                         SEQUENCE LISTING

<110>  Yale University
       Lee, Patty
       Zhang, Xuchen
 
<120>  Toll-like Receptor 4 Deficiency and Downstream Effectors Cause Pulmonary Emphysema

<130>  047162-5035-01-WO (458268)

<150>  US 12/558,308
<151>  2009-09-11

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  397
<212>  PRT
<213>  Mus musculus

<400>  1

Met Lys Pro Leu Leu Val Leu Leu Leu Leu Leu Leu Leu Asp Leu Ala 
1               5                   10                  15      


Gln Ala Gln Gly Ala Leu His Arg Val Pro Leu Arg Arg His Gln Ser 
            20                  25                  30          


Leu Arg Lys Lys Leu Arg Ala Gln Gly Gln Leu Ser Glu Phe Trp Arg 
        35                  40                  45              


Ser His Asn Leu Asp Met Thr Arg Leu Ser Glu Ser Cys Asn Val Tyr 
    50                  55                  60                  


Ser Ser Val Asn Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe 
65                  70                  75                  80  


Gly Thr Ile Ser Ile Gly Thr Pro Pro Gln Asn Phe Thr Val Ile Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser 
            100                 105                 110         


Pro Ala Cys Lys Ala His Pro Val Phe His Pro Ser Gln Ser Asp Thr 
        115                 120                 125             


Tyr Thr Glu Val Gly Asn His Phe Ser Ile Gln Tyr Gly Thr Gly Ser 
    130                 135                 140                 


Leu Thr Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr 
145                 150                 155                 160 


Val Asp Gly Gln Gln Phe Gly Glu Ser Val Lys Glu Pro Gly Gln Thr 
                165                 170                 175     


Phe Val Asn Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser 
            180                 185                 190         


Leu Ala Ala Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln 
        195                 200                 205             


Asn Leu Val Ala Leu Pro Met Phe Ser Val Tyr Leu Ser Ser Asp Pro 
    210                 215                 220                 


Gln Gly Gly Ser Gly Ser Glu Leu Thr Phe Gly Gly Tyr Asp Pro Ser 
225                 230                 235                 240 


His Phe Ser Gly Ser Leu Asn Trp Ile Pro Val Thr Lys Gln Ala Tyr 
                245                 250                 255     


Trp Gln Ile Ala Leu Asp Gly Ile Gln Val Gly Asp Thr Val Met Phe 
            260                 265                 270         


Cys Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile 
        275                 280                 285             


Thr Gly Pro Pro Asp Lys Ile Lys Gln Leu Gln Glu Ala Ile Gly Ala 
    290                 295                 300                 


Thr Pro Ile Asp Gly Glu Tyr Ala Val Asp Cys Ala Thr Leu Asp Thr 
305                 310                 315                 320 


Met Pro Asn Val Thr Phe Leu Ile Asn Glu Val Ser Tyr Thr Leu Asn 
                325                 330                 335     


Pro Thr Asp Tyr Ile Leu Pro Asp Leu Val Glu Gly Met Gln Phe Cys 
            340                 345                 350         


Gly Ser Gly Phe Gln Gly Leu Asp Ile Pro Pro Pro Ala Gly Pro Leu 
        355                 360                 365             


Trp Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp 
    370                 375                 380                 


Arg Gly Asn Asn Gln Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395         


<210>  2
<211>  1804
<212>  DNA
<213>  Mus musculus

<400>  2
gagtgcccct gccctgtgat caagaggaaa gaagggtgga agggagatcg gagcagagtg       60

