
                                SEQUENCE LISTING

<110> Mayo Foundation for Medical Education and Research

<120> METHODS AND MATERIALS FOR MODULATING
  DEUBIQUITINASES AND UBIQUITINATED POLYPEPTIDES
  

<130> 07039/0955WO1

<150> 61/260,637          
<151> 2009-11-12  

<150> 61/241,152          
<151> 2009-09-10  

<160> 13

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3399
<212> DNA
<213> Homo sapiens

<400> 1
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta 60
tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg 120
agtcccaatg aaacgggcag ccatggccct ccacagcccg cagtatattt ttggagattt 180
tagccctgat gaattcaatc aattctttgt gactcctcga tcttcagttg agcttcctcc 240
atacagtgga acagttctgt gtggcacaca ggctgtggat aaactacctg atggacaaga 300
atatcagaga attgagtttg gtgtcgatga agtcattgaa cccagtgaca ctttgccgag 360
aacccccagc tacagtattt caagcacact gaaccctcag gcccctgaat ttattctcgg 420
ttgtacagct tccaaaataa cccctgatgg tatcactaaa gaagcaagct atggctccat 480
cgactgccag tacccaggct ctgccctcgc tttggatgga agttctaatg tggaggcgga 540
agttttggaa aatgatggtg tctcaggtgg tcttggacaa agggagcgta aaaagaagaa 600
aaagcggcca cctggatatt acagctattt gaaagatggt ggcgatgata gtatctccac 660
agaagccctg gtcaatggcc atgccaattc agcagtcccg aacagtgtca gtgcagagga 720
tgcagaattt atgggtgaca tgcccccgtc agttacgccc aggacttgta acagccccca 780
gaactccaca gactctgtca gtgacattgt gcctgacagt cctttccccg gagcactcgg 840
cagtgacacc aggactgcag ggcagccaga ggggggcccc ggggctgatt ttggtcagtc 900
ctgcttccct gcagaggctg gcagagacac cctgtcaagg acagctgggg ctcagccctg 960
cgttggtacc gatactactg aaaaccttgg agttgctaat ggacaaatac ttgaatcctc 1020
gggtgagggc acagctacca acggggtgga gttgcacacc acggaaagca tagacttgga 1080
cccaaccaaa cccgagagtg catcacctcc tgctgacggc acgggctctg catcaggcac 1140
ccttcctgtc agccagccca agtcctgggc cagcctcttt catgattcta agccctcttc 1200
ctcctcgccg gtggcctatg tggaaactaa gtattcccct cccgccatat ctcccctggt 1260
ttctgaaaag caggttgaag tcaaagaagg gcttgttccg gtttcagagg atcctgtagc 1320
cataaagatt gcagagttgc tggagaatgt aaccctaatc cataaaccag tgtcgttgca 1380
accccgtggg ctgatcaata aagggaactg gtgctacatt aatgctacac tgcaggcatt 1440
ggttgcttgc ccgccgatgt accacctgat gaagttcatt cctctgtatt ccaaagtgca 1500
aaggccttgt acgtcaacac ccatgataga cagctttgtt cggctaatga atgagttcac 1560
taatatgcca gtacctccaa aaccccgaca agctcttgga gataaaatcg tgagggatat 1620
tcgccctgga gctgcctttg agcccacata tatttacaga ctcctgacag ttaacaagtc 1680
aagcctgtct gaaaagggtc gacaagaaga tgctgaggaa tacttaggct tcattctaaa 1740
tggacttcat gaggaaatgt tgaacctaaa gaagcttctc tcaccaagta atgaaaaact 1800
tacgatttcc aacggcccca aaaaccactc ggtcaatgaa gaagagcagg aagaacaagg 1860
tgaaggaagc gaggatgaat gggaacaagt gggcccccgg aacaagactt ccgtcacccg 1920
ccaggcggat tttgttcaga ctccaatcac cggcattttt ggtggacaca tcaggtctgt 1980
ggtttaccag cagagttcaa aagaatctgc cactttgcag ccatttttca cgttgcagtt 2040
ggatatccag tcagacaaga tacgcacagt ccaggatgca ctggagagct tggtggcaag 2100
agaatctgtc caaggttata ccacaaaaac caaacaagag gttgagataa gtcgaagagt 2160
gactctggaa aaactccctc ctgtcctcgt gctgcacctg aaacgattcg tttatgagaa 2220
gactggtggg tgccagaagc ttatcaaaaa tattgaatat cctgtggact tggaaattag 2280
taaagaactg ctttctccag gggttaaaaa taagaatttt aaatgccacc gaacctatcg 2340
gctctttgca gtggtctacc atcacggcaa cagtgcgacg ggcggccatt acactacaga 2400
cgtcttccag atcggtctga atggctggct gcgcatcgat gaccagacag tcaaggtgat 2460
caaccagtac caggtggtga aaccaactgc tgaacgcaca gcctacctcc tgtattaccg 2520
ccgagtggac ctgctgtaaa ccctgtgtgc gctgtgtgtg cgcccagtgc ccgcttcgta 2580
ggacaccacc tcacactcac ttcccgcctc tctttagtgg ctctttagag agaaactctt 2640
tctccctttg caaaaatggg ctagaatgaa aaggagatgc cttggggttc gtgcacaaca 2700
cagcttctgt tgactctaac ttccaaatca aaatcatttg gttgaaacag actgttgctt 2760
gattttagaa aatacacaaa aacccatatt tctgaaataa tgctgattcc tgagataaga 2820
aagtggattt gatccccagt ctcattgctt agtagaataa atcctgcacc agcaacaaca 2880
cttgtaaatt tgtgaaaatg aattttatct ttccttaaaa aagaaatttt ttaatccatc 2940
acacttttct tccctaccct ttagtttttg ataaatgata aaaatgagcc agttatcaaa 3000
gaagaactag ttcttacttc aaaagaaaaa taaacataaa aaataagttg ctggttccta 3060
acaggaaaaa ttttaataat tgtactgaga gaaactgctt acgtacacat tgcagatcaa 3120
atatttggag ttaaaatgtt agtctacata gatgggtgat tgtaacttta ttgccattaa 3180
aagatttcaa attgcattca tgcttctgtg tacacataat gaaaaatggg caaataatga 3240
agatctctcc ttcagtctgc tctgtttaat tctgctgtct gctcttctct aatgctgcgt 3300
ccctaattgt acacagttta gtgatatcta ggagtataaa gttgtcgccc atcaataaaa 3360
atcacaaagt tggtttaaaa aaaaaaaaaa aaaaaaaaa                        3399

