                         SEQUENCE LISTING

<110>  Max-Delbrck-Centrum (MDC) fr molekulare Medizin 
       Berlin-Buch
 
<120>  Use of ARC for Inhibiting Cell Death During Liver Failure

<130>  MDC003WO

<150>  EP09011758
<151>  2009-09-15

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggcaacg cgcaggagcg gccgtcagag actatcgacc gcgagcggaa acgcctggtc       60

gagacgctgc aggcggactc gggactgctg ttggacgcgc tgctggcgcg gggcgtgctc      120

accgggccag agtacgaggc attggatgca ctgcctgatg ccgagcgcag ggtgcgccgc      180

ctactgctgc tggtgcaggg caagggcgag gccgcctgcc aggagctgct acgctgtgcc      240

cagcgtaccg cgggcgcgcc ggaccccgct tgggactggc agcacgtggg tccgggctac      300

cgggaccgca gctatgaccc tccatgccca ggccactgga cgccggaggc acccggctcg      360

gggaccacat gccccgggtt gcccagagct tcagaccctg acgaggccgg gggccctgag      420

ggctccgagg cggtgcaatc cgggaccccg gaggagccag agccagagct ggaagctgag      480

gcctctaaag aggctgaacc ggagccggag ccagagccag agctggaacc cgaggctgaa      540

gcagaaccag agccggaact ggagccagaa ccggacccag agcccgagcc cgacttcgag      600

gaaagggacg agtccgaaga ttcctga                                          627


<210>  2
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn Ala Gln Glu Arg Pro Ser Glu Thr Ile Asp Arg Glu Arg 
1               5                   10                  15      


Lys Arg Leu Val Glu Thr Leu Gln Ala Asp Ser Gly Leu Leu Leu Asp 
            20                  25                  30          


Ala Leu Leu Ala Arg Gly Val Leu Thr Gly Pro Glu Tyr Glu Ala Leu 
        35                  40                  45              


Asp Ala Leu Pro Asp Ala Glu Arg Arg Val Arg Arg Leu Leu Leu Leu 
    50                  55                  60                  


Val Gln Gly Lys Gly Glu Ala Ala Cys Gln Glu Leu Leu Arg Cys Ala 
65                  70                  75                  80  


Gln Arg Thr Ala Gly Ala Pro Asp Pro Ala Trp Asp Trp Gln His Val 
                85                  90                  95      


Gly Pro Gly Tyr Arg Asp Arg Ser Tyr Asp Pro Pro Cys Pro Gly His 
            100                 105                 110         


Trp Thr Pro Glu Ala Pro Gly Ser Gly Thr Thr Cys Pro Gly Leu Pro 
        115                 120                 125             


Arg Ala Ser Asp Pro Asp Glu Ala Gly Gly Pro Glu Gly Ser Glu Ala 
    130                 135                 140                 


Val Gln Ser Gly Thr Pro Glu Glu Pro Glu Pro Glu Leu Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Lys Glu Ala Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu 
                165                 170                 175     


Pro Glu Ala Glu Ala Glu Pro Glu Pro Glu Leu Glu Pro Glu Pro Asp 
            180                 185                 190         


Pro Glu Pro Glu Pro Asp Phe Glu Glu Arg Asp Glu Ser Glu Asp Ser 
        195                 200                 205             


<210>  3
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggcaacg cgcaggagcg gccgtcagag actatcgacc gcgagcggaa acgcctggtc       60