agagagaagc taccccttgg accacaatga agcccctcct tgtgctgctg ctgctgctgc      120

tcctggatct ggctcaggcc caaggtgctc tgcacagagt gcccctcaga agacatcagt      180

cccttcggaa gaaactacgg gcccaaggac agctctcaga attctggagg tctcataact      240

tggacatgac ccgactcagc gagtcctgta atgtgtattc gagtgtcaat gaacccctca      300

tcaactacct ggatatggaa tactttggca ccatctccat cggcaccccg ccgcagaact      360

tcactgtcat ctttgacacc ggttcatcca acctctgggt cccttctgtg tactgcacca      420

gcccagcatg caaggcacac ccagtattcc atccatcgca gtccgacacg tacacggagg      480

tagggaatca tttctccatc cagtatggta ccgggagcct gacaggaatc attggagctg      540

atcaagtctc tgtggaaggg ttgactgtgg atggccagca gtttggagaa agtgtcaagg      600

agccaggcca gacctttgtg aatgcagagt ttgatgggat tctgggtctg ggatacccct      660

cattggctgc tggaggagtg accccagtgt ttgacaacat gatggcccag aaccttgtgg      720

ctctgcctat gttttctgtc tacttgagca gtgaccctca aggtggctca ggcagtgagc      780

tgactttcgg aggctatgac ccctctcatt tctctgggag cctcaactgg atcccagtca      840

ccaagcaagc ctattggcag attgccctgg atggaatcca ggtgggagac actgtgatgt      900

tctgctccga aggctgccag gccatagtgg acacagggac ctctctcatc actggccccc      960

ccgacaagat caaacagctt caagaggcca ttggggccac acccattgat ggagaatatg     1020

cagtggattg tgccactctc gacacgatgc caaacgttac cttcctcatc aacgaggttt     1080

catataccct caacccaact gactacatcc tgccggactt ggtggaagga atgcagttct     1140

gtggcagtgg ctttcaagga cttgacattc cacctccagc tgggcccctc tggatcctgg     1200

gggatgtctt catccgacag ttctactcag tctttgaccg tggaaataac caagtgggat     1260

tggcccccgc agttccctaa agagggatgt atgcctacat atggatgcct gatacccatt     1320

taacctgtta gatacctttg taactatcaa agccgtcatt tcccatgggg tgtagccacc     1380

ccagagtatt cagaccaatc aaagcataag agtgcacccc actcactgca aacacacaca     1440

cacacacacc acctctacca tcaccacgat gaaagaagtt ctgtctatag tcttcactgc     1500

ttattgttga ctttctatta tggaaatctc taaacatgta cacagtagac atgatggcaa     1560

gataaatacc cacacacctc tgcctcaggt cacaacccat ccatgtgtgg cccagactct     1620

ctatcttcca tccctctggt tccacgcctc tagatttgga agcagattct aagcaccagg     1680

tcattttatc taatgtctaa catccttaca aatcagaatt taaatgtctc accctctcat     1740

aaatgtggac ctgtttttac agttggttta tttgtatcag gattaaaacc agatccataa     1800

ctgg                                                                  1804


<210>  3
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  3
acacgcatac ccacacatac                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  4
tactggagtc actcctccca                                                   20


<210>  5
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  5
gtcgctaaag aagaaaggga aacac                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  6
ttccaagggc atcggtaaac atctg                                             25


<210>  7
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  7
tgccacgacc aagtgacagc aatg                                              24


<210>  8
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  8
agagacggaa atccatcg                                                     18


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  9
cgatgcaacg agtgatgagg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  10
cgcataacca gtgaaacagc                                                   20


<210>  11
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  11
gtcgctaaag aagaaaggga aacac                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  12
ttccaagggc atcggtaaac atctg                                             25


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  13
tcccctctgt gtactgcact                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  14
tactggagtc actcctccca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  15
acacgcatac ccacacatac                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  16
tactggagtc actcctccca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  17
tcccctctgt gtactgcact                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  18
tactggagtc actcctccca                                                   20


<210>  19
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  19
gctagcagtg gatgggccc                                                    19


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  20
atcagccact gagtggagct                                                   20


<210>  21
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  21
gcgcgcuuug uaggauucg                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  22
cgaauccuac aaagcgcgc                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  23
tgtcatctcg ctctggtacg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  24
taacgcgagt gagaatgtgc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  25
gcctacggga tagctgtcaa                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  26
ggactgcaga tgggtgactc                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  27
gtgggccgct ctaggcacca a                                                 21


<210>  28
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  28
ctctttgatg tcacgcacga tttc                                              24


<210>  29
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  29
gcaggacttc caaaagaacg a                                                 21


<210>  30
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  30
gacgaatgcc tgccacaag                                                    19


<210>  31
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  31
gagaccctac cctggactac ca                                                22


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  32
cccagatgag acgccgtact                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  33
cccctccatt cattgcaaga t                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  34
caaaggacgt gccgttcttc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  35
gattgtgccc aagccttcaa                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  36
ctgtcttctt ccatgatgcc c                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  37
catttcgcct ctctgctgat g                                                 21


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  38
ttgatggtgg actgctaggt ttt                                               23


<210>  39
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  39
ccctggaact cacacgaca                                                    19


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  40
ggaaactcac acgccagaag                                                   20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  41
tccctggaat tggcaacaaa g                                                 21


<210>  42
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  42
ggaatttgtt ggcatgactc tcac                                              24


<210>  43
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  43
aaggctgatt tggcaaccat                                                   20


<210>  44
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  44
agcgcttcct ccgaacatt                                                    19


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  45
ccttccataa gctggtggca                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  46
ggcctgttgg cttcttctgt ag                                                22


<210>  47
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  47
cttatcacag ccacaagcat tgaa                                              24


<210>  48
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  48
cacccattca cactgacctc tg                                                22


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  49
ctcgttgcct acgggatagc                                                   20


<210>  50
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  50
ccttcagcat ccttggcct                                                    19


<210>  51
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  51
acaaccaagg gccagaatac tactac                                            26


<210>  52
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  52
ggatgaggct gcagttgagg                                                   20


<210>  53
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  53
tctgatcatg gcactgttct tctc                                              24


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  54
gggattcaag cttcctggtg t                                                 21


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  55
ctgaactcaa ctgtgaaatg cca                                               23


<210>  56
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  56
aaaggtttgg aagcagccct                                                   20


<210>  57
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  57
agttcccaaa tggcctccc                                                    19


<210>  58
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  58
gctacgacgt gggctacagg                                                   20


<210>  59
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  59
agaaaacaat ctgaaacttc cagagat                                           27


<210>  60
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  60
gaagaccaga ggaaattttc aatagg                                            26


<210>  61
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  61
gatcccatac acattacagg actcgttgat atccgcgagt cctgtaatgt gtattttttt       60

ccaac                                                                   65


<210>  62
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  62
tcgagttgga aaaaaataca cattacagga ctcgcggata tcaacgagtc ctgtaatgtg       60

tatgg                                                                   65


<210>  63
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  63
gcacctttga tatgggcaca                                                   20


