                 1605             


Tyr Thr  Val Ala Val Lys Thr  Ser Asp Ile Leu Gly  Ala Gly Thr 
    1610                 1615                 1620             


Asp Ala  Asn Val Phe Ile Ile  Ile Phe Gly Glu Asn  Gly Asp Ser 
    1625                 1630                 1635             


Gly Thr  Leu Ala Leu Lys Gln  Ser Ala Asn Trp Asn  Lys Phe Glu 
    1640                 1645                 1650             


Arg Asn  Asn Thr Asp Thr Phe  Asn Phe Pro Asp Met  Leu Ser Leu 
    1655                 1660                 1665             


Gly His  Leu Cys Lys Leu Arg  Val Trp His Asp Asn  Lys Gly Ile 
    1670                 1675                 1680             


Phe Pro  Gly Trp His Leu Ser  Tyr Val Asp Val Lys  Asp Asn Ser 
    1685                 1690                 1695             


Arg Asp  Glu Thr Phe His Phe  Gln Cys Asp Cys Trp  Leu Ser Lys 
    1700                 1705                 1710             


Ser Glu  Gly Asp Gly Gln Thr  Val Arg Asp Phe Ala  Cys Ala Asn 
    1715                 1720                 1725             


Asn Lys  Ile Cys Asp Glu Leu  Glu Glu Thr Thr Tyr  Glu Ile Val 
    1730                 1735                 1740             


Ile Glu  Thr Gly Asn Gly Gly  Glu Thr Arg Glu Asn  Val Trp Leu 
    1745                 1750                 1755             


Ile Leu  Glu Gly Arg Lys Asn  Arg Ser Lys Glu Phe  Leu Met Glu 
    1760                 1765                 1770             


Asn Ser  Ser Arg Gln Arg Ala  Phe Arg Lys Gly Thr  Thr Asp Thr 
    1775                 1780                 1785             


Phe Glu  Phe Asp Ser Ile Tyr  Leu Gly Asp Ile Ala  Ser Leu Cys 
    1790                 1795                 1800             


Val Gly  His Leu Ala Arg Glu  Asp Arg Phe Ile Pro  Lys Arg Glu 
    1805                 1810                 1815             


Leu Ala  Trp His Val Lys Thr  Ile Thr Ile Thr Glu  Met Glu Tyr 
    1820                 1825                 1830             


Gly Asn  Val Tyr Phe Phe Asn  Cys Asp Cys Leu Ile  Pro Leu Lys 
    1835                 1840                 1845             


Arg Lys  Arg Lys Tyr Phe Lys  Val Phe Glu Val Thr  Lys Thr Thr 
    1850                 1855                 1860             


Glu Ser  Phe Ala Ser Lys Val  Gln Ser Leu Val Pro  Val Lys Tyr 
    1865                 1870                 1875             


Glu Val  Ile Val Thr Thr Gly  Tyr Glu Pro Gly Ala  Gly Thr Asp 
    1880                 1885                 1890             


Ala Asn  Val Phe Val Thr Ile  Phe Gly Ala Asn Gly  Asp Thr Gly 
    1895                 1900                 1905             


Lys Arg  Glu Leu Lys Gln Lys  Met Arg Asn Leu Phe  Glu Arg Gly 
    1910                 1915                 1920             


Ser Thr  Asp Arg Phe Phe Leu  Glu Thr Leu Glu Leu  Val Val Thr 
    1925                 1930                 1935             


Arg Leu  Gly Leu Ala Ala Glu  Cys Gly 
    1940                 1945         


<210>  605
<211>  1281
<212>  DNA
<213>  Homo sapiens

<400>  605
atggccaatg acagcggcgg gcccggcggg ccgagcccga gcgagcgaga ccggcagtac       60

tgcgagctgt gcgggaagat ggagaacctg ctgcgctgca gccgctgccg cagctccttc      120

tactgctgca aggagcacca gcgtcaggac tggaagaagc acaagctcgt gtgccagggc      180

agcgagggcg ccctcggcca cggagtgggc ccacaccagc attccggccc cgcgccgccg      240

gctgcagtgc cgccgcccag ggccggggcc cgggagccca ggaaggcagc ggcgcgccgg      300

gacaacgcct ccggggacgc ggccaaggga aaagtaaagg ccaagccccc ggccgaccca      360

gcggcggccg cgtcgccgtg tcgtgcggcc gccggcggcc agggctcggc ggtggctgcc      420

gaagccgagc ccggcaagga ggagccgccg gcccgctcat cgctgttcca ggagaaggcg      480

aacctgtacc ccccaagcaa cacgcccggg gatgcgctga gccccggcgg cggcctgcgg      540

cccaacgggc agacgaagcc cctgccggcg ctgaagctgg cgctcgagta catcgtgccg      600

tgcatgaaca agcacggcat ctgtgtggtg gacgacttcc tcggcaagga gaccggacag      660

cagatcggcg acgaggtgcg cgccctgcac gacaccggga agttcacgga cgggcagctg      720

gtcagccaga agagtgactc gtccaaggac atccgaggcg ataagatcac ctggatcgag      780

ggcaaggagc ccggctgcga aaccattggg ctgctcatga gcagcatgga cgacctgata      840

cgccactgta acgggaagct gggcagctac aaaatcaatg gccggacgaa agccatggtt      900

gcttgttatc cgggcaatgg aacgggttat gtacgtcatg ttgataatcc aaatggagat      960

ggaagatgtg tgacatgtat atattatctt aataaagact gggatgccaa ggtaagtgga     1020

ggtatacttc gaatttttcc agaaggcaaa gcccagtttg ctgacattga acccaaattt     1080

gatagactgc tgtttttctg gtctgaccgt cgcaaccctc atgaagtaca accagcatat     1140

gctacaaggt acgcaataac tgtttggtat tttgatgcag atgagagagc acgagctaaa     1200

gtaaaatatc taacaggtga aaaaggtgtg agggttgaac tcaataaacc ttcagattcg     1260

gtcggtaaag acgtcttcta g                                               1281


<210>  606
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Ser Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ala Gln 
            340                 345                 350         


Phe Ala Asp Ile Glu Pro Lys Phe Asp Arg Leu Leu Phe Phe Trp Ser 
        355                 360                 365             


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ala Tyr Ala Thr Arg Tyr 
    370                 375                 380                 


Ala Ile Thr Val Trp Tyr Phe Asp Ala Asp Glu Arg Ala Arg Ala Lys 
385                 390                 395                 400 


Val Lys Tyr Leu Thr Gly Glu Lys Gly Val Arg Val Glu Leu Asn Lys 
                405                 410                 415     


Pro Ser Asp Ser Val Gly Lys Asp Val Phe 
            420                 425     


<210>  607
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  607
atgagcctca gacttgatac caccccttcc tgtaacagtg cgagaccact tcatgccttg       60

caggtgctgc tgcttctgtc attgctgctg actgctctgg cttcctccac caaaggacaa      120

actaagagaa acttggcgaa aggcaaagag gaaagtctag acagtgactt gtatgctgaa      180

ctccgctgca tgtgtataaa gacaacctct ggaattcatc ccaaaaacat ccaaagtttg      240

gaagtgatcg ggaaaggaac ccattgcaac caagtcgaag tgatagccac actgaaggat      300

gggaggaaaa tctgcctgga cccagatgct cccagaatca agaaaattgt acagaaaaaa      360

ttggcaggtg atgaatctgc tgattaa                                          387


<210>  608
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             


<210>  609
<211>  2226
<212>  DNA
<213>  Homo sapiens

<400>  609
atggcagaac ctgtttctcc actgaagcac tttgtgctgg ctaagaaggc gattactgca       60

atctttgacc agttactgga gtttgttact gaaggatcac attttgttga agcaacatat      120

aagaatccgg aacttgatcg aatagccact gaagatgatc tggtagaaat gcaaggatat      180

aaagacaagc tttccatcat tggtgaggtg ctatctcgga gacacatgaa ggtggcattt      240

tttggcagga caagcagtgg gaagagctct gttatcaatg caatgttgtg ggataaagtt      300

ctccctagtg ggattggcca tataaccaat tgcttcctaa gtgttgaagg aactgatgga      360

gataaagcct atcttatgac agaaggatca gatgaaaaaa agagtgtgaa gacagttaat      420

caactggccc atgcccttca catggacaaa gatttgaaag ctggctgtct tgtacgtgtg      480

ttttggccaa aagcaaaatg tgccctcttg agagatgacc tggtgttagt agacagtcca      540

ggcacagatg tcactacaga gctggatagc tggattgata agttttgcct agatgctgat      600

gtctttgttt tggtcgcaaa ctctgaatca acactaatga atacggaaaa acactttttt      660

cacaaggtga atgagcggct ttccaagcct aatattttca ttctcaataa tcgttgggat      720

gcctctgcat cagagccaga atatatggaa gacgtacgca gacagcacat ggaaagatgc      780

ctgcatttct tggtggagga gctcaaagtt gtaaatgctt tagaagcaca gaatcgtatc      840

ttctttgttt cagcaaagga agttcttagt gctagaaagc aaaaagcaca ggggatgcca      900

gaaagtggtg tggcacttgc tgaaggattt catgcaagat tacaggaatt tcagaatttt      960

gaacaaatct ttgaggagtg tatctcgcag tcagcagtga aaacaaagtt cgaacagcac     1020

actatcagag ctaaacagat actagctact gtgaaaaaca taatggattc agtaaacctg     1080

gcagctgaag ataaaaggca ttattcagtg gaagagaggg aagaccaaat tgatagactg     1140

gactttattc gaaaccagat gaacctttta acactggatg ttaagaaaaa aatcaaggag     1200

gttaccgagg aggtggcaaa caaagtttca tgtgcaatga cagatgaaat ttgtcgactg     1260

tctgttttgg ttgatgaatt ttgttcagag tttcatccta atccagatgt attaaaaata     1320

tataaaagtg aattaaataa gcacatagag gatggtatgg gaagaaattt ggctgatcga     1380

tgcaccgatg aagtaaacgc cttagtgctt cagacccagc aagaaattat tgaaaatttg     1440

aagccattac ttccagctgg tatacaggat aaactacata cactgatccc ttgcaagaaa     1500

tttgatctca gttataatct aaattaccac aagttatgtt cagattttca agaggatatt     1560

gtatttcctt tttccctggg ctggtcttcc cttgtacatc gatttttggg ccctagaaat     1620

gctcaaaggg tgctcctagg attatcagag cctatctttc agctccctag atctttagct     1680

tctactccca ctgctcctac cactccagca acgccagata atgcatcaca ggaagaactc     1740

atgattacat tagtaacagg attggcgtcc gttacatcta gaacttctat gggcatcatt     1800

attgttggag gagtgatttg gaaaactata ggctggaaac tcctatctgt ttcattaact     1860

atgtatggag ctttgtatct ttatgaaaga ctgagctgga ccacccatgc caaggagcga     1920

gcctttaaac agcagtttgt aaactatgca actgaaaaac tgaggatgat tgttagctcc     1980

acgagtgcaa actgcagtca ccaagtaaaa caacaaatag ctaccacttt tgctcgcctg     2040

tgccaacaag ttgatattac tcaaaaacag ctggaagaag aaattgctag attacccaaa     2100

gaaatagatc agttggagaa aatacaaaac aattcaaagc tcttaagaaa taaagctgtt     2160

caacttgaaa atgagctgga gaattttact aagcagtttc taccttcaag caatgaagaa     2220

tcctaa                                                                2226


<210>  610
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  610

Met Ala Glu Pro Val Ser Pro Leu Lys His Phe Val Leu Ala Lys Lys 
1               5                   10                  15      


Ala Ile Thr Ala Ile Phe Asp Gln Leu Leu Glu Phe Val Thr Glu Gly 
            20                  25                  30          


Ser His Phe Val Glu Ala Thr Tyr Lys Asn Pro Glu Leu Asp Arg Ile 
        35                  40                  45              


Ala Thr Glu Asp Asp Leu Val Glu Met Gln Gly Tyr Lys Asp Lys Leu 
    50                  55                  60                  


Ser Ile Ile Gly Glu Val Leu Ser Arg Arg His Met Lys Val Ala Phe 
65                  70                  75                  80  


Phe Gly Arg Thr Ser Ser Gly Lys Ser Ser Val Ile Asn Ala Met Leu 
                85                  90                  95      


Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His Ile Thr Asn Cys Phe 
            100                 105                 110         


Leu Ser Val Glu Gly Thr Asp Gly Asp Lys Ala Tyr Leu Met Thr Glu 
        115                 120                 125             


Gly Ser Asp Glu Lys Lys Ser Val Lys Thr Val Asn Gln Leu Ala His 
    130                 135                 140                 


Ala Leu His Met Asp Lys Asp Leu Lys Ala Gly Cys Leu Val Arg Val 
145                 150                 155                 160 


Phe Trp Pro Lys Ala Lys Cys Ala Leu Leu Arg Asp Asp Leu Val Leu 
                165                 170                 175     


Val Asp Ser Pro Gly Thr Asp Val Thr Thr Glu Leu Asp Ser Trp Ile 
            180                 185                 190         


Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val Leu Val Ala Asn Ser 
        195                 200                 205             


Glu Ser Thr Leu Met Asn Thr Glu Lys His Phe Phe His Lys Val Asn 
    210                 215                 220                 


Glu Arg Leu Ser Lys Pro Asn Ile Phe Ile Leu Asn Asn Arg Trp Asp 
225                 230                 235                 240 


Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Asp Val Arg Arg Gln His 
                245                 250                 255     


Met Glu Arg Cys Leu His Phe Leu Val Glu Glu Leu Lys Val Val Asn 
            260                 265                 270         


Ala Leu Glu Ala Gln Asn Arg Ile Phe Phe Val Ser Ala Lys Glu Val 
        275                 280                 285             


Leu Ser Ala Arg Lys Gln Lys Ala Gln Gly Met Pro Glu Ser Gly Val 
    290                 295                 300                 


Ala Leu Ala Glu Gly Phe His Ala Arg Leu Gln Glu Phe Gln Asn Phe 
305                 310                 315                 320 


Glu Gln Ile Phe Glu Glu Cys Ile Ser Gln Ser Ala Val Lys Thr Lys 
                325                 330                 335     


Phe Glu Gln His Thr Ile Arg Ala Lys Gln Ile Leu Ala Thr Val Lys 
            340                 345                 350         


Asn Ile Met Asp Ser Val Asn Leu Ala Ala Glu Asp Lys Arg His Tyr 
        355                 360                 365             


Ser Val Glu Glu Arg Glu Asp Gln Ile Asp Arg Leu Asp Phe Ile Arg 
    370                 375                 380                 


Asn Gln Met Asn Leu Leu Thr Leu Asp Val Lys Lys Lys Ile Lys Glu 
385                 390                 395                 400 


Val Thr Glu Glu Val Ala Asn Lys Val Ser Cys Ala Met Thr Asp Glu 
                405                 410                 415     


Ile Cys Arg Leu Ser Val Leu Val Asp Glu Phe Cys Ser Glu Phe His 
            420                 425                 430         


Pro Asn Pro Asp Val Leu Lys Ile Tyr Lys Ser Glu Leu Asn Lys His 
        435                 440                 445             


Ile Glu Asp Gly Met Gly Arg Asn Leu Ala Asp Arg Cys Thr Asp Glu 
    450                 455                 460                 


Val Asn Ala Leu Val Leu Gln Thr Gln Gln Glu Ile Ile Glu Asn Leu 
465                 470                 475                 480 


Lys Pro Leu Leu Pro Ala Gly Ile Gln Asp Lys Leu His Thr Leu Ile 
                485                 490                 495     


Pro Cys Lys Lys Phe Asp Leu Ser Tyr Asn Leu Asn Tyr His Lys Leu 
            500                 505                 510         


Cys Ser Asp Phe Gln Glu Asp Ile Val Phe Pro Phe Ser Leu Gly Trp 
        515                 520                 525             


Ser Ser Leu Val His Arg Phe Leu Gly Pro Arg Asn Ala Gln Arg Val 
    530                 535                 540                 


Leu Leu Gly Leu Ser Glu Pro Ile Phe Gln Leu Pro Arg Ser Leu Ala 
545                 550                 555                 560 


Ser Thr Pro Thr Ala Pro Thr Thr Pro Ala Thr Pro Asp Asn Ala Ser 
                565                 570                 575     


Gln Glu Glu Leu Met Ile Thr Leu Val Thr Gly Leu Ala Ser Val Thr 
            580                 585                 590         


Ser Arg Thr Ser Met Gly Ile Ile Ile Val Gly Gly Val Ile Trp Lys 
        595                 600                 605             


Thr Ile Gly Trp Lys Leu Leu Ser Val Ser Leu Thr Met Tyr Gly Ala 
    610                 615                 620                 


Leu Tyr Leu Tyr Glu Arg Leu Ser Trp Thr Thr His Ala Lys Glu Arg 
625                 630                 635                 640 


Ala Phe Lys Gln Gln Phe Val Asn Tyr Ala Thr Glu Lys Leu Arg Met 
                645                 650                 655     


Ile Val Ser Ser Thr Ser Ala Asn Cys Ser His Gln Val Lys Gln Gln 
            660                 665                 670         


Ile Ala Thr Thr Phe Ala Arg Leu Cys Gln Gln Val Asp Ile Thr Gln 
        675                 680                 685             


Lys Gln Leu Glu Glu Glu Ile Ala Arg Leu Pro Lys Glu Ile Asp Gln 
    690                 695                 700                 


Leu Glu Lys Ile Gln Asn Asn Ser Lys Leu Leu Arg Asn Lys Ala Val 
705                 710                 715                 720 


Gln Leu Glu Asn Glu Leu Glu Asn Phe Thr Lys Gln Phe Leu Pro Ser 
                725                 730                 735     


Ser Asn Glu Glu Ser 
            740     


<210>  611
<211>  6633
<212>  DNA
<213>  Homo sapiens

<400>  611
atgactgcgg cagcgaactg ggtggcgaac ggggcgagcc tggaggattg tcactccaac       60

ctcttttcgc tggctgaact cacgggaatc aaatggcgta ggtacaattt tggagggcat      120

ggggactgtg gacccataat ttcagcccca gcccaagatg atccaattct gttaagtttc      180

atccgctgtc tgcaagctaa cctgctttgt gtatggcgtc gtgatgtcaa accagattgc      240

aaagagttat ggatattctg gtggggagat gaacccaacc tagtgggtgt aatacatcat      300

gaactgcagg ttgtggaaga aggactctgg gaaaatggcc tttcctatga atgtaggacg      360

ctgctcttca aagcgatcca caatctgtta gaaaggtgcc taatggataa gaacttcgtt      420

aggattggga aatggtttgt ccgaccctac gaaaaggatg aaaagccagt caacaaaagt      480

gagcatttgt cctgtgcttt cacattcttt ctgcatggag aaagtaatgt atgcacaagt      540

gtggagattg cccagcacca gccaatttat ttgatcaatg aggagcatat acacatggct      600

cagtcttcac ctgcaccatt tcaagtactg gtaagtcctt atggcttaaa tgggacgcta      660

acaggccaag catacaagat gtcagaccca gccactcgta agttgattga ggaatggcag      720

tatttctacc cgatggtgct aaaaaagaaa gaagaatcga aagaggaaga cgagttggga      780

tatgatgatg atttccctgt ggcagttgaa gtaattgttg gtggtgttcg gatggtttac      840

ccttcagcat ttgttttgat ctctcagaat gacatcccgg ttcctcagag tgttgccagt      900

gctggaggcc acattgcagt tgggcagcaa gggcttggta gtgtgaagga cccaagtaac      960

tgtgggatgc ctctgacccc tcccacctct ccagaacagg ctatcctagg tgagagtgga     1020

ggtatgcaga gtgctgccag tcacctggtt tcccaagatg gagggatgat aacgatgcac     1080

agtccaaaga gatcggggaa gattcctcca aaactccaca atcatatggt ccatcgagtc     1140

tggaaggaat gcatcctcaa cagaacccag tccaagagga gccaaatgtc aactccaact     1200

cttgaagaag agcctgctag caatcctgct acttgggatt ttgtggatcc aacccaaaga     1260

gtcagctgtt cttgttccag gcataagctt ttaaaacgtt gtgcagtcgg gcccaatcga     1320

cctcccacag tatctcaacc agggttcagt gcaggaccat catcatcttc atctttacca     1380

cctcctgctt cttctaagca caaaacagca gaaagacagg aaaaaggaga caagctgcaa     1440

aagagaccct taataccatt tcaccatagg ccctctgtgg ccgaagaatt atgcatggag     1500

caagatacac caggacagaa actagggttg gcagggatag actcctcctt agaggtgtct     1560

agcagtagga aatatgataa gcaaatggcc gtgccttcca gaaatacaag caagcaaatg     1620

aatctgaatc ctatggattc acctcattcc cctatatccc ctctgccacc aacactcagc     1680

cctcagccac gaggtcagga aacagagagt ttggacccac catcggtccc tgtgaatcca     1740

gccctttatg gaaatggact agaactccag cagttgtcta ctctggatga cagaactgtc     1800

ctcgtaggcc aaagactgcc tctcatggca gaggtcagcg agacagcctt atattgtggg     1860

attaggccct cgaacccgga gtcatcagaa aagtggtggc atagttatcg tctcccaccc     1920

agtgatgatg ctgagttcag gcctccagag ctccagggtg agagatgtga tgccaaaatg     1980

gaggtaaact cagagagcac tgcattgcaa agactcttag cacaacctaa caaacggttt     2040

aaaatctggc aagacaaaca gccccagttg cagccactcc acttccttga cccattgcct     2100

ctatcacaac aacctggaga cagtttggga gaagtgaatg acccatatac ctttgaagat     2160

ggtgacataa aatacatctt tacagccaac aagaaatgca aacaagggac ggagaaagat     2220

tccctgaaaa agaataagtc agaggatgga tttggtacca aggatgtcac tacaccaggt     2280

cattccacgc cggtgcctga tgggaaaaat gccatgtcta ttttcagttc tgctactaaa     2340

acagatgtcc ggcaggataa tgctgctggc agagctggct ccagtagcct tacacaggta     2400

acagatttgg caccttccct gcatgactta gacaacatct ttgataattc tgatgacgac     2460

gaacttgggg ctgtatcacc tgctctgcgc tcatcaaaaa tgcctgcagt tgggacagaa     2520

gaccgacctc ttgggaagga tggaagagct gctgttcctt atccaccaac agttgcagac     2580

ttgcaaagga tgtttcccac tccaccatct ttggaacagc atcctgcatt ttctcctgtg     2640

atgaattata aagatgggat cagctcagag acagtgacag cattaggcat gatggagagc     2700

cctatggtca gtatggtttc aacacaactc acagaattca aaatggaagt ggaagatgga     2760

ttaggaagtc ccaagcccga ggaaattaag gacttttcat atgtgcacaa agttccatcc     2820

tttcaacctt ttgtgggatc ctccatgttt gctccactga agatgttgcc gagccattgt     2880

ttgctacctc tgaagatacc tgatgcctgt ctgtttcggc cttcatgggc aattcctcct     2940

aaaattgaac aactgcccat gccccctgca gccactttca ttagagatgg ctacaataac     3000

gtgcctagtg ttgggagcct agcagatcca gactatctga acacaccaca gatgaacaca     3060

cccgtgacgt tgaacagcgc tgccccagcc agcaatagtg gggcaggagt cctaccatct     3120

ccagcaaccc ctcgcttctc tgtccccaca ccacgaaccc ccaggacccc aagaactccc     3180

agaggtgggg gcactgccag tggtcaaggg tctgttaagt atgatagcac cgatcaagga     3240

tcaccagcct ccaccccctc tactacacgg cccctcaact ctgtggagcc cgccaccatg     3300

cagccaattc ccgaagccca cagcctctat gttaccctga ttctctccga ttccgtgatg     3360

aatatcttta aagacagaaa ctttgacagc tgttgcatct gtgcctgcaa catgaacatc     3420

aaaggggcgg atgtcgggct ttacatcccc gattcttcca atgaggacca gtaccgctgt     3480

acctgtgggt ttagtgcgat tatgaaccgc aaacttggct acaattcagg actcttcctt     3540

gaagatgagt tggatatttt tgggaagaat tctgatattg gtcaggctgc agagaggcgc     3600

ttaatgatgt gtcagtccac cttccttcct caggtggaag gaaccaaaaa accccaggag     3660

ccacccataa gccttctcct cctcctccag aatcaacaca cacaaccttt tgcttcactg     3720

aatttcctgg actacatttc ctctaacaat cgccaaactc ttccctgtgt aagctggagt     3780

tatgaccggg tgcaagcaga taataatgat tactggacgg aatgctttaa tgcgttggag     3840

caggggcggc agtatgtgga taaccccact ggtggaaaag tggacgaagc tctggtgaga     3900

agtgccactg tgcactcttg gcctcacagc aatgtgctgg acatcagcat gctctcctcc     3960

caggatgtgg ttcgtatgct gttgtccctg cagccctttc tccaagatgc catccaaaag     4020

aagcgcacgg gcaggacctg ggagaacatc cagcatgtgc agggaccact cacttggcag     4080

cagttccata aaatggcagg acggggaacc tacggttcgg aagaatctcc tgagccgttg     4140

cccatcccca ctctgctggt aggctatgac aaggatttcc tcaccatctc gccattctcc     4200

ttgccgtttt gggagaggct cttgttggac ccatatgggg gccaccgtga tgttgcctat     4260

attgtggtgt gtccagaaaa tgaggccttg ctcgaaggag ccaaaacttt cttcagggac     4320

ttgagtgctg tatacgagat gtgtaggctt gggcagcaca agcccatctg caaagtgcta     4380

cgtgacggga tcatgcgcgt gggaaaaact gtggcacaga agctgacaga tgagcttgtg     4440

agtgagtggt ttaaccagcc ttggagcggc gaggagaatg acaatcattc cagactcaaa     4500

ctttatgcgc aagtttgccg ccatcaccta gcaccttatt tagccactct gcagcttgat     4560

agcagcctat tgataccacc taaataccag accccaccag cagcagcaca gggacaagct     4620

acgccaggga atgctgggcc cttagctcca aatggatcag cagctccccc agctggcagt     4680

gcatttaatc ccacctcgaa tagtagttct acaaatcctg cagcaagtag ttctgcatct     4740

ggttcctctg tgccaccggt ctcatcgtct gcctctgctc ctggtattag ccagataagc     4800

actacctctt cttcaggatt cagtggtagt gttggagggc agaaccccag cactgggggc     4860

atttctgcgg atagaacgca agggaacata ggctgtggtg gagacactga ccctgggcag     4920

agctcttctc agccctcaca ggatggacaa gagagtgtta cagaaaggga gagaatagga     4980

attcccacgg agcctgactc tgcagacagc catgcccacc ctccagctgt tgtcatttac     5040

atggtggacc cgttcacgta tgctgcagag gaggactcca cttctgggaa cttttggctg     5100

ttgagcttga tgcgctgcta cacagaaatg ctggataatt tacctgagca tatgagaaat     5160

tctttcattc tccagattgt gccttgccag tacatgctgc agacaatgaa ggatgagcaa     5220

gttttctaca ttcaatactt gaagtccatg gcattttcag tgtactgcca gtgcaggcga     5280

ccactgccta cacagatcca cattaaatcc ctcacgggat ttgggcctgc agccagcatt     5340

gagatgaccc tcaagaaccc tgagcggccc agcccaatcc agctttactc ccctcccttt     5400

atattggccc caatcaaaga caagcagaca gagctgggag agacgtttgg tgaggcgagc     5460

cagaaataca atgtgctctt cgtgggctat tgtctgtctc acgaccagcg ctggcttttg     5520

gcttcctgca ctgacctcca tggggaatta ttagagacct gcgttgtaaa tattgcttta     5580

ccaaacaggt cacggaggag taaagtatct gcacgtaaaa ttggactaca gaagttatgg     5640

gagtggtgca tagggattgt ccaaatgaca tctctaccct ggagagttgt aatcgggcga     5700

cttgggcgtc ttggccatgg ggagcttaaa gattggagta tcctccttgg agaatgttca     5760

ctacagacaa tcagcaaaaa gctcaaggat gtgtgccgga tgtgtggaat ctctgccgca     5820

gactctcctt ctatccttag tgcctgcctg gttgccatgg agccccaggg gtcctttgta     5880

gtgatgccag atgctgtcac aatgggctct gtttttggcc gaagtactgc actgaacatg     5940

cagtcatctc agctcaacac ccctcaagat gcttcttgta cacacatctt ggtgttccca     6000

acatcatcaa ccatccaggt ggctccagcc aactacccca atgaagatgg gtttagcccc     6060

aacaatgatg atatgtttgt tgaccttcca ttcccagatg atatggacaa tgatattggc     6120

atattaatga ctgggaacct ccattcctct cccaactctt ccccagtacc ctccccaggc     6180

tctccttctg gaattggtgt gggctctcac ttccagcata gtcggagcca gggtgagcgt     6240

cttctttcta gagaagcacc agaggagcta aagcagcagc ccctggccct tgggtatttt     6300

gtatcaactg ccaaagctga gaatcttccc cagtggtttt ggtcatcgtg tccccaggct     6360

caaaaccagt gccctctctt cttaaaggct tcgctgcatc accacatttc agtagcacag     6420

acagacgaac ttctgcctgc caggaattct cagcgggttc cacaccctct tgactccaaa     6480

accacgtcgg atgttttaag gtttgttttg gagcagtaca acgctctgtc ctggctcacg     6540

tgcaatccgg ccacccagga ccgtacttcc tgccttcccg tccactttgt ggtgctcact     6600

cagttgtaca atgccatcat gaatatactt taa                                  6633


<210>  612
<211>  2210
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Thr Ala Ala Ala Asn Trp Val Ala Asn Gly Ala Ser Leu Glu Asp 
1               5                   10                  15      


Cys His Ser Asn Leu Phe Ser Leu Ala Glu Leu Thr Gly Ile Lys Trp 
            20                  25                  30          


Arg Arg Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser 
        35                  40                  45              


Ala Pro Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu 
    50                  55                  60                  


Gln Ala Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys 
65                  70                  75                  80  


Lys Glu Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly 
                85                  90                  95      


Val Ile His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn 
            100                 105                 110         


Gly Leu Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn 
        115                 120                 125             


Leu Leu Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys 
    130                 135                 140                 


Trp Phe Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser 
145                 150                 155                 160 


Glu His Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn 
                165                 170                 175     


Val Cys Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile 
            180                 185                 190         


Asn Glu Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln 
        195                 200                 205             


Val Leu Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala 
    210                 215                 220                 


Tyr Lys Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln 
225                 230                 235                 240 


Tyr Phe Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu 
                245                 250                 255     


Asp Glu Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile 
            260                 265                 270         


Val Gly Gly Val Arg Met Val Tyr Pro Ser Ala Phe Val Leu Ile Ser 
        275                 280                 285             


Gln Asn Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His 
    290                 295                 300                 


Ile Ala Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn 
305                 310                 315                 320 


Cys Gly Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu 
                325                 330                 335     


Gly Glu Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln 
            340                 345                 350         


Asp Gly Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile 
        355                 360                 365             


Pro Pro Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys 
    370                 375                 380                 


Ile Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr 
385                 390                 395                 400 


Leu Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp 
                405                 410                 415     


Pro Thr Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys 
            420                 425                 430         


Arg Cys Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly 
        435                 440                 445             


Phe Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser 
    450                 455                 460                 


Ser Lys His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln 
465                 470                 475                 480 


Lys Arg Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu 
                485                 490                 495     


Leu Cys Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly 
            500                 505                 510         


Ile Asp Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln 
        515                 520                 525             


Met Ala Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro 
    530                 535                 540                 


Met Asp Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val 
                565                 570                 575     


Pro Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu 
            580                 585                 590         


Ser Thr Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu 
        595                 600                 605             


Met Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser 
    610                 615                 620                 


Asn Pro Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro 
625                 630                 635                 640 


Ser Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys 
                645                 650                 655     


Asp Ala Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu 
            660                 665                 670         


Leu Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro 
        675                 680                 685             


Gln Leu Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln 
    690                 695                 700                 


Pro Gly Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp 
705                 710                 715                 720 


Gly Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly 
                725                 730                 735     


Thr Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly 
            740                 745                 750         


Thr Lys Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly 
        755                 760                 765             


Lys Asn Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg 
    770                 775                 780                 


Gln Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val 
785                 790                 795                 800 


Thr Asp Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn 
                805                 810                 815     


Ser Asp Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser 
            820                 825                 830         


Lys Met Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly 
        835                 840                 845             


Arg Ala Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met 
    850                 855                 860                 


Phe Pro Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val 
865                 870                 875                 880 


Met Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly 
                885                 890                 895     


Met Met Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu 
            900                 905                 910         


Phe Lys Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu 
        915                 920                 925             


Ile Lys Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe 
    930                 935                 940                 


Val Gly Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys 
945                 950                 955                 960 


Leu Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp 
                965                 970                 975     


Ala Ile Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr 
            980                 985                 990         


Phe Ile Arg Asp Gly Tyr Asn Asn  Val Pro Ser Val Gly  Ser Leu Ala 
        995                 1000                 1005             


Asp Pro  Asp Tyr Leu Asn Thr  Pro Gln Met Asn Thr  Pro Val Thr 
    1010                 1015                 1020             


Leu Asn  Ser Ala Ala Pro Ala  Ser Asn Ser Gly Ala  Gly Val Leu 
    1025                 1030                 1035             


Pro Ser  Pro Ala Thr Pro Arg  Phe Ser Val Pro Thr  Pro Arg Thr 
    1040                 1045                 1050             


Pro Arg  Thr Pro Arg Thr Pro  Arg Gly Gly Gly Thr  Ala Ser Gly 
    1055                 1060                 1065             


Gln Gly  Ser Val Lys Tyr Asp  Ser Thr Asp Gln Gly  Ser Pro Ala 
    1070                 1075                 1080             


Ser Thr  Pro Ser Thr Thr Arg  Pro Leu Asn Ser Val  Glu Pro Ala 
    1085                 1090                 1095             


Thr Met  Gln Pro Ile Pro Glu  Ala His Ser Leu Tyr  Val Thr Leu 
    1100                 1105                 1110             


Ile Leu  Ser Asp Ser Val Met  Asn Ile Phe Lys Asp  Arg Asn Phe 
    1115                 1120                 1125             


Asp Ser  Cys Cys Ile Cys Ala  Cys Asn Met Asn Ile  Lys Gly Ala 
    1130                 1135                 1140             


Asp Val  Gly Leu Tyr Ile Pro  Asp Ser Ser Asn Glu  Asp Gln Tyr 
    1145                 1150                 1155             


Arg Cys  Thr Cys Gly Phe Ser  Ala Ile Met Asn Arg  Lys Leu Gly 
    1160                 1165                 1170             


Tyr Asn  Ser Gly Leu Phe Leu  Glu Asp Glu Leu Asp  Ile Phe Gly 
    1175                 1180                 1185             


Lys Asn  Ser Asp Ile Gly Gln  Ala Ala Glu Arg Arg  Leu Met Met 
    1190                 1195                 1200             


Cys Gln  Ser Thr Phe Leu Pro  Gln Val Glu Gly Thr  Lys Lys Pro 
    1205                 1210                 1215             


Gln Glu  Pro Pro Ile Ser Leu  Leu Leu Leu Leu Gln  Asn Gln His 
    1220                 1225                 1230             


Thr Gln  Pro Phe Ala Ser Leu  Asn Phe Leu Asp Tyr  Ile Ser Ser 
    1235                 1240                 1245             


Asn Asn  Arg Gln Thr Leu Pro  Cys Val Ser Trp Ser  Tyr Asp Arg 
    1250                 1255                 1260             


Val Gln  Ala Asp Asn Asn Asp  Tyr Trp Thr Glu Cys  Phe Asn Ala 
    1265                 1270                 1275             


Leu Glu  Gln Gly Arg Gln Tyr  Val Asp Asn Pro Thr  Gly Gly Lys 
    1280                 1285                 1290             


Val Asp  Glu Ala Leu Val Arg  Ser Ala Thr Val His  Ser Trp Pro 
    1295                 1300                 1305             


His Ser  Asn Val Leu Asp Ile  Ser Met Leu Ser Ser  Gln Asp Val 
    1310                 1315                 1320             


Val Arg  Met Leu Leu Ser Leu  Gln Pro Phe Leu Gln  Asp Ala Ile 
    1325                 1330                 1335             


Gln Lys  Lys Arg Thr Gly Arg  Thr Trp Glu Asn Ile  Gln His Val 
    1340                 1345                 1350             


Gln Gly  Pro Leu Thr Trp Gln  Gln Phe His Lys Met  Ala Gly Arg 
    1355                 1360                 1365             


Gly Thr  Tyr Gly Ser Glu Glu  Ser Pro Glu Pro Leu  Pro Ile Pro 
    1370                 1375                 1380             


Thr Leu  Leu Val Gly Tyr Asp  Lys Asp Phe Leu Thr  Ile Ser Pro 
    1385                 1390                 1395             


Phe Ser  Leu Pro Phe Trp Glu  Arg Leu Leu Leu Asp  Pro Tyr Gly 
    1400                 1405                 1410             


Gly His  Arg Asp Val Ala Tyr  Ile Val Val Cys Pro  Glu Asn Glu 
    1415                 1420                 1425             


Ala Leu  Leu Glu Gly Ala Lys  Thr Phe Phe Arg Asp  Leu Ser Ala 
    1430                 1435                 1440             


Val Tyr  Glu Met Cys Arg Leu  Gly Gln His Lys Pro  Ile Cys Lys 
    1445                 1450                 1455             


Val Leu  Arg Asp Gly Ile Met  Arg Val Gly Lys Thr  Val Ala Gln 
    1460                 1465                 1470             


Lys Leu  Thr Asp Glu Leu Val  Ser Glu Trp Phe Asn  Gln Pro Trp 
    1475                 1480                 1485             


Ser Gly  Glu Glu Asn Asp Asn  His Ser Arg Leu Lys  Leu Tyr Ala 
    1490                 1495                 1500             


Gln Val  Cys Arg His His Leu  Ala Pro Tyr Leu Ala  Thr Leu Gln 
    1505                 1510                 1515             


Leu Asp  Ser Ser Leu Leu Ile  Pro Pro Lys Tyr Gln  Thr Pro Pro 
    1520                 1525                 1530             


Ala Ala  Ala Gln Gly Gln Ala  Thr Pro Gly Asn Ala  Gly Pro Leu 
    1535                 1540                 1545             


Ala Pro  Asn Gly Ser Ala Ala  Pro Pro Ala Gly Ser  Ala Phe Asn 
    1550                 1555                 1560             


Pro Thr  Ser Asn Ser Ser Ser  Thr Asn Pro Ala Ala  Ser Ser Ser 
    1565                 1570                 1575             


Ala Ser  Gly Ser Ser Val Pro  Pro Val Ser Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Pro Gly  Ile Ser Gln Ile Ser  Thr Thr Ser Ser Ser  Gly Phe Ser 
    1595                 1600                 1605             


Gly Ser  Val Gly Gly Gln Asn  Pro Ser Thr Gly Gly  Ile Ser Ala 
    1610                 1615                 1620             


Asp Arg  Thr Gln Gly Asn Ile  Gly Cys Gly Gly Asp  Thr Asp Pro 
    1625                 1630                 1635             


Gly Gln  Ser Ser Ser Gln Pro  Ser Gln Asp Gly Gln  Glu Ser Val 
    1640                 1645                 1650             


Thr Glu  Arg Glu Arg Ile Gly  Ile Pro Thr Glu Pro  Asp Ser Ala 
    1655                 1660                 1665             


Asp Ser  His Ala His Pro Pro  Ala Val Val Ile Tyr  Met Val Asp 
    1670                 1675                 1680             


Pro Phe  Thr Tyr Ala Ala Glu  Glu Asp Ser Thr Ser  Gly Asn Phe 
    1685                 1690                 1695             


Trp Leu  Leu Ser Leu Met Arg  Cys Tyr Thr Glu Met  Leu Asp Asn 
    1700                 1705                 1710             


Leu Pro  Glu His Met Arg Asn  Ser Phe Ile Leu Gln  Ile Val Pro 
    1715                 1720                 1725             


Cys Gln  Tyr Met Leu Gln Thr  Met Lys Asp Glu Gln  Val Phe Tyr 
    1730                 1735                 1740             


Ile Gln  Tyr Leu Lys Ser Met  Ala Phe Ser Val Tyr  Cys Gln Cys 
    1745                 1750                 1755             


Arg Arg  Pro Leu Pro Thr Gln  Ile His Ile Lys Ser  Leu Thr Gly 
    1760                 1765                 1770             


Phe Gly  Pro Ala Ala Ser Ile  Glu Met Thr Leu Lys  Asn Pro Glu 
    1775                 1780                 1785             


Arg Pro  Ser Pro Ile Gln Leu  Tyr Ser Pro Pro Phe  Ile Leu Ala 
    1790                 1795                 1800             


Pro Ile  Lys Asp Lys Gln Thr  Glu Leu Gly Glu Thr  Phe Gly Glu 
    1805                 1810                 1815             


Ala Ser  Gln Lys Tyr Asn Val  Leu Phe Val Gly Tyr  Cys Leu Ser 
    1820                 1825                 1830             


His Asp  Gln Arg Trp Leu Leu  Ala Ser Cys Thr Asp  Leu His Gly 
    1835                 1840                 1845             


Glu Leu  Leu Glu Thr Cys Val  Val Asn Ile Ala Leu  Pro Asn Arg 
    1850                 1855                 1860             


Ser Arg  Arg Ser Lys Val Ser  Ala Arg Lys Ile Gly  Leu Gln Lys 
    1865                 1870                 1875             


Leu Trp  Glu Trp Cys Ile Gly  Ile Val Gln Met Thr  Ser Leu Pro 
    1880                 1885                 1890             


Trp Arg  Val Val Ile Gly Arg  Leu Gly Arg Leu Gly  His Gly Glu 
    1895                 1900                 1905             


Leu Lys  Asp Trp Ser Ile Leu  Leu Gly Glu Cys Ser  Leu Gln Thr 
    1910                 1915                 1920             


Ile Ser  Lys Lys Leu Lys Asp  Val Cys Arg Met Cys  Gly Ile Ser 
    1925                 1930                 1935             


Ala Ala  Asp Ser Pro Ser Ile  Leu Ser Ala Cys Leu  Val Ala Met 
    1940                 1945                 1950             


Glu Pro  Gln Gly Ser Phe Val  Val Met Pro Asp Ala  Val Thr Met 
    1955                 1960                 1965             


Gly Ser  Val Phe Gly Arg Ser  Thr Ala Leu Asn Met  Gln Ser Ser 
    1970                 1975                 1980             


Gln Leu  Asn Thr Pro Gln Asp  Ala Ser Cys Thr His  Ile Leu Val 
    1985                 1990                 1995             


Phe Pro  Thr Ser Ser Thr Ile  Gln Val Ala Pro Ala  Asn Tyr Pro 
    2000                 2005                 2010             


Asn Glu  Asp Gly Phe Ser Pro  Asn Asn Asp Asp Met  Phe Val Asp 
    2015                 2020                 2025             


Leu Pro  Phe Pro Asp Asp Met  Asp Asn Asp Ile Gly  Ile Leu Met 
    2030                 2035                 2040             


Thr Gly  Asn Leu His Ser Ser  Pro Asn Ser Ser Pro  Val Pro Ser 
    2045                 2050                 2055             


Pro Gly  Ser Pro Ser Gly Ile  Gly Val Gly Ser His  Phe Gln His 
    2060                 2065                 2070             


Ser Arg  Ser Gln Gly Glu Arg  Leu Leu Ser Arg Glu  Ala Pro Glu 
    2075                 2080                 2085             


Glu Leu  Lys Gln Gln Pro Leu  Ala Leu Gly Tyr Phe  Val Ser Thr 
    2090                 2095                 2100             


Ala Lys  Ala Glu Asn Leu Pro  Gln Trp Phe Trp Ser  Ser Cys Pro 
    2105                 2110                 2115             


Gln Ala  Gln Asn Gln Cys Pro  Leu Phe Leu Lys Ala  Ser Leu His 
    2120                 2125                 2130             


His His  Ile Ser Val Ala Gln  Thr Asp Glu Leu Leu  Pro Ala Arg 
    2135                 2140                 2145             


Asn Ser  Gln Arg Val Pro His  Pro Leu Asp Ser Lys  Thr Thr Ser 
    2150                 2155                 2160             


Asp Val  Leu Arg Phe Val Leu  Glu Gln Tyr Asn Ala  Leu Ser Trp 
    2165                 2170                 2175             


Leu Thr  Cys Asn Pro Ala Thr  Gln Asp Arg Thr Ser  Cys Leu Pro 
    2180                 2185                 2190             


Val His  Phe Val Val Leu Thr  Gln Leu Tyr Asn Ala  Ile Met Asn 
    2195                 2200                 2205             


Ile Leu  
    2210 


<210>  613
<211>  3234
<212>  DNA
<213>  Homo sapiens

<400>  613
atggacacag actctcagcg ttctcatctc tcttccttca ccatgaagct gatggacaaa       60

ttccactcac ccaaaatcaa gagaacgcca tcaaagaagg gaaaaccagc tgaggtgtcc      120

gtaaagattc cagagaagcc tgtgaacaaa gaggcaacag acagatttct accagagggc      180

taccctctcc ccttggatct ggagcagcag gcagtagaat ttatgtccac cagtgctgtg      240

gcttccaggt ctcaaaggca gaagaacctg agctggctgg aggagaaaga gaaggaagtt      300

gtcagtgccc tgcgctactt taagaccatt gtggacaaaa tggcaattga taagaaggta      360

ctggagatgc ttccagggtc agccagcaag gtgctggagg ccatcttacc cctggtgcag      420

aacgatcctc gaattcagca cagctcagcc ctctcttcct gctatagccg agtgtaccaa      480

agcctcgcca acctcattcg ctggtctgac caagtgatgc tggaaggcgt gaactcagaa      540

gacaaggaga tggtgacgac tgtgaagggg gtcatcaagg ctgtgctgga tggagtgaag      600

gagctggtca ggctcaccat cgagaagcag ggacgtccgt ctccgacgag ccccgtgaag      660

cccagttccc ctgccagcaa gcctgatggc ccagcagagc tccccctgac agaccgcgag      720

gtagagatcc taaacaagac gactgggatg tcacagtcaa ctgagctcct cccagatgcc      780

acggatgaag aggtcgcgcc ccccaagcct cctctgcctg gcattcgggt ggttgataat      840

agtcctccac cagcattgcc acccaagaaa agacagtcgg cgccgtcccc tacccgagtg      900

gctgtggtgg cccccatgag ccgagccacc agtggctcca gtttgcctgt tggaatcaat      960

aggcaggatt ttgatgttga ctgttacgca cagaggcgac tgtcaggagg cagccactca     1020

tatggtggag agtcgccccg cctctccccc tgcagcagca taggcaagct cagcaagtca     1080

gacgagcagc tgtcctctct ggacagggac agtgggcagt gctcccggaa cacaagctgt     1140

gaaacactag accactatga tcccgactat gaattcctcc agcaagacct ctctaacgca     1200

gaccagatac ctcagcagac ggcctggaac cttagcccgt tgccagagtc tttgggggag     1260

tctgggtctc catttcttgg ccctcctttc cagctgcctc ttggcggcca tccccagcca     1320

gacggacctc tggccccagg gcagcagaca gatacgccac ctgctctccc cgagaagaag     1380

cgcaggagcg cagcctccca gacggcggac ggctctggct gcagggtgtc ctacgagcgg     1440

catccctcgc agtatgacaa catctctggg gaggacctgc agagcacagc cccgatccca     1500

tccgtcccct acgcgccctt tgctgctatt ctgccctttc agcatggagg ttcctcagcc     1560

cctgtcgaat ttgtgggtga ttttactgct cctgagtcaa ccggtgaccc agaaaaacca     1620

cctcctctac cagagaagaa aaacaaacac atgctggcct acatgcagtt gctggaggac     1680

tactcggagc cgcagccctc tatgttctac cagacgccac agaacgagca catctaccag     1740

cagaagaaca agctcctcat ggaggtatac ggcttcagcg actccttcag tggggtggac     1800

tccgtgcagg agctggcccc gccgcccgcc ctacccccca agcagcggca gctggagcca     1860

ccggctggga aagacggaca tcccagagat ccctcagcgg tcagcggcgt ccctgggaag     1920

gacagcagag acggcagtga gagggcccca aagtcaccag atgctctgga gtcggctcag     1980

tcggaggagg aagtggacga gctgtccctc attgaccaca acgaaattat gtccaggctg     2040

acgctcaagc aggagggtga tgacgggccg gacgtccgcg gaggatctgg ggacatctta     2100

ctggtccatg ctactgagac tgacaggaaa gatttggtgt tgtactgcga ggcattcctg     2160

accacctaca ggaccttcat ctccccagag gagctcatca agaagctgca gtacagatat     2220

gagaaattct ctccctttgc cgacacattc aagaagcgcg tcagcaagaa cacgttcttc     2280

gtgctggtac gggtggtgga tgagctctgc ctggtggagt tgacagaaga gatcctgaag     2340

ctgctgatgg aactggtctt ccgcctggtg tgcaatgggg agctgagcct ggcccgtgtg     2400

ctccggaaga acatcctgga caaggtggac cagaagaagc tactcaggtg tgccacctcc     2460

agccagcccc tggcagcccg gggggtagca gccaggccgg ggaccttgca cgactttcac     2520

agccatgaga tagcggagca gctaacgctg ctggatgctg agctcttcta taaaatagag     2580

attcctgagg ttttgctttg ggcaaaagag cagaatgagg agaagagccc caacttgacc     2640

cagttcacgg agcacttcaa caacatgtcc tactgggtcc ggtccataat catgttacag     2700

gaaaaggccc aggacaggga acggctgctc ttgaagttca tcaagatcat gaagcacttg     2760

cggaagctga ataacttcaa ctcctacttg gccatcctct ctgccctgga ctcggcgccc     2820

atccgcaggc tggagtggca gaagcagact tcagagggcc tggccgagta ctgcacactg     2880

atcgacagct cgtcctcctt ccgagcctac cgggccgccc tctcggaggt ggaaccgccg     2940

tgcatcccgt acctggggct gatcctgcag gacctgacct tcgttcacct gggaaaccca     3000

gactacatcg acgggaaagt gaacttctcc aagcggtggc agcagttcaa catcctcgac     3060

agcatgcgct gcttccagca ggcgcactat gacatgcgga ggaacgacga cattataaac     3120

ttcttcaatg acttcagtga ccacctggct gaggaggccc tatgggaact gtctctgaaa     3180

attaaaccca ggaacataac aaggagaaaa acagaccggg aagagaagac ctag           3234


<210>  614
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Asp Thr Asp Ser Gln Arg Ser His Leu Ser Ser Phe Thr Met Lys 
1               5                   10                  15      


Leu Met Asp Lys Phe His Ser Pro Lys Ile Lys Arg Thr Pro Ser Lys 
            20                  25                  30          


Lys Gly Lys Pro Ala Glu Val Ser Val Lys Ile Pro Glu Lys Pro Val 
        35                  40                  45              


Asn Lys Glu Ala Thr Asp Arg Phe Leu Pro Glu Gly Tyr Pro Leu Pro 
    50                  55                  60                  


Leu Asp Leu Glu Gln Gln Ala Val Glu Phe Met Ser Thr Ser Ala Val 
65                  70                  75                  80  


Ala Ser Arg Ser Gln Arg Gln Lys Asn Leu Ser Trp Leu Glu Glu Lys 
                85                  90                  95      


Glu Lys Glu Val Val Ser Ala Leu Arg Tyr Phe Lys Thr Ile Val Asp 
            100                 105                 110         


Lys Met Ala Ile Asp Lys Lys Val Leu Glu Met Leu Pro Gly Ser Ala 
        115                 120                 125             


Ser Lys Val Leu Glu Ala Ile Leu Pro Leu Val Gln Asn Asp Pro Arg 
    130                 135                 140                 


Ile Gln His Ser Ser Ala Leu Ser Ser Cys Tyr Ser Arg Val Tyr Gln 
145                 150                 155                 160 


Ser Leu Ala Asn Leu Ile Arg Trp Ser Asp Gln Val Met Leu Glu Gly 
                165                 170                 175     


Val Asn Ser Glu Asp Lys Glu Met Val Thr Thr Val Lys Gly Val Ile 
            180                 185                 190         


Lys Ala Val Leu Asp Gly Val Lys Glu Leu Val Arg Leu Thr Ile Glu 
        195                 200                 205             


Lys Gln Gly Arg Pro Ser Pro Thr Ser Pro Val Lys Pro Ser Ser Pro 
    210                 215                 220                 


Ala Ser Lys Pro Asp Gly Pro Ala Glu Leu Pro Leu Thr Asp Arg Glu 
225                 230                 235                 240 


Val Glu Ile Leu Asn Lys Thr Thr Gly Met Ser Gln Ser Thr Glu Leu 
                245                 250                 255     


Leu Pro Asp Ala Thr Asp Glu Glu Val Ala Pro Pro Lys Pro Pro Leu 
            260                 265                 270         


Pro Gly Ile Arg Val Val Asp Asn Ser Pro Pro Pro Ala Leu Pro Pro 
        275                 280                 285             


Lys Lys Arg Gln Ser Ala Pro Ser Pro Thr Arg Val Ala Val Val Ala 
    290                 295                 300                 


Pro Met Ser Arg Ala Thr Ser Gly Ser Ser Leu Pro Val Gly Ile Asn 
305                 310                 315                 320 


Arg Gln Asp Phe Asp Val Asp Cys Tyr Ala Gln Arg Arg Leu Ser Gly 
                325                 330                 335     


Gly Ser His Ser Tyr Gly Gly Glu Ser Pro Arg Leu Ser Pro Cys Ser 
            340                 345                 350         


Ser Ile Gly Lys Leu Ser Lys Ser Asp Glu Gln Leu Ser Ser Leu Asp 
        355                 360                 365             


Arg Asp Ser Gly Gln Cys Ser Arg Asn Thr Ser Cys Glu Thr Leu Asp 
    370                 375                 380                 


His Tyr Asp Pro Asp Tyr Glu Phe Leu Gln Gln Asp Leu Ser Asn Ala 
385                 390                 395                 400 


Asp Gln Ile Pro Gln Gln Thr Ala Trp Asn Leu Ser Pro Leu Pro Glu 
                405                 410                 415     


Ser Leu Gly Glu Ser Gly Ser Pro Phe Leu Gly Pro Pro Phe Gln Leu 
            420                 425                 430         


Pro Leu Gly Gly His Pro Gln Pro Asp Gly Pro Leu Ala Pro Gly Gln 
        435                 440                 445             


Gln Thr Asp Thr Pro Pro Ala Leu Pro Glu Lys Lys Arg Arg Ser Ala 
    450                 455                 460                 


Ala Ser Gln Thr Ala Asp Gly Ser Gly Cys Arg Val Ser Tyr Glu Arg 
465                 470                 475                 480 


His Pro Ser Gln Tyr Asp Asn Ile Ser Gly Glu Asp Leu Gln Ser Thr 
                485                 490                 495     


Ala Pro Ile Pro Ser Val Pro Tyr Ala Pro Phe Ala Ala Ile Leu Pro 
            500                 505                 510         


Phe Gln His Gly Gly Ser Ser Ala Pro Val Glu Phe Val Gly Asp Phe 
        515                 520                 525             


Thr Ala Pro Glu Ser Thr Gly Asp Pro Glu Lys Pro Pro Pro Leu Pro 
    530                 535                 540                 


Glu Lys Lys Asn Lys His Met Leu Ala Tyr Met Gln Leu Leu Glu Asp 
545                 550                 555                 560 


Tyr Ser Glu Pro Gln Pro Ser Met Phe Tyr Gln Thr Pro Gln Asn Glu 
                565                 570                 575     


His Ile Tyr Gln Gln Lys Asn Lys Leu Leu Met Glu Val Tyr Gly Phe 
            580                 585                 590         


Ser Asp Ser Phe Ser Gly Val Asp Ser Val Gln Glu Leu Ala Pro Pro 
        595                 600                 605             


Pro Ala Leu Pro Pro Lys Gln Arg Gln Leu Glu Pro Pro Ala Gly Lys 
    610                 615                 620                 


Asp Gly His Pro Arg Asp Pro Ser Ala Val Ser Gly Val Pro Gly Lys 
625                 630                 635                 640 


Asp Ser Arg Asp Gly Ser Glu Arg Ala Pro Lys Ser Pro Asp Ala Leu 
                645                 650                 655     


Glu Ser Ala Gln Ser Glu Glu Glu Val Asp Glu Leu Ser Leu Ile Asp 
            660                 665                 670         


His Asn Glu Ile Met Ser Arg Leu Thr Leu Lys Gln Glu Gly Asp Asp 
        675                 680                 685             


Gly Pro Asp Val Arg Gly Gly Ser Gly Asp Ile Leu Leu Val His Ala 
    690                 695                 700                 


Thr Glu Thr Asp Arg Lys Asp Leu Val Leu Tyr Cys Glu Ala Phe Leu 
705                 710                 715                 720 


Thr Thr Tyr Arg Thr Phe Ile Ser Pro Glu Glu Leu Ile Lys Lys Leu 
                725                 730                 735     


Gln Tyr Arg Tyr Glu Lys Phe Ser Pro Phe Ala Asp Thr Phe Lys Lys 
            740                 745                 750         


Arg Val Ser Lys Asn Thr Phe Phe Val Leu Val Arg Val Val Asp Glu 
        755                 760                 765             


Leu Cys Leu Val Glu Leu Thr Glu Glu Ile Leu Lys Leu Leu Met Glu 
    770                 775                 780                 


Leu Val Phe Arg Leu Val Cys Asn Gly Glu Leu Ser Leu Ala Arg Val 
785                 790                 795                 800 


Leu Arg Lys Asn Ile Leu Asp Lys Val Asp Gln Lys Lys Leu Leu Arg 
                805                 810                 815     


Cys Ala Thr Ser Ser Gln Pro Leu Ala Ala Arg Gly Val Ala Ala Arg 
            820                 825                 830         


Pro Gly Thr Leu His Asp Phe His Ser His Glu Ile Ala Glu Gln Leu 
        835                 840                 845             


Thr Leu Leu Asp Ala Glu Leu Phe Tyr Lys Ile Glu Ile Pro Glu Val 
    850                 855                 860                 


Leu Leu Trp Ala Lys Glu Gln Asn Glu Glu Lys Ser Pro Asn Leu Thr 
865                 870                 875                 880 


Gln Phe Thr Glu His Phe Asn Asn Met Ser Tyr Trp Val Arg Ser Ile 
                885                 890                 895     


Ile Met Leu Gln Glu Lys Ala Gln Asp Arg Glu Arg Leu Leu Leu Lys 
            900                 905                 910         


Phe Ile Lys Ile Met Lys His Leu Arg Lys Leu Asn Asn Phe Asn Ser 
        915                 920                 925             


Tyr Leu Ala Ile Leu Ser Ala Leu Asp Ser Ala Pro Ile Arg Arg Leu 
    930                 935                 940                 


Glu Trp Gln Lys Gln Thr Ser Glu Gly Leu Ala Glu Tyr Cys Thr Leu 
945                 950                 955                 960 


Ile Asp Ser Ser Ser Ser Phe Arg Ala Tyr Arg Ala Ala Leu Ser Glu 
                965                 970                 975     


Val Glu Pro Pro Cys Ile Pro Tyr Leu Gly Leu Ile Leu Gln Asp Leu 
            980                 985                 990         


Thr Phe Val His Leu Gly Asn Pro  Asp Tyr Ile Asp Gly  Lys Val Asn 
        995                 1000                 1005             


Phe Ser  Lys Arg Trp Gln Gln  Phe Asn Ile Leu Asp  Ser Met Arg 
    1010                 1015                 1020             


Cys Phe  Gln Gln Ala His Tyr  Asp Met Arg Arg Asn  Asp Asp Ile 
    1025                 1030                 1035             


Ile Asn  Phe Phe Asn Asp Phe  Ser Asp His Leu Ala  Glu Glu Ala 
    1040                 1045                 1050             


Leu Trp  Glu Leu Ser Leu Lys  Ile Lys Pro Arg Asn  Ile Thr Arg 
    1055                 1060                 1065             


Arg Lys  Thr Asp Arg Glu Glu  Lys Thr 
    1070                 1075         


<210>  615
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  615
atgaaagtcc tgctttgtga cctgctgctg ctcagtctct tctccagtgt gttcagcagt       60

tgtcagaggg actgtctcac atgccaggag aagctccacc cagccctgga cagcttcgac      120

ctggaggtgt gcatcctcga gtgtgaagag aaggtcttcc ccagccccct ctggactcca      180

tgcaccaagg tcatggccag gagctcttgg cagctcagcc ctgccgcccc agagcatgtg      240

gcggctgctc tctaccagcc gagagcttcg gagatgcagc atctgcggcg aatgccccga      300

gtccggagct tgttccagga gcaggaagag cccgagcctg gcatggagga ggctggtgag      360

atggagcaga agcagctgca gaagagattt gggggcttca ccggggcccg gaagtcggcc      420

aggaagttgg ccaatcagaa gcggttcagt gagtttatga ggcaatactt ggtcctgagc      480

atgcagtcca gccagcgccg gcgcaccctg caccagaatg gtaatgtgta g               531


<210>  616
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  616

Met Lys Val Leu Leu Cys Asp Leu Leu Leu Leu Ser Leu Phe Ser Ser 
1               5                   10                  15      


Val Phe Ser Ser Cys Gln Arg Asp Cys Leu Thr Cys Gln Glu Lys Leu 
            20                  25                  30          


His Pro Ala Leu Asp Ser Phe Asp Leu Glu Val Cys Ile Leu Glu Cys 
        35                  40                  45              


Glu Glu Lys Val Phe Pro Ser Pro Leu Trp Thr Pro Cys Thr Lys Val 
    50                  55                  60                  


Met Ala Arg Ser Ser Trp Gln Leu Ser Pro Ala Ala Pro Glu His Val 
65                  70                  75                  80  


Ala Ala Ala Leu Tyr Gln Pro Arg Ala Ser Glu Met Gln His Leu Arg 
                85                  90                  95      


Arg Met Pro Arg Val Arg Ser Leu Phe Gln Glu Gln Glu Glu Pro Glu 
            100                 105                 110         


Pro Gly Met Glu Glu Ala Gly Glu Met Glu Gln Lys Gln Leu Gln Lys 
        115                 120                 125             


Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala 
    130                 135                 140                 


Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln Tyr Leu Val Leu Ser 
145                 150                 155                 160 


Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His Gln Asn Gly Asn Val 
                165                 170                 175     


<210>  617
<211>  1464
<212>  DNA
<213>  Homo sapiens

<400>  617
atggagacgg tacagctgag gaacccgccg cgccggcagc tgaaaaagtt ggatgaagat       60

agtttaacca aacaaccaga agaagtattt gatgtcttag agaaacttgg agaagggtcc      120

tatggcagcg tatacaaagc tattcataaa gagaccggcc agattgttgc tattaagcaa      180

gttcctgtgg aatcagacct ccaggagata atcaaagaaa tctctataat gcagcaatgt      240

gacagccctc atgtagtcaa atattatggc agttatttta agaacacaga cttatggatc      300

gttatggagt actgtggggc tggttctgta tctgatatca ttcgattacg aaataaaacg      360

ttaacagaag atgaaatagc tacaatatta caatcaactc ttaagggact tgaatacctt      420

cattttatga gaaaaataca ccgagatatc aaggcaggaa atattttgct aaatacagaa      480

ggacatgcaa aacttgcaga ttttggggta gcaggtcaac ttacagatac catggccaag      540

cggaatacag tgataggaac accattttgg atggctccag aagtgattca ggaaattgga      600

tacaactgtg tagcagacat ctggtccctg ggaataactg ccatagaaat ggctgaagga      660

aagccccctt atgctgatat ccatccaatg agggcaatct tcatgattcc tacaaatcct      720

cctcccacat tccgaaaacc agagctatgg tcagataact ttacagattt tgtgaaacag      780

tgtcttgtaa agagccctga gcagagggcc acagccactc agctcctgca gcacccattt      840

gtcaggagtg ccaaaggagt gtcaatactg cgagacttaa ttaatgaagc catggatgtg      900

aaactgaaac gccaggaatc ccagcagcgg gaagtggacc aggacgatga agaaaactca      960

gaagaggatg aaatggattc tggcacgatg gttcgagcag tgggtgatga gatgggcact     1020

gtccgagtag ccagcaccat gactgatgga gccaatacta tgattgagca cgatgacacg     1080

ttgccatcac aactgggcac catggtgatc aatgcagagg atgaggaaga ggaaggaact     1140

atgaaaagaa gggatgagac catgcagcct gcgaaaccat cctttcttga atattttgaa     1200

caaaaagaaa aggaaaacca gatcaacagc tttggcaaga gtgtacctgg tccactgaaa     1260

aattcttcag attggaaaat accacaggat ggagactacg agtttcttaa gagttggaca     1320

gtggaggacc ttcagaagag gctcttggcc ctggacccca tgatggagca ggagattgaa     1380

gagatccggc agaagtacca gtccaagcgg cagcccatcc tggatgccat agaggctaag     1440

aagagacggc aacaaaactt ctga                                            1464


<210>  618
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  618

Met Glu Thr Val Gln Leu Arg Asn Pro Pro Arg Arg Gln Leu Lys Lys 
1               5                   10                  15      


Leu Asp Glu Asp Ser Leu Thr Lys Gln Pro Glu Glu Val Phe Asp Val 
            20                  25                  30          


Leu Glu Lys Leu Gly Glu Gly Ser Tyr Gly Ser Val Tyr Lys Ala Ile 
        35                  40                  45              


His Lys Glu Thr Gly Gln Ile Val Ala Ile Lys Gln Val Pro Val Glu 
    50                  55                  60                  


Ser Asp Leu Gln Glu Ile Ile Lys Glu Ile Ser Ile Met Gln Gln Cys 
65                  70                  75                  80  


Asp Ser Pro His Val Val Lys Tyr Tyr Gly Ser Tyr Phe Lys Asn Thr 
                85                  90                  95      


Asp Leu Trp Ile Val Met Glu Tyr Cys Gly Ala Gly Ser Val Ser Asp 
            100                 105                 110         


Ile Ile Arg Leu Arg Asn Lys Thr Leu Thr Glu Asp Glu Ile Ala Thr 
        115                 120                 125             


Ile Leu Gln Ser Thr Leu Lys Gly Leu Glu Tyr Leu His Phe Met Arg 
    130                 135                 140                 


Lys Ile His Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Asn Thr Glu 
145                 150                 155                 160 


Gly His Ala Lys Leu Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp 
                165                 170                 175     


Thr Met Ala Lys Arg Asn Thr Val Ile Gly Thr Pro Phe Trp Met Ala 
            180                 185                 190         


Pro Glu Val Ile Gln Glu Ile Gly Tyr Asn Cys Val Ala Asp Ile Trp 
        195                 200                 205             


Ser Leu Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Lys Pro Pro Tyr 
    210                 215                 220                 


Ala Asp Ile His Pro Met Arg Ala Ile Phe Met Ile Pro Thr Asn Pro 
225                 230                 235                 240 


Pro Pro Thr Phe Arg Lys Pro Glu Leu Trp Ser Asp Asn Phe Thr Asp 
                245                 250                 255     


Phe Val Lys Gln Cys Leu Val Lys Ser Pro Glu Gln Arg Ala Thr Ala 
            260                 265                 270         


Thr Gln Leu Leu Gln His Pro Phe Val Arg Ser Ala Lys Gly Val Ser 
        275                 280                 285             


Ile Leu Arg Asp Leu Ile Asn Glu Ala Met Asp Val Lys Leu Lys Arg 
    290                 295                 300                 


Gln Glu Ser Gln Gln Arg Glu Val Asp Gln Asp Asp Glu Glu Asn Ser 
305                 310                 315                 320 


Glu Glu Asp Glu Met Asp Ser Gly Thr Met Val Arg Ala Val Gly Asp 
                325                 330                 335     


Glu Met Gly Thr Val Arg Val Ala Ser Thr Met Thr Asp Gly Ala Asn 
            340                 345                 350         


Thr Met Ile Glu His Asp Asp Thr Leu Pro Ser Gln Leu Gly Thr Met 
        355                 360                 365             


Val Ile Asn Ala Glu Asp Glu Glu Glu Glu Gly Thr Met Lys Arg Arg 
    370                 375                 380                 


Asp Glu Thr Met Gln Pro Ala Lys Pro Ser Phe Leu Glu Tyr Phe Glu 
385                 390                 395                 400 


Gln Lys Glu Lys Glu Asn Gln Ile Asn Ser Phe Gly Lys Ser Val Pro 
                405                 410                 415     


Gly Pro Leu Lys Asn Ser Ser Asp Trp Lys Ile Pro Gln Asp Gly Asp 
            420                 425                 430         


Tyr Glu Phe Leu Lys Ser Trp Thr Val Glu Asp Leu Gln Lys Arg Leu 
        435                 440                 445             


Leu Ala Leu Asp Pro Met Met Glu Gln Glu Ile Glu Glu Ile Arg Gln 
    450                 455                 460                 


Lys Tyr Gln Ser Lys Arg Gln Pro Ile Leu Asp Ala Ile Glu Ala Lys 
465                 470                 475                 480 


Lys Arg Arg Gln Gln Asn Phe 
                485         


<210>  619
<211>  2856
<212>  DNA
<213>  Homo sapiens

<400>  619
atggatggca gatggcaatg ttcctgctgg gcctggttcc tgctggttct ggcagttgta       60

gctggggaca cagtgtcaac cgggtccacg gacaacagcc caacatccaa tagcctggag      120

gggggcaccg acgccacggc cttctggtgg ggggagtgga ccaagtggac ggcgtgttcc      180

cgcagttgcg ggggtggggt gacatcccag gagcggcact gcctgcagca gaggaggaag      240

tccgtcccgg gccccgggaa caggacctgc acgggcacgt ccaagcggta ccagctctgc      300

agagtgcagg agtgtccgcc ggacgggagg agcttccgcg aggagcagtg cgtctccttc      360

aactcccacg tgtacaacgg gcggacgcac cagtggaagc ctctgtaccc ggatgactat      420

gtccacatct ccagcaaacc gtgtgacctg cactgtacca ccgtggacgg ccagcggcag      480

ctcatggtcc ccgcccgcga cggcacatcc tgcaagctca ctgacctgcg aggggtttgc      540

gtgtctggaa aatgtgagcc catcggctgt gacggggtgc ttttctccac ccacacactg      600

gacaagtgtg gcatctgcca gggggacggt agcagctgca cccacgtgac gggcaactat      660

cgcaagggga atgcccacct tggttactct ctggtgaccc acatcccggc tggtgcccga      720

gacatccaga ttgtagagag gaagaagtcc gctgacgtgc tagctcttgc agacgaagct      780

ggctactact tcttcaacgg caactacaag gtggacagcc ccaagaactt caacatcgca      840

ggcacggtgg tcaagtacag gcggcccatg gatgtctatg agaccggaat cgagtacatc      900

gtggcacagg ggcccaccaa ccagggcctg aatgtcatgg tgtggaacca gaacggcaaa      960

agcccctcca tcaccttcga gtacacgctg ctgcagccgc cacacgagag ccgcccccag     1020

cccatctact atggcttctc cgagagcgct gagagccagg gcctggacgg ggccgggctg     1080

atgggcttcg tcccgcacaa cggctccctc tacggccagg cctcctcaga gcggctgggc     1140

ctggacaacc ggctgttcgg ccacccgggc ctggacatgg agctgggccc cagccagggc     1200

caggagacca acgaggtgtg cgagcaggcc ggcggcgggg cctgcgaggg gccccccagg     1260

ggcaagggct tccgagaccg caacgtcacg gggactcctc tcaccgggga caaggatgac     1320

gaagaggttg acacccactt cgcctcccag gagttcttct cggctaacgc catctctgac     1380

cagctgctgg gcgcaggctc tgacttgaag gacttcaccc tcaatgagac tgtgaacagc     1440

atctttgcac agggcgcccc aaggagctcc ctggccgaga gcttcttcgt ggattatgag     1500

gagaacgagg gggctggccc ttacctgctc aacgggtcct acctggagct gagcagcgac     1560

agggttgcca acagctcctc cgaggcccca ttccccaacg ttagcaccag cctgctcacc     1620

tcggccggga acaggactca caaggccagg accaggccca aggcgcgcaa gcaaggcgtg     1680

agtcccgcgg acatgtaccg gtggaagctc tcgtcccacg agccctgcag tgccacctgc     1740

accacagggg tcatgtctgc gtacgccatg tgtgtccgct atgatggcgt cgaggtggat     1800

gacagctact gtgacgccct gacccgtccc gagcctgtcc acgagttctg cgctgggagg     1860

gagtgccagc ccaggtggga gacgagcagc tggagcgagt gttcgcgcac ctgcggagag     1920

ggctaccagt tccgcgtcgt gcgctgctgg aagatgctct cgcccggctt cgacagctcc     1980

gtgtacagcg acctgtgcga ggcagccgag gccgtgcggc ccgaggaacg caagacctgc     2040

cggaaccccg cctgcgggcc ccagtgggag atgtcggagt ggtccgagtg cactgccaag     2100

tgtggggagc gcagtgtggt gaccagggac atccgctgct cggaggatga gaagctgtgt     2160

gaccccaaca ccaggcctgt aggggagaag aactgcacgg gcccgccctg tgaccggcag     2220

tggaccgtct ccgactgggg accgtgcagt ggaagctgcg ggcaaggccg caccatcagg     2280

cacgtgtact gcaagaccag cgacggacgg gtagtacctg agtcccagtg ccagatggag     2340

accaagcctc tggccatcca cccctgtggg gacaaaaact gtcccgccca ctggctggcc     2400

caggactggg agcggtgcaa caccacctgc gggcgcgggg tcaagaagcg gctggtgctc     2460

tgcatggagc tggccaacgg gaagccgcag acgcgcagtg gccccgagtg cgggctcgcc     2520

aagaagcctc ccgaggagag cacgtgtttc gagaggccct gcttcaagtg gtacaccagc     2580

ccctggtcag agtgcaccaa gacctgcggg gtgggcgtga ggatgcgaga cgtcaagtgc     2640

taccagggga ccgacatcgt ccgtggttgc gatccgttgg tgaagcccgt tggcagacag     2700

gcctgtgatc tgcagccctg ccccacggag cccccagatg acagctgcca ggaccagcca     2760

ggcaccaact gtgccctggc catcaaagtg aacctctgcg ggcactggta ctacagcaag     2820

gcgtgctgcc gctcctgcag gcccccccac tcctag                               2856


<210>  620
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  620

Met Asp Gly Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val 
1               5                   10                  15      


Leu Ala Val Val Ala Gly Asp Thr Val Ser Thr Gly Ser Thr Asp Asn 
            20                  25                  30          


Ser Pro Thr Ser Asn Ser Leu Glu Gly Gly Thr Asp Ala Thr Ala Phe 
        35                  40                  45              


Trp Trp Gly Glu Trp Thr Lys Trp Thr Ala Cys Ser Arg Ser Cys Gly 
    50                  55                  60                  


Gly Gly Val Thr Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys 
65                  70                  75                  80  


Ser Val Pro Gly Pro Gly Asn Arg Thr Cys Thr Gly Thr Ser Lys Arg 
                85                  90                  95      


Tyr Gln Leu Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe 
            100                 105                 110         


Arg Glu Glu Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg 
        115                 120                 125             


Thr His Gln Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser 
    130                 135                 140                 


Ser Lys Pro Cys Asp Leu His Cys Thr Thr Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Leu Met Val Pro Ala Arg Asp Gly Thr Ser Cys Lys Leu Thr Asp Leu 
                165                 170                 175     


Arg Gly Val Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly 
            180                 185                 190         


Val Leu Phe Ser Thr His Thr Leu Asp Lys Cys Gly Ile Cys Gln Gly 
        195                 200                 205             


Asp Gly Ser Ser Cys Thr His Val Thr Gly Asn Tyr Arg Lys Gly Asn 
    210                 215                 220                 