<210> 2
<211> 798
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp
 1               5                  10                  15      
Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro
            20                  25                  30          
Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu
        35                  40                  45              
Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val
    50                  55                  60                  
Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser
65                  70                  75                  80  
Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala
                85                  90                  95      
Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser
            100                 105                 110         
Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser
        115                 120                 125             
Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu
    130                 135                 140                 
Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr
145                 150                 155                 160 
Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu
                165                 170                 175     
Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu
            180                 185                 190         
Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr
        195                 200                 205             
Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro
    210                 215                 220                 
Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly
225                 230                 235                 240 
Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro
                245                 250                 255     
Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro
            260                 265                 270         
Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln
        275                 280                 285             
Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu
    290                 295                 300                 
His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala
305                 310                 315                 320 
Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val
                325                 330                 335     
Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser
            340                 345                 350         
Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala
        355                 360                 365             
Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu
    370                 375                 380                 
Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu
385                 390                 395                 400 
Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly
                405                 410                 415     
Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala
            420                 425                 430         
Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu
        435                 440                 445             
Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser
    450                 455                 460                 
Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys
465                 470                 475                 480 
Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly
                485                 490                 495     
Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys
            500                 505                 510         
Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu
        515                 520                 525             
Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys
    530                 535                 540                 
Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys
545                 550                 555                 560 
Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser
                565                 570                 575     
Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr
            580                 585                 590         
Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly
        595                 600                 605             
His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr
    610                 615                 620                 
Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile
625                 630                 635                 640 
Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val
                645                 650                 655     
Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg
            660                 665                 670         
Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg
        675                 680                 685             
Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile
    690                 695                 700                 
Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly
705                 710                 715                 720 
Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala
                725                 730                 735     
Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr
            740                 745                 750         
Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln
        755                 760                 765             
Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu
    770                 775                 780                 
Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu
785                 790                 795             