<210>  64
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  64
gatcccgcac ctttgatatg ggcacaactc gagttgtgcc catatcaaag gtgctttttc       60

caac                                                                    64


<210>  65
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  65
tcgagttgga aaaagcacct ttgatatggg cacaactcga gttgtgccca tatcaaaggt       60

gcgg                                                                    64


<210>  66
<211>  13257
<212>  DNA
<213>  Mus musculus

<400>  66
ctattacaca tagtgtttac tctgggcatg gctattgact ccagacctta tcattgggtc       60

ctcagactgg gcagggcagg tctgggcacc aggaagagcc agtgcccctg ccctgtgatc      120

aagaggagag aagggtggaa gggagatcgg agcagagtga gagagaagct accccttgga      180

ccacaatgaa gcccctcctt gtgctgctgc tgctgctgct cctggatctg gctcaggccc      240

aaggtgctct gcacaggtaa ggccctgtct ccagcactaa gttcaattga ggcatccccc      300

aaccccaacc cagggctgcc ccgggggagg aaagctaatg aggaaatgaa aagaagaaac      360

cgggatctct caggaatccc tagagaagat tccccaggcc tctccttcca gtgtaggtgc      420

ctgcctcagc tcaagggact ccccctctgt tgttcaaagg tgtgctccat agatgtgatt      480

tgtgactcca agccttcaaa tactttccca agggggcctg agcactgcta tccacagggt      540

ccttccatcc ctttaagtca gccctttatg atcagactat agactgtgtc tgacctccca      600

ttccctagaa aatctcaaaa ggccagtgcc caggagggaa agccatttct acccaaattc      660

tgagtctgca agacaaagcc attgctgctt ctggtcttga aggttccctc ctgggtcttg      720

ctgtagtcag gctctgaaca ggtatagagg caatgggagc ctttatttat aaatgcccct      780

ttatttcctg atctttctcc agagtgcccc tcagaagaca tcagtccctt cggaagaaac      840

tacgggccca aggacagctc tcagaattct ggaggtctca taacttggac atgacccgac      900

tcagcgagtc ctgtaatgtg tattcgagtg tcaatgaacc cctcatcaac tacctggatg      960

taagatttct caaattgaag cctgaggaca ctgggtgtag ggaggaaggc tggggccttc     1020

agcaggggcc agtgctgcat tggtggcatt atgatcaggc atggatttgt ttgcttggag     1080

gattcagaca gtcccccagt ctctatctac tctgtaaagc aggcttctaa atgacccagt     1140

atgcagagct ttcttcaaga ggaaagagat aagtatgata tgtgttccaa aaagaaagac     1200

ccctactgtg tgcccagctg ggcattttac tagctattcc tctgggcaaa gaacttggtt     1260

tgccacacct ccaggtccct gatgacatcg tgaggatcag gataatgaga gaaggatgga     1320

cccaagtttc ctgggctatc ctcagtttcc tccctggtgg tccttgctct gttccttcca     1380

tcctttgcct ccagccttgc ctcttctggg ctctgtagat tgtagcttgt ggtacttcat     1440

gatttagtgc ccttcccctc cactccaccc acacactctc tctctctctc ttccctacag     1500

atggaatact ttggcaccat ctccatcggc accccgccgc agaacttcac tgtcatcttt     1560

gacaccggtt catccaacct ctgggtccct tctgtgtact gcaccagccc agcatgcagt     1620

aagtgaactt ggcagtggcg ggagctcact aggctaagat ggtaccttgt ggcatagaga     1680

gactcaggtt ctctccactt atcttccctg ccatactggc ttccccttcc tatatctgtt     1740

tgttgtgcct gagccaagca cagacaagaa aggcaactac cagttaagat aacaaccttc     1800

atgttcatta gaattgatgg agagaaaatt agccattagg acgtggtgac tcacttcctt     1860

tggaacaccc aaaggaacat gggggaaagt tccttcggtc tgtacctgaa ccgatagcta     1920

gattgaattc taaggaaaac tgtgctcctg ctccagggag gccctgatgc actggctccc     1980

ttggaggtgt ggctcgtggg acacagtggt gtaggtgtgt ccatttgacc agaggtaatg     2040

taggggctac atagagatta gaaacagaca ccctaaacag agaaagcttg ttctgtgtgg     2100

gacacatctc aaggacagaa gctctttgaa actctgacaa cagacattgt caaggtcagg     2160

tgaggaggta ggagtgattt cttagagtag taattgaaac tcggtgtggg tcgggcccac     2220

actgatggct gaggctgctg ctggcgcctg gtggacggtg cttatcttgt gtctatgaag     2280

tcactgtgac taaccaggtt tgtccaggga caaatatttg gcccctggct agaacacacc     2340

tgtggctagg gaacacagcc atggtatgcc tgtctaggaa gccccatctt caacctagtg     2400

tggggagcag aggggagcca ctccaccccc ctgggatggg gtggaagact caagcagcat     2460

tcttgctttc cagaggcaca cccagtattc catccatcgc agtccgacac atacacggag     2520

gtagggaatc atttctccat ccagtatggt accgggagcc tgacaggaat cattggagct     2580

gatcaagtct ctgtgagtac aatgcccaca tcttgcccca gaactaggcc tggggatagc     2640

aggatatgat tcaaagcctc aggggcacag tttcagctct gccttgggac gagaagacaa     2700

ggttatttct agcacaaggg aacagctcgt tctacctgag atagcccggt ggccatcttt     2760