Ala His Leu Gly Tyr Ser Leu Val Thr His Ile Pro Ala Gly Ala Arg 
225                 230                 235                 240 


Asp Ile Gln Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu 
                245                 250                 255     


Ala Asp Glu Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp 
            260                 265                 270         


Ser Pro Lys Asn Phe Asn Ile Ala Gly Thr Val Val Lys Tyr Arg Arg 
        275                 280                 285             


Pro Met Asp Val Tyr Glu Thr Gly Ile Glu Tyr Ile Val Ala Gln Gly 
    290                 295                 300                 


Pro Thr Asn Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys 
305                 310                 315                 320 


Ser Pro Ser Ile Thr Phe Glu Tyr Thr Leu Leu Gln Pro Pro His Glu 
                325                 330                 335     


Ser Arg Pro Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser 
            340                 345                 350         


Gln Gly Leu Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly 
        355                 360                 365             


Ser Leu Tyr Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg 
    370                 375                 380                 


Leu Phe Gly His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly 
385                 390                 395                 400 


Gln Glu Thr Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu 
                405                 410                 415     


Gly Pro Pro Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Thr Gly Thr 
            420                 425                 430         


Pro Leu Thr Gly Asp Lys Asp Asp Glu Glu Val Asp Thr His Phe Ala 
        435                 440                 445             


Ser Gln Glu Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly 
    450                 455                 460                 


Ala Gly Ser Asp Leu Lys Asp Phe Thr Leu Asn Glu Thr Val Asn Ser 
465                 470                 475                 480 


Ile Phe Ala Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe 
                485                 490                 495     


Val Asp Tyr Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly 
            500                 505                 510         


Ser Tyr Leu Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu 
        515                 520                 525             


Ala Pro Phe Pro Asn Val Ser Thr Ser Leu Leu Thr Ser Ala Gly Asn 
    530                 535                 540                 


Arg Thr His Lys Ala Arg Thr Arg Pro Lys Ala Arg Lys Gln Gly Val 
545                 550                 555                 560 


Ser Pro Ala Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys 
                565                 570                 575     


Ser Ala Thr Cys Thr Thr Gly Val Met Ser Ala Tyr Ala Met Cys Val 
            580                 585                 590         


Arg Tyr Asp Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Thr 
        595                 600                 605             


Arg Pro Glu Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro 
    610                 615                 620                 


Arg Trp Glu Thr Ser Ser Trp Ser Glu Cys Ser Arg Thr Cys Gly Glu 
625                 630                 635                 640 


Gly Tyr Gln Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly 
                645                 650                 655     


Phe Asp Ser Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val 
            660                 665                 670         


Arg Pro Glu Glu Arg Lys Thr Cys Arg Asn Pro Ala Cys Gly Pro Gln 
        675                 680                 685             


Trp Glu Met Ser Glu Trp Ser Glu Cys Thr Ala Lys Cys Gly Glu Arg 
    690                 695                 700                 


Ser Val Val Thr Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys 
705                 710                 715                 720 


Asp Pro Asn Thr Arg Pro Val Gly Glu Lys Asn Cys Thr Gly Pro Pro 
                725                 730                 735     


Cys Asp Arg Gln Trp Thr Val Ser Asp Trp Gly Pro Cys Ser Gly Ser 
            740                 745                 750         


Cys Gly Gln Gly Arg Thr Ile Arg His Val Tyr Cys Lys Thr Ser Asp 
        755                 760                 765             


Gly Arg Val Val Pro Glu Ser Gln Cys Gln Met Glu Thr Lys Pro Leu 
    770                 775                 780                 


Ala Ile His Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala 
785                 790                 795                 800 


Gln Asp Trp Glu Arg Cys Asn Thr Thr Cys Gly Arg Gly Val Lys Lys 
                805                 810                 815     


Arg Leu Val Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Thr Arg 
            820                 825                 830         


Ser Gly Pro Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Thr 
        835                 840                 845             


Cys Phe Glu Arg Pro Cys Phe Lys Trp Tyr Thr Ser Pro Trp Ser Glu 
    850                 855                 860                 


Cys Thr Lys Thr Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys 
865                 870                 875                 880 


Tyr Gln Gly Thr Asp Ile Val Arg Gly Cys Asp Pro Leu Val Lys Pro 
                885                 890                 895     


Val Gly Arg Gln Ala Cys Asp Leu Gln Pro Cys Pro Thr Glu Pro Pro 
            900                 905                 910         


Asp Asp Ser Cys Gln Asp Gln Pro Gly Thr Asn Cys Ala Leu Ala Ile 
        915                 920                 925             


Lys Val Asn Leu Cys Gly His Trp Tyr Tyr Ser Lys Ala Cys Cys Arg 
    930                 935                 940                 


Ser Cys Arg Pro Pro His Ser 
945                 950     


<210>  621
<211>  588
<212>  DNA
<213>  Homo sapiens

<400>  621
atgtctctca tctcatggct tcggtggaac gaggccccat cccggctgtc caccaggagc       60

cctgctgaga tggtgctgga gacgcttatg atggagctga cggggcagat gcgagaggct      120

gagaggcagc agcgggagcg cagcaatgcg gtcagaaagg tctgcaccgg tgtggactac      180

agctggctgg ccagcacacc ccggtccacc tatgacctca gccccattga gcggttgcag      240

ctggaagatg tctgcgttaa gatccaccca tcctattgtg ggcctgctat cctcaggttc      300

cggcagctgc tggcggagca ggagcccgag gtgcaggagg tgtcccagct cttccgctcg      360

gtgctgcagg aggtcctgga gaggatgaag caggaagagg aggcccacaa gctgacgcgc      420

cagtggagcc tgcggccccg cggcagcctg gccaccttca agacccgcgc gcgcatctcg      480

cccttcgcca gcgacatcag gaccatctcc gaggacgtgg agcgggacac accgccgcca      540

ctgcggtcct ggagcatgcc cgaattccgg gcgcccaaag ccgactga                   588


<210>  622
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  622

Met Ser Leu Ile Ser Trp Leu Arg Trp Asn Glu Ala Pro Ser Arg Leu 
1               5                   10                  15      


Ser Thr Arg Ser Pro Ala Glu Met Val Leu Glu Thr Leu Met Met Glu 
            20                  25                  30          


Leu Thr Gly Gln Met Arg Glu Ala Glu Arg Gln Gln Arg Glu Arg Ser 
        35                  40                  45              


Asn Ala Val Arg Lys Val Cys Thr Gly Val Asp Tyr Ser Trp Leu Ala 
    50                  55                  60                  


Ser Thr Pro Arg Ser Thr Tyr Asp Leu Ser Pro Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Cys Val Lys Ile His Pro Ser Tyr Cys Gly Pro Ala 
                85                  90                  95      


Ile Leu Arg Phe Arg Gln Leu Leu Ala Glu Gln Glu Pro Glu Val Gln 
            100                 105                 110         


Glu Val Ser Gln Leu Phe Arg Ser Val Leu Gln Glu Val Leu Glu Arg 
        115                 120                 125             


Met Lys Gln Glu Glu Glu Ala His Lys Leu Thr Arg Gln Trp Ser Leu 
    130                 135                 140                 


Arg Pro Arg Gly Ser Leu Ala Thr Phe Lys Thr Arg Ala Arg Ile Ser 
145                 150                 155                 160 


Pro Phe Ala Ser Asp Ile Arg Thr Ile Ser Glu Asp Val Glu Arg Asp 
                165                 170                 175     


Thr Pro Pro Pro Leu Arg Ser Trp Ser Met Pro Glu Phe Arg Ala Pro 
            180                 185                 190         


Lys Ala Asp 
        195 


<210>  623
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  623
atggctaggg tactgggagc acccgttgca ctggggttgt ggagcctatg ctggtctctg       60

gccattgcca cccctcttcc tccgactagt gcccatggga atgttgctga aggcgagacc      120

aagccagacc cagacgtgac tgaacgctgc tcagatggct ggagctttga tgctaccacc      180

ctggatgaca atggaaccat gctgtttttt aaaggggagt ttgtgtggaa gagtcacaaa      240

tgggaccggg agttaatctc agagagatgg aagaatttcc ccagccctgt ggatgctgca      300

ttccgtcaag gtcacaacag tgtctttctg atcaaggggg acaaagtctg ggtataccct      360

cctgaaaaga aggagaaagg atacccaaag ttgctccaag atgaatttcc tggaatccca      420

tccccactgg atgcagctgt ggaatgtcac cgtggagaat gtcaagctga aggcgtcctc      480

ttcttccaag gtgaccgcga gtggttctgg gacttggcta cgggaaccat gaaggagcgt      540

tcctggccag ctgttgggaa ctgctcctct gccctgagat ggctgggccg ctactactgc      600

ttccagggta accaattcct gcgcttcgac cctgtcaggg gagaggtgcc tcccaggtac      660

ccgcgggatg tccgagacta cttcatgccc tgccctggca gaggccatgg acacaggaat      720

gggactggcc atgggaacag tacccaccat ggccctgagt atatgcgctg tagcccacat      780

ctagtcttgt ctgcactgac gtctgacaac catggtgcca cctatgcctt cagtgggacc      840

cactactggc gtctggacac cagccgggat ggctggcata gctggcccat tgctcatcag      900

tggccccagg gtccttcagc agtggatgct gccttttcct gggaagaaaa actctatctg      960

gtccagggca cccaggtata tgtcttcctg acaaagggag gctataccct agtaagcggt     1020

tatccgaagc ggctggagaa ggaagtcggg acccctcatg ggattatcct ggactctgtg     1080

gatgcggcct ttatctgccc tgggtcttct cggctccata tcatggcagg acggcggctg     1140

tggtggctgg acctgaagtc aggagcccaa gccacgtgga cagagcttcc ttggccccat     1200

gagaaggtag acggagcctt gtgtatggaa aagtcccttg gccctaactc atgttccgcc     1260

aatggtcccg gcttgtacct catccatggt cccaatttgt actgctacag tgatgtggag     1320

aaactgaatg cagccaaggc ccttccgcaa ccccagaatg tgaccagtct cctgggctgc     1380

actcactga                                                             1389


<210>  624
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  624

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  625
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  625
atggctacga aatgtgggaa ttgtggaccc ggctactcca cccctctgga ggccatgaaa       60

ggacccaggg aagagatcgt ctacctgccc tgcatttacc gaaacacagg cactgaggcc      120

ccagattatc tggccactgt ggatgttgac cccaagtctc cccagtattg ccaggtcatc      180

caccggctgc ccatgcccaa cctgaaggac gagctgcatc actcaggatg gaacacctgc      240

agcagctgct tcggtgatag caccaagtcg cgcaccaagc tggtgctgcc cagtctcatc      300

tcctctcgca tctatgtggt ggacgtgggc tctgagcccc gggccccaaa gctgcacaag      360

gtcattgagc ccaaggacat ccatgccaag tgcgaactgg cctttctcca caccagccac      420

tgcctggcca gcggggaagt gatgatcagc tccctgggag acgtcaaggg caatggcaaa      480

gggggttttg tgctgctgga tggggagacg ttcgaggtga aggggacatg ggagagacct      540

gggggtgctg caccgttggg ctatgacttc tggtaccagc ctcgacacaa tgtcatgatc      600

agcactgagt gggcagctcc caatgtctta cgagatggct tcaaccccgc tgatgtggag      660

gctggactgt acgggagcca cttatatgta tgggactggc agcgccatga gattgtgcag      720

accctgtctc taaaagatgg gcttattccc ttggagatcc gcttcctgca caacccagac      780

gctgcccaag gctttgtggg ctgcgcactc agctccacca tccagcgctt ctacaagaac      840

gagggaggta catggtcagt ggagaaggtg atccaggtgc cccccaagaa agtgaagggc      900

tggctgctgc ccgaaatgcc aggcctgatc accgacatcc tgctctccct ggacgaccgc      960

ttcctctact tcagcaactg gctgcatggg gacctgaggc agtatgacat ctctgaccca     1020

cagagacccc gcctcacagg acagctcttc ctcggaggca gcattgttaa gggaggccct     1080

gtgcaagtgc tggaggacga ggaactaaag tcccagccag agcccctagt ggtcaaggga     1140

aaacgggtgg ctggaggccc tcagatgatc cagctcagcc tggatgggaa gcgcctctac     1200

atcaccacgt cgctgtacag tgcctgggac aagcagtttt accctgatct catcagggaa     1260

ggctctgtga tgctgcaggt tgatgtagac acagtaaaag gagggctgaa gttgaacccc     1320

aacttcctgg tggacttcgg gaaggagccc cttggcccag cccttgccca tgagctccgc     1380

taccctgggg gcgattgtag ctctgacatc tggatttga                            1419


<210>  626
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Ala Thr Lys Cys Gly Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu 
1               5                   10                  15      


Glu Ala Met Lys Gly Pro Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile 
            20                  25                  30          


Tyr Arg Asn Thr Gly Thr Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp 
        35                  40                  45              


Val Asp Pro Lys Ser Pro Gln Tyr Cys Gln Val Ile His Arg Leu Pro 
    50                  55                  60                  


Met Pro Asn Leu Lys Asp Glu Leu His His Ser Gly Trp Asn Thr Cys 
65                  70                  75                  80  


Ser Ser Cys Phe Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val Leu 
                85                  90                  95      


Pro Ser Leu Ile Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser Glu 
            100                 105                 110         


Pro Arg Ala Pro Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile His 
        115                 120                 125             


Ala Lys Cys Glu Leu Ala Phe Leu His Thr Ser His Cys Leu Ala Ser 
    130                 135                 140                 


Gly Glu Val Met Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly Lys 
145                 150                 155                 160 


Gly Gly Phe Val Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly Thr 
                165                 170                 175     


Trp Glu Arg Pro Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr 
            180                 185                 190         


Gln Pro Arg His Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro Asn 
        195                 200                 205             


Val Leu Arg Asp Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr 
    210                 215                 220                 


Gly Ser His Leu Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val Gln 
225                 230                 235                 240 


Thr Leu Ser Leu Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu 
                245                 250                 255     


His Asn Pro Asp Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser Ser 
            260                 265                 270         


Thr Ile Gln Arg Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val Glu 
        275                 280                 285             


Lys Val Ile Gln Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu Pro 
    290                 295                 300                 


Glu Met Pro Gly Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg 
305                 310                 315                 320 


Phe Leu Tyr Phe Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr Asp 
                325                 330                 335     


Ile Ser Asp Pro Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly 
            340                 345                 350         


Gly Ser Ile Val Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu Glu 
        355                 360                 365             


Leu Lys Ser Gln Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val Ala 
    370                 375                 380                 


Gly Gly Pro Gln Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr 
385                 390                 395                 400 


Ile Thr Thr Ser Leu Tyr Ser Ala Trp Asp Lys Gln Phe Tyr Pro Asp 
                405                 410                 415     


Leu Ile Arg Glu Gly Ser Val Met Leu Gln Val Asp Val Asp Thr Val 
            420                 425                 430         


Lys Gly Gly Leu Lys Leu Asn Pro Asn Phe Leu Val Asp Phe Gly Lys 
        435                 440                 445             


Glu Pro Leu Gly Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly Gly 
    450                 455                 460                 


Asp Cys Ser Ser Asp Ile Trp Ile 
465                 470         


<210>  627
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  627
atggcgggat cagtggccga cagcgatgcc gtggtgaaac tagatgatgg ccatttaaac       60

aactctttga gctctccagt tcaagcggac gtgtacttcc cacgactgat agttccattt      120

tgtgggcaca ttaaaggtgg catgagacca ggcaagaagg tgttagtgat gggcatcgta      180

gacctcaacc cagagagctt tgcaatcagc ttgacctgtg gggactcaga agaccctcct      240

gccgatgtgg caatcgaact caaagctgtg ttcacagatc ggcagctact cagaaattct      300

tgtatatctg gggagagggg tgaagaacag tcagcaatcc cttactttcc attcattcca      360

gaccagccat tcagggtgga aattctttgt gagcacccac gtttccgagt gtttgtggat      420

ggacaccaac tttttgattt ttaccatcgc attcaaacgt tatctgcaat tgacaccata      480

aagataaatg gagacctcca gatcaccaag cttggctga                             519


<210>  628
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Ala Gly Ser Val Ala Asp Ser Asp Ala Val Val Lys Leu Asp Asp 
1               5                   10                  15      


Gly His Leu Asn Asn Ser Leu Ser Ser Pro Val Gln Ala Asp Val Tyr 
            20                  25                  30          


Phe Pro Arg Leu Ile Val Pro Phe Cys Gly His Ile Lys Gly Gly Met 
        35                  40                  45              


Arg Pro Gly Lys Lys Val Leu Val Met Gly Ile Val Asp Leu Asn Pro 
    50                  55                  60                  


Glu Ser Phe Ala Ile Ser Leu Thr Cys Gly Asp Ser Glu Asp Pro Pro 
65                  70                  75                  80  


Ala Asp Val Ala Ile Glu Leu Lys Ala Val Phe Thr Asp Arg Gln Leu 
                85                  90                  95      


Leu Arg Asn Ser Cys Ile Ser Gly Glu Arg Gly Glu Glu Gln Ser Ala 
            100                 105                 110         


Ile Pro Tyr Phe Pro Phe Ile Pro Asp Gln Pro Phe Arg Val Glu Ile 
        115                 120                 125             


Leu Cys Glu His Pro Arg Phe Arg Val Phe Val Asp Gly His Gln Leu 
    130                 135                 140                 


Phe Asp Phe Tyr His Arg Ile Gln Thr Leu Ser Ala Ile Asp Thr Ile 
145                 150                 155                 160 


Lys Ile Asn Gly Asp Leu Gln Ile Thr Lys Leu Gly 
                165                 170         


<210>  629
<211>  243
<212>  DNA
<213>  Homo sapiens

<400>  629
atgggcagca cgctgaggaa acgcaagatg tacgaggagt tcctcagcaa ggtctccatc       60

ctagagtccc tggagaagtg ggagcgtctg accgtggcgg atgcgctgga gcccgtccag      120

tttgaagatg gagagaaaat cgtggtccag ggagagcctg gggacgactt ttacatcatc      180

acggagaaaa atttgccggg tgtggtggca catgcctgta atcccagcta cttgggaggc      240

tga                                                                    243


<210>  630
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Gly Ser Thr Leu Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser 
1               5                   10                  15      


Lys Val Ser Ile Leu Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val 
            20                  25                  30          


Ala Asp Ala Leu Glu Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val 
        35                  40                  45              


Val Gln Gly Glu Pro Gly Asp Asp Phe Tyr Ile Ile Thr Glu Lys Asn 
    50                  55                  60                  


Leu Pro Gly Val Val Ala His Ala Cys Asn Pro Ser Tyr Leu Gly Gly 
65                  70                  75                  80  


<210>  631
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  631
atggagaacc tgggggtcgg cgaaggggca gaggcttgca gcaggttgag tcgctctcgc       60

ggccgccaca gcatgaccag agccccgaag cacctgtggc ggcaaccccg gcgccccatc      120

cgcatccaac agcgcttcta ttcggatccg gacaagtccg cgggctgccg cgagagggac      180

ctgagcccgc ggccggagct caggaagtcg cggctctcct ggcccgtttc ctcctgcagg      240

cgctttgacc tggaaaatgg gctctcgtgt gggaggaggg ccctggaccc tcagtccagc      300

cctggcctgg gccggattat gcaggctcca gtcccgcaca gccagcggcg cgagtccttc      360

ctgtaccgct cagatagcga ctatgaactc tcgcccaagg ccatgtctcg gaactcctct      420

gtggccagcg acctacatgg agaggacatg attgtgacgc cctttgccca ggtcctggcc      480

agtctgcgga ccgttcggag caacgtggcg gcccttgccc gccagcaatg cctaggagca      540

gccaagcagg gacccgtcgg aaacccttca tccagcaatc agctccctcc tgcagaggac      600

acggggcaga agctggcatt ggagacgcta gacgagctgg actggtgcct ggatcagttg      660

gagacgctgc agacccggca ctcggtgggg gagatggcct ccaacaagtt caagcggatc      720

ctgaaccggg agttgaccca cctgtccgaa accagccgct ccgggaacca ggtgtccgag      780

tacatctccc ggaccttcct ggaccagcag accgaggtgg agctgcccaa ggtgaccgct      840

gaggaggccc cacagcccat gtcccggatc agtggcctac atgggctctg ccacagtgcc      900

agcctctcct cagccactgt cccacgcttt ggggtccaga ctgaccagga ggagcaactg      960

gccaaggagc tagaagacac caacaagtgg ggacttgatg tgttcaaggt ggcggagcta     1020

agtgggaacc ggcccctcac agctatcata ttcagcattt ttcaggagcg ggacctgctg     1080

aagacattcc agatcccagc agacacactg gccacctacc tgctgatgct ggaaggtcac     1140

taccacgcca atgtggccta ccacaacagc ctacatgccg ccgacgtggc ccagtccacg     1200

catgtgctgc tggctacgcc cgccctcgag gctgtgttca cagacttgga aatcctggct     1260

gccctctttg caagcgccat ccacgacgtg gaccatcctg gggtctccaa ccagtttctg     1320

attaacacca actcagagct ggcgcttatg tacaacgacg cctcggtgct ggagaaccat     1380

cacctggctg tgggcttcaa gctgctgcag gcagagaact gcgatatctt ccagaacctc     1440

agcgccaagc agcgactgag tctgcgcagg atggtcattg acatggtgct ggccacagac     1500

atgtccaaac acatgaacct cctggccgac ctcaagacca tggtggagac caagaaggtg     1560

acaagcctcg gtgtcctcct cctggacaac tattccgacc gaatccaggt cttgcagaac     1620

ctggtgcact gtgctgatct gagcaacccc accaagccgc tgcccctgta ccgccagtgg     1680

acggaccgca tcatggccga gttcttccag cagggagacc gcgagcgtga gtcgggcctg     1740

gacatcagtc ccatgtgtga caagcatacg gcctcagtgg agaagtccca ggtgggtttc     1800

attgactaca ttgctcaccc actgtgggag acttgggctg acctggtcca cccagatgca     1860

caggacctgc tggacacgct ggaggacaat cgagagtggt accagagcaa gatcccccga     1920

agtccctcag acctcaccaa ccccgagcgg gacgggcctg acagattcca gtttgaactg     1980

actctggagg aggcagagga agaggatgag gaggaagaag aggaggggga agagacagct     2040

ttagccaaag aggccttgga gttgcctgac actgaactcc tgtcccctga agccggccca     2100

gaccctgggg acttacccct cgacaaccag aggacttag                            2139


<210>  632
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Glu Asn Leu Gly Val Gly Glu Gly Ala Glu Ala Cys Ser Arg Leu 
1               5                   10                  15      


Ser Arg Ser Arg Gly Arg His Ser Met Thr Arg Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg Gln Pro Arg Arg Pro Ile Arg Ile Gln Gln Arg Phe Tyr Ser 
        35                  40                  45              


Asp Pro Asp Lys Ser Ala Gly Cys Arg Glu Arg Asp Leu Ser Pro Arg 
    50                  55                  60                  


Pro Glu Leu Arg Lys Ser Arg Leu Ser Trp Pro Val Ser Ser Cys Arg 
65                  70                  75                  80  


Arg Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp 
                85                  90                  95      


Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro 
            100                 105                 110         


His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr 
        115                 120                 125             


Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp 
    130                 135                 140                 


Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala 
145                 150                 155                 160 


Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln 
                165                 170                 175     


Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser 
            180                 185                 190         


Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu 
        195                 200                 205             


Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln 
    210                 215                 220                 


Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile 
225                 230                 235                 240 


Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn 
                245                 250                 255     


Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu 
            260                 265                 270         


Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser 
        275                 280                 285             


Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser 
    290                 295                 300                 


Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu 
305                 310                 315                 320 


Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys 
                325                 330                 335     


Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser 
            340                 345                 350         


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp 
        355                 360                 365             


Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn 
    370                 375                 380                 


Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr 
385                 390                 395                 400 


His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
                405                 410                 415     


Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His 
            420                 425                 430         


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
        435                 440                 445             


Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val 
    450                 455                 460                 


Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu 
465                 470                 475                 480 


Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val 
                485                 490                 495     


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
            500                 505                 510         


Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys 
    530                 535                 540                 


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp 
545                 550                 555                 560 


Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg 
                565                 570                 575     


Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser 
            580                 585                 590         


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu 
        595                 600                 605             


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu 
    610                 615                 620                 


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg 
625                 630                 635                 640 


Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe 
                645                 650                 655     


Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu 
        675                 680                 685             


Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp 
    690                 695                 700                 


Leu Pro Leu Asp Asn Gln Arg Thr 
705                 710         


<210>  633
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  633
atgggatccg gctcctccag ctaccggccc aaggccatct acctggacat cgatggacgc       60

attcagaagg taatcttcag caagtactgc aactccagcg acatcatgga cctgttctgc      120

atcgccaccg gcctgcctcg gaacacgacc atctccctgc tgaccaccga cgacgccatg      180

gtctccatcg accccaccat gcccgcgaat tcagaacgca ctccgtacaa agtgagacct      240

gtggccatca agcaactctc cgctggtgtc gaggacaaga gaaccacaag ccgtggccag      300

tctgctgaga gaccactgag ggacagacgg gttgtgggcc tggagcagcc ccggagggaa      360

ggagcatttg aaagtggaca ggtagagccc aggcccagag agccccaggg ctgctaccag      420

gaaggccagc gcatccctcc agagagagaa gaattaatcc agagcgtgct ggcgcaggtt      480

gcagagcagt tctcaagagc attcaaaatc aatgaactga aagctgaagt tgcaaatcac      540

ttggctgtcc tagagaaacg cgtggaattg gaaggactaa aagtggtgga gattgagaaa      600

tgcaagagtg acattaagaa gatgagggag gagctggcgg ccagaagcag caggaccaac      660

tgcccctgta agtacagttt tttggataac cacaagaagt tgactcctcg acgcgatgtt      720

cccacttacc ccaagtacct gctctctcca gagaccatcg aggccctgcg gaagccgacc      780

tttgacgtct ggctttggga gcccaatgag atgctgagct gcctggagca catgtaccac      840

gacctcgggc tggtcaggga cttcagcatc aaccctgtca ccctcaggag gtggctgttc      900

tgcgtccacg acaactacag aaacaacccc ttccacaact tccggcactg cttctgcgtg      960

gcccagatga tgtacagcat ggtctggctc tgcagtctcc aggagaagtt ctcacaaacg     1020

gatatcctga tcctaatgac agcggccatc tgccacgatc tggaccatcc cggctacaac     1080

aacacgtacc agatcaatgc ccgcacagag ctggcggtcc gctacaatga catctcaccg     1140

ctggagaacc accactgcgc cgtggccttc cagatcctcg ccgagcctga gtgcaacatc     1200

ttctccaaca tcccacctga tgggttcaag cagatccgac agggaatgat cacattaatc     1260

ttggccactg acatggcaag acatgcagaa attatggatt ctttcaaaga gaaaatggag     1320

aattttgact acagcaacga ggagcacatg accctgctga agatgatttt gataaaatgc     1380

tgtgatatct ctaacgaggt ccgtccaatg gaagtcgcag agccttgggt ggactgttta     1440

ttagaggaat attttatgca gagcgaccgt gagaagtcag aaggccttcc tgtggcaccg     1500

ttcatggacc gagacaaagt gaccaaggcc acagcccaga ttgggttcat caagtttgtc     1560

ctgatcccaa tgtttgaaac agtgaccaag ctcttcccca tggttgagga gatcatgctg     1620

cagccacttt gggaatcccg agatcgctac gaggagctga agcggataga tgacgccatg     1680

aaagagttac agaagaagac tgacagcttg acgtctgggg ccaccgagaa gtccagagag     1740

agaagcagag atgtgaaaaa cagtgaagga gactgtgcct ga                        1782


<210>  634
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Gly Ser Gly Ser Ser Ser Tyr Arg Pro Lys Ala Ile Tyr Leu Asp 
1               5                   10                  15      


Ile Asp Gly Arg Ile Gln Lys Val Ile Phe Ser Lys Tyr Cys Asn Ser 
            20                  25                  30          


Ser Asp Ile Met Asp Leu Phe Cys Ile Ala Thr Gly Leu Pro Arg Asn 
        35                  40                  45              


Thr Thr Ile Ser Leu Leu Thr Thr Asp Asp Ala Met Val Ser Ile Asp 
    50                  55                  60                  


Pro Thr Met Pro Ala Asn Ser Glu Arg Thr Pro Tyr Lys Val Arg Pro 
65                  70                  75                  80  


Val Ala Ile Lys Gln Leu Ser Ala Gly Val Glu Asp Lys Arg Thr Thr 
                85                  90                  95      


Ser Arg Gly Gln Ser Ala Glu Arg Pro Leu Arg Asp Arg Arg Val Val 
            100                 105                 110         


Gly Leu Glu Gln Pro Arg Arg Glu Gly Ala Phe Glu Ser Gly Gln Val 
        115                 120                 125             


Glu Pro Arg Pro Arg Glu Pro Gln Gly Cys Tyr Gln Glu Gly Gln Arg 
    130                 135                 140                 


Ile Pro Pro Glu Arg Glu Glu Leu Ile Gln Ser Val Leu Ala Gln Val 
145                 150                 155                 160 


Ala Glu Gln Phe Ser Arg Ala Phe Lys Ile Asn Glu Leu Lys Ala Glu 
                165                 170                 175     


Val Ala Asn His Leu Ala Val Leu Glu Lys Arg Val Glu Leu Glu Gly 
            180                 185                 190         


Leu Lys Val Val Glu Ile Glu Lys Cys Lys Ser Asp Ile Lys Lys Met 
        195                 200                 205             


Arg Glu Glu Leu Ala Ala Arg Ser Ser Arg Thr Asn Cys Pro Cys Lys 
    210                 215                 220                 


Tyr Ser Phe Leu Asp Asn His Lys Lys Leu Thr Pro Arg Arg Asp Val 
225                 230                 235                 240 


Pro Thr Tyr Pro Lys Tyr Leu Leu Ser Pro Glu Thr Ile Glu Ala Leu 
                245                 250                 255     


Arg Lys Pro Thr Phe Asp Val Trp Leu Trp Glu Pro Asn Glu Met Leu 
            260                 265                 270         


Ser Cys Leu Glu His Met Tyr His Asp Leu Gly Leu Val Arg Asp Phe 
        275                 280                 285             


Ser Ile Asn Pro Val Thr Leu Arg Arg Trp Leu Phe Cys Val His Asp 
    290                 295                 300                 


Asn Tyr Arg Asn Asn Pro Phe His Asn Phe Arg His Cys Phe Cys Val 
305                 310                 315                 320 


Ala Gln Met Met Tyr Ser Met Val Trp Leu Cys Ser Leu Gln Glu Lys 
                325                 330                 335     


Phe Ser Gln Thr Asp Ile Leu Ile Leu Met Thr Ala Ala Ile Cys His 
            340                 345                 350         


Asp Leu Asp His Pro Gly Tyr Asn Asn Thr Tyr Gln Ile Asn Ala Arg 
        355                 360                 365             


Thr Glu Leu Ala Val Arg Tyr Asn Asp Ile Ser Pro Leu Glu Asn His 
    370                 375                 380                 


His Cys Ala Val Ala Phe Gln Ile Leu Ala Glu Pro Glu Cys Asn Ile 
385                 390                 395                 400 


Phe Ser Asn Ile Pro Pro Asp Gly Phe Lys Gln Ile Arg Gln Gly Met 
                405                 410                 415     


Ile Thr Leu Ile Leu Ala Thr Asp Met Ala Arg His Ala Glu Ile Met 
            420                 425                 430         


Asp Ser Phe Lys Glu Lys Met Glu Asn Phe Asp Tyr Ser Asn Glu Glu 
        435                 440                 445             


His Met Thr Leu Leu Lys Met Ile Leu Ile Lys Cys Cys Asp Ile Ser 
    450                 455                 460                 


Asn Glu Val Arg Pro Met Glu Val Ala Glu Pro Trp Val Asp Cys Leu 
465                 470                 475                 480 


Leu Glu Glu Tyr Phe Met Gln Ser Asp Arg Glu Lys Ser Glu Gly Leu 
                485                 490                 495     


Pro Val Ala Pro Phe Met Asp Arg Asp Lys Val Thr Lys Ala Thr Ala 
            500                 505                 510         


Gln Ile Gly Phe Ile Lys Phe Val Leu Ile Pro Met Phe Glu Thr Val 
        515                 520                 525             


Thr Lys Leu Phe Pro Met Val Glu Glu Ile Met Leu Gln Pro Leu Trp 
    530                 535                 540                 


Glu Ser Arg Asp Arg Tyr Glu Glu Leu Lys Arg Ile Asp Asp Ala Met 
545                 550                 555                 560 


Lys Glu Leu Gln Lys Lys Thr Asp Ser Leu Thr Ser Gly Ala Thr Glu 
                565                 570                 575     


Lys Ser Arg Glu Arg Ser Arg Asp Val Lys Asn Ser Glu Gly Asp Cys 
            580                 585                 590         


Ala 
    


<210>  635
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  635
atgagagctg cacccctcct cctggccagg gcagcaagcc ttagccttgg cttcttgttt       60

ctgctttttt tctggctaga ccgaagtgta ctagccaagg agttgaagtt tgtgactttg      120

gtgtttcggc atggagaccg aagtcccatt gacacctttc ccactgaccc cataaaggaa      180

tcctcatggc cacaaggatt tggccaactc acccagctgg gcatggagca gcattatgaa      240

cttggagagt atataagaaa gagatataga aaattcttga atgagtccta taaacatgaa      300

caggtttata ttcgaagcac agacgttgac cggactttga tgagtgctat gacaaacctg      360

gcagccctgt ttcccccaga aggtgtcagc atctggaatc ctatcctact ctggcagccc      420

atcccggtgc acacagttcc tctttctgaa gatcagttgc tatacctgcc tttcaggaac      480

tgccctcgtt ttcaagaact tgagagtgag actttgaaat cagaggaatt ccagaagagg      540

ctgcaccctt ataaggattt tatagctacc ttgggaaaac tttcaggatt acatggccag      600

gacctttttg gaatttggag taaagtctac gaccctttat attgtgagag tgttcacaat      660

ttcactttac cctcctgggc cactgaggac accatgacta agttgagaga attgtcagaa      720

ttgtccctcc tgtccctcta tggaattcac aagcagaaag agaaatctag gctccaaggg      780

ggtgtcctgg tcaatgaaat cctcaatcac atgaagagag caactcagat accaagctac      840

aaaaaactca tcatgtattc tgcgcatgac actactgtga gtggcctaca gatggcgcta      900

gatgtttaca acggactcct tcctccctat gcttcttgcc acttgacgga attgtacttt      960

gagaaggggg agtactttgt ggagatgtac tatcggaatg agacgcagca cgagccgtat     1020

cccctcatgc tacctggctg cagccccagc tgtcctctgg agaggtttgc tgagctggtt     1080

ggccctgtga tccctcaaga ctggtccacg gagtgtatga ccacaaacag ccatcaaggt     1140

actgaagaca gtacagatta g                                               1161


<210>  636
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  637
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  637
atgtgcgacg aagacgagac caccgccctc gtgtgcgaca atggctccgg cctggtgaaa       60

gccggcttcg ccggggatga cgcccctagg gccgtgttcc cgtccatcgt gggccgcccc      120

cgacaccagg gcgtcatggt cggtatgggt cagaaagatt cctacgtggg cgacgaggct      180

cagagcaaga gaggtatcct gaccctgaag taccctatcg agcacggcat catcaccaac      240

tgggatgaca tggagaagat ctggcaccac accttctaca acgagcttcg cgtggctccc      300

gaggagcacc ccaccctgct caccgaggcc cccctcaatc ccaaggccaa ccgcgagaag      360

atgacccaga tcatgtttga gaccttcaac gtgcccgcca tgtacgtggc catccaggcc      420

gtgctgtccc tctacgcctc cggcaggacc accggcatcg tgctggactc cggcgacggc      480

gtcacccaca acgtgcccat ttatgagggc tacgcgctgc cgcacgccat catgcgcctg      540

gacctggcgg gccgcgatct caccgactac ctgatgaaga tcctcactga gcgtggctac      600

tccttcgtga ccacagctga gcgcgagatc gtgcgcgaca tcaaggagaa gctgtgctac      660

gtggccctgg acttcgagaa cgagatggcg acggccgcct cctcctcctc cctggaaaag      720

agctacgagc tgccagacgg gcaggtcatc accatcggca acgagcgctt ccgctgcccg      780

gagacgctct tccagccctc cttcatcggt atggagtcgg cgggcattca cgagaccacc      840

tacaacagca tcatgaagtg tgacatcgac atcaggaagg acctgtatgc caacaacgtc      900

atgtcggggg gcaccacgat gtaccctggg atcgctgacc gcatgcagaa agagatcacc      960

gcgctggcac ccagcaccat gaagatcaag atcatcgccc cgccggagcg caaatactcg     1020

gtgtggatcg gcggctccat cctggcctcg ctgtccacct tccagcagat gtggatcacc     1080

aagcaggagt acgacgaggc cggcccttcc atcgtccacc gcaaatgctt ctag           1134


<210>  638
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Cys Asp Glu Asp Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Met Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Thr Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  639
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  639
atggcactgc agggcatctc ggtcgtggag ctgtccggcc tggccccggg cccgttctgt       60

gctatggtcc tggctgactt cggggcgcgt gtggtacgcg tggaccggcc cggctcccgc      120

tacgacgtga gccgcttggg ccggggcaag cgctcgctag tgctggacct gaagcagccg      180

cggggagccg ccgtgctgcg gcgtctgtgc aagcggtcgg atgtgctgct ggagcccttc      240

cgccgcggtg tcatggagaa actccagctg ggcccagaga ttctgcagcg ggaaaatcca      300

aggcttattt atgccaggct gagtggattt ggccagtcag gaagcttctg ccggttagct      360

ggccacgata tcaactattt ggctttgtca ggtgttctct caaaaattgg cagaagtggt      420

gagaatccgt atgccccgct gaatctcctg gctgactttg ctggtggtgg ccttatgtgt      480

gcactgggca ttataatggc tctttttgac cgcacacgca ctggcaaggg tcaggtcatt      540

gatgcaaata tggtggaagg aacagcatat ttaagttctt ttctgtggaa aactcagaaa      600

tcgagtctgt gggaagcacc tcgaggacag aacatgttgg atggtggagc acctttctat      660

acgacttaca ggacagcaga tggggaattc atggctgttg gagcaataga accccagttc      720

tacgagctgc tgatcaaagg acttggacta aagtctgatg aacttcccaa tcagatgagc      780

atggatgatt ggccagaaat gaagaagaag tttgcagatg tatttgcaaa gaagacgaag      840

gcagagtggt gtcaaatctt tgacggcaca gatgcctgtg tgactccggt tctgactttt      900

gaggaggttg ttcatcatga tcacaacaag gaacggggct cgtttatcac cagtgaggag      960

caggacgtga gcccccgccc tgcacctctg ctgttaaaca ccccagccat cccttctttc     1020

aaaagggatc ctttcatagg agaacacact gaggagatac ttgaagaatt tggattcagc     1080

cgcgaagaga tttatcagct taactcagat aaaatcattg aaagtaataa ggtaaaagct     1140

agtctctaa                                                             1149


<210>  640
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
    130                 135                 140                 


Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                165                 170                 175     


Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
            180                 185                 190         


Ser Phe Leu Trp Lys Thr Gln Lys Ser Ser Leu Trp Glu Ala Pro Arg 
        195                 200                 205             


Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
    210                 215                 220                 


Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
225                 230                 235                 240 


Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                245                 250                 255     


Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
            260                 265                 270         


Asp Val Phe Ala Lys Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
        275                 280                 285             


Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
    290                 295                 300                 


His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
305                 310                 315                 320 


Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                325                 330                 335     


Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
        355                 360                 365             


Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
    370                 375                 380         


<210>  641
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  641
atggcaatgg tatcagaatt cctcaagcag gcctggttta ttgaaaatga agagcaggaa       60

tatgttcaaa ctgtgaagtc atccaaaggt ggtcccggat cagcggtgag cccctatcct      120

accttcaatc catcctcgga tgtcgctgcc ttgcataagg ccataatggt taaaggtgtg      180

gatgaagcaa ccatcattga cattctaact aagcgaaaca atgcacagcg tcaacagatc      240

aaagcagcat atctccagga aacaggaaag cccctggatg aaacactgaa gaaagccctt      300

acaggtcacc ttgaggaggt tgttttagct ctgctaaaaa ctccagcgca atttgatgct      360

gatgaacttc gtgctgccat gaagggcctt ggaactgatg aagatactct aattgagatt      420

ttggcatcaa gaactaacaa agaaatcaga gacattaaca gggtctacag agaggaactg      480

aagagagatc tggccaaaga cataacctca gacacatctg gagattttcg gaacgctttg      540

ctttctcttg ctaagggtga ccgatctgag gactttggtg tgaatgaaga cttggctgat      600

tcagatgcca gggccttgta tgaagcagga gaaaggagaa aggggacaga cgtaaacgtg      660

ttcaatacca tccttaccac cagaagctat ccacaacttc gcagagtgtt tcagaaatac      720

accaagtaca gtaagcatga catgaacaaa gttctggacc tggagttgaa aggtgacatt      780

gagaaatgcc tcacagctat cgtgaagtgc gccacaagca aaccagcttt ctttgcagag      840

aagcttcatc aagccatgaa aggtgttgga actcgccata aggcattgat caggattatg      900

gtttcccgtt ctgaaattga catgaatgat atcaaagcat tctatcagaa gatgtatggt      960

atctcccttt gccaagccat cctggatgaa accaaaggag attatgagaa aatcctggtg     1020

gctctttgtg gaggaaacta a                                               1041


<210>  642
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  643
<211>  1467
<212>  DNA
<213>  Homo sapiens

<400>  643
atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca       60

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca      120

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac      180

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga      240

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca      300

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt      360

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct      420

acttacccta gtcagatcaa tacagattct ttttcttcct atcctgtttt ctctcctgtt      480

tctttggatt atagcagtga acctgccaca gtgactcagg tcactcaagg aactatccga      540

ccagctgcca acttcgatgc tataagagat gcagaaattc ttcgtaaggc aatgaagggt      600

tttgggacag atgagcaggc aattgtggat gtggtggcca accgttccaa tgatcagagg      660

caaaaaatta aagcagcatt taagacctcc tatggcaagg atttaatcaa agatctcaaa      720

tcagagttaa gtggaaatat ggaagaactg atcctggccc tcttcatgcc tcctacgtat      780

tacgatgcct ggagcttacg gaaagcaatg cagggagcag gaactcagga acgtgtattg      840

attgagattt tgtgcacaag aacaaatcag gaaatccgag aaattgtcag atgttatcag      900

tcagaatttg gacgagacct tgaaaaggac attaggtcag atacatcagg acattttgaa      960

cgtttacttg tgtccatgtg ccagggaaat cgtgatgaga accagagtat aaaccaccaa     1020

atggctcagg aagatgctca gcgtctctat caagctggtg aggggagact agggaccgat     1080

gaatcttgct ttaacatgat ccttgccaca agaagctttc ctcagctgag agctaccatg     1140

gaggcttatt ctaggatggc taatcgagac ttgttaagca gtgtgagccg tgagttttcc     1200

ggatatgtag aaagtggttt gaagaccatc ttgcagtgtg ccctgaaccg ccctgccttc     1260

tttgctgaga ggctctacta tgctatgaaa ggtgctggca cagatgactc caccctggtc     1320

cggattgtgg tcactcgaag tgagattgac cttgtacaaa taaaacagat gttcgctcag     1380

atgtatcaga agactctggg cacaatgatt gcaggtgaca cgagtggaga ttaccgaaga     1440

cttcttctgg ctattgtggg ccagtag                                         1467


<210>  644
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Ile Asn Thr Asp Ser Phe Ser Ser Tyr Pro Val Phe Ser Pro Val 
145                 150                 155                 160 


Ser Leu Asp Tyr Ser Ser Glu Pro Ala Thr Val Thr Gln Val Thr Gln 
                165                 170                 175     


Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu 
            180                 185                 190         


Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
        195                 200                 205             


Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys 
    210                 215                 220                 


Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
225                 230                 235                 240 


Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met 
                245                 250                 255     


Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly 
            260                 265                 270         


Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr 
        275                 280                 285             


Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly 
    290                 295                 300                 


Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu 
305                 310                 315                 320 


Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser 
                325                 330                 335     


Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala 
            340                 345                 350         


Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu 
        355                 360                 365             


Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser 
    370                 375                 380                 


Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser 
385                 390                 395                 400 


Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn 
                405                 410                 415     


Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            420                 425                 430         


Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu 
        435                 440                 445             


Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys 
    450                 455                 460                 


Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg 
465                 470                 475                 480 


Leu Leu Leu Ala Ile Val Gly Gln 
                485             


<210>  645
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  645
atgccggctt accactcttc tctcatggat cctgatacca aactcatcgg aaacatggca       60

ctgttgccta tcagaagtca attcaaagga cctgccccca gagagacaaa agatacagat      120

attgtggatg aagccatcta ttacttcaag gccaatgtct tcttcaaaaa ctatgaaatt      180

aagaatgaag ctgataggac cttgatatat ataactctct acatttctga atgtctgaag      240

aaactgcaaa agtgcaattc caaaagccaa ggtgagaaag aaatgtatac gctgggaatc      300

actaattttc ccattcctgg agagcctggt tttccactta acgcaattta tgccaaacct      360

gcaaacaaac aggaagatga agtgatgaga gcctatttac aacagctaag gcaagagact      420

ggactgagac tttgtgagaa agttttcgac cctcagaatg ataaacccag caagtggtgg      480

acttgctttg tgaagagaca gttcatgaac aagagtcttt caggacctgg acagtga         537


<210>  646
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Thr Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Thr Lys Asp Thr Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Thr Leu Ile Tyr Ile Thr Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Thr Leu Gly Ile Thr Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Thr Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Phe Asp Pro Gln Asn Asp Lys Pro Ser Lys Trp Trp 
145                 150                 155                 160 


Thr Cys Phe Val Lys Arg Gln Phe Met Asn Lys Ser Leu Ser Gly Pro 
                165                 170                 175     


Gly Gln 
        


<210>  647
<211>  1188
<212>  DNA
<213>  Homo sapiens

<400>  647
atgccgggcc ggagttgcgt cgccttagtc ctcctggctg ccgccgtcag ctgtgccgtc       60

gcgcagcacg cgccgccgtg gacagaggac tgcagaaaat caacctatcc tccttcagga      120

ccaacgtaca gaggtgcagt tccatggtac accataaatc ttgacttacc accctacaaa      180

agatggcatg aattgatgct tgacaaggca ccaatgctaa aggttatagt gaattctctg      240

aagaatatga taaatacatt cgtgccaagt ggaaaagtta tgcaggtggt ggatgaaaaa      300

ttgcctggcc tacttggcaa ctttcctggc ccttttgaag aggaaatgaa gggtattgcc      360

gctgttactg atataccttt aggagagatt atttcattca atatttttta tgaattattt      420

accatttgta cttcaatagt agcagaagac aaaaaaggtc atctaataca tgggagaaac      480

atggattttg gagtatttct tgggtggaac ataaataatg atacctgggt cataactgag      540

caactaaaac ctttaacagt gaatttggat ttccaaagaa acaacaaaac tgtcttcaag      600

gcttcaagct ttgctggcta tgtgggcatg ttaacaggat tcaaaccagg actgttcagt      660

cttacactga atgaacgttt cagtataaat ggtggttatc tgggtattct agaatggatt      720

ctgggaaaga aagatgccat gtggataggg ttcctcacta gaacagttct ggaaaatagc      780

acaagttatg aagaagccaa gaatttattg accaagacca agatattggc cccagcctac      840

tttatcctgg gaggcaacca gtctggggaa ggttgtgtga ttacacgaga cagaaaggaa      900

tcattggatg tatatgaact cgatgctaag cagggtagat ggtatgtggt acaaacaaat      960

tatgaccgtt ggaaacatcc cttcttcctt gatgatcgca gaacgcctgc aaagatgtgt     1020

ctgaaccgca ccagccaaga gaatatctca tttgaaacca tgtatgatgt cctgtcaaca     1080

aaacctgtcc tcaacaagct gaccgtatac acaaccttga tagatgttac caaaggtcaa     1140

ttcgaaactt acctgcggga ctgccctgac ccttgtatag gttggtga                  1188


<210>  648
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Met Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Val Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Ala Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  649
<211>  1035
<212>  DNA
<213>  Homo sapiens

<400>  649
atggcccaga aggagaactc ctacccctgg ccctacggcc gacagacggc tccatctggc       60

ctgagcaccc tgccccagcg agtcctccgg aaagagcctg tcaccccatc tgcacttgtc      120

ctcatgagcc gctccaatgt ccagcccaca gctgcccctg gccagaaggt gatggagaat      180

agcagtggga cacccgacat cttaacgcgg cacttcacaa ttgatgactt tgagattggg      240

cgtcctctgg gcaaaggcaa gtttggaaac gtgtacttgg ctcgggagaa gaaaagccat      300

ttcatcgtgg cgctcaaggt cctcttcaag tcccagatag agaaggaggg cgtggagcat      360

cagctgcgca gagagatcga aatccaggcc cacctgcacc atcccaacat cctgcgtctc      420

tacaactatt tttatgaccg gaggaggatc tacttgattc tagagtatgc cccccgcggg      480

gagctctaca aggagctgca gaagagctgc acatttgacg agcagcgaac agccacgatc      540

atggaggagt tggcagatgc tctaatgtac tgccatggga agaaggtgat tcacagagac      600

ataaagccag aaaatctgct cttagggctc aagggagagc tgaagattgc tgacttcggc      660

tggtctgtgc atgcgccctc cctgaggagg aagacaatgt gtggcaccct ggactacctg      720

cccccagaga tgattgaggg gcgcatgcac aatgagaagg tggatctgtg gtgcattgga      780

gtgctttgct atgagctgct ggtggggaac ccaccctttg agagtgcatc acacaacgag      840

acctatcgcc gcatcgtcaa ggtggaccta aagttccccg cttccgtgcc catgggagcc      900

caggacctca tctccaaact gctcaggcat aacccctcgg aacggctgcc cctggcccag      960

gtctcagccc acccttgggt ccgggccaac tctcggaggg tgctgcctcc ctctgccctt     1020

caatctgtcg cctga                                                      1035


<210>  650
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210>  651
<211>  1857
<212>  DNA
<213>  Homo sapiens

<400>  651
atgcacaaaa ctgcctccca aagacttttc ccaggtccct cgtatcaaaa cattaagagt       60

ataatggaag atagcacgat cttgtcagat tggacaaaca gcaacaaaca aaaaatgaag      120

tatgactttt cctgtgaact ctacagaatg tctacatatt caactttccc cgccggggtg      180

cctgtctcag aaaggagtct tgctcgtgct ggtttttatt atactggtgt gaatgacaag      240

gtcaaatgct tctgttgtgg cctgatgctg gataactgga aactaggaga cagtcctatt      300

caaaagcata aacagctata tcctagctgt agctttattc agaatctggt ttcagctagt      360

ctgggatcca cctctaagaa tacgtctcca atgagaaaca gttttgcaca ttcattatct      420

cccaccttgg aacatagtag cttgttcagt ggttcttact ccagcctttc tccaaaccct      480

cttaattcta gagcagttga agacatctct tcatcgagga ctaaccccta cagttatgca      540

atgagtactg aagaagccag atttcttacc taccatatgt ggccattaac ttttttgtca      600

ccatcagaat tggcaagagc tggtttttat tatataggac ctggagatag ggtagcctgc      660

tttgcctgtg gtgggaagct cagtaactgg gaaccaaagg atgatgctat gtcagaacac      720

cggaggcatt ttcccaactg tccatttttg gaaaattctc tagaaactct gaggtttagc      780

atttcaaatc tgagcatgca gacacatgca gctcgaatga gaacatttat gtactggcca      840

tctagtgttc cagttcagcc tgagcagctt gcaagtgctg gtttttatta tgtgggtcgc      900

aatgatgatg tcaaatgctt ttgttgtgat ggtggcttga ggtgttggga atctggagat      960

gatccatggg tagaacatgc caagtggttt ccaaggtgtg agttcttgat acgaatgaaa     1020

ggccaagagt ttgttgatga gattcaaggt agatatcctc atcttcttga acagctgttg     1080

tcaacttcag ataccactgg agaagaaaat gctgacccac caattattca ttttggacct     1140

ggagaaagtt cttcagaaga tgctgtcatg atgaatacac ctgtggttaa atctgccttg     1200

gaaatgggct ttaatagaga cctggtgaaa caaacagttc aaagtaaaat cctgacaact     1260

ggagagaact ataaaacagt taatgatatt gtgtcagcac ttcttaatgc tgaagatgaa     1320

aaaagagaag aggagaagga aaaacaagct gaagaaatgg catcagatga tttgtcatta     1380

attcggaaga acagaatggc tctctttcaa caattgacat gtgtgcttcc tatcctggat     1440

aatcttttaa aggccaatgt aattaataaa caggaacatg atattattaa acaaaaaaca     1500

cagatacctt tacaagcgag agaactgatt gataccattt tggttaaagg aaatgctgcg     1560

gccaacatct tcaaaaactg tctaaaagaa attgactcta cattgtataa gaacttattt     1620

gtggataaga atatgaagta tattccaaca gaagatgttt caggtctgtc actggaagaa     1680

caattgagga ggttgcaaga agaacgaact tgtaaagtgt gtatggacaa agaagtttct     1740

gttgtattta ttccttgtgg tcatctggta gtatgccagg aatgtgcccc ttctctaaga     1800

aaatgcccta tttgcagggg tataatcaag ggtactgttc gtacatttct ctcttaa        1857


<210>  652
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  652

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  653
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  653
atggaaggag acttctcggt gtgcaggaac tgtaaaagac atgtagtctc tgccaacttc       60

accctccatg aggcttactg cctgcggttc ctggtcctgt gtccggagtg tgaggagcct      120

gtccccaagg aaaccatgga ggagcactgc aagcttgagc accagcaggt tgggtgtacg      180

atgtgtcagc agagcatgca gaagtcctcg ctggagtttc ataaggccaa tgagtgccag      240

gagcgccctg ttgagtgtaa gttctgcaaa ctggacatgc agctcagcaa gctggagctc      300

cacgagtcct actgtggcag ccggacagag ctctgccaag gctgtggcca gttcatcatg      360

caccgcatgc tcgcccagca cagagatgtc tgtcgcagtg aacaggccca gctcgggaaa      420

ggggaaagaa tttcagctcc tgaaagggaa atctactgtc attattgcaa ccaaatgatt      480

ccagaaaata agtatttcca ccatatgggt aaatgttgtc cagactcaga gtttaagaaa      540

cactttcctg ttggaaatcc agaaattctt ccttcatctc ttccaagtca agctgctgaa      600

aatcaaactt ccacgatgga gaaagatgtt cgtccaaaga caagaagtat aaacagattt      660

cctcttcatt ctgaaagttc atcaaagaaa gcaccaagaa gcaaaaacaa aaccttggat      720

ccacttttga tgtcagagcc caagcccagg accagctccc ctagaggaga taaagcagcc      780

tatgacattc tgaggagatg ttctcagtgt ggcatcctgc ttcccctgcc gatcctaaat      840

caacatcagg agaaatgccg gtggttagct tcatcaaaag gaaaacaagt gagaaatttc      900

agctag                                                                 906


<210>  654
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Val Gly Cys Thr Met Cys Gln Gln 
    50                  55                  60                  


Ser Met Gln Lys Ser Ser Leu Glu Phe His Lys Ala Asn Glu Cys Gln 
65                  70                  75                  80  


Glu Arg Pro Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser 
                85                  90                  95      


Lys Leu Glu Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys 
            100                 105                 110         


Gln Gly Cys Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg 
        115                 120                 125             


Asp Val Cys Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile 
    130                 135                 140                 


Ser Ala Pro Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile 
145                 150                 155                 160 


Pro Glu Asn Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser 
                165                 170                 175     


Glu Phe Lys Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser 
            180                 185                 190         


Ser Leu Pro Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys 
        195                 200                 205             


Asp Val Arg Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser 
    210                 215                 220                 


Glu Ser Ser Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp 
225                 230                 235                 240 


Pro Leu Leu Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly 
                245                 250                 255     


Asp Lys Ala Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile 
            260                 265                 270         


Leu Leu Pro Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp 
        275                 280                 285             


Leu Ala Ser Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
    290                 295                 300     


<210>  655
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  655
atgcctcctc agcttcaaga aactagaatg aaccgaagca ttcctgtgga ggttgatgaa       60

tcagaaccat acccaagtca gttgctgaaa ccaatcccag aatattcccc ggaagaggaa      120

tcagaaccac ctgctccaaa tataaggaac atggcaccca acagcttgtc tgcacccaca      180

atgcttcaca attcctccgg agacttttct caagctcact caaccctgaa acttgcaaat      240

caccagcggc ctgtatcccg gcaggtcacc tgcctgcgca ctcaagttct ggaggacagt      300

gaagacagtt tctgcaggag acacccaggc ctgggcaaag ctttcccttc tgggtgctct      360

gcagtcagcg agcctgcgtc tgagtctgtg gttggagccc tccctgcaga gcatcagttt      420

tcatttatgg aaaaacgtaa tcaatggctg gtatctcagc tttcagcggc ttctcctgac      480

actggccatg actcagacaa atcagaccaa agtttaccta atgcctcagc agactccttg      540

ggcggtagcc aggagatggt gcaacggccc cagcctcaca ggaaccgagc aggcctggat      600

ctgccaacca tagacacggg atatgattcc cagccccagg atgtcctggg catcaggcag      660

ctggaaaggc ccctgcccct cacctccgtg tgttaccccc aggacctccc cagacctctc      720

aggtccaggg agttccctca gtttgaacct cagaggtatc cagcatgtgc acagatgctg      780

cctcccaatc tttccccaca tgctccatgg aactatcatt accattgtcc tggaagtccc      840

gatcaccagg tgccatatgg ccatgactac cctcgagcag cctaccagca agtgatccag      900

ccggctctgc ctgggcagcc cctgcctgga gccagtgtga gaggcctgca ccctgtgcag      960

aaggttatcc tgaattatcc cagcccctgg gaccacgaag agaggcccgc acagagagac     1020

tgctcctttc cggggcttcc aaggcaccag gaccagccac atcaccagcc acctaataga     1080

gctggtgctc ctggggagtc cttggagtgc cctgcagagc tgagaccaca ggttccccag     1140

cctccgtccc cagctgctgt gcctagaccc cctagcaacc ctccagccag aggaactcta     1200

aaaacaagca atttgccaga agaattgcgg aaagtcttta tcacttattc gatggacaca     1260

gctatggagg tggtgaaatt cgtgaacttt ttgttggtaa atggcttcca aactgcaatt     1320

gacatatttg aggatagaat ccgaggcatt gatatcatta aatggatgga gcgctacctt     1380

agggataaga ccgtgatgat aatcgtagca atcagcccca aatacaaaca ggacgtggaa     1440

ggcgctgagt cgcagctgga cgaggatgag catggcttac atactaagta cattcatcga     1500

atgatgcaga ttgagttcat aaaacaagga agcatgaatt tcagattcat ccctgtgctc     1560

ttcccaaatg ctaagaagga gcatgtgccc acctggcttc agaacactca tgtctacagc     1620

tggcccaaga ataaaaaaaa catcctgctg cggctgctga gagaggaaga gtatgtggct     1680

cctccacggg ggcctctgcc cacccttcag gtggttccct tgtga                     1725


<210>  656
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Pro Pro Gln Leu Gln Glu Thr Arg Met Asn Arg Ser Ile Pro Val 
1               5                   10                  15      


Glu Val Asp Glu Ser Glu Pro Tyr Pro Ser Gln Leu Leu Lys Pro Ile 
            20                  25                  30          


Pro Glu Tyr Ser Pro Glu Glu Glu Ser Glu Pro Pro Ala Pro Asn Ile 
        35                  40                  45              


Arg Asn Met Ala Pro Asn Ser Leu Ser Ala Pro Thr Met Leu His Asn 
    50                  55                  60                  


Ser Ser Gly Asp Phe Ser Gln Ala His Ser Thr Leu Lys Leu Ala Asn 
65                  70                  75                  80  


His Gln Arg Pro Val Ser Arg Gln Val Thr Cys Leu Arg Thr Gln Val 
                85                  90                  95      


Leu Glu Asp Ser Glu Asp Ser Phe Cys Arg Arg His Pro Gly Leu Gly 
            100                 105                 110         


Lys Ala Phe Pro Ser Gly Cys Ser Ala Val Ser Glu Pro Ala Ser Glu 
        115                 120                 125             


Ser Val Val Gly Ala Leu Pro Ala Glu His Gln Phe Ser Phe Met Glu 
    130                 135                 140                 


Lys Arg Asn Gln Trp Leu Val Ser Gln Leu Ser Ala Ala Ser Pro Asp 
145                 150                 155                 160 


Thr Gly His Asp Ser Asp Lys Ser Asp Gln Ser Leu Pro Asn Ala Ser 
                165                 170                 175     


Ala Asp Ser Leu Gly Gly Ser Gln Glu Met Val Gln Arg Pro Gln Pro 
            180                 185                 190         


His Arg Asn Arg Ala Gly Leu Asp Leu Pro Thr Ile Asp Thr Gly Tyr 
        195                 200                 205             


Asp Ser Gln Pro Gln Asp Val Leu Gly Ile Arg Gln Leu Glu Arg Pro 
    210                 215                 220                 


Leu Pro Leu Thr Ser Val Cys Tyr Pro Gln Asp Leu Pro Arg Pro Leu 
225                 230                 235                 240 


Arg Ser Arg Glu Phe Pro Gln Phe Glu Pro Gln Arg Tyr Pro Ala Cys 
                245                 250                 255     


Ala Gln Met Leu Pro Pro Asn Leu Ser Pro His Ala Pro Trp Asn Tyr 
            260                 265                 270         


His Tyr His Cys Pro Gly Ser Pro Asp His Gln Val Pro Tyr Gly His 
        275                 280                 285             


Asp Tyr Pro Arg Ala Ala Tyr Gln Gln Val Ile Gln Pro Ala Leu Pro 
    290                 295                 300                 


Gly Gln Pro Leu Pro Gly Ala Ser Val Arg Gly Leu His Pro Val Gln 
305                 310                 315                 320 


Lys Val Ile Leu Asn Tyr Pro Ser Pro Trp Asp His Glu Glu Arg Pro 
                325                 330                 335     


Ala Gln Arg Asp Cys Ser Phe Pro Gly Leu Pro Arg His Gln Asp Gln 
            340                 345                 350         


Pro His His Gln Pro Pro Asn Arg Ala Gly Ala Pro Gly Glu Ser Leu 
        355                 360                 365             


Glu Cys Pro Ala Glu Leu Arg Pro Gln Val Pro Gln Pro Pro Ser Pro 
    370                 375                 380                 


Ala Ala Val Pro Arg Pro Pro Ser Asn Pro Pro Ala Arg Gly Thr Leu 
385                 390                 395                 400 


Lys Thr Ser Asn Leu Pro Glu Glu Leu Arg Lys Val Phe Ile Thr Tyr 
                405                 410                 415     


Ser Met Asp Thr Ala Met Glu Val Val Lys Phe Val Asn Phe Leu Leu 
            420                 425                 430         


Val Asn Gly Phe Gln Thr Ala Ile Asp Ile Phe Glu Asp Arg Ile Arg 
        435                 440                 445             


Gly Ile Asp Ile Ile Lys Trp Met Glu Arg Tyr Leu Arg Asp Lys Thr 
    450                 455                 460                 


Val Met Ile Ile Val Ala Ile Ser Pro Lys Tyr Lys Gln Asp Val Glu 
465                 470                 475                 480 


Gly Ala Glu Ser Gln Leu Asp Glu Asp Glu His Gly Leu His Thr Lys 
                485                 490                 495     


Tyr Ile His Arg Met Met Gln Ile Glu Phe Ile Lys Gln Gly Ser Met 
            500                 505                 510         


Asn Phe Arg Phe Ile Pro Val Leu Phe Pro Asn Ala Lys Lys Glu His 
        515                 520                 525             


Val Pro Thr Trp Leu Gln Asn Thr His Val Tyr Ser Trp Pro Lys Asn 
    530                 535                 540                 


Lys Lys Asn Ile Leu Leu Arg Leu Leu Arg Glu Glu Glu Tyr Val Ala 
545                 550                 555                 560 


Pro Pro Arg Gly Pro Leu Pro Thr Leu Gln Val Val Pro Leu 
                565                 570                 


<210>  657
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  657
atggatgatt ttgagcgtcg cagagaactt agaaggcaaa agagggagga gatgcgactc       60

gaagcagaaa gaatcgccta ccagaggaat gacgatgatg aagaggaggc agcccgggaa      120

cgccgccgcc gagcccgaca ggaacggctg cggcagaagc aggaggaaga atccttggga      180

caggtgaccg accaggtgga ggtgaatgcc cagaacagtg tgcctgacga ggaggccaag      240

acaaccacca caaacactca agtggaaggg gatgatgagg ccgcattcct ggagcgcctg      300

gctcggcgtg aggaaagacg ccaaaaacgc cttcaggagg ctctggagcg gcagaaggag      360

ttcgacccaa caataacaga tgcaagtctg tcgctcccaa gcagaagaat gcaaaatgac      420

acagcagaaa atgaaactac cgagaaggaa gaaaaaagtg aaagtcgcca agaaagatac      480

gagatagagg aaacagaaac agtcaccaag tcctaccaga agaatgattg gagggatgct      540

gaagaaaaca agaaagaaga caaggaaaag gaggaggagg aagaggagaa gccaaagcga      600

gggagcattg gagaaaatca ggtagaggtg atggtggaag agaaaacaac tgaaagccag      660

gaggaaacag tggtaatgtc attaaaaaat gggcagatca gttcagaaga gcctaaacaa      720

gaggaggaga gggaacaagg ttcagatgag atttcccatc atgaaaagat ggaagaggaa      780

gacaaggaaa gagctgaggc agagagggca aggttggaag cagaagaaag agaaagaatt      840

aaagccgagc aagacaaaaa gatagcagat gaacgagcaa gaattgaagc agaagaaaaa      900

gcagctgccc aagaaagaga aaggagagag gcagaagaga gggaaaggat gagggaggaa      960

gagaaaaggg cagcagagga gaggcagagg ataaaggagg aagagaaaag ggcagcagag     1020

gagaggcaga ggataaagga ggaagagaaa agggcagcag aggagaggca gaggataaaa     1080

gaggaagaga aaagggcagc agaggagagg caaagggcca gggcagagga ggaagagaag     1140

gctaaggtag aagagcagaa acgtaacaag cagctagaag agaaaaaacg tgccatgcaa     1200

gagacaaaga taaaagggga aaaggtagaa cagaaaatag aagggaaatg ggtaaatgaa     1260

aagaaagcac aagaagataa acttcagaca gctgtcctaa agaaacaggg agaagagaag     1320

ggaactaaag tgcaagctaa aagagaaaag ctccaagaag acaagcctac cttcaaaaaa     1380

gaagagatca aagatgaaaa gattaaaaag gacaaagaac ccaaagaaga agttaagagc     1440

ttcatggatc gaaagaaggg atttacagaa gttaagtcgc agaatggaga attcatgacc     1500

cacaaactta aacatactga gaatactttc agccgccctg gagggagggc cagcgtggac     1560

accaaggagg ctgagggcgc cccccaggtg gaagccggca aaaggctgga ggagcttcgt     1620

cgtcgtcgcg gggagaccga gagcgaagag ttcgagaagc tcaaacagaa gcagcaggag     1680

gcggctttgg agctggagga actcaagaaa aagagggagg agagaaggaa ggtcctggag     1740

gaggaagagc agaggaggaa gcaggaggaa gccgatcgaa aactcagaga ggaggaagag     1800

aagaggaggc taaaggaaga gattgaaagg cgaagagcag aagctgctga gaaacgccag     1860

aagatgccag aagatggctt gtcagatgac aagaaaccat tcaagtgttt cactcctaaa     1920

ggttcatctc tcaagataga agagcgagca gaatttttga ataagtctgt gcagaaaagc     1980

agtggtgtca aatcgaccca tcaagcagca atagtctcca agattgacag cagactggag     2040

cagtatacca gtgcaattga gggaacaaaa agcgcaaaac ctacaaagcc ggcagcctcg     2100

gatcttcctg ttcctgctga aggtgtacgc aacatcaaga gtatgtggga gaaagggaat     2160

gtgttttcat cccccactgc agcaggcaca ccaaataagg aaactgctgg cttgaaggta     2220

ggggtttcta gccgcatcaa tgaatggcta actaaaaccc cagatggaaa caagtcacct     2280

gctcccaaac cttctgactt gagaccagga gacgtatcca gcaagcggaa cctctgggaa     2340

aagcaatctg tggataaggt cacttccccc actaaggttt ga                        2382


<210>  658
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
        195                 200                 205             


Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
    210                 215                 220                 


Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
225                 230                 235                 240 


Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                245                 250                 255     


Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
            260                 265                 270         


Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
        275                 280                 285             


Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
    290                 295                 300                 


Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
305                 310                 315                 320 


Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                325                 330                 335     


Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
            340                 345                 350         


Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
        355                 360                 365             


Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
    370                 375                 380                 


Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
385                 390                 395                 400 


Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                405                 410                 415     


Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
            420                 425                 430         


Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
        435                 440                 445             


Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
    450                 455                 460                 


Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
465                 470                 475                 480 


Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                485                 490                 495     


Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
            500                 505                 510         


Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
        515                 520                 525             


Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
    530                 535                 540                 


Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
545                 550                 555                 560 


Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
            580                 585                 590         


Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
        595                 600                 605             


Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
    610                 615                 620                 


Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
625                 630                 635                 640 


Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                645                 650                 655     


Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
            660                 665                 670         


Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
        675                 680                 685             


Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
    690                 695                 700                 


Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
705                 710                 715                 720 


Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                725                 730                 735     


Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
            740                 745                 750         


Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
        755                 760                 765             


Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
    770                 775                 780                 


Asp Lys Val Thr Ser Pro Thr Lys Val 
785                 790             


<210>  659
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  659
atggccacca ccgccacctg cacccgtttc accgacgact accagctctt cgaggagctt       60

ggcaagggtg ctttctctgt ggtccgcagg tgtgtgaaga aaacctccac gcaggagtac      120

gcagcaaaaa tcatcaatac caagaagttg tctgcccggg atcaccagaa actagaacgt      180

gaggctcgga tatgtcgact tctgaaacat ccaaacatcg tgcgcctcca tgacagtatt      240

tctgaagaag ggtttcacta cctcgtgttt gaccttgtta ccggcgggga gctgtttgaa      300

gacattgtgg ccagagagta ctacagtgaa gcagatgcca gccactgtat acatcagatt      360

ctggagagtg ttaaccacat ccaccagcat gacatcgtcc acagggacct gaagcctgag      420

aacctgctgc tggcgagtaa atgcaagggt gccgccgtca agctggctga ttttggccta      480

gccatcgaag tacagggaga gcagcaggct tggtttggtt ttgctggcac cccaggttac      540

ttgtcccctg aggtcttgag gaaagatccc tatggaaaac ctgtggatat ctgggcctgc      600

ggggtcatcc tgtatatcct cctggtgggc tatcctccct tctgggatga ggatcagcac      660

aagctgtatc agcagatcaa ggctggagcc tatgatttcc catcaccaga atgggacacg      720

gtaactcctg aagccaagaa cttgatcaac cagatgctga ccataaaccc agcaaagcgc      780

atcacggctg accaggctct caagcacccg tgggtctgtc aacgatccac ggtggcatcc      840

atgatgcatc gtcaggagac tgtggagtgt ttgcgcaagt tcaatgcccg gagaaaactg      900

aagggtgcca tcctcacgac catgcttgtc tccaggaact tctcagttgg caggcagagc      960

tccgcccccg cctcgcctgc cgcgagcgcc gccggcctgg ccgggcaagc tgccaaaagc     1020

ctattgaaca agaagtcgga tggcggtgtc aagaaaagga agtcgagttc cagcgtgcac     1080

ctaatggagc cacaaaccac tgtggtacac aacgctacag atgggatcaa gggctccaca     1140

gagagctgca acaccaccac agaagatgag gacctcaaag tgcgaaaaca ggagatcatt     1200

aagattacag aacagctgat tgaagccatc aacaatgggg actttgaggc ctacacgaag     1260

atttgtgatc caggcctcac ttcctttgag cctgaggccc ttggtaacct cgtggagggg     1320

atggatttcc ataagtttta ctttgagaat ctcctgtcca agaacagcaa gcctatccat     1380

accaccatcc taaacccaca cgtccacgtg attggggagg acgcagcgtg catcgcctac     1440

atccgcctca cccagtacat cgacgggcag ggtcggcctc gcaccagcca gtcagaagag     1500

acccgggtct ggcaccgtcg ggatggcaag tggctcaatg tccactatca ctgctcaggg     1560

gcccctgccg caccgctgca gtga                                            1584


<210>  660
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
305                 310                 315                 320 


Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                325                 330                 335     


Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
            340                 345                 350         


Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Thr Thr Val 
        355                 360                 365             


Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
    370                 375                 380                 


Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
385                 390                 395                 400 


Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                405                 410                 415     


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
            420                 425                 430         


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
        435                 440                 445             


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
    450                 455                 460                 


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
465                 470                 475                 480 


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
                485                 490                 495     


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
            500                 505                 510         


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
        515                 520                 525         