<210> 3
<211> 2586
<212> DNA
<213> Homo sapiens

<400> 3
gattggggtt ttcccctccc atgtgctcaa gactggcgct aaaagttttg agcttctcaa 60
aagtctagag ccaccgtcca gggagcaggt agctgctggg ctccggggac actttgcgtt 120
cgggctggga gcgtgctttc cacgacggtg acacgcttcc ctggattggc agccagactg 180
ccttccgggt cactgccatg gaggagccgc agtcagatcc tagcgtcgag ccccctctga 240
gtcaggaaac attttcagac ctatggaaac tacttcctga aaacaacgtt ctgtccccct 300
tgccgtccca agcaatggat gatttgatgc tgtccccgga cgatattgaa caatggttca 360
ctgaagaccc aggtccagat gaagctccca gaatgccaga ggctgctccc cccgtggccc 420
ctgcaccagc agctcctaca ccggcggccc ctgcaccagc cccctcctgg cccctgtcat 480
cttctgtccc ttcccagaaa acctaccagg gcagctacgg tttccgtctg ggcttcttgc 540
attctgggac agccaagtct gtgacttgca cgtactcccc tgccctcaac aagatgtttt 600
gccaactggc caagacctgc cctgtgcagc tgtgggttga ttccacaccc ccgcccggca 660
cccgcgtccg cgccatggcc atctacaagc agtcacagca catgacggag gttgtgaggc 720
gctgccccca ccatgagcgc tgctcagata gcgatggtct ggcccctcct cagcatctta 780
tccgagtgga aggaaatttg cgtgtggagt atttggatga cagaaacact tttcgacata 840
gtgtggtggt gccctatgag ccgcctgagg ttggctctga ctgtaccacc atccactaca 900
actacatgtg taacagttcc tgcatgggcg gcatgaaccg gaggcccatc ctcaccatca 960
tcacactgga agactccagt ggtaatctac tgggacggaa cagctttgag gtgcgtgttt 1020
gtgcctgtcc tgggagagac cggcgcacag aggaagagaa tctccgcaag aaaggggagc 1080
ctcaccacga gctgccccca gggagcacta agcgagcact gcccaacaac accagctcct 1140
ctccccagcc aaagaagaaa ccactggatg gagaatattt cacccttcag atccgtgggc 1200
gtgagcgctt cgagatgttc cgagagctga atgaggcctt ggaactcaag gatgcccagg 1260
ctgggaagga gccagggggg agcagggctc actccagcca cctgaagtcc aaaaagggtc 1320
agtctacctc ccgccataaa aaactcatgt tcaagacaga agggcctgac tcagactgac 1380
attctccact tcttgttccc cactgacagc ctcccacccc catctctccc tcccctgcca 1440
ttttgggttt tgggtctttg aacccttgct tgcaataggt gtgcgtcaga agcacccagg 1500
acttccattt gctttgtccc ggggctccac tgaacaagtt ggcctgcact ggtgttttgt 1560
tgtggggagg aggatgggga gtaggacata ccagcttaga ttttaaggtt tttactgtga 1620
gggatgtttg ggagatgtaa gaaatgttct tgcagttaag ggttagttta caatcagcca 1680
cattctaggt aggggcccac ttcaccgtac taaccaggga agctgtccct cactgttgaa 1740
ttttctctaa cttcaaggcc catatctgtg aaatgctggc atttgcacct acctcacaga 1800
gtgcattgtg agggttaatg aaataatgta catctggcct tgaaaccacc ttttattaca 1860
tggggtctag aacttgaccc ccttgagggt gcttgttccc tctccctgtt ggtcggtggg 1920
ttggtagttt ctacagttgg gcagctggtt aggtagaggg agttgtcaag tctctgctgg 1980
cccagccaaa ccctgtctga caacctcttg gtgaacctta gtacctaaaa ggaaatctca 2040
ccccatccca caccctggag gatttcatct cttgtatatg atgatctgga tccaccaaga 2100
cttgttttat gctcagggtc aatttctttt ttcttttttt tttttttttt tctttttctt 2160
tgagactggg tctcgctttg ttgcccaggc tggagtggag tggcgtgatc ttggcttact 2220
gcagcctttg cctccccggc tcgagcagtc ctgcctcagc ctccggagta gctgggacca 2280
caggttcatg ccaccatggc cagccaactt ttgcatgttt tgtagagatg gggtctcaca 2340
gtgttgccca ggctggtctc aaactcctgg gctcaggcga tccacctgtc tcagcctccc 2400
agagtgctgg gattacaatt gtgagccacc acgtccagct ggaagggtca acatctttta 2460
cattctgcaa gcacatctgc attttcaccc cacccttccc ctccttctcc ctttttatat 2520
cccattttta tatcgatctc ttattttaca ataaaacttt gctgccacct gtgtgtctga 2580
ggggtg                                                            2586