gcaggatgct gaacctagag agcagtgtgg ggcttccttc agggaacaag ggtcagtcag     2820

ggcatgatgc cttgtgtcag ggctggatca ggaaaccctg ggaactgagg ggataagaac     2880

aggctgccat cttgaaagaa aaaagatgtt gaagcccgta gacaggctgg ggctccatta     2940

gtggagtggg aaggcaggag gcaggaatcc aagacaggga agaagccagg tatcaaagcc     3000

ccaagttcct tgaacttctc atggccagag gtcccgaatg tccctgattt gtaggaatca     3060

gagagtcagg agggccctgg tcctgcctgg atactttatg caagtgtata gtcccagggc     3120

ttggtagaaa tagagaatgg gccacccgga tgggtgagta ttattctcga tctagcctga     3180

tccaaaggcc agcaaagctt agtcttcatc agcatctctt ccaaactttg aacatgggat     3240

atatgattaa ctgaaaaagg gctgctaaca gaaatctctc ttttcttctc tgtccccctc     3300

ctcacattaa acctggtgca tatctttctg ggcccttatg acgtgtgtgg ggtcggagta     3360

ctgtagtgag ctggtcatca aatagtataa agcaaagcaa atatgtcaat ggccttaatt     3420

attctcttta gggtagtagg tctccttaaa atatgtctaa gtgggttgga tagatggctc     3480

agtggttaag agcacagact gctcttccaa aagaccccgg ttcaatcccc agtacccaat     3540

gtcagctcgt atctgtctgt agctccagtc ccagcagagc caggactcag acacaagtgc     3600

aggaaaacac caatgcaaag aaagagaagc caatacaaga aaaagaaatc actaaagaca     3660

atttaaaaaa acaatttaag taaagccagc tatggtggca cacaccttta atcccagaac     3720

ttagaaagct gcagccaatg gatctctgag ttcgaggcca gcctagccta catagagagt     3780

tccaggccag ctaaggacta catagtgaaa ccctgtctcc aaacttgaaa aaagtttcag     3840

taatgtcttc ttatcataaa aatgcttttt atgtaaaatt atataaatga agcagagcta     3900

tcagttgaaa ttttacatgc atatgtaaat acacattatg tgtatatgtt acagtataaa     3960

taaccacttg gaaggctgca tgtcaacctg atcattgtag aaagtctgga gagcagggag     4020

gagactgaga tctacaggag gtgggctctg gcatacagct tctcgcctct ctgctagttg     4080

ccctgaacag agcagagagc agccaagccc atagcaactt cagctgcaat ggcctctcct     4140

tcagcacttc tggctctggg gcaggtgccc atttgcctct gtggcagtgt tagcttctac     4200

tgtgaagcat tccttcactg aatatagagg acatcatggt gccagtccat ccctacaggc     4260

tgcagctggc atctttccca cttggcacgt agcttccctc tgctgctgct tctgtagacc     4320

tcaggctgca accctaggtt agcaaccaca tcctaagtgc actcccagct ggcatctgca     4380

atggtataaa gccaagtacc taacacatat atagcatata agcacacaga ttagtacagt     4440

tcatgcagcc tgaaatgtaa agatcagaaa atcagtgatc taagccgcgg tttggagtaa     4500

caaacactaa gaaacaagct gttaataaac aggcgcaagc caaacccaag ggaaagaaat     4560

cacatagaga aggacagggc atcggtacaa taggaaatcc acactataaa catacagcca     4620

ggcgtggtgg cgcacacctt taattccagc acttgggagg tagaggcaga ggcaggcaga     4680

tttctgagtt cgaggccagc ctggtctaca aagtgagttc caggacagcc aggactacaa     4740

agagaaaccc tgtctcaaaa aacatacaaa caaaaaaaca aaacaaaaaa atcaactacg     4800

tcacagatta actgtttgca aagagcaacc aaattggtaa ccctctggca taactaatcc     4860

agaaaaatga aggaaataca atgaccttgt caatctcaaa acaagatgtc aaaaaatgct     4920

tgatattgat acactacaat aattttaaat agatgactat caaaactgat acaataaaat     4980

agaaatgatt aataatctgg tatctatttt aagtggtgat tctgctatta aaacaacaac     5040

aaaacaaaac aaaaaaccca cttcccacaa ggaagtgaca gatccatctt ccagagaatt     5100

gatagaattc cttcataact tcaccagaac aactatgata acaaaatgtg aaaagattct     5160

tatacacact gagacttgct agacatagtg gcacaggcct ttaatccctg tactcagggg     5220

gcagaggcag gcagacctct atgaatgtca ggccagtctg gtccacatag agaattttag     5280

gactgccaag actatgtagt gagaccatgt ctcaaccagt cgcccagtgc agtgagcaga     5340

gtgcttgtct agtgtacgca aagcccagaa ttgcatcccc aggaccacat aaactggaca     5400

aggtgataca tatgtataat cccagcaccc aggaggcaga ggcaagaggg tcagaagttg     5460

aagatttcct ccattgcata gtatgctcag tgctagcctg ggctatatga gatcctgtag     5520

gaatatgtaa tgtgttcacc agaggaagtg ccagtgcacc attattgata atcaaatatt     5580

ggaaacagcc cagctatcca cccatagtat aaggcagtgt ttctcaacct gtgggtagca     5640

acctctttgg atcaatttgt aacaatgaaa atataagcca cacacacaca cacacacaca     5700

cacacacaca cacacacatt atatatatac atatataatg taatatatgt gtgtgtattt     5760

acattatgat ccacaatagt agcaaaatta cagttacaaa gtagcagcga aaatgtcatg     5820

gcgggtggtc atcacaacat gagaaactgt attaaaggtt gccccagtag taggaaggct     5880

gatgacccca aaaataggca aaaccaatgt tgcttgagag atgagtcact cttgagggat     5940