gagacgctgc aggcggactc gggactgctg ttggacgcgc tgctggcgcg gggcgtgctc      120

accgggccag agtacgaggc attggatgca ctgcctgatg ccgagcgcag ggtgcgccgc      180

ctactgctgc tggtgcaggg caagggcgag gccgcctgcc aggagctgct acgctgtgcc      240

cagcgtaccg cgggcgcgcc ggaccccgct tgggactggc agcacgtggg tccgggctac      300

cgggaccgca gctatgaccc tccatgccca ggccactgga cgccggaggc acccggctcg      360

gggaccacat gccccgggtt gcccagagct tcagaccctg acgaggccgg gggccctgag      420

ggctccgagg cggtgcaatc cggggacccg gaggagccag agccagagct ggaagctgag      480

gcctctaaag aggctgaacc ggagccggag ccagagccag agctggaacc cgaggctgaa      540

gcagaaccag agccggaact ggagccagaa ccggacccag agcccgagcc cgacttcgag      600

gaaagggacg agtccgaaga ttcctga                                          627


<210>  4
<211>  627
<212>  DNA
<213>  artificial

<220>
<223>  mutated ARC

<400>  4
atgggcaacg cgcaggagcg gccgtcagag actatcgacc gcgagcggag acgcctggtc       60

gagacgctgc aggcggactc gggactgctg ttggacgcgc tgctggcgcg gggcgtgctc      120

accgggccag agtacgaggc attggatgca ctgcctgatg ccgagcgcag ggtgcgccgc      180

ctactgctgc tggtgcaggg caggggcgag gccgcctgcc aggagctgct acgctgtgcc      240

cagcgtaccg cgggcgcgcc ggaccccgct tgggactggc agcacgtggg tccgggctac      300

cgggaccgca gctatgaccc tccatgccca ggccactgga cgccggaggc acccggctcg      360

gggaccacat gccccgggtt gcccagagct tcagaccctg acgaggccgg gggccctgag      420

ggctccgagg cggtgcaatc cgggaccccg gaggagccag agccagagct ggaagctgag      480

gcctctagag aggctgaacc ggagccggag ccagagccag agctggaacc cgaggctgaa      540

gcagaaccag agccggaact ggagccagaa ccggacccag agcccgagcc cgacttcgag      600

gaaagggacg agtccgaaga ttcctga                                          627


<210>  5
<211>  208
<212>  PRT
<213>  artificial

<220>
<223>  mutated ARC

<400>  5

Met Gly Asn Ala Gln Glu Arg Pro Ser Glu Thr Ile Asp Arg Glu Arg 
1               5                   10                  15      


Arg Arg Leu Val Glu Thr Leu Gln Ala Asp Ser Gly Leu Leu Leu Asp 
            20                  25                  30          


Ala Leu Leu Ala Arg Gly Val Leu Thr Gly Pro Glu Tyr Glu Ala Leu 
        35                  40                  45              


Asp Ala Leu Pro Asp Ala Glu Arg Arg Val Arg Arg Leu Leu Leu Leu 
    50                  55                  60                  


Val Gln Gly Arg Gly Glu Ala Ala Cys Gln Glu Leu Leu Arg Cys Ala 
65                  70                  75                  80  


Gln Arg Thr Ala Gly Ala Pro Asp Pro Ala Trp Asp Trp Gln His Val 
                85                  90                  95      


Gly Pro Gly Tyr Arg Asp Arg Ser Tyr Asp Pro Pro Cys Pro Gly His 
            100                 105                 110         


Trp Thr Pro Glu Ala Pro Gly Ser Gly Thr Thr Cys Pro Gly Leu Pro 
        115                 120                 125             


Arg Ala Ser Asp Pro Asp Glu Ala Gly Gly Pro Glu Gly Ser Glu Ala 
    130                 135                 140                 


Val Gln Ser Gly Thr Pro Glu Glu Pro Glu Pro Glu Leu Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Arg Glu Ala Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu 
                165                 170                 175     


Pro Glu Ala Glu Ala Glu Pro Glu Pro Glu Leu Glu Pro Glu Pro Asp 
            180                 185                 190         


Pro Glu Pro Glu Pro Asp Phe Glu Glu Arg Asp Glu Ser Glu Asp Ser 
        195                 200                 205             