<210> 4
<211> 393
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
 1               5                  10                  15      
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu
            20                  25                  30          
Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp
        35                  40                  45              
Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
    50                  55                  60                  
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro
65                  70                  75                  80  
Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser
                85                  90                  95      
Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly
            100                 105                 110         
Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro
        115                 120                 125             
Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln
    130                 135                 140                 
Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met
145                 150                 155                 160 
Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
                165                 170                 175     
Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
            180                 185                 190         
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
        195                 200                 205             
Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu
    210                 215                 220                 
Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser
225                 230                 235                 240 
Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr
                245                 250                 255     
Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
            260                 265                 270         
Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn
        275                 280                 285             
Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
    290                 295                 300                 
Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305                 310                 315                 320 
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu
                325                 330                 335     
Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp
            340                 345                 350         
Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His
        355                 360                 365             
Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met
    370                 375                 380                 
Phe Lys Thr Glu Gly Pro Asp Ser Asp
385                 390             


<210> 5
<211> 2586
<212> DNA
<213> Homo sapiens

<400> 5
gattggggtt ttcccctccc atgtgctcaa gactggcgct aaaagttttg agcttctcaa 60
aagtctagag ccaccgtcca gggagcaggt agctgctggg ctccggggac actttgcgtt 120
cgggctggga gcgtgctttc cacgacggtg acacgcttcc ctggattggc agccagactg 180
ccttccgggt cactgccatg gaggagccgc agtcagatcc tagcgtcgag ccccctctga 240
gtcaggaaac attttcagac ctatggaaac tacttcctga aaacaacgtt ctgtccccct 300
tgccgtccca agcaatggat gatttgatgc tgtccccgga cgatattgaa caatggttca 360
ctgaagaccc aggtccagat gaagctccca gaatgccaga ggctgctccc cccgtggccc 420
ctgcaccagc agctcctaca ccggcggccc ctgcaccagc cccctcctgg cccctgtcat 480
cttctgtccc ttcccagaaa acctaccagg gcagctacgg tttccgtctg ggcttcttgc 540
attctgggac agccaagtct gtgacttgca cgtactcccc tgccctcaac aagatgtttt 600
gccaactggc caagacctgc cctgtgcagc tgtgggttga ttccacaccc ccgcccggca 660
cccgcgtccg cgccatggcc atctacaagc agtcacagca catgacggag gttgtgaggc 720
gctgccccca ccatgagcgc tgctcagata gcgatggtct ggcccctcct cagcatctta 780
tccgagtgga aggaaatttg cgtgtggagt atttggatga cagaaacact tttcgacata 840
gtgtggtggt gccctatgag ccgcctcagg ttggctctga ctgtaccacc atccactaca 900
actacatgtg taacagttcc tgcatgggcg gcatgaaccg gaggcccatc ctcaccatca 960
tcacactgga agactccagt ggtaatctac tgggacggaa cagctttgag gtgcgtgttt 1020
gtgcctgtcc tgggagagac cggcgcacag aggaagagaa tctccgcaag aaaggggagc 1080
ctcaccacga gctgccccca gggagcacta agcgagcact gcccaacaac accagctcct 1140
ctccccagcc aaagaagaaa ccactggatg gagaatattt cacccttcag atccgtgggc 1200
gtgagcgctt cgagatgttc cgagagctga atgaggcctt ggaactcaag gatgcccagg 1260
ctgggaagga gccagggggg agcagggctc actccagcca cctgaagtcc aaaaagggtc 1320
agtctacctc ccgccataaa aaactcatgt tcaagacaga agggcctgac tcagactgac 1380
attctccact tcttgttccc cactgacagc ctcccacccc catctctccc tcccctgcca 1440
ttttgggttt tgggtctttg aacccttgct tgcaataggt gtgcgtcaga agcacccagg 1500
acttccattt gctttgtccc ggggctccac tgaacaagtt ggcctgcact ggtgttttgt 1560
tgtggggagg aggatgggga gtaggacata ccagcttaga ttttaaggtt tttactgtga 1620
gggatgtttg ggagatgtaa gaaatgttct tgcagttaag ggttagttta caatcagcca 1680
cattctaggt aggggcccac ttcaccgtac taaccaggga agctgtccct cactgttgaa 1740
ttttctctaa cttcaaggcc catatctgtg aaatgctggc atttgcacct acctcacaga 1800
gtgcattgtg agggttaatg aaataatgta catctggcct tgaaaccacc ttttattaca 1860
tggggtctag aacttgaccc ccttgagggt gcttgttccc tctccctgtt ggtcggtggg 1920
ttggtagttt ctacagttgg gcagctggtt aggtagaggg agttgtcaag tctctgctgg 1980
cccagccaaa ccctgtctga caacctcttg gtgaacctta gtacctaaaa ggaaatctca 2040
ccccatccca caccctggag gatttcatct cttgtatatg atgatctgga tccaccaaga 2100
cttgttttat gctcagggtc aatttctttt ttcttttttt tttttttttt tctttttctt 2160
tgagactggg tctcgctttg ttgcccaggc tggagtggag tggcgtgatc ttggcttact 2220
gcagcctttg cctccccggc tcgagcagtc ctgcctcagc ctccggagta gctgggacca 2280
caggttcatg ccaccatggc cagccaactt ttgcatgttt tgtagagatg gggtctcaca 2340
gtgttgccca ggctggtctc aaactcctgg gctcaggcga tccacctgtc tcagcctccc 2400
agagtgctgg gattacaatt gtgagccacc acgtccagct ggaagggtca acatctttta 2460
cattctgcaa gcacatctgc attttcaccc cacccttccc ctccttctcc ctttttatat 2520
cccattttta tatcgatctc ttattttaca ataaaacttt gctgccacct gtgtgtctga 2580
ggggtg                                                            2586