acaaagactg gcagggtata tgaaaggcct gctggggctt cggattgtcc tgtcttattt     6000

cagaagggtt acataagaat gtggactgtt attaaaaaat agacactcat gttttctgca     6060

ttacattata ttttgatttt taaagtcaca tgaagaaagt ccaagagtgg gattatagtg     6120

aaaatctgtg tgcctatttc cccaggaggc tgagaaagga agatctagct tcacccggga     6180

atctgagacc ctccttcaac taacctttgt gtaattctcc cttcaggtgg aagggttgac     6240

tgtggatggc cagcagtttg gagaaagtgt caaggagcca ggccagacct ttgtgaatgc     6300

agagtttgat gggattctgg gtctgggata cccctcattg gctgctggag gagtgacccc     6360

agtgtttgac aacatgatgg cccagaacct tgtggctctg cctatgtttt ctgtctactt     6420

gagcaggtga ggccagtcaa gtcactgagg tccaatcagt gaatgactac aggcagatgg     6480

cctggtacat aagacttcaa ggttctgagg cccatgaatc tctcgaatct cttccttggc     6540

ctatgatgta tatgatcttg agaaaaaaaa aacaaaaaca aaaacaaaaa caaaaaaacc     6600

ctgaagcgat ttggatttca aggaaatggg gtttgactca taaaagagtt gagttgagca     6660

ctttacaatc tagcacggtg agttaaagtt atagaccgtt gcgattggct agtgatttat     6720

ttggtcatta aattctaaag tccttttata tgctaagtgt gacagtagac accaaaacac     6780

aaggaaacaa gagtagtctc cgtggttggg agagaaggaa aagattaacc agcaagatga     6840

tactaaaagt aacttctaca ttagggcgag gaaaggaaac tgtagtatag ccatgtagta     6900

gaatatcact tggtctctgg aaggaaaacc agtgagggat gcagtgtgca gtagaggact     6960

tacctagctg acacaaggct ccgggttcac tctccaatgc ctcacagaca tgtgctagaa     7020

catggattat gctaaatgaa ctaagccagt agcccaaagg acagatacaa attatacttt     7080

atgcgaggta cctagaactg aattcatagg cgaaaagtgc agtggtggtt gcgacggggt     7140

agagggataa ataggaaggg ggttctcgct taatgagtct cagttctaca ctgtgaaaat     7200

gttctggaga acagcttccc aggaatgaaa ttctgaagtg cacactcaaa aaatggttaa     7260

gcttgttcta tcttatggct gtactgccac gagttttaaa gatgcacaca ctacagttaa     7320

aaagagcatg gagctcaccg ctctagcctg gggtgctgag gaagtcactt tcctacctac     7380

acagaaagat ttacctttcc cactctggcc tggcctggcc tgagctcgcc acattccagt     7440

gtaagtcccc tttccctgtc cccctcccac atcagaagtt cctggagtga gtggctgcag     7500

ctgggaccag gcctgggtag ggttttgatt gagcccctgc tgtcagaact cctgtttcct     7560

ctgcagaggc tcctgaacta cctgctaaag aagtgtgcag ctttggtcag tagcaaggcc     7620

agcatagcct ggaactaagt ctgcatgttt gtctcccagg gcctagggtt cctcaggcaa     7680

atgtgaggct gctgtgagaa ttcaacaaga tcgggtggag tgagaatttt ggtttcttca     7740

aagacagaaa tgtcagcgga atctgttttc attttaatcc ctggtgtggc atatggggct     7800

gctttagatt gtccacagca gccaactatg atttacccaa tgcatgctct agagggggca     7860

tgattttgcc agctgcagat aggttctgca ggtatatgat gtttgaaagt ctggagactc     7920

ttgagagggt atagaagctg ctgctggtgg tggttgctgc tgatgcggtt tgtcaagtag     7980

tcacgcacaa agggtcacaa gaaggaaaaa ttagatagcc tgattgctaa gatcgaactt     8040

gtcccaagga actctatgcc cctaatcagc aggaagtaat ctaacaatat cattgacccc     8100

tttcctctca accttctttc tctctaccta gttcttaggg tgggggcaaa tggaagggtg     8160

aaataggggt gaagaagagt ggcaggaaaa agaacctata aagtagccaa aagttggctt     8220

actgtcatgt ggttagattg ctagaacccg gcaagcaagt gttctacccc ttagctatgt     8280

cctcagtccc caataaacct gaaattctct actgacatat acttccttcc ctactgctac     8340

tctatcctgc agcaccccag gcttagactc tttcctcctg gaaatgccct cctttccaga     8400

atcctcctaa atcccagcat aaaacttgag aaataactac caaggaaaat tagccgatag     8460

taaagcccca gtaagacatg ttgctttcaa atgatctttt ctgaagaagt ggatacggta     8520

gaaaccccag acaccacagc atcaatagca gggaagatac tgtgagaaag agtattttgg     8580

gggcatcctc agttgcacag tgtttgtacc caacacccaa gatagtcctg accttagatc     8640

tagagttcag atactcccta cctcctgaac tttttatcta agaagcaggg gatatgcaca     8700

gggtgttaga cagagttgtt cctatctttg atccccaaag acgcaggcta cctaggtagt     8760

ttctgcctac tttgccacca gatgtgagtg cccggacatg caacaaaggg gccctgaact     8820

cctgtctgtg tttccagagg ccatttcttg acaacctgcc tttctctctg catagtgacc     8880

ctcaaggtgg ctcaggcagt gagctgactt tcggaggcta tgacccctct catttctctg     8940

ggagcctcaa ctggatccca gtcaccaagc aagcctattg gcagattgcc ctggatgggt     9000

gagtatcctc tagatagtag ctatggttga atggaagagt ggccacaact caaactggat     9060

taactgggtg atgctgcagg acactagaac agatgctggg agcctcacat ctggactgga     9120