<210>  6
<211>  627
<212>  DNA
<213>  artificial

<220>
<223>  mutated ARC

<400>  6
atgggcaacg cgcaggagcg gccgtcagag actatcgacc gcgagcggag acgcctggtc       60

gagacgctgc aggcggactc gggactgctg ttggacgcgc tgctggcgcg gggcgtgctc      120

accgggccag agtacgaggc attggatgca ctgcctgatg ccgagcgcag ggtgcgccgc      180

ctactgctgc tggtgcaggg caggggcgag gccgcctgcc aggagctgct acgctgtgcc      240

cagcgtaccg cgggcgcgcc ggaccccgct tgggactggc agcacgtggg tccgggctac      300

cgggaccgca gctatgaccc tccatgccca ggccactgga cgccggaggc acccggctcg      360

gggaccacat gccccgggtt gcccagagct tcagaccctg acgaggccgg gggccctgag      420

ggctccgagg cggtgcaatc cggggacccg gaggagccag agccagagct ggaagctgag      480

gcctctagag aggctgaacc ggagccggag ccagagccag agctggaacc cgaggctgaa      540

gcagaaccag agccggaact ggagccagaa ccggacccag agcccgagcc cgacttcgag      600

gaaagggacg agtccgaaga ttcctga                                          627


<210>  7
<211>  208
<212>  PRT
<213>  artificial

<220>
<223>  mutated ARC

<400>  7

Met Gly Asn Ala Gln Glu Arg Pro Ser Glu Thr Ile Asp Arg Glu Arg 
1               5                   10                  15      


Arg Arg Leu Val Glu Thr Leu Gln Ala Asp Ser Gly Leu Leu Leu Asp 
            20                  25                  30          


Ala Leu Leu Ala Arg Gly Val Leu Thr Gly Pro Glu Tyr Glu Ala Leu 
        35                  40                  45              


Asp Ala Leu Pro Asp Ala Glu Arg Arg Val Arg Arg Leu Leu Leu Leu 
    50                  55                  60                  


Val Gln Gly Arg Gly Glu Ala Ala Cys Gln Glu Leu Leu Arg Cys Ala 
65                  70                  75                  80  


Gln Arg Thr Ala Gly Ala Pro Asp Pro Ala Trp Asp Trp Gln His Val 
                85                  90                  95      


Gly Pro Gly Tyr Arg Asp Arg Ser Tyr Asp Pro Pro Cys Pro Gly His 
            100                 105                 110         


Trp Thr Pro Glu Ala Pro Gly Ser Gly Thr Thr Cys Pro Gly Leu Pro 
        115                 120                 125             


Arg Ala Ser Asp Pro Asp Glu Ala Gly Gly Pro Glu Gly Ser Glu Ala 
    130                 135                 140                 


Val Gln Ser Gly Asp Pro Glu Glu Pro Glu Pro Glu Leu Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Arg Glu Ala Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu 
                165                 170                 175     


Pro Glu Ala Glu Ala Glu Pro Glu Pro Glu Leu Glu Pro Glu Pro Asp 
            180                 185                 190         


Pro Glu Pro Glu Pro Asp Phe Glu Glu Arg Asp Glu Ser Glu Asp Ser 
        195                 200                 205             


<210>  8
<211>  984
<212>  DNA
<213>  artificial

<220>
<223>  expression construct for ARC

<400>  8
atctcgatcc cgcgaaatta atacgactca ctatagggag accacaacgg tttccctcta       60

