				Sequence listing                         


<110>  Johnston, Stephen   A
       Diehnelt, Christopher   W
       Gupta, Nidhi
       Belcher, Paul   E
 
<120>  SYNBODIES TO AKT1

<130>  AzTE M9-085L

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is H or W

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is P or Y

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Q or W

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is H, Y or F

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is N or S

<400>  1

Ala Xaa Lys Val Val Xaa Gln Arg Xaa Xaa Arg Xaa Ala Tyr Xaa Arg 
1               5                   10                  15      


Tyr Gly Ser Gly 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  2

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  3

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210>  4
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  5
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
        195                 200                 205             


His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
        275                 280                 285             


Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
    290                 295                 300                 


Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
305                 310                 315                 320 


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                325                 330                 335     


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
            340                 345                 350         


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
        355                 360                 365             


Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
    370                 375                 380                 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
385                 390                 395                 400 


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                405                 410                 415     


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
            420                 425                 430         


Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
        435                 440                 445             


Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
    450                 455                 460                 


Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
465                 470                 475                 480 


Glu 
    


<210>  6
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  7

Ala His Lys Val Val Pro Gln Arg Gln Met Arg His Ala Tyr Ser Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  8

Ala His Lys Val Val Tyr Gln Arg Gln Ile Arg Phe Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  9

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Lys Cys Ala His Lys Val Val Tyr Gln Arg Gln Ile 
            20                  25                  30          


Arg Phe Ala Tyr Asn Arg Tyr Gly Ser Gly 
        35                  40          


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  10

Ala Trp Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  11
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  11

Ala His Lys Val Val Pro Gln Arg Trp Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  12
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  12

Ala His Lys Val Val Pro Gln Arg Trp Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  13
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  13

Ala Trp Lys Val Val Pro Gln Arg Trp Ile Arg Tyr Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  14
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  14

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  15
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  15

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Lys Cys Ala His Lys Val Val Pro Gln Arg Gln Ile 
            20                  25                  30          


Arg His Ala Tyr Asn Arg Tyr Gly Ser Gly 
        35                  40          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  16

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  17
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  17

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Ala His Lys Val Val Pro Gln Arg Gln Ile 
            20                  25                  30          


Arg His Ala Tyr Asn Arg Tyr Gly Ser Gly 
        35                  40          


<210>  18
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  18

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Lys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  19
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  19

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Lys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  20

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Lys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  21
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with Octanoic acid

<400>  21

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  22
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with Octanoic acid

<400>  22

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  23
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with Octanoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with Octanoic acid

<400>  23

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  24
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with Hexanoic acid

<400>  24

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with Octanoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with Hexanoic acid

<400>  25

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  26
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with (poly-ethylene glycol)n, where (n =1- 8)

<400>  26

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  27
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with (poly-ethylene glycol)n, where (n = 1 - 
       8)

<400>  27

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  28
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with poly-ethylene glycol

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with (poly-ethylene glycol)n, where (n = 1 - 
       8)

<400>  28

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  29
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (21)..(44)
<223>  "Pro Gly Pro" may be present at least 1 and up to 8 times

<400>  29

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Cys Phe Arg 
        35                  40                  45              


Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg Gly Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  30
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (43)..(66)
<223>  "Pro Gly Pro" may be present at least 1 and up to 8 times

<400>  30

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly Pro Gly Pro Pro Gly Pro 
        35                  40                  45              


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
    50                  55                  60                  


Gly Pro 
65      


<210>  31
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (21)..(44)
<223>  "Pro Pro Pro" may be present at least 1 and up to 8 times

<400>  31

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Lys Cys Phe Arg 
        35                  40                  45              


Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg Gly Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  32
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (43)..(66)
<223>  "Pro Pro Pro" may be present at least 1 and up to 8 times

<400>  32

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro 
65      


<210>  33
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with  Beta-Amino Hexanoic Acid

<400>  33

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with  Beta-Amino Hexanoic Acid

<400>  34

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  35
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Synbodies Extended with  Beta-Amino Hexanoic Acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Synbodies Extended with  Beta-Amino Hexanoic Acid