<210>  661
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  661
atggcagatg atcagggctg tattgaagag cagggggttg aggattcagc aaatgaagat       60

tcagtggatg ctaagccaga ccggtcctcg tttgtaccgt ccctcttcag taagaagaag      120

aaaaatgtca ccatgcgatc catcaagacc acccgggacc gagtgcctac atatcagtac      180

aacatgaatt ttgaaaagct gggcaaatgc atcataataa acaacaagaa ctttgataaa      240

gtgacaggta tgggcgttcg aaacggaaca gacaaagatg ccgaggcgct cttcaagtgc      300

ttccgaagcc tgggttttga cgtgattgtc tataatgact gctcttgtgc caagatgcaa      360

gatctgctta aaaaagcttc tgaagaggac catacaaatg ccgcctgctt cgcctgcatc      420

ctcttaagcc atggagaaga aaatgtaatt tatgggaaag atggtgtcac accaataaag      480

gatttgacag cccactttag gggggataga tgcaaaaccc ttttagagaa acccaaactc      540

ttcttcattc aggcttgccg agggaccgag cttgatgatg gcatccaggc cgactcgggg      600

cccatcaatg acacagatgc taatcctcga tacaagatcc cagtggaagc tgacttcctc      660

ttcgcctatt ccacggttcc aggctattac tcgtggagga gcccaggaag aggctcctgg      720

tttgtgcaag ccctctgctc catcctggag gagcacggaa aagacctgga aatcatgcag      780

atcctcacca gggtgaatga cagagttgcc aggcactttg agtctcagtc tgatgaccca      840

cacttccatg agaagaagca gatcccctgt gtggtctcca tgctcaccaa ggaactctac      900

ttcagtcaat ag                                                          912


<210>  662
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  663
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  663
atgtctgggg gcaaatacgt agactcggag ggacatctct acaccgttcc catccgggaa       60

cagggcaaca tctacaagcc caacaacaag gccatggcag acgagctgag cgagaagcaa      120

gtgtacgacg cgcacaccaa ggagatcgac ctggtcaacc gcgaccctaa acacctcaac      180

gatgacgtgg tcaagattga ctttgaagat gtgattgcag aaccagaagg gacacacagt      240

tttgacggca tttggaaggc cagcttcacc accttcactg tgacgaaata ctggttttac      300

cgcttgctgt ctgccctctt tggcatcccg atggcactca tctggggcat ttacttcgcc      360

attctctctt tcctgcacat ctgggcagtt gtaccatgca ttaagagctt cctgattgag      420

attcagtgca tcagccgtgt ctattccatc tacgtccaca ccgtctgtga cccactcttt      480

gaagctgttg ggaaaatatt cagcaatgtc cgcatcaact tgcagaaaga aatataa         537


<210>  664
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  665
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  665
atggggctgg agacggagaa ggcggacgta cagctcttca tggacgacga ctcctacagc       60

caccacagcg gcctcgagta cgccgacccc gagaagttcg cggactcgga ccaggaccgg      120

gatccccacc ggctcaactc gcatctcaag ctgggcttcg aggatgtgat cgcagagccg      180

gtgactacgc actcctttga caaagtgtgg atctgcagcc atgccctctt tgaaatcagc      240

aaatacgtaa tgtacaagtt cctgacggtg ttcctggcca ttcccctggc cttcattgcg      300

ggaattctct ttgccaccct cagctgtctg cacatctgga ttttaatgcc ttttgtaaag      360

acctgcctaa tggttctgcc ttcagtgcag acaatatgga agagtgtgac agatgttatc      420

attgctccat tgtgtacgag cgtaggacga tgcttctctt ctgtcagcct gcaactgagc      480

caggattga                                                              489


<210>  666
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210>  667
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  667
atggcctcca acaaaactac attgcaaaaa atgggaaaaa aacagaatgg aaagagtaaa       60

aaagttgaag aggcagagcc tgaagaattt gtcgtggaaa aagtactaga tcgacgtgta      120

gtgaatggga aagtggaata tttcctgaag tggaagggat ttacagatgc tgacaatact      180

tgggaacctg aagaaaattt agattgtcca gaattgattg aagcgtttct taactctcag      240

aaagctggca aagaaaaaga tggtacaaaa agaaaatctt tatctgacag tgaatctgat      300

gacagcaaat caaagaagaa aagagatgct gctgacaaac caagaggatt tgccagaggt      360

cttgatcctg aaagaataat tggtgccaca gacagcagtg gagaattgat gtttctcatg      420

aaatggaaag attcagatga ggcagacttg gtgctggcga aagaggcaaa tatgaagtgt      480

cctcaaattg taattgcttt ttatgaagag agactaactt ggcattcttg tccagaagat      540

gaagctcaat aa                                                          552


<210>  668
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  669
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  669
atgcagacaa ttaagtgtgt tgttgtgggc gatggtgctg ttggtaaaac atgtctcctg       60

atatcctaca caacaaacaa atttccatcg gaatatgtac cgactgtttt tgacaactat      120

gcagtcacag ttatgattgg tggagaacca tatactcttg gactttttga tactgcaggg      180

caagaggatt atgacagatt acgaccgctg agttatccac aaacagatgt atttctagtc      240

tgtttttcag tggtctctcc atcttcattt gaaaacgtga aagaaaagtg ggtgcctgag      300

ataactcacc actgtccaaa gactcctttc ttgcttgttg ggactcaaat tgatctcaga      360

gatgacccct ctactattga gaaacttgcc aagaacaaac agaagcctat cactccagag      420

actgctgaaa agctggcccg tgacctgaag gctgtcaagt atgtggagtg ttctgcactt      480

acacagagag gtctgaagaa tgtgtttgat gaggctatcc tagctgccct cgagcctccg      540

gaaactcaac ccaaaaggaa gtgctgtata ttctaa                                576


<210>  670
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
            180                 185                 190     


<210>  671
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  671
atggagaact tccaaaaggt ggaaaagatc ggagagggca cgtacggagt tgtgtacaaa       60

gccagaaaca agttgacggg agaggtggtg gcgcttaaga aaatccgcct ggacactgag      120

actgagggtg tgcccagtac tgccatccga gagatctctc tgcttaagga gcttaaccat      180

cctaatattg tcaagctgct ggatgtcatt cacacagaaa ataaactcta cctggttttt      240

gaatttctgc accaagatct caagaaattc atggatgcct ctgctctcac tggcattcct      300

cttcccctca tcaagagcta tctgttccag ctgctccagg gcctagcttt ctgccattct      360

catcgggtcc tccaccgaga ccttaaacct cagaatctgc ttattaacac agagggggcc      420

atcaagctag cagactttgg actagccaga gcttttggag tccctgttcg tacttacacc      480

catgaggtgg tgaccctgtg gtaccgagct cctgaaatcc tcctgggctg caaatattat      540

tccacagctg tggacatctg gagcctgggc tgcatctttg ctgagatggt gactcgccgg      600

gccctattcc ctggagattc tgagattgac cagctcttcc ggatctttcg gactctgggg      660

accccagatg aggtggtgtg gccaggagtt acttctatgc ctgattacaa gccaagtttc      720

cccaagtggg cccggcaaga ttttagtaaa gttgtacctc ccctggatga agatggacgg      780

agcttgttat cgcaaatgct gcactacgac cctaacaagc ggatttcggc caaggcagcc      840

ctggctcacc ctttcttcca ggatgtgacc aagccagtac cccatcttcg actctga         897


<210>  672
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 
    210                 215                 220                 


Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
                245                 250                 255     


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
            260                 265                 270         


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
        275                 280                 285             


Val Thr Lys Pro Val Pro His Leu Arg Leu 
    290                 295             


<210>  673
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  673
atggctacct ctcgatatga gccagtggct gaaattggtg tcggtgccta tgggacagtg       60

tacaaggccc gtgatcccca cagtggccac tttgtggccc tcaagagtgt gagagtcccc      120

aatggaggag gaggtggagg aggccttccc atcagcacag ttcgtgaggt ggctttactg      180

aggcgactgg aggcttttga gcatcccaat gttgtccggc tgatggacgt ctgtgccaca      240

tcccgaactg accgggagat caaggtaacc ctggtgtttg agcatgtaga ccaggaccta      300

aggacatatc tggacaaggc acccccacca ggcttgccag ccgaaacgat caaggatctg      360

atgcgccagt ttctaagagg cctagatttc cttcatgcca attgcatcgt tcaccgagat      420

ctgaagccag agaacattct ggtgacaagt ggtggaacag tcaagctggc tgactttggc      480

ctggccagaa tctacagcta ccagatggca cttacacccg tggttgttac actctggtac      540

cgagctcccg aagttcttct gcagtccaca tatgcaacac ctgtggacat gtggagtgtt      600

ggctgtatct ttgcagagat gtttcgtcga aagcctctct tctgtggaaa ctctgaagcc      660

gaccagttgg gcaaaatctt tgacctgatt gggctgcctc cagaggatga ctggcctcga      720

gatgtatccc tgccccgtgg agcctttccc cccagagggc cccgcccagt gcagtcggtg      780

gtacctgaga tggaggagtc gggagcacag ctgctgctgg aaatgctgac ttttaaccca      840

cacaagcgaa tctctgcctt tcgagctctg cagcactctt atctacataa ggatgaaggt      900

aatccggagt ga                                                          912


<210>  674
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  675
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  675
atggctctgg acgtgaagtc tcgggcaaag cgttatgaga agctggactt ccttggggag       60

ggacagtttg ccaccgttta caaggccaga gataagaaca ccaaccaaat tgtcgccatt      120

aagaaaatca aacttggaca tagatcagaa gctaaagatg gtataaatag aaccgcctta      180

agagagataa aattattaca ggagctaagt catccaaata taattggtct ccttgatgct      240

tttggacata aatctaatat tagccttgtc tttgatttta tggaaactga tctagaggtt      300

ataataaagg ataatagtct tgtgctgaca ccatcacaca tcaaagccta catgttgatg      360

actcttcaag gattagaata tttacatcaa cattggatcc tacataggga tctgaaacca      420

aacaacttgt tgctagatga aaatggagtt ctaaaactgg cagattttgg cctggccaaa      480

tcttttggga gccccaatag agcttataca catcaggttg taaccaggtg gtatcgggcc      540

cccgagttac tatttggagc taggatgtat ggtgtaggtg tggacatgtg ggctgttggc      600

tgtatattag cagagttact tctaagggtt ccttttttgc caggagattc agaccttgat      660

cagctaacaa gaatatttga aactttgggc acaccaactg aggaacagtg gccggacatg      720

tgtagtcttc cagattatgt gacatttaag agtttccctg gaataccttt gcatcacatc      780

ttcagtgcag caggagacga cttactagat ctcatacaag gcttattctt atttaatcca      840

tgtgctcgaa ttacggccac acaggcactg aaaatgaagt atttcagtaa tcggccaggg      900

ccaacacctg gatgtcagct gccaagacca aactgtccag tggaaacctt aaaggagcaa      960

tcaaatccag ctttggcaat aaaaaggaaa agaacagagg ccttagaaca aggaggattg     1020

cccaagaaac taatttttta a                                               1041


<210>  676
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  677
<211>  1740
<212>  DNA
<213>  Homo sapiens

<400>  677
atggcgcagg aggtgtcgga gtacctgagc cagaacccgc gggtggcagc ctgggtggag       60

gcgctgcgct gcgacggcga gactgacaaa cactggcgcc accgccggga ttttttgctt      120

cgcaacgccg gggacctggc ccccgctggc ggcgctgcct ccgctagcac ggatgaagct      180

gccgacgccg agagcgggac ccgaaaccgg cagctgcagc agctcatctc cttttccatg      240

gcctgggcga accacgtctt cctcgggtgc cgataccctc aaaaagttat ggataaaata      300

cttagtatgg ctgaaggcat caaagtgaca gatgctccaa cctatacaac aagagatgaa      360

ctggttgcca aggtgaagaa aagagggata tcgagtagca atgaaggggt agaagagcca      420

tccaaaaaac gagttataga aggaaaaaac agttctgcag ttgagcaaga tcacgcaaaa      480

acctctgcca agacagaacg tgcatcagct cagcaggaaa acagttcaac gtgtataggg      540

tcggccatca aatcagagag tgggaactca gctcggagct ctggcatctc cagtcagaat      600

agctctacaa gtgatggaga tcgatctgtt tccagccaaa gcagcagcag cgtttcctct      660

caggtaacaa cggcaggatc tgggaaagct tctgaagcag aagctccaga taaacacggt      720

tcatcatttg tttccttgct gaaatccagt gtgaatagtc acatgaccca atccactgat      780

tctagacaac aaagtggatc acctaaaaag agtgctttgg aaggctcttc agcctcagct      840

tctcaaagca gctcagagat cgaggtgccc ttgttgggct cctcaggaag ctcagaggta      900

gaattgccac tattgtcttc caaacctagt tcagagacag cttcaagtgg gttaacttcc      960

aaaactagtt cagaggcaag tgtttcatca tcagttgcta aaaacagttc ctcatcaggc     1020

acatccttac tgactcccaa gagcagctct tcaacaaata catcgctgct aacttccaag     1080

agcacttccc aggtagctgc atcactacta gcttccaaga gcagctccca gaccagtgga     1140

tctctggttt ccaaaagcac ttccttagca agtgtgtccc agttggcttc taagagtagt     1200

tctcagacta gcacctcaca gttgccttct aaaagtactt cacagtcaag tgagagttct     1260

gtcaaattct cttgcaagtt aaccaatgaa gatgtgaaac agaagcaacc ttttttcaat     1320

agactatata aaacggtggc atggaagttg gtagctgttg gtggctttag tcccaatgtg     1380

aatcatggag agctcctaaa tgcagctatt gaggctctga aagcaacact ggatgtattt     1440

tttgtcccac taaaagaatt ggcagatctg cctcaaaata agagctctca agaaagtatt     1500

gtttgtgaat tgaggtgcaa gtctgtgtat ttgggcactg gctgtggaaa aagcaaagaa     1560

aatgcaaaag cagttgcatc aagagaagca ttgaagttat ttctcaagaa aaaggtggtg     1620

gtaaaaatat gtaaaaggaa atacagaggc agtgaaatag aagatctagt actccttgat     1680

gaagaatcga ggcctgtaaa cttacctcca gcactaaaac atcctcaaga attactataa     1740


<210>  678
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 
            100                 105                 110         


Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 
                245                 250                 255     


Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 
            260                 265                 270         


Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile Glu 
        275                 280                 285             


Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 
    290                 295                 300                 


Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 
305                 310                 315                 320 


Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 
                325                 330                 335     


Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 
            340                 345                 350         


Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 
        355                 360                 365             


Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 
    370                 375                 380                 


Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 
385                 390                 395                 400 


Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 
                405                 410                 415     


Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 
            420                 425                 430         


Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 
        435                 440                 445             


Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 
    450                 455                 460                 


Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 
465                 470                 475                 480 


Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 
                485                 490                 495     


Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 
            500                 505                 510         


Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 
        515                 520                 525             


Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 
    530                 535                 540                 


Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 
545                 550                 555                 560 


Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 
                565                 570                 575     


Glu Leu Leu 
            


<210>  679
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  679
atggaagaag aacttcctct tttctctgga gacagtggca agccagtaca ggctactctg       60

tcatctttga agatgttaga tgtgggaaag tggccaattt tttccctttg ttctgaagaa      120

gaactacagt taattcgtca ggcttgtgtc tttggcagtg ctggcaatga agttttatac      180

actacagtaa atgatgagat ttttgtgctt ggcacaaact gctgtggctg tttggggtta      240

ggtgacgtcc agagcaccat tgaacctcgg agactggatt ctttaaatgg caaaaaaata      300

gcctgcctca gctatgggag tggtccacat attgtccttg caacaacaga aggagaagtc      360

tttacctggg gtcataatgc ttatagccag ctgggcaatg ggacaactaa tcatggttta      420

gtgccctgtc atatctctac taatctgtca aacaaacaag tcattgaagt tgcctgtggg      480

tcttaccatt ctttggtgct aacatctgat ggagaggtat ttgcctgggg ttataataac      540

tctgggcagg taggatctgg atcaacagtt aatcagccaa tccctcgaag agtcactggc      600

tgcctacaaa ataaagtagt tgtgaccata gcatgtgggc agatgtgctg catggcagta      660

gtagacacgg gggaggtcta tgtctggggt tacaacggaa acgggcagct tggactcggc      720

aacagtggca accagccaac cccttgcaga gtggcagctt tgcaaggcat ccgtgtccag      780

agggtcgcct gtggctacgc acacacatta gtattaacag atgaaggcca agtgtatgct      840

tggggcgcca attcttatgg gcagttgggc actggcaata aaagcaacca gtcctatcct      900

actcctgtca ctgtggaaaa ggacaggatt atcgagattg cagcctgtca ctccacacac      960

acgtctgcgg ccaagacgca gggtgggcac gtgtacatgt ggggccagtg ccggggtcag     1020

tccgtgatcc tcccgcacct cacccacttc tcctgcactg acgacgtgtt tgcctgcttt     1080

gccacgcccg ccgtcacgtg gcgcctcctc tccgtggaac ctgatgacca cctcacagtg     1140

gctgagtcac tgaagaggga atttgacaac ccggacactg cagacctgaa gtttctagtt     1200

gatggaaagt acatttatgc acataaagtc cttctcaaga ttcgatgtga gcattttcgt     1260

tcgtcattgg aagataacga ggatgatatt gtagaaatga gtgaattttc atatcctgtt     1320

taccgggcct tcctggaata cctatacaca gacagcatca gcctttctcc tgaggaggca     1380

gtaggactgc tagacttggc tacattttat agagaaaatc gtttgaaaaa gctctgccaa     1440

caaactatca agcaaggcat ctgcgaggag aatgccatcg ctctgctctc ggctgcggtg     1500

aagtatgatg cacaggattt agaagaattc tgcttcaggt tttgcataaa ccatctgact     1560

gtagtaacac aaacatcagg ttttgcagaa atggaccatg atctcctgaa gaactttatc     1620

agcaaagcaa gcagagttgg agcctttaaa aattga                               1656


<210>  680
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Glu Glu Glu Leu Pro Leu Phe Ser Gly Asp Ser Gly Lys Pro Val 
1               5                   10                  15      


Gln Ala Thr Leu Ser Ser Leu Lys Met Leu Asp Val Gly Lys Trp Pro 
            20                  25                  30          


Ile Phe Ser Leu Cys Ser Glu Glu Glu Leu Gln Leu Ile Arg Gln Ala 
        35                  40                  45              


Cys Val Phe Gly Ser Ala Gly Asn Glu Val Leu Tyr Thr Thr Val Asn 
    50                  55                  60                  


Asp Glu Ile Phe Val Leu Gly Thr Asn Cys Cys Gly Cys Leu Gly Leu 
65                  70                  75                  80  


Gly Asp Val Gln Ser Thr Ile Glu Pro Arg Arg Leu Asp Ser Leu Asn 
                85                  90                  95      


Gly Lys Lys Ile Ala Cys Leu Ser Tyr Gly Ser Gly Pro His Ile Val 
            100                 105                 110         


Leu Ala Thr Thr Glu Gly Glu Val Phe Thr Trp Gly His Asn Ala Tyr 
        115                 120                 125             


Ser Gln Leu Gly Asn Gly Thr Thr Asn His Gly Leu Val Pro Cys His 
    130                 135                 140                 


Ile Ser Thr Asn Leu Ser Asn Lys Gln Val Ile Glu Val Ala Cys Gly 
145                 150                 155                 160 


Ser Tyr His Ser Leu Val Leu Thr Ser Asp Gly Glu Val Phe Ala Trp 
                165                 170                 175     


Gly Tyr Asn Asn Ser Gly Gln Val Gly Ser Gly Ser Thr Val Asn Gln 
            180                 185                 190         


Pro Ile Pro Arg Arg Val Thr Gly Cys Leu Gln Asn Lys Val Val Val 
        195                 200                 205             


Thr Ile Ala Cys Gly Gln Met Cys Cys Met Ala Val Val Asp Thr Gly 
    210                 215                 220                 


Glu Val Tyr Val Trp Gly Tyr Asn Gly Asn Gly Gln Leu Gly Leu Gly 
225                 230                 235                 240 


Asn Ser Gly Asn Gln Pro Thr Pro Cys Arg Val Ala Ala Leu Gln Gly 
                245                 250                 255     


Ile Arg Val Gln Arg Val Ala Cys Gly Tyr Ala His Thr Leu Val Leu 
            260                 265                 270         


Thr Asp Glu Gly Gln Val Tyr Ala Trp Gly Ala Asn Ser Tyr Gly Gln 
        275                 280                 285             


Leu Gly Thr Gly Asn Lys Ser Asn Gln Ser Tyr Pro Thr Pro Val Thr 
    290                 295                 300                 


Val Glu Lys Asp Arg Ile Ile Glu Ile Ala Ala Cys His Ser Thr His 
305                 310                 315                 320 


Thr Ser Ala Ala Lys Thr Gln Gly Gly His Val Tyr Met Trp Gly Gln 
                325                 330                 335     


Cys Arg Gly Gln Ser Val Ile Leu Pro His Leu Thr His Phe Ser Cys 
            340                 345                 350         


Thr Asp Asp Val Phe Ala Cys Phe Ala Thr Pro Ala Val Thr Trp Arg 
        355                 360                 365             


Leu Leu Ser Val Glu Pro Asp Asp His Leu Thr Val Ala Glu Ser Leu 
    370                 375                 380                 


Lys Arg Glu Phe Asp Asn Pro Asp Thr Ala Asp Leu Lys Phe Leu Val 
385                 390                 395                 400 


Asp Gly Lys Tyr Ile Tyr Ala His Lys Val Leu Leu Lys Ile Arg Cys 
                405                 410                 415     


Glu His Phe Arg Ser Ser Leu Glu Asp Asn Glu Asp Asp Ile Val Glu 
            420                 425                 430         


Met Ser Glu Phe Ser Tyr Pro Val Tyr Arg Ala Phe Leu Glu Tyr Leu 
        435                 440                 445             


Tyr Thr Asp Ser Ile Ser Leu Ser Pro Glu Glu Ala Val Gly Leu Leu 
    450                 455                 460                 


Asp Leu Ala Thr Phe Tyr Arg Glu Asn Arg Leu Lys Lys Leu Cys Gln 
465                 470                 475                 480 


Gln Thr Ile Lys Gln Gly Ile Cys Glu Glu Asn Ala Ile Ala Leu Leu 
                485                 490                 495     


Ser Ala Ala Val Lys Tyr Asp Ala Gln Asp Leu Glu Glu Phe Cys Phe 
            500                 505                 510         


Arg Phe Cys Ile Asn His Leu Thr Val Val Thr Gln Thr Ser Gly Phe 
        515                 520                 525             


Ala Glu Met Asp His Asp Leu Leu Lys Asn Phe Ile Ser Lys Ala Ser 
    530                 535                 540                 


Arg Val Gly Ala Phe Lys Asn 
545                 550     


<210>  681
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  681
atggacatcg ccatccacca cccctggatc cgccgcccct tctttccttt ccactccccc       60

agccgcctct ttgaccagtt cttcggagag cacctgttgg agtctgatct tttcccgacg      120

tctacttccc tgagtccctt ctaccttcgg ccaccctcct tcctgcgggc acccagctgg      180

tttgacactg gactctcaga gatgcgcctg gagaaggaca ggttctctgt caacctggat      240

gtgaagcact tctccccaga ggaactcaaa gttaaggtgt tgggagatgt gattgaggtg      300

catggaaaac atgaagagcg ccaggatgaa catggtttca tctccaggga gttccacagg      360

aaataccgga tcccagctga tgtagaccct ctcaccatta cttcatccct gtcatctgat      420

ggggtcctca ctgtgaatgg accaaggaaa caggtctctg gccctgagcg caccattccc      480

atcacccgtg aagagaagcc tgctgtcacc gcagccccca agaaatag                   528


<210>  682
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
1               5                   10                  15      


Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
            20                  25                  30          


Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
        35                  40                  45              


Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
    50                  55                  60                  


Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                85                  90                  95      


Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
            100                 105                 110         


Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
        115                 120                 125             


Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
    130                 135                 140                 


Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
145                 150                 155                 160 


Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys 
                165                 170                 175 


<210>  683
<211>  785
<212>  DNA
<213>  Homo sapiens

<400>  683
atggcgagta gcagcggctc caaggctgaa ttcattgtcg gagggaaata taaactggta       60

cggaagatcg ggtctggctc cttcggggac atctatttgg cgatcaacat caccaacggc      120

gaggaagtgg cagtgaagct agaatctcag aaggccaggc atccccagtt gctgtacgag      180

agcaagctct ataagattct tcaaggtggg gttggcatcc cccacatacg gtggtatggt      240

caggaaaaag actacaatgt actagtcatg gatcttctgg gacctagcct cgaagacctc      300

ttcaatttct gttcaagaag gttcacaatg aaaactgtac ttatgttagc tgaccagatg      360

atcagtagaa ttgaatatgt gcatacaaag aattttatac acagagacat taaaccagat      420

aacttcctaa tgggtattgg gcgtcactgt aataagtgtt tagaatctcc agtggggaag      480

aggaaaagaa gcatgactgt tagtacttct caggacccat ctttctcagg attaaaccag      540

ttattcctta ttgattttgg tttggccaaa aagtacagag acaacaggac aaggcaacac      600

ataccataca gagaagataa aaacctcact ggcactgccc gatatgctag catcaatgca      660

catcttggta ttgagcagag tcgccgagat gacatggaat cattaggata tgttttgatg      720

tattttaata gaaccagcct gccatggcaa gggctaaagg ctgcaacaaa aaaaaaaaaa      780

aaaaa                                                                  785


<210>  684
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Thr Val Ser Thr Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr 
                245                 250                 255     


Lys Lys Lys Lys Lys 
            260     


<210>  685
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  685
atgccgaact ggggaggagg caagaaatgt ggggtgtgtc agaagacggt ttactttgcc       60

gaagaggttc agtgcgaagg caacagcttc cataaatcct gcttcctgtg catggtctgc      120

aagaagaatc tggacagtac cactgtggcc gtgcatggtg aggagattta ctgcaagtcc      180

tgctacggca agaagtatgg gcccaaaggc tatggctacg ggcagggcgc aggcaccctc      240

agcactgaca agggggagtc gctgggtatc aagcacgagg aagcccctgg ccacaggccc      300

accaccaacc ccaatgcatc caaatttgcc cagaagattg gtggctccga gcgctgcccc      360

cgatgcagcc aggcagtcta tgctgcggag aaggtgattg gtgctgggaa gtcctggcat      420

aaggcctgct ttcgatgtgc caagtgtggc aaaggccttg agtcaaccac cctggcagac      480

aaggatggcg agatttactg caaaggatgt tatgctaaaa acttcgggcc caagggcttt      540

ggttttgggc aaggagctgg ggccttggtc cactctgagt ga                         582


<210>  686
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Pro Asn Trp Gly Gly Gly Lys Lys Cys Gly Val Cys Gln Lys Thr 
1               5                   10                  15      


Val Tyr Phe Ala Glu Glu Val Gln Cys Glu Gly Asn Ser Phe His Lys 
            20                  25                  30          


Ser Cys Phe Leu Cys Met Val Cys Lys Lys Asn Leu Asp Ser Thr Thr 
        35                  40                  45              


Val Ala Val His Gly Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys 
    50                  55                  60                  


Lys Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu 
65                  70                  75                  80  


Ser Thr Asp Lys Gly Glu Ser Leu Gly Ile Lys His Glu Glu Ala Pro 
                85                  90                  95      


Gly His Arg Pro Thr Thr Asn Pro Asn Ala Ser Lys Phe Ala Gln Lys 
            100                 105                 110         


Ile Gly Gly Ser Glu Arg Cys Pro Arg Cys Ser Gln Ala Val Tyr Ala 
        115                 120                 125             


Ala Glu Lys Val Ile Gly Ala Gly Lys Ser Trp His Lys Ala Cys Phe 
    130                 135                 140                 


Arg Cys Ala Lys Cys Gly Lys Gly Leu Glu Ser Thr Thr Leu Ala Asp 
145                 150                 155                 160 


Lys Asp Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly 
                165                 170                 175     


Pro Lys Gly Phe Gly Phe Gly Gln Gly Ala Gly Ala Leu Val His Ser 
            180                 185                 190         


Glu 
    


<210>  687
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  687
atggaggtga ccggggacgc cggggtacca gaatctggcg agatccggac tctaaagccg       60

tgtctgctgc gccgcaacta cagccgcgaa cagcacggcg tggccgcctc ctgcctcgaa      120

gacctgagga gcaaggcctg tgacattctg gccattgata agtccctgac accagtcacc      180

ctggtcctgg cagaggatgg caccatagtg gatgatgacg attactttct gtgtctacct      240

tccaatacta agtttgtggc attggctagt aatgagaaat gggcatacaa caattcagat      300

ggaggtacag cttggatttc ccaagagtcc tttgatgtag atgaaacaga cagcggggca      360

gggttgaagt ggaagaatgt ggccaggcag ctgaaagaag atctgtccag catcatcctc      420

ctatcagagg aggacctcca gatgcttgtt gacgctccct gctcagacct ggctcaggaa      480

ctacgtcaga gttgtgccac cgtccagcgg ctgcagcaca cactccaaca ggtgcttgac      540

caaagagagg aagtgcgtca gtccaagcag ctcctgcagc tgtacctcca ggctttggag      600

aaagagggca gcctcttgtc aaagcaggaa gagtccaaag ctgcctttgg tgaggaggtg      660

gatgcagtag acacgggtat cagcagagag acctcctcgg acgttgcgct ggcgagccac      720

atccttactg cactgaggga gaagcaggct ccagagctga gcttatctag tcaggatttg      780

gagttggtta ccaaggaaga ccccaaagca ctggctgttg ccttgaactg ggacataaag      840

aagacggaga ctgttcagga ggcctgtgag cgggagctcg ccctgcgcct gcagcagacg      900

cagagcttgc attctctccg gagcatctca gcaagcaagg cctcaccacc tggtgacctg      960

cagaatccta agcgagccag acaggatccc acatag                                996


<210>  688
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Glu Val Thr Gly Asp Ala Gly Val Pro Glu Ser Gly Glu Ile Arg 
1               5                   10                  15      


Thr Leu Lys Pro Cys Leu Leu Arg Arg Asn Tyr Ser Arg Glu Gln His 
            20                  25                  30          


Gly Val Ala Ala Ser Cys Leu Glu Asp Leu Arg Ser Lys Ala Cys Asp 
        35                  40                  45              


Ile Leu Ala Ile Asp Lys Ser Leu Thr Pro Val Thr Leu Val Leu Ala 
    50                  55                  60                  


Glu Asp Gly Thr Ile Val Asp Asp Asp Asp Tyr Phe Leu Cys Leu Pro 
65                  70                  75                  80  


Ser Asn Thr Lys Phe Val Ala Leu Ala Ser Asn Glu Lys Trp Ala Tyr 
                85                  90                  95      


Asn Asn Ser Asp Gly Gly Thr Ala Trp Ile Ser Gln Glu Ser Phe Asp 
            100                 105                 110         


Val Asp Glu Thr Asp Ser Gly Ala Gly Leu Lys Trp Lys Asn Val Ala 
        115                 120                 125             


Arg Gln Leu Lys Glu Asp Leu Ser Ser Ile Ile Leu Leu Ser Glu Glu 
    130                 135                 140                 


Asp Leu Gln Met Leu Val Asp Ala Pro Cys Ser Asp Leu Ala Gln Glu 
145                 150                 155                 160 


Leu Arg Gln Ser Cys Ala Thr Val Gln Arg Leu Gln His Thr Leu Gln 
                165                 170                 175     


Gln Val Leu Asp Gln Arg Glu Glu Val Arg Gln Ser Lys Gln Leu Leu 
            180                 185                 190         


Gln Leu Tyr Leu Gln Ala Leu Glu Lys Glu Gly Ser Leu Leu Ser Lys 
        195                 200                 205             


Gln Glu Glu Ser Lys Ala Ala Phe Gly Glu Glu Val Asp Ala Val Asp 
    210                 215                 220                 


Thr Gly Ile Ser Arg Glu Thr Ser Ser Asp Val Ala Leu Ala Ser His 
225                 230                 235                 240 


Ile Leu Thr Ala Leu Arg Glu Lys Gln Ala Pro Glu Leu Ser Leu Ser 
                245                 250                 255     


Ser Gln Asp Leu Glu Leu Val Thr Lys Glu Asp Pro Lys Ala Leu Ala 
            260                 265                 270         


Val Ala Leu Asn Trp Asp Ile Lys Lys Thr Glu Thr Val Gln Glu Ala 
        275                 280                 285             


Cys Glu Arg Glu Leu Ala Leu Arg Leu Gln Gln Thr Gln Ser Leu His 
    290                 295                 300                 


Ser Leu Arg Ser Ile Ser Ala Ser Lys Ala Ser Pro Pro Gly Asp Leu 
305                 310                 315                 320 


Gln Asn Pro Lys Arg Ala Arg Gln Asp Pro Thr 
                325                 330     


<210>  689
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  689
atggaaaccc tttgcctcag ggcatccttt tggctggcac tggttggatg tgtaatcagt       60

gataatcctg agagatacag cacaaatcta agcaatcatg tggatgattt caccactttt      120

cgtggcacag agctcagctt cctggttacc actcatcaac ccactaattt ggtcctaccc      180

agcaatggct caatgcacaa ctattgccca cagcagacta aaattacttc agctttcaaa      240

tacattaaca ctgtgatatc ttgtactatt ttcatcgtgg gaatggtggg gaatgcaact      300

ctgctcagga tcatttacca gaacaaatgt atgaggaatg gccccaacgc gctgatagcc      360

agtcttgccc ttggagacct tatctatgtg gtcattgatc tccctatcaa tgtatttaag      420

ctgctggctg ggcgctggcc ttttgatcac aatgactttg gcgtatttct ttgcaagctg      480

ttcccctttt tgcagaagtc ctcggtgggg atcaccgtcc tcaacctctg cgctcttagt      540

gttgacaggt acagagcagt tgcctcctgg agtcgtgttc agggaattgg gattcctttg      600

gtaactgcca ttgaaattgt ctccatctgg atcctgtcct ttatcctggc cattcctgaa      660

gcgattggct tcgtcatggt accctttgaa tataggggtg aacagcataa aacctgtatg      720

ctcaatgcca catcaaaatt catggagttc taccaagatg taaaggactg gtggctcttc      780

gggttctatt tctgtatgcc cttggtgtgc actgcgatct tctacaccct catgacttgt      840

gagatgttga acagaaggaa tggcagcttg agaattgccc tcagtgaaca tcttaagcag      900

cgtcgagaag tggcaaaaac agttttctgc ttggttgtaa tttttgctct ttgctggttc      960

cctcttcatt taagccgtat attgaagaaa actgtgtata acgagatgga caagaaccga     1020

tgtgaattac ttagtttctt actgctcatg gattacatcg gtattaactt ggcaaccatg     1080

aattcatgta taaaccccat agctctgtat tttgtgagca agaaatttaa aaattgtttc     1140

cagtcatgcc tctgctgctg ctgttaccag tccaaaagtc tgatgacctc ggtccccatg     1200

aacggaacaa gcatccagtg gaagaaccac gatcaaaaca accacaacac agaccggagc     1260

agccataagg acagcatgaa ctga                                            1284


<210>  690
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         


<210>  691
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  691
atggccattg ccacgtcgac ccagctggcc cgggcactgt atgacaacac cgctgagtcc       60

ccccaggagc tgtccttccg ccgaggggat gtcctacggg tcctgcagag agagggcgct      120

ggtggactgg acggctggtg cctctgctcc ctacacggcc agcagggcat tgtgcccgcc      180

aacagggtga agctcttgcc tgctggccca gcacccaagc ccagcctctc tcctgcgtcc      240

ccagcccagc ctggctcacc atatccagcc ccagatcaca gcaatgagga ccaggaggtg      300

tatgtggtgc cgcccccagc tcggccctgt ccaacctcag gacctccagc tggaccttgc      360

ccaccctctc ctgacctcat ctacaaaatc cccagagcta gtgggaccca gctggctgct      420

cccagagatg ccttggaggt ctacgatgtg ccccccaccg ccctccgggt gccctccagt      480

ggcccctatg actgccctgc ctccttttcc caccctctga cccgggttgc cccgcagccc      540

cctggagagg atgatgctcc ctatgatgtg cctctgaccc caaagccacc tgcagagctg      600

gaaccagatc tggagtggga aggaggccgg gagccggggc cccccatcta tgctgccccc      660

tccaacctga aacgagcgtc agccttactc aatttgtatg aagcacccga ggaactgctg      720

gcagacgggg agggcggggg cactgatgag gggatctacg atgtgcctct gctggggcca      780

gaggctcccc cttctccaga gccccctgga gccttggcct cccatgacca ggacaccctg      840

gcccagcttc tggccagaag ccccccaccc ccacacaggc cccggctccc ctcagctgag      900

agcctgtccc gccgccctct gcctgccctg cctgtccctg aggcccccag cccctcccca      960

gtgccctctc ctgccccagg ccggaagggc agcatccagg accggcctct gcccccaccc     1020

ccaccccgcc tgcctggtta tggaggcccc aaggtcgagg gggatccaga gggcagggag     1080

atggaggatg acccagcagg acaccacaat gagtacgagg gcattccgat ggccgaggag     1140

tatgactatg tccacctgaa gggcatggac aaagctcagg gatctaggcc cccggatcag     1200

gcctgcacag gggatcctga actgcccgag agggggatgc cggcgccgca ggaggccctg     1260

tccccagggg agccactggt tgtgtccacc ggagatctgc agctcctgta cttctatgct     1320

gggcaatgcc agagccacta ctcagccctg caggcagccg tggcagccct gatgtccagt     1380

acccaggcta atcagccccc gcgccttttc gtgccccaca gcaagagggt ggtggtggct     1440

gctcatcgcc tggtgtttgt tggggacacc ctgggccggc tggcagcctc tgcccctctg     1500

agagcacagg tcagggctgc aggtacagca ctgggccagg cattgcgggc cactgtgctg     1560

gctgtcaagg gagctgccct gggctaccca tccagccctg ccatccaaga gatggtgcag     1620

tgtgtaacag aactggcagg gcaggccctg caattcacta ccctgctcac tagcctggct     1680

ccatga                                                                1686


<210>  692
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Ala Ile Ala Thr Ser Thr Gln Leu Ala Arg Ala Leu Tyr Asp Asn 
1               5                   10                  15      


Thr Ala Glu Ser Pro Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu 
            20                  25                  30          


Arg Val Leu Gln Arg Glu Gly Ala Gly Gly Leu Asp Gly Trp Cys Leu 
        35                  40                  45              


Cys Ser Leu His Gly Gln Gln Gly Ile Val Pro Ala Asn Arg Val Lys 
    50                  55                  60                  


Leu Leu Pro Ala Gly Pro Ala Pro Lys Pro Ser Leu Ser Pro Ala Ser 
65                  70                  75                  80  


Pro Ala Gln Pro Gly Ser Pro Tyr Pro Ala Pro Asp His Ser Asn Glu 
                85                  90                  95      


Asp Gln Glu Val Tyr Val Val Pro Pro Pro Ala Arg Pro Cys Pro Thr 
            100                 105                 110         


Ser Gly Pro Pro Ala Gly Pro Cys Pro Pro Ser Pro Asp Leu Ile Tyr 
        115                 120                 125             


Lys Ile Pro Arg Ala Ser Gly Thr Gln Leu Ala Ala Pro Arg Asp Ala 
    130                 135                 140                 


Leu Glu Val Tyr Asp Val Pro Pro Thr Ala Leu Arg Val Pro Ser Ser 
145                 150                 155                 160 


Gly Pro Tyr Asp Cys Pro Ala Ser Phe Ser His Pro Leu Thr Arg Val 
                165                 170                 175     


Ala Pro Gln Pro Pro Gly Glu Asp Asp Ala Pro Tyr Asp Val Pro Leu 
            180                 185                 190         


Thr Pro Lys Pro Pro Ala Glu Leu Glu Pro Asp Leu Glu Trp Glu Gly 
        195                 200                 205             


Gly Arg Glu Pro Gly Pro Pro Ile Tyr Ala Ala Pro Ser Asn Leu Lys 
    210                 215                 220                 


Arg Ala Ser Ala Leu Leu Asn Leu Tyr Glu Ala Pro Glu Glu Leu Leu 
225                 230                 235                 240 


Ala Asp Gly Glu Gly Gly Gly Thr Asp Glu Gly Ile Tyr Asp Val Pro 
                245                 250                 255     


Leu Leu Gly Pro Glu Ala Pro Pro Ser Pro Glu Pro Pro Gly Ala Leu 
            260                 265                 270         


Ala Ser His Asp Gln Asp Thr Leu Ala Gln Leu Leu Ala Arg Ser Pro 
        275                 280                 285             


Pro Pro Pro His Arg Pro Arg Leu Pro Ser Ala Glu Ser Leu Ser Arg 
    290                 295                 300                 


Arg Pro Leu Pro Ala Leu Pro Val Pro Glu Ala Pro Ser Pro Ser Pro 
305                 310                 315                 320 


Val Pro Ser Pro Ala Pro Gly Arg Lys Gly Ser Ile Gln Asp Arg Pro 
                325                 330                 335     


Leu Pro Pro Pro Pro Pro Arg Leu Pro Gly Tyr Gly Gly Pro Lys Val 
            340                 345                 350         


Glu Gly Asp Pro Glu Gly Arg Glu Met Glu Asp Asp Pro Ala Gly His 
        355                 360                 365             


His Asn Glu Tyr Glu Gly Ile Pro Met Ala Glu Glu Tyr Asp Tyr Val 
    370                 375                 380                 


His Leu Lys Gly Met Asp Lys Ala Gln Gly Ser Arg Pro Pro Asp Gln 
385                 390                 395                 400 


Ala Cys Thr Gly Asp Pro Glu Leu Pro Glu Arg Gly Met Pro Ala Pro 
                405                 410                 415     


Gln Glu Ala Leu Ser Pro Gly Glu Pro Leu Val Val Ser Thr Gly Asp 
            420                 425                 430         


Leu Gln Leu Leu Tyr Phe Tyr Ala Gly Gln Cys Gln Ser His Tyr Ser 
        435                 440                 445             


Ala Leu Gln Ala Ala Val Ala Ala Leu Met Ser Ser Thr Gln Ala Asn 
    450                 455                 460                 


Gln Pro Pro Arg Leu Phe Val Pro His Ser Lys Arg Val Val Val Ala 
465                 470                 475                 480 


Ala His Arg Leu Val Phe Val Gly Asp Thr Leu Gly Arg Leu Ala Ala 
                485                 490                 495     


Ser Ala Pro Leu Arg Ala Gln Val Arg Ala Ala Gly Thr Ala Leu Gly 
            500                 505                 510         


Gln Ala Leu Arg Ala Thr Val Leu Ala Val Lys Gly Ala Ala Leu Gly 
        515                 520                 525             


Tyr Pro Ser Ser Pro Ala Ile Gln Glu Met Val Gln Cys Val Thr Glu 
    530                 535                 540                 


Leu Ala Gly Gln Ala Leu Gln Phe Thr Thr Leu Leu Thr Ser Leu Ala 
545                 550                 555                 560 


Pro 
    


<210>  693
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  693
atggaatcat ctccatttaa tagacggcaa tggacctcac tatcattgag ggtaacagcc       60

aaagaacttt ctcttgtcaa caagaacaag tcatcggcta ttgtggaaat attctccaag      120

taccagaaag cagctgaaga aacaaacatg gagaagaaga gaagtaacac cgaaaatctc      180

tcccagcact ttagaaaggg gaccctgact gtgttaaaga agaagtggga gaacccaggg      240

ctgggagcag agtctcacac agactctcta cggaacagca gcactgagat taggcacaga      300

gcagaccatc ctcctgctga agtgacaagc cacgctgctt ctggagccaa agctgaccaa      360

gaagaacaaa tccaccccag atctagactc aggtcacctc ctgaagccct cgttcagggt      420

cgatatcccc acatcaagga cggtgaggat cttaaagacc actcaacaga aagtaaaaaa      480

atggaaaatt gtctaggaga atccaggcat gaagtagaaa aatcagaaat cagtgaaaac      540

acagatgctt cgggcaaaat agagaaatat aatgttccgc tgaacaggct taagatgatg      600

tttgagaaag gtgaaccaac tcaaactaag attctccggg cccaaagccg aagtgcaagt      660

ggaaggaaga tctctgaaaa cagctattct ctagatgacc tggaaatagg cccaggtcag      720

ttgtcatctt ctacatttga ctcggagaaa aatgagagta gacgaaatct ggaacttcca      780

cgcctctcag aaacctctat aaaggatcga atggccaagt accaggcagc tgtgtccaaa      840

caaagcagct caaccaacta tacaaatgag ctgaaagcca gtggtggcga aatcaaaatt      900

cataaaatgg agcaaaagga gaatgtgccc ccaggtcctg aggtctgcat cacccatcag      960

gaaggggaaa agatttctgc aaatgagaat agcctggcag tccgttccac ccctgccgaa     1020

gatgactccc gtgactccca ggttaagagt gaggttcaac agcctgtcca tcccaagcca     1080

ctaagtccag attccagagc ctccagtctt tctgaaagtt ctcctcccaa agcaatgaag     1140

aagtttcagg cacctgcaag agagacctgc gtggaatgtc agaagacagt ctatccaatg     1200

gagcgtctct tggccaacca gcaggtgttt cacatcagct gcttccgttg ctcctattgc     1260

aacaacaaac tcagtctagg aacatatgca tctttacatg gaagaatcta ttgtaagcct     1320

cacttcaatc aactctttaa atctaagggc aactatgatg aaggctttgg gcacagacca     1380

cacaaggatc tatgggcaag caaaaatgaa aacgaagaga ttttggagag accagcccag     1440

cttgcaaatg caagggagac ccctcacagc ccaggggtag aagatgcccc tattgctaag     1500

gtgggtgtcc tggctgcaag tatggaagcc aaggcctcct ctcagcagga gaaggaagac     1560

aagccagctg aaaccaagaa gctgaggatc gcctggccac cccccactga acttggaagt     1620

tcaggaagtg ccttggagga agggatcaaa atgtcaaagc ccaaatggcc tcctgaagac     1680

gaaatcagca agcccgaagt tcctgaggat gtcgatctag atctgaagaa gctaagacga     1740

tcttcttcac tgaaggaaag aagccgccca ttcactgtag cagcttcatt tcaaagcacc     1800

tctgtcaaga gcccaaaaac tgtgtcccca cctatcagga aaggctggag catgtcagag     1860

cagagtgaag agtctgtggg tggaagagtt gcagaaagga aacaagtgga aaatgccaag     1920

gcttctaaga agaatgggaa tgtgggaaaa acaacctggc aaaacaaaga atctaaagga     1980

gagacaggga agagaagtaa ggaaggtcat agtttggaga tggagaatga gaatcttgta     2040

gaaaatggtg cagactccga tgaagatgat aacagcttcc tcaaacaaca atctccacaa     2100

gaacccaagt ctctgaattg gtcgagtttt gtagacaaca cctttgctga agaattcact     2160

actcagaatc agaaatccca ggatgtggaa ctctgggagg gagaagtggt caaagagctc     2220

tctgtggaag aacagataaa gagaaatcgg tattatgatg aggatgagga tgaagagtga     2280


<210>  694
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Glu Ser Ser Pro Phe Asn Arg Arg Gln Trp Thr Ser Leu Ser Leu 
1               5                   10                  15      


Arg Val Thr Ala Lys Glu Leu Ser Leu Val Asn Lys Asn Lys Ser Ser 
            20                  25                  30          


Ala Ile Val Glu Ile Phe Ser Lys Tyr Gln Lys Ala Ala Glu Glu Thr 
        35                  40                  45              


Asn Met Glu Lys Lys Arg Ser Asn Thr Glu Asn Leu Ser Gln His Phe 
    50                  55                  60                  


Arg Lys Gly Thr Leu Thr Val Leu Lys Lys Lys Trp Glu Asn Pro Gly 
65                  70                  75                  80  


Leu Gly Ala Glu Ser His Thr Asp Ser Leu Arg Asn Ser Ser Thr Glu 
                85                  90                  95      


Ile Arg His Arg Ala Asp His Pro Pro Ala Glu Val Thr Ser His Ala 
            100                 105                 110         


Ala Ser Gly Ala Lys Ala Asp Gln Glu Glu Gln Ile His Pro Arg Ser 
        115                 120                 125             


Arg Leu Arg Ser Pro Pro Glu Ala Leu Val Gln Gly Arg Tyr Pro His 
    130                 135                 140                 


Ile Lys Asp Gly Glu Asp Leu Lys Asp His Ser Thr Glu Ser Lys Lys 
145                 150                 155                 160 


Met Glu Asn Cys Leu Gly Glu Ser Arg His Glu Val Glu Lys Ser Glu 
                165                 170                 175     


Ile Ser Glu Asn Thr Asp Ala Ser Gly Lys Ile Glu Lys Tyr Asn Val 
            180                 185                 190         


Pro Leu Asn Arg Leu Lys Met Met Phe Glu Lys Gly Glu Pro Thr Gln 
        195                 200                 205             


Thr Lys Ile Leu Arg Ala Gln Ser Arg Ser Ala Ser Gly Arg Lys Ile 
    210                 215                 220                 


Ser Glu Asn Ser Tyr Ser Leu Asp Asp Leu Glu Ile Gly Pro Gly Gln 
225                 230                 235                 240 


Leu Ser Ser Ser Thr Phe Asp Ser Glu Lys Asn Glu Ser Arg Arg Asn 
                245                 250                 255     


Leu Glu Leu Pro Arg Leu Ser Glu Thr Ser Ile Lys Asp Arg Met Ala 
            260                 265                 270         


Lys Tyr Gln Ala Ala Val Ser Lys Gln Ser Ser Ser Thr Asn Tyr Thr 
        275                 280                 285             


Asn Glu Leu Lys Ala Ser Gly Gly Glu Ile Lys Ile His Lys Met Glu 
    290                 295                 300                 


Gln Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys Ile Thr His Gln 
305                 310                 315                 320 


Glu Gly Glu Lys Ile Ser Ala Asn Glu Asn Ser Leu Ala Val Arg Ser 
                325                 330                 335     


Thr Pro Ala Glu Asp Asp Ser Arg Asp Ser Gln Val Lys Ser Glu Val 
            340                 345                 350         


Gln Gln Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg Ala Ser 
        355                 360                 365             


Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe Gln Ala 
    370                 375                 380                 


Pro Ala Arg Glu Thr Cys Val Glu Cys Gln Lys Thr Val Tyr Pro Met 
385                 390                 395                 400 


Glu Arg Leu Leu Ala Asn Gln Gln Val Phe His Ile Ser Cys Phe Arg 
                405                 410                 415     


Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala Ser Leu 
            420                 425                 430         


His Gly Arg Ile Tyr Cys Lys Pro His Phe Asn Gln Leu Phe Lys Ser 
        435                 440                 445             


Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys Asp Leu 
    450                 455                 460                 


Trp Ala Ser Lys Asn Glu Asn Glu Glu Ile Leu Glu Arg Pro Ala Gln 
465                 470                 475                 480 


Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu Asp Ala 
                485                 490                 495     


Pro Ile Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala Lys Ala 
            500                 505                 510         


Ser Ser Gln Gln Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys Lys Leu 
        515                 520                 525             


Arg Ile Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly Ser Ala 
    530                 535                 540                 


Leu Glu Glu Gly Ile Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Asp 
545                 550                 555                 560 


Glu Ile Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp Leu Lys 
                565                 570                 575     


Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro Phe Thr 
            580                 585                 590         


Val Ala Ala Ser Phe Gln Ser Thr Ser Val Lys Ser Pro Lys Thr Val 
        595                 600                 605             


Ser Pro Pro Ile Arg Lys Gly Trp Ser Met Ser Glu Gln Ser Glu Glu 
    610                 615                 620                 


Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gln Val Glu Asn Ala Lys 
625                 630                 635                 640 


Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gln Asn Lys 
                645                 650                 655     


Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His Ser Leu 
            660                 665                 670         


Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser Asp Glu 
        675                 680                 685             


Asp Asp Asn Ser Phe Leu Lys Gln Gln Ser Pro Gln Glu Pro Lys Ser 
    690                 695                 700                 


Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu Phe Thr 
705                 710                 715                 720 


Thr Gln Asn Gln Lys Ser Gln Asp Val Glu Leu Trp Glu Gly Glu Val 
                725                 730                 735     


Val Lys Glu Leu Ser Val Glu Glu Gln Ile Lys Arg Asn Arg Tyr Tyr 
            740                 745                 750         


Asp Glu Asp Glu Asp Glu Glu 
        755                 


<210>  695
<211>  2469
<212>  DNA
<213>  Homo sapiens

<400>  695
atgaatggtc atatttctaa tcatcccagt agttttggaa tgtacccatc tcagatgaat       60

ggctacggat catcacctac cttttcccag acggacagag aacatggttc aaaaacaagt      120

gcaaaggccc tttatgaaca aaggaagaat tatgcacggg acagtgtcag cagtgtgtca      180

gatatatctc aataccgtgt tgaacacttg actacctttg tcctggatcg gaaagatgct      240

atgatcactg ttgatgatgg aataaggaaa ttgaaattgc ttgatgccaa gggcaaagtg      300

tggactcaag atatgattct tcaagtggat gacagagctg tgagcctgat tgatttagaa      360

tcaaagaatg aactggagaa ttttccttta aacacaatcc agcactgcca agctgtgatg      420

cattcatgca gctatgattc agttcttgca ctggtgtgca aagagccaac ccagaacaag      480

ccagatcttc atctcttcca gtgtgatgag gttaaggcaa acctaattag tgaagatatt      540

gaaagtgcaa tcagtgacag taaaggaggg aaacagaaga ggcggcccga cgccctgagg      600

atgatttcca atgcagaccc tagtataccg cctccaccca gagctcctgc ccctgcgccc      660

cctgggaccg tcacccaggt ggatgttaga agtcgagtgg cagcctggtc tgcatgggca      720

gccgaccaag gggactttga gaaaccaagg cagtatcatg agcaggaaga aacacctgag      780

atgatggcag cccgcattga cagagatgtg caaatcttaa accacatttt ggatgacatt      840

gaatttttta tcacaaaact ccaaaaagca gcagaagcat tttctgagct ttctaaaagg      900

aagaaaaaca agaaaggtaa aaggaaagga ccaggagagg gtgttttaac gctgcgggca      960

aaacctccac ctcctgatga atttcttgac tgtttccaaa agtttaaaca cggatttaac     1020

cttctggcca aactgaagtc tcatattcag aatcctagtg ctgcagattt ggttcacttt     1080

ttgtttactc cattaaatat ggtggtgcag gcaacaggag gtcctgaact agccagttca     1140

gtacttagtc ccctattgaa taaggacaca attgatttct taaattatac tgtcaatggt     1200

gatgaacggc agctgtggat gtcattggga ggaacttgga tgaaagccag agcagagtgg     1260

ccaaaagaac agtttattcc accatatgtt ccacgattcc gcaatggctg ggagccccca     1320

atgctgaact ttatgggagc cacaatggaa caagatcttt atcaactggc agaatctgtg     1380

gcaaatgtag cagaacatca gcgcaaacag gaaataaaaa gattatccac agagcattcc     1440

agtgtatcag agtatcatcc agccgatggc tatgcgttca gtagcaacat ttacacaaga     1500

ggatcccacc tggaccaagg ggaagctgct gttgctttta agccaacttc taatcgccat     1560

atagatagaa attatgaacc actcaaaaca caacccaaga aatatgccaa atccaagtat     1620

gactttgtag caaggaacaa cagtgagctc tcggttctaa aggatgatat tttagagata     1680

cttgatgatc ggaagcaatg gtggaaagtt cgaaatgcaa gtggagactc tggatttgtg     1740

ccaaataaca ttttggatat tgtgagacct ccagaatctg gattggggcg tgctgatcca     1800

ccttatactc atactataca gaaacaaagg atggagtatg gcccaagacc agctgatact     1860

ccccctgctc catcacctcc tccaacacca gctcctgttc ctgttcccct tcccccttcc     1920

actccagcac ctgttcctgt gtcaaaggtc ccagcaaata taacacgtca aaacagcagc     1980

tccagtgaca gtggtggcag tatcgtgcga gacagccaga gacacaaaca acttccggtg     2040

gaccgaagga aatctcagat ggaggaagtg caagatgaac tcatccacag actgaccatt     2100

ggtcggagtg ccgctcagaa gaaattccat gtgccacggc agaacgtgcc agttatcaat     2160

atcacttacg actccacacc agaggatgtg aagacgtggt tacagtcaaa gggattcaac     2220

cctgtgactg tcaatagtct tggagtatta aatggtgcac aacttttctc tctcaataag     2280

gatgaactga ggacagtctg ccctgaaggg gcgagagtct atagccaaat cactgtacaa     2340

aaagctgcat tggaggatag cagtggcagc tccgagttac aagaaattat gagaagacga     2400

caggaaaaaa tcagtgctgc cgctagtgat tcaggagtgg aatcttttga tgaaggaagc     2460

agtcactaa                                                             2469


<210>  696
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Asn Gly His Ile Ser Asn His Pro Ser Ser Phe Gly Met Tyr Pro 
1               5                   10                  15      


Ser Gln Met Asn Gly Tyr Gly Ser Ser Pro Thr Phe Ser Gln Thr Asp 
            20                  25                  30          


Arg Glu His Gly Ser Lys Thr Ser Ala Lys Ala Leu Tyr Glu Gln Arg 
        35                  40                  45              


Lys Asn Tyr Ala Arg Asp Ser Val Ser Ser Val Ser Asp Ile Ser Gln 
    50                  55                  60                  


Tyr Arg Val Glu His Leu Thr Thr Phe Val Leu Asp Arg Lys Asp Ala 
65                  70                  75                  80  


Met Ile Thr Val Asp Asp Gly Ile Arg Lys Leu Lys Leu Leu Asp Ala 
                85                  90                  95      


Lys Gly Lys Val Trp Thr Gln Asp Met Ile Leu Gln Val Asp Asp Arg 
            100                 105                 110         


Ala Val Ser Leu Ile Asp Leu Glu Ser Lys Asn Glu Leu Glu Asn Phe 
        115                 120                 125             


Pro Leu Asn Thr Ile Gln His Cys Gln Ala Val Met His Ser Cys Ser 
    130                 135                 140                 


Tyr Asp Ser Val Leu Ala Leu Val Cys Lys Glu Pro Thr Gln Asn Lys 
145                 150                 155                 160 


Pro Asp Leu His Leu Phe Gln Cys Asp Glu Val Lys Ala Asn Leu Ile 
                165                 170                 175     


Ser Glu Asp Ile Glu Ser Ala Ile Ser Asp Ser Lys Gly Gly Lys Gln 
            180                 185                 190         


Lys Arg Arg Pro Asp Ala Leu Arg Met Ile Ser Asn Ala Asp Pro Ser 
        195                 200                 205             


Ile Pro Pro Pro Pro Arg Ala Pro Ala Pro Ala Pro Pro Gly Thr Val 
    210                 215                 220                 


Thr Gln Val Asp Val Arg Ser Arg Val Ala Ala Trp Ser Ala Trp Ala 
225                 230                 235                 240 


Ala Asp Gln Gly Asp Phe Glu Lys Pro Arg Gln Tyr His Glu Gln Glu 
                245                 250                 255     


Glu Thr Pro Glu Met Met Ala Ala Arg Ile Asp Arg Asp Val Gln Ile 
            260                 265                 270         


Leu Asn His Ile Leu Asp Asp Ile Glu Phe Phe Ile Thr Lys Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Ala Phe Ser Glu Leu Ser Lys Arg Lys Lys Asn Lys 
    290                 295                 300                 


Lys Gly Lys Arg Lys Gly Pro Gly Glu Gly Val Leu Thr Leu Arg Ala 
305                 310                 315                 320 


Lys Pro Pro Pro Pro Asp Glu Phe Leu Asp Cys Phe Gln Lys Phe Lys 
                325                 330                 335     


His Gly Phe Asn Leu Leu Ala Lys Leu Lys Ser His Ile Gln Asn Pro 
            340                 345                 350         


Ser Ala Ala Asp Leu Val His Phe Leu Phe Thr Pro Leu Asn Met Val 
        355                 360                 365             


Val Gln Ala Thr Gly Gly Pro Glu Leu Ala Ser Ser Val Leu Ser Pro 
    370                 375                 380                 


Leu Leu Asn Lys Asp Thr Ile Asp Phe Leu Asn Tyr Thr Val Asn Gly 
385                 390                 395                 400 


Asp Glu Arg Gln Leu Trp Met Ser Leu Gly Gly Thr Trp Met Lys Ala 
                405                 410                 415     


Arg Ala Glu Trp Pro Lys Glu Gln Phe Ile Pro Pro Tyr Val Pro Arg 
            420                 425                 430         


Phe Arg Asn Gly Trp Glu Pro Pro Met Leu Asn Phe Met Gly Ala Thr 
        435                 440                 445             


Met Glu Gln Asp Leu Tyr Gln Leu Ala Glu Ser Val Ala Asn Val Ala 
    450                 455                 460                 


Glu His Gln Arg Lys Gln Glu Ile Lys Arg Leu Ser Thr Glu His Ser 
465                 470                 475                 480 


Ser Val Ser Glu Tyr His Pro Ala Asp Gly Tyr Ala Phe Ser Ser Asn 
                485                 490                 495     


Ile Tyr Thr Arg Gly Ser His Leu Asp Gln Gly Glu Ala Ala Val Ala 
            500                 505                 510         


Phe Lys Pro Thr Ser Asn Arg His Ile Asp Arg Asn Tyr Glu Pro Leu 
        515                 520                 525             


Lys Thr Gln Pro Lys Lys Tyr Ala Lys Ser Lys Tyr Asp Phe Val Ala 
    530                 535                 540                 


Arg Asn Asn Ser Glu Leu Ser Val Leu Lys Asp Asp Ile Leu Glu Ile 
545                 550                 555                 560 


Leu Asp Asp Arg Lys Gln Trp Trp Lys Val Arg Asn Ala Ser Gly Asp 
                565                 570                 575     


Ser Gly Phe Val Pro Asn Asn Ile Leu Asp Ile Val Arg Pro Pro Glu 
            580                 585                 590         


Ser Gly Leu Gly Arg Ala Asp Pro Pro Tyr Thr His Thr Ile Gln Lys 
        595                 600                 605             


Gln Arg Met Glu Tyr Gly Pro Arg Pro Ala Asp Thr Pro Pro Ala Pro 
    610                 615                 620                 


Ser Pro Pro Pro Thr Pro Ala Pro Val Pro Val Pro Leu Pro Pro Ser 
625                 630                 635                 640 


Thr Pro Ala Pro Val Pro Val Ser Lys Val Pro Ala Asn Ile Thr Arg 
                645                 650                 655     


Gln Asn Ser Ser Ser Ser Asp Ser Gly Gly Ser Ile Val Arg Asp Ser 
            660                 665                 670         


Gln Arg His Lys Gln Leu Pro Val Asp Arg Arg Lys Ser Gln Met Glu 
        675                 680                 685             


Glu Val Gln Asp Glu Leu Ile His Arg Leu Thr Ile Gly Arg Ser Ala 
    690                 695                 700                 


Ala Gln Lys Lys Phe His Val Pro Arg Gln Asn Val Pro Val Ile Asn 
705                 710                 715                 720 


Ile Thr Tyr Asp Ser Thr Pro Glu Asp Val Lys Thr Trp Leu Gln Ser 
                725                 730                 735     


Lys Gly Phe Asn Pro Val Thr Val Asn Ser Leu Gly Val Leu Asn Gly 
            740                 745                 750         


Ala Gln Leu Phe Ser Leu Asn Lys Asp Glu Leu Arg Thr Val Cys Pro 
        755                 760                 765             


Glu Gly Ala Arg Val Tyr Ser Gln Ile Thr Val Gln Lys Ala Ala Leu 
    770                 775                 780                 


Glu Asp Ser Ser Gly Ser Ser Glu Leu Gln Glu Ile Met Arg Arg Arg 
785                 790                 795                 800 


Gln Glu Lys Ile Ser Ala Ala Ala Ser Asp Ser Gly Val Glu Ser Phe 
                805                 810                 815     


Asp Glu Gly Ser Ser His 
            820         


<210>  697
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  697
atggaccctg ggaaggacaa agagggggtg ccccagccct cagggccgcc agcaaggaag       60

aaatttgtga tacccctcga cgaggatgag gtccctcctg gagtggccaa gcccttattc      120

cgatctacac agagccttcc cactgtggac acctcggccc aggcggcccc tcagacctac      180

gccgaatatg ccatctcaca gcctctggaa ggggctgggg ccacgtgccc cacagggtca      240

gagcccctgg caggagagac gcccaaccag gccctgaaac ccggggcaaa atccaacagc      300

atcattgtga gccctcggca gaggggcaat cccgtactga agttcgtgcg caatgtgccc      360

tgggaatttg gcgacgtaat tcccgactat gtgctgggcc agagcacctg tgccctgttc      420

ctcagcctcc gctaccacaa cctgcaccca gactacatcc atgggcggct gcagagcctg      480

gggaagaact tcgccttgcg ggtcctgctt gtccaggtgg atgtgaaaga tccccagcag      540

gccctcaagg agctggctaa gatgtgtatc ctggccgact gcacattgat cctcgcctgg      600

agccccgagg aagctgggcg gtacctggag acctacaagg cctatgagca gaaaccagcg      660

gacctcctga tggagaagct agagcaggac ttcgtctccc gggtgactga atgtctgacc      720

accgtgaagt cagtcaacaa aacggacagt cagaccctcc tgaccacatt tggatctctg      780

gaacagctca tcgccgcatc aagagaagat ctggccttat gcccaggcct gggccctcag      840

aaagcccgga ggctgtttga tgtcctgcac gagcccttct tgaaagtacc ctga            894


<210>  698
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 


Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     


Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         


Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 
        275                 280                 285             


Leu His Glu Pro Phe Leu Lys Val Pro 
    290                 295         


<210>  699
<211>  2241
<212>  DNA
<213>  Homo sapiens

<400>  699
atgggccaga ctgggaagaa atctgagaag ggaccagttt gttggcggaa gcgtgtaaaa       60

tcagagtaca tgcgactgag acagctcaag aggttcagac gagctgatga agtaaagagt      120

atgtttagtt ccaatcgtca gaaaattttg gaaagaacgg aaatcttaaa ccaagaatgg      180

aaacagcgaa ggatacagcc tgtgcacatc ctgacttctg tgagctcatt gcgcgggact      240

agggagtgtt cggtgaccag tgacttggat tttccaacac aagtcatccc attaaagact      300

ctgaatgcag ttgcttcagt acccataatg tattcttggt ctcccctaca gcagaatttt      360

atggtggaag atgaaactgt tttacataac attccttata tgggagatga agttttagat      420

caggatggta ctttcattga agaactaata aaaaattatg atgggaaagt acacggggat      480

agagaatgtg ggtttataaa tgatgaaatt tttgtggagt tggtgaatgc ccttggtcaa      540

tataatgatg atgacgatga tgatgatgga gacgatcctg aagaaagaga agaaaagcag      600

aaagatctgg aggatcaccg agatgataaa gaaagccgcc cacctcggaa atttccttct      660

gataaaattt ttgaagccat ttcctcaatg tttccagata agggcacagc agaagaacta      720

aaggaaaaat ataaagaact caccgaacag cagctcccag gcgcacttcc tcctgaatgt      780

acccccaaca tagatggacc aaatgctaaa tctgttcaga gagagcaaag cttacactcc      840

tttcatacgc ttttctgtag gcgatgtttt aaatatgact gcttcctaca tccttttcat      900

gcaacaccca acacttataa gcggaagaac acagaaacag ctctagacaa caaaccttgt      960

ggaccacagt gttaccagca tttggaggga gcaaaggagt ttgctgctgc tctcaccgct     1020

gagcggataa agaccccacc aaaacgtcca ggaggccgca gaagaggacg gcttcccaat     1080

aacagtagca ggcccagcac ccccaccatt aatgtgctgg aatcaaagga tacagacagt     1140

gatagggaag cagggactga aacgggggga gagaacaatg ataaagaaga agaagagaag     1200

aaagatgaaa cttcgagctc ctctgaagca aattctcggt gtcaaacacc aataaagatg     1260

aagccaaata ttgaacctcc tgagaatgtg gagtggagtg gtgctgaagc ctcaatgttt     1320

agagtcctca ttggcactta ctatgacaat ttctgtgcca ttgctaggtt aattgggacc     1380

aaaacatgta gacaggtgta tgagtttaga gtcaaagaat ctagcatcat agctccagct     1440

cccgctgagg atgtggatac tcctccaagg aaaaagaaga ggaaacaccg gttgtgggct     1500

gcacactgca gaaagataca gctgaaaaag gacggctcct ctaaccatgt ttacaactat     1560

caaccctgtg atcatccacg gcagccttgt gacagttcgt gcccttgtgt gatagcacaa     1620

aatttttgtg aaaagttttg tcaatgtagt tcagagtgtc aaaaccgctt tccgggatgc     1680

cgctgcaaag cacagtgcaa caccaagcag tgcccgtgct acctggctgt ccgagagtgt     1740

gaccctgacc tctgtcttac ttgtggagcc gctgaccatt gggacagtaa aaatgtgtcc     1800

tgcaagaact gcagtattca gcggggctcc aaaaagcatc tattgctggc accatctgac     1860

gtggcaggct gggggatttt tatcaaagat cctgtgcaga aaaatgaatt catctcagaa     1920

tactgtggag agattatttc tcaagatgaa gctgacagaa gagggaaagt gtatgataaa     1980

tacatgtgca gctttctgtt caacttgaac aatgattttg tggtggatgc aacccgcaag     2040

ggtaacaaaa ttcgttttgc aaatcattcg gtaaatccaa actgctatgc aaaagttatg     2100

atggttaacg gtgatcacag gataggtatt tttgccaaga gagccatcca gactggcgaa     2160

gagctgtttt ttgattacag atacagccag gctgatgccc tgaagtatgt cggcatcgaa     2220

agagaaatgg aaatcccttg a                                               2241


<210>  700
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  701
<211>  7944
<212>  DNA
<213>  Homo sapiens

<400>  701
atgagtagct cccactctcg ggcgggccag agcgcagcag gcgcggctcc gggcggcggc       60

gtcgacacgc gggacgccga gatgccggcc accgagaagg acctggcgga ggacgcgccg      120

tggaagaaga tccagcagaa cactttcacg cgctggtgca acgagcacct gaagtgcgtg      180

agcaagcgca tcgccaacct gcagacggac ctgagcgacg ggctgcggct tatcgcgctg      240

ttggaggtgc tcagccagaa gaagatgcac cgcaagcaca accagcggcc cactttccgc      300

caaatgcagc ttgagaacgt gtcggtggcg ctcgagttcc tggaccgcga gagcatcaaa      360

ctggtgtcca tcgacagcaa ggccatcgtg gacgggaacc tgaagctgat cctgggcctc      420

atctggaccc tgatcctgca ctactccatc tccatgccca tgtgggacga ggaggaggat      480

gaggaggcca agaagcagac ccccaagcag aggctcctgg gctggatcca gaacaagctg      540

ccgcagctgc ccatcaccaa cttcagccgg gactggcaga gcggccgggc cctgggcgcc      600

ctggtggaca gctgtgcccc gggcctgtgt cctgactggg actcttggga cgccagcaag      660

cccgttacca atgcgcgaga ggccatgcag caggcggatg actggctggg catcccccag      720

gtgatcaccc ccgaggagat tgtggacccc aacgtggacg agcactctgt catgacctac      780

ctgtcccagt tccccaaggc caagctgaag ccaggggctc ccttgcgccc caaactgaac      840

ccgaagaaag cccgtgccta cgggccaggc atcgagccca caggcaacat ggtgaagaag      900

cgggcagagt tcactgtgga gaccagaagt gctggccagg gagaggtgct ggtgtacgtg      960

gaggacccgg ccggacacca ggaggaggca aaagtgaccg ccaataacga caagaaccgc     1020

accttctccg tctggtacgt ccccgaggtg acggggactc ataaggttac tgtgctcttt     1080

gctggccagc acatcgccaa gagccccttc gaggtgtacg tggataagtc acagggtgac     1140

gccagcaaag tgacagccca aggtcccggc ctggagccca gtggcaacat cgccaacaag     1200

accacctact ttgagatctt tacggcagga gctggcacgg gcgaggtcga ggttgtgatc     1260

caggacccca tgggacagaa gggcacggta gagcctcagc tggaggcccg gggcgacagc     1320

acataccgct gcagctacca gcccaccatg gagggcgtcc acaccgtgca cgtcacgttt     1380

gccggcgtgc ccatccctcg cagcccctac actgtcactg ttggccaagc ctgtaacccg     1440

agtgcctgcc gggcggttgg ccggggcctc cagcccaagg gtgtgcgggt gaaggagaca     1500

gctgacttca aggtgtacac aaagggcgct ggcagtgggg agctgaaggt caccgtgaag     1560

ggccccaagg gagaggagcg cgtgaagcag aaggacctgg gggatggcgt gtatggcttc     1620

gagtattacc ccatggtccc tggaacctat atcgtcacca tcacgtgggg tggtcagaac     1680

atcgggcgca gtcccttcga agtgaaggtg ggcaccgagt gtggcaatca gaaggtacgg     1740

gcctggggcc ctgggctgga gggcggcgtc gttggcaagt cagcagactt tgtggtggag     1800

gctatcgggg acgacgtggg cacgctgggc ttctcggtgg aagggccatc gcaggctaag     1860

atcgaatgtg acgacaaggg cgacggctcc tgtgatgtgc gctactggcc gcaggaggct     1920

ggcgagtatg ccgttcacgt gctgtgcaac agcgaagaca tccgcctcag ccccttcatg     1980

gctgacatcc gtgacgcgcc ccaggacttc cacccagaca gggtgaaggc acgtgggcct     2040

ggattggaga agacaggtgt ggccgtcaac aagccagcag agttcacagt ggatgccaag     2100

cacggtggca aggccccact tcgggtccaa gtccaggaca atgaaggctg ccctgtggag     2160

gcgttggtca aggacaacgg caatggcact tacagctgct cctacgtgcc caggaagccg     2220

gtgaagcaca cagccatggt gtcctgggga ggcgtcagca tccccaacag ccccttcagg     2280

gtgaatgtgg gagctggcag ccaccccaac aaggtcaaag tatacggccc cggagtagcc     2340

aagacagggc tcaaggccca cgagcccacc tacttcactg tggactgcgc cgaggctggc     2400

cagggggacg tcagcatcgg catcaagtgt gcccctggag tggtaggccc cgccgaagct     2460

gacatcgact tcgacatcat ccgcaatgac aatgacacct tcacggtcaa gtacacgccc     2520

cggggggctg gcagctacac cattatggtc ctctttgctg accaggccac gcccaccagc     2580

cccatccgag tcaaggtgga gccctctcat gacgccagta aggtgaaggc cgagggccct     2640

ggcctcagtc gcactggtgt cgagcttggc aagcccaccc acttcacagt aaatgccaaa     2700

gctgctggca aaggcaagct ggacgtccag ttctcaggac tcaccaaggg ggatgcagtg     2760

cgagatgtgg acatcatcga ccaccatgac aacacctaca cagtcaagta cacgcctgtc     2820

cagcagggtc cagtaggcgt caatgtcact tatggagggg atcccatccc taagagccct     2880

ttctcagtgg cagtatctcc aagcctggac ctcagcaaga tcaaggtgtc tggcctggga     2940

gagaaggtgg acgttggcaa agaccaggag ttcacagtca aatcaaaggg tgctggtggt     3000

caaggcaaag tggcatccaa gattgtgggc ccctcgggtg cagcggtgcc ctgcaaggtg     3060

gagccaggcc tgggggctga caacagtgtg gtgcgcttcc tgccccgtga ggaagggccc     3120

tatgaggtgg aggtgaccta tgacggcgtg cccgtgcctg gcagcccctt tcctctggaa     3180

gctgtggccc ccaccaagcc tagcaaggtg aaggcgtttg ggccggggct gcagggaggc     3240

agtgcgggct cccccgcccg cttcaccatc gacaccaagg gcgccggcac aggtggcctg     3300

ggcctgacgg tggagggccc ctgtgaggcg cagctcgagt gcttggacaa tggggatggc     3360

acatgttccg tgtcctacgt gcccaccgag cccggggact acaacatcaa catcctcttc     3420

gctgacaccc acatccctgg ctccccattc aaggcccacg tggttccctg ctttgacgca     3480

tccaaagtca agtgctcagg ccccgggctg gagcgggcca ccgctgggga ggtgggccaa     3540

ttccaagtgg actgctcgag cgcgggcagc gcggagctga ccattgagat ctgctcggag     3600

gcggggcttc cggccgaggt gtacatccag gaccacggtg atggcacgca caccattacc     3660

tacattcccc tctgccccgg ggcctacacc gtcaccatca agtacggcgg ccagcccgtg     3720

cccaacttcc ccagcaagct gcaggtggaa cctgcggtgg acacttccgg tgtccagtgc     3780

tatgggcctg gtattgaggg ccagggtgtc ttccgtgagg ccaccactga gttcagtgtg     3840

gacgcccggg ctctgacaca gaccggaggg ccgcacgtca aggcccgtgt ggccaacccc     3900

tcaggcaacc tgacggagac ctacgttcag gaccgtggcg atggcatgta caaagtggag     3960

tacacgcctt acgaggaggg actgcactcc gtggacgtga cctatgacgg cagtcccgtg     4020

cccagcagcc ccttccaggt gcccgtgacc gagggctgcg acccctcccg ggtgcgtgtc     4080

cacgggccag gcatccaaag tggcaccacc aacaagccca acaagttcac tgtggagacc     4140

aggggagctg gcacgggcgg cctgggcctg gctgtagagg gcccctccga ggccaagatg     4200

tcctgcatgg ataacaagga cggcagctgc tcggtcgagt acatccctta tgaggctggc     4260

acctacagcc tcaacgtcac ctatggtggc catcaagtgc caggcagtcc tttcaaggtc     4320

cctgtgcatg atgtgacaga tgcgtccaag gtcaagtgct ctgggcccgg cctgagccca     4380

ggcatggttc gtgccaacct ccctcagtcc ttccaggtgg acacaagcaa ggctggtgtg     4440

gccccattgc aggtcaaagt gcaagggccc aaaggcctgg tggagccagt ggacgtggta     4500

gacaacgctg atggcaccca gaccgtcaat tatgtgccca gccgagaagg gccctacagc     4560

atctcagtac tgtatggaga tgaagaggta ccccggagcc ccttcaaggt caaggtgctg     4620

cctactcatg atgccagcaa ggtgaaggcc agtggccccg ggctcaacac cactggcgtg     4680

cctgccagcc tgcccgtgga gttcaccatc gatgcaaagg acgccgggga gggcctgctg     4740

gctgtccaga tcacggatcc cgaaggcaag ccgaagaaga cacacatcca agacaaccat     4800

gacggcacgt atacagtggc ctacgtgcca gacgtgacag gtcgctacac catcctcatc     4860

aagtacggtg gtgacgagat ccccttctcc ccgtaccgcg tgcgtgccgt gcccaccggg     4920

gacgccagca agtgcactgt cacagtgtca atcggaggtc acgggctagg tgctggcatc     4980

ggccccacca ttcagattgg ggaggagacg gtgatcactg tggacactaa ggcggcaggc     5040

aaaggcaaag tgacgtgcac cgtgtgcacg cctgatggct cagaggtgga tgtggacgtg     5100

gtggagaatg aggacggcac tttcgacatc ttctacacgg ccccccagcc gggcaaatac     5160

gtcatctgtg tgcgctttgg tggcgagcac gtgcccaaca gccccttcca agtgacggct     5220

ctggctgggg accagccctc ggtgcagccc cctctacggt ctcagcagct ggccccacag     5280

tacacctacg cccagggcgg ccagcagact tgggccccgg agaggcccct ggtgggtgtc     5340

aatgggctgg atgtgaccag cctgaggccc tttgaccttg tcatcccctt caccatcaag     5400

aagggcgaga tcacagggga ggttcggatg ccctcaggca aggtggcgca gcccaccatc     5460

actgacaaca aagacggcac cgtgaccgtg cggtatgcac ccagcgaggc tggcctgcac     5520

gagatggaca tccgctatga caacatgcac atcccaggaa gccccttgca gttctatgtg     5580

gattacgtca actgtggcca tgtcactgcc tatgggcctg gcctcaccca tggagtagtg     5640

aacaagcctg ccaccttcac cgtcaacacc aaggatgcag gagagggggg cctgtctctg     5700

gccattgagg gcccgtccaa agcagaaatc agctgcactg acaaccagga tgggacatgc     5760

agcgtgtcct acctgcctgt gctgccgggg gactacagca ttctagtcaa gtacaatgaa     5820

cagcacgtcc caggcagccc cttcactgct cgggtcacag gtgacgactc catgcgtatg     5880

tcccacctaa aggtcggctc tgctgccgac atccccatca acatctcaga gacggatctc     5940

agcctgctga cggccactgt ggtcccgccc tcgggccggg aggagccctg tttgctgaag     6000

cggctgcgta atggccacgt ggggatttca ttcgtgccca aggagacggg ggagcacctg     6060

gtgcatgtga agaaaaatgg ccagcacgtg gccagcagcc ccatcccggt ggtgatcagc     6120

cagtcggaaa ttggggatgc cagtcgtgtt cgggtctctg gtcagggcct tcacgaaggc     6180

cacacctttg agcctgcaga gtttatcatt gatacccgcg atgcaggcta tggtgggctc     6240

agcctgtcca ttgagggccc cagcaaggtg gacatcaaca cagaggacct ggaggacggg     6300

acgtgcaggg tcacctactg ccccacagag ccaggcaact acatcatcaa catcaagttt     6360

gccgaccagc acgtgcctgg cagccccttc tctgtgaagg tgacaggcga gggccgggtg     6420

aaagagagca tcacccgcag gcgtcgggct ccttcagtgg ccaacgttgg tagtcattgt     6480

gacctcagcc tgaaaatccc tgaaattagc atccaggata tgacagccca ggtgaccagc     6540

ccatcgggca agacccatga ggccgagatc gtggaagggg agaaccacac ctactgcatc     6600

cgctttgttc ccgctgagat gggcacacac acagtcagcg tcaagtacaa gggccagcac     6660

gtgcctggga gccccttcca gttcaccgtg gggcccctag gggaaggggg agcccacaag     6720

gtccgagctg ggggccctgg cctggagaga gctgaagctg gagtgccagc cgaattcagt     6780

atctggaccc gggaagctgg tgctggaggc ctggccattg ctgtcgaggg ccccagcaag     6840

gctgagatct cttttgagga ccgcaaggac ggctcctgtg gtgtggctta tgtggtccag     6900

gagccaggtg actacgaagt ctcagtcaag ttcaacgagg aacacattcc cgacagcccc     6960

ttcgtggtgc ctgtggcttc tccgtctggc gacgcccgcc gcctcactgt ttctagcctt     7020

caggagtcag ggctaaaggt caaccagcca gcctcttttg cagtcagcct gaacggggcc     7080

aagggggcga tcgatgccaa ggtgcacagc ccctcaggag ccctggagga gtgctatgtc     7140

acagaaattg accaagataa gtatgctgtg cgcttcatcc ctcgggagaa tggcgtttac     7200

ctgattgacg tcaagttcaa cggtacccac atccctggaa gccccttcaa gatccgagtt     7260

ggggagcctg ggcatggagg ggacccaggc ttggtgtctg cttacggagc aggtctggaa     7320

ggcggtgtca cagggaaccc agctgagttc gtcgtgaaca cgagcaatgc gggagctggt     7380

gccctgtcgg tgaccattga cggcccctcc aaggtgaaga tggattgcca ggagtgccct     7440

gagggctacc gcgtcaccta tacccccatg gcacctggca gctacctcat ctccatcaag     7500

tacggcggcc cctaccacat tgggggcagc cccttcaagg ccaaagtcac aggcccccgt     7560

ctcgtcagca accacagcct ccacgagaca tcatcagtgt ttgtagactc tctgaccaag     7620

gccacctgtg ccccccagca tggggccccg ggtcctgggc ctgctgacgc cagcaaggtg     7680

gtggccaagg gcctggggct gagcaaggcc tacgtaggcc agaagagcag cttcacagta     7740

gactgcagca aagcaggcaa caacatgctg ctggtggggg ttcatggccc aaggaccccc     7800

tgcgaggaga tcctggtgaa gcacgtgggc agccggctct acagcgtgtc ctacctgctc     7860

aaggacaagg gggagtacac actggtggtc aaatgggggc acgagcacat cccaggcagc     7920

ccctaccgcg ttgtggtgcc ctga                                            7944


<210>  702
<211>  2647
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly His Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  703
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  703
atgacgttgc agccccgctg cgaggacgta gagacggccg agggggtagc tttaactgtg       60

acgggtgtcg cccaggtgaa gatcatgacg gagaaggaac tcctggccgt ggcttgtgag      120

cagtttctgg gtaagaatgt gcaggacatc aaaaacgtcg tcctgcagac cctggaggga      180

catctgcgct ccatcctcgg gaccctgaca gtggagcaga tttatcagga ccgggaccag      240

tttgccaagc tggtgcggga ggtggcagcc cctgatgttg gccgcatggg cattgagatc      300

ctcagcttca ccatcaagga cgtgtatgac aaagtggact atctgagctc cctgggcaag      360

acgcagactg ccgtggtgca gagagatgct gacattggcg tggccgaggc tgaacgggac      420

gcaggcatcc gggaagctga gtgcaagaag gagatgctgg atgtgaagtt catggcagac      480

accaagattg ctgactctaa gcgagccttc gagctgcaaa agtcagcctt cagtgaggag      540

gttaacatca agacagctga ggcccagttg gcctatgagc tgcagggggc ccgtgaacag      600

cagaagatcc ggcaggaaga gattgagatt gaggttgtgc agcgcaagaa acagattgcc      660

gtggaggcac aggagatcct gcgtacggac aaggagctca tcgctacagt gcgccggcct      720

gccgaggccg aggcccaccg catccagcag attgccgagg gtgaaaaggt gaagcaggtc      780

ctcttggcac aggcagaggc tgagaagatc cgcaaaatcg gggaggcgga agcggcagtc      840

atcgaggcga tgggcaaggc agaggctgag cggatgaagc tcaaggcaga agcctaccag      900

aaatacgggg atgcagccaa gatggccttg gtgctagagg ccctgcccca gattgctgcc      960

aaaatcgctg ccccacttac caaggtcgat gagattgtgg tcctcagtgg agacaacagt     1020

aaggtcacat cagaagtgaa ccgactgctg gccgagctgc ctgcctctgt gcatgccctc     1080

acaggcgtgg acctgtctaa gatacccctg atcaagaagg ccactggtgt gcaggtgtga     1140


<210>  704
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly Val 
1               5                   10                  15      


Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu Lys 
            20                  25                  30          


Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val Gln 
        35                  40                  45              


Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg Ser 
    50                  55                  60                  


Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp Gln 
65                  70                  75                  80  


Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg Met 
                85                  90                  95      


Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys Val 
            100                 105                 110         


Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln Arg 
        115                 120                 125             


Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile Arg 
    130                 135                 140                 


Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala Asp 
145                 150                 155                 160 


Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser Ala 
                165                 170                 175     


Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala Tyr 
            180                 185                 190         


Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu Ile 
        195                 200                 205             


Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala Gln 
    210                 215                 220                 


Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg Pro 
225                 230                 235                 240 


Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu Lys 
                245                 250                 255     


Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg Lys 
            260                 265                 270         


Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala Glu 
        275                 280                 285             


Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly Asp 
    290                 295                 300                 


Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala Ala 
305                 310                 315                 320 


Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu Ser 
                325                 330                 335     


Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala Glu 
            340                 345                 350         


Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys Ile 
        355                 360                 365             


Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
    370                 375                 


<210>  705
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  705
atggcggcag ggaccagcag ttactgggaa gatctcagga aacaggctcg acagctggaa       60

aatgaacttg acctgaaact agtttccttc agcaaactat gtacaagtta cagtcatagc      120

agtacccgag atggaagacg cgacaggtat agttctgata caacacccct tttaaatgga      180

tcaagccaag acagaatgtt tgagacaatg gcgattgaga ttgaacaact tttggcaagg      240

cttacagggg taaatgataa aatggcagaa tataccaaca gtgcaggtgt cccctccttg      300

aatgcagccc tgatgcatac attacagcgg catagagaca tattgcagga ttatacacat      360

gaattccata aaaccaaagc aaactttatg gcaatacggg aaagggagaa tcttatggga      420

tcagtacgaa aagatattga gtcatataaa agtgggtctg gagtaaacaa cagaagaact      480

gagctatttt tgaaagaaca tgaccacctt cgaaactcag atcgtctgat agaagagaca      540

ataagcattg ctatggcaac aaaagaaaat atgacttcac agagaggaat gttgaagtca      600

attcacagca aaatgaacac tttggccaat cgttttcctg ctgtaaacag cctgatccag      660

aggatcaacc tgaggaagcg gcgggactcg ctcatcctag ggggtgttat tgggatctgt      720

accatcctgt tgctgctgta tgcgttccat tga                                   753


<210>  706
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
1               5                   10                  15      


Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
            20                  25                  30          


Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
        35                  40                  45              


Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp 
    50                  55                  60                  


Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg 
65                  70                  75                  80  


Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly 
                85                  90                  95      


Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg 
            100                 105                 110         


Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn 
        115                 120                 125             


Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys 
    130                 135                 140                 


Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr 
145                 150                 155                 160 


Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu 
                165                 170                 175     


Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr 
            180                 185                 190         


Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu 
        195                 200                 205             


Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu 
    210                 215                 220                 


Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys 
225                 230                 235                 240 


Thr Ile Leu Leu Leu Leu Tyr Ala Phe His 
                245                 250 


<210>  707
<211>  1599
<212>  DNA
<213>  Homo sapiens

<400>  707
atggagctgg atctgtctcc acctcatctt agcagctctc cggaagacct ttgcccagcc       60

cctgggaccc ctcctgggac tccccggccc cctgataccc ctctgcctga ggaggtaaag      120

aggtcccagc ctctcctcat cccaaccacc ggcaggaaac ttcgagagga ggagaggcgt      180

gccacctccc tcccctctat ccccaacccc ttccctgagc tctgcagtcc tccctcacag      240

agcccaattc tcgggggccc ctccagtgca agggggctgc tcccccgcga tgccagccgc      300

ccccatgtag taaaggtgta cagtgaggat ggggcctgca ggtctgtgga ggtggcagca      360

ggtgccacag ctcgccacgt gtgtgaaatg ctggtgcagc gagctcacgc cttgagcgac      420

gagacctggg ggctggtgga gtgccacccc cacctagcac tggagcgggg tttggaggac      480

cacgagtccg tggtggaagt gcaggctgcc tggcccgtgg gcggagatag ccgcttcgtc      540

ttccggaaaa acttcgccaa gtacgaactg ttcaagagct ccccacactc cctgttccca      600

gaaaaaatgg tctccagctg tctcgatgca cacactggta tatcccatga agacctcatc      660

cagaacttcc tgaatgctgg cagctttcct gagatccagg gctttctgca gctgcggggt      720

tcaggacgga agctttggaa acgctttttc tgcttcttgc gccgatctgg cctctattac      780

tccaccaagg gcacctctaa ggatccgagg cacctgcagt acgtggcaga tgtgaacgag      840

tccaacgtgt acgtggtgac gcagggccgc aagctctacg ggatgcccac tgacttcggt      900

ttctgtgtca agcccaacaa gcttcgaaat ggccacaagg ggcttcggat cttctgcagt      960

gaagatgagc agagccgcac ctgctggctg gctgccttcc gcctcttcaa gtacggggtg     1020

cagctgtaca agaattacca gcaggcacag tctcgccatc tgcatccatc ttgtttgggc     1080

tccccaccct tgagaagtgc ctcagataat accctggtgg ccatggactt ctctggccat     1140

gctgggcgtg tcattgagaa cccccgggag gctctgagtg tggccctgga ggaggcccag     1200

gcctggagga agaagacaaa ccaccgcctc agcctgccca tgccagcctc cggcacgagc     1260

ctcagtgcag ccatccaccg cacccaactc tggttccacg ggcgcatttc ccgtgaggag     1320

agccagcggc ttattggaca gcagggcttg gtagacggcc tgttcctggt ccgggagagt     1380

cagcggaacc cccagggctt tgtcctctct ttgtgccacc tgcagaaagt gaagcattat     1440

ctcatcctgc cgagcgagga ggagggccgc ctgtacttca gcatggatga tggccagacc     1500

cgcttcactg acctgctgca gctcgtggag ttccaccagc tgaaccgcgg catcctgccg     1560

tgcttgctgc gccattgctg cacgcgggtg gccctctga                            1599


<210>  708
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Glu Leu Asp Leu Ser Pro Pro His Leu Ser Ser Ser Pro Glu Asp 
1               5                   10                  15      


Leu Cys Pro Ala Pro Gly Thr Pro Pro Gly Thr Pro Arg Pro Pro Asp 
            20                  25                  30          


Thr Pro Leu Pro Glu Glu Val Lys Arg Ser Gln Pro Leu Leu Ile Pro 
        35                  40                  45              


Thr Thr Gly Arg Lys Leu Arg Glu Glu Glu Arg Arg Ala Thr Ser Leu 
    50                  55                  60                  


Pro Ser Ile Pro Asn Pro Phe Pro Glu Leu Cys Ser Pro Pro Ser Gln 
65                  70                  75                  80  


Ser Pro Ile Leu Gly Gly Pro Ser Ser Ala Arg Gly Leu Leu Pro Arg 
                85                  90                  95      


Asp Ala Ser Arg Pro His Val Val Lys Val Tyr Ser Glu Asp Gly Ala 
            100                 105                 110         


Cys Arg Ser Val Glu Val Ala Ala Gly Ala Thr Ala Arg His Val Cys 
        115                 120                 125             


Glu Met Leu Val Gln Arg Ala His Ala Leu Ser Asp Glu Thr Trp Gly 
    130                 135                 140                 


Leu Val Glu Cys His Pro His Leu Ala Leu Glu Arg Gly Leu Glu Asp 
145                 150                 155                 160 


His Glu Ser Val Val Glu Val Gln Ala Ala Trp Pro Val Gly Gly Asp 
                165                 170                 175     


Ser Arg Phe Val Phe Arg Lys Asn Phe Ala Lys Tyr Glu Leu Phe Lys 
            180                 185                 190         


Ser Ser Pro His Ser Leu Phe Pro Glu Lys Met Val Ser Ser Cys Leu 
        195                 200                 205             


Asp Ala His Thr Gly Ile Ser His Glu Asp Leu Ile Gln Asn Phe Leu 
    210                 215                 220                 


Asn Ala Gly Ser Phe Pro Glu Ile Gln Gly Phe Leu Gln Leu Arg Gly 
225                 230                 235                 240 


Ser Gly Arg Lys Leu Trp Lys Arg Phe Phe Cys Phe Leu Arg Arg Ser 
                245                 250                 255     


Gly Leu Tyr Tyr Ser Thr Lys Gly Thr Ser Lys Asp Pro Arg His Leu 
            260                 265                 270         


Gln Tyr Val Ala Asp Val Asn Glu Ser Asn Val Tyr Val Val Thr Gln 
        275                 280                 285             


Gly Arg Lys Leu Tyr Gly Met Pro Thr Asp Phe Gly Phe Cys Val Lys 
    290                 295                 300                 


Pro Asn Lys Leu Arg Asn Gly His Lys Gly Leu Arg Ile Phe Cys Ser 
305                 310                 315                 320 


Glu Asp Glu Gln Ser Arg Thr Cys Trp Leu Ala Ala Phe Arg Leu Phe 
                325                 330                 335     


Lys Tyr Gly Val Gln Leu Tyr Lys Asn Tyr Gln Gln Ala Gln Ser Arg 
            340                 345                 350         


His Leu His Pro Ser Cys Leu Gly Ser Pro Pro Leu Arg Ser Ala Ser 
        355                 360                 365             


Asp Asn Thr Leu Val Ala Met Asp Phe Ser Gly His Ala Gly Arg Val 
    370                 375                 380                 


Ile Glu Asn Pro Arg Glu Ala Leu Ser Val Ala Leu Glu Glu Ala Gln 
385                 390                 395                 400 


Ala Trp Arg Lys Lys Thr Asn His Arg Leu Ser Leu Pro Met Pro Ala 
                405                 410                 415     


Ser Gly Thr Ser Leu Ser Ala Ala Ile His Arg Thr Gln Leu Trp Phe 
            420                 425                 430         


His Gly Arg Ile Ser Arg Glu Glu Ser Gln Arg Leu Ile Gly Gln Gln 
        435                 440                 445             


Gly Leu Val Asp Gly Leu Phe Leu Val Arg Glu Ser Gln Arg Asn Pro 
    450                 455                 460                 


Gln Gly Phe Val Leu Ser Leu Cys His Leu Gln Lys Val Lys His Tyr 
465                 470                 475                 480 


Leu Ile Leu Pro Ser Glu Glu Glu Gly Arg Leu Tyr Phe Ser Met Asp 
                485                 490                 495     


Asp Gly Gln Thr Arg Phe Thr Asp Leu Leu Gln Leu Val Glu Phe His 
            500                 505                 510         


Gln Leu Asn Arg Gly Ile Leu Pro Cys Leu Leu Arg His Cys Cys Thr 
        515                 520                 525             


Arg Val Ala Leu 
    530         


<210>  709
<211>  2349
<212>  DNA
<213>  Homo sapiens

<400>  709
atggctccgc accgccccgc gcccgcgctg ctttgcgcgc tgtccctggc gctgtgcgcg       60

ctgtcgctgc ccgtccgcgc ggccactgcg tcgcgggggg cgtcccaggc gggggcgccc      120

caggggcggg tgcccgaggc gcggcccaac agcatggtgg tggaacaccc cgagttcctc      180

aaggcaggga aggagcctgg cctgcagatc tggcgtgtgg agaagttcga tctggtgccc      240

gtgcccacca acctttatgg agacttcttc acgggcgacg cctacgtcat cctgaagaca      300

gtgcagctga ggaacggaaa tctgcagtat gacctccact actggctggg caatgagtgc      360

agccaggatg agagcggggc ggccgccatc tttaccgtgc agctggatga ctacctgaac      420

ggccgggccg tgcagcaccg tgaggtccag ggcttcgagt cggccacctt cctaggctac      480

ttcaagtctg gcctgaagta caagaaagga ggtgtggcat caggattcaa gcacgtggta      540

cccaacgagg tggtggtgca gagactcttc caggtcaaag ggcggcgtgt ggtccgtgcc      600

accgaggtac ctgtgtcctg ggagagcttc aacaatggcg actgcttcat cctggacctg      660

ggcaacaaca tccaccagtg gtgtggttcc aacagcaatc ggtatgaaag actgaaggcc      720

acacaggtgt ccaagggcat ccgggacaac gagcggagtg gccgggcccg agtgcacgtg      780

tctgaggagg gcactgagcc cgaggcgatg ctccaggtgc tgggccccaa gccggctctg      840

cctgcaggta ccgaggacac cgccaaggag gatgcggcca accgcaagct ggccaagctc      900

tacaaggtct ccaatggtgc agggaccatg tccgtctccc tcgtggctga tgagaacccc      960

ttcgcccagg gggccctgaa gtcagaggac tgcttcatcc tggaccacgg caaagatggg     1020

aaaatctttg tctggaaagg caagcaggca aacacggagg agaggaaggc tgccctcaaa     1080

acagcctctg acttcatcac caagatggac taccccaagc agactcaggt ctcggtcctt     1140

cctgagggcg gtgagacccc actgttcaag cagttcttca agaactggcg ggacccagac     1200

cagacagatg gcctgggctt gtcctacctt tccagccata tcgccaacgt ggagcgggtg     1260

cccttcgacg ccgccaccct gcacacctcc actgccatgg ccgcccagca cggcatggat     1320

gacgatggca caggccagaa acagatctgg agaatcgaag gttccaacaa ggtgcccgtg     1380

gaccctgcca catatggaca gttctatgga ggcgacagct acatcattct gtacaactac     1440

cgccatggtg gccgccaggg gcagataatc tataactggc agggtgccca gtctacccag     1500

gatgaggtcg ctgcatctgc catcctgact gctcagctgg atgaggagct gggaggtacc     1560

cctgtccaga gccgtgtggt ccaaggcaag gagcccgccc acctcatgag cctgtttggt     1620

gggaagccca tgatcatcta caagggcggc acctcccgcg agggcgggca gacagcccct     1680

gccagcaccc gcctcttcca ggtccgcgcc aacagcgctg gagccacccg ggctgttgag     1740

gtattgccta aggctggtgc actgaactcc aacgatgcct ttgttctgaa aaccccctca     1800

gccgcctacc tgtgggtggg tacaggagcc agcgaggcag agaagacggg ggcccaggag     1860

ctgctcaggg tgctgcgggc ccaacctgtg caggtggcag aaggcagcga gccagatggc     1920

ttctgggagg ccctgggcgg gaaggctgcc taccgcacat ccccacggct gaaggacaag     1980

aagatggatg cccatcctcc tcgcctcttt gcctgctcca acaagattgg acgttttgtg     2040

atcgaagagg ttcctggtga gctcatgcag gaagacctgg caacggatga cgtcatgctt     2100

ctggacacct gggaccaggt ctttgtctgg gttggaaagg attctcaaga agaagaaaag     2160

acagaagcct tgacttctgc taagcggtac atcgagacgg acccagccaa tcgggatcgg     2220

cggacgccca tcaccgtggt gaagcaaggc tttgagcctc cctcctttgt gggctggttc     2280

cttggctggg atgatgatta ctggtctgtg gaccccttgg acagggccat ggctgagctg     2340

gctgcctga                                                             2349


<210>  710
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  711
<211>  951
<212>  DNA
<213>  Homo sapiens

<400>  711
atggcgtcta ccagccgttt ggatgctctt ccaagagtca catgtccaaa ccatccagat       60

gcgattttag tggaggacta cagagccggt gatatgatct gtcctgaatg tggcttggtt      120

gtaggtgacc gggttattga tgtgggatct gaatggcgaa ctttcagcaa tgacaaagca      180

acaaaagatc catctcgagt tggagattct cagaatcctc ttctgagtga tggagatttg      240

tctaccatga ttggcaaggg cacaggagct gcaagttttg acgaatttgg caattctaag      300

taccagaatc ggagaacaat gagcagttct gatcgggcaa tgatgaatgc attcaaagaa      360

atcactacca tggcagacag aatcaatcta cctcgaaata tagttgatcg aacaaataat      420

ttattcaagc aagtatatga acagaagagc ctgaagggaa gagctaatga tgctatagct      480

tctgcttgtc tctatattgc ctgtagacaa gaaggggttc ctaggacatt taaagaaata      540

tgtgccgtat cacgaatttc taagaaagaa attggtcggt gttttaaact tattttgaaa      600

gcgctagaaa ccagtgtgga tttgattaca actggggact tcatgtccag gttctgttcc      660

aacctttgtc ttcctaaaca agtacagatg gcagctacac atatagcccg taaagctgtg      720

gaactggact tggttcctgg gaggagcccc atctctgtgg cagcggcagc tatttacatg      780

gcctcacagg catcagctga aaagaggacc caaaaagaaa ttggagatat tgctggtgtt      840

gctgatgtta caatcagaca gtcctataga ctgatctatc ctcgagcccc agatctgttt      900

cctacagact tcaaatttga caccccagtg gacaaactac cacagctata a               951


<210>  712
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
1               5                   10                  15      


Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
            20                  25                  30          


Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
        35                  40                  45              


Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
    50                  55                  60                  


Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
65                  70                  75                  80  


Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                85                  90                  95      


Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
            100                 105                 110         


Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
        115                 120                 125             


Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
    130                 135                 140                 


Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
145                 150                 155                 160 


Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                165                 170                 175     


Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
            180                 185                 190         


Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
        195                 200                 205             


Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
    210                 215                 220                 


Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
225                 230                 235                 240 


Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                245                 250                 255     


Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
            260                 265                 270         


Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
        275                 280                 285             


Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Thr Asp Phe 
    290                 295                 300                 


Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
305                 310                 315     


<210>  713
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  713
atggcagcag cgtgtcggag cgtgaagggc ctggtggcgg taataaccgg aggagcctcg       60

ggcctgggcc tggccacggc ggagcgactt gtggggcagg gagcctctgc tgtgcttctg      120

gacctgccca actcgggtgg ggaggcccaa gccaagaagt taggaaacaa ctgcgttttc      180

gccccagccg acgtgacctc tgagaaggat gtgcaaacag ctctggctct agcaaaagga      240

aagtttggcc gtgtggatgt agctgtcaac tgtgcaggca tcgcggtggc tagcaagacg      300

tacaacttaa agaagggcca gacccatacc ttggaagact tccagcgagt tcttgatgtg      360

aatctcatgg gcaccttcaa tgtgatccgc ctggtggctg gtgagatggg ccagaatgaa      420

ccagaccagg gaggccaacg tggggtcatc atcaacactg ccagtgtggc tgccttcgag      480

ggtcaggttg gacaagctgc atactctgct tccaaggggg gaatagtggg catgacactg      540

cccattgctc gggatctggc tcccataggt atccgggtga tgaccattgc cccaggtctg      600

tttggcaccc cactgctgac cagcctccca gagaaagtgt gcaacttctt ggccagccaa      660

gtgcccttcc ctagccgact gggtgaccct gctgagtatg ctcacctcgt acaggccatc      720

atcgagaacc cattcctcaa tggagaggtc atccggctgg atggggccat tcgtatgcag      780

ccttga                                                                 786


<210>  714
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
            20                  25                  30          


Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
        35                  40                  45              


Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
    50                  55                  60                  


Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
65                  70                  75                  80  


Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                85                  90                  95      


Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
            100                 105                 110         


Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
        115                 120                 125             


Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
    130                 135                 140                 


Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
145                 150                 155                 160 


Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                165                 170                 175     


Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg 
            180                 185                 190         


Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser 
        195                 200                 205             


Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro 
    210                 215                 220                 


Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile 
225                 230                 235                 240 


Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala 
                245                 250                 255     


Ile Arg Met Gln Pro 
            260     


<210>  715
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  715
atgagcctct ttgatctctt ccggggcttt ttcggctttc ctggacctcg gagccacaga       60

gatccctttt ttggagggat gactcgagat gaagatgatg atgaggaaga agaagaagaa      120

gggggctcat ggggccgtgg gaacccaagg ttccatagtc ctcagcaccc ccctgaggaa      180

tttggcttcg gcttcagctt cagcccagga ggagggatac gtttccacga taacttcggc      240

tttgatgacc tagtacgaga tttcaatagc atcttcagcg atatgggggc ctggaccttg      300

ccttcccatc ctcctgaact tccaggtcct gagtcagaga cacctggtga gagactacgg      360

gagggacaga cacttcggga ctcaatgctt aagtatccag atagtcacca gcccaggatc      420

tttggggggg tcttggagag tgatgcaaga agtgaatccc cccaaccagc accagactgg      480

ggctcccaga ggccatttca taggtttgat gatgtatggc ctatggaccc ccatcctaga      540

accagagagg acaatgatct tgattcccag gtttcccagg agggtcttgg cccggttcta      600

cagccccagc ccaaatccta tttcaagagc atctctgtga ccaagatcac taaaccagat      660

gggatagtgg aggagcgccg gactgtggtg gacagtgagg gccggacaga gactacagta      720

acccgacacg aagcagatag cagtcctagg ggtgatccag aatcaccaag acctccagcc      780

ctggatgatg ccttttccat cctggactta ttcctgggac gttggttccg gtcccggtag      840


<210>  716
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
    130                 135                 140                 


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
145                 150                 155                 160 


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
                165                 170                 175     


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
            180                 185                 190         


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
        195                 200                 205             


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
    210                 215                 220                 


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
225                 230                 235                 240 


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
                245                 250                 255     


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
            260                 265                 270         


Gly Arg Trp Phe Arg Ser Arg 
        275                 


<210>  717
<211>  1722
<212>  DNA
<213>  Homo sapiens

<400>  717
atgcttcggt tacccacagt ctttcgccag atgagaccgg tgtccagggt actggctcct       60

catctcactc gggcttatgc caaagatgta aaatttggtg cagatgcccg agccttaatg      120

cttcaaggtg tagacctttt agccgatgct gtggccgtta caatggggcc aaagggaaga      180

acagtgatta ttgagcagag ttggggaagt cccaaagtaa caaaagatgg tgtgactgtt      240

gcaaagtcaa ttgacttaaa agataaatac aaaaacattg gagctaaact tgttcaagat      300

gttgccaata acacaaatga agaagctggg gatggcacta ccactgctac tgtactggca      360

cgctctatag ccaaggaagg cttcgagaag attagcaaag gtgctaatcc agtggaaatc      420

aggagaggtg tgatgttagc tgttgatgct gtaattgctg aacttaaaaa gcagtctaaa      480

cctgtgacca cccctgaaga aattgcacag gttgctacga tttctgcaaa cggagacaaa      540

gaaattggca atatcatctc tgatgcaatg aaaaaagttg gaagaaaggg tgtcatcaca      600

gtaaaggatg gaaaaacact gaatgatgaa ttagaaatta ttgaaggcat gaagtttgat      660

cgaggctata tttctccata ctttattaat acatcaaaag gtcagaaatg tgaattccag      720

gatgcctatg ttctgttgag tgaaaagaaa atttctagta tccagtccat tgtacctgct      780

cttgaaattg ccaatgctca ccgtaagcct ttggtcataa tcgctgaaga tgttgatgga      840

gaagctctaa gtacactcgt cttgaatagg ctaaaggttg gtcttcaggt tgtggcagtc      900

aaggctccag ggtttggtga caatagaaag aaccagctta aagatatggc tattgctact      960

ggtggtgcag tgtttggaga agagggattg accctgaatc ttgaagacgt tcagcctcat     1020

gacttaggaa aagttggaga ggtcattgtg accaaagacg atgccatgct cttaaaagga     1080

aaaggtgaca aggctcaaat tgaaaaacgt attcaagaaa tcattgagca gttagatgtc     1140

acaactagtg aatatgaaaa ggaaaaactg aatgaacggc ttgcaaaact ttcagatgga     1200

gtggctgtgc tgaaggttgg tgggacaagt gatgttgaag tgaatgaaaa gaaagacaga     1260

gttacagatg cccttaatgc tacaagagct gctgttgaag aaggcattgt tttgggaggg     1320

ggttgtgccc tccttcgatg cattccagcc ttggactcat tgactccagc taatgaagat     1380

caaaaaattg gtatagaaat tattaaaaga acactcaaaa ttccagcaat gaccattgct     1440

aagaatgcag gtgttgaagg atctttgata gttgagaaaa ttatgcaaag ttcctcagaa     1500

gttggttatg atgctatggc tggagatttt gtgaatatgg tggaaaaagg aatcattgac     1560

ccaacaaagg ttgtgagaac tgctttattg gatgctgctg gtgtggcctc tctgttaact     1620

acagcagaag ttgtagtcac agaaattcct aaagaagaga aggaccctgg aatgggtgca     1680

atgggtggaa tgggaggtgg tatgggaggt ggcatgttct aa                        1722


<210>  718
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  718

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  719
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  719
atggccgggg ggccgggccc gggggagccc gcagcccccg gcgcccagca cttcttgtac       60

gaggtgccgc cctgggtcat gtgccgcttc tacaaagtga tggacgccct ggagcccgcc      120

gactggtgcc agttcgccgc cctgatcgtg cgcgaccaga ccgagctgcg gctgtgcgag      180

cgctccgggc agcgcacggc cagcgtcctg tggccctgga tcaaccgcaa cgcccgtgtg      240

gccgacctcg tgcacatcct cacgcacctg cagctgctcc gtgcgcggga catcatcaca      300

gcctggcacc ctcccgcccc gcttccgtcc ccaggcacca ctgccccgag gcccagcagc      360

atccctgcac ccgccgaggc cgaggcctgg agcccccgga agttgccatc ctcagcctcc      420

accttcctct ccccagcttt tccaggctcc cagacccatt cagggcctga gctcggcctg      480

gtcccaagcc ctgcttccct gtggcctcca ccgccatctc cagccccttc ttctaccaag      540

ccaggcccag agagctcagt gtccctcctg cagggagccc gcccctttcc gttttgctgg      600

cccctctgtg agatttcccg gggcacccac aacttctcgg aggagctcaa gatcggggag      660

ggtggctttg ggtgcgtgta ccgggcggtg atgaggaaca cggtgtatgc tgtgaagagg      720

ctgaaggaga acgctgacct ggagtggact gcagtgaagc agagcttcct gaccgaggtg      780

gagcagctgt ccaggtttcg tcacccaaac attgtggact ttgctggcta ctgtgctcag      840

aacggcttct actgcctggt gtacggcttc ctgcccaacg gctccctgga ggaccgtctc      900

cactgccaga cccaggcctg cccacctctc tcctggcctc agcgactgga catccttctg      960

ggtacagccc gggcaattca gtttctacat caggacagcc ccagcctcat ccatggagac     1020

atcaagagtt ccaacgtcct tctggatgag aggctgacac ccaagctggg agactttggc     1080

ctggcccggt tcagccgctt tgccgggtcc agccccagcc agagcagcat ggtggcccgg     1140

acacagacag tgcggggcac cctggcctac ctgcccgagg agtacatcaa gacgggaagg     1200

ctggctgtgg acacggacac cttcagcttt ggggtggtag tgctagagac cttggctggt     1260

cagagggctg tgaagacgca cggtgccagg accaagtatc tgaaagacct ggtggaagag     1320

gaggctgagg aggctggagt ggctttgaga agcacccaga gcacactgca agcaggtctg     1380

gctgcagatg cctgggctgc tcccatcgcc atgcagatct acaagaagca cctggacccc     1440

aggcccgggc cctgcccacc tgagctgggc ctgggcctgg gccagctggc ctgctgctgc     1500

ctgcaccgcc gggccaaaag gaggcctcct atgacccagg tgtacgagag gctagagaag     1560

ctgcaggcag tggtggcggg ggtgcccggg cattcggagg ccgccagctg catcccccct     1620

tccccgcagg agaactccta cgtgtccagc actggcagag cccacagtgg ggctgctcca     1680

tggcagcccc tggcagcgcc atcaggagcc agtgcccagg cagcagagca gctgcagaga     1740

ggccccaacc agcccgtgga gagtgacgag agcctaggcg gcctctctgc tgccctgcgc     1800

tcctggcact tgactccaag ctgccctctg gacccagcac ccctcaggga ggccggctgt     1860

cctcaggggg acacggcagg agaatcgagc tgggggagtg gcccaggatc ccggcccaca     1920

gccgtggaag gactggccct tggcagctct gcatcatcgt cgtcagagcc accgcagatt     1980

atcatcaacc ctgcccgaca gaagatggtc cagaagctgg ccctgtacga ggatggggcc     2040

ctggacagcc tgcagctgct gtcgtccagc tccctcccag gcttgggcct ggaacaggac     2100

aggcaggggc ccgaagaaag tgatgaattt cagagctga                            2139


<210>  720
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


<210>  721
<211>  3150
<212>  DNA
<213>  Homo sapiens

<400>  721
atggggagcc ggacgccaga gtcccctctc cacgccgtgc agctgcgctg gggcccccgg       60

cgccgacccc cgctgctgcc gctgctgttg ctgctgctgc cgccgccacc cagggtcggg      120

ggcttcaact tagacgcgga ggccccagca gtactctcgg ggcccccggg ctccttcttc      180

ggattctcag tggagtttta ccggccggga acagacgggg tcagtgtgct ggtgggagca      240

cccaaggcta ataccagcca gccaggagtg ctgcagggtg gtgctgtcta cctctgtcct      300

tggggtgcca gccccacaca gtgcaccccc attgaatttg acagcaaagg ctctcggctc      360

ctggagtcct cactgtccag ctcagaggga gaggagcctg tggagtacaa gtccttgcag      420

tggttcgggg caacagttcg agcccatggc tcctccatct tggcatgcgc tccactgtac      480

agctggcgca cagagaagga gccactgagc gaccccgtgg gcacctgcta cctctccaca      540

gataacttca cccgaattct ggagtatgca ccctgccgct cagatttcag ctgggcagca      600

ggacagggtt actgccaagg aggcttcagt gccgagttca ccaagactgg ccgtgtggtt      660

ttaggtggac caggaagcta tttctggcaa ggccagatcc tgtctgccac tcaggagcag      720

attgcagaat cttattaccc cgagtacctg atcaacctgg ttcaggggca gctgcagact      780

cgccaggcca gttccatcta tgatgacagc tacctaggat actctgtggc tgttggtgaa      840

ttcagtggtg atgacacaga agactttgtt gctggtgtgc ccaaagggaa cctcacttac      900

ggctatgtca ccatccttaa tggctcagac attcgatccc tctacaactt ctcaggggaa      960

cagatggcct cctactttgg ctatgcagtg gccgccacag acgtcaatgg ggatgggctg     1020

gatgacttgc tggtgggggc acccctgctc atggatcgga cccctgacgg gcggcctcag     1080

gaggtgggca gggtctacgt ctacctgcag cacccagccg gcatagagcc cacgcccacc     1140

cttaccctca ctggccatga tgagtttggc cgatttggca gctccttgac ccccctgggg     1200

gacctggacc aggatggcta caatgatgtg gccatcgggg ctccctttgg tggggagacc     1260

cagcagggag tagtgtttgt atttcctggg ggcccaggag ggctgggctc taagccttcc     1320

caggttctgc agcccctgtg ggcagccagc cacaccccag acttctttgg ctctgccctt     1380

cgaggaggcc gagacctgga tggcaatgga tatcctgatc tgattgtggg gtcctttggt     1440

gtggacaagg ctgtggtata caggggccgc cccatcgtgt ccgctagtgc ctccctcacc     1500

atcttccccg ccatgttcaa cccagaggag cggagctgca gcttagaggg gaaccctgtg     1560

gcctgcatca accttagctt ctgcctcaat gcttctggaa aacacgttgc tgactccatt     1620

ggtttcacag tggaacttca gctggactgg cagaagcaga agggaggggt acggcgggca     1680

ctgttcctgg cctccaggca ggcaaccctg acccagaccc tgctcatcca gaatggggct     1740

cgagaggatt gcagagagat gaagatctac ctcaggaacg agtcagaatt tcgagacaaa     1800

ctctcgccga ttcacatcgc tctcaacttc tccttggacc cccaagcccc agtggacagc     1860

cacggcctca ggccagccct acattatcag agcaagagcc ggatagagga caaggctcag     1920

atcttgctgg actgtggaga agacaacatc tgtgtgcctg acctgcagct ggaagtgttt     1980

ggggagcaga accatgtgta cctgggtgac aagaatgccc tgaacctcac tttccatgcc     2040

cagaatgtgg gtgagggtgg cgcctatgag gctgagcttc gggtcaccgc ccctccagag     2100

gctgagtact caggactcgt cagacaccca gggaacttct ccagcctgag ctgtgactac     2160

tttgccgtga accagagccg cctgctggtg tgtgacctgg gcaaccccat gaaggcagga     2220

gccagtctgt ggggtggcct tcggtttaca gtccctcatc tccgggacac taagaaaacc     2280

atccagtttg acttccagat cctcagcaag aatctcaaca actcgcaaag cgacgtggtt     2340

tcctttcggc tctccgtgga ggctcaggcc caggtcaccc tgaacggtgt ctccaagcct     2400

gaggcagtgc tattcccagt aagcgactgg catccccgag accagcctca gaaggaggag     2460

gacctgggac ctgctgtcca ccatgtctat gagctcatca accaaggccc cagctccatt     2520

agccagggtg tgctggaact cagctgtccc caggctctgg aaggtcagca gctcctatat     2580

gtgaccagag ttacgggact caactgcacc accaatcacc ccattaaccc aaagggcctg     2640

gagttggatc ccgagggttc cctgcaccac cagcaaaaac gggaagctcc aagccgcagc     2700

tctgcttcct cgggacctca gatcctgaaa tgcccggagg ctgagtgttt caggctgcgc     2760

tgtgagctcg ggcccctgca ccaacaagag agccaaagtc tgcagttgca tttccgagtc     2820

tgggccaaga ctttcttgca gcgggagcac cagccattta gcctgcagtg tgaggctgtg     2880

tacaaagccc tgaagatgcc ctaccgaatc ctgcctcggc agctgcccca aaaagagcgt     2940

caggtggcca cagctgtgca atggaccaag gcagaaggca gctatggcgt cccactgtgg     3000

atcatcatcc tagccatcct gtttggcctc ctgctcctag gtctactcat ctacatcctc     3060

tacaagcttg gattcttcaa acgctccctc ccatatggca ccgccatgga aaaagctcag     3120

ctcaagcctc cagccacctc tgatgcctga                                      3150


<210>  722
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  723
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  723
atgtgggtcc cggttgtctt cctcaccctg tccgtgacgt ggattggtgc tgcacccctc       60

atcctgtctc ggattgtggg aggctgggag tgcgagaagc attcccaacc ctggcaggtg      120

cttgtggcct ctcgtggcag ggcagtctgc ggcggtgttc tggtgcaccc ccagtgggtc      180

ctcacagctg cccactgcat caggaacaaa agcgtgatct tgctgggtcg gcacagcctg      240

tttcatcctg aagacacagg ccaggtattt caggtcagcc acagcttccc acacccgctc      300

tacgatatga gcctcctgaa gaatcgattc ctcaggccag gtgatgactc cagccacgac      360

ctcatgctgc tccgcctgtc agagcctgcc gagctcacgg atgctgtgaa ggtcatggac      420

ctgcccaccc aggagccagc actggggacc acctgctacg cctcaggctg gggcagcatt      480

gaaccagagg agttcttgac cccaaagaaa cttcagtgtg tggacctcca tgttatttcc      540

aatgacgtgt gtgcgcaagt tcaccctcag aaggtgacca agttcatgct gtgtgctgga      600

cgctggacag ggggcaaaag cacctgctcg ggtgattctg ggggcccact tgtctgtaat      660

ggtgtgcttc aaggtatcac gtcatggggc agtgaaccat gtgccctgcc cgaaaggcct      720

tccctgtaca ccaaggtggt gcattaccgg aagtggatca aggacaccat cgtggccaac      780

ccctga                                                                 786


<210>  724
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  724

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  725
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  725
atgtccacca acgagaatgc taatacacca gctgcccgtc ttcacagatt caagaacaag       60

ggaaaagaca gtacagaaat gaggcgtcgc agaatagagg tcaatgtgga gctgaggaaa      120

gctaagaagg atgaccagat gctgaagagg agaaatgtaa gctcatttcc tgatgatgct      180

acttctccgc tgcaggaaaa ccgcaacaac cagggcactg taaattggtc tgttgatgac      240

attgtcaaag gcataaatag cagcaatgtg gaaaatcagc tccaagctac tcaagctgcc      300

aggaaactac tttccagaga aaaacagccc cccatagaca acataatccg ggctggtttg      360

attccgaaat ttgtgtcctt cttgggcaga actgattgta gtcccattca gtttgaatct      420

gcttgggcac tcactaacat tgcttctggg acatcagaac aaaccaaggc tgtggtagat      480

ggaggtgcca tcccagcatt catttctctg ttggcatctc cccatgctca catcagtgaa      540

caagctgtct gggctctagg aaacattgca ggtgatggct cagtgttccg agacttggtt      600

attaagtacg gtgcagttga cccactgttg gctctccttg cagttcctga tatgtcatct      660

ttagcatgtg gctacttacg taatcttacc tggacacttt ctaatctttg ccgcaacaag      720

aatcctgcac ccccgataga tgctgttgag cagattcttc ctaccttagt tcggctcctg      780

catcatgatg atccagaagt attagcagat acctgctggg ctatttccta ccttactgat      840

ggtccaaatg aacgaattgg catggtggtg aaaacaggag ttgtgcccca acttgtgaag      900

cttctaggag cttctgaatt gccaattgtg actcctgccc taagagccat agggaatatt      960

gtcactggta cagatgaaca gactcaggtt gtgattgatg caggagcact cgccgtcttt     1020

cccagcctgc tcaccaaccc caaaactaac attcagaagg aagctacgtg gacaatgtca     1080

aacatcacag ccggccgcca ggaccagata cagcaagttg tgaatcatgg attagtccca     1140

ttccttgtca gtgttctctc taaggcagat tttaagacac aaaaggaagc tgtgtgggcc     1200

gtgaccaact ataccagtgg tggaacagtt gaacagattg tgtaccttgt tcactgtggc     1260

ataatagaac cgttgatgaa cctcttaact gcaaaagata ccaagattat tctggttatc     1320

ctggatgcca tttcaaatat ctttcaggct gctgagaaac taggtgaaac tgagaaactt     1380

agtataatga ttgaagaatg tggaggctta gacaaaattg aagctctaca aaaccatgaa     1440

aatgagtctg tgtataaggc ttcgttaagc ttaattgaga agtatttctc tgtagaggaa     1500

gaggaagatc aaaacgttgt accagaaact acctctgaag gctacacttt ccaagttcag     1560

gatggggctc ctgggacctt taacttttag                                      1590


<210>  726
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Ser Thr Asn Glu Asn Ala Asn Thr Pro Ala Ala Arg Leu His Arg 
1               5                   10                  15      


Phe Lys Asn Lys Gly Lys Asp Ser Thr Glu Met Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Val Asn Val Glu Leu Arg Lys Ala Lys Lys Asp Asp Gln Met Leu 
        35                  40                  45              


Lys Arg Arg Asn Val Ser Ser Phe Pro Asp Asp Ala Thr Ser Pro Leu 
    50                  55                  60                  


Gln Glu Asn Arg Asn Asn Gln Gly Thr Val Asn Trp Ser Val Asp Asp 
65                  70                  75                  80  


Ile Val Lys Gly Ile Asn Ser Ser Asn Val Glu Asn Gln Leu Gln Ala 
                85                  90                  95      


Thr Gln Ala Ala Arg Lys Leu Leu Ser Arg Glu Lys Gln Pro Pro Ile 
            100                 105                 110         


Asp Asn Ile Ile Arg Ala Gly Leu Ile Pro Lys Phe Val Ser Phe Leu 
        115                 120                 125             


Gly Arg Thr Asp Cys Ser Pro Ile Gln Phe Glu Ser Ala Trp Ala Leu 
    130                 135                 140                 


Thr Asn Ile Ala Ser Gly Thr Ser Glu Gln Thr Lys Ala Val Val Asp 
145                 150                 155                 160 


Gly Gly Ala Ile Pro Ala Phe Ile Ser Leu Leu Ala Ser Pro His Ala 
                165                 170                 175     


His Ile Ser Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp 
            180                 185                 190         


Gly Ser Val Phe Arg Asp Leu Val Ile Lys Tyr Gly Ala Val Asp Pro 
        195                 200                 205             


Leu Leu Ala Leu Leu Ala Val Pro Asp Met Ser Ser Leu Ala Cys Gly 
    210                 215                 220                 


Tyr Leu Arg Asn Leu Thr Trp Thr Leu Ser Asn Leu Cys Arg Asn Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Pro Ile Asp Ala Val Glu Gln Ile Leu Pro Thr Leu 
                245                 250                 255     


Val Arg Leu Leu His His Asp Asp Pro Glu Val Leu Ala Asp Thr Cys 
            260                 265                 270         


Trp Ala Ile Ser Tyr Leu Thr Asp Gly Pro Asn Glu Arg Ile Gly Met 
        275                 280                 285             


Val Val Lys Thr Gly Val Val Pro Gln Leu Val Lys Leu Leu Gly Ala 
    290                 295                 300                 


Ser Glu Leu Pro Ile Val Thr Pro Ala Leu Arg Ala Ile Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Thr Asp Glu Gln Thr Gln Val Val Ile Asp Ala Gly Ala 
                325                 330                 335     


Leu Ala Val Phe Pro Ser Leu Leu Thr Asn Pro Lys Thr Asn Ile Gln 
            340                 345                 350         


Lys Glu Ala Thr Trp Thr Met Ser Asn Ile Thr Ala Gly Arg Gln Asp 
        355                 360                 365             


Gln Ile Gln Gln Val Val Asn His Gly Leu Val Pro Phe Leu Val Ser 
    370                 375                 380                 


Val Leu Ser Lys Ala Asp Phe Lys Thr Gln Lys Glu Ala Val Trp Ala 
385                 390                 395                 400 


Val Thr Asn Tyr Thr Ser Gly Gly Thr Val Glu Gln Ile Val Tyr Leu 
                405                 410                 415     


Val His Cys Gly Ile Ile Glu Pro Leu Met Asn Leu Leu Thr Ala Lys 
            420                 425                 430         


Asp Thr Lys Ile Ile Leu Val Ile Leu Asp Ala Ile Ser Asn Ile Phe 
        435                 440                 445             


Gln Ala Ala Glu Lys Leu Gly Glu Thr Glu Lys Leu Ser Ile Met Ile 
    450                 455                 460                 


Glu Glu Cys Gly Gly Leu Asp Lys Ile Glu Ala Leu Gln Asn His Glu 
465                 470                 475                 480 


Asn Glu Ser Val Tyr Lys Ala Ser Leu Ser Leu Ile Glu Lys Tyr Phe 
                485                 490                 495     


Ser Val Glu Glu Glu Glu Asp Gln Asn Val Val Pro Glu Thr Thr Ser 
            500                 505                 510         


Glu Gly Tyr Thr Phe Gln Val Gln Asp Gly Ala Pro Gly Thr Phe Asn 
        515                 520                 525             


Phe 
    


<210>  727
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  727
atggttcact gtgccggctg caaaaggccc atcctggacc gctttctctt gaacgtgctg       60

gacagggcct ggcacgtcaa gtgcgtccag tgctgtgaat gtaaatgcaa cctgaccgag      120

aagtgcttct ccagggaagg caaactctac tgcaagaacg acttcttccg gtgtttcggt      180

accaaatgcg caggctgcgc tcagggcatc tcccctagcg acctggtgcg gagagcgcgg      240

agcaaagtgt ttcacctgaa ctgcttcacc tgcatgatgt gtaacaagca gctctccact      300

ggcgaggaac tctacatcat cgacgagaat aagttcgtct gcaaagagga ttacctaagt      360

aacagcagtg ttgccaaaga gaacagcctt cactcggcca ccacgggcag tgaccccagt      420

ttgtctccgg attcccaaga cccgtcgcag gacgacgcca aggactcgga gagcgccaac      480

gtgtcggaca aggaagcggg tagcaacgag aatgacgacc agaacctggg cgccaagcgg      540

cggggaccgc gcaccaccat caaagccaag cagctggaga cgctgaaggc cgccttcgct      600

gctacaccca agcccacccg ccacatccgc gagcagctgg cgcaggagac cggcctcaac      660

atgcgcgtca ttcaggtctg gttccagaac cggcgctcca aggagcggag gatgaagcag      720

ctgagcgccc tgggcgcccg gcgccacgcc ttcttccgca gtccgcgccg gatgcggccg      780

ctggtggacc gcctggagcc gggcgagctc atccccaatg gtcccttctc cttctacgga      840

gattaccaga gcgagtacta cgggcccggg ggcaactacg acttcttccc gcaaggcccc      900

ccgtcctcgc aggcccagac accagtggac ctacccttcg tgccgtcatc tgggccgtcc      960

gggacgcccc tgggtggcct ggagcacccg ctgccgggcc accacccgtc gagcgaggcg     1020

cagcggttta ccgacatcct ggcgcaccca cccggggact cgcccagccc cgagcccagc     1080

ctgcccgggc ctctgcactc catgtcggcc gaggtcttcg gacccagccc gcccttctcg     1140

tcgctgtcgg tcaacggtgg ggcgagctac ggaaaccacc tgtcccaccc ccccgaaatg     1200

aacgaggcgg ccgtgtggta g                                               1221


<210>  728
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Val His Cys Ala Gly Cys Lys Arg Pro Ile Leu Asp Arg Phe Leu 
1               5                   10                  15      


Leu Asn Val Leu Asp Arg Ala Trp His Val Lys Cys Val Gln Cys Cys 
            20                  25                  30          


Glu Cys Lys Cys Asn Leu Thr Glu Lys Cys Phe Ser Arg Glu Gly Lys 
        35                  40                  45              


Leu Tyr Cys Lys Asn Asp Phe Phe Arg Cys Phe Gly Thr Lys Cys Ala 
    50                  55                  60                  


Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Arg Ala Arg 
65                  70                  75                  80  


Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Met Cys Asn Lys 
                85                  90                  95      


Gln Leu Ser Thr Gly Glu Glu Leu Tyr Ile Ile Asp Glu Asn Lys Phe 
            100                 105                 110         


Val Cys Lys Glu Asp Tyr Leu Ser Asn Ser Ser Val Ala Lys Glu Asn 
        115                 120                 125             


Ser Leu His Ser Ala Thr Thr Gly Ser Asp Pro Ser Leu Ser Pro Asp 
    130                 135                 140                 


Ser Gln Asp Pro Ser Gln Asp Asp Ala Lys Asp Ser Glu Ser Ala Asn 
145                 150                 155                 160 


Val Ser Asp Lys Glu Ala Gly Ser Asn Glu Asn Asp Asp Gln Asn Leu 
                165                 170                 175     


Gly Ala Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His 
        195                 200                 205             


Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile 
    210                 215                 220                 


Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln 
225                 230                 235                 240 


Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg 
                245                 250                 255     


Arg Met Arg Pro Leu Val Asp Arg Leu Glu Pro Gly Glu Leu Ile Pro 
            260                 265                 270         


Asn Gly Pro Phe Ser Phe Tyr Gly Asp Tyr Gln Ser Glu Tyr Tyr Gly 
        275                 280                 285             


Pro Gly Gly Asn Tyr Asp Phe Phe Pro Gln Gly Pro Pro Ser Ser Gln 
    290                 295                 300                 


Ala Gln Thr Pro Val Asp Leu Pro Phe Val Pro Ser Ser Gly Pro Ser 
305                 310                 315                 320 


Gly Thr Pro Leu Gly Gly Leu Glu His Pro Leu Pro Gly His His Pro 
                325                 330                 335     


Ser Ser Glu Ala Gln Arg Phe Thr Asp Ile Leu Ala His Pro Pro Gly 
            340                 345                 350         


Asp Ser Pro Ser Pro Glu Pro Ser Leu Pro Gly Pro Leu His Ser Met 
        355                 360                 365             


Ser Ala Glu Val Phe Gly Pro Ser Pro Pro Phe Ser Ser Leu Ser Val 
    370                 375                 380                 


Asn Gly Gly Ala Ser Tyr Gly Asn His Leu Ser His Pro Pro Glu Met 
385                 390                 395                 400 


Asn Glu Ala Ala Val Trp 
                405     


<210>  729
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  729
atggcggcgc cggaggcgga ggttctgtcc tcagccgcag tccctgattt ggagtggtat       60

gagaagtccg aagaaactca cgcctcccag atagaactac ttgagacaag ctctacgcag      120

gaacctctca acgcttcgga ggccttttgc ccaagagact gcatggtacc agtggtgttt      180

cctgggcctg tgagccagga aggctgctgt cagtttactt gtgaacttct aaagcatatc      240

atgtatcaac gccagcagct ccctctgccc tatgaacagc ttaagcactt ttaccgaaaa      300

ccttctcccc aggcagagga gatgctgaag aagaaacctc gggccaccac tgaggtgagc      360

agcaggaaat gccaacaagc cctggcagaa ctggagagtg tcctcagcca cctggaggac      420

ttctttgcac ggacactagt accgcgagtg ctgattctcc ttgggggcaa tgccctaagc      480

cccaaggagt tctatgaact cgacttgtct ctgctggccc cctacagcgt ggaccagagc      540

ctgagcacag cagcttgttt gcgccgtctc ttccgagcca tattcatggc tgatgccttt      600

agcgagcttc aggctcctcc actcatgggc accgtcgtca tggcacaggg acaccgcaac      660

tgtggagaag attggtttcg acccaagctc aactatcgag tgcccagccg gggccataaa      720

ctgactgtga ccctgtcatg tggcagacct tccatccgaa ccacggcttg ggaagactac      780

atttggttcc aggcaccagt gacatttaaa ggcttccgcg agtga                      825


<210>  730
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  730

Met Ala Ala Pro Glu Ala Glu Val Leu Ser Ser Ala Ala Val Pro Asp 
1               5                   10                  15      


Leu Glu Trp Tyr Glu Lys Ser Glu Glu Thr His Ala Ser Gln Ile Glu 
            20                  25                  30          


Leu Leu Glu Thr Ser Ser Thr Gln Glu Pro Leu Asn Ala Ser Glu Ala 
        35                  40                  45              


Phe Cys Pro Arg Asp Cys Met Val Pro Val Val Phe Pro Gly Pro Val 
    50                  55                  60                  


Ser Gln Glu Gly Cys Cys Gln Phe Thr Cys Glu Leu Leu Lys His Ile 
65                  70                  75                  80  


Met Tyr Gln Arg Gln Gln Leu Pro Leu Pro Tyr Glu Gln Leu Lys His 
                85                  90                  95      


Phe Tyr Arg Lys Pro Ser Pro Gln Ala Glu Glu Met Leu Lys Lys Lys 
            100                 105                 110         


Pro Arg Ala Thr Thr Glu Val Ser Ser Arg Lys Cys Gln Gln Ala Leu 
        115                 120                 125             


Ala Glu Leu Glu Ser Val Leu Ser His Leu Glu Asp Phe Phe Ala Arg 
    130                 135                 140                 


Thr Leu Val Pro Arg Val Leu Ile Leu Leu Gly Gly Asn Ala Leu Ser 
145                 150                 155                 160 


Pro Lys Glu Phe Tyr Glu Leu Asp Leu Ser Leu Leu Ala Pro Tyr Ser 
                165                 170                 175     


Val Asp Gln Ser Leu Ser Thr Ala Ala Cys Leu Arg Arg Leu Phe Arg 
            180                 185                 190         


Ala Ile Phe Met Ala Asp Ala Phe Ser Glu Leu Gln Ala Pro Pro Leu 
        195                 200                 205             


Met Gly Thr Val Val Met Ala Gln Gly His Arg Asn Cys Gly Glu Asp 
    210                 215                 220                 


Trp Phe Arg Pro Lys Leu Asn Tyr Arg Val Pro Ser Arg Gly His Lys 
225                 230                 235                 240 


Leu Thr Val Thr Leu Ser Cys Gly Arg Pro Ser Ile Arg Thr Thr Ala 
                245                 250                 255     


Trp Glu Asp Tyr Ile Trp Phe Gln Ala Pro Val Thr Phe Lys Gly Phe 
            260                 265                 270         


Arg Glu 
        


<210>  731
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  731
atggcggctc cgagcccgag cggcggcggc ggctccgggg gcggcagcgg cagcggcacc       60

cccggccccg tagggtcccc ggcgccaggc cacccggccg tcagcagcat gcagggtaaa      120

cgcaaagcac tgaagttgaa ttttgcaaat ccacctttca aatctacagc aaggtttact      180

ctgaatccca atcctacagg agttcaaaac ccacacatag agagactgag aacacacagc      240

attgagtcat caggaaaact gaagatctcc cctgaacaac actgggattt cactgcagag      300

gacttgaaag accttggaga aattggacga ggagcttatg gttctgtcaa cagaatggtc      360

cacaaaccaa gtgggcaaat aatggcagtt aaaagaattc ggtcaacagt ggatgaaaaa      420

gaacaaaaac aacttcttat ggatttggat gtagtaatgc ggagtagtga ttgcccatac      480

attgttcagt tttatggtgc actcttcaga gagggtgact gttggatctg tatggaactc      540

atgtctacct cgtttgataa gttttacaaa tatgtatata gtgtattaga tgatgttatt      600

ccagaagaaa ttttaggcaa aatcacttta gcaactgtga aagcactaaa ccacttaaaa      660

gaaaacttga aaattattca cagagatatc aaaccttcca atattcttct ggacagaagt      720

ggaaatatta agctctgtga cttcggcatc agtggacagc ttgtggactc tattgccaag      780

acaagagatg ctggctgtag gccatacatg gcacctgaaa gaatagaccc aagcgcatca      840

cgacaaggat atgatgtccg ctctgatgtc tggagtttgg ggatcacatt gtatgagttg      900

gccacaggcc gatttcctta tccaaagtgg aatagtgtat ttgatcaact aacacaagtc      960

gtgaaaggag atcctccgca gctgagtaat tctgaggaaa gggaattctc cccgagtttc     1020

atcaactttg tcaacttgtg ccttacgaag gatgaatcca aaaggccaaa gtataaagag     1080

cttctgaaac atccctttat tttgatgtat gaagaacgtg ccgttgaggt cgcatgctat     1140

gtttgtaaaa tcctggatca aatgccagct actcccagct ctcccatgta tgtcgattga     1200


<210>  732
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Arg Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210>  733
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  733
atggaactga tggatgccaa cttatgtcaa gtgattcaga tggaattaga ccatgagcga       60

atgtcttacc tgctgtacca aatgttgtgt ggcattaagc acctccattc tgctggaatt      120

attcacaggg atttaaaacc aagtaacatt gtagtcaagt ctgattgcac attgaaaatc      180

ctggactttg gactggccag gacagcaggc acaagcttca tgatgactcc atatgtggtg      240

acacgttatt acagagcccc tgaggtcatc ctggggatgg gctacaagga gaacgttgac      300

atgtggtcag tagggtgcat catgggagaa atgataaaag gtgcagtgct gtttcctggc      360

actgatcata ttgaccagtg gaataaggta attgaacaac taggaacacc atgtccagaa      420

ttcatgaaga aattgcaacc cacagtaaga aactatgtgg agaatcggcc caagtatgcg      480

ggactcacct tccccaaact cttcccagat tccctcttcc cagcggactc cgagcacaat      540

aaactcaaag ccagccaagc cagggacttg ttgtcaaaga tgctagtgat tgacccagca      600

aaaagaatat cagtggacga cgccttacag catccctaca tcaacgtctg gtatgaccca      660

gccgaagtgg aggcgcctcc acctcagata tatgacaagc agttggatga aagagaacac      720

acaattgaag aatggaaaga acttatctac aaggaagtaa tgaattcaga agaaaagact      780

aaaaatggtg tagtaaaagg acagccttct ccttcaggtg cagcagtgaa cagcagtgag      840

agtctccctc catcctcgtc tgtcaatgac atctcctcca tgtccaccga ccagaccctg      900

gcatctgaca ctgacagcag cctggaagcc tcggcaggac ccctgggttg ttgcaggtga      960


<210>  734
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Glu Leu Met Asp Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu 
1               5                   10                  15      


Asp His Glu Arg Met Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile 
            20                  25                  30          


Lys His Leu His Ser Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser 
        35                  40                  45              


Asn Ile Val Val Lys Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly 
    50                  55                  60                  


Leu Ala Arg Thr Ala Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val 
65                  70                  75                  80  


Thr Arg Tyr Tyr Arg Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys 
                85                  90                  95      


Glu Asn Val Asp Met Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile 
            100                 105                 110         


Lys Gly Ala Val Leu Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn 
        115                 120                 125             


Lys Val Ile Glu Gln Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys 
    130                 135                 140                 


Leu Gln Pro Thr Val Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Ala 
145                 150                 155                 160 


Gly Leu Thr Phe Pro Lys Leu Phe Pro Asp Ser Leu Phe Pro Ala Asp 
                165                 170                 175     


Ser Glu His Asn Lys Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser 
            180                 185                 190         


Lys Met Leu Val Ile Asp Pro Ala Lys Arg Ile Ser Val Asp Asp Ala 
        195                 200                 205             


Leu Gln His Pro Tyr Ile Asn Val Trp Tyr Asp Pro Ala Glu Val Glu 
    210                 215                 220                 


Ala Pro Pro Pro Gln Ile Tyr Asp Lys Gln Leu Asp Glu Arg Glu His 
225                 230                 235                 240 


Thr Ile Glu Glu Trp Lys Glu Leu Ile Tyr Lys Glu Val Met Asn Ser 
                245                 250                 255     


Glu Glu Lys Thr Lys Asn Gly Val Val Lys Gly Gln Pro Ser Pro Ser 
            260                 265                 270         


Gly Ala Ala Val Asn Ser Ser Glu Ser Leu Pro Pro Ser Ser Ser Val 
        275                 280                 285             


Asn Asp Ile Ser Ser Met Ser Thr Asp Gln Thr Leu Ala Ser Asp Thr 
    290                 295                 300                 


Asp Ser Ser Leu Glu Ala Ser Ala Gly Pro Leu Gly Cys Cys Arg 
305                 310                 315                 


<210>  735
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  735
atgtctcagg agaggcccac gttctaccgg caggagctga acaagacaat ctgggaggtg       60

cccgagcgtt accagaacct gtctccagtg ggctctggcg cctatggctc tgtgtgtgct      120

gcttttgaca caaaaacggg gttacgtgtg gcagtgaaga agctctccag accatttcag      180

tccatcattc atgcgaaaag aacctacaga gaactgcggt tacttaaaca tatgaaacat      240

gaaaatgtga ttggtctgtt ggacgttttt acacctgcaa ggtctctgga ggaattcaat      300

gatgtgtatc tggtgaccca tctcatgggg gcagatctga acaacattgt gaaatgtcag      360

aagcttacag atgaccatgt tcagttcctt atctaccaaa ttctccgagg tctaaagtat      420

atacattcag ctgacataat tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa      480

gactgtgagc tgaagattct ggattttgga ctggctcggc acacagatga tgaaatgaca      540

ggctacgtgg ccactaggtg gtacagggct cctgagatca tgctgaactg gatgcattac      600

aaccagacag ttgatatttg gtcagtggga tgcataatgg ccgagctgtt gactggaaga      660

acattgtttc ctggtacaga ccatattgat cagttgaagc tcattttaag actcgttgga      720

accccagggg ctgagctttt gaagaaaatc tcctcagagt ctgcaagaaa ctatattcag      780

tctttgactc agatgccgaa gatgaacttt gcgaatgtat ttattggtgc caatcccctg      840

gctgtcgact tgctggagaa gatgcttgta ttggactcag ataagagaat tacagcggcc      900

caagcccttg cacatgccta ctttgctcag taccacgatc ctgatgatga accagtggcc      960

gatccttatg atcagtcctt tgaaagcagg gacctcctta tagatgagtg gaaaagcctg     1020

acctatgatg aagtcatcag ctttgtgcca ccaccccttg accaagaaga gatggagtcc     1080

tga                                                                   1083


<210>  736
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  736

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  737
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  737
atggatggtg aaacagcaga ggagcagggg ggccctgtgc ccccgccagt tgcacccggc       60

ggacccggct tgggcggtgc tccggggggg cggcgggagc ccaagaagta cgcagtgacc      120

gacgactacc agttgtccaa gcaggtgctg ggcctgggtg tgaacggcaa agtgctggag      180

tgcttccatc ggcgcactgg acagaagtgt gccctgaagc tcctgtatga cagccccaag      240

gcccggcagg aggtagacca tcactggcag gcttctggcg gcccccatat tgtctgcatc      300

ctggatgtgt atgagaacat gcaccatggc aagcgctgtc tcctcatcat catggaatgc      360

atggaaggtg gtgagttgtt cagcaggatt caggagcgtg gcgaccaggc tttcactgag      420

agagaagctg cagagataat gcgggatatt ggcactgcca tccagtttct gcacagccat      480

aacattgccc accgagatgt caagcctgaa aacctactct acacatctaa ggagaaagac      540

gcagtgctta agctcaccga ttttggcttt gctaaggaga ccacccaaaa tgccctgcag      600

acaccctgct atactcccta ttatgtggcc cctgaggtcc tgggtccaga gaagtatgac      660

aagtcatgtg acatgtggtc cctgggtgtc atcatgtaca tcctcctttg tggcttccca      720

cccttctact ccaacacggg ccaggccatc tccccgggga tgaagaggag gattcgcctg      780

ggccagtacg gcttccccaa tcctgagtgg tcagaagtct ctgaggatgc caagcagctg      840

atccgcctcc tgttgaagac agaccccaca gagaggctga ccatcactca gttcatgaac      900

cacccctgga tcaaccaatc gatggtagtg ccacagaccc cactccacac ggcccgagtg      960

ctgcaggagg acaaagacca ctgggacgaa gtcaaggagg agatgaccag tgccttggcc     1020

actatgcggg tagactacga ccaggtgaag atcaaggacc tgaagacctc taacaaccgg     1080

ctcctcaaca agaggagaaa aaagcaggca ggcagctcct ctgcctcaca gggctgcaac     1140

aaccagtag                                                             1149


<210>  738
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Asp Gly Glu Thr Ala Glu Glu Gln Gly Gly Pro Val Pro Pro Pro 
1               5                   10                  15      


Val Ala Pro Gly Gly Pro Gly Leu Gly Gly Ala Pro Gly Gly Arg Arg 
            20                  25                  30          


Glu Pro Lys Lys Tyr Ala Val Thr Asp Asp Tyr Gln Leu Ser Lys Gln 
        35                  40                  45              


Val Leu Gly Leu Gly Val Asn Gly Lys Val Leu Glu Cys Phe His Arg 
    50                  55                  60                  


Arg Thr Gly Gln Lys Cys Ala Leu Lys Leu Leu Tyr Asp Ser Pro Lys 
65                  70                  75                  80  


Ala Arg Gln Glu Val Asp His His Trp Gln Ala Ser Gly Gly Pro His 
                85                  90                  95      


Ile Val Cys Ile Leu Asp Val Tyr Glu Asn Met His His Gly Lys Arg 
            100                 105                 110         


Cys Leu Leu Ile Ile Met Glu Cys Met Glu Gly Gly Glu Leu Phe Ser 
        115                 120                 125             


Arg Ile Gln Glu Arg Gly Asp Gln Ala Phe Thr Glu Arg Glu Ala Ala 
    130                 135                 140                 


Glu Ile Met Arg Asp Ile Gly Thr Ala Ile Gln Phe Leu His Ser His 
145                 150                 155                 160 


Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu Leu Tyr Thr Ser 
                165                 170                 175     


Lys Glu Lys Asp Ala Val Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys 
            180                 185                 190         


Glu Thr Thr Gln Asn Ala Leu Gln Thr Pro Cys Tyr Thr Pro Tyr Tyr 
        195                 200                 205             


Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr Asp Lys Ser Cys Asp 
    210                 215                 220                 


Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu Leu Cys Gly Phe Pro 
225                 230                 235                 240 


Pro Phe Tyr Ser Asn Thr Gly Gln Ala Ile Ser Pro Gly Met Lys Arg 
                245                 250                 255     


Arg Ile Arg Leu Gly Gln Tyr Gly Phe Pro Asn Pro Glu Trp Ser Glu 
            260                 265                 270         


Val Ser Glu Asp Ala Lys Gln Leu Ile Arg Leu Leu Leu Lys Thr Asp 
        275                 280                 285             


Pro Thr Glu Arg Leu Thr Ile Thr Gln Phe Met Asn His Pro Trp Ile 
    290                 295                 300                 


Asn Gln Ser Met Val Val Pro Gln Thr Pro Leu His Thr Ala Arg Val 
305                 310                 315                 320 


Leu Gln Glu Asp Lys Asp His Trp Asp Glu Val Lys Glu Glu Met Thr 
                325                 330                 335     


Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Asp Gln Val Lys Ile Lys 
            340                 345                 350         


Asp Leu Lys Thr Ser Asn Asn Arg Leu Leu Asn Lys Arg Arg Lys Lys 
        355                 360                 365             


Gln Ala Gly Ser Ser Ser Ala Ser Gln Gly Cys Asn Asn Gln 
    370                 375                 380         


<210>  739
<211>  521
<212>  DNA
<213>  Homo sapiens

<400>  739
atggcagtga acgtatactc aacgtcagtg accagtgata acctaagtcg acatgacatg       60

ctggcctgga tcaatgagtc tctgcagttg aatctgacaa agatcgaaca gttgtgctca      120

ggggctgcgt attgtcagtt tatggacatg ctgttccctg gctccattgc cttgaagaaa      180

gtgaaattcc aagctaagct agaacacgag tacatccaga acttcaaaat actacaagca      240

ggttttaaga gaatgggtgt tgacaaaata attcctgtgg acaaattagt aaaaggaaag      300

tttcaggaca attttgaatt cgttcagtgg ttcaagaagt ttttcgatgc aaactatgat      360

ggaaaagact atgaccctgt ggctgccaga caaggtcaag aaactgcagt ggctccttcc      420

cttgttgctc cagctctgaa taaaccgaag aaacctctca cttctagcag tgcagctccc      480

cagaggccca tctcaacaca gagaaccgct gctccccaaa t                          521


<210>  740
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
1               5                   10                  15      


Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
            20                  25                  30          


Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
        35                  40                  45              


Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln 
    50                  55                  60                  


Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
65                  70                  75                  80  


Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu 
                85                  90                  95      


Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys 
            100                 105                 110         


Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala 
        115                 120                 125             


Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro 
    130                 135                 140                 


Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro 
145                 150                 155                 160 


Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Pro Gln 
                165                 170             