gataattttg tttaacttta agaaggagat atacatatgc ggggttctca tcatcatcat      120

catcatggta tggctagcat gactggtgga cagcaaatgg gtcgggatct gtacgacgat      180

gacgataagg atcgatgggg atccaagctt ggctacggcc gcaagaaacg ccgccagcgc      240

cgccgcggtg gatccaccat ggccatgtcc ggctatccat atgacgtccc agactatgct      300

ggctccatgg ccggtaccat gggcaacgcg caggagcggc cgtcagagac tatcgaccgc      360

gagcggaaac gcctggtcga gacgctgcag gcggactcgg gactgctgtt ggacgcgctg      420

ctggcgcggg gcgtgctcac cgggccagag tacgaggcat tggatgcact gcctgatgcc      480

gagcgcaggg tgcgccgcct actgctgctg gtgcagggca agggcgaggc cgcctgccag      540

gagctgctac gctgtgccca gcgtaccgcg ggcgcgccgg accccgcttg ggactggcag      600

cacgtgggtc cgggctaccg ggaccgcagc tatgaccctc catgcccagg ccactggacg      660

ccggaggcac ccggctcggg gaccacatgc cccgggttgc ccagagcttc agaccctgac      720

gaggccgggg gccctgaggg ctccgaggcg gtgcaatccg ggaccccgga ggagccagag      780

ccagagctgg aagctgaggc ctctaaagag gctgaaccgg agccggagcc agagccagag      840

ctggaacccg aggctgaagc agaaccagag ccggaactgg agccagaacc ggacccagag      900

cccgagcccg acttcgagga aagggacgag tccgaagatt cctgaggtac cggtctcgag      960

gtgcatgcgg tgaattcgaa gctt                                             984


<210>  9
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ala Met Ser Gly Tyr Pro Tyr Asp Val 
    50                  55                  60                  


Pro Asp Tyr Ala Gly Ser Met Ala Gly Thr Met Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Arg Pro Ser Glu Thr Ile Asp Arg Glu Arg Lys Arg Leu Val Glu Thr 
                85                  90                  95      


Leu Gln Ala Asp Ser Gly Leu Leu Leu Asp Ala Leu Leu Ala Arg Gly 
            100                 105                 110         


Val Leu Thr Gly Pro Glu Tyr Glu Ala Leu Asp Ala Leu Pro Asp Ala 
        115                 120                 125             


Glu Arg Arg Val Arg Arg Leu Leu Leu Leu Val Gln Gly Lys Gly Glu 
    130                 135                 140                 


Ala Ala Cys Gln Glu Leu Leu Arg Cys Ala Gln Arg Thr Ala Gly Ala 
145                 150                 155                 160 


Pro Asp Pro Ala Trp Asp Trp Gln His Val Gly Pro Gly Tyr Arg Asp 
                165                 170                 175     


Arg Ser Tyr Asp Pro Pro Cys Pro Gly His Trp Thr Pro Glu Ala Pro 
            180                 185                 190         


Gly Ser Gly Thr Thr Cys Pro Gly Leu Pro Arg Ala Ser Asp Pro Asp 
        195                 200                 205             


Glu Ala Gly Gly Pro Glu Gly Ser Glu Ala Val Gln Ser Gly Thr Pro 
    210                 215                 220                 


Glu Glu Pro Glu Pro Glu Leu Glu Ala Glu Ala Ser Lys Glu Ala Glu 
225                 230                 235                 240 


Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu Pro Glu Ala Glu Ala Glu 
                245                 250                 255     


Pro Glu Pro Glu Leu Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Asp 
            260                 265                 270         


Phe Glu Glu Arg Asp Glu Ser Glu Asp Ser 
        275                 280         


<210>  10
<211>  177
<212>  DNA
<213>  human immunodificiency virus

<400>  10
atgcggggtt ctggtatggc tagcatgact ggtggacagc aaatgggtcg ggatctgtac       60

gacgatgacg ataaggatcg atggggatcc aagcttggct acggccgcaa gaaacgccgc      120

cagcgccgcc gcggtggatc caccatggcc atgtccggcg gctccatggc cggtacc         177


<210>  11
<211>  59
<212>  PRT
<213>  human immunodeficiency virus

<400>  11

Met Arg Gly Ser Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10                  15      


Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg Trp Gly Ser Lys Leu 
            20                  25                  30          


Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Ser Thr 
        35                  40                  45              