<400>  35

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  36
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(38)
<223>  "Pro Gly Pro" may be present at least 1 and up to 6 times

<400>  36

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Lys Lys Phe Arg Gly Trp Ala His Ile Phe 
        35                  40                  45              


Phe Gly Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
    50                  55                  60  


<210>  37
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(38)
<223>  "Pro Gly Pro" may be present at least 1 and up to 6 times

<400>  37

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Lys Cys Phe Arg Gly Trp Ala His Ile Phe 
        35                  40                  45              


Phe Gly Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
    50                  55                  60  


<210>  38
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(35)
<223>  "Pro Pro Pro" may be present at least 1 and up to 5 times

<400>  38

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Lys Gly Ala Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
        35                  40                  45              


Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
    50                  55              


<210>  39
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(41)
<223>  "Pro Pro Pro" may be present at least 1 and up to 7 times

<400>  39

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Pro Pro Pro Pro Lys Lys Phe Arg Gly Trp Ala 
        35                  40                  45              


His Ile Phe Phe Gly Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
    50                  55                  60              


<210>  40
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(32)
<223>  "Pro Gly Pro" may be present at least 1 and up to 4 times

<400>  40

Ala His Lys Val Val Tyr Gln Arg Gln Ile Arg Phe Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile 
        35                  40                  45              


Tyr Arg Gly Lys Ser Gly 
    50                  


<210>  41
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(26)
<223>  "Pro Pro Pro" may be present at least 1 and up to 2 times

<400>  41

Ala His Lys Val Val Tyr Gln Arg Gln Ile Arg Phe Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Pro Pro Pro Pro Pro Lys Cys Phe Arg Gly Trp 
            20                  25                  30          


Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
        35                  40                  45              


<210>  42
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(26)
<223>  "Pro Pro Pro" may be present at least 1 and up to 2 times

<400>  42

Ala His Lys Val Val Tyr Gln Arg Gln Ile Arg Phe Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Pro Pro Pro Pro Pro Lys Cys Phe Arg Gly Trp 
            20                  25                  30          


Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
        35                  40                  45              

<210>  43
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies


<220>
<221>  MISC_FEATURE
<223>  Synbodies Extended with (PEG)n by Triazole coupling, where (n = 1
       - 7)

<400>  43

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Lys Ser Gly 
        35                  40          


<210>  44
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  44

Ala His Lys Val Val Pro Gln Arg Gln Met Arg His Ala Tyr Ser Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  45
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  45

Ala His Lys Val Val Tyr Gln Arg Gln Ile Arg Phe Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  46

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Lys Cys Ala His Lys Val Val Tyr Gln Arg Gln Ile 
            20                  25                  30          


Arg Phe Ala Tyr Asn Arg Tyr Gly Ser Gly 
        35                  40          


<210>  47
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  47

Ala Trp Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  48
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  48

Ala His Lys Val Val Pro Gln Arg Trp Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  49
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  49

Ala Trp Lys Val Val Pro Gln Arg Trp Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  50
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic antibodies

<400>  50

Ala Trp Lys Val Val Pro Gln Arg Trp Ile Arg Tyr Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Cys Phe Arg Gly Trp Ala His Ile Phe Phe Gly 
            20                  25                  30          


Pro His Val Ile Tyr Arg Gly Gly Ser Gly 
        35                  40          


<210>  51
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  51

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Lys Ser Gly 
            20              


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Lys Ser Gly 
            20  


<210>  53
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  53

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Lys Ser Gly 
            20              


<210>  54
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Gly Ser Gly Tyr Ser Gly 
            20              


<210>  55
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  55

Ala His Lys Val Val Pro Gln Arg Gln Ile Arg His Ala Tyr Asn Arg 
1               5                   10                  15      


Tyr Gly Ser Gly Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  56

Phe Arg Gly Trp Ala His Ile Phe Phe Gly Pro His Val Ile Tyr Arg 
1               5                   10                  15      


Gly Lys Ser Cys 
            20  

 