<210>  741
<211>  1941
<212>  DNA
<213>  Homo sapiens

<400>  741
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag ccggggcgtg     1680

gtcatcgtgg ctgtgattgt gtgcatcctg gtcctggcgg tgctgggcgc tgtcctctat     1740

ttcctctata agaagggcaa gctgccgtgc aggcgctcag ggaagcagga gatcacgcta     1800

cccccgtctc gtaagagcga acttgtagtt gaagttaagt cagataagct cccagaagag     1860

atgggcctcc tgcagggcag cagcggtgac aagagggctc cgggagacca gggagagaaa     1920

tacatcgatc tgaggcatta g                                               1941


<210>  742
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  742

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  743
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  743
atgtcgtccc cggcgtcgac cccgagccgc cgcggcagcc ggcgtggaag ggccaccccc       60

gcccagacgc ctcggagtga ggatgccagg tcatctccct ctcagagacg tagaggcgag      120

gattccacct ccacggggga gttgcagccg atgccaacct cgcctggagt ggacctgcag      180

agccctgctg cgcaggacgt gctgttttcc agccctcccc aaatgcattc ttcagctatc      240

cctcttgact ttgatgttag ttcaccactg acatacggca ctcccagctc tcgggtagag      300

ggaaccccaa gaagtggtgt taggggcaca cctgtgagac agaggcctga cctgggctct      360

gcacagaagg gcctgcaagt ggatctgcag tctgacgggg cagcagcaga agatatagtg      420

gcaagtgagc agtctctagg ccaaaaactt gtgatctggg gaacagatgt aaatgtggca      480

gcatgcaaag aaaactttca gagatttctt cagcgtttta ttgaccctct ggctaaagaa      540

gaagaaaatg ttggcataga tattactgaa cctctataca tgcaacgact tggggagatt      600

aatgttattg gtgagccatt tttaaatgtg aactgtgaac acatcaaatc atttgacaaa      660

aatttgtaca gacaactcat ctcttaccca caggaagtta ttccaacttt tgacatggct      720

gtcaatgaaa tcttctttga ccgttaccct gactcaatct tagaacatca gattcaagta      780

agaccattca acgcattgaa gactaagaat atgagaaacc tgaatccaga agacattgac      840

cagctcatca ccatcagcgg catggtgatc aggacatccc agctgattcc cgagatgcag      900

gaggccttct tccagtgcca agtgtgtgcc cacacgaccc gggtggagat ggaccgcggc      960

cgcattgcag agcccagtgt gtgcgggcgc tgccacacca cccacagcat ggcactcatc     1020

cacaaccgct ccctcttctc tgacaagcag atgatcaagc ttcaggagtc tccggaagac     1080

atgcctgcag ggcagacacc acacacagtt atcctgtttg ctcacaatga tctcgttgac     1140

aaggtccagc ctggggacag agtgaatgtt acaggcatct atcgagctgt gcctattcga     1200

gtcaatccaa gagtgagtaa tgtgaagtct gtctacaaaa cccacattga tgtcattcat     1260

tatcggaaaa cggatgcaaa acgtctgcat ggccttgatg aagaagcaga acagaaactt     1320

ttttcagaga aacgtgtgga attgcttaag gaactttcca ggaaaccaga catttatgag     1380

aggcttgctt cagccttggc tccaagcatt tatgaacatg aagatataaa gaagggaatt     1440

ttgcttcagc tctttggcgg gacaaggaag gattttagtc acactggaag gggcaaattt     1500

cgggctgaga tcaacatctt gctgtgtggc gaccctggta ccagcaagtc ccagctgctg     1560

cagtacgtgt acaacctcgt ccccaggggc cagtacacgt ctgggaaggg ctccagtgca     1620

gttggcctca ctgcgtacgt aatgaaagac cctgagacaa ggcagctggt cctgcagaca     1680

ggtgctcttg tcctgagtga caacggcatc tgctgtatcg atgagttcga caagatgaat     1740

gaaagtacaa gatcggtatt gcatgaagtc atggaacagc agactctgtc cattgcaaag     1800

gctgggatca tctgtcagct caatgcgcgc acctctgtcc tggcagcagc aaatcccatt     1860

gagtctcagt ggaatcctaa aaaaacaacc attgaaaaca tccagctgcc tcatacttta     1920

ttatcaaggt ttgatttgat cttcctcttg ctggaccctc aggacgaagc ctatgacagg     1980

cgtctggctc accacctggt cgcactgtac taccagagcg aggagcaggc agaggaggag     2040

ctcctggaca tggcggtgct aaaggactac attgcctacg cgcacagcac catcatgccg     2100

cggctaagtg aggaagccag ccaggctctc atcgaggctt atgtagacat gaggaagatt     2160

ggcagtagcc ggggaatggt ttctgcatac cctcgacagc tagagtcatt aatccgctta     2220

gcagaagccc atgctaaagt aagattgtct aacaaagttg aagccattga tgtggaagag     2280

gccaaacgcc tccatcggga agctctgaag cagtctgcaa ctgatccccg gactggcatc     2340

gtggacatat ctattcttac tacggggatg agtgccacct ctcgtaaacg gaaagaagaa     2400

ttagctgaag cattgaaaaa gcttatttta tctaagggca aaacaccagc tctaaaatac     2460

cagcaacttt ttgaagatat tcggggacaa tctgacatag caattactaa agatatgttt     2520

gaagaagcac tgcgtgccct ggcagatgat gatttcctga cagtgactgg gaagaccgtg     2580

cgcttgctct ga                                                         2592


<210>  744
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  744

Met Ser Ser Pro Ala Ser Thr Pro Ser Arg Arg Gly Ser Arg Arg Gly 
1               5                   10                  15      


Arg Ala Thr Pro Ala Gln Thr Pro Arg Ser Glu Asp Ala Arg Ser Ser 
            20                  25                  30          


Pro Ser Gln Arg Arg Arg Gly Glu Asp Ser Thr Ser Thr Gly Glu Leu 
        35                  40                  45              


Gln Pro Met Pro Thr Ser Pro Gly Val Asp Leu Gln Ser Pro Ala Ala 
    50                  55                  60                  


Gln Asp Val Leu Phe Ser Ser Pro Pro Gln Met His Ser Ser Ala Ile 
65                  70                  75                  80  


Pro Leu Asp Phe Asp Val Ser Ser Pro Leu Thr Tyr Gly Thr Pro Ser 
                85                  90                  95      


Ser Arg Val Glu Gly Thr Pro Arg Ser Gly Val Arg Gly Thr Pro Val 
            100                 105                 110         


Arg Gln Arg Pro Asp Leu Gly Ser Ala Gln Lys Gly Leu Gln Val Asp 
        115                 120                 125             


Leu Gln Ser Asp Gly Ala Ala Ala Glu Asp Ile Val Ala Ser Glu Gln 
    130                 135                 140                 


Ser Leu Gly Gln Lys Leu Val Ile Trp Gly Thr Asp Val Asn Val Ala 
145                 150                 155                 160 


Ala Cys Lys Glu Asn Phe Gln Arg Phe Leu Gln Arg Phe Ile Asp Pro 
                165                 170                 175     


Leu Ala Lys Glu Glu Glu Asn Val Gly Ile Asp Ile Thr Glu Pro Leu 
            180                 185                 190         


Tyr Met Gln Arg Leu Gly Glu Ile Asn Val Ile Gly Glu Pro Phe Leu 
        195                 200                 205             


Asn Val Asn Cys Glu His Ile Lys Ser Phe Asp Lys Asn Leu Tyr Arg 
    210                 215                 220                 


Gln Leu Ile Ser Tyr Pro Gln Glu Val Ile Pro Thr Phe Asp Met Ala 
225                 230                 235                 240 


Val Asn Glu Ile Phe Phe Asp Arg Tyr Pro Asp Ser Ile Leu Glu His 
                245                 250                 255     


Gln Ile Gln Val Arg Pro Phe Asn Ala Leu Lys Thr Lys Asn Met Arg 
            260                 265                 270         


Asn Leu Asn Pro Glu Asp Ile Asp Gln Leu Ile Thr Ile Ser Gly Met 
        275                 280                 285             


Val Ile Arg Thr Ser Gln Leu Ile Pro Glu Met Gln Glu Ala Phe Phe 
    290                 295                 300                 


Gln Cys Gln Val Cys Ala His Thr Thr Arg Val Glu Met Asp Arg Gly 
305                 310                 315                 320 


Arg Ile Ala Glu Pro Ser Val Cys Gly Arg Cys His Thr Thr His Ser 
                325                 330                 335     


Met Ala Leu Ile His Asn Arg Ser Leu Phe Ser Asp Lys Gln Met Ile 
            340                 345                 350         


Lys Leu Gln Glu Ser Pro Glu Asp Met Pro Ala Gly Gln Thr Pro His 
        355                 360                 365             


Thr Val Ile Leu Phe Ala His Asn Asp Leu Val Asp Lys Val Gln Pro 
    370                 375                 380                 


Gly Asp Arg Val Asn Val Thr Gly Ile Tyr Arg Ala Val Pro Ile Arg 
385                 390                 395                 400 


Val Asn Pro Arg Val Ser Asn Val Lys Ser Val Tyr Lys Thr His Ile 
                405                 410                 415     


Asp Val Ile His Tyr Arg Lys Thr Asp Ala Lys Arg Leu His Gly Leu 
            420                 425                 430         


Asp Glu Glu Ala Glu Gln Lys Leu Phe Ser Glu Lys Arg Val Glu Leu 
        435                 440                 445             


Leu Lys Glu Leu Ser Arg Lys Pro Asp Ile Tyr Glu Arg Leu Ala Ser 
    450                 455                 460                 


Ala Leu Ala Pro Ser Ile Tyr Glu His Glu Asp Ile Lys Lys Gly Ile 
465                 470                 475                 480 


Leu Leu Gln Leu Phe Gly Gly Thr Arg Lys Asp Phe Ser His Thr Gly 
                485                 490                 495     


Arg Gly Lys Phe Arg Ala Glu Ile Asn Ile Leu Leu Cys Gly Asp Pro 
            500                 505                 510         


Gly Thr Ser Lys Ser Gln Leu Leu Gln Tyr Val Tyr Asn Leu Val Pro 
        515                 520                 525             


Arg Gly Gln Tyr Thr Ser Gly Lys Gly Ser Ser Ala Val Gly Leu Thr 
    530                 535                 540                 


Ala Tyr Val Met Lys Asp Pro Glu Thr Arg Gln Leu Val Leu Gln Thr 
545                 550                 555                 560 


Gly Ala Leu Val Leu Ser Asp Asn Gly Ile Cys Cys Ile Asp Glu Phe 
                565                 570                 575     


Asp Lys Met Asn Glu Ser Thr Arg Ser Val Leu His Glu Val Met Glu 
            580                 585                 590         


Gln Gln Thr Leu Ser Ile Ala Lys Ala Gly Ile Ile Cys Gln Leu Asn 
        595                 600                 605             


Ala Arg Thr Ser Val Leu Ala Ala Ala Asn Pro Ile Glu Ser Gln Trp 
    610                 615                 620                 


Asn Pro Lys Lys Thr Thr Ile Glu Asn Ile Gln Leu Pro His Thr Leu 
625                 630                 635                 640 


Leu Ser Arg Phe Asp Leu Ile Phe Leu Leu Leu Asp Pro Gln Asp Glu 
                645                 650                 655     


Ala Tyr Asp Arg Arg Leu Ala His His Leu Val Ala Leu Tyr Tyr Gln 
            660                 665                 670         


Ser Glu Glu Gln Ala Glu Glu Glu Leu Leu Asp Met Ala Val Leu Lys 
        675                 680                 685             


Asp Tyr Ile Ala Tyr Ala His Ser Thr Ile Met Pro Arg Leu Ser Glu 
    690                 695                 700                 


Glu Ala Ser Gln Ala Leu Ile Glu Ala Tyr Val Asp Met Arg Lys Ile 
705                 710                 715                 720 


Gly Ser Ser Arg Gly Met Val Ser Ala Tyr Pro Arg Gln Leu Glu Ser 
                725                 730                 735     


Leu Ile Arg Leu Ala Glu Ala His Ala Lys Val Arg Leu Ser Asn Lys 
            740                 745                 750         


Val Glu Ala Ile Asp Val Glu Glu Ala Lys Arg Leu His Arg Glu Ala 
        755                 760                 765             


Leu Lys Gln Ser Ala Thr Asp Pro Arg Thr Gly Ile Val Asp Ile Ser 
    770                 775                 780                 


Ile Leu Thr Thr Gly Met Ser Ala Thr Ser Arg Lys Arg Lys Glu Glu 
785                 790                 795                 800 


Leu Ala Glu Ala Leu Lys Lys Leu Ile Leu Ser Lys Gly Lys Thr Pro 
                805                 810                 815     


Ala Leu Lys Tyr Gln Gln Leu Phe Glu Asp Ile Arg Gly Gln Ser Asp 
            820                 825                 830         


Ile Ala Ile Thr Lys Asp Met Phe Glu Glu Ala Leu Arg Ala Leu Ala 
        835                 840                 845             


Asp Asp Asp Phe Leu Thr Val Thr Gly Lys Thr Val Arg Leu Leu 
    850                 855                 860             


<210>  745
<211>  2466
<212>  DNA
<213>  Homo sapiens

<400>  745
atggacctcg cggcggcagc ggagccgggc gccggcagcc agcacctgga ggtccgcgac       60

gaggtggccg agaagtgcca gaaactgttc ctggacttct tggaggagtt tcagagcagc      120

gatggagaaa ttaaatactt gcaattagca gaggaactga ttcgtcctga gagaaacaca      180

ttggttgtga gttttgtgga cctggaacaa tttaaccagc aactttccac caccattcaa      240

gaggagttct atagagttta cccttacctg tgtcgggcct tgaaaacatt cgtcaaagac      300

cgtaaagaga tccctcttgc caaggatttt tatgttgcat tccaagacct gcctaccaga      360

cacaagattc gagagctcac ctcatccaga attggtttgc tcactcgcat cagtgggcag      420

gtggtgcgga ctcacccagt tcacccagag cttgtgagcg gaacttttct gtgcttggac      480

tgtcagacag tgatcaggga tgtagaacag cagttcaaat acacacagcc aaacatctgc      540

cgaaatccag tttgtgccaa caggaggaga ttcttactgg atacaaataa atcaagattt      600

gttgattttc aaaaggttcg tattcaagag acccaagctg agcttcctcg agggagtatc      660

ccccgcagtt tagaagtaat tttaagggct gaagctgtgg aatcagctca agctggtgac      720

aagtgtgact ttacagggac actgattgtt gtgcctgacg tctccaagct tagcacacca      780

ggagcacgtg cagaaactaa ttcccgtgtc agtggtgttg atggatatga gacagaaggc      840

attcgaggac tccgggccct tggtgttagg gacctttctt ataggctggt ctttcttgcc      900

tgctgtgttg cgccaaccaa cccaaggttt ggggggaaag agctcagaga tgaggaacag      960

acagctgaga gcattaagaa ccaaatgact gtgaaagaat gggagaaagt gtttgagatg     1020

agtcaagata aaaatctata ccacaatctt tgtaccagcc tgttccctac tatacatggc     1080

aatgatgaag taaaacgggg tgtcctgctg atgctctttg gtggcgttcc aaagacaaca     1140

ggagaaggga cctctcttcg aggggacata aatgtttgca ttgttggtga cccaagtaca     1200

gctaagagcc aatttctcaa gcacgtggag gagttcagcc ccagagctgt ctacaccagt     1260

ggtaaagcgt ccagtgctgc tggcttaaca gcagctgttg tgagagatga agaatctcat     1320

gagtttgtca ttgaggctgg agctttgatg ttggctgata atggtgtgtg ttgtattgat     1380

gaatttgata agatggacgt gcgggatcaa gttgctattc atgaagctat ggaacagcag     1440

accatatcca tcactaaagc aggagtgaag gctactctga acgcccggac gtccattttg     1500

gcagcagcaa acccaatcag tggacactat gacagatcaa aatcattgaa acagaatata     1560

aatttgtcag ctcccatcat gtcccgattc gatctcttct ttatccttgt ggatgaatgt     1620

aatgaggtta cagattatgc cattgccagg cgcatagtag atttgcattc aagaattgag     1680

gaatcaattg atcgtgtcta ttccctcgat gatatcagaa gatatcttct ctttgcaaga     1740

cagtttaaac ccaagatttc caaagagtca gaggacttca ttgtggagca atataaacat     1800

ctccgccaga gagatggttc tggagtgacc aagtcttcat ggaggattac agtgcgacag     1860

cttgagagca tgattcgtct ctctgaagct atggctcgga tgcactgctg tgatgaggtc     1920

caacctaaac atgtgaagga agctttccgg ttactgaata aatcaatcat ccgtgtggaa     1980

acacctgatg tcaatctaga tcaagaggaa gagatccaga tggaggtaga tgagggtgct     2040

ggtggcatca atggtcatgc tgacagccct gctcctgtga acgggatcaa tggctacaat     2100

gaagacataa atcaagagtc tgctcccaaa gcctccttaa ggctgggctt ctctgagtac     2160

tgccgaatct ctaaccttat tgtgcttcac ctcagaaagg tggaagaaga agaggacgag     2220

tcagcattaa agaggagcga gcttgttaac tggtacttga aggaaatcga atcagagata     2280

gactctgaag aagaacttat aaataaaaaa agaatcatag agaaagttat tcatcgactc     2340

acacactatg atcatgttct aattgagctc acccaggctg gattgaaagg ctccacagag     2400

ggaagtgaga gctatgaaga agatccctac ttggtagtta accctaacta cttgctcgaa     2460

gattga                                                                2466


<210>  746
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 
1               5                   10                  15      


Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 
            20                  25                  30          


Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 
        35                  40                  45              


Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 
    50                  55                  60                  


Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 
65                  70                  75                  80  


Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 
                85                  90                  95      


Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 
            100                 105                 110         


Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 
        115                 120                 125             


Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 
    130                 135                 140                 


His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 
145                 150                 155                 160 


Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 
                165                 170                 175     


Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 
        195                 200                 205             


Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 
    210                 215                 220                 


Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 
225                 230                 235                 240 


Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 
                245                 250                 255     


Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 
            260                 265                 270         


Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 
        275                 280                 285             


Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 
    290                 295                 300                 


Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 
305                 310                 315                 320 


Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 
                325                 330                 335     


Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 
            340                 345                 350         


Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 
        355                 360                 365             


Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 
    370                 375                 380                 


Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 
385                 390                 395                 400 


Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 
                405                 410                 415     


Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 
            420                 425                 430         


Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 
        435                 440                 445             


Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 
    450                 455                 460                 


Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 
465                 470                 475                 480 


Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 
                485                 490                 495     


Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 
            500                 505                 510         


Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 
        515                 520                 525             


Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 
    530                 535                 540                 


Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 
545                 550                 555                 560 


Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 
                565                 570                 575     


Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 
            580                 585                 590         


Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 
        595                 600                 605             


Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 
    610                 615                 620                 


Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 
625                 630                 635                 640 


Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 
                645                 650                 655     


Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 
            660                 665                 670         


Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 
        675                 680                 685             


Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 
    690                 695                 700                 


Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 
705                 710                 715                 720 


Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 
                725                 730                 735     


Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 
            740                 745                 750         


Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 
        755                 760                 765             


Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 
    770                 775                 780                 


His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 
785                 790                 795                 800 


Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 
                805                 810                 815     


Tyr Leu Leu Glu Asp 
            820     


<210>  747
<211>  882
<212>  DNA
<213>  Homo sapiens

<400>  747
atggcgactt tttctggccc ggctgggcca atcctgtcgc ttaatccgca ggaagatgtc       60

gagtttcaaa aggaggtggc gcaggttcgc aagcgcataa cccagcgaaa aaaacaagaa      120

caacttactc ctggagtagt ctatgtgcgc cacctaccta acctacttga cgaaacccag      180

atcttttcat atttctccca gtttggcact gtgacacggt tcaggctgtc cagaagtaaa      240

aggactggaa atagcaaagg ctatgcattt gtggagtttg agtctgagga tgttgccaaa      300

atagttgctg aaacaatgaa caactacctg tttggtgaaa gactcttgga gtgtcatttt      360

atgccacctg aaaaagtaca taaagaactc tttaaagact ggaatattcc atttaagcag      420

ccatcatatc catcagtgaa acggtataat cggaatcgga cactaacaca aaagctacgg      480

atggaggagc gatttaaaaa gaaagaaaga ttactcagga agaaattagc taaaaaagga      540

attgactatg attttccttc tttgatttta cagaaaacgg aaagtatttc aaaaactaat      600

cgtcagacgt ctacaaaagg ccaggtttta cgtaagaaga agaaaaaagt ttcaggtact      660

cttgacactc ctgagaagac tgtggatagc cagggcccca caccagtttg tacaccaaca      720

tttttggaga ggcgaaaatc tcaagtggct gaactgaatg atgatgataa agatgatgaa      780

atagttttca aacagcccat atcctgtgta aaagaagaaa tacaagagac tcaaacacct      840

acacattcac ggaaaaaaag acgaagaagc agcaatcagt ga                         882


<210>  748
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Ala Thr Phe Ser Gly Pro Ala Gly Pro Ile Leu Ser Leu Asn Pro 
1               5                   10                  15      


Gln Glu Asp Val Glu Phe Gln Lys Glu Val Ala Gln Val Arg Lys Arg 
            20                  25                  30          


Ile Thr Gln Arg Lys Lys Gln Glu Gln Leu Thr Pro Gly Val Val Tyr 
        35                  40                  45              


Val Arg His Leu Pro Asn Leu Leu Asp Glu Thr Gln Ile Phe Ser Tyr 
    50                  55                  60                  


Phe Ser Gln Phe Gly Thr Val Thr Arg Phe Arg Leu Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Thr Gly Asn Ser Lys Gly Tyr Ala Phe Val Glu Phe Glu Ser Glu 
                85                  90                  95      


Asp Val Ala Lys Ile Val Ala Glu Thr Met Asn Asn Tyr Leu Phe Gly 
            100                 105                 110         


Glu Arg Leu Leu Glu Cys His Phe Met Pro Pro Glu Lys Val His Lys 
        115                 120                 125             


Glu Leu Phe Lys Asp Trp Asn Ile Pro Phe Lys Gln Pro Ser Tyr Pro 
    130                 135                 140                 


Ser Val Lys Arg Tyr Asn Arg Asn Arg Thr Leu Thr Gln Lys Leu Arg 
145                 150                 155                 160 


Met Glu Glu Arg Phe Lys Lys Lys Glu Arg Leu Leu Arg Lys Lys Leu 
                165                 170                 175     


Ala Lys Lys Gly Ile Asp Tyr Asp Phe Pro Ser Leu Ile Leu Gln Lys 
            180                 185                 190         


Thr Glu Ser Ile Ser Lys Thr Asn Arg Gln Thr Ser Thr Lys Gly Gln 
        195                 200                 205             


Val Leu Arg Lys Lys Lys Lys Lys Val Ser Gly Thr Leu Asp Thr Pro 
    210                 215                 220                 


Glu Lys Thr Val Asp Ser Gln Gly Pro Thr Pro Val Cys Thr Pro Thr 
225                 230                 235                 240 


Phe Leu Glu Arg Arg Lys Ser Gln Val Ala Glu Leu Asn Asp Asp Asp 
                245                 250                 255     


Lys Asp Asp Glu Ile Val Phe Lys Gln Pro Ile Ser Cys Val Lys Glu 
            260                 265                 270         


Glu Ile Gln Glu Thr Gln Thr Pro Thr His Ser Arg Lys Lys Arg Arg 
        275                 280                 285             


Arg Ser Ser Asn Gln 
    290             


<210>  749
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  749
atgggccgcg gggcccgtgt cccctcggag gccccggggg caggcgtcga gcgccgctgg       60

cttggagccg cgctggtcgc cctgtgcctc ctccccgcgc tggtgctgct ggcccggctg      120

ggggccccgg cggtgccggc ctggagcgca gcgcagggag acgtcgctgc gctgggcctc      180

tcggcggtcc cccccacccg ggtcccgggc ccactggccc cccgcagacg ccgctacacg      240

ctgactccag ccaggctgcg ctgggaccac ttcaacctca cctacaggat cctctccttc      300

ccgcggaacc tgctgagccc gcgggagacg cggcgggccc tagctgccgc cttccgcatg      360

tggagcgacg tgtccccctt cagcttccgc gaggtggccc ccgagcagcc cagcgacctc      420

cggataggct tctacccgat caaccacacg gactgcctgg tctccgcgct gcaccactgc      480

ttcgacggcc ccacggggga gctggcccac gccttcttcc ccccgcacgg cggcatccac      540

ttcgacgaca gcgagtactg ggtcctgggc cccacgcgct acagctggaa gaaaggcgtg      600

tggctcacgg acctggtgca cgtggcggcc cacgagatcg gccacgcgct gggcctgatg      660

cactcacaac acggccgggc gctcatgcac ctgaacgcca cgctgcgcgg ctggaaggcg      720

ttgtcccagg acgagctgtg ggggctgcac cggctctacg gatgcctcga caggctgttc      780

gtgtgcgcgt cctgggcgcg gaggggcttc tgcgacgctc gccggcggct catgaagagg      840

ctctgcccca gcagctgcga cttctgctac gaattcccct tccccacggt ggccaccacc      900

ccaccgcccc ccaggaccaa aaccaggctg gtgcccgagg gcaggaacgt gaccttccgc      960

tgcggccaga agatcctcca caagaaaggg aaagtgtact ggtacaagga ccaggagccc     1020

ctggagttct cctaccccgg ctacctggcc ctgggcgagg cgcacctgag catcatcgcc     1080

aacgccgtca atgagggcac ctacacctgc gtggtgcgcc gccagcagcg cgtgctgacc     1140

acctactcct ggcgagtccg tgtgcggggc tga                                  1173


<210>  750
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Gly Arg Gly Ala Arg Val Pro Ser Glu Ala Pro Gly Ala Gly Val 
1               5                   10                  15      


Glu Arg Arg Trp Leu Gly Ala Ala Leu Val Ala Leu Cys Leu Leu Pro 
            20                  25                  30          


Ala Leu Val Leu Leu Ala Arg Leu Gly Ala Pro Ala Val Pro Ala Trp 
        35                  40                  45              


Ser Ala Ala Gln Gly Asp Val Ala Ala Leu Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Pro Thr Arg Val Pro Gly Pro Leu Ala Pro Arg Arg Arg Arg Tyr Thr 
65                  70                  75                  80  


Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr Arg 
                85                  90                  95      


Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr Arg Arg 
            100                 105                 110         


Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe Ser 
        115                 120                 125             


Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile Gly Phe 
    130                 135                 140                 


Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His His Cys 
145                 150                 155                 160 


Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro His 
                165                 170                 175     


Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro Thr 
            180                 185                 190         


Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His Val 
        195                 200                 205             


Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln His 
    210                 215                 220                 


Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys Ala 
225                 230                 235                 240 


Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys Leu 
                245                 250                 255     


Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe Cys Asp 
            260                 265                 270         


Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys Asp Phe 
        275                 280                 285             


Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro Pro Pro 
    290                 295                 300                 


Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr Phe Arg 
305                 310                 315                 320 


Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr Lys 
                325                 330                 335     


Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu Gly 
            340                 345                 350         


Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr Tyr 
        355                 360                 365             


Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr Ser Trp 
    370                 375                 380                 


Arg Val Arg Val Arg Gly 
385                 390 


<210>  751
<211>  2805
<212>  DNA
<213>  Homo sapiens

<400>  751
atggcggtgc agccgaagga gacgctgcag ttggagagcg cggccgaggt cggcttcgtg       60

cgcttctttc agggcatgcc ggagaagccg accaccacag tgcgcctttt cgaccggggc      120

gacttctata cggcgcacgg cgaggacgcg ctgctggccg cccgggaggt gttcaagacc      180

cagggggtga tcaagtacat ggggccggca ggagcaaaga atctgcagag tgttgtgctt      240

agtaaaatga attttgaatc ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt      300

gaagtttata agaatagagc tggaaataag gcatccaagg agaatgattg gtatttggca      360

tataaggctt ctcctggcaa tctctctcag tttgaagaca ttctctttgg taacaatgat      420

atgtcagctt ccattggtgt tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag      480

gttggagttg ggtatgtgga ttccatacag aggaaactag gactgtgtga attccctgat      540

aatgatcagt tctccaatct tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt      600

ttacccggag gagagactgc tggagacatg gggaaactga gacagataat tcaaagagga      660

ggaattctga tcacagaaag aaaaaaagct gacttttcca caaaagacat ttatcaggac      720

ctcaaccggt tgttgaaagg caaaaaggga gagcagatga atagtgctgt attgccagaa      780

atggagaatc aggttgcagt ttcatcactg tctgcggtaa tcaagttttt agaactctta      840

tcagatgatt ccaactttgg acagtttgaa ctgactactt ttgacttcag ccagtatatg      900

aaattggata ttgcagcagt cagagccctt aacctttttc agggttctgt tgaagatacc      960

actggctctc agtctctggc tgccttgctg aataagtgta aaacccctca aggacaaaga     1020

cttgttaacc agtggattaa gcagcctctc atggataaga acagaataga ggagagattg     1080

aatttagtgg aagcttttgt agaagatgca gaattgaggc agactttaca agaagattta     1140

cttcgtcgat tcccagatct taaccgactt gccaagaagt ttcaaagaca agcagcaaac     1200

ttacaagatt gttaccgact ctatcagggt ataaatcaac tacctaatgt tatacaggct     1260

ctggaaaaac atgaaggaaa acaccagaaa ttattgttgg cagtttttgt gactcctctt     1320

actgatcttc gttctgactt ctccaagttt caggaaatga tagaaacaac tttagatatg     1380

gatcaggtgg aaaaccatga attccttgta aaaccttcat ttgatcctaa tctcagtgaa     1440

ttaagagaaa taatgaatga cttggaaaag aagatgcagt caacattaat aagtgcagcc     1500

agagatcttg gcttggaccc tggcaaacag attaaactgg attccagtgc acagtttgga     1560

tattactttc gtgtaacctg taaggaagaa aaagtccttc gtaacaataa aaactttagt     1620

actgtagata tccagaagaa tggtgttaaa tttaccaaca gcaaattgac ttctttaaat     1680

gaagagtata ccaaaaataa aacagaatat gaagaagccc aggatgccat tgttaaagaa     1740

attgtcaata tttcttcagg ctatgtagaa ccaatgcaga cactcaatga tgtgttagct     1800

cagctagatg ctgttgtcag ctttgctcac gtgtcaaatg gagcacctgt tccatatgta     1860

cgaccagcca ttttggagaa aggacaagga agaattatat taaaagcatc caggcatgct     1920

tgtgttgaag ttcaagatga aattgcattt attcctaatg acgtatactt tgaaaaagat     1980

aaacagatgt tccacatcat tactggcccc aatatgggag gtaaatcaac atatattcga     2040

caaactgggg tgatagtact catggcccaa attgggtgtt ttgtgccatg tgagtcagca     2100

gaagtgtcca ttgtggactg catcttagcc cgagtagggg ctggtgacag tcaattgaaa     2160

ggagtctcca cgttcatggc tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc     2220

aaagattcat taataatcat agatgaattg ggaagaggaa cttctaccta cgatggattt     2280

gggttagcat gggctatatc agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt     2340

gcaacccatt ttcatgaact tactgccttg gccaatcaga taccaactgt taataatcta     2400

catgtcacag cactcaccac tgaagagacc ttaactatgc tttatcaggt gaagaaaggt     2460

gtctgtgatc aaagttttgg gattcatgtt gcagagcttg ctaatttccc taagcatgta     2520

atagagtgtg ctaaacagaa agccctggaa cttgaggagt ttcagtatat tggagaatcg     2580

caaggatatg atatcatgga accagcagca aagaagtgct atctggaaag agagcaaggt     2640

gaaaaaatta ttcaggagtt cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca     2700

gaagaaaaca tcacaataaa gttaaaacag ctaaaagctg aagtaatagc aaagaataat     2760

agctttgtaa atgaaatcat ttcacgaata aaagttacta cgtga                     2805


<210>  752
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 
1               5                   10                  15      


Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr 
            20                  25                  30          


Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His Gly Glu 
        35                  40                  45              


Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr Gln Gly Val Ile 
    50                  55                  60                  


Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn Leu Gln Ser Val Val Leu 
65                  70                  75                  80  


Ser Lys Met Asn Phe Glu Ser Phe Val Lys Asp Leu Leu Leu Val Arg 
                85                  90                  95      


Gln Tyr Arg Val Glu Val Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 
            100                 105                 110         


Lys Glu Asn Asp Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 
        115                 120                 125             


Ser Gln Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 
    130                 135                 140                 


Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly Leu Cys 
                165                 170                 175     


Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu Ala Leu Leu Ile 
            180                 185                 190         


Gln Ile Gly Pro Lys Glu Cys Val Leu Pro Gly Gly Glu Thr Ala Gly 
        195                 200                 205             


Asp Met Gly Lys Leu Arg Gln Ile Ile Gln Arg Gly Gly Ile Leu Ile 
    210                 215                 220                 


Thr Glu Arg Lys Lys Ala Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 
225                 230                 235                 240 


Leu Asn Arg Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 
                245                 250                 255     


Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 
            260                 265                 270         


Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln 
        275                 280                 285             


Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu Asp Ile 
    290                 295                 300                 


Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser Val Glu Asp Thr 
305                 310                 315                 320 


Thr Gly Ser Gln Ser Leu Ala Ala Leu Leu Asn Lys Cys Lys Thr Pro 
                325                 330                 335     


Gln Gly Gln Arg Leu Val Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 
            340                 345                 350         


Lys Asn Arg Ile Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 
        355                 360                 365             


Asp Ala Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 
    370                 375                 380                 


Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 
385                 390                 395                 400 


Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro Asn 
                405                 410                 415     


Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln Lys Leu Leu 
            420                 425                 430         


Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu Arg Ser Asp Phe Ser 
        435                 440                 445             


Lys Phe Gln Glu Met Ile Glu Thr Thr Leu Asp Met Asp Gln Val Glu 
    450                 455                 460                 


Asn His Glu Phe Leu Val Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 
465                 470                 475                 480 


Leu Arg Glu Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 
                485                 490                 495     


Ile Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 
            500                 505                 510         


Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 
        515                 520                 525             


Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp Ile 
    530                 535                 540                 


Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr Ser Leu Asn 
545                 550                 555                 560 


Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala 
                565                 570                 575     


Ile Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met 
            580                 585                 590         


Gln Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 
        595                 600                 605             


Ala His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 
    610                 615                 620                 


Leu Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 
625                 630                 635                 640 


Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr 
                645                 650                 655     


Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met 
            660                 665                 670         


Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met 
        675                 680                 685             


Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile 
    690                 695                 700                 


Val Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys 
705                 710                 715                 720 


Gly Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 
                725                 730                 735     


Arg Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 
            740                 745                 750         


Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 
        755                 760                 765             


Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe 
    770                 775                 780                 


His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu 
785                 790                 795                 800 


His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln 
                805                 810                 815     


Val Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu 
            820                 825                 830         


Leu Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala 
        835                 840                 845             


Leu Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 
    850                 855                 860                 


Ile Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 
865                 870                 875                 880 


Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 
                885                 890                 895     


Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys 
            900                 905                 910         


Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser 
        915                 920                 925             


Arg Ile Lys Val Thr Thr 
    930                 


<210>  753
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  753
cgggcaatgc tgtgagagcc attggaagac tgtcctctat ggcaatgatc tcagggctca       60

gtggcaggaa atcctcaaca gggtcaccaa ccagcccgct caatgcagaa aaactagaat      120

ctgaagaaga tgtgtcccaa gctttccttg aggctgttgc tgaggaaaag cctcatgtaa      180

aaccctattt ctctaagacc attcgcgatt tagaagttgt ggagggaagt gctgctagat      240

ttgactgcaa gattgaagga tacccagacc ccgaggttgt ctggttcaaa gatgaccagt      300

caatcaggga gtcccgccac ttccagatag actacgatga ggacgggaac tgctctttaa      360

ttattagtga tgtttgcggg gatgacgatg ccaagtacac ctgcaaggct gtcaacagtc      420

ttggagaagc cacctgcaca gcagagctca ttgtggaaac gatggaggaa ggtgaagggg      480

aaggggaaga ggaagaagag tga                                              503


<210>  754
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  754

Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile 
1               5                   10                  15      


Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro 
            20                  25                  30          


Leu Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe 
        35                  40                  45              


Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser 
    50                  55                  60                  


Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe 
65                  70                  75                  80  


Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys 
                85                  90                  95      


Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp 
            100                 105                 110         


Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp 
        115                 120                 125             


Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr 
    130                 135                 140                 


Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu 
145                 150                 155                 160 


Gly Glu Glu Glu Glu Glu 
                165     


<210>  755
<211>  3858
<212>  DNA
<213>  Homo sapiens

<400>  755
atggaggatg gaaagcccgt ttgggcgcca caccctacag atggatttca gatgggcaat       60

attgtggata ttggccccga cagcttaaca attgaaccct tgaatcagaa aggcaagaca      120

tttttggctc tcataaacca agtgtttcct gcagaagagg acagtaaaaa agatgtggaa      180

gataactgtt cactaatgta tttaaatgaa gccacactgc tccataatat caaagttcga      240

tatagtaaag acagaattta tacatatgtc gccaacattc tgattgcagt gaatccatac      300

tttgacatac ctaaaatata ttcttcagaa gcaataaagt catatcaagg aaaatctctt      360

gggacaagac cacctcatgt ctttgcaatt gctgataaag cttttcgaga catgaaggtg      420

ctcaagatga gtcagtctat cattgtatct ggagaatcag gagccggcaa aacagaaaat      480

acaaaatttg ttctaagata cctgactgaa tcctatggaa caggtcaaga tattgatgac      540

agaattgttg aagctaaccc actcctagaa gcctttggaa atgcgaagac tgttcgcaac      600

aataatagca gtcgatttgg gaaatttgta gaaatacatt ttaatgaaaa gagctcagtt      660

gttggaggat ttgtttcaca ttatctccta gagaaatcta ggatctgtgt tcaaggcaaa      720

gaggaaagaa attatcatat cttttatagg ttgtgtgctg gtgcttctga agatattaga      780

gaaaaacttc atttgagttc accagataat tttcggtatt taaaccgagg ctgcactaga      840

tactttgcta acaaagaaac tgacaaacag attttacaga accgcaaaag tcctgagtac      900

cttaaggcag gttctatgaa agatcctctg ctagatgacc atggtgattt tattagaatg      960

tgcacggcta tgaaaaaaat tggtttggat gatgaagaaa agcttgatct cttccgggta     1020

gtagctggcg tcctgcacct tggaaatatt gattttgagg aagctggcag cacttcaggt     1080

ggttgtaatc tgaagaataa atctgctcag tctttggaat attgtgctga attactgggt     1140

ttggaccaag atgatcttcg agtaagtttg accacaagag tcatgctaac aacagcaggg     1200

ggcaccaaag gaacagttat aaaggtacct ctgaaagtgg agcaagcaaa caatgctcgt     1260

gatgccctgg caaagacagt gtatagccat ctttttgatc atgtggtaaa cagagtaaat     1320

cagtgttttc cttttgaaac atcatcctat tttattggag tcctagatat tgctggtttt     1380

gagtactttg agcataacag ttttgaacaa ttttgcatca actattgcaa tgaaaaactt     1440

caacaatttt ttaatgaaag gattctgaag gaggaacaag aactctatca aaaagaaggt     1500

ttaggtgtta atgaagtgca ttatgtggat aatcaggact gtatagattt aattgaagcc     1560

aaattagtgg gaatactgga tattttggat gaagaaaatc gccttcccca gccaagtgat     1620

caacacttta catctgcagt tcaccaaaag cacaaggatc attttcgact cactattccc     1680

agaaaatcta agctggcagt tcataggaat atcagagacg acgaaggctt cattatcagg     1740

cattttgcgg gggcagtgtg ctatgaaaca acccagtttg tggagaaaaa taatgatgct     1800

ttacatatgt ctcttgaatc cttaatatgt gaatccagag ataagtttat acgggaatta     1860

tttgaatcat ccacaaataa caacaaagat actaaacaaa aagcaggaaa acttagcttc     1920

atcagcgtgg gaaacaagtt taagacacag ttaaatttgc ttctggataa acttcgaagt     1980

actggagcaa gctttattcg ttgcatcaaa cctaacttaa agatgacaag ccaccacttt     2040

gaaggtgctc aaattctgtc tcagcttcag tgttcaggga tggtgtctgt tttggacttg     2100

atgcagggtg gttacccatc acgagcttca tttcatgaac tctacaacat gtacaaaaag     2160

tatatgccag ataaacttgc aagattggat ccaagactat tttgtaaggc tttgtttaaa     2220

gctttgggct taaatgaaaa tgactacaag tttgggttaa ccaaagtatt ttttagacct     2280

ggcaagtttg cagaatttga tcagatcatg aagtctgacc ctgaccactt agcagagttg     2340

gttaaaagag tcaatcactg gctcacatgc agtcgctgga agaaagttca gtggtgctca     2400

ctctcagtca tcaaattgaa aaacaaaata aaatatcgag ctgaagcctg cattaaaatg     2460

caaaaaacta ttcgaatgtg gctttgcaag aggagacaca aacctcgcat tgatggtctg     2520

gttaaggtgg gcacactgaa aaaacgactt gataaattta atgaggtagt cagtgtgttg     2580

aaagatggaa aacccgagat gaataaacag atcaagaatc tggaaatttc tattgatact     2640

ttgatggcca aaattaagtc cactatgatg acgcaggaac aaatccagaa agaatatgat     2700

gcactggtta aaagctcaga ggaactcctc agtgcattac agaaaaaaaa acagcaggaa     2760

gaggaagcag aaaggctgag gcgtattcaa gaagaaatgg aaaaggaaag aaaaagacgt     2820

gaagaagacg aaaaacgtcg aagaaaggaa gaggaggaaa ggcggatgaa acttgagatg     2880

gaagcaaaga gaaaacaaga agaagaagag agaaagaaaa gggaagatga tgaaaaacgc     2940

attcaagctg aagtggaggc acagctggcc cgacagaagg aggaggaatc ccaacagcaa     3000

gcagttctgg agcaggagcg cagggaccgg gagctggccc tgaggattgc ccagagtgaa     3060

gccgagctca tcagtgatga ggcccaggcc gacctggcgc tgcggagaaa tgatggaaca     3120

agacccaaaa tgacaccgga acaaatggcc aaagaaatgt cagaattttt gagtagaggt     3180

cctgctgtac tagccaccaa agcagctgct ggtactaaga aatatgatct tagtaaatgg     3240

aaatatgcag aactacgtga taccatcaat acttcttgtg atattgagct cctggcagct     3300

tgcagagaag aatttcatag gagactaaaa gtgtatcatg cttggaaatc taagaacaag     3360

aagagaaata ctgaaacaga gcaacgtgct ccaaagtctg ttactgatta tgattttgca     3420

ccatttttga acaattcacc tcagcaaaac ccagcagctc agattcctgc caggcagcgg     3480

gagattgaaa tgaaccgaca gcaacgcttc ttccgcatcc cattcatccg ccctgccgac     3540

cagtacaaag accctcagag taagaaaaaa ggctggtggt atgcccattt tgatggacca     3600

tggattgccc ggcaaatgga actccatcct gacaagccac ccatcctact tgtggctggt     3660

aaggacgaca tggagatgtg tgagctgaat cttgaggaga ctggcctgac tcggaagcgt     3720

ggtgctgaga tcttgccaag acagtttgaa gaaatctggg aacgctgtgg aggcatccag     3780

taccttcaga atgcgattga gagcagacag gctcggccca cctatgcaac agccatgctg     3840

cagagtctgt taaagtag                                                   3858


<210>  756
<211>  1285
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe 
1               5                   10                  15      


Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu 
            20                  25                  30          


Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val 
        35                  40                  45              


Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser 
    50                  55                  60                  


Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg 
65                  70                  75                  80  


Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala 
                85                  90                  95      


Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile 
            100                 105                 110         


Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe 
        115                 120                 125             


Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser 
    130                 135                 140                 


Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn 
145                 150                 155                 160 


Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln 
                165                 170                 175     


Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe 
            180                 185                 190         


Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys 
        195                 200                 205             


Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe 
    210                 215                 220                 


Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys 
225                 230                 235                 240 


Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser 
                245                 250                 255     


Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg 
            260                 265                 270         


Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp 
        275                 280                 285             


Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly 
    290                 295                 300                 


Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met 
305                 310                 315                 320 


Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp 
                325                 330                 335     


Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe 
            340                 345                 350         


Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser 
        355                 360                 365             


Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp 
    370                 375                 380                 


Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly 
385                 390                 395                 400 


Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala 
                405                 410                 415     


Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe 
            420                 425                 430         


Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser 
        435                 440                 445             


Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu 
    450                 455                 460                 


His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu 
465                 470                 475                 480 


Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr 
                485                 490                 495     


Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln 
            500                 505                 510         


Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile 
        515                 520                 525             


Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr 
    530                 535                 540                 


Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro 
545                 550                 555                 560 


Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly 
                565                 570                 575     


Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln 
            580                 585                 590         


Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu 
        595                 600                 605             


Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser 
    610                 615                 620                 


Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe 
625                 630                 635                 640 


Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp 
                645                 650                 655     


Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn 
            660                 665                 670         


Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln 
        675                 680                 685             


Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly 
    690                 695                 700                 


Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys 
705                 710                 715                 720 


Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys 
                725                 730                 735     


Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly 
            740                 745                 750         


Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln 
        755                 760                 765             


Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val 
    770                 775                 780                 


Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser 
785                 790                 795                 800 


Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala 
                805                 810                 815     


Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg 
            820                 825                 830         


His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys 
        835                 840                 845             


Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys 
    850                 855                 860                 


Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr 
865                 870                 875                 880 


Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln 
                885                 890                 895     


Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala 
            900                 905                 910         


Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg 
        915                 920                 925             


Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu 
    930                 935                 940                 


Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met 
945                 950                 955                 960 


Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp 
                965                 970                 975     


Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln 
            980                 985                 990         


Lys Glu Glu Glu Ser Gln Gln Gln  Ala Val Leu Glu Gln  Glu Arg Arg 
        995                 1000                 1005             


Asp Arg  Glu Leu Ala Leu Arg  Ile Ala Gln Ser Glu  Ala Glu Leu 
    1010                 1015                 1020             


Ile Ser  Asp Glu Ala Gln Ala  Asp Leu Ala Leu Arg  Arg Asn Asp 
    1025                 1030                 1035             


Gly Thr  Arg Pro Lys Met Thr  Pro Glu Gln Met Ala  Lys Glu Met 
    1040                 1045                 1050             


Ser Glu  Phe Leu Ser Arg Gly  Pro Ala Val Leu Ala  Thr Lys Ala 
    1055                 1060                 1065             


Ala Ala  Gly Thr Lys Lys Tyr  Asp Leu Ser Lys Trp  Lys Tyr Ala 
    1070                 1075                 1080             


Glu Leu  Arg Asp Thr Ile Asn  Thr Ser Cys Asp Ile  Glu Leu Leu 
    1085                 1090                 1095             


Ala Ala  Cys Arg Glu Glu Phe  His Arg Arg Leu Lys  Val Tyr His 
    1100                 1105                 1110             


Ala Trp  Lys Ser Lys Asn Lys  Lys Arg Asn Thr Glu  Thr Glu Gln 
    1115                 1120                 1125             


Arg Ala  Pro Lys Ser Val Thr  Asp Tyr Asp Phe Ala  Pro Phe Leu 
    1130                 1135                 1140             


Asn Asn  Ser Pro Gln Gln Asn  Pro Ala Ala Gln Ile  Pro Ala Arg 
    1145                 1150                 1155             


Gln Arg  Glu Ile Glu Met Asn  Arg Gln Gln Arg Phe  Phe Arg Ile 
    1160                 1165                 1170             


Pro Phe  Ile Arg Pro Ala Asp  Gln Tyr Lys Asp Pro  Gln Ser Lys 
    1175                 1180                 1185             


Lys Lys  Gly Trp Trp Tyr Ala  His Phe Asp Gly Pro  Trp Ile Ala 
    1190                 1195                 1200             


Arg Gln  Met Glu Leu His Pro  Asp Lys Pro Pro Ile  Leu Leu Val 
    1205                 1210                 1215             


Ala Gly  Lys Asp Asp Met Glu  Met Cys Glu Leu Asn  Leu Glu Glu 
    1220                 1225                 1230             


Thr Gly  Leu Thr Arg Lys Arg  Gly Ala Glu Ile Leu  Pro Arg Gln 
    1235                 1240                 1245             


Phe Glu  Glu Ile Trp Glu Arg  Cys Gly Gly Ile Gln  Tyr Leu Gln 
    1250                 1255                 1260             


Asn Ala  Ile Glu Ser Arg Gln  Ala Arg Pro Thr Tyr  Ala Thr Ala 
    1265                 1270                 1275             


Met Leu  Gln Ser Leu Leu Lys  
    1280                 1285 


<210>  757
<211>  2028
<212>  DNA
<213>  Homo sapiens

<400>  757
atgaatgata tttcccaaaa ggctgagatt ctgctttctt catctaaacc tgtcccaaaa       60

acctatgtac caaaacttgg caagggtgat gtaaaggata agtttgaagc catgcagaga      120

gccagggaag aaagaaatca aaggagatct agagacgaaa aacaaagaag aaaagaacaa      180

tatattagag agagagaatg gaacaggaga aagcaggaga ttaaagaaat gcttgcttct      240

gatgatgagg aagatgtatc ttctaaagta gaaaaggctt atgttccaaa attaacagga      300

actgtgaagg gtagatttgc tgaaatggag aaacaaagac aagaggaaca aaggaagaga      360

acggaggagg aacgaaaacg cagaattgag caggatatgt tagaaaagag gaaaatacag      420

cgtgaattag caaaaagggc tgaacagatt gaggacataa acaatacggg aactgaatca      480

gcatcagagg aaggagatga ttcactactt ataactgtgg tacctgtcaa atcatataaa      540

acatctggaa aaatgaaaaa gaattttgag gatctagaaa aagaacgtga agagaaagaa      600

aggatcaagt acgaggaaga taaaagaata agatatgaag aacaacgacc atctctcaag      660

gaagcaaagt gtctttcatt agttatggat gatgaaatag aaagtgaagc aaaaaaagaa      720

tcactttctc ccggaaaatt gaaactaact tttgaagaac tggagcgaca aagacaagaa      780

aaccgaaaga agcaagctga agaggaagca agaaaacgtt tagaagaaga gaagcgtgct      840

tttgaagaag caaggcggca aatggtaaat gaagatgagg aaaaccaaga cacagcaaaa      900

atttttaaag ggtaccgccc tggtaaactc aaactcagtt ttgaagaaat ggaaaggcaa      960

agaagagaag atgaaaaaag gaaagcagaa gaagaagcca gaaggagaat agaggaagaa     1020

aagaaggcgt ttgctgaagc aaggagaaat atggtagtag atgatgactc cccagagatg     1080

tataagacaa tctctcaaga atttcttaca ccgggaaaac tggaaattaa ttttgaagaa     1140

ttattaaaac aaaaaatgga agaagaaaaa cgacgaacag aggaggaacg gaagcataag     1200

ctagaaatgg agaaacaaga atttgaacaa ctgagacagg aaatgggaga ggaagaggaa     1260

gaaaatgaaa cctttggatt gagcagagaa tatgaagaac tgatcaaatt aaaaaggagt     1320

ggctctattc aagctaaaaa cctaaaaagc aagtttgaaa aaattggaca gttgtctgaa     1380

aaagaaatac agaaaaaaat agaagaagag cgagcaagaa ggagagcaat tgaccttgaa     1440

attaaagagc gagaagctga aaattttcat gaggaagatg atgttgatgt taggcctgca     1500

agaaaaagcg aggctccatt tactcacaaa gtgaatatga aagctagatt tgaacaaatg     1560

gctaaggcaa gagaagaaga agaacaaaga agaattgaag aacaaaagtt actacgcatg     1620

cagtttgaac aaagggaaat tgatgcagca ctacaaaaga aaagagaaga ggaggaggag     1680

gaagaaggta gcatcatgaa tggctccact gctgaagatg aagagcaaac cagatcagga     1740

gctccatggt tcaagaagcc tcttaaaaac acatcagttg tagacagtga gccagtcaga     1800

tttacggtta aagtaacagg agaacccaaa ccagaaatta catggtggtt tgaaggagaa     1860

atactgcagg atggagaaga ctatcaatat attgaaaggg gagaaactta ctgcctttac     1920

ttaccagaaa ctttcccaga agatggagga gagtatatgt gtaaagcagt caacaataaa     1980

ggatctgcag ctagtacctg tattcttacc attgaaagta agaattaa                  2028


<210>  758
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Asn Asp Ile Ser Gln Lys Ala Glu Ile Leu Leu Ser Ser Ser Lys 
1               5                   10                  15      


Pro Val Pro Lys Thr Tyr Val Pro Lys Leu Gly Lys Gly Asp Val Lys 
            20                  25                  30          


Asp Lys Phe Glu Ala Met Gln Arg Ala Arg Glu Glu Arg Asn Gln Arg 
        35                  40                  45              


Arg Ser Arg Asp Glu Lys Gln Arg Arg Lys Glu Gln Tyr Ile Arg Glu 
    50                  55                  60                  


Arg Glu Trp Asn Arg Arg Lys Gln Glu Ile Lys Glu Met Leu Ala Ser 
65                  70                  75                  80  


Asp Asp Glu Glu Asp Val Ser Ser Lys Val Glu Lys Ala Tyr Val Pro 
                85                  90                  95      


Lys Leu Thr Gly Thr Val Lys Gly Arg Phe Ala Glu Met Glu Lys Gln 
            100                 105                 110         


Arg Gln Glu Glu Gln Arg Lys Arg Thr Glu Glu Glu Arg Lys Arg Arg 
        115                 120                 125             


Ile Glu Gln Asp Met Leu Glu Lys Arg Lys Ile Gln Arg Glu Leu Ala 
    130                 135                 140                 


Lys Arg Ala Glu Gln Ile Glu Asp Ile Asn Asn Thr Gly Thr Glu Ser 
145                 150                 155                 160 


Ala Ser Glu Glu Gly Asp Asp Ser Leu Leu Ile Thr Val Val Pro Val 
                165                 170                 175     


Lys Ser Tyr Lys Thr Ser Gly Lys Met Lys Lys Asn Phe Glu Asp Leu 
            180                 185                 190         


Glu Lys Glu Arg Glu Glu Lys Glu Arg Ile Lys Tyr Glu Glu Asp Lys 
        195                 200                 205             


Arg Ile Arg Tyr Glu Glu Gln Arg Pro Ser Leu Lys Glu Ala Lys Cys 
    210                 215                 220                 


Leu Ser Leu Val Met Asp Asp Glu Ile Glu Ser Glu Ala Lys Lys Glu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys Leu Lys Leu Thr Phe Glu Glu Leu Glu Arg 
                245                 250                 255     


Gln Arg Gln Glu Asn Arg Lys Lys Gln Ala Glu Glu Glu Ala Arg Lys 
            260                 265                 270         


Arg Leu Glu Glu Glu Lys Arg Ala Phe Glu Glu Ala Arg Arg Gln Met 
        275                 280                 285             


Val Asn Glu Asp Glu Glu Asn Gln Asp Thr Ala Lys Ile Phe Lys Gly 
    290                 295                 300                 


Tyr Arg Pro Gly Lys Leu Lys Leu Ser Phe Glu Glu Met Glu Arg Gln 
305                 310                 315                 320 


Arg Arg Glu Asp Glu Lys Arg Lys Ala Glu Glu Glu Ala Arg Arg Arg 
                325                 330                 335     


Ile Glu Glu Glu Lys Lys Ala Phe Ala Glu Ala Arg Arg Asn Met Val 
            340                 345                 350         


Val Asp Asp Asp Ser Pro Glu Met Tyr Lys Thr Ile Ser Gln Glu Phe 
        355                 360                 365             


Leu Thr Pro Gly Lys Leu Glu Ile Asn Phe Glu Glu Leu Leu Lys Gln 
    370                 375                 380                 


Lys Met Glu Glu Glu Lys Arg Arg Thr Glu Glu Glu Arg Lys His Lys 
385                 390                 395                 400 


Leu Glu Met Glu Lys Gln Glu Phe Glu Gln Leu Arg Gln Glu Met Gly 
                405                 410                 415     


Glu Glu Glu Glu Glu Asn Glu Thr Phe Gly Leu Ser Arg Glu Tyr Glu 
            420                 425                 430         


Glu Leu Ile Lys Leu Lys Arg Ser Gly Ser Ile Gln Ala Lys Asn Leu 
        435                 440                 445             


Lys Ser Lys Phe Glu Lys Ile Gly Gln Leu Ser Glu Lys Glu Ile Gln 
    450                 455                 460                 


Lys Lys Ile Glu Glu Glu Arg Ala Arg Arg Arg Ala Ile Asp Leu Glu 
465                 470                 475                 480 


Ile Lys Glu Arg Glu Ala Glu Asn Phe His Glu Glu Asp Asp Val Asp 
                485                 490                 495     


Val Arg Pro Ala Arg Lys Ser Glu Ala Pro Phe Thr His Lys Val Asn 
            500                 505                 510         


Met Lys Ala Arg Phe Glu Gln Met Ala Lys Ala Arg Glu Glu Glu Glu 
        515                 520                 525             


Gln Arg Arg Ile Glu Glu Gln Lys Leu Leu Arg Met Gln Phe Glu Gln 
    530                 535                 540                 


Arg Glu Ile Asp Ala Ala Leu Gln Lys Lys Arg Glu Glu Glu Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Ser Ile Met Asn Gly Ser Thr Ala Glu Asp Glu Glu Gln 
                565                 570                 575     


Thr Arg Ser Gly Ala Pro Trp Phe Lys Lys Pro Leu Lys Asn Thr Ser 
            580                 585                 590         


Val Val Asp Ser Glu Pro Val Arg Phe Thr Val Lys Val Thr Gly Glu 
        595                 600                 605             


Pro Lys Pro Glu Ile Thr Trp Trp Phe Glu Gly Glu Ile Leu Gln Asp 
    610                 615                 620                 


Gly Glu Asp Tyr Gln Tyr Ile Glu Arg Gly Glu Thr Tyr Cys Leu Tyr 
625                 630                 635                 640 


Leu Pro Glu Thr Phe Pro Glu Asp Gly Gly Glu Tyr Met Cys Lys Ala 
                645                 650                 655     


Val Asn Asn Lys Gly Ser Ala Ala Ser Thr Cys Ile Leu Thr Ile Glu 
            660                 665                 670         


Ser Lys Asn 
        675 


<210>  759
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  759
atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt       60

gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc      120

atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc      180

tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg      240

ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag      300

cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt      360

gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta      420

gattacacga gctgtgctca gaactggatc tatgaatga                             459


<210>  760
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  760

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  761
<211>  3960
<212>  DNA
<213>  Homo sapiens

<400>  761
gcgggggcgg gctttgccga gcgcagagct gcagccgccg agccggacgt gtgcgcgaag       60

atggcgggcc ggagcatgca agcggcaaga tgtcctacag atgaattatc tttaaccaat      120

tgttcagttg tgaatgaaaa ggatttccag tctggccagc atgtgattgt gaggacctct      180

cccaatcaca ggtacacatt tacactgaag acacatccat cggtggttcc agggagcatt      240

gcattcagtt tacctcagag aaaatgggct gggctttcta ttgggcaaga aatagaagtc      300

tccttatata catttgacaa agccaaacag tgtattggca caatgaccat cgagattgat      360

ttcctgcaga aaaaaagcaa tgactccaac ccttatgaca ccgacaagat ggcagcagaa      420

tttattcagc aattcaacaa ccaggcctac tcagtgggac aacagcttgt ctttagcttc      480

aatgaaaagc tttttggctt actggtgaag gacattgaat ccatggatcc tagcatcctg      540

aagggagagc ctgcgacagg gaaaaggcag aagattgaag taggactggt tgttggaaac      600

agtcaagttg catttgaaaa agcagaaaat tcgtcactta atcttattgg caaagctaaa      660

accaaggaaa atcgccaatc aattatcaat cctgactgga actttgaaaa aatgggaata      720

ggaggtctag acaaggaatt ttcagatatt ttccgacgag catttgcctt ccgagtattt      780

cctccagaga ttgtggagca gatgggttgt atacatgtta aaggcatcct gttatatgga      840

cccccaggtt gtggtaagac tctcttggct cgacagattg gcaagatgtt gaatgcaaga      900

gagcccaaag tggtcaatgg gccagaaatc cttaacaaat atgtgggaga atcagaggct      960

aacattcgca aactttttgc tgatgctgaa gaggagcaaa ggaggcttgg tgctaacagt     1020

ggtttgcaca tcatcatctt tgatgaaatt gatgccatct gcaagcagag agggagcatg     1080

gctggtagca cgggagttca tgacactgtt gtcaaccagt tgctgtccaa aattgatggc     1140

gtggagcagc taaacaacat cctagtcatt ggaatgacca atagaccaga tctgatagat     1200

gaggctcttc ttagacctgg aagactggaa gttaaaatgg agataggctt gccagatgag     1260

aaaggccgac tacagattct tcacatccac acagcaagaa tgagagggca tcagttactc     1320

tctgctgatg tagacattaa agaactggcc gtggagacca agaatttcag tggtgctgaa     1380

ttggagggtc tggtgcgagc agcccagtcc actgctatga atagacacat aaaggccagt     1440

actaaagtgg aagtggacat ggagaaagca gaaagcctgc aagtgacgag aggagacttc     1500

cttgcttctt tggagaatga tatcaaacca gcctttggca caaaccaaga agattatgca     1560

agttacatta tgaacggtat catcaaatgg ggtgacccag ttactcgagt tctagatgat     1620

ggggagctgc tggtgcagca gactaagaac agtgaccgca caccattggt cagcgtgctt     1680

ctggaaggcc ctcctcacag tgggaagact gctttagctg caaaaattgc agaggaatcc     1740

aacttcccgt tcatcaagat ctgttctcct gataaaatga ttggcttttc tgaaacagcc     1800

aaatgtcagg ccatgaagaa gatctttgat gatgcgtaca aatcccagct cagttgtgtg     1860

gttgtggatg acattgagag attgcttgat tacgtcccta ttggccctcg attttcaaat     1920

cttgtattac aggctcttct cgttttactg aaaaaggcac ctcctcaggg ccgcaagctt     1980

cttatcattg ggaccactag ccgcaaagat gtccttcagg agatggaaat gcttaacgct     2040

ttcagcacca ccatccacgt gcccaacatt gccacaggag agcagctgtt ggaagctttg     2100

gagcttttgg gcaacttaaa ggataaggaa cgcaccacaa ttgcacagca agtcaaaggg     2160

aagaaggtct ggataggaat caagaagtta ctaatgctga tcgagatgtc cctacagatg     2220

gatcctgaat accgtgtgag aaaattcttg gccctcttaa gagaagaagg agctagcccc     2280

cttgattttg attgaaaatg aactatttga aacacacagt gaccaaggga agtgaccaag     2340

gtgaagatgg cctaggatct tcactgtctt actcaagata ctggactaag tggaacgttc     2400

tctaccttca acatgtgctc gctctgcatg attagtgcaa taaaactccc ttccttatgc     2460

atactgagat agcttagtgt ctcgtggaag gtgtcaattt ggtttagaat gctgcgctta     2520

ccttcccatg caggctaaag tgattccttc ttgctcagtc cctctgggtg ggaaccatcc     2580

agtacttgtg gacactacac gtttcaacct ctctactagc accatcaccc ttgaaaactc     2640

tcagtcagtg tcatgaatgt tgcatgacaa cagttggccg attagaaggc agactttcta     2700

catgcaaatc tggcttagta aatcgaggtg tgggccagag atcctctgac agctgtcctg     2760

agctaacact aaaagtcact gggtatttgg ttaaaggtct cccacaagac tggtattctc     2820

tttgcctgaa gaaacaaggc attgaatctc taaaatgctg ttctcaatca ttgtcagaga     2880

tgttttcaag ttgcagtcag aagatctttc ttaatagaaa gtcagatgac taccgtgttg     2940

gttgtgactt ccccttaagt ataactaatt tgctctgtgg taagagatat gctcattatt     3000

accacttaga agatgttgtt aaaaacatgt gaaagatagg tatggaaaaa gcatacaccc     3060

ccaaacagaa aggagttatt aaagtaattt acaaacctct cagcactaat tagtgtccaa     3120

ctccaagtgg gtcaattcct tagtataata ttaaggctta ctagtatcac tgctttttcc     3180

ttagcttaat gacttactta gaatttatcc tttattttaa atgatctgta ctatctagtg     3240

tctaaaacac tattctccag aaaaatcaat cattttctag ccctctccct cagtccttta     3300

ttgtccattc caatacattg aacacatttc ctttaccctc cacacacttc ttccaaaagg     3360

aagcacccgt tgagtccttt tgagggtgat ttgtcttaca actgactgac ttagcaggaa     3420

tttaattagg tcatatttgg tgatgagact tatggagtgt gcctctctct cccaactgct     3480

gcttaaaatg caaggacaag caattagaag ccatcctaag gtgcttacct cacacgccac     3540

ccatgaggct tgtggccaca gtggcacttg ggtgtggctc ctctgttatt tgtcctcatg     3600

tgagaaagca gatcatctcc aaatcttgcc atttgtatac ttttggtgga gacttggatg     3660

tcatatcttc tttgttttgg gttttcttcc ctagcttatt ttgtggcttt taaagaagtg     3720

gattgtattg tgagatcctg tgattcctgg tggccagtat cctggattcc tctaagatct     3780

tgcctctttc ctcctcatga aagcagcaca cattgtgtta acttatgtct cttgttaaat     3840

gagcttaatg tctttgtgtt ttgtccaaaa ctgtattgaa aaaatattgt ttaatgcaaa     3900

tgaaggaatg caataaagag taaatatact tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960


<210>  762
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Ala Gly Arg Ser Met Gln Ala Ala Arg Cys Pro Thr Asp Glu Leu 
1               5                   10                  15      


Ser Leu Thr Asn Cys Ser Val Val Asn Glu Lys Asp Phe Gln Ser Gly 
            20                  25                  30          


Gln His Val Ile Val Arg Thr Ser Pro Asn His Arg Tyr Thr Phe Thr 
        35                  40                  45              


Leu Lys Thr His Pro Ser Val Val Pro Gly Ser Ile Ala Phe Ser Leu 
    50                  55                  60                  


Pro Gln Arg Lys Trp Ala Gly Leu Ser Ile Gly Gln Glu Ile Glu Val 
65                  70                  75                  80  


Ser Leu Tyr Thr Phe Asp Lys Ala Lys Gln Cys Ile Gly Thr Met Thr 
                85                  90                  95      


Ile Glu Ile Asp Phe Leu Gln Lys Lys Ser Asn Asp Ser Asn Pro Tyr 
            100                 105                 110         


Asp Thr Asp Lys Met Ala Ala Glu Phe Ile Gln Gln Phe Asn Asn Gln 
        115                 120                 125             


Ala Tyr Ser Val Gly Gln Gln Leu Val Phe Ser Phe Asn Glu Lys Leu 
    130                 135                 140                 


Phe Gly Leu Leu Val Lys Asp Ile Glu Ser Met Asp Pro Ser Ile Leu 
145                 150                 155                 160 


Lys Gly Glu Pro Ala Thr Gly Lys Arg Gln Lys Ile Glu Val Gly Leu 
                165                 170                 175     


Val Val Gly Asn Ser Gln Val Ala Phe Glu Lys Ala Glu Asn Ser Ser 
            180                 185                 190         


Leu Asn Leu Ile Gly Lys Ala Lys Thr Lys Glu Asn Arg Gln Ser Ile 
        195                 200                 205             


Ile Asn Pro Asp Trp Asn Phe Glu Lys Met Gly Ile Gly Gly Leu Asp 
    210                 215                 220                 


Lys Glu Phe Ser Asp Ile Phe Arg Arg Ala Phe Ala Phe Arg Val Phe 
225                 230                 235                 240 


Pro Pro Glu Ile Val Glu Gln Met Gly Cys Ile His Val Lys Gly Ile 
                245                 250                 255     


Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Arg Gln 
            260                 265                 270         


Ile Gly Lys Met Leu Asn Ala Arg Glu Pro Lys Val Val Asn Gly Pro 
        275                 280                 285             


Glu Ile Leu Asn Lys Tyr Val Gly Glu Ser Glu Ala Asn Ile Arg Lys 
    290                 295                 300                 


Leu Phe Ala Asp Ala Glu Glu Glu Gln Arg Arg Leu Gly Ala Asn Ser 
305                 310                 315                 320 


Gly Leu His Ile Ile Ile Phe Asp Glu Ile Asp Ala Ile Cys Lys Gln 
                325                 330                 335     


Arg Gly Ser Met Ala Gly Ser Thr Gly Val His Asp Thr Val Val Asn 
            340                 345                 350         


Gln Leu Leu Ser Lys Ile Asp Gly Val Glu Gln Leu Asn Asn Ile Leu 
        355                 360                 365             


Val Ile Gly Met Thr Asn Arg Pro Asp Leu Ile Asp Glu Ala Leu Leu 
    370                 375                 380                 


Arg Pro Gly Arg Leu Glu Val Lys Met Glu Ile Gly Leu Pro Asp Glu 
385                 390                 395                 400 


Lys Gly Arg Leu Gln Ile Leu His Ile His Thr Ala Arg Met Arg Gly 
                405                 410                 415     


His Gln Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu 
            420                 425                 430         


Thr Lys Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala 
        435                 440                 445             


Gln Ser Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu 
    450                 455                 460                 


Val Asp Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe 
465                 470                 475                 480 


Leu Ala Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln 
                485                 490                 495     


Glu Asp Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp 
            500                 505                 510         


Pro Val Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr 
        515                 520                 525             


Lys Asn Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro 
    530                 535                 540                 


Pro His Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser 
545                 550                 555                 560 


Asn Phe Pro Phe Ile Lys Ile Cys Ser Pro Asp Lys Met Ile Gly Phe 
                565                 570                 575     


Ser Glu Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala 
            580                 585                 590         


Tyr Lys Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu 
        595                 600                 605             


Leu Asp Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln 
    610                 615                 620                 


Ala Leu Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu 
625                 630                 635                 640 


Leu Ile Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu 
                645                 650                 655     


Met Leu Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr 
            660                 665                 670         


Gly Glu Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Leu Lys Asp 
        675                 680                 685             


Lys Glu Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp 
    690                 695                 700                 


Ile Gly Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met 
705                 710                 715                 720 


Asp Pro Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu 
                725                 730                 735     


Gly Ala Ser Pro Leu Asp Phe Asp 
            740                 


<210>  763
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  763
atgagcgggt ttaattttgg aggcactggg gcccctacag gcgggttcac gtttggcact       60

gcaaagacgg caacaaccac acctgctaca gggttttctt tctccacctc tggcactgga      120

gggtttaatt ttggggctcc cttccaacca gccacaagta ccccttccac cggcctgttc      180

tcacttgcca cccagactcc ggccacacag acgacaggct tcacttttgg aacagcgact      240

cttgcttcgg ggggaactgg attttctttg gggatcggtg cttcaaagct caacttgagc      300

aacacagctg ccaccccagc catggcaaac cccagcggct ttgggctggg cagcagcaac      360

ctcactaatg ccatatcgag caccgtcacc tccagccagg gcacagcacc caccggcttt      420

gtgtttggcc cctccaccac ctctgtggct ccagctacca catctggagg cttctcattc      480

actggtggaa gcacggccca accctccggt ttcaacattg gctcagcagg gaattcagcc      540

cagcccacgg cacctgccac gttgcccttc actccggcca cgccagcagc caccacagca      600

ggtgccacac agccagctgc tcccacaccc acagccacca tcaccagcac tgggcccagc      660

ctctttgcgt caatagcaac tgctccaacc tcatctgcca ccactggact ctccctctgt      720

acccctgtga ccacagcggg cgcccccact gctgggacac agggcttcag cttaaaggca      780

cctggagcag cttccggcac ctccacaaca acatccaccg ctgccaccgc caccgccacc      840

accaccagca gcagcagcac caccggcttt gccttgaatt taaaaccact ggcgccagcc      900

gggatcccca gcaatacagc agctgccgtg accgctccac ctggccctgg cgcagctgca      960

ggggcggctg ccagctccgc catgacctac gcgcagctgg agagcctgat caacaaatgg     1020

agcctggagc tagaggacca ggagcggcac ttcctccagc aggccaccca ggtcaacgcc     1080

tgggaccgca cgctgatcga gaatggagaa aagatcacca gcctgcaccg cgaggtggag     1140

aaggtgaagc tggaccagaa gaggctggac caggagctcg acttcatcct gtcccagcag     1200

aaggagctgg aagacctgct gagcccactg gaggagttgg tcaaggagca gagcgggacc     1260

atctacctgc agcacgcgga tgaggagcgt gagaaaacct acaagctggc tgagaacatc     1320

gatgcacagc tcaagcgcat ggcccaggat ctcaaggaca tcatcgagca cctgaacacg     1380

tccggggccc ccgccgacac cagtgaccca ctgcagcaga tctgcaagat cctcaatgcg     1440

cacatggact cactgcagtg gatcgaccag aactcggccc tgctgcagag gaaggtggag     1500

gaggtgacca aggtgtgcga gggccggcgc aaggagcagg agcgcagctt ccggatcacc     1560

tttgactga                                                             1569


<210>  764
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Ser Gly Phe Asn Phe Gly Gly Thr Gly Ala Pro Thr Gly Gly Phe 
1               5                   10                  15      


Thr Phe Gly Thr Ala Lys Thr Ala Thr Thr Thr Pro Ala Thr Gly Phe 
            20                  25                  30          


Ser Phe Ser Thr Ser Gly Thr Gly Gly Phe Asn Phe Gly Ala Pro Phe 
        35                  40                  45              


Gln Pro Ala Thr Ser Thr Pro Ser Thr Gly Leu Phe Ser Leu Ala Thr 
    50                  55                  60                  


Gln Thr Pro Ala Thr Gln Thr Thr Gly Phe Thr Phe Gly Thr Ala Thr 
65                  70                  75                  80  


Leu Ala Ser Gly Gly Thr Gly Phe Ser Leu Gly Ile Gly Ala Ser Lys 
                85                  90                  95      


Leu Asn Leu Ser Asn Thr Ala Ala Thr Pro Ala Met Ala Asn Pro Ser 
            100                 105                 110         


Gly Phe Gly Leu Gly Ser Ser Asn Leu Thr Asn Ala Ile Ser Ser Thr 
        115                 120                 125             


Val Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly Pro 
    130                 135                 140                 


Ser Thr Thr Ser Val Ala Pro Ala Thr Thr Ser Gly Gly Phe Ser Phe 
145                 150                 155                 160 


Thr Gly Gly Ser Thr Ala Gln Pro Ser Gly Phe Asn Ile Gly Ser Ala 
                165                 170                 175     


Gly Asn Ser Ala Gln Pro Thr Ala Pro Ala Thr Leu Pro Phe Thr Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Thr Thr Ala Gly Ala Thr Gln Pro Ala Ala Pro 
        195                 200                 205             


Thr Pro Thr Ala Thr Ile Thr Ser Thr Gly Pro Ser Leu Phe Ala Ser 
    210                 215                 220                 


Ile Ala Thr Ala Pro Thr Ser Ser Ala Thr Thr Gly Leu Ser Leu Cys 
225                 230                 235                 240 


Thr Pro Val Thr Thr Ala Gly Ala Pro Thr Ala Gly Thr Gln Gly Phe 
                245                 250                 255     


Ser Leu Lys Ala Pro Gly Ala Ala Ser Gly Thr Ser Thr Thr Thr Ser 
            260                 265                 270         


Thr Ala Ala Thr Ala Thr Ala Thr Thr Thr Ser Ser Ser Ser Thr Thr 
        275                 280                 285             


Gly Phe Ala Leu Asn Leu Lys Pro Leu Ala Pro Ala Gly Ile Pro Ser 
    290                 295                 300                 


Asn Thr Ala Ala Ala Val Thr Ala Pro Pro Gly Pro Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Ala Ala Ala Ser Ser Ala Met Thr Tyr Ala Gln Leu Glu Ser Leu 
                325                 330                 335     


Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln Glu Arg His Phe Leu 
            340                 345                 350         


Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg Thr Leu Ile Glu Asn 
        355                 360                 365             


Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val Glu Lys Val Lys Leu 
    370                 375                 380                 


Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe Ile Leu Ser Gln Gln 
385                 390                 395                 400 


Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu Glu Leu Val Lys Glu 
                405                 410                 415     


Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp Glu Glu Arg Glu Lys 
            420                 425                 430         


Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys Arg Met Ala 
        435                 440                 445             


Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn Thr Ser Gly Ala Pro 
    450                 455                 460                 


Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile Leu Asn Ala 
465                 470                 475                 480 


His Met Asp Ser Leu Gln Trp Ile Asp Gln Asn Ser Ala Leu Leu Gln 
                485                 490                 495     


Arg Lys Val Glu Glu Val Thr Lys Val Cys Glu Gly Arg Arg Lys Glu 
            500                 505                 510         