gatgtgaaaa cacacaggaa ggacaagagg ggcagcttcc ttctgtgtac atttagctgg     9180

cctccctctg actcacacaa ccagctatcc tgtcttcaag cagccttaat tgatacacaa     9240

ggcaagggct gagcaccagg gaaaagacac tggctagctg aactcaaagc ctgtatggaa     9300

tatgaggtgt ggtcccaaat caccaccaca caaaatggat gtggtcagtg ttctgaaagc     9360

caccggtatg gccagccaac agcacaagat gtctctgtct gaagactgct catgttttgt     9420

ggaggcaatg actctggaac tgagccttga aagccatgcc tgggcatgaa gcaaatgggg     9480

aagcagcatt gcgtacctga tagatatatg gccagccccg tgctagttaa ggggacagtt     9540

taaggagaac aatctagttt ctgttcctca gatgatctgg ataaaaagtg aaagttccaa     9600

ctctttgtag ctcctgacgc ttttccgact gagatttacc tatttatgct catgagatcg     9660

ttttaaggaa tctcggtccg tttgcttggt tttatttttt gaggcaggat cttcccatgt     9720

agccccagct gtcctagaac gctcaggatc ctgtcagcct cctgcatgct ggagttacag     9780

gtgtccccac catgcccagc tctccatctg catttctgaa taaaaacaga gcacagtaga     9840

aaattcaaga atgtatttca gtgtgtgtgt gttcatgtgc tcgtgcatac ttgatcatga     9900

attaaatgta ttcctgccct aaatctcagt caaaaaagca agttgagtca agtataatgg     9960

ctcatgccta taattccagc atccatgagg actgctatgg gtttgagatt agcctggaca    10020

ggatgaagat gtcttaaaaa gaagcaagtt ggccaggcat agtggtgcat gcctttaatc    10080

ccagcacctg ggagacaaag gcaggtggat ctctgaattc aaggccagtc tatatagtga    10140

gttctagaac caccaaagcg atgcagagag accctatctc aaacaaacaa atatgctagt    10200

tgaaataagc tactactcct gtggtagaag agaccaaaga gaacaccatt attgtgacct    10260

aatatagtaa agggccccag agagagagag agagagagag agagagagag agagagagag    10320

agagagagag agagagcagg aatggccaag gatcatgtgt taaccatggg accatgggac    10380

tctttgtcct cagaatccag gtgggagaca ctgtgatgtt ctgctccgaa ggctgccagg    10440

ccatagtgga cacagggacc tctctcatca ctggcccccc cgacaagatc aaacagcttc    10500

aagaggccat tggggccaca cccattgatg gagaagtgag tgtctaccga gggtggagga    10560

tggtagagga gcaggagatc ctgtccttgt ctggggagag agtgggggtc tgagttgatc    10620

cttctctgtt ttagtatgca gtggattgtg ccactctcga cacgatgcca aacgttacct    10680

tcctcatcaa cgaggtttca tataccctca acccaactga ctacatcctg ccggtaaggg    10740

ctgtttcctt attctgtgag tcacagtacc ctccccacgt gcacctgcca cttccccctt    10800

caaagtcatc tacatgaggc taccactctt ccaaggctcc tcccagctag tccaggggat    10860

gcctatgtgg cattctctct gaaagagatg aagctgcctg cggtagaaac tcctggactt    10920

ctagtttcca gttctgctat gaagcagcag ctactcaggt acaagacact taagggggat    10980

ttctgatatt gccatgagga atttatcaac aaacacatta atcctcccca ctaccggtgt    11040

gcaactggag atgttattat cctattatac atgggaggaa gctaaggtcc tcagagttaa    11100

ataaatgctt cagatctgac tgctggggtt ggagagatgg ctcagcagtt aagagcactt    11160

ggatgctcca ggggaccaca attgagttct gcacctgcat gtatggctca caaaccatat    11220

gtaactccag ctccaggaaa tcaaatgccc tcttctgatc tctgtgggac cccctcatgc    11280

atgtgcacag atattgcaca catacacata aacgtttttt ttaagattta tgaatttatt    11340

ttatttatgt aagcacactg tagctgtctt cagacacacc agaagagggc atcatgtctt    11400

actacatggt tgtgaactac catgtggttg ctgggaattg aactcaggac ctctggaaga    11460

gcagtcagtg ctcttaaccc ctgagccatc tctacagctc cccacacaaa aatttttaaa    11520

gagtgacttt aaaatagata atgagctgct taaggagggg ccaccattca aattaccttt    11580

cttcaaggta aaattcgtct tttattgaaa tgattcccaa gttctgaggg tgaggtggag    11640

gtgaaagtct ggacattttg gaaacctcag gtcatttccc atcccccagg gcctaggttt    11700

tgatgttgtg ctcctttggc aacacacttt aatgtgttga tctttaagca cagtccccta    11760

taacatcagg atctgtgtca gcatcaagat gccaaggtag aaggtgacct tcaccttatc    11820

cttcccaaag ccacccgatg taaacagaca tccaaacaaa cacaagcact tgctccaagg    11880

catagtttca tggtaaagca ctcaagctct agggacagtc tggaacagcc tctgcagaca    11940

ccatgttgag cacataccac tgttgaaact gagccctgct ctcactctca gtctctttgc    12000

catgctactt tggaccctag gacttaagtt actaagtctt agtagtcaga atgcagttct    12060

gcagcagagg ctctcaagga catgacatca ccctccagct gtgccccctc tgggattctg    12120

ggggatgccc agctccttta ctctcctact tttatccaac aagaggctct gctggtaacc    12180

acaccccggc cctacctgcc aggttttaat cagggatctc aacccataaa ggatgctggg    12240