Met Ala Met Ser Gly Gly Ser Met Ala Gly Thr 
    50                  55                  


<210>  12
<211>  804
<212>  DNA
<213>  artificial

<220>
<223>  fusion construct

<400>  12
atgcggggtt ctggtatggc tagcatgact ggtggacagc aaatgggtcg ggatctgtac       60

gacgatgacg ataaggatcg atggggatcc aagcttggct acggccgcaa gaaacgccgc      120

cagcgccgcc gcggtggatc caccatggcc atgtccggcg gctccatggc cggtaccatg      180

ggcaacgcgc aggagcggcc gtcagagact atcgaccgcg agcggaaacg cctggtcgag      240

acgctgcagg cggactcggg actgctgttg gacgcgctgc tggcgcgggg cgtgctcacc      300

gggccagagt acgaggcatt ggatgcactg cctgatgccg agcgcagggt gcgccgccta      360

ctgctgctgg tgcagggcaa gggcgaggcc gcctgccagg agctgctacg ctgtgcccag      420

cgtaccgcgg gcgcgccgga ccccgcttgg gactggcagc acgtgggtcc gggctaccgg      480

gaccgcagct atgaccctcc atgcccaggc cactggacgc cggaggcacc cggctcgggg      540

accacatgcc ccgggttgcc cagagcttca gaccctgacg aggccggggg ccctgagggc      600

tccgaggcgg tgcaatccgg gaccccggag gagccagagc cagagctgga agctgaggcc      660

tctaaagagg ctgaaccgga gccggagcca gagccagagc tggaacccga ggctgaagca      720

gaaccagagc cggaactgga gccagaaccg gacccagagc ccgagcccga cttcgaggaa      780

agggacgagt ccgaagattc ctga                                             804


<210>  13
<211>  267
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  13

Met Arg Gly Ser Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10                  15      


Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg Trp Gly Ser Lys Leu 
            20                  25                  30          


Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Ser Thr 
        35                  40                  45              


Met Ala Met Ser Gly Gly Ser Met Ala Gly Thr Met Gly Asn Ala Gln 
    50                  55                  60                  


Glu Arg Pro Ser Glu Thr Ile Asp Arg Glu Arg Lys Arg Leu Val Glu 
65                  70                  75                  80  


Thr Leu Gln Ala Asp Ser Gly Leu Leu Leu Asp Ala Leu Leu Ala Arg 
                85                  90                  95      


Gly Val Leu Thr Gly Pro Glu Tyr Glu Ala Leu Asp Ala Leu Pro Asp 
            100                 105                 110         


Ala Glu Arg Arg Val Arg Arg Leu Leu Leu Leu Val Gln Gly Lys Gly 
        115                 120                 125             


Glu Ala Ala Cys Gln Glu Leu Leu Arg Cys Ala Gln Arg Thr Ala Gly 
    130                 135                 140                 


Ala Pro Asp Pro Ala Trp Asp Trp Gln His Val Gly Pro Gly Tyr Arg 
145                 150                 155                 160 


Asp Arg Ser Tyr Asp Pro Pro Cys Pro Gly His Trp Thr Pro Glu Ala 
                165                 170                 175     


Pro Gly Ser Gly Thr Thr Cys Pro Gly Leu Pro Arg Ala Ser Asp Pro 
            180                 185                 190         


Asp Glu Ala Gly Gly Pro Glu Gly Ser Glu Ala Val Gln Ser Gly Thr 
        195                 200                 205             


Pro Glu Glu Pro Glu Pro Glu Leu Glu Ala Glu Ala Ser Lys Glu Ala 
    210                 215                 220                 


Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu Pro Glu Ala Glu Ala 
225                 230                 235                 240 


Glu Pro Glu Pro Glu Leu Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro 
                245                 250                 255     


Asp Phe Glu Glu Arg Asp Glu Ser Glu Asp Ser 
            260                 265         


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  15
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  15
tacggccgca agaaacgccg ccagcgccgc cgc                                    33


<210>  16
<211>  19
<212>  PRT
<213>  Drosophila

<400>  16

Ser Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Cys 
            


<210>  17
<211>  12
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  17

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  18

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  19
<211>  11
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  19

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  20
<211>  8
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  20

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  21

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  22
<211>  9
<212>  PRT
<213>  unknown

<220>
<223>  PTD

<400>  22

Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   