Gln Glu Arg Ser Phe Arg Ile Thr Phe Asp 
        515                 520         


<210>  765
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  765
atgtcatcca ggcctcttga aagtccacct ccttacaggc ctgatgaatt caaaccgaat       60

cattatgcac caagcaatga catatatggt ggagagatgc atgttcgacc aatgctctct      120

cagccagcct actcttttta cccagaagat gaaattcttc acttctacaa atggacctct      180

cctccaggag tgattcggat cctgtctatg ctcattattg tgatgtgcat tgccatcttt      240

gcctgtgtgg cctccacgct tgcctgggac agaggctatg gaacttccct tttaggaggt      300

agtgtaggct acccttatgg aggaagtggc tttggtagct acggaagtgg ctatggctat      360

ggctatggtt atggctatgg ctacggaggc tatacagacc caagagcagc aaagggcttc      420

atgttggcca tggctgcctt ttgtttcatt gccgcgttgg tgatctttgt taccagtgtt      480

ataagatctg aaatgtccag aacaagaaga tactacttaa gtgtgataat agtgagtgct      540

atcctgggca tcatggtgtt tattgccaca attgtctata taatgggagt gaacccaact      600

gctcagtctt ctggatctct atatggttca caaatatatg ccctctgcaa ccaattttat      660

acacctgcag ctactggact ctacgtggat cagtatttgt atcactactg tgttgtggat      720

ccccaggagg ccattgccat tgtactgggg ttcatgatta ttgtggcttt tgctttaata      780

attttctttg ctgtgaaaac tcgaagaaag atggacaggt atgacaagtc caatattttg      840

tgggacaagg aacacattta tgatgagcag ccccccaatg tcgaggagtg ggttaaaaat      900

gtgtctgcag gcacacagga cgtgccttca cccccatctg actatgtgga aagagttgac      960

agtcccatgg catactcttc caatggcaaa gtgaatgaca agcggtttta tccagagtct     1020

tcctataaat ccacgccggt tcctgaagtg gttcaggagc ttccattaac ttcgcctgtg     1080

gatgacttca ggcagcctcg ttacagcagc ggtggtaact ttgagacacc ttcaaaaaga     1140

gcacctgcaa agggaagagc aggaaggtca aagagaacag agcaagatca ctatgagaca     1200

gactacacaa ctggcggcga gtcctgtgat gagctggagg aggactggat cagggaatat     1260

ccacctatca cttcagatca acaaagacaa ctgtacaaga ggaattttga cactggccta     1320

caggaataca agagcttaca atcagaactt gatgagatca ataaagaact ctcccgtttg     1380

gataaagaat tggatgacta tagagaagaa agtgaagagt acatggctgc tgctgatgaa     1440

tacaatagac tgaagcaagt gaagggatct gcagattaca aaagtaagaa gaatcattgc     1500

aagcagttaa agagcaaatt gtcacacatc aagaagatgg ttggagacta tgatagacag     1560

aaaacatag                                                             1569


<210>  766
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  766

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  767
<211>  1734
<212>  DNA
<213>  Homo sapiens

<400>  767
atgtcccatc aacctctcag ctgcctcact gaaaaggagg acagccccag tgaaagcaca       60

ggaaatggac ccccccacct ggcccaccca aacctggaca cgtttacccc ggaggagctg      120

ctgcagcaga tgaaagagct cctgaccgag aaccaccagc tgaaagaagc catgaagcta      180

aataatcaag ccatgaaagg gagatttgag gagctttcgg cctggacaga gaaacagaag      240

gaagaacgcc agttttttga gatacagagc aaagaagcaa aagagcgtct aatggccttg      300

agtcatgaga atgagaaatt gaaggaagag cttggaaaac taaaagggaa atcagaaagg      360

tcatctgagg accccactga tgactccagg cttcccaggg ccgaagcgga gcaggaaaag      420

gaccagctca ggacccaggt ggtgaggcta caagcagaga aggcagacct gttgggcatc      480

gtgtctgaac tgcagctcaa gctgaactcc agcggctcct cagaagattc ctttgttgaa      540

attaggatgg ctgaaggaga agcagaaggg tcagtaaaag aaatcaagca tagtcctggg      600

cccacgagaa cagtctccac tggcacggca ttgtctaaat ataggagcag atctgcagat      660

ggggccaaga attacttcga acatgaggag ttaactgtga gccagctcct gctgtgccta      720

agggaaggga atcagaaggt ggagagactt gaagttgcac tcaaggaggc caaagaaaga      780

gtttcagatt ttgaaaagaa aacaagtaat cgttctgaga ttgaaaccca gacagagggg      840

agcacagaga aagagaatga tgaagagaaa ggcccggaga ctgttggaag cgaagtggaa      900

gcactgaacc tccaggtgac atctctgttt aaggagcttc aagaggctca tacaaaactc      960

agcaaagctg agctaatgaa gaagagactt caagaaaagt gtcaggccct tgaaaggaaa     1020

aattctgcaa ttccatcaga gttgaatgaa aagcaagagc ttgtttatac taacaaaaag     1080

ttagagctac aagtggaaag catgctatca gaaatcaaaa tggaacaggc taaaacagag     1140

gatgaaaagt ccaaattaac tgtgctacag atgacacaca acaagcttct tcaagaacat     1200

aataatgcat tgaaaacaat tgaggaacta acaagaaaag agtcagaaaa agtggacagg     1260

gcagtgctga aggaactgag tgaaaaactg gaactggcag agaaggctct ggcttccaaa     1320

cagctgcaaa tggatgaaat gaagcaaacc attgccaagc aggaagagga cctggaaacc     1380

atgaccatcc tcagggctca gatggaagtt tactgttctg attttcatgc tgaaagagca     1440

gcgagagaga aaattcatga ggaaaaggag caactggcat tgcagctggc agttctgctg     1500

aaagagaatg atgctttcga agacggaggc aggcagtcct tgatggagat gcagagtcgt     1560

catggggcga gaacaagtga ctctgaccag caggcttacc ttgttcaaag aggagctgag     1620

gacagggact ggcggcaaca gcggaatatt ccgattcatt cctgccccaa gtgtggagag     1680

gttctgcctg acatagacac gttacagatt cacgtgatgg attgcatcat ttaa           1734


<210>  768
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Ser His Gln Pro Leu Ser Cys Leu Thr Glu Lys Glu Asp Ser Pro 
1               5                   10                  15      


Ser Glu Ser Thr Gly Asn Gly Pro Pro His Leu Ala His Pro Asn Leu 
            20                  25                  30          


Asp Thr Phe Thr Pro Glu Glu Leu Leu Gln Gln Met Lys Glu Leu Leu 
        35                  40                  45              


Thr Glu Asn His Gln Leu Lys Glu Ala Met Lys Leu Asn Asn Gln Ala 
    50                  55                  60                  


Met Lys Gly Arg Phe Glu Glu Leu Ser Ala Trp Thr Glu Lys Gln Lys 
65                  70                  75                  80  


Glu Glu Arg Gln Phe Phe Glu Ile Gln Ser Lys Glu Ala Lys Glu Arg 
                85                  90                  95      


Leu Met Ala Leu Ser His Glu Asn Glu Lys Leu Lys Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Lys Gly Lys Ser Glu Arg Ser Ser Glu Asp Pro Thr Asp Asp 
        115                 120                 125             


Ser Arg Leu Pro Arg Ala Glu Ala Glu Gln Glu Lys Asp Gln Leu Arg 
    130                 135                 140                 


Thr Gln Val Val Arg Leu Gln Ala Glu Lys Ala Asp Leu Leu Gly Ile 
145                 150                 155                 160 


Val Ser Glu Leu Gln Leu Lys Leu Asn Ser Ser Gly Ser Ser Glu Asp 
                165                 170                 175     


Ser Phe Val Glu Ile Arg Met Ala Glu Gly Glu Ala Glu Gly Ser Val 
            180                 185                 190         


Lys Glu Ile Lys His Ser Pro Gly Pro Thr Arg Thr Val Ser Thr Gly 
        195                 200                 205             


Thr Ala Leu Ser Lys Tyr Arg Ser Arg Ser Ala Asp Gly Ala Lys Asn 
    210                 215                 220                 


Tyr Phe Glu His Glu Glu Leu Thr Val Ser Gln Leu Leu Leu Cys Leu 
225                 230                 235                 240 


Arg Glu Gly Asn Gln Lys Val Glu Arg Leu Glu Val Ala Leu Lys Glu 
                245                 250                 255     


Ala Lys Glu Arg Val Ser Asp Phe Glu Lys Lys Thr Ser Asn Arg Ser 
            260                 265                 270         


Glu Ile Glu Thr Gln Thr Glu Gly Ser Thr Glu Lys Glu Asn Asp Glu 
        275                 280                 285             


Glu Lys Gly Pro Glu Thr Val Gly Ser Glu Val Glu Ala Leu Asn Leu 
    290                 295                 300                 


Gln Val Thr Ser Leu Phe Lys Glu Leu Gln Glu Ala His Thr Lys Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Leu Met Lys Lys Arg Leu Gln Glu Lys Cys Gln Ala 
                325                 330                 335     


Leu Glu Arg Lys Asn Ser Ala Ile Pro Ser Glu Leu Asn Glu Lys Gln 
            340                 345                 350         


Glu Leu Val Tyr Thr Asn Lys Lys Leu Glu Leu Gln Val Glu Ser Met 
        355                 360                 365             


Leu Ser Glu Ile Lys Met Glu Gln Ala Lys Thr Glu Asp Glu Lys Ser 
    370                 375                 380                 


Lys Leu Thr Val Leu Gln Met Thr His Asn Lys Leu Leu Gln Glu His 
385                 390                 395                 400 


Asn Asn Ala Leu Lys Thr Ile Glu Glu Leu Thr Arg Lys Glu Ser Glu 
                405                 410                 415     


Lys Val Asp Arg Ala Val Leu Lys Glu Leu Ser Glu Lys Leu Glu Leu 
            420                 425                 430         


Ala Glu Lys Ala Leu Ala Ser Lys Gln Leu Gln Met Asp Glu Met Lys 
        435                 440                 445             


Gln Thr Ile Ala Lys Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu 
    450                 455                 460                 


Arg Ala Gln Met Glu Val Tyr Cys Ser Asp Phe His Ala Glu Arg Ala 
465                 470                 475                 480 


Ala Arg Glu Lys Ile His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu 
                485                 490                 495     


Ala Val Leu Leu Lys Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln 
            500                 505                 510         


Ser Leu Met Glu Met Gln Ser Arg His Gly Ala Arg Thr Ser Asp Ser 
        515                 520                 525             


Asp Gln Gln Ala Tyr Leu Val Gln Arg Gly Ala Glu Asp Arg Asp Trp 
    530                 535                 540                 


Arg Gln Gln Arg Asn Ile Pro Ile His Ser Cys Pro Lys Cys Gly Glu 
545                 550                 555                 560 


Val Leu Pro Asp Ile Asp Thr Leu Gln Ile His Val Met Asp Cys Ile 
                565                 570                 575     


Ile 
    


<210>  769
<211>  823
<212>  DNA
<213>  Homo sapiens

<400>  769
ctttgaaggg gaggtcacca aggagaacct gctggacttt atcaaacaca accagctgcc       60

ccttgtcatt gagttcaccg agcagagtgt gtctgactat gacggcaaac tgagcaactt      120

caaaacagca gccgagagct tcaagggcaa gatcctgttc atcttcatcg acagcgacca      180

caccgacaac cagcgcatcc tcgagttctt tggcctgaag aaggaagagt gcccggccgt      240

gcgcctcatc accctggagg aggagatgac caagtacaag cccgaatcgg aggagctgac      300

ggcagagtgg atcacagagt tctgccaccg cttcctggag ggcaaaatca agccccacct      360

gatgagccag gagctgccgg aggactggga caagcagcct gtcaaggtgc ttgttgggaa      420

gaactttgaa gacgtggctt ttgatgagaa aaaaaacgtc tttgtggagt tctatgcccc      480

atggtgtggt cactgcaaac agttggctcc catttgggat aaactgggag agacgtacaa      540

ggaccatgag aacatcgtca tcgccaagat ggactcgact gccaacgagg tggaggccgt      600

caaagtgcac agcttcccca cactcaagtt ctttcctgcc agtgccgaca ggacggtcat      660

cgattacaac ggggaacgca cgctggatgg ttttaagaaa ttcctggaga gcggtggcca      720

ggatggggca ggggatgatg acgatctcga ggacctggaa gaagcagagg agccagacat      780

ggaggaagac gatgatcaga aagctgtgaa agatgaactg taa                        823


<210>  770
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  770

Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His 
1               5                   10                  15      


Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Ser Val Ser Asp 
            20                  25                  30          


Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys 
        35                  40                  45              


Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln 
    50                  55                  60                  


Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val 
65                  70                  75                  80  


Arg Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser 
                85                  90                  95      


Glu Glu Leu Thr Ala Glu Trp Ile Thr Glu Phe Cys His Arg Phe Leu 
            100                 105                 110         


Glu Gly Lys Ile Lys Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp 
        115                 120                 125             


Trp Asp Lys Gln Pro Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp 
    130                 135                 140                 


Val Ala Phe Asp Glu Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro 
145                 150                 155                 160 


Trp Cys Gly His Cys Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly 
                165                 170                 175     


Glu Thr Tyr Lys Asp His Glu Asn Ile Val Ile Ala Lys Met Asp Ser 
            180                 185                 190         


Thr Ala Asn Glu Val Glu Ala Val Lys Val His Ser Phe Pro Thr Leu 
        195                 200                 205             


Lys Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly 
    210                 215                 220                 


Glu Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln 
225                 230                 235                 240 


Asp Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu 
                245                 250                 255     


Glu Pro Asp Met Glu Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu 
            260                 265                 270         


Leu 
    


<210>  771
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  771
atgtctgacg gtctggataa tgaagagaaa cccccggctc ctccactgag gatgaatagt       60

aacaaccggg attcttcagc actcaaccac agctccaaac cacttcccat ggcccctgaa      120

gagaagaata agaaagccag gcttcgctct atcttcccag gaggagggga taaaaccaat      180

aagaagaagg agaaagagcg cccagagatc tctcttcctt cagactttga gcatacgatt      240

catgtggggt ttgatgcagt caccggggaa ttcactccag atctctatgg ctcacagatg      300

tgcccaggga agctcccaga gggaattcca gagcaatggg cacgattact ccaaacttcc      360

aacataacaa aattggaaca gaagaagaac ccacaagctg ttctagatgt tctcaaattc      420

tatgattcca aagaaacagt caacaaccag aaatacatga gctttacatc aggagataaa      480

agtgcacatg gatacatagc agcccatcct tcgagtacaa aaacagcatc tgagcctcca      540

ttggcccctc ctgtgtctga agaagaagat gaagaggaag aagaagaaga agatgaaaat      600

gagccaccac cagttatcgc accaagacca gagcatacaa aatcaatcta tactcgttct      660

gtggttgaat ccattgcttc accagcagta ccaaataaag aggtcacacc accctctgct      720

gaaaatgcca attccagtac tttgtacagg aacacagatc ggcaaagaaa aaaatccaag      780

atgacagatg aggagatctt agagaagcta agaagcattg tgagtgttgg ggacccaaag      840

aaaaaataca caagatttga aaaaattggt caaggggcat caggtactgt ttatacagca      900

ctagacattg caacaggaca agaggtggcc ataaagcaga tgaaccttca acagcaaccc      960

aagaaggaat taattattaa tgaaattctg gtcatgaggg aaaataagaa ccctaatatt     1020

gttaattatt tagatagcta cttggtgggt gatgaactat gggtagtcat ggaatacttg     1080

gctggtggct ctctgactga tgtggtcaca gagacctgta tggatgaagg acagatagca     1140

gctgtctgca gagagtgcct gcaagctttg gatttcctgc actcaaacca ggtgatccat     1200

agagatataa agagtgacaa tattcttctc gggatggatg gctctgttaa attgactgac     1260

tttgggttct gtgcccagat cactcctgag caaagtaaac gaagcactat ggtgggaacc     1320

ccatattgga tggcacctga ggtggtgact cgaaaagctt atggtccgaa agttgatatc     1380

tggtctcttg gaattatggc aattgaaatg gtggaaggtg aaccccctta ccttaatgaa     1440

aatccactca gggcattgta tctgatagcc actaatggaa ctccagagct ccagaatcct     1500

gagagactgt cagctgtatt ccgtgacttt ttaaatcgct gtcttgagat ggatgtggat     1560

aggcgaggat ctgccaagga gcttttgcag catccatttt taaaattagc caagcctctc     1620

tccagcctga ctcctctgat tatcgctgca aaggaagcaa ttaagaacag cagccgctaa     1680


<210>  772
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  772

Met Ser Asp Gly Leu Asp Asn Glu Glu Lys Pro Pro Ala Pro Pro Leu 
1               5                   10                  15      


Arg Met Asn Ser Asn Asn Arg Asp Ser Ser Ala Leu Asn His Ser Ser 
            20                  25                  30          


Lys Pro Leu Pro Met Ala Pro Glu Glu Lys Asn Lys Lys Ala Arg Leu 
        35                  40                  45              


Arg Ser Ile Phe Pro Gly Gly Gly Asp Lys Thr Asn Lys Lys Lys Glu 
    50                  55                  60                  


Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp Phe Glu His Thr Ile 
65                  70                  75                  80  


His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Pro Asp Leu Tyr 
                85                  90                  95      


Gly Ser Gln Met Cys Pro Gly Lys Leu Pro Glu Gly Ile Pro Glu Gln 
            100                 105                 110         


Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln Lys 
        115                 120                 125             


Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser Lys 
    130                 135                 140                 


Glu Thr Val Asn Asn Gln Lys Tyr Met Ser Phe Thr Ser Gly Asp Lys 
145                 150                 155                 160 


Ser Ala His Gly Tyr Ile Ala Ala His Pro Ser Ser Thr Lys Thr Ala 
                165                 170                 175     


Ser Glu Pro Pro Leu Ala Pro Pro Val Ser Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Glu Asn Glu Pro Pro Pro Val Ile Ala Pro 
        195                 200                 205             


Arg Pro Glu His Thr Lys Ser Ile Tyr Thr Arg Ser Val Val Glu Ser 
    210                 215                 220                 


Ile Ala Ser Pro Ala Val Pro Asn Lys Glu Val Thr Pro Pro Ser Ala 
225                 230                 235                 240 


Glu Asn Ala Asn Ser Ser Thr Leu Tyr Arg Asn Thr Asp Arg Gln Arg 
                245                 250                 255     


Lys Lys Ser Lys Met Thr Asp Glu Glu Ile Leu Glu Lys Leu Arg Ser 
            260                 265                 270         


Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg Phe Glu Lys 
        275                 280                 285             


Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Leu Asp Ile Ala 
    290                 295                 300                 


Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln Gln Gln Pro 
305                 310                 315                 320 


Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg Glu Asn Lys 
                325                 330                 335     


Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val Gly Asp Glu 
            340                 345                 350         


Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val 
        355                 360                 365             


Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala Val Cys Arg 
    370                 375                 380                 


Glu Cys Leu Gln Ala Leu Asp Phe Leu His Ser Asn Gln Val Ile His 
385                 390                 395                 400 


Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp Gly Ser Val 
                405                 410                 415     


Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser 
            420                 425                 430         


Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val 
        435                 440                 445             


Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly 
    450                 455                 460                 


Ile Met Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu 
465                 470                 475                 480 


Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu 
                485                 490                 495     


Leu Gln Asn Pro Glu Arg Leu Ser Ala Val Phe Arg Asp Phe Leu Asn 
            500                 505                 510         


Arg Cys Leu Glu Met Asp Val Asp Arg Arg Gly Ser Ala Lys Glu Leu 
        515                 520                 525             


Leu Gln His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr 
    530                 535                 540                 


Pro Leu Ile Ile Ala Ala Lys Glu Ala Ile Lys Asn Ser Ser Arg 
545                 550                 555                 


<210>  773
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  773
atggggcgcg tcgtcgcgga gctcgtctcc tcgctgctgg ggttgtggct gttgctgtgc       60

agctgcggat gccccgaggg cgccgagctg cgtgctccgc cagataaaat cgcgattatt      120

ggagccggaa ttggtggcac ttcagcagcc tattacctgc ggcagaaatt tgggaaagat      180

gtgaagatag acctgtttga aagagaagag gtcgggggcc gcctggctac catgatggtg      240

caggggcaag aatacgaggc aggaggttct gtcatccatc ctttaaatct gcacatgaaa      300

cgttttgtca aagacctggg tctctctgct gttcaggcct ctggtggcct actggggata      360

tataatggag agactctggt atttgaggag agcaactggt tcataattaa cgtgattaaa      420

ttagtttggc gctatggatt tcaatccctc cgtatgcaca tgtgggtaga ggacgtgtta      480

gacaagttca tgaggatcta ccgctaccag tctcatgact atgccttcag tagtgtcgaa      540

aaattacttc atgctctagg aggagatgac ttccttggaa tgcttaatcg aacacttctt      600

gaaaccttgc aaaaggccgg cttttctgag aagttcctca atgaaatgat tgctcctgtt      660

atgagggtca attatggcca aagcacggac atcaatgcct ttgtgggggc ggtgtcactg      720

tcctgttctg attctggcct ttgggcagta gaaggtggca ataaacttgt ttgctcaggg      780

cttctgcagg catccaaaag caatcttata tctggctcag taatgtacat cgaggagaaa      840

acaaagacca agtacacagg aaatccaaca aagatgtatg aagtggtcta ccaaattgga      900

actgagactc gttcagactt ctatgacatc gtcttggtgg ccactccgtt gaatcgaaaa      960

atgtcgaata ttacttttct caactttgat cctccaattg aggaattcca tcaatattat     1020

caacatatag tgacaacttt agttaagggg gaattgaata catctatctt tagctctaga     1080

cccatagata aatttggcct taatacagtt ttaaccactg ataattcaga tttgttcatt     1140

aacagtattg ggattgtgcc ctctgtgaga gaaaaggaag atcctgagcc atcaacagat     1200

ggaacatatg tttggaagat cttttcccaa gaaactctta ctaaagcaca aattttaaag     1260

ctctttctgt cctatgatta tgctgtgaag aagccatggc ttgcatatcc tcactataag     1320

cccccggaga aatgcccctc tatcattctc catgatcgac tttattacct caatggcata     1380

gagtgtgcag caagtgccat ggagatgagt gccattgcag cccacaacgc tgcactcctt     1440

gcctatcacc gctggaacgg gcacacagac atgattgatc aggatggctt atatgagaaa     1500

cttaaaactg aactatga                                                   1518


<210>  774
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp 
1               5                   10                  15      


Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala 
            20                  25                  30          


Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser 
        35                  40                  45              


Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp 
    50                  55                  60                  


Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val 
65                  70                  75                  80  


Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn 
                85                  90                  95      


Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln 
            100                 105                 110         


Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe 
        115                 120                 125             


Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg 
    130                 135                 140                 


Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu 
145                 150                 155                 160 


Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe 
                165                 170                 175     


Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu 
            180                 185                 190         


Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe 
        195                 200                 205             


Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn 
    210                 215                 220                 


Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu 
225                 230                 235                 240 


Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu 
                245                 250                 255     


Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly 
            260                 265                 270         


Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn 
        275                 280                 285             


Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg 
    290                 295                 300                 


Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys 
305                 310                 315                 320 


Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe 
                325                 330                 335     


His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu Leu 
            340                 345                 350         


Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn 
        355                 360                 365             


Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly 
    370                 375                 380                 


Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp 
385                 390                 395                 400 


Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala 
                405                 410                 415     


Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro 
            420                 425                 430         


Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile 
        435                 440                 445             


Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala 
    450                 455                 460                 


Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu 
465                 470                 475                 480 


Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly 
                485                 490                 495     


Leu Tyr Glu Lys Leu Lys Thr Glu Leu 
            500                 505 


<210>  775
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  775
atgagtgctg aggggtacca gtacagagcg ctgtatgatt ataaaaagga aagagaagaa       60

gatattgact tgcacttggg tgacatattg actgtgaata aagggtcctt agtagctctt      120

ggattcagtg atggacagga agccaggcct gaagaaattg gctggttaaa tggctataat      180

gaaaccacag gggaaagggg ggactttccg ggaacttacg tagaatatat tggaaggaaa      240

aaaatctcgc ctcccacacc aaagccccgg ccacctcggc ctcttcctgt tgcaccaggt      300

tcttcgaaaa ctgaagcaga tgttgaacaa caagctttga ctctcccgga tcttgcagag      360

cagtttgccc ctcctgacat tgccccgcct cttcttatca agctcgtgga agccattgaa      420

aagaaaggtc tggaatgttc aactctatac agaacacaga gctccagcaa cctggcagaa      480

ttacgacagc ttcttgattg tgatacaccc tccgtggact tggaaatgat cgatgtgcac      540

gttttggctg acgctttcaa acgctatctc ctggacttac caaatcctgt cattccagca      600

gccgtttaca gtgaaatgat ttctttagct ccagaagtac aaagctccga agaatatatt      660

cagctattga agaagcttat taggtcgcct agcatacctc atcagtattg gcttacgctt      720

cagtatttgt taaaacattt cttcaagctc tctcaaacct ccagcaaaaa tctgttgaat      780

gcaagagtac tctctgaaat tttcagccct atgcttttca gattctcagc agccagctct      840

gataatactg aaaacctcat aaaagttata gaaattttaa tctcaactga atggaatgaa      900

cgacagcctg caccagcact gcctcctaaa ccaccaaaac ctactactgt agccaacaac      960

ggtatgaata acaatatgtc cttacaagat gctgaatggt actggggaga tatctcgagg     1020

gaagaagtga atgaaaaact tcgagataca gcagacggga cctttttggt acgagatgcg     1080

tctactaaaa tgcatggtga ttatactctt acactaagga aagggggaaa taacaaatta     1140

atcaaaatat ttcatcgaga tgggaaatat ggcttctctg acccattaac cttcagttct     1200

gtggttgaat taataaacca ctaccggaat gaatctctag ctcagtataa tcccaaattg     1260

gatgtgaaat tactttatcc agtatccaaa taccaacagg atcaagttgt caaagaagat     1320

aatattgaag ctgtagggaa aaaattacat gaatataaca ctcagtttca agaaaaaagt     1380

cgagaatatg atagattata tgaagaatat acccgcacat cccaggaaat ccaaatgaaa     1440

aggacagcta ttgaagcatt taatgaaacc ataaaaatat ttgaagaaca gtgccagacc     1500

caagagcggt acagcaaaga atacatagaa aagtttaaac gtgaaggcaa tgagaaagaa     1560

atacaaagga ttatgcataa ttatgataag ttgaagtctc gaatcagtga aattattgac     1620

agtagaagaa gattggaaga agacttgaag aagcaggcag ctgagtatcg agaaattgac     1680

aaacgtatga acagcattaa accagacctt atccagctga gaaagacgag agaccaatac     1740

ttgatgtggt tgactcaaaa aggtgttcgg caaaagaagt tgaacgagtg gttgggcaat     1800

gaaaacactg aagaccaata ttcactggtg gaagatgatg aagatttgcc ccatcatgat     1860

gagaagacat ggaatgttgg aagcagcaac cgaaacaaag ctgaaaacct gttgcgaggg     1920

aagcgagatg gcacttttct tgtccgggag agcagtaaac agggctgcta tgcctgctct     1980

gtagtggtgg acggcgaagt aaagcattgt gtcataaaca aaacagcaac tggctatggc     2040

tttgccgagc cctataactt gtacagctct ctgaaagaac tggtgctaca ttaccaacac     2100

acctcccttg tgcagcacaa cgactccctc aatgtcacac tagcctaccc agtatatgca     2160

cagcagaggc gatga                                                      2175


<210>  776
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  776

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  777
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  777
atgtccgaca gcgagaagct caacctggac tcgatcatcg ggcgcctgct ggaagtgcag       60

ggctcgcggc ctggcaagaa tgtacagctg acagagaacg agatccgcgg tctgtgcctg      120

aaatcccggg agatttttct gagccagccc attcttctgg agctggaggc acccctcaag      180

atctgcggtg acatacacgg ccagtactac gaccttctgc gactatttga gtatggcggt      240

ttccctcccg agagcaacta cctctttctg ggggactatg tggacagggg caagcagtcc      300

ttggagacca tctgcctgct gctggcctat aagatcaagt accccgagaa cttcttcctg      360

ctccgtggga accacgagtg tgccagcatc aaccgcatct atggtttcta cgatgagtgc      420

aagagacgct acaacatcaa actgtggaaa accttcactg actgcttcaa ctgcctgccc      480

atcgcggcca tagtggacga aaagatcttc tgctgccacg gaggcctgtc cccggacctg      540

cagtctatgg agcagattcg gcggatcatg cggcccacag atgtgcctga ccagggcctg      600

ctgtgtgacc tgctgtggtc tgaccctgac aaggacgtgc agggctgggg cgagaacgac      660

cgtggcgtct cttttacctt tggagccgag gtggtggcca agttcctcca caagcacgac      720

ttggacctca tctgccgagc acaccaggtg gtagaagacg gctacgagtt ctttgccaag      780

cggcagctgg tgacactttt ctcagctccc aactactgtg gcgagtttga caatgctggc      840

gccatgatga gtgtggacga gaccctcatg tgctctttcc agatcctcaa gcccgccgac      900

aagaacaagg ggaagtacgg gcagttcagt ggcctgaacc ctggaggccg acccatcacc      960

ccaccccgca attccgccaa agccaagaaa tag                                   993


<210>  778
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  778

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  779
<211>  3093
<212>  DNA
<213>  Homo sapiens

<400>  779
atgaagatgg cggacgcgaa gcagaagcgg aacgagcagc tgaaacgctg gatcggctcc       60

gagacggacc tcgagcctcc ggtggtgaag cgccagaaga ccaaggtgaa gttcgacgat      120

ggcgccgtct tcctggctgc ttgctccagc ggcgacacgg acgaggtcct caagctgctg      180

caccgcggcg ccgacatcaa ttacgccaat gtggacggac tcactgccct gcaccaggct      240

tgcattgatg acaatgttga tatggtgaag tttctggtag aaaatggagc aaatattaat      300

caacctgata atgaaggctg gataccacta catgcagcag cttcctgtgg atatcttgat      360

attgcagagt ttttgattgg tcaaggagca catgtagggg ctgtcaacag tgaaggagat      420

acacctttag atattgcgga ggaggaggca atggaagagc tacttcaaaa tgaagttaat      480

cggcaagggg ttgatataga agcagctcga aaggaagaag aacggatcat gcttagagat      540

gccaggcagt ggctaaatag tggtcatata aatgatgtcc ggcatgcaaa atctggaggt      600

acagcacttc acgttgcagc tgctaaaggc tatacggaag ttttaaaact tttaatacag      660

gcaggctatg atgttaatat taaagactat gatggctgga cacctcttca tgctgcagct      720

cattggggta aagaagaagc atgtcgaatt ttagtggaca atctgtgtga tatggagatg      780

gtcaacaaag tgggccaaac agcctttgat gtagcagatg aagacatttt aggatattta      840

gaagagttgc aaaagaaaca aaatctgctc catagtgaaa aacgggacaa gaaatctcca      900

ctaattgaat caacagcaaa tatggacaat aatcagtcac agaagacctt taaaaacaaa      960

gagacgttga ttattgaacc agagaaaaat gcatcccgta ttgaatctct ggaacaagaa     1020

aaggttgatg aagaagaaga aggaaagaag gatgagtcta gctgctctag tgaagaagat     1080

gaggaagatg actcggaatc agaagctgaa acagataaga caaaacccct ggcttctgta     1140

actaatgcca acacttctag tacacaagca gctcctgtag ctgttacaac acctactgtg     1200

tcatcaggtc aagcaacacc tacatcacct attaaaaagt ttccaaccac agctacaaaa     1260

atttctccca aagaagaaga gagaaaagat gagtctcctg caacttggag gttaggactt     1320

agaaagacgg gcagctatgg tgcacttgct gaaatcacag catctaaaga gggtcagaaa     1380

gaaaaagata ctgcaggtgt tacacgttca gcttcaagtc ccagactttc ctcctctttg     1440

gataataaag aaaaggagaa agatagtaaa ggaactaggc ttgcatatgt tgcacctaca     1500

ataccaagac gactagccag tacatctgac attgaagaga aagaaaacag agattcttca     1560

agtttgcgaa caagtagttc atatacaagg agaaaatggg aagatgatct taaaaaaaat     1620

agctcagtta atgaaggatc aacgtatcat aaaagttgct cctttggtag aagacaagat     1680

gatttgatta gttctagtgt tccaagcacc acatcaacac caacagttac ctctgcagct     1740

gggcttcaga aaagcctgct ttccagcaca agcactacta caaagattac aacgggttct     1800

tcctcagcag gcacacaaag cagtacctca aatcgtttgt gggctgagga tagtactgag     1860

aaagaaaagg acagtgttcc tacggcagtg accattcctg ttgctccaac tgttgtaaat     1920

gctgcagctt ctaccacaac cctgactaca actactgctg gcactgtctc ctccacaaca     1980

gaggtcaggg agagacgcag atcatacctc actcctgtta gggatgaaga gtctgaatcc     2040

caaagaaaag caagatctag acaagcaaga caatctagaa gatcaacaca gggagtgaca     2100

ttaactgatc ttcaagaagc tgagaaaaca ataggaagaa gtcgttctac ccgaaccaga     2160

gaacaagaaa atgaagaaaa agaaaaagag gaaaaagaga aacaagataa agagaaacaa     2220

gaagaaaaga aggagtcaga aacatctaga gaagatgaat ataaacaaaa gtactccaga     2280

acgtatgatg agacttacca gcgttatagg ccagtatcaa cttcaagttc aaccactcca     2340

tcctcttcac tttctactat gagcagttca ctgtatgctt caagtcaact aaacaggcca     2400

aatagtcttg taggcataac ttctgcttac tccagaggaa taacaaaaga aaatgaaaga     2460

gagggagaaa aaagagaaga ggagaaagaa ggagaagata aatcacaacc taaatcaatc     2520

agagaacgac gacgaccaag agagaaaaga agatctacag gagtttcatt ttggacacaa     2580

gatagtgatg aaaatgaaca agaacaacaa tcagacacag aagagggatc caataagaaa     2640

gaaactcaga cggattccat ttctagatat gaaaccagtt ctacatcagc tggtgatcga     2700

tatgattcct tgctgggtcg ctctggatca tacagttact tagaagaaag aaaaccttac     2760

agcagcaggc tagaaaagga tgactcaact gactttaaaa agctttatga acaaattcta     2820

gctgaaaatg aaaagctgaa ggcacagcta catgatacaa atatggaact aacagatctt     2880

aaattacagt tggaaaaggc cacccagaga caagaaagat ttgctgatag atcactgttg     2940

gaaatggaaa aaagggaacg aagagctcta gaaagaagaa tatctgaaat ggaagaagag     3000

ctcaaaatgt taccagacct aaaagcagac aaccagaggc taaaggatga aaatggggcc     3060

ttgatcagag ttataagcaa actttccaaa taa                                  3093


<210>  780
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                325                 330                 335     


Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
    370                 375                 380                 


Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                405                 410                 415     


Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
            420                 425                 430         


Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
        435                 440                 445             


Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
    450                 455                 460                 


Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
465                 470                 475                 480 


Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                485                 490                 495     


Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
            500                 505                 510         


Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
        515                 520                 525             


Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
    530                 535                 540                 


Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
545                 550                 555                 560 


Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                565                 570                 575     


Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
            580                 585                 590         


Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
        595                 600                 605             


Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
    610                 615                 620                 


Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
625                 630                 635                 640 


Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                645                 650                 655     


Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
            660                 665                 670         


Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
        675                 680                 685             


Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
    690                 695                 700                 


Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
705                 710                 715                 720 


Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                725                 730                 735     


Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
            740                 745                 750         


Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
        755                 760                 765             


Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
    770                 775                 780                 


Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
785                 790                 795                 800 


Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                805                 810                 815     


Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
            820                 825                 830         


Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
        835                 840                 845             


Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
    850                 855                 860                 


Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
865                 870                 875                 880 


Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                885                 890                 895     


Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
            900                 905                 910         


Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
        915                 920                 925             


Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
    930                 935                 940                 


Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                965                 970                 975     


Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
            980                 985                 990         


Arg Ile Ser Glu Met Glu Glu Glu  Leu Lys Met Leu Pro  Asp Leu Lys 
        995                 1000                 1005             


Ala Asp  Asn Gln Arg Leu Lys  Asp Glu Asn Gly Ala  Leu Ile Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Leu Ser Lys  
    1025                 1030 


<210>  781
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  781
atggagtctg gcagtaccgc cgccagtgag gaggcacgca gccttcgaga atgtgagctc       60

tacgtccaga agcataacat tcaagcgctg ctcaaagatt ctattgtgca gttgtgcact      120

gctcgacctg agagacccat ggcattcctc agggaatact ttgagaggtt ggagaaggag      180

gaggcaaaac agattcagaa tctgcagaaa gcaggcactc gtacagactc aagggaggat      240

gagatttctc ctcctccacc caacccagtg gttaaaggta ggaggcgacg aggtgctatc      300

agcgctgagg tctacacgga ggaagatgcg gcatcctatg ttagaaaggt tataccaaaa      360

gattacaaga caatggccgc tttagccaaa gccattgaaa agaatgtgct gttttcacat      420

cttgatgata atgagagaag tgatattttt gatgccatgt tttcggtctc ctttatcgca      480

ggagagactg tgattcagca aggtgatgaa ggggataact tctatgtgat tgatcaagga      540

gagacggatg tctatgttaa caatgaatgg gcaaccagtg ttggggaagg agggagcttt      600

ggagaacttg ctttgattta tggaacaccg agagcagcca ctgtcaaagc aaagacaaat      660

gtgaaattgt ggggcatcga ccgagacagc tatagaagaa tcctcatggg aagcacactg      720

agaaagcgga agatgtatga ggaattcctt agtaaagtct ctattttaga gtctctggac      780

aagtgggaac gtcttacggt agctgatgca ttggaaccag tgcagtttga agatgggcag      840

aagattgtgg tgcagggaga accaggggat gagttcttca ttattttaga ggggtcagct      900

gctgtgctac aacgtcggtc agaaaatgaa gagtttgttg aagtgggaag attggggcct      960

tctgattatt ttggtgaaat tgcactactg atgaatcgtc ctcgtgctgc cacagttgtt     1020

gctcgtggcc ccttgaagtg cgttaagctg gaccgaccta gatttgaacg tgttcttggc     1080

ccatgctcag acatcctcaa acgaaacatc cagcagtaca acagttttgt gtcactgtct     1140

gtctga                                                                1146


<210>  782
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  783
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  783
atgagcatcg agatcccggc gggactgacg gagctgctgc agggcttcac ggtggaggtg       60

ctgaggcacc agcccgcgga cctgctggag ttcgcgctgc agcacttcac ccgcctgcag      120

caggagaacg agcgcaaagg caccgcgcgc ttcggccatg agggcaggac ctggggggac      180

ctgggcgccg ctgccggggg cggcaccccc agcaaggggg tcaacttcgc cgaggagccc      240

atgcagtccg actccgagga cggggaggag gaggaggcgg cgcccgcgga cgcaggggcg      300

ttcaatgctc cagtaataaa ccgattcaca aggcgtgcct cagtatgtgc agaagcttat      360

aatcctgatg aagaagaaga tgatgcagag tccaggatta tacatccaaa aactgatgat      420

caaagaaata ggttgcaaga ggcttgcaaa gacatcctgc tgtttaagaa tctggatccg      480

gagcagatgt ctcaagtatt agatgccatg tttgaaaaat tggtcaaaga tggggagcat      540

gtaattgatc aaggtgacga tggtgacaac ttttatgtaa ttgatagagg cacatttgat      600

atttatgtga aatgtgatgg tgttggaaga tgtgttggta actatgataa tcgtgggagt      660

ttcggcgaac tggccttaat gtacaataca cccagagcag ctacaatcac tgctacctct      720

cctggtgctc tgtggggttt ggacagggta accttcagga gaataattgt gaaaaacaat      780

gccaaaaaga gaaaaatgta tgaaagcttt attgagtcac tgccattcct taaatctttg      840

gagttttctg aacgcctgaa agtagtagat gtgataggca ccaaagtata caacgatgga      900

gaacaaatca ttgctcaggg agattcggct gattcttttt tcattgtaga atctggagaa      960

gtgaaaatta ctatgaaaag aaagggtaaa tcagaagtgg aagagaatgg tgcagtagaa     1020

atcgctcgat gctcgcgggg acagtacttt ggagagcttg ccctggtaac taacaaacct     1080

cgagcagctt ctgcccacgc cattgggact gtcaaatgtt tagcaatgga tgtgcaagca     1140

tttgaaaggc ttctgggacc ttgcatggaa attatgaaaa ggaacatcgc tacctatgaa     1200

gaacagttag ttgccctgtt tggaacgaac atggatattg ttgaacccac tgcatga        1257


<210>  784
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  784

Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe 
1               5                   10                  15      


Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala 
            20                  25                  30          


Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr 
        35                  40                  45              


Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala 
    50                  55                  60                  


Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro 
65                  70                  75                  80  


Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala 
                85                  90                  95      


Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg 
            100                 105                 110         


Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp 
        115                 120                 125             


Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg 
    130                 135                 140                 


Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro 
145                 150                 155                 160 


Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys 
                165                 170                 175     


Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
            180                 185                 190         


Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val 
        195                 200                 205             


Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
    210                 215                 220                 


Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser 
225                 230                 235                 240 


Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
                245                 250                 255     


Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu 
            260                 265                 270         


Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val 
        275                 280                 285             


Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile 
    290                 295                 300                 


Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu 
305                 310                 315                 320 


Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn 
                325                 330                 335     


Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu 
            340                 345                 350         


Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile 
        355                 360                 365             


Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu 
    370                 375                 380                 


Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu 
385                 390                 395                 400 


Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro 
                405                 410                 415     


Thr Ala 
        


<210>  785
<211>  2016
<212>  DNA
<213>  Homo sapiens

<400>  785
atggctgacc cggctgcggg gccgccgccg agcgagggcg aggagagcac cgtgcgcttc       60

gcccgcaaag gcgccctccg gcagaagaac gtgcatgagg tcaagaacca caaattcacc      120

gcccgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat ctggggcttc      180

gggaagcagg gattccagtg ccaagtttgc tgctttgtgg tgcacaagcg gtgccatgaa      240

tttgtcacat tctcctgccc tggcgctgac aagggtccag cctccgatga cccccgcagc      300

aaacacaagt ttaagatcca cacgtactcc agccccacgt tttgtgacca ctgtgggtca      360

ctgctgtatg gactcatcca ccaggggatg aaatgtgaca cctgcatgat gaatgtgcac      420

aagcgctgcg tgatgaatgt tcccagcctg tgtggcacgg accacacgga gcgccgcggc      480

cgcatctaca tccaggccca catcgacagg gacgtcctca ttgtcctcgt aagagatgct      540

aaaaaccttg tacctatgga ccccaatggc ctgtcagatc cctacgtaaa actgaaactg      600

attcccgatc ccaaaagtga gagcaaacag aagaccaaaa ccatcaaatg ctccctcaac      660

cctgagtgga atgagacatt tagatttcag ctgaaagaat cggacaaaga cagaagactg      720

tcagtagaga tttgggattg ggatttgacc agcaggaatg acttcatggg atctttgtcc      780

tttgggattt ctgaacttca gaaagccagt gttgatggct ggtttaagtt actgagccag      840

gaggaaggcg agtacttcaa tgtgcctgtg ccaccagaag gaagtgaggc caatgaagaa      900

ctgcggcaga aatttgagag ggccaagatc agtcagggaa ccaaggtccc ggaagaaaag      960

acgaccaaca ctgtctccaa atttgacaac aatggcaaca gagaccggat gaaactgacc     1020

gattttaact tcctaatggt gctggggaaa ggcagctttg gcaaggtcat gctttcagaa     1080

cgaaaaggca cagatgagct ctatgctgtg aagatcctga agaaggacgt tgtgatccaa     1140

gatgatgacg tggagtgcac tatggtggag aagcgggtgt tggccctgcc tgggaagccg     1200

cccttcctga cccagctcca ctcctgcttc cagaccatgg accgcctgta ctttgtgatg     1260

gagtacgtga atgggggcga cctcatgtat cacatccagc aagtcggccg gttcaaggag     1320

ccccatgctg tattttacgc tgcagaaatt gccatcggtc tgttcttctt acagagtaag     1380

ggcatcattt accgtgacct aaaacttgac aacgtgatgc tcgattctga gggacacatc     1440

aagattgccg attttggcat gtgtaaggaa aacatctggg atggggtgac aaccaagaca     1500

ttctgtggca ctccagacta catcgccccc gagataattg cttatcagcc ctatgggaag     1560

tccgtggatt ggtgggcatt tggagtcctg ctgtatgaaa tgttggctgg gcaggcaccc     1620

tttgaagggg aggatgaaga tgaactcttc caatccatca tggaacacaa cgtagcctat     1680

cccaagtcta tgtccaagga agctgtggcc atctgcaaag ggctgatgac caaacaccca     1740

ggcaaacgtc tgggttgtgg acctgaaggc gaacgtgata tcaaagagca tgcatttttc     1800

cggtatattg attgggagaa acttgaacgc aaagagatcc agccccctta taagccaaaa     1860

gctagagaca agagagacac ctccaacttc gacaaagagt tcaccagaca gcctgtggaa     1920

ctgaccccca ctgataaact cttcatcatg aacttggacc aaaatgaatt tgctggcttc     1980

tcttatacta acccagagtt tgtcattaat gtgtag                               2016


<210>  786
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  787
<211>  1032
<212>  DNA
<213>  Homo sapiens

<400>  787
atggcccaga agggggtcct ggggcctggg cagctggggg ctgtggccat tctgctctat       60

cttggattac tccggtcggg gacaggagcg gaaggggcag aagctccctg cggtgtggcc      120

ccccaagcac gcatcacagg tggcagcagt gcagtcgccg gtcagtggcc ctggcaggtc      180

agcatcacct atgaaggcgt ccatgtgtgt ggtggctctc tcgtgtctga gcagtgggtg      240

ctgtcagctg ctcactgctt ccccagcgag caccacaagg aagcctatga ggtcaagctg      300

ggggcccacc agctagactc ctactccgag gacgccaagg tcagcaccct gaaggacatc      360

atcccccacc ccagctacct ccaggagggc tcccagggcg acattgcact cctccaactc      420

agcagaccca tcaccttctc ccgctacatc cggcccatct gcctccctgc agccaacgcc      480

tccttcccca acggcctcca ctgcactgtc actggctggg gtcatgtggc cccctcagtg      540

agcctcctga cgcccaagcc actgcagcaa ctcgaggtgc ctctgatcag tcgtgagacg      600

tgtaactgcc tgtacaacat cgacgccaag cctgaggagc cgcactttgt ccaagaggac      660

atggtgtgtg ctggctatgt ggaggggggc aaggacgcct gccagggtga ctctgggggc      720

ccactctcct gccctgtgga gggtctctgg tacctgacgg gcattgtgag ctggggagat      780

gcctgtgggg cccgcaacag gcctggtgtg tacactctgg cctccagcta tgcctcctgg      840

atccaaagca aggtgacaga actccagcct cgtgtggtgc cccaaaccca ggagtcccag      900

cccgacagca acctctgtgg cagccacctg gccttcagct ctgccccagc ccagggcttg      960

ctgaggccca tccttttcct gcctctgggc ctggctctgg gcctcctctc cccatggctc     1020

agcgagcact ga                                                         1032


<210>  788
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Ala Gln Lys Gly Val Leu Gly Pro Gly Gln Leu Gly Ala Val Ala 
1               5                   10                  15      


Ile Leu Leu Tyr Leu Gly Leu Leu Arg Ser Gly Thr Gly Ala Glu Gly 
            20                  25                  30          


Ala Glu Ala Pro Cys Gly Val Ala Pro Gln Ala Arg Ile Thr Gly Gly 
        35                  40                  45              


Ser Ser Ala Val Ala Gly Gln Trp Pro Trp Gln Val Ser Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Val His Val Cys Gly Gly Ser Leu Val Ser Glu Gln Trp Val 
65                  70                  75                  80  


Leu Ser Ala Ala His Cys Phe Pro Ser Glu His His Lys Glu Ala Tyr 
                85                  90                  95      


Glu Val Lys Leu Gly Ala His Gln Leu Asp Ser Tyr Ser Glu Asp Ala 
            100                 105                 110         


Lys Val Ser Thr Leu Lys Asp Ile Ile Pro His Pro Ser Tyr Leu Gln 
        115                 120                 125             


Glu Gly Ser Gln Gly Asp Ile Ala Leu Leu Gln Leu Ser Arg Pro Ile 
    130                 135                 140                 


Thr Phe Ser Arg Tyr Ile Arg Pro Ile Cys Leu Pro Ala Ala Asn Ala 
145                 150                 155                 160 


Ser Phe Pro Asn Gly Leu His Cys Thr Val Thr Gly Trp Gly His Val 
                165                 170                 175     


Ala Pro Ser Val Ser Leu Leu Thr Pro Lys Pro Leu Gln Gln Leu Glu 
            180                 185                 190         


Val Pro Leu Ile Ser Arg Glu Thr Cys Asn Cys Leu Tyr Asn Ile Asp 
        195                 200                 205             


Ala Lys Pro Glu Glu Pro His Phe Val Gln Glu Asp Met Val Cys Ala 
    210                 215                 220                 


Gly Tyr Val Glu Gly Gly Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
225                 230                 235                 240 


Pro Leu Ser Cys Pro Val Glu Gly Leu Trp Tyr Leu Thr Gly Ile Val 
                245                 250                 255     


Ser Trp Gly Asp Ala Cys Gly Ala Arg Asn Arg Pro Gly Val Tyr Thr 
            260                 265                 270         


Leu Ala Ser Ser Tyr Ala Ser Trp Ile Gln Ser Lys Val Thr Glu Leu 
        275                 280                 285             


Gln Pro Arg Val Val Pro Gln Thr Gln Glu Ser Gln Pro Asp Ser Asn 
    290                 295                 300                 


Leu Cys Gly Ser His Leu Ala Phe Ser Ser Ala Pro Ala Gln Gly Leu 
305                 310                 315                 320 


Leu Arg Pro Ile Leu Phe Leu Pro Leu Gly Leu Ala Leu Gly Leu Leu 
                325                 330                 335     


Ser Pro Trp Leu Ser Glu His 
            340             


<210>  789
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  789
atggaggacc ccacgctcta tattgtcgag cggccgcttc ccgggtaccc cgacgccgag       60

gccccggagc cttcctccgc tggggctcag gcagcggagg agccgtcggg ggccggctca      120

gaagagctga tcaagtcgga ccaggtgaac ggcgtgctgg tgctgagcct cctggacaaa      180

atcatcgggg ccgtagacca gatccagctg actcaagcac agctggagga gcggcaggcg      240

gagatggagg gcgcagtgca gagcatccag ggcgagctga gcaagctggg caaggcgcac      300

gccaccacga gcaatacggt gagcaagctg ctggagaagg tgcgcaaggt cagcgtcaac      360

gtgaagaccg tgcgcggcag cctggagcgc caggcggggc agatcaagaa gctggaggtc      420

aacgaggccg agctgctgcg gcgccgcaac tttaaagtca tgatctacca ggatgaagtg      480

aagctgccgg ccaaactgag catcagcaaa tcgctgaaag agtcggaggc gctgccagag      540

aaggagggcg aggagctggg cgagggcgag cggcccgagg aggacgcagc ggcgctggag      600

ctttcgtcgg acgaggcggt ggaggttgag gaggttattg aggagtcccg cgcagagcgt      660

atcaagcgca gcggcctgcg gcgcgtggac gacttcaaga aggccttctc caaggagaag      720

atggagaaga ccaaggtgcg tacccgcgag aacctggaga agacgcgcct caagaccaag      780

gaaaacctgg agaagacgcg gcacaccctg gagaagcgca tgaacaagct gggcacgcgc      840

ctggtgcccg ccgagcggcg cgagaaactg aagacgtcgc gggacaagtt gcgcaaatcc      900

ttcacgcccg accacgtggt gtacgcgcgc tccaagaccg cggtctacaa ggtgccaccc      960

ttcaccttcc acgtcaagaa gatccgcgag ggccaggtgg aagtgctcaa ggccaccgag     1020

atggtggagg tgggcgccga cgacgacgag ggcggcgcgg agcgcgggga ggccggcgac     1080

ctgcggcgcg ggagcagccc cgacgtgcac gcgctgctgg agatcaccga ggagtcggac     1140

gccgtgctgg tggacaagag cgacagcgac tga                                  1173


<210>  790
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  790

Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr 
1               5                   10                  15      


Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln 
        35                  40                  45              


Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala 
    50                  55                  60                  


Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala 
65                  70                  75                  80  


Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu 
                85                  90                  95      


Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu 
            100                 105                 110         


Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu 
        115                 120                 125             


Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu 
    130                 135                 140                 


Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val 
145                 150                 155                 160 


Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu 
                165                 170                 175     


Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro 
            180                 185                 190         


Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu 
        195                 200                 205             


Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser 
    210                 215                 220                 


Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys 
225                 230                 235                 240 


Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg 
                245                 250                 255     


Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys 
            260                 265                 270         


Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu 
        275                 280                 285             


Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp 
    290                 295                 300                 


His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro 
305                 310                 315                 320 


Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu 
                325                 330                 335     


Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly 
            340                 345                 350         


Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp 
        355                 360                 365             


Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val 
    370                 375                 380                 


Asp Lys Ser Asp Ser Asp 
385                 390 


<210>  791
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  791
atgggcaccc gcgacgacga gtacgactac ctctttaaag ttgtccttat tggagattct       60

ggtgttggaa agagtaatct cctgtctcga tttactcgaa atgagtttaa tctggaaagc      120

aagagcacca ttggagtaga gtttgcaaca agaagcatcc aggttgatgg aaaaacaata      180

aaggcacaga tatgggacac agcagggcaa gagcgatatc gagctataac atcagcatat      240

tatcgtggag ctgtaggtgc cttattggtt tatgacattg ctaaacatct cacatatgaa      300

aatgtagagc gatggctgaa agaactgaga gatcatgctg atagtaacat tgttatcatg      360

cttgtgggca ataagagtga tctacgtcat ctcagggcag ttcctacaga tgaagcaaga      420

gcttttgcag aaaagaatgg tttgtcattc attgaaactt cggccctaga ctctacaaat      480

gtagaagctg cttttcagac aattttaaca gagatttacc gcattgtttc tcagaagcaa      540

atgtcagaca gacgcgaaaa tgacatgtct ccaagcaaca atgtggttcc tattcatgtt      600

ccaccaacca ctgaaaacaa gccaaaggtg cagtgctgtc agaacatcta a               651


<210>  792
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  792

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  793
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  793
atgtctgatg gagattatga ttacctcatc aagtttttag ctttgggaga ctctggtgta       60

gggaagacca gtgtacttta ccaatataca gatggtaaat ttaactccaa atttatcaca      120

acagtgggca ttgatttcag ggaaaaaaga gtggtgtaca gagccagtgg gccggatgga      180

gccactggca gaggccagag aatccacctg cagttatggg acacagcagg gcaggagagg      240

tttcgtagct taacgacagc gttcttcaga gatgctatgg gttttcttct actttttgat      300

ctgacaaatg agcaaagttt cctcaatgtc agaaactgga taagccagct acagatgcat      360

gcatattgtg aaaacccaga tatagtgctg tgtggaaaca agagtgatct ggaggaccag      420

agagtagtga aagaggagga agccatagca ctcgcagaga aatatggaat cccctacttt      480

gaaactagtg ctgccaatgg gacaaacata agccaagcaa ttgagatgct tctggacctg      540

ataatgaagc gaatggaacg gtgtgtggac aagtcctgga ttcctgaagg agtggtgcga      600

tcaaatggtc atgcctctac ggatcagtta agtgaagaaa aggagaaagg ggcatgtggc      660

tgttga                                                                 666


<210>  794
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210>  795
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  795
atgtccgaaa cctacgattt tttgtttaag ttcttggtta ttggaaatgc aggaactggc       60

aaatcttgct tacttcatca gtttattgaa aaaaaattca aagatgactc aaatcataca      120

ataggagtgg aatttggttc aaagataata aatgttggtg gtaaatatgt aaagttacaa      180

atatgggata cagcaggaca agaacgattc aggtccgtga cgagaagtta ttaccgaggc      240

gcggccgggg ctctcctcgt ctatgatatc accagccgag aaacctacaa tgcgcttact      300

aattggttaa cagatgcccg aatgctagcg agccagaaca ttgtgatcat cctttgtgga      360

aacaagaagg acctggatgc agatcgtgaa gttaccttct tagaagcctc cagatttgct      420

caagaaaatg agctgatgtt tttggaaaca agtgcgctca caggggaaga tgtagaagag      480

gcttttgtac agtgtgcaag aaaaatactt aacaaaatcg aatcaggtga gctggaccca      540

gaaagaatgg gctcaggtat tcagtacgga gatgctgcct tgagacagct gaggtcaccg      600

cggcgcaccc aggccccgaa cgctcaggag tgtggttgtt ag                         642


<210>  796
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  796

Met Ser Glu Thr Tyr Asp Phe Leu Phe Lys Phe Leu Val Ile Gly Asn 
1               5                   10                  15      


Ala Gly Thr Gly Lys Ser Cys Leu Leu His Gln Phe Ile Glu Lys Lys 
            20                  25                  30          


Phe Lys Asp Asp Ser Asn His Thr Ile Gly Val Glu Phe Gly Ser Lys 
        35                  40                  45              


Ile Ile Asn Val Gly Gly Lys Tyr Val Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Ser Val Thr Arg Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Ala Gly Ala Leu Leu Val Tyr Asp Ile Thr Ser Arg Glu Thr Tyr 
                85                  90                  95      


Asn Ala Leu Thr Asn Trp Leu Thr Asp Ala Arg Met Leu Ala Ser Gln 
            100                 105                 110         


Asn Ile Val Ile Ile Leu Cys Gly Asn Lys Lys Asp Leu Asp Ala Asp 
        115                 120                 125             


Arg Glu Val Thr Phe Leu Glu Ala Ser Arg Phe Ala Gln Glu Asn Glu 
    130                 135                 140                 


Leu Met Phe Leu Glu Thr Ser Ala Leu Thr Gly Glu Asp Val Glu Glu 
145                 150                 155                 160 


Ala Phe Val Gln Cys Ala Arg Lys Ile Leu Asn Lys Ile Glu Ser Gly 
                165                 170                 175     


Glu Leu Asp Pro Glu Arg Met Gly Ser Gly Ile Gln Tyr Gly Asp Ala 
            180                 185                 190         


Ala Leu Arg Gln Leu Arg Ser Pro Arg Arg Thr Gln Ala Pro Asn Ala 
        195                 200                 205             


Gln Glu Cys Gly Cys 
    210             


<210>  797
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  797
atggctgcaa ataagcccaa gggtcagaat tctttggctt tacacaaagt catcatggtg       60

ggcagtggtg gcgtgggcaa gtcagctctg actctacagt tcatgtacga tgagtttgtg      120

gaggactatg agcctaccaa agcagacagc tatcggaaga aggtagtgct agatggggag      180

gaagtccaga tcgatatctt agatacagct gggcaggagg actacgctgc aattagagac      240

aactacttcc gaagtgggga ggggttcctc tgtgttttct ctattacaga aatggaatcc      300

tttgcagcta cagctgactt cagggagcag attttaagag taaaagaaga tgagaatgtt      360

ccatttctac tggttggtaa caaatcagat ttagaagata aaagacaggt ttctgtagaa      420

gaggcaaaaa acagagctga gcagtggaat gttaactacg tggaaacatc tgctaaaaca      480

cgagctaatg ttgacaaggt attttttgat ttaatgagag aaattcgagc gagaaagatg      540

gaagacagca aagaaaagaa tggaaaaaag aagaggaaaa gtttagccaa gagaatcaga      600

gaaagatgct gcattttata a                                                621


<210>  798
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Ala Ala Asn Lys Pro Lys Gly Gln Asn Ser Leu Ala Leu His Lys 
1               5                   10                  15      


Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
            20                  25                  30          


Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
        35                  40                  45              


Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
65                  70                  75                  80  


Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Cys Val Phe Ser Ile Thr 
                85                  90                  95      


Glu Met Glu Ser Phe Ala Ala Thr Ala Asp Phe Arg Glu Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Glu Asp Glu Asn Val Pro Phe Leu Leu Val Gly Asn Lys 
        115                 120                 125             


Ser Asp Leu Glu Asp Lys Arg Gln Val Ser Val Glu Glu Ala Lys Asn 
    130                 135                 140                 


Arg Ala Glu Gln Trp Asn Val Asn Tyr Val Glu Thr Ser Ala Lys Thr 
145                 150                 155                 160 


Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile Arg 
                165                 170                 175     


Ala Arg Lys Met Glu Asp Ser Lys Glu Lys Asn Gly Lys Lys Lys Arg 
            180                 185                 190         


Lys Ser Leu Ala Lys Arg Ile Arg Glu Arg Cys Cys Ile Leu 
        195                 200                 205     


<210>  799
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  799
atggccgaca aggaagcagc cttcgacgac gcagtggaag aacgagtgat caacgaggaa       60

tacaaaatat ggaaaaagaa cacccctttt ctttatgatt tggtgatgac ccatgctctg      120

gagtggccca gcctaactgc ccagtggctt ccagatgtaa ccagaccaga agggaaagat      180

ttcagcattc atcgacttgt cctggggaca cacacatcgg atgaacaaaa ccatcttgtt      240

atagccagtg tgcagctccc taatgatgat gctcagtttg atgcgtcaca ctacgacagt      300

gagaaaggag aatttggagg ttttggttca gttagtggaa aaattgaaat agaaatcaag      360

atcaaccatg aaggagaagt aaacagggcc cgttatatgc cccagaaccc ttgtatcatc      420

gcaacaaaga ctccttccag tgatgttctt gtttttgact atacaaaaca tccttctaaa      480

ccagatcctt ctggagagtg caacccagac ttgcgtctcc gtggacatca gaaggaaggc      540

tatgggcttt cttggaaccc aaatctcagt gggcacttac ttagtgcttc agatgaccat      600

accatctgcc tgtgggacat cagtgccgtt ccaaaggagg gaaaagtggt agatgcgaag      660

accatcttta cagggcatac ggcagtagta gaagatgttt cctggcatct actccatgag      720

tctctgtttg ggtcagttgc tgatgatcag aaacttatga tttgggatac tcgttcaaac      780

aatacttcca aaccaagcca ctcagttgat gctcacactg ctgaagtgaa ctgcctttct      840

ttcaatcctt atagtgagtt cattcttgcc acaggatcag ctgacaagac tgttgccttg      900

tgggatctga gaaatctgaa acttaagttg cattcctttg agtcacataa ggatgaaata      960

ttccaggttc agtggtcacc tcacaatgag actattttag cttccagtgg tactgatcgc     1020

agactgaatg tctgggattt aagtaaaatt ggagaggaac aatccccaga agatgcagaa     1080

gacgggccac cagagttgtt gtttattcat ggtggtcata ctgccaagat atctgatttc     1140

tcctggaatc ccaatgaacc ttgggtgatt tgttctgtat cagaagacaa tatcatgcaa     1200

gtgtggcaaa tggcagagaa catttataat gatgaagacc ctgaaggaag cgtggatcca     1260

gaaggacaag ggtcctag                                                   1278


<210>  800
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  800

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15      


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30          


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45              


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60                  


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80  


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95      


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110         


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125             


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140                 


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160 


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175     


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190         


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205             


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220                 


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240 


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255     


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270         


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285             


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300                 


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320 


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335     


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350         


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365             


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380                 


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400 


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415     


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425 


<210>  801
<211>  4167
<212>  DNA
<213>  Homo sapiens

<400>  801
atgagccggc ccccgccgac ggggaaaatg cccggcgccc ccgagaccgc gccgggggac       60

ggggcaggcg cgagccgcca gaggaagctg gaggcgctga tccgagaccc tcgctccccc      120

atcaacgtgg agagcttgct ggatggctta aattccttgg tccttgattt agattttcct      180

gctttgagga aaaacaagaa catagataat ttcttaaata gatatgagaa aattgtgaaa      240

aaaatcagag gtctacagat gaaggcagaa gactatgatg ttgtaaaagt tattggaaga      300

ggtgcttttg gtgaagtgca gttggttcgt cacaaggcat cgcagaaggt ttatgctatg      360

aagcttctta gtaagtttga aatgataaaa agatcagatt ctgccttttt ttgggaagaa      420

agagatatta tggcctttgc caatagcccc tgggtggttc agctttttta tgcctttcaa      480

gatgataggt atctgtacat ggtaatggag tacatgcctg gtggagacct tgtaaacctt      540

atgagtaatt atgatgtgcc tgaaaaatgg gccaaatttt acactgctga agttgttctt      600

gctctggatg caatacactc catgggttta atacacagag atgtgaagcc tgacaacatg      660

ctcttggata aacatggaca tctaaaatta gcagattttg gcacgtgtat gaagatggat      720

gaaacaggca tggtacattg tgatacagca gttggaacac cggattatat atcacctgag      780

gttctgaaat cacaaggggg tgatggtttc tatgggcgag aatgtgattg gtggtctgta      840

ggtgttttcc tttatgagat gctagtgggg gatactccat tttatgcgga ttcacttgta      900

ggaacatata gcaaaattat ggatcataag aattcactgt gtttccctga agatgcagaa      960

atttccaaac atgcaaagaa tctcatctgt gctttcttaa cagataggga ggtacgactt     1020

gggagaaatg gggtggaaga aatcagacag catcctttct ttaagaatga tcagtggcat     1080

tgggataaca taagagaaac ggcagctcct gtagtacctg aactcagcag tgacatagac     1140

agcagcaatt tcgatgacat tgaagatgac aaaggagatg tagaaacctt cccaattcct     1200

aaagcttttg ttggaaatca gctgcctttc atcggattta cctactatag agaaaattta     1260

ttattaagtg actctccatc ttgtagagaa actgattcca tacaatcaag gaaaaatgaa     1320

gaaagtcaag agattcagaa aaaactgtat acattagaag aacatcttag caatgagatg     1380

caagccaaag aggaactgga acagaagtgc aaatctgtta atactcgcct agaaaaaaca     1440

gcaaaggagc tagaagagga gattacctta cggaaaagtg tggaatcagc attaagacag     1500

ttagaaagag aaaaggcgct tcttcagcac aaaaatgcag aatatcagag gaaagctgat     1560

catgaagcag acaaaaaacg aaatttggaa aatgatgtta acagcttaaa agatcaactt     1620

gaagatttga aaaaaagaaa tcaaaactct caaatatcca ctgagaaagt gaatcaactc     1680

cagagacaac tggatgaaac caatgcttta ctgcgaacag agtctgatac tgcagcccgg     1740

ttaaggaaaa cccaggcaga aagttcaaaa cagattcagc agctggaatc taacaataga     1800

gatctacaag ataaaaactg cctgctggag actgccaagt taaaacttga aaaggaattt     1860

atcaatcttc agtcagctct agaatctgaa aggagggatc gaacccatgg atcagagata     1920

attaatgatt tacaaggtag aatatgtggc ctagaagaag atttaaagaa cggcaaaatc     1980

ttactagcga aagtagaact ggagaagaga caacttcagg agagatttac tgatttggaa     2040

aaggaaaaaa gcaacatgga aatagatatg acataccaac taaaagttat acagcagagc     2100

ctagaacaag aagaagctga acataaggcc acaaaggcac gactagcaga taaaaataag     2160

atctatgagt ccatcgaaga agccaaatca gaagccatga aagaaatgga gaagaagctc     2220

ttggaggaaa gaactttaaa acagaaagtg gagaacctat tgctagaagc tgagaaaaga     2280

tgttctctat tagactgtga cctcaaacag tcacagcaga aaataaatga gctccttaaa     2340

cagaaagatg tgctaaatga ggatgttaga aacctgacat taaaaataga gcaagaaact     2400

cagaagcgct gccttacaca aaatgacctg aagatgcaaa cacaacaggt taacacacta     2460

aaaatgtcag aaaagcagtt aaagcaagaa aataaccatc tcatggaaat gaaaatgaac     2520

ttggaaaaac aaaatgctga acttcgaaaa gaacgtcagg atgcagatgg gcaaatgaaa     2580

gagctccagg atcagctcga agcagaacag tatttctcaa ccctttataa aacacaagtt     2640

agggagctta aagaagaatg tgaagaaaag accaaacttg gtaaagaatt gcagcagaag     2700

aaacaggaat tacaggatga acgggactct ttggctgccc aactggagat caccttgacc     2760

aaagcagatt ctgagcaact ggctcgttca attgctgaag aacaatattc tgatttggaa     2820

aaagagaaga tcatgaaaga gctggagatc aaagagatga tggctagaca caaacaggaa     2880

cttacggaaa aagatgctac aattgcttct cttgaggaaa ctaataggac actaactagt     2940

gatgttgcca atcttgcaaa tgagaaagaa gaattaaata acaaattgaa agatgttcaa     3000

gagcaactgt caagattgaa agatgaagaa ataagcgcag cagctattaa agcacagttt     3060

gagaagcagc tattaacaga aagaacactc aaaactcaag ctgtgaataa gttggctgag     3120

atcatgaatc gaaaagaacc tgtcaagcgt ggtaatgaca cagatgtgcg gagaaaagag     3180

aaggagaata gaaagctaca tatggagctt aaatctgaac gtgagaaatt gacccagcag     3240

atgatcaagt atcagaaaga actgaatgaa atgcaggcac aaatagctga agagagccag     3300

attcgaattg aactgcagat gacattggac agtaaagaca gtgacattga gcagctgcgg     3360

tcacaactcc aagccttgca tattggtctg gatagttcca gtataggcag tggaccaggg     3420

gatgctgagg cagatgatgg gtttccagaa tcaagattag aaggatggct ttcattgcct     3480

gtacgaaaca acactaagaa atttggatgg gttaaaaagt atgtgattgt aagcagtaag     3540

aagattcttt tctatgacag tgaacaagat aaagaacaat ccaatcctta catggtttta     3600

gatatagaca agttatttca tgtccgacca gttacacaga cagatgtgta tagagcagat     3660

gctaaagaaa ttccaaggat attccagatt ctgtatgcca atgaaggaga aagtaagaag     3720

gaacaagaat ttccagtgga gccagttgga gaaaaatcta attatatttg ccacaaggga     3780

catgagttta ttcctactct ttatcatttc ccaaccaact gtgaggcttg tatgaagccc     3840

ctgtggcaca tgtttaagcc tcctcctgct ttggagtgcc gccgttgcca tattaagtgt     3900

cataaagatc atatggacaa aaaggaggag attatagcac cttgcaaagt atattatgat     3960

atttcaacgg caaagaatct gttattacta gcaaattcta cagaagagca gcagaagtgg     4020

gttagtcggt tggtgaaaaa gatacctaaa aagcccccag ctccagaccc ttttgcccga     4080

tcatctccta gaacttcaat gaagatacag caaaaccagt ctattagacg gccaagtcga     4140

cagcttgccc caaacaaacc tagctaa                                         4167


<210>  802
<211>  1388
<212>  PRT
<213>  Homo sapiens

<400>  802

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  803
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  803
atgaatggtg ccccttcccc agaggacggg gcctccccct cgtctccccc gctgccccca       60

cccccgcccc ctagttggcg ggagttctgt gagtcccacg cccgggctgc ggctctggac      120

tttgcccgcc gttttcgcct ctacctggcc tcccaccccc aatatgcggg gcccggggcc      180

gaggctgcct tctcccgccg ttttgctgag ctcttcctgc agcactttga agccgaggtg      240

gcccgggcct ctggctccct gtcgccaccc atcctggctc ccctgagccc tggtgcggag      300

atttcgccac atgacctgtc ccttgagagc tgcagggtgg gtgggcccct ggctgtgctg      360

ggcccttctc gatcatctga ggacctggcc ggccccctcc cttcctcagt ctcttcctcc      420

tctacaacct cctccaagcc gaagctcaag aagcgctttt ccctgcgttc agtgggtcgc      480

tctgtccgag gctcagtccg tggcatcctg cagtggcggg ggaccgttga ccctccctcc      540

tccgctgggc ccctggagac ctcgtcaggc ccccctgtct taggtggaaa cagcaactcc      600

aactcctctg gcggggctgg gaccgttggt aggggactgg tcagtgatgg aacgtcccct      660

ggggaaagat ggactcaccg ttttgagagg ctgagactca gtcggggagg gggcgccttg      720

aaggatggag cagggatggt gcagagggaa gagctgctga gtttcatggg ggctgaggag      780

gcagcccctg acccagccgg agtgggccgg ggaggagggg tggctgggcc tccttcaggg      840

ggaggagggc agcctcagtg gcagaagtgt cgcctgctgc ttcgaagtga aggagaagga      900

ggaggaggaa gtcgcctgga gttctttgta ccacccaagg cctctcggcc ccgactcagc      960

atcccctgct cttctatcac agacgtccgg acaaccacag ccctggagat gcctgaccgg     1020

gagaacacgt ttgtggttaa ggtggaaggt ccatccgagt atatcatgga gacagtggat     1080

gcccagcatg tgaaggcctg ggtgtctgac atccaagaat gcctgagccc aggaccctgc     1140

cctgccacca gtccccgccc catgaccctc cctctggccc ctgggacctc attccttaca     1200

agggagaaca cagacagcct ggagctgtcc tgcctgaatc actcggagag tttacccagc     1260

caggacctgc tgcttggacc cagcgagagc aatgaccgcc tgtcgcaggg ggcatatggg     1320

ggcctctcag accgcccctc ggcatccatc tcccccagct ctgcctccat tgccgcctcc     1380

cattttgact cgatggaact gcttccccca gagttgcccc cccgcatccc cattgaagag     1440

ggacccccag cagggacagt tcatcccctc tcagccccct accctccctt ggacactccg     1500

gaaacagcca cagggtcctt cctgttccag ggggagccag agggcggtga gggggaccag     1560

cccctctcag ggtatccttg gttccacggg atgctctctc ggctcaaggc tgcacagttg     1620

gtgctgactg gcggcactgg ctcccacggt gtcttcctgg tgcgccagag tgagacaagg     1680

cggggtgaat acgtcctcac cttcaacttc cagggcaagg ccaagcacct gcgtttgtcg     1740

ctgaacgagg agggtcagtg ccgggtccag cacctgtggt tccagtccat tttcgatatg     1800

ctcgagcact tccgggtgca ccccatccct ttggagtcgg gaggctccag tgatgttgtc     1860

cttgtcagct atgtcccatc ctcccagcga cagcaggaac cgaccacctc ccatgaccca     1920

ccccagcccc ctgaaccccc ttcatggaca gatcccccac agcctggggc agaagaggcg     1980

tcgagggcgc cagaagtggc ggcagcagca gccgcagcag ccaaagagag gcaagagaaa     2040

gagaaagcgg gcggtggagg ggtcccggaa gagctggtcc ccgtggttga gctggtcccc     2100

gtggttgaat tggaagaggc catagcccca ggctcagagg cccagggcgc tgggtctggt     2160

ggggacgcgg gggtgccccc aatggtgcag ctgcagcagt caccactagg gggtgatgga     2220

gaggaagggg gccaccccag ggccattaac aaccagtact ccttcgtgtg a              2271


<210>  804
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  804

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Ala Ser Pro Ser Ser Pro 
1               5                   10                  15      


Pro Leu Pro Pro Pro Pro Pro Pro Ser Trp Arg Glu Phe Cys Glu Ser 
            20                  25                  30          


His Ala Arg Ala Ala Ala Leu Asp Phe Ala Arg Arg Phe Arg Leu Tyr 
        35                  40                  45              


Leu Ala Ser His Pro Gln Tyr Ala Gly Pro Gly Ala Glu Ala Ala Phe 
    50                  55                  60                  


Ser Arg Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
65                  70                  75                  80  


Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Ile Leu Ala Pro Leu Ser 
                85                  90                  95      


Pro Gly Ala Glu Ile Ser Pro His Asp Leu Ser Leu Glu Ser Cys Arg 
            100                 105                 110         


Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu Asp 
        115                 120                 125             


Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Ser Thr Thr Ser 
    130                 135                 140                 


Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
145                 150                 155                 160 


Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Thr Val 
                165                 170                 175     


Asp Pro Pro Ser Ser Ala Gly Pro Leu Glu Thr Ser Ser Gly Pro Pro 
            180                 185                 190         


Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
        195                 200                 205             


Val Gly Arg Gly Leu Val Ser Asp Gly Thr Ser Pro Gly Glu Arg Trp 
    210                 215                 220                 


Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Ala Leu 
225                 230                 235                 240 


Lys Asp Gly Ala Gly Met Val Gln Arg Glu Glu Leu Leu Ser Phe Met 
                245                 250                 255     


Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
            260                 265                 270         


Gly Val Ala Gly Pro Pro Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
        275                 280                 285             


Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
    290                 295                 300                 


Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
305                 310                 315                 320 