atagctttaa attgtatccc agtcctctca caaggctgtg gctttcccac ctcttcatca    12300

gcaactttga gtgtcagatg ttgggaaggc cacacctgct gatagaactc aaatctttgc    12360

taaactgaaa aataagactg aaagacagga gtggcggtga atgtctacca tcccagtgga    12420

gcagaggcag gaaagggagt tctaggcaac agaggttaca gaatgtctca aaaaaaaaaa    12480

aaaaaaagat tgggggagtt tacagtctct tcatagaaca atggatttgt gcttgccttg    12540

tgtctcagag agcccactca aatgcttctt ccccagatgt gaagaaggaa gtggtagtag    12600

ctagccattt atagaacaga tattaagtca agctccgctt aaaactaaac cagattgggt    12660

ttaaaccaat gcgctctaac gccaaacctt ctgcagtaag gttctgtttc cacgtttcca    12720

gttatgaact gatggtagag tatggccgta aaaacataca gttctcagaa ttgtagaaca    12780

cccataatga agggagcaag cataccctgt actgagcaag ctggaatagg agcaggaaat    12840

gagagaaagc cctccaacca caaccgtggc actcagcaac catccaaggc cattgcacgg    12900

ccagcaccac caacagtaca gctcccagga ctacatccat tgtcccctgt ctgtttcttt    12960

tgtgccctag gacttggtgg aaggaatgca gttctgtggc agtggctttc aaggacttga    13020

cattccacct ccagctgggc ccctctggat cctgggggat gtcttcatcc gacagttcta    13080

ctcagtcttt gaccgtggaa ataaccaagt gggattggcc cccgcagttc cctaaagagg    13140

gatgtatgcc tacatatgga tgcctgatac ccatttaacc tgttagatac ctttgtaact    13200

atcaaagccg tcatttccca tggggtgtag ccaccccaga gtattcagac caatcaa       13257


<210>  67
<211>  156
<212>  DNA
<213>  Mus musculus

<400>  67
agtgcccctg ccctgtgatc aagaggagag aagggtggaa gggagatcgg agcagagtga       60

gagagaagct accccttgga ccacaatgaa gcccctcctt gtgctgctgc tgctgctgct      120

cctggatctg gctcaggccc aaggtgctct gcacag                                156


<210>  68
<211>  159
<212>  DNA
<213>  Mus musculus

<400>  68
agagtgcccc tcagaagaca tcagtccctt cggaagaaac tacgggccca aggacagctc       60

tcagaattct ggaggtctca taacttggac atgacccgac tcagcgagtc ctgtaatgtg      120

tattcgagtg tcaatgaacc cctcatcaac tacctggat                             159


<210>  69
<211>  118
<212>  DNA
<213>  Mus musculus

<400>  69
atggaatact ttggcaccat ctccatcggc accccgccgc agaacttcac tgtcatcttt       60

gacaccggtt catccaacct ctgggtccct tctgtgtact gcaccagccc agcatgca        118


<210>  70
<211>  119
<212>  DNA
<213>  Mus musculus

<400>  70
aggcacaccc agtattccat ccatcgcagt ccgacacata cacggaggta gggaatcatt       60

tctccatcca gtatggtacc gggagcctga caggaatcat tggagctgat caagtctct       119


<210>  71
<211>  200
<212>  DNA
<213>  Mus musculus

<400>  71
gtggaagggt tgactgtgga tggccagcag tttggagaaa gtgtcaagga gccaggccag       60

acctttgtga atgcagagtt tgatgggatt ctgggtctgg gatacccctc attggctgct      120

ggaggagtga ccccagtgtt tgacaacatg atggcccaga accttgtggc tctgcctatg      180

ttttctgtct acttgagcag                                                  200


<210>  72
<211>  123
<212>  DNA
<213>  Mus musculus

<400>  72
tgaccctcaa ggtggctcag gcagtgagct gactttcgga ggctatgacc cctctcattt       60

ctctgggagc ctcaactgga tcccagtcac caagcaagcc tattggcaga ttgccctgga      120

tgg                                                                    123


<210>  73
<211>  142
<212>  DNA
<213>  Mus musculus

<400>  73
aatccaggtg ggagacactg tgatgttctg ctccgaaggc tgccaggcca tagtggacac       60

agggacctct ctcatcactg gcccccccga caagatcaaa cagcttcaag aggccattgg      120

ggccacaccc attgatggag aa                                               142


<210>  74
<211>  99
<212>  DNA
<213>  Mus musculus

<400>  74
tatgcagtgg attgtgccac tctcgacacg atgccaaacg ttaccttcct catcaacgag       60

gtttcatata ccctcaaccc aactgactac atcctgccg                              99


<210>  75
<211>  187
<212>  DNA
<213>  Mus musculus

<400>  75
gacttggtgg aaggaatgca gttctgtggc agtggctttc aaggacttga cattccacct       60

ccagctgggc ccctctggat cctgggggat gtcttcatcc gacagttcta ctcagtcttt      120

gaccgtggaa ataaccaagt gggattggcc cccgcagttc cctaaagagg gatgtatgcc      180

tacatat                                                                187


<210>  76
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Gly Cys Trp Ile Leu Asn Glu Gly Leu Ser Thr Ile Leu Val 
1               5                   10                  15      