<210> 6
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
 1               5                  10                  15      
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu
            20                  25                  30          
Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp
        35                  40                  45              
Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
    50                  55                  60                  
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro
65                  70                  75                  80  
Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser
                85                  90                  95      
Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly
            100                 105                 110         
Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro
        115                 120                 125             
Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln
    130                 135                 140                 
Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met
145                 150                 155                 160 
Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
                165                 170                 175     
Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
            180                 185                 190         
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
        195                 200                 205             
Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Gln
    210                 215                 220                 
Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser
225                 230                 235                 240 
Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr
                245                 250                 255     
Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
            260                 265                 270         
Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn
        275                 280                 285             
Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
    290                 295                 300                 
Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305                 310                 315                 320 
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu
                325                 330                 335     
Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp
            340                 345                 350         
Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His
        355                 360                 365             
Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met
    370                 375                 380                 
Phe Lys Thr Glu Gly Pro Asp Ser Asp
385                 390             


<210> 7
<211> 21
<212> DNA
<213> Homo sapiens

<400> 7
gcctctcttt agtggctctt t                                           21

<210> 8
<211> 21
<212> DNA
<213> Homo sapiens

<400> 8
cctatgtgga aactaagtat t                                           21

<210> 9
<211> 21
<212> DNA
<213> Homo sapiens

<400> 9
cccatgatag acagctttgt t                                           21

<210> 10
<211> 21
<212> DNA
<213> Homo sapiens

<400> 10
gctgtggata aactacctga t                                           21

<210> 11
<211> 21
<212> DNA
<213> Homo sapiens

<400> 11
cgacaagctc ttggagataa a                                           21

<210> 12
<211> 19
<212> DNA
<213> Homo sapiens

<400> 12
atgtttcatt cattggaat                                              19

<210> 13
<211> 21
<212> DNA
<213> Homo sapiens

<400> 13
gcctctcttt agtggctctt t                                           21