Ile Pro Cys Ser Ser Ile Thr Asp Val Arg Thr Thr Thr Ala Leu Glu 
                325                 330                 335     


Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
            340                 345                 350         


Glu Tyr Ile Met Glu Thr Val Asp Ala Gln His Val Lys Ala Trp Val 
        355                 360                 365             


Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Thr Ser 
    370                 375                 380                 


Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
385                 390                 395                 400 


Arg Glu Asn Thr Asp Ser Leu Glu Leu Ser Cys Leu Asn His Ser Glu 
                405                 410                 415     


Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
            420                 425                 430         


Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
        435                 440                 445             


Ser Ile Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
    450                 455                 460                 


Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
465                 470                 475                 480 


Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Ala Pro Tyr Pro Pro 
                485                 490                 495     


Leu Asp Thr Pro Glu Thr Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
            500                 505                 510         


Pro Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
        515                 520                 525             


His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Thr Gly 
    530                 535                 540                 


Gly Thr Gly Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
545                 550                 555                 560 


Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                565                 570                 575     


Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
            580                 585                 590         


Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
        595                 600                 605             


Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
    610                 615                 620                 


Val Pro Ser Ser Gln Arg Gln Gln Glu Pro Thr Thr Ser His Asp Pro 
625                 630                 635                 640 


Pro Gln Pro Pro Glu Pro Pro Ser Trp Thr Asp Pro Pro Gln Pro Gly 
                645                 650                 655     


Ala Glu Glu Ala Ser Arg Ala Pro Glu Val Ala Ala Ala Ala Ala Ala 
            660                 665                 670         


Ala Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val 
        675                 680                 685             


Pro Glu Glu Leu Val Pro Val Val Glu Leu Val Pro Val Val Glu Leu 
    690                 695                 700                 


Glu Glu Ala Ile Ala Pro Gly Ser Glu Ala Gln Gly Ala Gly Ser Gly 
705                 710                 715                 720 


Gly Asp Ala Gly Val Pro Pro Met Val Gln Leu Gln Gln Ser Pro Leu 
                725                 730                 735     


Gly Gly Asp Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
            740                 745                 750         


Tyr Ser Phe Val 
        755     


<210>  805
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  805
atgtcgtcca tcttgccatt cacgccgcca gttgtgaaga gactgctggg atggaagaag       60

tcagctggtg ggtctggagg agcaggcgga ggagagcaga atgggcagga agaaaagtgg      120

tgtgagaaag cagtgaaaag tctggtgaag aagctaaaga aaacaggacg attagatgag      180

cttgagaaag ccatcaccac tcaaaactgt aatactaaat gtgttaccat accaagcact      240

tgctctgaaa tttggggact gagtacacca aatacgatag atcagtggga tacaacaggc      300

ctttacagct tctctgaaca aaccaggtct cttgatggtc gtctccaggt atcccatcga      360

aaaggattgc cacatgttat atattgccga ttatggcgct ggcctgatct tcacagtcat      420

catgaactca aggcaattga aaactgcgaa tatgctttta atcttaaaaa ggatgaagta      480

tgtgtaaacc cttaccacta tcagagagtt gagacaccag ttttgcctcc agtattagtg      540

ccccgacaca ccgagatcct aacagaactt ccgcctctgg atgactatac tcactccatt      600

ccagaaaaca ctaacttccc agcaggaatt gagccacaga gtaattatat tccagaaacg      660

ccacctcctg gatatatcag tgaagatgga gaaacaagtg accaacagtt gaatcaaagt      720

atggacacag gctctccagc agaactatct cctactactc tttcccctgt taatcatagc      780

ttggatttac agccagttac ttactcagaa cctgcatttt ggtgttcgat agcatattat      840

gaattaaatc agagggttgg agaaaccttc catgcatcac agccctcact cactgtagat      900

ggctttacag acccatcaaa ttcagagagg ttctgcttag gtttactctc caatgttaac      960

cgaaatgcca cggtagaaat gacaagaagg catataggaa gaggagtgcg cttatactac     1020

ataggtgggg aagtttttgc tgagtgccta agtgatagtg caatctttgt gcagagcccc     1080

aattgtaatc agagatatgg ctggcaccct gcaacagtgt gtaaaattcc accaggctgt     1140

aatctgaaga tcttcaacaa ccaggaattt gctgctcttc tggctcagtc tgttaatcag     1200

ggttttgaag ccgtctatca gctaactaga atgtgcacca taagaatgag ttttgtgaaa     1260

gggtggggag cagaataccg aaggcagacg gtaacaagta ctccttgctg gattgaactt     1320

catctgaatg gacctctaca gtggttggac aaagtattaa ctcagatggg atccccttca     1380

gtgcgttgct caagcatgtc ataa                                            1404


<210>  806
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  806

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
            20                  25                  30          


Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
        35                  40                  45              


Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
    50                  55                  60                  


Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
65                  70                  75                  80  


Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                85                  90                  95      


Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
            100                 105                 110         


Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
        115                 120                 125             


Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
    130                 135                 140                 


Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
145                 150                 155                 160 


Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                165                 170                 175     


Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
            180                 185                 190         


Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
        195                 200                 205             


Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
    210                 215                 220                 


Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
225                 230                 235                 240 


Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                245                 250                 255     


Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
            260                 265                 270         


Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
        275                 280                 285             


Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
    290                 295                 300                 


Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
305                 310                 315                 320 


Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                325                 330                 335     


Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
            340                 345                 350         


Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
        355                 360                 365             


His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
    370                 375                 380                 


Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
385                 390                 395                 400 


Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                405                 410                 415     


Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
            420                 425                 430         


Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
        435                 440                 445             


Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
    450                 455                 460                 


Ser Met Ser 
465         


<210>  807
<211>  4944
<212>  DNA
<213>  Homo sapiens

<400>  807
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgagagcaga     3780

cactgcagca cgggcagcgg cagtgccagc ttcgcccaca ctgcccctcc gccagcgggc     3840

gtcaaccccg acttggagga gccacctcta aaggaggaag acgaggtgcc cgacgacgag     3900

accgtcaacc agatgatcgc ccggcacgag gaggagtttg atctgttcat gcgcatggac     3960

ctggaccgca ggcgcgagga ggcccgcaac cccaagcgga agccgcgcct catggaggag     4020

gacgagctcc cctcgtggat catcaaggac gacgcggagg tggagcggct gacctgtgag     4080

gaggaggagg agaagatgtt cggccgtggc tcccgccacc gcaaggaggt ggactacagc     4140

gactcactga cggagaagca gtggctcaag gccatcgagg agggcacgct ggaggagatc     4200

gaagaggagg tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc     4260

tcctccaccc cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag     4320

aagaagcgcg ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag     4380

aagatgaaga agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag     4440

ctcagcgagg tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc     4500

atccgcaagc ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc     4560

agcctcaacg acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac     4620

ctggagggct ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg     4680

cggcagaaaa tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag     4740

ggcgaggagg aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc     4800

cggaaggaga aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc     4860

cgagccaagc cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca     4920

ggaagtggca gcgaagaaga ctga                                            4944


<210>  808
<211>  1647
<212>  PRT
<213>  Homo sapiens

<400>  808

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210>  809
<211>  3645
<212>  DNA
<213>  Homo sapiens

<400>  809
atggcggtgc ggaagaagga cggcggcccc aacgtgaagt actacgaggc cgcggacacc       60

gtgacccagt tcgacaacgt gcggctgtgg ctcggcaaga actacaagaa gtatatacaa      120

gctgaaccac ccaccaacaa gtccctgtct agcctggttg tacagttgct acaatttcag      180

gaagaagttt ttggcaaaca tgtcagcaat gcaccgctca ctaaactgcc gatcaaatgt      240

ttcctagatt tcaaagcggg aggctccttg tgccacattc ttgcagctgc ctacaaattc      300

aagagtgacc agggatggcg gcgttacgat ttccagaatc catcacgcat ggaccgcaat      360

gtggaaatgt ttatgaccat tgagaagtcc ttggtgcaga ataattgcct gtctcgacct      420

aacatttttc tgtgcccaga aattgagccc aaactactag ggaaattaaa ggacattatc      480

aagagacacc agggaacagt cactgaggat aagaacaatg cctcccatgt tgtgtatcct      540

gtcccgggga atctagaaga agaggaatgg gtacgaccag tcatgaagag ggataagcag      600

gttcttctgc actggggcta ctatcctgac agttacgaca cgtggatccc agcgagtgaa      660

attgaggcat ctgtggaaga tgctccaact cctgagaaac ctaggaaggt tcatgcaaag      720

tggatcctgg acaccgacac cttcaatgaa tggatgaatg aggaagacta tgaagtaaat      780

gatgacaaaa accctgtctc ccgccgaaag aagatttcag ccaagacact gacagatgag      840

gtgaacagcc cagattcaga tcgacgggac aagaaggggg gaaactataa gaagaggaag      900

cgctccccct ctccttcacc aaccccagaa gcaaagaaga aaaatgctaa gaaaggtccc      960

tcaacacctt acactaagtc aaagcgtggc cacagagaag aggagcaaga agacctgaca     1020

aaggacatgg acgagccctc accagtcccc aatgtagaag aggtgacact tcccaaaaca     1080

gtcaacacaa agaaagactc agagtcggcc ccagtcaaag gcggcaccat gaccgacctg     1140

gatgaacagg aagatgaaag catggagacg acgggcaagg atgaggatga gaacagtacg     1200

gggaacaagg gagagcagac caagaatcca gacctgcatg aggacaatgt gactgaacag     1260

acccaccaca tcatcattcc cagctacgct gcctggtttg actacaatag tgttcatgcc     1320

attgagcgga gggctctccc cgagttcttc aacggcaaga acaagtccaa gactccagag     1380

atctacctgg cctatcgaaa ctttatgatt gacacttacc gactgaaccc ccaagagtat     1440

cttacctcta ccgcctgccg ccgaaaccta gcgggtgatg tctgtgccat catgagggtc     1500

catgccttcc tagaacagtg gggtcttatt aactaccagg tggatgctga gagtcgacca     1560

accccaatgg ggcctccgcc tacctctcac ttccatgtct tggctgacac accatcaggg     1620

ctggtgcctc tgcagcccaa gacacctcag cagacctctg cttcccaaca aatgctcaac     1680

tttcctgaca aaggcaaaga gaaaccaaca gacatgcaaa actttgggct gcgcacagac     1740

atgtacacaa aaaagaatgt tccctccaag agcaaggctg cagccagtgc cactcgtgag     1800

tggacagaac aggaaaccct gcttctcctg gaggcactgg aaatgtacaa agatgactgg     1860

aacaaagtgt ccgagcatgt gggaagccgc acacaggacg agtgcatctt gcattttctt     1920

cgtcttccca ttgaagaccc atacctggag gactcagagg cctccctagg ccccctggcc     1980

taccaaccca tccccttcag tcagtcgggc aaccctgtta tgagcactgt tgccttcctg     2040

gcctctgtcg tcgatccccg agtcgcctct gctgctgcaa agtcagccct agaggagttc     2100

tccaaaatga aggaagaggt acccacggcc ttggtggagg cccatgttcg aaaagtggaa     2160

gaagcagcca aagtaacagg caaggcggac cctgccttcg gtctggaaag cagtggcatt     2220

gcaggaacca cctctgatga gcctgagcgg attgaggaga gcgggaatga cgaggctcgg     2280

gtggaaggcc aggccacaga tgagaagaag gagcccaagg aaccccgaga aggagggggt     2340

gctatagagg aggaagcaaa agagaaaacc agcgaggctc ccaagaagga tgaggagaaa     2400

gggaaagaag gcgacagtga gaaggagtcc gagaagagtg atggagaccc aatagtcgat     2460

cctgagaagg agaaggagcc aaaggaaggg caggaggaag tgctgaagga agtggtggag     2520

tctgaggggg aaaggaagac aaaggtggag cgggacattg gcgagggcaa cctctccacc     2580

gctgctgccg ccgccctggc cgccgccgca gtgaaagcta agcacttggc tgctgttgag     2640

gaaaggaaga tcaaatcttt ggtggccctg ctggtggaga cccagatgaa aaagttggag     2700

atcaaacttc ggcactttga ggagctggag actatcatgg accgggagcg agaagcactg     2760

gagtatcaga ggcagcagct cctggccgac agacaagcct tccacatgga gcagctgaag     2820

tatgcggaga tgagggctcg gcagcagcac ttccaacaga tgcaccaaca gcagcagcag     2880

ccaccaccag ccctgccccc aggctcccag cctatccccc caacaggggc tgctgggcca     2940

cccgcagtcc atggcttggc tgtggctcca gcctctgtag tccctgctcc tgctggcagt     3000

ggggcccctc caggaagttt gggcccttct gaacagattg ggcaggcagg gtcaactgca     3060

gggccacagc agcagcaacc agctggagcc ccccagcctg gggcagtccc accaggggtt     3120

cccccccctg gaccccatgg cccctcaccg ttccccaacc aacaaactcc tccctcaatg     3180

atgccagggg cagtgccagg cagcgggcac ccaggcgtgg cgggtaatgc tcctttgggt     3240

ttgccttttg gcatgccgcc tcctcctcct cctcctgctc catccatcat cccatttggt     3300

agtctagctg actccatcag tattaacctc cccgctcctc ctaacctgca tgggcatcac     3360

caccatctcc cgttcgcccc gggcactctc cccccaccta acctgcctgt gtccatggcg     3420

aaccctctac atcctaacct gccggcgacc accaccatgc catcttcctt gcctctcggg     3480

ccggggctcg gatccgccgc agcccaaagc cctgccattg tggcagctgt tcagggcaac     3540

ctcctgccca gtgccagccc actgccagac ccaggcaccc ccctgcctcc agaccccaca     3600

gccccgagcc caggcacggt cacccctgtg ccacctccac agtga                     3645


<210>  810
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  810

Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser 
            980                 985                 990         


Val Val Pro Ala Pro Ala Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Ser Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Gln  Gln Pro Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Gln  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Gly  Asn Ala Pro Leu Gly  Leu Pro Phe 
    1070                 1075                 1080             


Gly Met  Pro Pro Pro Pro Pro  Pro Pro Ala Pro Ser  Ile Ile Pro 
    1085                 1090                 1095             


Phe Gly  Ser Leu Ala Asp Ser  Ile Ser Ile Asn Leu  Pro Ala Pro 
    1100                 1105                 1110             


Pro Asn  Leu His Gly His His  His His Leu Pro Phe  Ala Pro Gly 
    1115                 1120                 1125             


Thr Leu  Pro Pro Pro Asn Leu  Pro Val Ser Met Ala  Asn Pro Leu 
    1130                 1135                 1140             


His Pro  Asn Leu Pro Ala Thr  Thr Thr Met Pro Ser  Ser Leu Pro 
    1145                 1150                 1155             


Leu Gly  Pro Gly Leu Gly Ser  Ala Ala Ala Gln Ser  Pro Ala Ile 
    1160                 1165                 1170             


Val Ala  Ala Val Gln Gly Asn  Leu Leu Pro Ser Ala  Ser Pro Leu 
    1175                 1180                 1185             


Pro Asp  Pro Gly Thr Pro Leu  Pro Pro Asp Pro Thr  Ala Pro Ser 
    1190                 1195                 1200             


Pro Gly  Thr Val Thr Pro Val  Pro Pro Pro Gln 
    1205                 1210                 


<210>  811
<211>  6645
<212>  DNA
<213>  Homo sapiens

<400>  811
atggcgacac ggagcagcag gagggagtcg cgactcccgt tcctattcac cctggtcgca       60

ctgctgccgc ccggagctct ctgcgaagtc tggacgcaga ggctgcacgg cggcagcgcg      120

cccttgcccc aggaccgggg cttcctcgtg gtgcagggcg acccgcgcga gctgcggctg      180

tgggcgcgcg gggatgccag gggggcgagc cgcgcggacg agaagccgct ccggaggaaa      240

cggagcgctg ccctgcagcc cgagcccatc aaggtgtacg gacaggttag tctgaatgat      300

tcccacaatc agatggtggt gcactgggct ggagagaaaa gcaacgtgat cgtggccttg      360

gcccgagata gcctggcatt ggcgaggccc aagagcagtg atgtgtacgt gtcttacgac      420

tatggaaaat cattcaagaa aatttcagac aagttaaact ttggcttggg aaataggagt      480

gaagctgtta tcgcccagtt ctaccacagc cctgcggaca acaagcggta catctttgca      540

gacgcttatg cccagtacct ctggatcacg tttgacttct gcaacactct tcaaggcttt      600

tccatcccat ttcgggcagc tgatctcctc ctacacagta aggcctccaa ccttctcttg      660

ggctttgaca ggtcccaccc caacaagcag ctgtggaagt cagatgactt tggccagacc      720

tggatcatga ttcaggaaca tgtcaagtcc ttttcttggg gaattgatcc ctatgacaaa      780

ccaaatacca tctacattga acgacatgaa ccctctggct actccactgt cttccgaagt      840

acagatttct tccagtcccg ggaaaaccag gaagtgatcc ttgaggaagt gagagatttt      900

cagcttcggg acaagtacat gtttgctaca aaggtggtgc atctcttggg cagtgaacag      960

cagtcttctg tccagctctg ggtctccttt ggccggaagc ccatgagagc agcccagttt     1020

gtcacaagac atcctattaa tgaatattac atcgcagatg cctccgagga ccaggtgttt     1080

gtgtgtgtca gccacagtaa caaccgcacc aatttataca tctcagaggc agaggggctg     1140

aagttctccc tgtccttgga gaacgtgctc tattacagcc caggaggggc cggcagtgac     1200

accttggtga ggtattttgc aaatgaacca tttgctgact tccaccgagt ggaaggattg     1260

caaggagtct acattgctac tctgattaat ggttctatga atgaggagaa catgagatcg     1320

gtcatcacct ttgacaaagg gggaacctgg gagtttcttc aggctccagc cttcacggga     1380

tatggagaga aaatcaattg tgagctttcc cagggctgtt cccttcatct ggctcagcgc     1440

ctcagtcagc tcctcaacct ccagctccgg agaatgccca tcctgtccaa ggagtcggct     1500

ccaggcctca tcatcgccac tggctcagtg ggaaagaact tggctagcaa gacaaacgtg     1560

tacatctcta gcagtgctgg agccaggtgg cgagaggcac ttcctggacc tcactactac     1620

acatggggag accacggcgg aatcatcacg gctattgccc agggcatgga aaccaacgag     1680

ctaaaataca gtaccaatga aggggagacc tggaaaacat tcatcttctc tgagaagcca     1740

gtgtttgtgt atggcctcct cacagaacct ggggagaaga gcactgtctt caccatcttt     1800

ggctcgaaca aagagaatgt ccacagctgg ctgatcctcc aggtcaatgc cacggatgcc     1860

ttgggagttc cctgcacaga gaatgactac aagctgtggt caccatctga tgagcggggg     1920

aatgagtgtt tgctgggaca caagactgtt ttcaaacggc ggacccccca tgccacatgc     1980

ttcaatggag aggactttga caggccggtg gtcgtgtcca actgctcctg cacccgggag     2040

gactatgagt gtgacttcgg tttcaagatg agtgaagatt tgtcattaga ggtttgtgtt     2100

ccagatccgg aattttctgg aaagtcatac tcccctcctg tgccttgccc tgtgggttct     2160

acttacagga gaacgagagg ctaccggaag atttctgggg acacttgtag cggaggagat     2220

gttgaagcgc gactggaagg agagctggtc ccctgtcccc tggcagaaga gaacgagttc     2280

attctgtatg ctgtgaggaa atccatctac cgctatgacc tggcctcggg agccaccgag     2340

cagttgcctc tcaccgggct acgggcagca gtggccctgg actttgacta tgagcacaac     2400

tgtttgtatt ggtccgacct ggccttggac gtcatccagc gcctctgttt gaatggaagc     2460

acagggcaag aggtgatcat caattctggc ctggagacag tagaagcttt ggcttttgaa     2520

cccctcagcc agctgcttta ctgggtagat gcaggcttca aaaagattga ggtagctaat     2580

ccagatggcg acttccgact cacaatcgtc aattcctctg tgcttgatcg tcccagggct     2640

ctggtcctcg tgccccaaga gggggtgatg ttctggacag actggggaga cctgaagcct     2700

gggatttatc ggagcaatat ggatggttct gctgcctatc acctggtgtc tgaggatgtg     2760

aagtggccca atggcatctc tgtggacgac cagtggattt actggacgga tgcctacctg     2820

gagtgcatag agcggatcac gttcagtggc cagcagcgct ctgtcattct ggacaacctc     2880

ccgcacccct atgccattgc tgtctttaag aatgaaatct actgggatga ctggtcacag     2940

ctcagcatat tccgagcttc caaatacagt gggtcccaga tggagattct ggcaaaccag     3000

ctcacggggc tcatggacat gaagattttc tacaagggga agaacactgg aagcaatgcc     3060

tgtgtgccca ggccatgcag cctgctgtgc ctgcccaagg ccaacaacag tagaagctgc     3120

aggtgtccag aggatgtgtc cagcagtgtg cttccatcag gggacctgat gtgtgactgc     3180

cctcagggct atcagctcaa gaacaatacc tgtgtcaaac aagagaacac ctgtcttcgc     3240

aaccagtatc gctgcagcaa cgggaactgt atcaacagca tttggtggtg tgactttgac     3300

aacgactgtg gagacatgag cgatgagaga aactgcccta ccaccatctg tgacctggac     3360

acccagtttc gttgccagga gtctgggact tgtatcccac tgtcctataa atgtgacctt     3420

gaggatgact gtggagacaa cagtgatgaa agtcattgtg aaatgcacca gtgccggagt     3480

gacgagtaca actgcagttc cggcatgtgc atccgctcct cctgggtatg tgacggggac     3540

aacgactgca gggactggtc tgatgaagcc aactgtaccg ccatctatca cacctgtgag     3600

gcctccaact tccagtgccg aaacgggcac tgcatccccc agcggtgggc gtgtgacggg     3660

gatacggact gccaggatgg ttccgatgag gatccagtca actgtgagaa gaagtgcaat     3720

ggattccgct gcccaaacgg cacttgcatc ccatccagca aacattgtga tggtctgcgt     3780

gattgctctg atggctccga tgaacagcac tgcgagcccc tctgtacgca cttcatggac     3840

tttgtgtgta agaaccgcca gcagtgcctg ttccactcca tggtctgtga cggaatcatc     3900

cagtgccgcg acgggtccga tgaggatgcg gcgtttgcag gatgctccca agatcctgag     3960

ttccacaagg tatgtgatga gttcggtttc cagtgtcaga atggagtgtg catcagtttg     4020

atttggaagt gcgacgggat ggatgattgc ggcgattatt ctgatgaagc caactgcgaa     4080

aaccccacag aagccccaaa ctgctcccgc tacttccagt ttcggtgtga gaatggccac     4140

tgcatcccca acagatggaa atgtgacagg gagaacgact gtggggactg gtctgatgag     4200

aaggattgtg gagattcaca tattcttccc ttctcgactc ctgggccctc cacgtgtctg     4260

cccaattact accgctgcag cagtgggacc tgcgtgatgg acacctgggt gtgcgacggg     4320

taccgagatt gtgcagatgg ctctgacgag gaagcctgcc ccttgcttgc aaacgtcact     4380

gctgcctcca ctcccaccca acttgggcga tgtgaccgat ttgagttcga atgccaccaa     4440

ccgaagacgt gtattcccaa ctggaagcgc tgtgacggcc accaagattg ccaggatggc     4500

cgggacgagg ccaattgccc cacacacagc accttgactt gcatgagcag ggagttccag     4560

tgcgaggacg gggaggcctg cattgtgctc tcggagcgct gcgacggctt cctggactgc     4620

tcggacgaga gcgatgaaaa ggcctgcagt gatgagttga ctgtgtacaa agtacagaat     4680

cttcagtgga cagctgactt ctctggggat gtgactttga cctggatgag gcccaaaaaa     4740

atgccctctg cttcttgtgt atataatgtc tactacaggg tggttggaga gagcatatgg     4800

aagactctgg agacccacag caataagaca aacactgtat taaaagtctt gaaaccagat     4860

accacgtatc aggttaaagt acaggttcag tgtctcagca aggcacacaa caccaatgac     4920

tttgtgaccc tgaggacccc agagggattg ccagatgccc ctcgaaatct ccagctgtca     4980

ctccccaggg aagcagaagg tgtgattgta ggccactggg ctcctcccat ccacacccat     5040

ggcctcatcc gtgagtacat tgtagaatac agcaggagtg gttccaagat gtgggcctcc     5100

cagagggctg ctagtaactt tacagaaatc aagaacttat tggtcaacac tctatacacc     5160

gtcagagtgg ctgcggtgac tagtcgtgga ataggaaact ggagcgattc taaatccatt     5220

accaccataa aaggaaaagt gatcccacca ccagatatcc acattgacag ctatggtgaa     5280

aattatctaa gcttcaccct gaccatggag agtgatatca aggtgaatgg ctatgtggtg     5340

aaccttttct gggcatttga cacccacaag caagagagga gaactttgaa cttccgagga     5400

agcatattgt cacacaaagt tggcaatctg acagctcata catcctatga gatttctgcc     5460

tgggccaaga ctgacttggg ggatagccct ctggcatttg agcatgttat gaccagaggg     5520

gttcgcccac ctgcacctag cctcaaggcc aaagccatca accagactgc agtggaatgt     5580

acctggaccg gcccccggaa tgtggtttat ggtattttct atgccacgtc ctttcttgac     5640

ctctatcgca acccgaagag cttgactact tcactccaca acaagacggt cattgtcagt     5700

aaggatgagc agtatttgtt tctggtccgt gtagtggtac cctaccaggg gccatcctct     5760

gactacgttg tagtgaagat gatcccggac agcaggcttc caccccgtca cctgcatgtg     5820

gttcatacgg gcaaaacctc cgtggtcatc aagtgggaat caccgtatga ctctcctgac     5880

caggacttgt tgtatgcagt tgcagtcaaa gatctcataa gaaagactga caggagctac     5940

aaagtaaaat cccgtaacag cactgtggaa tacaccctta acaagttgga gcctggcggg     6000

aaataccaca tcattgtcca actggggaac atgagcaaag attccagcat aaaaattacc     6060

acagtttcat tatcagcacc tgatgcctta aaaatcataa cagaaaatga tcatgttctt     6120

ctgttttgga aaagcctggc tttaaaggaa aagcatttta atgaaagcag gggctatgag     6180

atacacatgt ttgatagtgc catgaatatc acagcttacc ttgggaatac tactgacaat     6240

ttctttaaaa tttccaacct gaagatgggt cataattaca cgttcaccgt ccaagcaaga     6300

tgcctttttg gcaaccagat ctgtggggag cctgccatcc tgctgtacga tgagctgggg     6360

tctggtgcag atgcatctgc aacgcaggct gccagatcta cggatgttgc tgctgtggtg     6420

gtgcccatct tattcctgat actgctgagc ctgggggtgg ggtttgccat cctgtacacg     6480

aagcaccgga ggctgcagag cagcttcacc gccttcgcca acagccacta cagctccagg     6540

ctggggtccg caatcttctc ctctggggat gacctggggg aagatgatga agatgcccct     6600

atgataactg gattttcaga tgacgtcccc atggtgatag cctga                     6645


<210>  812
<211>  2214
<212>  PRT
<213>  Homo sapiens

<400>  812

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Val Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  813
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  813
atggaccgat ctaaagaaaa ctgcatttca ggacctgtta aggctacagc tccagttgga       60

ggtccaaaac gtgttctcgt gactcagcaa tttccttgtc agaatccatt acctgtaaat      120

agtggccagg ctcagcgggt cttgtgtcct tcaaattctt cccagcgcat tcctttgcaa      180

gcacaaaagc ttgtctccag tcacaagccg gttcagaatc agaagcagaa gcaattgcag      240

gcaaccagtg tacctcatcc tgtctccagg ccactgaata acacccaaaa gagcaagcag      300

cccctgccat cggcacctga aaataatcct gaggaggaac tggcatcaaa acagaaaaat      360

gaagaatcaa aaaagaggca gtgggctttg gaagactttg aaattggtcg ccctctgggt      420

aaaggaaagt ttggtaatgt ttatttggca agagaaaagc aaagcaagtt tattctggct      480

cttaaagtgt tatttaaagc tcagctggag aaagccggag tggagcatca gctcagaaga      540

gaagtagaaa tacagtccca ccttcggcat cctaatattc ttagactgta tggttatttc      600

catgatgcta ccagagtcta cctaattctg gaatatgcac cacttggaac agtttataga      660

gaacttcaga aactttcaaa gtttgatgag cagagaactg ctacttatat aacagaattg      720

gcaaatgccc tgtcttactg tcattcgaag agagttattc atagagacat taagccagag      780

aacttacttc ttggatcagc tggagagctt aaaattgcag attttgggtg gtcagtacat      840

gctccatctt ccaggaggac cactctctgt ggcaccctgg actacctgcc ccctgaaatg      900

attgaaggtc ggatgcatga tgagaaggtg gatctctgga gccttggagt tctttgctat      960

gaatttttag ttgggaagcc tccttttgag gcaaacacat accaagagac ctacaaaaga     1020

atatcacggg ttgaattcac attccctgac tttgtaacag agggagccag ggacctcatt     1080

tcaagactgt tgaagcataa tcccagccag aggccaatgc tcagagaagt acttgaacac     1140

ccctggatca cagcaaattc atcaaaacca tcaaattgcc aaaacaaaga atcagctagc     1200

aaacagtctt ag                                                         1212


<210>  814
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  814

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  815
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  815
atggcttctt ctgatatcca ggtgaaagaa ctggagaagc gtgcctcagg ccaggctttt       60

gagctgattc tcagccctcg gtcaaaagaa tctgttccag aattccccct ttcccctcca      120

aagaagaagg atctttccct ggaggaaatt cagaagaaat tagaagctgc agaagaaaga      180

cgcaagtccc atgaagctga ggtcttgaag cagctggctg agaaacgaga gcacgagaaa      240

gaagtgcttc agaaggcaat agaagagaac aacaacttca gtaaaatggc agaagagaaa      300

ctgacccaca aaatggaagc taataaagag aaccgagagg cacaaatggc tgccaaactg      360

gaacgtttgc gagagaagga taagcacatt gaagaagtgc ggaagaacaa agaatccaaa      420

gaccctgctg acgagactga agctgactaa                                       450


<210>  816
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  816

Met Ala Ser Ser Asp Ile Gln Val Lys Glu Leu Glu Lys Arg Ala Ser 
1               5                   10                  15      


Gly Gln Ala Phe Glu Leu Ile Leu Ser Pro Arg Ser Lys Glu Ser Val 
            20                  25                  30          


Pro Glu Phe Pro Leu Ser Pro Pro Lys Lys Lys Asp Leu Ser Leu Glu 
        35                  40                  45              


Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Ser His 
    50                  55                  60                  


Glu Ala Glu Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His Glu Lys 
65                  70                  75                  80  


Glu Val Leu Gln Lys Ala Ile Glu Glu Asn Asn Asn Phe Ser Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Leu Thr His Lys Met Glu Ala Asn Lys Glu Asn Arg 
            100                 105                 110         


Glu Ala Gln Met Ala Ala Lys Leu Glu Arg Leu Arg Glu Lys Asp Lys 
        115                 120                 125             


His Ile Glu Glu Val Arg Lys Asn Lys Glu Ser Lys Asp Pro Ala Asp 
    130                 135                 140                 


Glu Thr Glu Ala Asp 
145                 


<210>  817
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  817
atgtcatacg gtcccttaga catgtaccgg aacccggggc cctcggggcc ccagctccgg       60

gacttcagca gcatcatcca gacgtgcagc ggcaacatcc agcggatcag ccaagccact      120

gctcagataa agaatttgat gagccagcta ggaactaagc aggactcaag caagctacag      180

gaaaatctgc aacagttaca acactccaca aatcagctcg ccaaggaaac aaatgaattg      240

ctgaaagaat tagggtcctt gccccttccc ttatctactt cagaacagcg ccagcagaga      300

cttcagaagg aacgcctcat gaatgacttc tctgcagcct taaacaattt ccaggctgtg      360

cagagaaggg tatctgaaaa ggaaaaggag agtattgcca gagcaagagc tggatctcgt      420

ctttctgcag aagagaggca aagagaggag cagctggtct catttgacag ccatgaggag      480

tggaaccaga tgcagagcca ggaggatgag gtggccatca ctgagcagga tttggaactt      540

attaaagaaa gagaaacggc aattcggcag ctggaggctg acattttgga tgtcaatcag      600

atatttaaag atttggccat gatgatccat gaccagggtg atctgattga tagcatagaa      660

gccaatgtgg aaagctcaga ggtgcacgtc gaaagagcca ctgaacagtt acagcgagct      720

gcttactatc agaaaaaatc tcgcaagaag atgtgtatcc tggtgcttgt cctgtcagtg      780

attattctaa tcttgggact tattatctgg ctagtttata aaacgaagtg a               831


<210>  818
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  818

Met Ser Tyr Gly Pro Leu Asp Met Tyr Arg Asn Pro Gly Pro Ser Gly 
1               5                   10                  15      


Pro Gln Leu Arg Asp Phe Ser Ser Ile Ile Gln Thr Cys Ser Gly Asn 
            20                  25                  30          


Ile Gln Arg Ile Ser Gln Ala Thr Ala Gln Ile Lys Asn Leu Met Ser 
        35                  40                  45              


Gln Leu Gly Thr Lys Gln Asp Ser Ser Lys Leu Gln Glu Asn Leu Gln 
    50                  55                  60                  


Gln Leu Gln His Ser Thr Asn Gln Leu Ala Lys Glu Thr Asn Glu Leu 
65                  70                  75                  80  


Leu Lys Glu Leu Gly Ser Leu Pro Leu Pro Leu Ser Thr Ser Glu Gln 
                85                  90                  95      


Arg Gln Gln Arg Leu Gln Lys Glu Arg Leu Met Asn Asp Phe Ser Ala 
            100                 105                 110         


Ala Leu Asn Asn Phe Gln Ala Val Gln Arg Arg Val Ser Glu Lys Glu 
        115                 120                 125             


Lys Glu Ser Ile Ala Arg Ala Arg Ala Gly Ser Arg Leu Ser Ala Glu 
    130                 135                 140                 


Glu Arg Gln Arg Glu Glu Gln Leu Val Ser Phe Asp Ser His Glu Glu 
145                 150                 155                 160 


Trp Asn Gln Met Gln Ser Gln Glu Asp Glu Val Ala Ile Thr Glu Gln 
                165                 170                 175     


Asp Leu Glu Leu Ile Lys Glu Arg Glu Thr Ala Ile Arg Gln Leu Glu 
            180                 185                 190         


Ala Asp Ile Leu Asp Val Asn Gln Ile Phe Lys Asp Leu Ala Met Met 
        195                 200                 205             


Ile His Asp Gln Gly Asp Leu Ile Asp Ser Ile Glu Ala Asn Val Glu 
    210                 215                 220                 


Ser Ser Glu Val His Val Glu Arg Ala Thr Glu Gln Leu Gln Arg Ala 
225                 230                 235                 240 


Ala Tyr Tyr Gln Lys Lys Ser Arg Lys Lys Met Cys Ile Leu Val Leu 
                245                 250                 255     


Val Leu Ser Val Ile Ile Leu Ile Leu Gly Leu Ile Ile Trp Leu Val 
            260                 265                 270         


Tyr Lys Thr Lys 
        275     


<210>  819
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  819
atggaggacc tggatgccct gctctctgac ctggagacta ccacctcgca catgccaagg       60

tcaggggctc ccaaagagcg ccctgcggag cctctcaccc ctcccccatc ctatggccac      120

cagccacaga cagggtctgg ggagtcttca ggagcctcgg gggacaagga ccacctgtac      180

agcacggtat gcaagcctcg gtccccaaag cctgcagccc cggcggcccc tccattctcc      240

tcttccagcg gtgtcttggg taccgggctc tgtgagctag atcggttgct tcaggaactt      300

aatgccactc agttcaacat cacagatgaa atcatgtctc agttcccatc tagcaaggtg      360

gcttcaggag agcagaagga ggaccagtct gaagataaga aaagacccag cctcccttcc      420

agcccgtctc ctggcctccc aaaggcttct gccacctcag ccactctgga gctggataga      480

ctgatggcct cactctctga cttccgcgtt caaaaccatc ttccagcctc tgggccaact      540

cagccaccgg tggtgagctc cacaaatgag ggctccccat ccccaccaga gccgactggc      600

aagggcagcc tagacaccat gctggggctg ctgcagtccg acctcagccg ccggggtgtt      660

cccacccagg ccaaaggcct ctgtggctcc tgcaataaac ctattgctgg gcaagtggtg      720

acggctctgg gccgcgcctg gcaccccgag cacttcgttt gcggaggctg ttccaccgcc      780

ctgggaggca gcagcttctt cgagaaggat ggagccccct tctgccccga gtgctacttt      840

gagcgcttct cgccaagatg tggcttctgc aaccagccca tccgacacaa gatggtgacc      900

gccttgggca ctcactggca cccagagcat ttctgctgcg tcagttgcgg ggagcccttc      960

ggagatgagg gtttccacga gcgcgagggc cgcccctact gccgccggga cttcctgcag     1020

ctgttcgccc cgcgctgcca gggctgccag ggccccatcc tggataacta catctcggcg     1080

ctcagcgcgc tctggcaccc ggactgtttc gtctgcaggg aatgcttcgc gcccttctcg     1140

ggaggcagct ttttcgagca cgagggccgc ccgttgtgcg agaaccactt ccacgcacga     1200

cgcggctcgc tgtgcgccac gtgtggcctc cctgtgaccg gccgctgcgt gtcggccctg     1260

ggtcgccgct tccacccgga ccacttcaca tgcaccttct gcctgcgccc gctcaccaag     1320

gggtccttcc aggagcgcgc cggcaagccc tactgccagc cctgcttcct gaagctcttc     1380

ggctga                                                                1386


<210>  820
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  820

Met Glu Asp Leu Asp Ala Leu Leu Ser Asp Leu Glu Thr Thr Thr Ser 
1               5                   10                  15      


His Met Pro Arg Ser Gly Ala Pro Lys Glu Arg Pro Ala Glu Pro Leu 
            20                  25                  30          


Thr Pro Pro Pro Ser Tyr Gly His Gln Pro Gln Thr Gly Ser Gly Glu 
        35                  40                  45              


Ser Ser Gly Ala Ser Gly Asp Lys Asp His Leu Tyr Ser Thr Val Cys 
    50                  55                  60                  


Lys Pro Arg Ser Pro Lys Pro Ala Ala Pro Ala Ala Pro Pro Phe Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Val Leu Gly Thr Gly Leu Cys Glu Leu Asp Arg Leu 
                85                  90                  95      


Leu Gln Glu Leu Asn Ala Thr Gln Phe Asn Ile Thr Asp Glu Ile Met 
            100                 105                 110         


Ser Gln Phe Pro Ser Ser Lys Val Ala Ser Gly Glu Gln Lys Glu Asp 
        115                 120                 125             


Gln Ser Glu Asp Lys Lys Arg Pro Ser Leu Pro Ser Ser Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Lys Ala Ser Ala Thr Ser Ala Thr Leu Glu Leu Asp Arg 
145                 150                 155                 160 


Leu Met Ala Ser Leu Ser Asp Phe Arg Val Gln Asn His Leu Pro Ala 
                165                 170                 175     


Ser Gly Pro Thr Gln Pro Pro Val Val Ser Ser Thr Asn Glu Gly Ser 
            180                 185                 190         


Pro Ser Pro Pro Glu Pro Thr Gly Lys Gly Ser Leu Asp Thr Met Leu 
        195                 200                 205             


Gly Leu Leu Gln Ser Asp Leu Ser Arg Arg Gly Val Pro Thr Gln Ala 
    210                 215                 220                 


Lys Gly Leu Cys Gly Ser Cys Asn Lys Pro Ile Ala Gly Gln Val Val 
225                 230                 235                 240 


Thr Ala Leu Gly Arg Ala Trp His Pro Glu His Phe Val Cys Gly Gly 
                245                 250                 255     


Cys Ser Thr Ala Leu Gly Gly Ser Ser Phe Phe Glu Lys Asp Gly Ala 
            260                 265                 270         


Pro Phe Cys Pro Glu Cys Tyr Phe Glu Arg Phe Ser Pro Arg Cys Gly 
        275                 280                 285             


Phe Cys Asn Gln Pro Ile Arg His Lys Met Val Thr Ala Leu Gly Thr 
    290                 295                 300                 


His Trp His Pro Glu His Phe Cys Cys Val Ser Cys Gly Glu Pro Phe 
305                 310                 315                 320 


Gly Asp Glu Gly Phe His Glu Arg Glu Gly Arg Pro Tyr Cys Arg Arg 
                325                 330                 335     


Asp Phe Leu Gln Leu Phe Ala Pro Arg Cys Gln Gly Cys Gln Gly Pro 
            340                 345                 350         


Ile Leu Asp Asn Tyr Ile Ser Ala Leu Ser Ala Leu Trp His Pro Asp 
        355                 360                 365             


Cys Phe Val Cys Arg Glu Cys Phe Ala Pro Phe Ser Gly Gly Ser Phe 
    370                 375                 380                 


Phe Glu His Glu Gly Arg Pro Leu Cys Glu Asn His Phe His Ala Arg 
385                 390                 395                 400 


Arg Gly Ser Leu Cys Ala Thr Cys Gly Leu Pro Val Thr Gly Arg Cys 
                405                 410                 415     


Val Ser Ala Leu Gly Arg Arg Phe His Pro Asp His Phe Thr Cys Thr 
            420                 425                 430         


Phe Cys Leu Arg Pro Leu Thr Lys Gly Ser Phe Gln Glu Arg Ala Gly 
        435                 440                 445             


Lys Pro Tyr Cys Gln Pro Cys Phe Leu Lys Leu Phe Gly 
    450                 455                 460     


<210>  821
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  821
atgactccca acagtatgac agaaaatggc cttacagcct gggacaaacc gaagcactgt       60

ccagaccgag aacacgactg gaagctagta ggaatgtctg aagcctgcct acataggaag      120

agccattcag agaggcgcag cacgttgaaa aatgaacagt cgtcgccaca tctcatccag      180

accacttgga ctagctcaat attccatctg gaccatgatg atgtgaacga ccagagtgtc      240

tcaagtgccc agaccttcca aacggaggag aagaaatgta aagggtacat ccccagttac      300

ttagacaagg acgagctctg tgtagtgtgt ggtgacaaag ccaccgggta tcactaccgc      360

tgtatcacgt gtgaaggctg caagggtttc tttagaagaa ccattcagaa aaatctccat      420

ccatcctatt cctgtaaata tgaaggaaaa tgtgtcatag acaaagtcac gcgaaatcag      480

tgccaggaat gtcgctttaa gaaatgcatc tatgttggca tggcaacaga tttggtgctg      540

gatgacagca agaggctggc caagaggaag ctgatagagg agaaccggga gaaaagacgg      600

cgggaagagc tgcagaagtc catcgggcac aagccagagc ccacagacga ggaatgggag      660

ctcatcaaaa ctgtcaccga agcccatgtg gcgaccaacg cccaaggcag ccactggaag      720

caaaaacgga aattcctgcc agaagacatt ggacaagcac caatagtcaa tgccccagaa      780

ggtggaaagg ttgacttgga agccttcagc cattttacaa aaatcatcac accagcaatt      840

accagagtgg tggattttgc caaaaagttg cctatgtttt gtgagctgcc atgtgaagac      900

cagatcatcc tcctcaaagg ctgctgcatg gagatcatgt cccttcgcgc tgctgtgcgc      960

tatgacccag aaagtgagac tttaaccttg aatggggaaa tggcagtgac acggggccag     1020

ctgaaaaatg ggggtcttgg ggtggtgtca gacgccatct ttgacctggg catgtctctg     1080

tcttctttca acctggatga cactgaagta gccctccttc aggccgtcct gctgatgtct     1140

tcagatcgcc cggggcttgc ctgtgttgag agaatagaaa agtaccaaga tagtttcctg     1200

ctggcctttg aacactatat caattaccga aaacaccacg tgacacactt ttggccaaaa     1260

ctcctgatga aggtgacaga tctgcggatg ataggagcct gccatgccag ccgcttcctg     1320

cacatgaagg tggaatgccc cacagaactc ttcccccctt tgttcttgga agtgttcgag     1380

gattag                                                                1386


<210>  822
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  822

Met Thr Pro Asn Ser Met Thr Glu Asn Gly Leu Thr Ala Trp Asp Lys 
1               5                   10                  15      


Pro Lys His Cys Pro Asp Arg Glu His Asp Trp Lys Leu Val Gly Met 
            20                  25                  30          


Ser Glu Ala Cys Leu His Arg Lys Ser His Ser Glu Arg Arg Ser Thr 
        35                  40                  45              


Leu Lys Asn Glu Gln Ser Ser Pro His Leu Ile Gln Thr Thr Trp Thr 
    50                  55                  60                  


Ser Ser Ile Phe His Leu Asp His Asp Asp Val Asn Asp Gln Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gln Thr Phe Gln Thr Glu Glu Lys Lys Cys Lys Gly Tyr 
                85                  90                  95      


Ile Pro Ser Tyr Leu Asp Lys Asp Glu Leu Cys Val Val Cys Gly Asp 
            100                 105                 110         


Lys Ala Thr Gly Tyr His Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys 
        115                 120                 125             


Gly Phe Phe Arg Arg Thr Ile Gln Lys Asn Leu His Pro Ser Tyr Ser 
    130                 135                 140                 


Cys Lys Tyr Glu Gly Lys Cys Val Ile Asp Lys Val Thr Arg Asn Gln 
145                 150                 155                 160 


Cys Gln Glu Cys Arg Phe Lys Lys Cys Ile Tyr Val Gly Met Ala Thr 
                165                 170                 175     


Asp Leu Val Leu Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile 
            180                 185                 190         


Glu Glu Asn Arg Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile 
        195                 200                 205             


Gly His Lys Pro Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr 
    210                 215                 220                 


Val Thr Glu Ala His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys 
225                 230                 235                 240 


Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val 
                245                 250                 255     


Asn Ala Pro Glu Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe 
            260                 265                 270         


Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys 
        275                 280                 285             


Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu 
    290                 295                 300                 


Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg 
305                 310                 315                 320 


Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val 
                325                 330                 335     


Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala 
            340                 345                 350         


Ile Phe Asp Leu Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr 
        355                 360                 365             


Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro 
    370                 375                 380                 


Gly Leu Ala Cys Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu 
385                 390                 395                 400 


Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His His Val Thr His 
                405                 410                 415     


Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly 
            420                 425                 430         


Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr 
        435                 440                 445             


Glu Leu Phe Pro Pro Leu Phe Leu Glu Val Phe Glu Asp 
    450                 455                 460     


<210>  823
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  823
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccctga                                636


<210>  824
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  824

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  825
<211>  2085
<212>  DNA
<213>  Homo sapiens

<400>  825
atgccggagt tcctggaaga cccctcggtc ctgacaaaag acaagttgaa gagtgagttg       60

gtcgccaaca atgtgacgct gccggccggg gagcagcgca aagacgtgta cgtccagctc      120

tacctgcagc acctcacggc tcgcaaccgg ccgccgctcc ccgccggcac caacagcaag      180

gggcccccgg acttctccag tgacgaagag cgcgagccca ccccggtcct cggctctggg      240

gccgccgccg cgggccggag ccgagcagcc gtcggcagga aagccacaaa aaaaactgat      300

aaacccagac aagaagataa agatgatcta gatgtaacag agctcactaa tgaagatctt      360

ttggatcagc ttgtgaaata cggagtgaat cctggtccta ttgtgggaac aaccaggaag      420

ctatatgaga aaaagctttt gaaactgagg gaacaaggaa cagaatcaag atcttctact      480

cctctgccaa caatttcttc ttcagcagaa aatacaaggc agaatggaag taatgattct      540

gacagataca gtgacaatga agaaggaaag aagaaagaac acaagaaagt gaagtccact      600

agggatattg ttcctttttc tgaacttgga actactccct ctggtggtgg attttttcag      660

ggtatttctt ttcctgaaat ctccacccgt cctcctttgg gcagtaccga actacaggca      720

gctaagaaag tacatacttc taagggagac ctacctaggg agcctcttgt tgccacaaac      780

ttgcctggca ggggacagtt gcagaagtta gcctctgaaa ggaatttgtt tatttcatgc      840

aagtctagcc atgataggtg tttagagaaa agttcttcgt catcttctca gcctgaacac      900

agtgccatgt tggtctctac tgcagcttct ccttcactga ttaaagaaac caccactggt      960

tactataaag acatagtaga aaatatttgc ggtagagaga aaagtggaat tcaaccatta     1020

tgtcctgaga ggtcccatat ttcagatcaa tcgcctctct ccagtaaaag gaaagcacta     1080

gaagagtctg agagctcaca actaatttct ccgccacttg cccaggcaat cagagattat     1140

gtcaattctc tgttggtcca gggtggggta ggtagtttgc ctggaacttc taactctatg     1200

cccccactgg atgtagaaaa catacagaag agaattgatc agtctaagtt tcaagaaact     1260

gaattcctgt ctcctccaag aaaagtccct agactgagtg agaagtcagt ggaggaaagg     1320

gattcaggtt cctttgtggc atttcagaac atacctggat ccgaactgat gtcttctttt     1380

gccaaaactg ttgtctctca ttcactcact accttaggtc tagaagtggc taagcaatca     1440

cagcatgata aaatagatgc ctcagaacta tcttttccct tccatgaatc tattttaaaa     1500

gtaattgaag aagaatggca gcaagttgac aggcagctgc cttcactggc atgcaaatat     1560

ccagtttctt ccagggaggc aacacagata ttatcagttc caaaagtaga tgatgaaatc     1620

ctagggttta tttctgaagc cactccacta ggaggtattc aagcagcctc cactgagtct     1680

tgcaatcagc agttggactt agcactctgt agagcatatg aagctgcagc atcagcattg     1740

cagattgcaa ctcacactgc ctttgtagct aaggctatgc aggcagacat tagtcaagct     1800

gcacagattc ttagctcaga tcctagtcgt acccaccaag cgcttgggat tctgagcaaa     1860

acatatgatg cagcctcata tatttgtgaa gctgcatttg atgaagtgaa gatggctgcc     1920

cataccatgg gaaatgccac tgtaggtcgt cgatacctct ggctgaagga ttgcaaaatt     1980

aatttagctt ctaagaataa gctggcttcc actcccttta aaggtggaac attatttgga     2040

ggagaagtat gcaaagtaat taaaaagcgt ggaaataaac actag                     2085


<210>  826
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  826

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Gly Lys Lys Lys 
            180                 185                 190         


Glu His Lys Lys Val Lys Ser Thr Arg Asp Ile Val Pro Phe Ser Glu 
        195                 200                 205             


Leu Gly Thr Thr Pro Ser Gly Gly Gly Phe Phe Gln Gly Ile Ser Phe 
    210                 215                 220                 


Pro Glu Ile Ser Thr Arg Pro Pro Leu Gly Ser Thr Glu Leu Gln Ala 
225                 230                 235                 240 


Ala Lys Lys Val His Thr Ser Lys Gly Asp Leu Pro Arg Glu Pro Leu 
                245                 250                 255     


Val Ala Thr Asn Leu Pro Gly Arg Gly Gln Leu Gln Lys Leu Ala Ser 
            260                 265                 270         


Glu Arg Asn Leu Phe Ile Ser Cys Lys Ser Ser His Asp Arg Cys Leu 
        275                 280                 285             


Glu Lys Ser Ser Ser Ser Ser Ser Gln Pro Glu His Ser Ala Met Leu 
    290                 295                 300                 


Val Ser Thr Ala Ala Ser Pro Ser Leu Ile Lys Glu Thr Thr Thr Gly 
305                 310                 315                 320 


Tyr Tyr Lys Asp Ile Val Glu Asn Ile Cys Gly Arg Glu Lys Ser Gly 
                325                 330                 335     


Ile Gln Pro Leu Cys Pro Glu Arg Ser His Ile Ser Asp Gln Ser Pro 
            340                 345                 350         


Leu Ser Ser Lys Arg Lys Ala Leu Glu Glu Ser Glu Ser Ser Gln Leu 
        355                 360                 365             


Ile Ser Pro Pro Leu Ala Gln Ala Ile Arg Asp Tyr Val Asn Ser Leu 
    370                 375                 380                 


Leu Val Gln Gly Gly Val Gly Ser Leu Pro Gly Thr Ser Asn Ser Met 
385                 390                 395                 400 


Pro Pro Leu Asp Val Glu Asn Ile Gln Lys Arg Ile Asp Gln Ser Lys 
                405                 410                 415     


Phe Gln Glu Thr Glu Phe Leu Ser Pro Pro Arg Lys Val Pro Arg Leu 
            420                 425                 430         


Ser Glu Lys Ser Val Glu Glu Arg Asp Ser Gly Ser Phe Val Ala Phe 
        435                 440                 445             


Gln Asn Ile Pro Gly Ser Glu Leu Met Ser Ser Phe Ala Lys Thr Val 
    450                 455                 460                 


Val Ser His Ser Leu Thr Thr Leu Gly Leu Glu Val Ala Lys Gln Ser 
465                 470                 475                 480 


Gln His Asp Lys Ile Asp Ala Ser Glu Leu Ser Phe Pro Phe His Glu 
                485                 490                 495     


Ser Ile Leu Lys Val Ile Glu Glu Glu Trp Gln Gln Val Asp Arg Gln 
            500                 505                 510         


Leu Pro Ser Leu Ala Cys Lys Tyr Pro Val Ser Ser Arg Glu Ala Thr 
        515                 520                 525             


Gln Ile Leu Ser Val Pro Lys Val Asp Asp Glu Ile Leu Gly Phe Ile 
    530                 535                 540                 


Ser Glu Ala Thr Pro Leu Gly Gly Ile Gln Ala Ala Ser Thr Glu Ser 
545                 550                 555                 560 


Cys Asn Gln Gln Leu Asp Leu Ala Leu Cys Arg Ala Tyr Glu Ala Ala 
                565                 570                 575     


Ala Ser Ala Leu Gln Ile Ala Thr His Thr Ala Phe Val Ala Lys Ala 
            580                 585                 590         


Met Gln Ala Asp Ile Ser Gln Ala Ala Gln Ile Leu Ser Ser Asp Pro 
        595                 600                 605             


Ser Arg Thr His Gln Ala Leu Gly Ile Leu Ser Lys Thr Tyr Asp Ala 
    610                 615                 620                 


Ala Ser Tyr Ile Cys Glu Ala Ala Phe Asp Glu Val Lys Met Ala Ala 
625                 630                 635                 640 


His Thr Met Gly Asn Ala Thr Val Gly Arg Arg Tyr Leu Trp Leu Lys 
                645                 650                 655     


Asp Cys Lys Ile Asn Leu Ala Ser Lys Asn Lys Leu Ala Ser Thr Pro 
            660                 665                 670         


Phe Lys Gly Gly Thr Leu Phe Gly Gly Glu Val Cys Lys Val Ile Lys 
        675                 680                 685             


Lys Arg Gly Asn Lys His 
    690                 


<210>  827
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  827
atggctttaa aagtgctact agaacaagag aaaacgtttt tcactctttt agtattacta       60

ggctatttgt catgtaaagt gacttgtgaa tcaggagact gtagacagca agaattcagg      120

gatcggtctg gaaactgtgt tccctgcaac cagtgtgggc caggcatgga gttgtctaag      180

gaatgtggct tcggctatgg ggaggatgca cagtgtgtga cgtgccggct gcacaggttc      240

aaggaggact ggggcttcca gaaatgcaag ccctgtctgg actgcgcagt ggtgaaccgc      300

tttcagaagg caaattgttc agccaccagt gatgccatct gcggggactg cttgccagga      360

ttttatagga agacgaaact tgtcggcttt caagacatgg agtgtgtgcc ttgtggagac      420

cctcctcctc cttacgaacc gcactgtgcc agcaaggtca acctcgtgaa gatcgcgtcc      480

acggcctcca gcccacggga cacggcgctg gctgccgtta tctgcagcgc tctggccacc      540

gtcctgctgg ccctgctcat cctctgtgtc atctattgta agagacagtt tatggagaag      600

aaacccagct ggtctctgcg gtcacaggac attcagtaca acggctctga gctgtcgtgt      660

tttgacagac ctcagctcca cgaatatgcc cacagagcct gctgccagtg ccgccgtgac      720

tcagtgcaga cctgcgggcc ggtgcgcttg ctcccatcca tgtgctgtga ggaggcctgc      780

agccccaacc cggcgactct tggttgtggg gtgcattctg cagccagtct tcaggcaaga      840

aacgcaggcc cagccgggga gatggtgccg actttcttcg gatccctcac gcagtccatc      900

tgtggcgagt tttcagatgc ctggcctctg atgcagaatc ccatgggtgg tgacaacatc      960

tctttttgtg actcttatcc tgaactcact ggagaagaca ttcattctct caatccagaa     1020

cttgaaagct caacgtcttt ggattcaaat agcagtcaag atttggttgg tggggctgtt     1080

ccagtccagt ctcattctga aaactttaca gcagctactg atttatctag atataacaac     1140

acactggtag aatcagcatc aactcaggat gcactaacta tgagaagcca gctagatcag     1200

gagagtggtg ctgtcatcca cccagccact cagacgtccc tccaggtaag gcagcgactg     1260

ggttccctgt ga                                                         1272


<210>  828
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  828

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Val 
                405                 410                 415     


Arg Gln Arg Leu Gly Ser Leu 
            420             


<210>  829
<211>  4596
<212>  DNA
<213>  Homo sapiens

<400>  829
atggaagtgt caccattgca gcctgtaaat gaaaatatgc aagtcaacaa aataaagaaa       60

aatgaagatg ctaagaaaag actgtctgtt gaaagaatct atcaaaagaa aacacaattg      120

gaacatattt tgctccgccc agacacctac attggttctg tggaattagt gacccagcaa      180

atgtgggttt acgatgaaga tgttggcatt aactataggg aagtcacttt tgttcctggt      240

ttgtacaaaa tctttgatga gattctagtt aatgctgcgg acaacaaaca aagggaccca      300

aaaatgtctt gtattagagt cacaattgat ccggaaaaca atttaattag tatatggaat      360

aatggaaaag gtattcctgt tgttgaacac aaagttgaaa agatgtatgt cccagctctc      420

atatttggac agctcctaac ttctagtaac tatgatgatg atgaaaagaa agtgacaggt      480

ggtcgaaatg gctatggagc caaattgtgt aacatattca gtaccaaatt tactgtggaa      540

acagccagta gagaatacaa gaaaatgttc aaacagacat ggatggataa tatgggaaga      600

gctggtgaga tggaactcaa gcccttcaat ggagaagatt atacatgtat cacctttcag      660

cctgatttgt ctaagtttaa aatgcaaagc ctggacaaag atattgttgc actaatggtc      720

agaagagcat atgatattgc tggatccacc aaagatgtca aagtctttct taatggaaat      780

aaactgccag taaaaggatt tcgtagttat gtggacatgt atttgaagga caagttggat      840

gaaactggta actccttgaa agtaatacat gaacaagtaa accacaggtg ggaagtgtgt      900

ttaactatga gtgaaaaagg ctttcagcaa attagctttg tcaacagcat tgctacatcc      960

aagggtggca gacatgttga ttatgtagct gatcagattg tgactaaact tgttgatgtt     1020

gtgaagaaga agaacaaggg tggtgttgca gtaaaagcac atcaggtgaa aaatcacatg     1080

tggatttttg taaatgcctt aattgaaaac ccaacctttg actctcagac aaaagaaaac     1140

atgactttac aacccaagag ctttggatca acatgccaat tgagtgaaaa atttatcaaa     1200

gctgccattg gctgtggtat tgtagaaagc atactaaact gggtgaagtt taaggcccaa     1260

gtccagttaa acaagaagtg ttcagctgta aaacataata gaatcaaggg aattcccaaa     1320

ctcgatgatg ccaatgatgc agggggccga aactccactg agtgtacgct tatcctgact     1380

gagggagatt cagccaaaac tttggctgtt tcaggccttg gtgtggttgg gagagacaaa     1440

tatggggttt tccctcttag aggaaaaata ctcaatgttc gagaagcttc tcataagcag     1500

atcatggaaa atgctgagat taacaatatc atcaagattg tgggtcttca gtacaagaaa     1560

aactatgaag atgaagattc attgaagacg cttcgttatg ggaagataat gattatgaca     1620

gatcaggacc aagatggttc ccacatcaaa ggcttgctga ttaattttat ccatcacaac     1680

tggccctctc ttctgcgaca tcgttttctg gaggaattta tcactcccat tgtaaaggta     1740

tctaaaaaca agcaagaaat ggcattttac agccttcctg aatttgaaga gtggaagagt     1800

tctactccaa atcataaaaa atggaaagtc aaatattaca aaggtttggg caccagcaca     1860

tcaaaggaag ctaaagaata ctttgcagat atgaaaagac atcgtatcca gttcaaatat     1920

tctggtcctg aagatgatgc tgctatcagc ctggccttta gcaaaaaaca gatagatgat     1980

cgaaaggaat ggttaactaa tttcatggag gatagaagac aacgaaagtt acttgggctt     2040

cctgaggatt acttgtatgg acaaactacc acatatctga catataatga cttcatcaac     2100

aaggaactta tcttgttctc aaattctgat aacgagagat ctatcccttc tatggtggat     2160

ggtttgaaac caggtcagag aaaggttttg tttacttgct tcaaacggaa tgacaagcga     2220

gaagtaaagg ttgcccaatt agctggatca gtggctgaaa tgtcttctta tcatcatggt     2280

gagatgtcac taatgatgac cattatcaat ttggctcaga attttgtggg tagcaataat     2340

ctaaacctct tgcagcccat tggtcagttt ggtaccaggc tacatggtgg caaggattct     2400

gctagtccac gatacatctt tacaatgctc agctctttgg ctcgattgtt atttccacca     2460

aaagatgatc acacgttgaa gtttttatat gatgacaacc agcgtgttga gcctgaatgg     2520

tacattccta ttattcccat ggtgctgata aatggtgctg aaggaatcgg tactgggtgg     2580

tcctgcaaaa tccccaactt tgatgtgcgt gaaattgtaa ataacatcag gcgtttgatg     2640

gatggagaag aacctttgcc aatgcttcca agttacaaga acttcaaggg tactattgaa     2700

gaactggctc caaatcaata tgtgattagt ggtgaagtag ctattcttaa ttctacaacc     2760

attgaaatct cagagcttcc cgtcagaaca tggacccaga catacaaaga acaagttcta     2820

gaacccatgt tgaatggcac cgagaagaca cctcctctca taacagacta tagggaatac     2880

catacagata ccactgtgaa atttgttgtg aagatgactg aagaaaaact ggcagaggca     2940

gagagagttg gactacacaa agtcttcaaa ctccaaacta gtctcacatg caactctatg     3000

gtgctttttg accacgtagg ctgtttaaag aaatatgaca cggtgttgga tattctaaga     3060

gacttttttg aactcagact taaatattat ggattaagaa aagaatggct cctaggaatg     3120

cttggtgctg aatctgctaa actgaataat caggctcgct ttatcttaga gaaaatagat     3180

ggcaaaataa tcattgaaaa taagcctaag aaagaattaa ttaaagttct gattcagagg     3240

ggatatgatt cggatcctgt gaaggcctgg aaagaagccc agcaaaaggt tccagatgaa     3300

gaagaaaatg aagagagtga caacgaaaag gaaactgaaa agagtgactc cgtaacagat     3360

tctggaccaa ccttcaacta tcttcttgat atgccccttt ggtatttaac caaggaaaag     3420

aaagatgaac tctgcaggct aagaaatgaa aaagaacaag agctggacac attaaaaaga     3480

aagagtccat cagatttgtg gaaagaagac ttggctacat ttattgaaga attggaggct     3540

gttgaagcca aggaaaaaca agatgaacaa gtcggacttc ctgggaaagg ggggaaggcc     3600

aaggggaaaa aaacacaaat ggctgaagtt ttgccttctc cgcgtggtca aagagtcatt     3660

ccacgaataa ccatagaaat gaaagcagag gcagaaaaga aaaataaaaa gaaaattaag     3720

aatgaaaata ctgaaggaag ccctcaagaa gatggtgtgg aactagaagg cctaaaacaa     3780

agattagaaa agaaacagaa aagagaacca ggtacaaaga caaagaaaca aactacattg     3840

gcatttaagc caatcaaaaa aggaaagaag agaaatccct ggtctgattc agaatcagat     3900

aggagcagtg acgaaagtaa ttttgatgtc cctccacgag aaacagagcc acggagagca     3960

gcaacaaaaa caaaattcac aatggatttg gattcagatg aagatttctc agattttgat     4020

gaaaaaactg atgatgaaga ttttgtccca tcagatgcta gtccacctaa gaccaaaact     4080

tccccaaaac ttagtaacaa agaactgaaa ccacagaaaa gtgtcgtgtc agaccttgaa     4140

gctgatgatg ttaagggcag tgtaccactg tcttcaagcc ctcctgctac acatttccca     4200

gatgaaactg aaattacaaa cccagttcct aaaaagaatg tgacagtgaa gaagacagca     4260

gcaaaaagtc agtcttccac ctccactacc ggtgccaaaa aaagggctgc cccaaaagga     4320

actaaaaggg atccagcttt gaattctggt gtctctcaaa agcctgatcc tgccaaaacc     4380

aagaatcgcc gcaaaaggaa gccatccact tctgatgatt ctgactctaa ttttgagaaa     4440

attgtttcga aagcagtcac aagcaagaaa tccaaggggg agagtgatga cttccatatg     4500

gactttgact cagctgtggc tcctcgggca aaatctgtac gggcaaagaa acctataaag     4560

tacctggaag agtcagatga agatgatctg ttttaa                               4596


<210>  830
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 
1               5                   10                  15      


Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 
            20                  25                  30          


Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 
        35                  40                  45              


Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 
    50                  55                  60                  


Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 
65                  70                  75                  80  


Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 
                85                  90                  95      


Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 
            100                 105                 110         


Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 
        115                 120                 125             


Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 
    130                 135                 140                 


Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 
145                 150                 155                 160 


Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 
                165                 170                 175     


Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 
            180                 185                 190         


Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 
        195                 200                 205             


Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 
    210                 215                 220                 


Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 
225                 230                 235                 240 


Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 
                245                 250                 255     


Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 
            260                 265                 270         


Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 
        275                 280                 285             


Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 
    290                 295                 300                 


Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 
305                 310                 315                 320 


Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 
                325                 330                 335     


Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 
            340                 345                 350         


Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 
        355                 360                 365             


Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 
    370                 375                 380                 


Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 
385                 390                 395                 400 


Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 
                405                 410                 415     


Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His 
            420                 425                 430         


Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 
        435                 440                 445             


Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 
    450                 455                 460                 


Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys 
465                 470                 475                 480 


Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 
                485                 490                 495     


Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 
            500                 505                 510         


Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu 
        515                 520                 525             


Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 
    530                 535                 540                 


Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 
545                 550                 555                 560 


Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro 
                565                 570                 575     


Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu 
            580                 585                 590         


Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys Trp 
        595                 600                 605             


Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala 
    610                 615                 620                 


Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys Tyr 
625                 630                 635                 640 


Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys 
                645                 650                 655     


Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 
            660                 665                 670         


Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln 
        675                 680                 685             


Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 
    690                 695                 700                 


Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp 
705                 710                 715                 720 


Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 
                725                 730                 735     


Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 
            740                 745                 750         


Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile 
        755                 760                 765             


Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu 
    770                 775                 780                 


Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser 
785                 790                 795                 800 


Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg Leu 
                805                 810                 815     


Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp Asp 
            820                 825                 830         


Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 
        835                 840                 845             


Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile 
    850                 855                 860                 


Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu Met 
865                 870                 875                 880 


Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys 
                885                 890                 895     


Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu 
            900                 905                 910         


Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val 
        915                 920                 925             


Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 
    930                 935                 940                 


Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr 
945                 950                 955                 960 


His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 
                965                 970                 975     


Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln 
            980                 985                 990         


Thr Ser Leu Thr Cys Asn Ser Met  Val Leu Phe Asp His  Val Gly Cys 
        995                 1000                 1005             


Leu Lys  Lys Tyr Asp Thr Val  Leu Asp Ile Leu Arg  Asp Phe Phe 
    1010                 1015                 1020             


Glu Leu  Arg Leu Lys Tyr Tyr  Gly Leu Arg Lys Glu  Trp Leu Leu 
    1025                 1030                 1035             


Gly Met  Leu Gly Ala Glu Ser  Ala Lys Leu Asn Asn  Gln Ala Arg 
    1040                 1045                 1050             


Phe Ile  Leu Glu Lys Ile Asp  Gly Lys Ile Ile Ile  Glu Asn Lys 
    1055                 1060                 1065             


Pro Lys  Lys Glu Leu Ile Lys  Val Leu Ile Gln Arg  Gly Tyr Asp 
    1070                 1075                 1080             


Ser Asp  Pro Val Lys Ala Trp  Lys Glu Ala Gln Gln  Lys Val Pro 
    1085                 1090                 1095             


Asp Glu  Glu Glu Asn Glu Glu  Ser Asp Asn Glu Lys  Glu Thr Glu 
    1100                 1105                 1110             


Lys Ser  Asp Ser Val Thr Asp  Ser Gly Pro Thr Phe  Asn Tyr Leu 
    1115                 1120                 1125             


Leu Asp  Met Pro Leu Trp Tyr  Leu Thr Lys Glu Lys  Lys Asp Glu 
    1130                 1135                 1140             


Leu Cys  Arg Leu Arg Asn Glu  Lys Glu Gln Glu Leu  Asp Thr Leu 
    1145                 1150                 1155             


Lys Arg  Lys Ser Pro Ser Asp  Leu Trp Lys Glu Asp  Leu Ala Thr 
    1160                 1165                 1170             


Phe Ile  Glu Glu Leu Glu Ala  Val Glu Ala Lys Glu  Lys Gln Asp 
    1175                 1180                 1185             


Glu Gln  Val Gly Leu Pro Gly  Lys Gly Gly Lys Ala  Lys Gly Lys 
    1190                 1195                 1200             


Lys Thr  Gln Met Ala Glu Val  Leu Pro Ser Pro Arg  Gly Gln Arg 
    1205                 1210                 1215             


Val Ile  Pro Arg Ile Thr Ile  Glu Met Lys Ala Glu  Ala Glu Lys 
    1220                 1225                 1230             


Lys Asn  Lys Lys Lys Ile Lys  Asn Glu Asn Thr Glu  Gly Ser Pro 
    1235                 1240                 1245             


Gln Glu  Asp Gly Val Glu Leu  Glu Gly Leu Lys Gln  Arg Leu Glu 
    1250                 1255                 1260             


Lys Lys  Gln Lys Arg Glu Pro  Gly Thr Lys Thr Lys  Lys Gln Thr 
    1265                 1270                 1275             


Thr Leu  Ala Phe Lys Pro Ile  Lys Lys Gly Lys Lys  Arg Asn Pro 
    1280                 1285                 1290             


Trp Ser  Asp Ser Glu Ser Asp  Arg Ser Ser Asp Glu  Ser Asn Phe 
    1295                 1300                 1305             


Asp Val  Pro Pro Arg Glu Thr  Glu Pro Arg Arg Ala  Ala Thr Lys 
    1310                 1315                 1320             


Thr Lys  Phe Thr Met Asp Leu  Asp Ser Asp Glu Asp  Phe Ser Asp 
    1325                 1330                 1335             


Phe Asp  Glu Lys Thr Asp Asp  Glu Asp Phe Val Pro  Ser Asp Ala 
    1340                 1345                 1350             


Ser Pro  Pro Lys Thr Lys Thr  Ser Pro Lys Leu Ser  Asn Lys Glu 
    1355                 1360                 1365             


Leu Lys  Pro Gln Lys Ser Val  Val Ser Asp Leu Glu  Ala Asp Asp 
    1370                 1375                 1380             


Val Lys  Gly Ser Val Pro Leu  Ser Ser Ser Pro Pro  Ala Thr His 
    1385                 1390                 1395             


Phe Pro  Asp Glu Thr Glu Ile  Thr Asn Pro Val Pro  Lys Lys Asn 
    1400                 1405                 1410             


Val Thr  Val Lys Lys Thr Ala  Ala Lys Ser Gln Ser  Ser Thr Ser 
    1415                 1420                 1425             


Thr Thr  Gly Ala Lys Lys Arg  Ala Ala Pro Lys Gly  Thr Lys Arg 
    1430                 1435                 1440             


Asp Pro  Ala Leu Asn Ser Gly  Val Ser Gln Lys Pro  Asp Pro Ala 
    1445                 1450                 1455             


Lys Thr  Lys Asn Arg Arg Lys  Arg Lys Pro Ser Thr  Ser Asp Asp 
    1460                 1465                 1470             


Ser Asp  Ser Asn Phe Glu Lys  Ile Val Ser Lys Ala  Val Thr Ser 
    1475                 1480                 1485             


Lys Lys  Ser Lys Gly Glu Ser  Asp Asp Phe His Met  Asp Phe Asp 
    1490                 1495                 1500             


Ser Ala  Val Ala Pro Arg Ala  Lys Ser Val Arg Ala  Lys Lys Pro 
    1505                 1510                 1515             


Ile Lys  Tyr Leu Glu Glu Ser  Asp Glu Asp Asp Leu  Phe 
    1520                 1525                 1530     


<210>  831
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  831
atggattgta gagagatgga cttatatgag gactaccagt ccccgtttga ttttgatgca       60

ggagtgaaca aaagctatct ctacttgtct cctagtggaa attcatctcc acccggatca      120

cctactcttc agaaatttgg tctgctgaga acagacccag tccctgagga aggagaagat      180

gttgctgcca cgatcagtgc cacagagacc ctctcggaag aggagcagga agagctaaga      240

agagaacttg caaaggtaga agaagaaatc cagactctgt ctcaagtgtt agcagcaaaa      300

gagaagcatc tagcagagat caagcggaaa cttggaatca attctctaca ggaactaaaa      360

cagaacattg ccaaagggtg gcaagacgtg acagcaacat ctgcttacaa gaagacatct      420

gaaaccttat cccaggctgg acagaaggcc tcagctgctt tttcgtctgt tggctcagtc      480

atcaccaaaa agctggaaga tgtaaaaaac tccccaactt ttaaatcatt tgaagaaaag      540

gtcgaaaact taaagtctaa agtaggggga accaagcctg ctggtggtga ttttggagaa      600

gtcttgaatt cggctgcaaa tgctagtgcc accaccacgg agcctcttcc agaaaagaca      660

caggagagcc tgtga                                                       675


<210>  832
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  832

Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140                 


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160 


Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser 
                165                 170                 175     


Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys 
            180                 185                 190         


Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala 
        195                 200                 205             


Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
    210                 215                 220                 