Leu Ser Trp Leu Gly Ile Asn Phe Tyr Leu Phe Ile Asp Thr Phe Tyr 
            20                  25                  30          


Trp Tyr Glu Glu Glu Glu Ser Phe His Tyr Thr Arg Val Ile Leu Gly 
        35                  40                  45              


Ser Thr Leu Ala Trp Ala Arg Ala Ser Ala Leu Cys Leu Asn Phe Asn 
    50                  55                  60                  


Cys Met Leu Ile Leu Ile Pro Val Ser Arg Asn Leu Ile Ser Phe Ile 
65                  70                  75                  80  


Arg Gly Thr Ser Ile Cys Cys Arg Gly Pro Trp Arg Arg Gln Leu Asp 
                85                  90                  95      


Lys Asn Leu Arg Phe His Lys Leu Val Ala Tyr Gly Ile Ala Val Asn 
            100                 105                 110         


Ala Thr Ile His Ile Val Ala His Phe Phe Asn Leu Glu Arg Tyr His 
        115                 120                 125             


Trp Ser Gln Ser Glu Glu Ala Gln Gly Leu Leu Ala Ala Leu Ser Lys 
    130                 135                 140                 


Leu Gly Asn Thr Pro Asn Glu Ser Tyr Leu Asn Pro Val Arg Thr Phe 
145                 150                 155                 160 


Pro Thr Asn Thr Thr Thr Glu Leu Leu Arg Thr Ile Ala Gly Val Thr 
                165                 170                 175     


Gly Leu Val Ile Ser Leu Ala Leu Val Leu Ile Met Thr Ser Ser Thr 
            180                 185                 190         


Glu Phe Ile Arg Gln Ala Ser Tyr Glu Leu Phe Trp Tyr Thr His His 
        195                 200                 205             


Val Phe Ile Val Phe Phe Leu Ser Leu Ala Ile His Gly Thr Gly Arg 
    210                 215                 220                 


Ile Val Arg Gly Gln Thr Gln Asp Ser Leu Ser Leu His Asn Ile Thr 
225                 230                 235                 240 


Phe Cys Arg Asp Arg Tyr Ala Glu Trp Gln Thr Val Ala Gln Cys Pro 
                245                 250                 255     


Val Pro Gln Phe Ser Gly Lys Glu Pro Ser Ala Trp Lys Trp Ile Leu 
            260                 265                 270         


Gly Pro Val Val Leu Tyr Ala Cys Glu Arg Ile Ile Arg Phe Trp Arg 
        275                 280                 285             


Phe Gln Gln Glu Val Val Ile Thr Lys Val Val Ser His Pro Ser Gly 
    290                 295                 300                 


Val Leu Glu Leu His Met Lys Lys Arg Gly Phe Lys Met Ala Pro Gly 
305                 310                 315                 320 


Gln Tyr Ile Leu Val Gln Cys Pro Ala Ile Ser Ser Leu Glu Trp His 
                325                 330                 335     


Pro Phe Thr Leu Thr Ser Ala Pro Gln Glu Asp Phe Phe Ser Val His 
            340                 345                 350         


Ile Arg Ala Ala Gly Asp Trp Thr Ala Ala Leu Leu Glu Ala Phe Gly 
        355                 360                 365             


Ala Glu Gly Gln Ala Leu Gln Glu Pro Trp Ser Leu Pro Arg Leu Ala 
    370                 375                 380                 


Val Asp Gly Pro Phe Gly Thr Ala Leu Thr Asp Val Phe His Tyr Pro 
385                 390                 395                 400 


Val Cys Val Cys Val Ala Ala Gly Ile Gly Val Thr Pro Phe Ala Ala 
                405                 410                 415     


Leu Leu Lys Ser Ile Trp Tyr Lys Cys Ser Glu Ala Gln Thr Pro Leu 
            420                 425                 430         


Lys Leu Ser Lys Val Tyr Phe Tyr Trp Ile Cys Arg Asp Ala Arg Ala 
        435                 440                 445             


Phe Glu Trp Phe Ala Asp Leu Leu Leu Ser Leu Glu Thr Arg Met Ser 
    450                 455                 460                 


Glu Gln Gly Lys Thr His Phe Leu Ser Tyr His Ile Phe Leu Thr Gly 
465                 470                 475                 480 


Trp Asp Glu Asn Gln Ala Leu His Ile Ala Leu His Trp Asp Glu Asn 
                485                 490                 495     


Thr Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Phe Tyr Gly Arg Pro 
            500                 505                 510         


Asn Trp Asn Asn Glu Phe Lys Gln Ile Ala Tyr Asn His Pro Ser Ser 
        515                 520                 525             


Ser Ile Gly Val Phe Phe Cys Gly Pro Lys Ala Leu Ser Arg Thr Leu 
    530                 535                 540                 


Gln Lys Met Cys His Leu Tyr Ser Ser Ala Asp Pro Arg Gly Val His 
545                 550                 555                 560 


Phe Tyr Tyr Asn Lys Glu Ser Phe 
                565             