<210>  833
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  833
atggcagagc tgtgccccct ggccgaggag ctgtcgtgct ccatctgcct ggagcccttc       60

aaggagccgg tcaccactcc gtgcggccac aacttctgcg ggtcgtgcct gaatgagacg      120

tgggcagtcc agggctcgcc atacctgtgc ccgcagtgcc gcgccgtcta ccaggcgcga      180

ccgcagctgc acaagaacac ggtgctgtgc aacgtggtgg agcagttcct gcaggccgac      240

ctggcccggg agccacccgc cgacgtctgg acgccgcccg cccgcgcctc tgcacccagc      300

ccgaatgccc aggtggcctg cgaccactgc ctgaaggagg ccgccgtgaa gacgtgcttg      360

gtgtgcatgg cctccttctg tcaggagcac ctgcagccgc acttcgacag ccccgccttc      420

caggaccacc cgctgcagcc gcccgttcgc gacctgttgc gccgcaaatg ttcccagcac      480

aatcggctgc gggaattttt ctgccccgag cacagcgagt gcatctgcca catctgcctg      540

gtggagcata agacctgctc tcccgcgtcc ctgagccagg ccagcgccga cctggaggcc      600

accctgaggc acaaactaac tgtcatgtac agtcagatca acggggcgtc gagagcactg      660

gatgatgtga gaaacaggca gcaggatgtg cggatgactg caaacagaaa ggtggagcag      720

ctacaacaag aatacacgga aatgaaggct ctcttggacg cctcagagac cacctcgaca      780

aggaagataa aggaagagga gaagagggtc aacagcaagt ttgacaccat ttatcagatt      840

ctcctcaaga agaagagtga gatccagacc ttgaaggagg agattgaaca gagcctgacc      900

aagagggatg agttcgagtt tctggagaaa gcatcaaaac tgcgaggaat ctcaacaaag      960

ccagtctaca tccccgaggt ggaactgaac cacaagctga taaaaggcat ccaccagagc     1020

accatagacc tcaaaaacga gctgaagcag tgcatcgggc ggctccagga gcccaccccc     1080

agttcaggtg accctggaga gcatgaccca gcgtccacac acaaatccac acgccctgtg     1140

aagaaggtct ccaaagagga aaagaaatcc aagaaacctc cccctgtccc tgccttaccc     1200

agcaagcttc ccacgtttgg agccccggaa cagttagtgg atttaaaaca agctggcttg     1260

gaggctgcag ccaaagccac cagctcacat ccgaactcaa catctctcaa ggccaaggtg     1320

ctggagacct tcctggccaa gtccagacct gagctcctgg agtattacat taaagtcatc     1380

ctggactaca acaccgccca caacaaagtg gctctgtcag agtgctatac agtagcttct     1440

gtggctgaga tgcctcagaa ctaccggccg catccccaga ggttcacata ctgctctcag     1500

gtgctgggcc tgcactgcta caagaagggg atccactact gggaggtgga gctgcagaag     1560

aacaacttct gtggggtagg catctgctac ggaagcatga accggcaggg cccagaaagc     1620

aggctcggcc gcaacagcgc ctcctggtgc gtggagtggt tcaacaccaa gatctctgcc     1680

tggcacaata acgtggagaa aaccctgccc tccaccaagg ccacgcgggt gggcgtgctt     1740

ctcaactgtg accacggctt tgtcatcttc ttcgctgttg ccgacaaggt ccacctgatg     1800

tataagttca gggtggactt tactgaggct ttgtacccgg ctttctgggt attttctgct     1860

ggtgccacac tctccatctg ctcccccaag tag                                  1893


<210>  834
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys 
1               5                   10                  15      


Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe 
            20                  25                  30          


Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr 
        35                  40                  45              


Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His 
    50                  55                  60                  


Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp 
65                  70                  75                  80  


Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala 
                85                  90                  95      


Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys 
            100                 105                 110         


Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln 
        115                 120                 125             


Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro 
    130                 135                 140                 


Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His 
145                 150                 155                 160 


Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys 
                165                 170                 175     


His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser 
            180                 185                 190         


Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val 
        195                 200                 205             


Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg 
    210                 215                 220                 


Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln 
225                 230                 235                 240 


Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu 
                245                 250                 255     


Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser 
            260                 265                 270         


Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile 
        275                 280                 285             


Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu 
    290                 295                 300                 


Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys 
305                 310                 315                 320 


Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly 
                325                 330                 335     


Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile 
            340                 345                 350         


Gly Arg Leu Gln Glu Pro Thr Pro Ser Ser Gly Asp Pro Gly Glu His 
        355                 360                 365             


Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser 
    370                 375                 380                 


Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro 
385                 390                 395                 400 


Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys 
                405                 410                 415     


Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn 
            420                 425                 430         


Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser 
        435                 440                 445             


Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn 
    450                 455                 460                 


Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser 
465                 470                 475                 480 


Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr 
                485                 490                 495     


Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His 
            500                 505                 510         


Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile 
        515                 520                 525             


Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg 
    530                 535                 540                 


Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala 
545                 550                 555                 560 


Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg 
                565                 570                 575     


Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala 
            580                 585                 590         


Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr 
        595                 600                 605             


Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu 
    610                 615                 620                 


Ser Ile Cys Ser Pro Lys 
625                 630 


<210>  835
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  835
atggcggcct ccgcggcggc agcctcggca gcagcggcct cggccgcctc tggcagcccg       60

ggcccgggcg agggctccgc tggcggcgaa aagcgctcca ccgccccttc ggccgcagcc      120

tcggcctctg cctcagccgc ggcgtcgtcg cccgcggggg gcggcgccga ggcgctggag      180

ctgctggagc actgcggcgt gtgcagagag cgcctgcgac ccgagaggga gccccgcctg      240

ctgccctgtt tgcactcggc ctgtagtgcc tgcttagggc ccgcggcccc cgccgccgcc      300

aacagctcgg gggacggcgg ggcggcgggc gacggcaccg tggtggactg tcccgtgtgc      360

aagcaacagt gcttctccaa agacatcgtg gagaattatt tcatgcgtga tagtggcagc      420

aaggctgcca ccgacgccca ggatgcgaac cagtgctgca ctagctgtga ggataatgcc      480

ccagccacca gctactgtgt ggagtgctcg gagcctctgt gtgagacctg tgtagaggcg      540

caccagcggg tgaagtacac caaggaccat actgtgcgct ctactgggcc agccaagtct      600

cgggatggtg aacgtactgt ctattgcaac gtacacaagc atgaacccct tgtgctgttt      660

tgtgagagct gtgatactct cacctgccga gactgccagc tcaatgccca caaggaccac      720

cagtaccagt tcttagagga tgcagtgagg aaccagcgca agctcctggc ctcactggtg      780

aagcgccttg gggacaaaca tgcaacattg cagaagagca ccaaggaggt tcgcagctca      840

atccgccagg tgtctgacgt acagaagcgt gtgcaagtgg atgtcaagat ggccatcctg      900

cagatcatga aggagctgaa taagcggggc cgtgtgctgg tcaatgatgc ccagaaggtg      960

actgaggggc agcaggagcg cctggagcgg cagcactgga ccatgaccaa gatccagaag     1020

caccaggagc acattctgcg ctttgcctct tgggctctgg agagtgacaa caacacagcc     1080

cttttgcttt ctaagaagtt gatctacttc cagctgcacc gggccctcaa gatgattgtg     1140

gatcccgtgg agccacatgg cgagatgaag tttcagtggg acctcaatgc ctggaccaag     1200

agtgccgagg cctttggcaa gattgtggca gagcgtcctg gcactaactc aacaggccct     1260

gcacccatgg cccctccaag agccccaggg cccctgagca agcagggctc tggcagcagc     1320

cagcccatgg aggtgcagga aggctatggc tttgggtcag gagatgatcc ctactcaagt     1380

gcagagcccc atgtgtcagg tgtgaaacgg tcccgctcag gtgagggcga ggtgagcggc     1440

cttatgcgca aggtgccacg agtgagcctt gaacgcctgg acctggacct cacagctgac     1500

agccagccac ccgtcttcaa ggtcttccca ggcagtacca ctgaggacta caaccttatt     1560

gttattgaac gtggcgctgc cgctgcagct accggccagc cagggactgc gcctgcagga     1620

acccctggtg ccccacccct ggctggcatg gccattgtca aggaggagga gacggaggct     1680

gccattggag cccctcctac tgccactgag ggccctgaga ccaaacctgt gcttatggct     1740

cttgcggagg gtcctggtgc tgagggtccc cgcctggcct cacctagtgg cagcaccagc     1800

tcagggctgg aggtggtggc tcctgagggt acctcagccc caggtggtgg cccgggaacc     1860

ctggatgaca gtgccaccat ttgccgtgtc tgccagaagc caggcgatct ggttatgtgc     1920

aaccagtgtg agttttgttt ccacctggac tgtcacctgc cggccctgca ggatgtacca     1980

ggggaggagt ggagctgctc actctgccat gtgctccctg acctgaagga ggaggatggc     2040

agcctcagcc tggatggtgc agacagcact ggcgtggtgg ccaagctctc accagccaac     2100

cagcggaaat gtgagcgtgt actgctggcc ctattctgtc acgaaccctg ccgccccctg     2160

catcagctgg ctaccgactc caccttctcc ctggaccagc ccggtggcac cctggatctg     2220

accctgatcc gtgcccgcct ccaggagaag ttgtcacctc cctacagctc cccacaggag     2280

tttgcccagg atgtgggccg catgttcaag caattcaaca agttaactga ggacaaggca     2340

gacgtgcagt ccatcatcgg cctgcagcgc ttcttcgaga cgcgcatgaa cgaggccttc     2400

ggtgacacca agttctctgc tgtgctggtg gagcccccgc cgatgagcct gcctggtgct     2460

ggcctgagtt cccaggagct gtctggtggc cctggtgatg gcccctga                  2508


<210>  836
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  836

Met Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Gly Ser Pro Gly Pro Gly Glu Gly Ser Ala Gly Gly Glu Lys Arg 
            20                  25                  30          


Ser Thr Ala Pro Ser Ala Ala Ala Ser Ala Ser Ala Ser Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Ala Gly Gly Gly Ala Glu Ala Leu Glu Leu Leu Glu His 
    50                  55                  60                  


Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Glu Pro Arg Leu 
65                  70                  75                  80  


Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Asn Ser Ser Gly Asp Gly Gly Ala Ala Gly Asp Gly 
            100                 105                 110         


Thr Val Val Asp Cys Pro Val Cys Lys Gln Gln Cys Phe Ser Lys Asp 
        115                 120                 125             


Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ala Thr 
    130                 135                 140                 


Asp Ala Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn Ala 
145                 150                 155                 160 


Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu Thr 
                165                 170                 175     


Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr Val 
            180                 185                 190         


Arg Ser Thr Gly Pro Ala Lys Ser Arg Asp Gly Glu Arg Thr Val Tyr 
        195                 200                 205             


Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser Cys 
    210                 215                 220                 


Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp His 
225                 230                 235                 240 


Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu Leu 
                245                 250                 255     


Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln Lys 
            260                 265                 270         


Ser Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val Gln 
        275                 280                 285             


Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met Lys 
    290                 295                 300                 


Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys Val 
305                 310                 315                 320 


Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met Thr 
                325                 330                 335     


Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp Ala 
            340                 345                 350         


Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu Ile 
        355                 360                 365             


Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val Glu 
    370                 375                 380                 


Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr Lys 
385                 390                 395                 400 


Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr Asn 
                405                 410                 415     


Ser Thr Gly Pro Ala Pro Met Ala Pro Pro Arg Ala Pro Gly Pro Leu 
            420                 425                 430         


Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu Gly 
        435                 440                 445             


Tyr Gly Phe Gly Ser Gly Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Val Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Met Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ala Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Thr Gly Gln Pro Gly Thr Ala Pro Ala Gly Thr Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Ala Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Thr Ala Thr Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Ala Leu Ala Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Gly Thr Ser Ala Pro Gly Gly Gly Pro Gly Thr Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Glu Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Met Ser 
                805                 810                 815     


Leu Pro Gly Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Gly Pro Gly 
            820                 825                 830         


Asp Gly Pro 
        835 


<210>  837
<211>  3564
<212>  DNA
<213>  Homo sapiens

<400>  837
atgcctctgc gccactgggg gatggccagg ggcagtaagc ccgttgggga tggagcccag       60

cccatggctg ccatgggagg cctgaaggtg cttctgcact gggctggtcc aggcggcggg      120

gagccctggg tcactttcag tgagtcatcg ctgacagctg aggaagtctg catccacatt      180

gcacataaag ttggtatcac tcctccttgc ttcaatctct ttgccctctt cgatgctcag      240

gcccaagtct ggttgccccc aaaccacatc ctagagatcc ccagagatgc aagcctgatg      300

ctatatttcc gcataaggtt ttatttccgg aactggcatg gcatgaatcc tcgggaaccg      360

gctgtgtacc gttgtgggcc cccaggaacc gaggcatcct cagatcagac agcacagggg      420

atgcaactcc tggacccagc ctcatttgag tacctctttg agcagggcaa gcatgagttt      480

gtgaatgacg tggcatcact gtgggagctg tcgaccgagg aggagatcca ccactttaag      540

aatgagagcc tgggcatggc ctttctgcac ctctgtcacc tcgctctccg ccatggcatc      600

cccctggagg aggtggccaa gaagaccagc ttcaaggact gcatcccgcg ctccttccgc      660

cggcatatcc ggcagcacag cgccctgacc cggctgcgcc ttcggaacgt cttccgcagg      720

ttcctgcggg acttccagcc gggccgactc tcccagcaga tggtcatggt caaataccta      780

gccacactcg agcggctggc accccgcttc ggcacagagc gtgtgcccgt gtgccacctg      840

aggctgctgg cccaggccga gggggagccc tgctacatcc gggacagtgg ggtggcccct      900

acagaccctg gccctgagtc tgctgctggg cccccaaccc acgaggtgct ggtgacaggc      960

actggtggca tccagtggtg gccagtagag gaggaggtga acaaggagga gggttctagt     1020

ggcagcagtg gcaggaaccc ccaagccagc ctgtttggga agaaggccaa ggctcacaag     1080

gcagtcggcc agccggcaga caggccgcgg gagccactgt gggcctactt ctgtgacttc     1140

cgggacatca cccacgtggt gctgaaagag cactgtgtca gcatccaccg gcaggacaac     1200

aagtgcctgg agctgagctt gccttcccgg gctgcggcgc tgtccttcgt gtcgctggtg     1260

gacggctatt tccgcctgac ggccgactcc agccactacc tgtgccacga ggtggctccc     1320

ccacggctgg tgatgagcat ccgggatggg atccacggac ccctgctgga gccatttgtg     1380

caggccaagc tgcggcccga ggacggcctg tacctcattc actggagcac cagccacccc     1440

taccgcctga tcctcacagt ggcccagcgt agccaggcac cagacggcat gcagagcttg     1500

cggctccgaa agttccccat tgagcagcag gacggggcct tcgtgctgga gggctggggc     1560

cggtccttcc ccagcgttcg ggaacttggg gctgccttgc agggctgctt gctgagggcc     1620

ggggatgact gcttctctct gcgtcgctgt tgcctgcccc aaccaggaga aacctccaat     1680

ctcatcatca tgcggggggc tcgggccagc cccaggacac tcaacctcag ccagctcagc     1740

ttccaccggg ttgaccagaa ggagatcacc cagctgtccc acttgggcca gggcacaagg     1800

accaacgtgt atgagggccg cctgcgagtg gagggcagcg gggaccctga ggagggcaag     1860

atggatgacg aggaccccct cgtgcctggc agggaccgtg ggcaggagct acgagtggtg     1920

ctcaaagtgc tggaccctag tcaccatgac atcgccctgg ccttctacga gacagccagc     1980

ctcatgagcc aggtctccca cacgcacctg gccttcgtgc atggcgtctg tgtgcgcggc     2040

cctgaaaata tcatggtgac agagtacgtg gagcacggac ccctggatgt gtggctgcgg     2100

agggagcggg gccatgtgcc catggcttgg aagatggtgg tggcccagca gctggccagc     2160

gccctcagct acctggagaa caagaacctg gttcatggta atgtgtgtgg ccggaacatc     2220

ctgctggccc ggctggggtt ggcagagggc accagcccct tcatcaagct gagtgatcct     2280

ggcgtgggcc tgggcgccct ctccagggag gagcgggtgg agaggatccc ctggctggcc     2340

cccgaatgcc taccaggtgg ggccaacagc ctaagcaccg ccatggacaa gtgggggttt     2400

ggcgccaccc tcctggagat ctgctttgac ggagaggccc ctctgcagag ccgcagtccc     2460

tccgagaagg agcatttcta ccagaggcag caccggctgc ccgagccctc ctgcccacag     2520

ctggccacac tcaccagcca gtgtctgacc tatgagccaa cccagaggcc atcattccgc     2580

accatcctgc gtgacctcac ccggctgcag ccccacaatc ttgctgacgt cttgactgtg     2640

aacccggact caccggcgtc ggaccctacg gttttccaca agcgctattt gaaaaagatc     2700

cgagatctgg gcgagggtca cttcggcaag gtcagcttgt actgctacga tccgaccaac     2760

gacggcactg gcgagatggt ggcggtgaaa gccctcaagg cagactgcgg cccccagcac     2820

cgctcgggct ggaagcagga gattgacatt ctgcgcacgc tctaccacga gcacatcatc     2880

aagtacaagg gctgctgcga ggaccaaggc gagaagtcgc tgcagctggt catggagtac     2940

gtgcccctgg gcagcctccg agactacctg ccccggcaca gcatcgggct ggcccagctg     3000

ctgctcttcg cccagcagat ctgcgagggc atggcctatc tgcacgcgca gcactacatc     3060

caccgagacc tagccgcgcg caacgtgctg ctggacaacg acaggctggt caagatcggg     3120

gactttggcc tagccaaggc cgtgcccgaa ggccacgagt actaccgcgt gcgcgaggat     3180

ggggacagcc ccgtgttctg gtatgcccca gagtgcctga aggagtataa gttctactat     3240

gcgtcagatg tctggtcctt cggggtgacc ctgtatgagc tgctgacgca ctgtgactcc     3300

agccagagcc cccccacgaa attccttgag ctcataggca ttgctcaggg tcagatgaca     3360

gttctgagac tcactgagtt gctggaacga ggggagaggc tgccacggcc cgacaaatgt     3420

ccctgtgagg tctatcatct catgaagaac tgctgggaga cagaggcgtc ctttcgccca     3480

accttcgaga acctcatacc cattctgaag acagtccatg agaagtacca aggccaggcc     3540

ccttcagtgt tcagcgtgtg ctga                                            3564


<210>  838
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  838

Met Pro Leu Arg His Trp Gly Met Ala Arg Gly Ser Lys Pro Val Gly 
1               5                   10                  15      


Asp Gly Ala Gln Pro Met Ala Ala Met Gly Gly Leu Lys Val Leu Leu 
            20                  25                  30          


His Trp Ala Gly Pro Gly Gly Gly Glu Pro Trp Val Thr Phe Ser Glu 
        35                  40                  45              


Ser Ser Leu Thr Ala Glu Glu Val Cys Ile His Ile Ala His Lys Val 
    50                  55                  60                  


Gly Ile Thr Pro Pro Cys Phe Asn Leu Phe Ala Leu Phe Asp Ala Gln 
65                  70                  75                  80  


Ala Gln Val Trp Leu Pro Pro Asn His Ile Leu Glu Ile Pro Arg Asp 
                85                  90                  95      


Ala Ser Leu Met Leu Tyr Phe Arg Ile Arg Phe Tyr Phe Arg Asn Trp 
            100                 105                 110         


His Gly Met Asn Pro Arg Glu Pro Ala Val Tyr Arg Cys Gly Pro Pro 
        115                 120                 125             


Gly Thr Glu Ala Ser Ser Asp Gln Thr Ala Gln Gly Met Gln Leu Leu 
    130                 135                 140                 


Asp Pro Ala Ser Phe Glu Tyr Leu Phe Glu Gln Gly Lys His Glu Phe 
145                 150                 155                 160 


Val Asn Asp Val Ala Ser Leu Trp Glu Leu Ser Thr Glu Glu Glu Ile 
                165                 170                 175     


His His Phe Lys Asn Glu Ser Leu Gly Met Ala Phe Leu His Leu Cys 
            180                 185                 190         


His Leu Ala Leu Arg His Gly Ile Pro Leu Glu Glu Val Ala Lys Lys 
        195                 200                 205             


Thr Ser Phe Lys Asp Cys Ile Pro Arg Ser Phe Arg Arg His Ile Arg 
    210                 215                 220                 


Gln His Ser Ala Leu Thr Arg Leu Arg Leu Arg Asn Val Phe Arg Arg 
225                 230                 235                 240 


Phe Leu Arg Asp Phe Gln Pro Gly Arg Leu Ser Gln Gln Met Val Met 
                245                 250                 255     


Val Lys Tyr Leu Ala Thr Leu Glu Arg Leu Ala Pro Arg Phe Gly Thr 
            260                 265                 270         


Glu Arg Val Pro Val Cys His Leu Arg Leu Leu Ala Gln Ala Glu Gly 
        275                 280                 285             


Glu Pro Cys Tyr Ile Arg Asp Ser Gly Val Ala Pro Thr Asp Pro Gly 
    290                 295                 300                 


Pro Glu Ser Ala Ala Gly Pro Pro Thr His Glu Val Leu Val Thr Gly 
305                 310                 315                 320 


Thr Gly Gly Ile Gln Trp Trp Pro Val Glu Glu Glu Val Asn Lys Glu 
                325                 330                 335     


Glu Gly Ser Ser Gly Ser Ser Gly Arg Asn Pro Gln Ala Ser Leu Phe 
            340                 345                 350         


Gly Lys Lys Ala Lys Ala His Lys Ala Val Gly Gln Pro Ala Asp Arg 
        355                 360                 365             


Pro Arg Glu Pro Leu Trp Ala Tyr Phe Cys Asp Phe Arg Asp Ile Thr 
    370                 375                 380                 


His Val Val Leu Lys Glu His Cys Val Ser Ile His Arg Gln Asp Asn 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Ser Leu Pro Ser Arg Ala Ala Ala Leu Ser Phe 
                405                 410                 415     


Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ser Ser His 
            420                 425                 430         


Tyr Leu Cys His Glu Val Ala Pro Pro Arg Leu Val Met Ser Ile Arg 
        435                 440                 445             


Asp Gly Ile His Gly Pro Leu Leu Glu Pro Phe Val Gln Ala Lys Leu 
    450                 455                 460                 


Arg Pro Glu Asp Gly Leu Tyr Leu Ile His Trp Ser Thr Ser His Pro 
465                 470                 475                 480 


Tyr Arg Leu Ile Leu Thr Val Ala Gln Arg Ser Gln Ala Pro Asp Gly 
                485                 490                 495     


Met Gln Ser Leu Arg Leu Arg Lys Phe Pro Ile Glu Gln Gln Asp Gly 
            500                 505                 510         


Ala Phe Val Leu Glu Gly Trp Gly Arg Ser Phe Pro Ser Val Arg Glu 
        515                 520                 525             


Leu Gly Ala Ala Leu Gln Gly Cys Leu Leu Arg Ala Gly Asp Asp Cys 
    530                 535                 540                 


Phe Ser Leu Arg Arg Cys Cys Leu Pro Gln Pro Gly Glu Thr Ser Asn 
545                 550                 555                 560 


Leu Ile Ile Met Arg Gly Ala Arg Ala Ser Pro Arg Thr Leu Asn Leu 
                565                 570                 575     


Ser Gln Leu Ser Phe His Arg Val Asp Gln Lys Glu Ile Thr Gln Leu 
            580                 585                 590         


Ser His Leu Gly Gln Gly Thr Arg Thr Asn Val Tyr Glu Gly Arg Leu 
        595                 600                 605             


Arg Val Glu Gly Ser Gly Asp Pro Glu Glu Gly Lys Met Asp Asp Glu 
    610                 615                 620                 


Asp Pro Leu Val Pro Gly Arg Asp Arg Gly Gln Glu Leu Arg Val Val 
625                 630                 635                 640 


Leu Lys Val Leu Asp Pro Ser His His Asp Ile Ala Leu Ala Phe Tyr 
                645                 650                 655     


Glu Thr Ala Ser Leu Met Ser Gln Val Ser His Thr His Leu Ala Phe 
            660                 665                 670         


Val His Gly Val Cys Val Arg Gly Pro Glu Asn Ile Met Val Thr Glu 
        675                 680                 685             


Tyr Val Glu His Gly Pro Leu Asp Val Trp Leu Arg Arg Glu Arg Gly 
    690                 695                 700                 


His Val Pro Met Ala Trp Lys Met Val Val Ala Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Ala Leu Ser Tyr Leu Glu Asn Lys Asn Leu Val His Gly Asn Val Cys 
                725                 730                 735     


Gly Arg Asn Ile Leu Leu Ala Arg Leu Gly Leu Ala Glu Gly Thr Ser 
            740                 745                 750         


Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Gly Leu Gly Ala Leu Ser 
        755                 760                 765             


Arg Glu Glu Arg Val Glu Arg Ile Pro Trp Leu Ala Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gly Gly Ala Asn Ser Leu Ser Thr Ala Met Asp Lys Trp Gly Phe 
785                 790                 795                 800 


Gly Ala Thr Leu Leu Glu Ile Cys Phe Asp Gly Glu Ala Pro Leu Gln 
                805                 810                 815     


Ser Arg Ser Pro Ser Glu Lys Glu His Phe Tyr Gln Arg Gln His Arg 
            820                 825                 830         


Leu Pro Glu Pro Ser Cys Pro Gln Leu Ala Thr Leu Thr Ser Gln Cys 
        835                 840                 845             


Leu Thr Tyr Glu Pro Thr Gln Arg Pro Ser Phe Arg Thr Ile Leu Arg 
    850                 855                 860                 


Asp Leu Thr Arg Leu Gln Pro His Asn Leu Ala Asp Val Leu Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ser Pro Ala Ser Asp Pro Thr Val Phe His Lys Arg Tyr 
                885                 890                 895     


Leu Lys Lys Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Ser 
            900                 905                 910         


Leu Tyr Cys Tyr Asp Pro Thr Asn Asp Gly Thr Gly Glu Met Val Ala 
        915                 920                 925             


Val Lys Ala Leu Lys Ala Asp Cys Gly Pro Gln His Arg Ser Gly Trp 
    930                 935                 940                 


Lys Gln Glu Ile Asp Ile Leu Arg Thr Leu Tyr His Glu His Ile Ile 
945                 950                 955                 960 


Lys Tyr Lys Gly Cys Cys Glu Asp Gln Gly Glu Lys Ser Leu Gln Leu 
                965                 970                 975     


Val Met Glu Tyr Val Pro Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
            980                 985                 990         


His Ser Ile Gly Leu Ala Gln Leu  Leu Leu Phe Ala Gln  Gln Ile Cys 
        995                 1000                 1005             


Glu Gly  Met Ala Tyr Leu His  Ala Gln His Tyr Ile  His Arg Asp 
    1010                 1015                 1020             


Leu Ala  Ala Arg Asn Val Leu  Leu Asp Asn Asp Arg  Leu Val Lys 
    1025                 1030                 1035             


Ile Gly  Asp Phe Gly Leu Ala  Lys Ala Val Pro Glu  Gly His Glu 
    1040                 1045                 1050             


Tyr Tyr  Arg Val Arg Glu Asp  Gly Asp Ser Pro Val  Phe Trp Tyr 
    1055                 1060                 1065             


Ala Pro  Glu Cys Leu Lys Glu  Tyr Lys Phe Tyr Tyr  Ala Ser Asp 
    1070                 1075                 1080             


Val Trp  Ser Phe Gly Val Thr  Leu Tyr Glu Leu Leu  Thr His Cys 
    1085                 1090                 1095             


Asp Ser  Ser Gln Ser Pro Pro  Thr Lys Phe Leu Glu  Leu Ile Gly 
    1100                 1105                 1110             


Ile Ala  Gln Gly Gln Met Thr  Val Leu Arg Leu Thr  Glu Leu Leu 
    1115                 1120                 1125             


Glu Arg  Gly Glu Arg Leu Pro  Arg Pro Asp Lys Cys  Pro Cys Glu 
    1130                 1135                 1140             


Val Tyr  His Leu Met Lys Asn  Cys Trp Glu Thr Glu  Ala Ser Phe 
    1145                 1150                 1155             


Arg Pro  Thr Phe Glu Asn Leu  Ile Pro Ile Leu Lys  Thr Val His 
    1160                 1165                 1170             


Glu Lys  Tyr Gln Gly Gln Ala  Pro Ser Val Phe Ser  Val Cys 
    1175                 1180                 1185         


<210>  839
<211>  1923
<212>  DNA
<213>  Homo sapiens

<400>  839
atggcactgt cgcgggggct gccccgggag ctggctgagg cggtggccgg gggccgggtg       60

ctggtggtgg gggcgggcgg catcggctgc gagctcctca agaatctcgt gctcaccggt      120

ttctcccaca tcgacctgat tgatctggat actattgatg taagcaacct caacagacag      180

tttttgtttc aaaagaaaca tgttggaaga tcaaaggcac aggttgccaa ggaaagtgta      240

ctgcagtttt acccgaaagc taatatcgtt gcctaccatg acagcatcat gaaccctgac      300

tataatgtgg aatttttccg acagtttata ctggttatga atgctttaga taacagagct      360

gcccgaaacc atgttaatag aatgtgcctg gcagctgatg ttcctcttat tgaaagtgga      420

acagctgggt atcttggaca agtaactact atcaaaaagg gtgtgaccga gtgttatgag      480

tgtcatccta agccgaccca gagaaccttt cctggctgta caattcgtaa cacaccttca      540

gaacctatac attgcatcgt ttgggcaaag tacttgttca accagttgtt tggggaagaa      600

gatgctgatc aagaagtatc tcctgacaga gctgaccctg aagctgcctg ggaaccaacg      660

gaagccgaag ccagagctag agcatctaat gaagatggtg acattaaacg tatttctact      720

aaggaatggg ctaaatcaac tggatatgat ccagttaaac tttttaccaa gctttttaaa      780

gatgacatca ggtatctgtt gacaatggac aaactatggc ggaaaaggaa acctccagtt      840

ccgttggact gggctgaagt acaaagtcaa ggagaagaaa cgaatgcatc agatcaacag      900

aatgaacccc agttaggcct gaaagaccag caggttctag atgtaaagag ctatgcacgt      960

cttttttcaa agagcatcga gactttgaga gttcatttag cagaaaaggg ggatggagct     1020

gagctcatat gggataagga tgacccatct gcaatggatt ttgtcacctc tgctgcaaac     1080

ctcaggatgc atattttcag tatgaatatg aagagtagat ttgatatcaa atcaatggca     1140

gggaacatta ttcctgctat tgctactact aatgcagtaa ttgctgggtt gatagtattg     1200

gaaggattga agattttatc aggaaaaata gaccagtgca gaacaatttt tttgaataaa     1260

caaccaaacc caagaaagaa gcttcttgtg ccttgtgcac tggatcctcc caaccccaat     1320

tgttatgtat gtgccagcaa gccagaggtg actgtgcggc tgaatgtcca taaagtgact     1380

gttctcacct tacaagacaa gatagtgaaa gaaaaatttg ctatggtagc accagatgtc     1440

caaattgaag atgggaaagg aacaatccta atatcttccg aagagggaga gacggaagct     1500

aataatcaca agaagttgtc agaatttgga attagaaatg gcagccggct tcaagcagat     1560

gacttcctcc aggactatac tttattgatc aacatccttc atagtgaaga cctaggaaag     1620

gacgttgaat ttgaagttgt tggtgatgcc ccggaaaaag tggggcccaa acaagctgaa     1680

gatgctgcca aaagcataac caatggcagt gatgatggag ctcagccctc cacctccaca     1740

gctcaagagc aagatgacgt tctcatagtt gattcagatg aagaagattc ttcaaataat     1800

gccgacgtca gtgaagaaga gagaagccgc aagaggaaat tagatgagaa agagaatctc     1860

agtgcaaaga ggtcacgtat agaacagaag gaagagcttg atgatgtcat agcattagat     1920

tga                                                                   1923


<210>  840
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  840

Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu Ala Val Ala 
1               5                   10                  15      


Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly Cys Glu Leu 
            20                  25                  30          


Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp Leu Ile Asp 
        35                  40                  45              


Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe Leu Phe Gln 
    50                  55                  60                  


Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys Glu Ser Val 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His Asp Ser Ile 
                85                  90                  95      


Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe Ile Leu Val 
            100                 105                 110         


Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val Asn Arg Met 
        115                 120                 125             


Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr Ala Gly Tyr 
    130                 135                 140                 


Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu Cys Tyr Glu 
145                 150                 155                 160 


Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys Thr Ile Arg 
                165                 170                 175     


Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala Lys Tyr Leu 
            180                 185                 190         


Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu Val Ser Pro 
        195                 200                 205             


Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu Ala Glu Ala 
    210                 215                 220                 


Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg Ile Ser Thr 
225                 230                 235                 240 


Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys Leu Phe Thr 
                245                 250                 255     


Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met Asp Lys Leu 
            260                 265                 270         


Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala Glu Val Gln 
        275                 280                 285             


Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn Glu Pro Gln 
    290                 295                 300                 


Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser Tyr Ala Arg 
305                 310                 315                 320 


Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu Ala Glu Lys 
                325                 330                 335     


Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro Ser Ala Met 
            340                 345                 350         


Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile Phe Ser Met 
        355                 360                 365             


Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly Asn Ile Ile 
    370                 375                 380                 


Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu Ile Val Leu 
385                 390                 395                 400 


Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys Arg Thr Ile 
                405                 410                 415     


Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu Val Pro Cys 
            420                 425                 430         


Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala Ser Lys Pro 
        435                 440                 445             


Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val Leu Thr Leu 
    450                 455                 460                 


Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala Pro Asp Val 
465                 470                 475                 480 


Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser Glu Glu Gly 
                485                 490                 495     


Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe Gly Ile Arg 
            500                 505                 510         


Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp Tyr Thr Leu 
        515                 520                 525             


Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp Val Glu Phe 
    530                 535                 540                 


Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys Gln Ala Glu 
545                 550                 555                 560 


Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly Ala Gln Pro 
                565                 570                 575     


Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile Val Asp Ser 
            580                 585                 590         


Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu Glu Glu Arg 
        595                 600                 605             


Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser Ala Lys Arg 
    610                 615                 620                 


Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile Ala Leu Asp 
625                 630                 635                 640 


<210>  841
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  841
atgtcgggga tcgccctcag cagactcgcc caggagagga aagcatggag gaaagaccac       60

ccatttggtt tcgtggctgt cccaacaaaa aatcccgatg gcacgatgaa cctcatgaac      120

tgggagtgcg ccattccagg aaagaaaggg actccgtggg aaggaggctt gtttaaacta      180

cggatgcttt tcaaagatga ttatccatct tcgccaccaa aatgtaaatt cgaaccacca      240

ttatttcacc cgaatgtgta cccttcgggg acagtgtgcc tgtccatctt agaggaggac      300

aaggactgga ggccagccat cacaatcaaa cagatcctat taggaataca ggaacttcta      360

aatgaaccaa atatccaaga cccagctcaa gcagaggcct acacgattta ctgccaaaac      420

agagtggagt acgagaaaag ggtccgagca caagccaaga agtttgcgcc ctcataa         477


<210>  842
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  843
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  843
atgtggatcc aggttcggac catggacggg aggcagaccc acacggtgga ctcgctgtcc       60

aggctgacca aggtggagga gctgaggcgg aagatccagg agctgttcca cgtggagcca      120

ggcctgcaga ggctgttcta caggggcaaa cagatggagg acggccatac cctcttcgac      180

tacgaggtcc gcctgaatga caccatccag ctcctggtcc gccagagcct cgtgctcccc      240

cacagcacca aggagcggga ctccgagctc tccgacaccg actccggctg ctgcctgggc      300

cagagtgagt cagacaagtc ctccacccac ggtgaggcgg ccgccgagac tgacagcagg      360

ccagccgatg aggacatgtg ggatgagacg gaattggggc tgtacaaggt caatgagtac      420

gtcgatgctc gggacacgaa catgggggcg tggtttgagg cgcaggtggt cagggtgacg      480

cggaaggccc cctcccggga cgagccctgc agctccacgt ccaggccggc gctggaggag      540

gacgtcattt accacgtgaa atacgacgac tacccggaga acggcgtggt ccagatgaac      600

tccagggacg tccgagcgcg cgcccgcacc atcatcaagt ggcaggacct ggaggtgggc      660

caggtggtca tgctcaacta caaccccgac aaccccaagg agcggggctt ctggtacgac      720

gcggagatct ccaggaagcg cgagaccagg acggcgcggg aactctacgc caacgtggtg      780

ctgggggatg attctctgaa cgactgtcgg atcatcttcg tggacgaagt cttcaagatt      840

gagcggccgg gtgaagggag ccccatggtt gacaacccca tgagacggaa gagcgggccg      900

tcctgcaagc actgcaagga cgacgtgaac agactctgcc gggtctgcgc ctgccacctg      960

tgcgggggcc ggcaggaccc cgacaagcag ctcatgtgcg atgagtgcga catggccttc     1020

cacatctact gcctggaccc gcccctcagc agtgttccca gcgaggacga gtggtactgc     1080

cctgagtgcc ggaatgatgc cagcgaggtg gtactggcgg gagagcggct gagagagagc     1140

aagaagaagg cgaagatggc ctcggccaca tcgtcctcac agcgggactg gggcaagggc     1200

atggcctgtg tgggccgcac caaggaatgt accatcgtcc cgtccaacca ctacggaccc     1260

atcccgggga tccccgtggg caccatgtgg cggttccgag tccaggtcag cgagtcgggt     1320

gtccatcggc cccacgtggc tggcatacac ggccggagca acgacggagc gtactcccta     1380

gtcctggcgg ggggctatga ggatgatgtg gaccatggga attttttcac atacacgggt     1440

agtggtggtc gagatctttc cggcaacaag aggaccgcgg aacagtcttg tgatcagaaa     1500

ctcaccaaca ccaacagggc gctggctctc aactgctttg ctcccatcaa tgaccaagaa     1560

ggggccgagg ccaaggactg gcggtcgggg aagccggtca gggtggtgcg caatgtcaag     1620

ggtggcaaga atagcaagta cgcccccgct gagggcaacc gctacgatgg catctacaag     1680

gttgtgaaat actggcccga gaaggggaag tccgggtttc tcgtgtggcg ctaccttctg     1740

cggagggacg atgatgagcc tggcccttgg acgaaggagg ggaaggaccg gatcaagaag     1800

ctggggctga ccatgcagta tccagaaggc tacctggaag ccctggccaa ccgagagcga     1860

gagaaggaga acagcaagag ggaggaggag gagcagcagg aggggggctt cgcgtccccc     1920

aggacgggca agggcaagtg gaagcggaag tcggcaggag gtggcccgag cagggccggg     1980

tccccgcgcc ggacatccaa gaaaaccaag gtggagccct acagtctcac ggcccagcag     2040

agcagcctca tcagagagga caagagcaac gccaagctgt ggaatgaggt cctggcgtca     2100

ctcaaggacc ggccggcgag cggcagcccg ttccagttgt tcctgagtaa agtggaggag     2160

acgttccagt gtatctgctg tcaggagctg gtgttccggc ccatcacgac cgtgtgccag     2220

cacaacgtgt gcaaggactg cctggacaga tcctttcggg cacaggtgtt cagctgccct     2280

gcctgccgct acgacctggg ccgcagctat gccatgcagg tgaaccagcc tctgcagacc     2340

gtcctcaacc agctcttccc cggctacggc aatggccggt ga                        2382


<210>  844
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  844

Met Trp Ile Gln Val Arg Thr Met Asp Gly Arg Gln Thr His Thr Val 
1               5                   10                  15      


Asp Ser Leu Ser Arg Leu Thr Lys Val Glu Glu Leu Arg Arg Lys Ile 
            20                  25                  30          


Gln Glu Leu Phe His Val Glu Pro Gly Leu Gln Arg Leu Phe Tyr Arg 
        35                  40                  45              


Gly Lys Gln Met Glu Asp Gly His Thr Leu Phe Asp Tyr Glu Val Arg 
    50                  55                  60                  


Leu Asn Asp Thr Ile Gln Leu Leu Val Arg Gln Ser Leu Val Leu Pro 
65                  70                  75                  80  


His Ser Thr Lys Glu Arg Asp Ser Glu Leu Ser Asp Thr Asp Ser Gly 
                85                  90                  95      


Cys Cys Leu Gly Gln Ser Glu Ser Asp Lys Ser Ser Thr His Gly Glu 
            100                 105                 110         


Ala Ala Ala Glu Thr Asp Ser Arg Pro Ala Asp Glu Asp Met Trp Asp 
        115                 120                 125             


Glu Thr Glu Leu Gly Leu Tyr Lys Val Asn Glu Tyr Val Asp Ala Arg 
    130                 135                 140                 


Asp Thr Asn Met Gly Ala Trp Phe Glu Ala Gln Val Val Arg Val Thr 
145                 150                 155                 160 


Arg Lys Ala Pro Ser Arg Asp Glu Pro Cys Ser Ser Thr Ser Arg Pro 
                165                 170                 175     


Ala Leu Glu Glu Asp Val Ile Tyr His Val Lys Tyr Asp Asp Tyr Pro 
            180                 185                 190         


Glu Asn Gly Val Val Gln Met Asn Ser Arg Asp Val Arg Ala Arg Ala 
        195                 200                 205             


Arg Thr Ile Ile Lys Trp Gln Asp Leu Glu Val Gly Gln Val Val Met 
    210                 215                 220                 


Leu Asn Tyr Asn Pro Asp Asn Pro Lys Glu Arg Gly Phe Trp Tyr Asp 
225                 230                 235                 240 


Ala Glu Ile Ser Arg Lys Arg Glu Thr Arg Thr Ala Arg Glu Leu Tyr 
                245                 250                 255     


Ala Asn Val Val Leu Gly Asp Asp Ser Leu Asn Asp Cys Arg Ile Ile 
            260                 265                 270         


Phe Val Asp Glu Val Phe Lys Ile Glu Arg Pro Gly Glu Gly Ser Pro 
        275                 280                 285             


Met Val Asp Asn Pro Met Arg Arg Lys Ser Gly Pro Ser Cys Lys His 
    290                 295                 300                 


Cys Lys Asp Asp Val Asn Arg Leu Cys Arg Val Cys Ala Cys His Leu 
305                 310                 315                 320 


Cys Gly Gly Arg Gln Asp Pro Asp Lys Gln Leu Met Cys Asp Glu Cys 
                325                 330                 335     


Asp Met Ala Phe His Ile Tyr Cys Leu Asp Pro Pro Leu Ser Ser Val 
            340                 345                 350         


Pro Ser Glu Asp Glu Trp Tyr Cys Pro Glu Cys Arg Asn Asp Ala Ser 
        355                 360                 365             


Glu Val Val Leu Ala Gly Glu Arg Leu Arg Glu Ser Lys Lys Lys Ala 
    370                 375                 380                 


Lys Met Ala Ser Ala Thr Ser Ser Ser Gln Arg Asp Trp Gly Lys Gly 
385                 390                 395                 400 


Met Ala Cys Val Gly Arg Thr Lys Glu Cys Thr Ile Val Pro Ser Asn 
                405                 410                 415     


His Tyr Gly Pro Ile Pro Gly Ile Pro Val Gly Thr Met Trp Arg Phe 
            420                 425                 430         


Arg Val Gln Val Ser Glu Ser Gly Val His Arg Pro His Val Ala Gly 
        435                 440                 445             


Ile His Gly Arg Ser Asn Asp Gly Ala Tyr Ser Leu Val Leu Ala Gly 
    450                 455                 460                 


Gly Tyr Glu Asp Asp Val Asp His Gly Asn Phe Phe Thr Tyr Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Arg Asp Leu Ser Gly Asn Lys Arg Thr Ala Glu Gln Ser 
                485                 490                 495     


Cys Asp Gln Lys Leu Thr Asn Thr Asn Arg Ala Leu Ala Leu Asn Cys 
            500                 505                 510         


Phe Ala Pro Ile Asn Asp Gln Glu Gly Ala Glu Ala Lys Asp Trp Arg 
        515                 520                 525             


Ser Gly Lys Pro Val Arg Val Val Arg Asn Val Lys Gly Gly Lys Asn 
    530                 535                 540                 


Ser Lys Tyr Ala Pro Ala Glu Gly Asn Arg Tyr Asp Gly Ile Tyr Lys 
545                 550                 555                 560 


Val Val Lys Tyr Trp Pro Glu Lys Gly Lys Ser Gly Phe Leu Val Trp 
                565                 570                 575     


Arg Tyr Leu Leu Arg Arg Asp Asp Asp Glu Pro Gly Pro Trp Thr Lys 
            580                 585                 590         


Glu Gly Lys Asp Arg Ile Lys Lys Leu Gly Leu Thr Met Gln Tyr Pro 
        595                 600                 605             


Glu Gly Tyr Leu Glu Ala Leu Ala Asn Arg Glu Arg Glu Lys Glu Asn 
    610                 615                 620                 


Ser Lys Arg Glu Glu Glu Glu Gln Gln Glu Gly Gly Phe Ala Ser Pro 
625                 630                 635                 640 


Arg Thr Gly Lys Gly Lys Trp Lys Arg Lys Ser Ala Gly Gly Gly Pro 
                645                 650                 655     


Ser Arg Ala Gly Ser Pro Arg Arg Thr Ser Lys Lys Thr Lys Val Glu 
            660                 665                 670         


Pro Tyr Ser Leu Thr Ala Gln Gln Ser Ser Leu Ile Arg Glu Asp Lys 
        675                 680                 685             


Ser Asn Ala Lys Leu Trp Asn Glu Val Leu Ala Ser Leu Lys Asp Arg 
    690                 695                 700                 


Pro Ala Ser Gly Ser Pro Phe Gln Leu Phe Leu Ser Lys Val Glu Glu 
705                 710                 715                 720 


Thr Phe Gln Cys Ile Cys Cys Gln Glu Leu Val Phe Arg Pro Ile Thr 
                725                 730                 735     


Thr Val Cys Gln His Asn Val Cys Lys Asp Cys Leu Asp Arg Ser Phe 
            740                 745                 750         


Arg Ala Gln Val Phe Ser Cys Pro Ala Cys Arg Tyr Asp Leu Gly Arg 
        755                 760                 765             


Ser Tyr Ala Met Gln Val Asn Gln Pro Leu Gln Thr Val Leu Asn Gln 
    770                 775                 780                 


Leu Phe Pro Gly Tyr Gly Asn Gly Arg 
785                 790             


<210>  845
<211>  3216
<212>  DNA
<213>  Homo sapiens

<400>  845
atgccagcaa ttatgacaat gttagcagac catgcagctc gtcagctgct tgatttcagc       60

caaaaactgg atatcaactt attagataat gtggtgaatt gcttatacca tggagaagga      120

gcccagcaaa gaatggctca agaagtactg acacatttaa aggagcatcc tgatgcttgg      180

acaagagtcg acacaatttt ggaattttct cagaatatga atacgaaata ctatggacta      240

caaattttgg aaaatgtgat aaaaacaagg tggaagattc ttccaaggaa ccagtgcgaa      300

ggaataaaaa aatacgttgt tggcctcatt atcaagacgt catctgaccc aacttgtgta      360

gagaaagaaa aggtgtatat cggaaaatta aatatgatcc ttgttcagat actgaaacaa      420

gaatggccca aacattggcc aacttttatc agtgatattg ttggagcaag taggaccagc      480

gaaagtctct gtcaaaataa tatggtgatt cttaaactct tgagtgaaga agtatttgat      540

ttctctagtg gacagataac ccaagtcaaa tctaagcatt taaaagacag catgtgcaat      600

gaattctcac agatatttca actgtgtcag tttgtaatgg aaaattctca aaatgctcca      660

cttgtacatg caaccttgga aacattgctc agatttctga actggattcc cctgggatat      720

atttttgaga ccaaattaat cagcacattg atttataagt tcctgaatgt tccaatgttt      780

cgaaatgtct ctctgaagtg cctcactgag attgctggtg tgagtgtaag ccaatatgaa      840

gaacaatttg taacactatt tactctgaca atgatgcaac taaagcagat gcttccttta      900

aataccaata ttcgacttgc gtactcaaat ggaaaagatg atgaacagaa cttcattcaa      960

aatctcagtt tgtttctctg cacctttctt aaggaacatg atcaacttat agaaaaaaga     1020

ttaaatctca gggaaactct tatggaggcc cttcattata tgttgttggt atctgaagta     1080

gaagaaactg aaatctttaa aatttgtctt gaatactgga atcatttggc tgctgaactc     1140

tatagagaga gtccattctc tacatctgcc tctccgttgc tttctggaag tcaacatttt     1200

gatgttcctc ccaggagaca gctatatttg cccatgttat tcaaggtccg tttattaatg     1260

gttagtcgaa tggctaaacc agaggaagta ttggttgtag agaatgatca aggagaagtt     1320

gtgagagaat tcatgaagga tacagattcc ataaatttgt ataagaatat gagggaaaca     1380

ttggtttatc ttactcatct ggattatgta gatacagaaa gaataatgac agagaagctt     1440

cacaatcaag tgaatggtac agagtggtca tggaaaaatt tgaatacatt gtgttgggca     1500

ataggctcca ttagtggagc aatgcatgaa gaggacgaaa aacgatttct tgttactgtt     1560

ataaaggatc tattaggatt atgtgaacag aaaagaggca aagataataa agctattatt     1620

gcatcaaata tcatgtacat agtaggtcaa tacccacgtt ttttgagagc tcactggaaa     1680

tttctgaaga ctgtagttaa caagctgttc gaattcatgc atgagaccca tgatggagtc     1740

caggatatgg cttgtgatac tttcattaaa atagcccaaa aatgccgcag gcatttcgtt     1800

caggttcagg ttggagaagt gatgccattt attgatgaaa ttttgaacaa cattaacact     1860

attatttgtg atcttcagcc tcaacaggtt catacgtttt atgaagctgt ggggtacatg     1920

attggtgcac aaacagatca aacagtacaa gaacacttga tagaaaagta catgttactc     1980

cctaatcaag tgtgggatag tataatccag caggcaacca aaaatgtgga tatactgaaa     2040

gatcctgaaa cagtcaagca gcttggtagc attttgaaaa caaatgtgag agcctgcaaa     2100

gctgttggac acccctttgt aattcagctt ggaagaattt atttagatat gcttaatgta     2160

tacaagtgcc tcagtgaaaa tatttctgca gctatccaag ctaatggtga aatggttaca     2220

aagcaaccat tgattagaag tatgcgaact gtaaaaaggg aaactttaaa gttaatatct     2280

ggttgggtga gccgatccaa tgatccacag atggtcgctg aaaattttgt tccccctctg     2340

ttggatgcag ttctcattga ttatcagaga aatgtcccag ctgctagaga accagaagtg     2400

cttagtacta tggccataat tgtcaacaag ttagggggac atataacagc tgaaatacct     2460

caaatatttg atgctgtttt tgaatgcaca ttgaatatga taaataagga ctttgaagaa     2520

tatcctgaac atagaacgaa ctttttctta ctacttcagg ctgtcaattc tcattgtttc     2580

ccagcattcc ttgctattcc acctacacag tttaaacttg ttttggattc catcatttgg     2640

gctttcaaac atactatgag gaatgtcgca gatacgggct tacagatact ttttacactc     2700

ttacaaaatg ttgcacaaga agaagctgca gctcagagtt tttatcaaac ttatttttgt     2760

gatattctcc agcatatctt ttctgttgtg acagacactt cacatactgc tggtttaaca     2820

atgcatgcat caattcttgc atatatgttt aatttggttg aagaaggaaa aataagtaca     2880

tcattaaatc ctggaaatcc agttaacaac caaatctttc ttcaggaata tgtggctaat     2940

ctccttaagt cggccttccc tcacctacaa gatgctcaag taaagctctt tgtgacaggg     3000

cttttcagct taaatcaaga tattcctgct ttcaaggaac atttaagaga tttcctagtt     3060

caaataaagg aatttgcagg tgaagacact tctgatttgt ttttggaaga gagagaaata     3120

gccctacggc aggctgatga agagaaacat aaacgtcaaa tgtctgtccc tggcatcttt     3180

aatccacatg agattccaga agaaatgtgt gattaa                               3216


<210>  846
<211>  1071
<212>  PRT
<213>  Homo sapiens

<400>  846

Met Pro Ala Ile Met Thr Met Leu Ala Asp His Ala Ala Arg Gln Leu 
1               5                   10                  15      


Leu Asp Phe Ser Gln Lys Leu Asp Ile Asn Leu Leu Asp Asn Val Val 
            20                  25                  30          


Asn Cys Leu Tyr His Gly Glu Gly Ala Gln Gln Arg Met Ala Gln Glu 
        35                  40                  45              


Val Leu Thr His Leu Lys Glu His Pro Asp Ala Trp Thr Arg Val Asp 
    50                  55                  60                  


Thr Ile Leu Glu Phe Ser Gln Asn Met Asn Thr Lys Tyr Tyr Gly Leu 
65                  70                  75                  80  


Gln Ile Leu Glu Asn Val Ile Lys Thr Arg Trp Lys Ile Leu Pro Arg 
                85                  90                  95      


Asn Gln Cys Glu Gly Ile Lys Lys Tyr Val Val Gly Leu Ile Ile Lys 
            100                 105                 110         


Thr Ser Ser Asp Pro Thr Cys Val Glu Lys Glu Lys Val Tyr Ile Gly 
        115                 120                 125             


Lys Leu Asn Met Ile Leu Val Gln Ile Leu Lys Gln Glu Trp Pro Lys 
    130                 135                 140                 


His Trp Pro Thr Phe Ile Ser Asp Ile Val Gly Ala Ser Arg Thr Ser 
145                 150                 155                 160 


Glu Ser Leu Cys Gln Asn Asn Met Val Ile Leu Lys Leu Leu Ser Glu 
                165                 170                 175     


Glu Val Phe Asp Phe Ser Ser Gly Gln Ile Thr Gln Val Lys Ser Lys 
            180                 185                 190         


His Leu Lys Asp Ser Met Cys Asn Glu Phe Ser Gln Ile Phe Gln Leu 
        195                 200                 205             


Cys Gln Phe Val Met Glu Asn Ser Gln Asn Ala Pro Leu Val His Ala 
    210                 215                 220                 


Thr Leu Glu Thr Leu Leu Arg Phe Leu Asn Trp Ile Pro Leu Gly Tyr 
225                 230                 235                 240 


Ile Phe Glu Thr Lys Leu Ile Ser Thr Leu Ile Tyr Lys Phe Leu Asn 
                245                 250                 255     


Val Pro Met Phe Arg Asn Val Ser Leu Lys Cys Leu Thr Glu Ile Ala 
            260                 265                 270         


Gly Val Ser Val Ser Gln Tyr Glu Glu Gln Phe Val Thr Leu Phe Thr 
        275                 280                 285             


Leu Thr Met Met Gln Leu Lys Gln Met Leu Pro Leu Asn Thr Asn Ile 
    290                 295                 300                 


Arg Leu Ala Tyr Ser Asn Gly Lys Asp Asp Glu Gln Asn Phe Ile Gln 
305                 310                 315                 320 


Asn Leu Ser Leu Phe Leu Cys Thr Phe Leu Lys Glu His Asp Gln Leu 
                325                 330                 335     


Ile Glu Lys Arg Leu Asn Leu Arg Glu Thr Leu Met Glu Ala Leu His 
            340                 345                 350         


Tyr Met Leu Leu Val Ser Glu Val Glu Glu Thr Glu Ile Phe Lys Ile 
        355                 360                 365             


Cys Leu Glu Tyr Trp Asn His Leu Ala Ala Glu Leu Tyr Arg Glu Ser 
    370                 375                 380                 


Pro Phe Ser Thr Ser Ala Ser Pro Leu Leu Ser Gly Ser Gln His Phe 
385                 390                 395                 400 


Asp Val Pro Pro Arg Arg Gln Leu Tyr Leu Pro Met Leu Phe Lys Val 
                405                 410                 415     


Arg Leu Leu Met Val Ser Arg Met Ala Lys Pro Glu Glu Val Leu Val 
            420                 425                 430         


Val Glu Asn Asp Gln Gly Glu Val Val Arg Glu Phe Met Lys Asp Thr 
        435                 440                 445             


Asp Ser Ile Asn Leu Tyr Lys Asn Met Arg Glu Thr Leu Val Tyr Leu 
    450                 455                 460                 


Thr His Leu Asp Tyr Val Asp Thr Glu Arg Ile Met Thr Glu Lys Leu 
465                 470                 475                 480 


His Asn Gln Val Asn Gly Thr Glu Trp Ser Trp Lys Asn Leu Asn Thr 
                485                 490                 495     


Leu Cys Trp Ala Ile Gly Ser Ile Ser Gly Ala Met His Glu Glu Asp 
            500                 505                 510         


Glu Lys Arg Phe Leu Val Thr Val Ile Lys Asp Leu Leu Gly Leu Cys 
        515                 520                 525             


Glu Gln Lys Arg Gly Lys Asp Asn Lys Ala Ile Ile Ala Ser Asn Ile 
    530                 535                 540                 


Met Tyr Ile Val Gly Gln Tyr Pro Arg Phe Leu Arg Ala His Trp Lys 
545                 550                 555                 560 


Phe Leu Lys Thr Val Val Asn Lys Leu Phe Glu Phe Met His Glu Thr 
                565                 570                 575     


His Asp Gly Val Gln Asp Met Ala Cys Asp Thr Phe Ile Lys Ile Ala 
            580                 585                 590         


Gln Lys Cys Arg Arg His Phe Val Gln Val Gln Val Gly Glu Val Met 
        595                 600                 605             


Pro Phe Ile Asp Glu Ile Leu Asn Asn Ile Asn Thr Ile Ile Cys Asp 
    610                 615                 620                 


Leu Gln Pro Gln Gln Val His Thr Phe Tyr Glu Ala Val Gly Tyr Met 
625                 630                 635                 640 


Ile Gly Ala Gln Thr Asp Gln Thr Val Gln Glu His Leu Ile Glu Lys 
                645                 650                 655     


Tyr Met Leu Leu Pro Asn Gln Val Trp Asp Ser Ile Ile Gln Gln Ala 
            660                 665                 670         


Thr Lys Asn Val Asp Ile Leu Lys Asp Pro Glu Thr Val Lys Gln Leu 
        675                 680                 685             


Gly Ser Ile Leu Lys Thr Asn Val Arg Ala Cys Lys Ala Val Gly His 
    690                 695                 700                 


Pro Phe Val Ile Gln Leu Gly Arg Ile Tyr Leu Asp Met Leu Asn Val 
705                 710                 715                 720 


Tyr Lys Cys Leu Ser Glu Asn Ile Ser Ala Ala Ile Gln Ala Asn Gly 
                725                 730                 735     


Glu Met Val Thr Lys Gln Pro Leu Ile Arg Ser Met Arg Thr Val Lys 
            740                 745                 750         


Arg Glu Thr Leu Lys Leu Ile Ser Gly Trp Val Ser Arg Ser Asn Asp 
        755                 760                 765             


Pro Gln Met Val Ala Glu Asn Phe Val Pro Pro Leu Leu Asp Ala Val 
    770                 775                 780                 


Leu Ile Asp Tyr Gln Arg Asn Val Pro Ala Ala Arg Glu Pro Glu Val 
785                 790                 795                 800 


Leu Ser Thr Met Ala Ile Ile Val Asn Lys Leu Gly Gly His Ile Thr 
                805                 810                 815     


Ala Glu Ile Pro Gln Ile Phe Asp Ala Val Phe Glu Cys Thr Leu Asn 
            820                 825                 830         


Met Ile Asn Lys Asp Phe Glu Glu Tyr Pro Glu His Arg Thr Asn Phe 
        835                 840                 845             


Phe Leu Leu Leu Gln Ala Val Asn Ser His Cys Phe Pro Ala Phe Leu 
    850                 855                 860                 


Ala Ile Pro Pro Thr Gln Phe Lys Leu Val Leu Asp Ser Ile Ile Trp 
865                 870                 875                 880 


Ala Phe Lys His Thr Met Arg Asn Val Ala Asp Thr Gly Leu Gln Ile 
                885                 890                 895     


Leu Phe Thr Leu Leu Gln Asn Val Ala Gln Glu Glu Ala Ala Ala Gln 
            900                 905                 910         


Ser Phe Tyr Gln Thr Tyr Phe Cys Asp Ile Leu Gln His Ile Phe Ser 
        915                 920                 925             


Val Val Thr Asp Thr Ser His Thr Ala Gly Leu Thr Met His Ala Ser 
    930                 935                 940                 


Ile Leu Ala Tyr Met Phe Asn Leu Val Glu Glu Gly Lys Ile Ser Thr 
945                 950                 955                 960 


Ser Leu Asn Pro Gly Asn Pro Val Asn Asn Gln Ile Phe Leu Gln Glu 
                965                 970                 975     


Tyr Val Ala Asn Leu Leu Lys Ser Ala Phe Pro His Leu Gln Asp Ala 
            980                 985                 990         


Gln Val Lys Leu Phe Val Thr Gly  Leu Phe Ser Leu Asn  Gln Asp Ile 
        995                 1000                 1005             


Pro Ala  Phe Lys Glu His Leu  Arg Asp Phe Leu Val  Gln Ile Lys 
    1010                 1015                 1020             


Glu Phe  Ala Gly Glu Asp Thr  Ser Asp Leu Phe Leu  Glu Glu Arg 
    1025                 1030                 1035             


Glu Ile  Ala Leu Arg Gln Ala  Asp Glu Glu Lys His  Lys Arg Gln 
    1040                 1045                 1050             


Met Ser  Val Pro Gly Ile Phe  Asn Pro His Glu Ile  Pro Glu Glu 
    1055                 1060                 1065             


Met Cys  Asp 
    1070     


<210>  847
<211>  1056
<212>  DNA
<213>  Homo sapiens

<400>  847
atgggcaacg ccgccgccgc caagaagggc agcgagcagg agagcgtgaa agaattctta       60

gccaaagcca aagaagattt tcttaaaaaa tgggaaagtc ccgctcagaa cacagcccac      120

ttggatcagt ttgaacgaat caagaccctc ggcacgggct ccttcgggcg ggtgatgctg      180

gtgaaacaca aggagaccgg gaaccactat gccatgaaga tcctcgacaa acagaaggtg      240

gtgaaactga aacagatcga acacaccctg aatgaaaagc gcatcctgca agctgtcaac      300

tttccgttcc tcgtcaaact cgagttctcc ttcaaggaca actcaaactt atacatggtc      360

atggagtacg tgcccggcgg ggagatgttc tcacacctac ggcggatcgg aaggttcagt      420

gagccccatg cccgtttcta cgcggcccag atcgtcctga cctttgagta tctgcactcg      480

ctggatctca tctacaggga cctgaagccg gagaatctgc tcattgacca gcagggctac      540

attcaggtga cagacttcgg tttcgccaag cgcgtgaagg gccgcacttg gaccttgtgc      600

ggcacccctg agtacctggc ccctgagatt atcctgagca aaggctacaa caaggccgtg      660

gactggtggg ccctgggggt tcttatctat gaaatggccg ctggctaccc gcccttcttc      720

gcagaccagc ccatccagat ctatgagaag atcgtctctg ggaaggtgcg cttcccttcc      780

cacttcagct ctgacttgaa ggacctgctg cggaacctcc tgcaggtaga tctcaccaag      840

cgctttggga acctcaagaa tggggtcaac gatatcaaga accacaagtg gtttgccaca      900

actgactgga ttgccatcta ccagaggaag gtggaagctc ccttcatacc aaagtttaaa      960

ggccctgggg atacgagtaa ctttgacgac tatgaggaag aagaaatccg ggtctccatc     1020

aatgagaagt gtggcaagga gttttctgag ttttag                               1056


<210>  848
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  848

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210>  849
<211>  3186
<212>  DNA
<213>  Homo sapiens

<400>  849
cgttgtctca cccgggaagg gaaagcagcc agcagccctc cagccctctt gtgctttccc       60

tgggagtgcg ccccgtgctc agccatggtg gacatggggg ccctggacaa cctgatcgcc      120

aacaccgcct acctgcaggc ccggaagccc tcggactgcg acagcaaaga gctgcagcgg      180

cggcggcgta gcctggccct gcccgggctg cagggctgcg cggagctccg ccagaagctg      240

tccctgaact tccacagcct gtgtgagcag cagcccatcg gtcgccgcct cttccgtgac      300

ttcctagcca cagtgcccac gttccgcaag gcggcaacct tcctagagga cgtgcagaac      360

tgggagctgg ccgaggaggg acccaccaaa gacagcgcgc tgcaggggct ggtggccact      420

tgtgcgagtg cccctgcccc ggggaacccg caacccttcc tcagccaggc cgtggccacc      480

aagtgccaag cagccaccac tgaggaagag cgagtggctg cagtgacgct ggccaaggct      540

gaggccatgg ctttcttgca agagcagccc tttaaggatt tcgtgaccag cgccttctac      600

gacaagtttc tgcagtggaa actcttcgag atgcaaccag tgtcagacaa gtacttcact      660

gagttcagag tgctggggaa aggtggtttt ggggaggtat gtgccgtcca ggtgaaaaac      720

actgggaaga tgtatgcctg taagaaactg gacaagaagc ggctgaagaa gaaaggtggc      780

gagaagatgg ctctcttgga aaaggaaatc ttggagaagg tcagcagccc tttcattgtc      840

tctctggcct atgcctttga gagcaagacc catctctgcc ttgtcatgag cctgatgaat      900

gggggagacc tcaagttcca catctacaac gtgggcacgc gtggcctgga catgagccgg      960

gtgatctttt actcggccca gatagcctgt gggatgctgc acctccatga actcggcatc     1020

gtctatcggg acatgaagcc tgagaatgtg cttctggatg acctcggcaa ctgcaggtta     1080

tctgacctgg ggctggccgt ggagatgaag ggtggcaagc ccatcaccca gagggctgga     1140

accaatggtt acatggctcc tgagatccta atggaaaagg taagttattc ctatcctgtg     1200

gactggtttg ccatgggatg cagcatttat gaaatggttg ctggacgaac accattcaaa     1260

gattacaagg aaaaggtcag taaagaggat ctgaagcaaa gaactctgca agacgaggtc     1320

aaattccagc atgataactt cacagaggaa gcaaaagata tttgcaggct cttcttggct     1380

aagaaaccag agcaacgctt aggaagcaga gaaaagtctg atgatcccag gaaacatcat     1440

ttctttaaaa cgatcaactt tcctcgcctg gaagctggcc taattgaacc cccatttgtg     1500

ccagaccctt cagtggttta tgccaaagac atcgctgaaa ttgatgattt ctctgaggtt     1560

cggggggtgg aatttgatga caaagataag cagttcttca aaaactttgc gacaggtgct     1620

gttcctatag catggcagga agaaattata gaaacgggac tgtttgagga actgaatgac     1680

cccaacagac ctacgggttg tgaggagggt aattcatcca agtctggcgt gtgtttgtta     1740

ttgtaaattg ctctctttac cagacaggca gcaggagtct cggctgacat aatcctcgaa     1800

tgttccacac gtggaaatct gtggaatgag ggctaatcag ttaggaggga catcacaacc     1860

acaaaacaat tcaaaagaca ggcaagctca ctactagaac acattttatt ttctttttct     1920

ttcttcataa agatgagtaa agtctcagtt ttcactgagg gcagggaaaa ggaacactca     1980

ggtttatttt gataaactga aagcatcagc cttttaccat catgtccctg tgtattacgc     2040

aaagtcctag gaacagagaa tggaactttg tggtgtgccc agaaaatgag catttgcaat     2100

tcttagtaaa taatcatttt agtttttctt tgtttatatc tttttttccc ttcatctttc     2160

ttcgcttcta tacttataaa aaggattttg aagctggaaa caaatgtttc tgacattctc     2220

cccctaaaaa ggagtggatt acaatatttt ggcaatgttt taaatcacag aataattttc     2280

aatttcagtg acagtttctt ttgcaatttt gtggaaataa tttactatca taatgttgaa     2340

gcattttaaa cataaacatc catgacatct gtgaattaaa gcattctgta aatttagttg     2400

agtcctttaa gtaatatggt acaaattgct tcaacttgca ctaccatatg ccatcggttc     2460

ccaaactctg ctgaactttg gaatcatcta gggatctttt aaaaaactaa tgcctgattc     2520

ccatccatag acattctgat ccccactccc aggtatgaga acagcttgac catttagaat     2580

ttcagaagct ccccaggtga ttctaatgtg cagcagagtt tggcaggcac tgctgtgcac     2640

atttgaatgt tattacattc aatcttattt tggttgctca aaacttcaat catacatttt     2700

gatggcaact tttcaaatgt ccccaaagca tgtcatttta gtaattgcag tataaatgaa     2760

acaagacagt ctattcatct tatggcttct cttgtccttg cacactttag tttctcacac     2820

gtatcttggg agctcggtct cttggctatt tcaagtcctg aaggagacct atgggcttag     2880

aaattgagtt gaacaggcca ggtgcggtgg ctcatgcctg caattccagc actttgggag     2940

gccaaggcag atggatcatg aggtcagggg ttcaagacta gcctggccaa catgttgtaa     3000

accccgtctc tactaaaaat acaaaaatta gcccggtgtg gtggtgcaca tctataatcc     3060

cagttacccg ggagcctgag gcaggagaat tgcttgaacc caggaggcgg aggttgtagt     3120

gagccaagat cgcaacattg cactccaggc tgggcagcaa gagcaagact ctatctcaaa     3180

aaaaaa                                                                3186


<210>  850
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  850

Met Val Asp Met Gly Ala Leu Asp Asn Leu Ile Ala Asn Thr Ala Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Lys Pro Ser Asp Cys Asp Ser Lys Glu Leu Gln Arg 
            20                  25                  30          


Arg Arg Arg Ser Leu Ala Leu Pro Gly Leu Gln Gly Cys Ala Glu Leu 
        35                  40                  45              


Arg Gln Lys Leu Ser Leu Asn Phe His Ser Leu Cys Glu Gln Gln Pro 
    50                  55                  60                  


Ile Gly Arg Arg Leu Phe Arg Asp Phe Leu Ala Thr Val Pro Thr Phe 
65                  70                  75                  80  


Arg Lys Ala Ala Thr Phe Leu Glu Asp Val Gln Asn Trp Glu Leu Ala 
                85                  90                  95      


Glu Glu Gly Pro Thr Lys Asp Ser Ala Leu Gln Gly Leu Val Ala Thr 
            100                 105                 110         


Cys Ala Ser Ala Pro Ala Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln 
        115                 120                 125             


Ala Val Ala Thr Lys Cys Gln Ala Ala Thr Thr Glu Glu Glu Arg Val 
    130                 135                 140                 


Ala Ala Val Thr Leu Ala Lys Ala Glu Ala Met Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Gln Pro Phe Lys Asp Phe Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu 
                165                 170                 175     


Gln Trp Lys Leu Phe Glu Met Gln Pro Val Ser Asp Lys Tyr Phe Thr 
            180                 185                 190         


Glu Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Val 
        195                 200                 205             


Gln Val Lys Asn Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Leu Lys Lys Lys Gly Gly Glu Lys Met Ala Leu Leu Glu Lys 
225                 230                 235                 240 


Glu Ile Leu Glu Lys Val Ser Ser Pro Phe Ile Val Ser Leu Ala Tyr 
                245                 250                 255     


Ala Phe Glu Ser Lys Thr His Leu Cys Leu Val Met Ser Leu Met Asn 
            260                 265                 270         


Gly Gly Asp Leu Lys Phe His Ile Tyr Asn Val Gly Thr Arg Gly Leu 
        275                 280                 285             


Asp Met Ser Arg Val Ile Phe Tyr Ser Ala Gln Ile Ala Cys Gly Met 
    290                 295                 300                 


Leu His Leu His Glu Leu Gly Ile Val Tyr Arg Asp Met Lys Pro Glu 
305                 310                 315                 320 


Asn Val Leu Leu Asp Asp Leu Gly Asn Cys Arg Leu Ser Asp Leu Gly 
                325                 330                 335     


Leu Ala Val Glu Met Lys Gly Gly Lys Pro Ile Thr Gln Arg Ala Gly 
            340                 345                 350         


Thr Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys Val Ser Tyr 
        355                 360                 365             


Ser Tyr Pro Val Asp Trp Phe Ala Met Gly Cys Ser Ile Tyr Glu Met 
    370                 375                 380                 


Val Ala Gly Arg Thr Pro Phe Lys Asp Tyr Lys Glu Lys Val Ser Lys 
385                 390                 395                 400 


Glu Asp Leu Lys Gln Arg Thr Leu Gln Asp Glu Val Lys Phe Gln His 
                405                 410                 415     


Asp Asn Phe Thr Glu Glu Ala Lys Asp Ile Cys Arg Leu Phe Leu Ala 
            420                 425                 430         


Lys Lys Pro Glu Gln Arg Leu Gly Ser Arg Glu Lys Ser Asp Asp Pro 
        435                 440                 445             


Arg Lys His His Phe Phe Lys Thr Ile Asn Phe Pro Arg Leu Glu Ala 
    450                 455                 460                 


Gly Leu Ile Glu Pro Pro Phe Val Pro Asp Pro Ser Val Val Tyr Ala 
465                 470                 475                 480 


Lys Asp Ile Ala Glu Ile Asp Asp Phe Ser Glu Val Arg Gly Val Glu 
                485                 490                 495     


Phe Asp Asp Lys Asp Lys Gln Phe Phe Lys Asn Phe Ala Thr Gly Ala 
            500                 505                 510         


Val Pro Ile Ala Trp Gln Glu Glu Ile Ile Glu Thr Gly Leu Phe Glu 
        515                 520                 525             


Glu Leu Asn Asp Pro Asn Arg Pro Thr Gly Cys Glu Glu Gly Asn Ser 
    530                 535                 540                 


Ser Lys Ser Gly Val Cys Leu Leu Leu 
545                 550             


<210>  851
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  851
catttatcac ttctcaccac tctgtcaaat aga                                    33


<210>  852
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  852

His Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg 
1               5                   10      


<210>  853
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  853
ggtttttttg cagattatga aattccaaac ctccagaag                              39


<210>  854
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  854

Gly Phe Phe Ala Asp Tyr Glu Ile Pro Asn Leu Gln Lys 
1               5                   10              


<210>  855
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  855
aatgtagtgt acacttgcaa tgaaggatac tctcttattg gaaacccagt ggccaga          57


<210>  856
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  856

Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn Pro 
1               5                   10                  15      


Val Ala Arg 
            


<210>  857
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  857
accttcgtcc tcaacttcat caag                                              24


<210>  858
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  858

Thr Phe Val Leu Asn Phe Ile Lys 
1               5               


<210>  859
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  859
gatattgatg aatgtgacat tgtcccagac gcttgtaaa                              39


<210>  860
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  860

Asp Ile Asp Glu Cys Asp Ile Val Pro Asp Ala Cys Lys 
1               5                   10              


<210>  861
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  861
ggtgtcacct cagtctctca gatcttccac agcccagacc tggccataag g                51


<210>  862
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  862

Gly Val Thr Ser Val Ser Gln Ile Phe His Ser Pro Asp Leu Ala Ile 
1               5                   10                  15      


Arg 
    


<210>  863
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  863
gcactggact ttgccgtcgg cgagtacaac aaa                                    33


<210>  864
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  864

Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys 
1               5                   10      


<210>  865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  865
tacctgactt gggcatcccg g                                                 21


<210>  866
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  866

Tyr Leu Thr Trp Ala Ser Arg 
1               5           


<210>  867
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  867
accattgtga ccacgctgca ggacagcatc cgc                                    33


<210>  868
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  868

Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg 
1               5                   10      


<210>  869
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  869
gctggaacca atggttacat ggctcctgag atcctaatgg aaaag                       45


<210>  870
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  870

Ala Gly Thr Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys 
1               5                   10                  15  


<210>  871
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  871
atcattggct acacacctga tctggaccca gagacagtgg atgatgcctt tgctcgt          57


<210>  872
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  872

Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala 
1               5                   10                  15      


Phe Ala Arg 
            


<210>  873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  873
cttcaggact tgacactccg a                                                 21


<210>  874
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  874

Leu Gln Asp Leu Thr Leu Arg 
1               5           


<210>  875
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  875
gtcttcgacc tggagctgca ccccgcctgc cgc                                    33


<210>  876
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  876

Val Phe Asp Leu Glu Leu His Pro Ala Cys Arg 
1               5                   10      


<210>  877
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  877
gtcggcgcgc acgctggcga gtatggtgcg gaggccctgg agagg                       45


<210>  878
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  878

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
1               5                   10                  15  


<210>  879
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  879
gccttcccgg cccttaccag cctagacctg tctgacaatc ctggactggg cgaacgc          57


<210>  880
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  880

Ala Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu 
1               5                   10                  15      


Gly Glu Arg 
            


<210>  881
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  881
ggctcccttg gtggaggatt tagctcaggg gggttcagtg gtggctcttt tagccgt          57


<210>  882
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  882

Gly Ser Leu Gly Gly Gly Phe Ser Ser Gly Gly Phe Ser Gly Gly Ser 
1               5                   10                  15      


Phe Ser Arg 
            


<210>  883
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  883
atctgcctgg acccagatgc tcccaga                                           27


<210>  884
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  884

Ile Cys Leu Asp Pro Asp Ala Pro Arg 
1               5                   


