
                                SEQUENCE LISTING


<110> Calmune Corporation
      Williamson, Robert Anthony
      Wadia, Jehangir
      Wagner, Michelle

<120> ANTIBODIES AGAINST CANDIDA, COLLECTIONS
  THEREOF AND METHODS OF USE
  

<130> 3800013.00029/1157PC

<150> 61/277,091          
<151> 2009-09-18  

<150> 61/341,175          
<151> 2010-03-25  

<160> 713

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL IT*

<400> 1
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL3

<400> 2
Gln His Tyr Ala Gly Tyr Ser Ala Thr
 1               5                  


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala CDRL3

<400> 3
Gln His Ala Ala Gly Ala Ala Ala Thr
 1               5                  


<210> 4
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3-ALA pCAL IT* (contains 3Ala CDRH3)

<400> 4
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tgcggcggac gcggacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 5
<211> 3513
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL G13

<400> 5
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gcctaactct ggctggtttc gctaccgtaa ccggtttaat taataaggag gatataatta 2280
tgaaaaagac agctatcgcg attgcagtgg cactggctgg tttcgctacc gtagcccagg 2340
cggccgcacg cgtctggttg aatctggtgg ggtctggaat tctgcgatcg cggccaggcc 2400
ggccgcacca tcaccatcac catggcgcat acccgtacga cgttccggac tacgcttcta 2460
ctagttagga gggtggtggc tctgagggtg gcggttctga gggtggcggc tctgagggag 2520
gcggttccgg tggtggctct ggttccggtg attttgatta tgaaaagatg gcaaacgcta 2580
ataagggggc tatgaccgaa aatgccgatg aaaacgcgct acagtctgac gctaaaggca 2640
aacttgattc tgtcgctact gattacggtg ctgctatcga tggtttcatt ggtgacgttt 2700
ccggccttgc taatggtaat ggtgctactg gtgattttgc tggctctaat tcccaaatgg 2760
ctcaagtcgg tgacggtgat aattcacctt taatgaataa tttccgtcaa tatttacctt 2820
ccctccctca atcggttgaa tgtcgccctt ttgtctttgg cgctggtaaa ccatatgaat 2880
tttctattga ttgtgacaaa ataaacttat tccgtggtgt ctttgcgttt cttttatatg 2940
ttgccacctt tatgtatgta ttttctacgt ttgctaacat actgcgtaat aaggagtctt 3000
aagctagcta acgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg 3060
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca 3120
cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc 3180
gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct 3240
ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg 3300
ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc 3360
ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg 3420
attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg 3480
aattttaaca aaatattaac gcttacaatt tag                              3513

<210> 6
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL G13 vector

<400> 6
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 7
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab light chain

<400> 7
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcagaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 8
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab heavy chain

<400> 8
gaagttcagc tggttgaatc tggtggtggt ctggttaaag ctggtggttc tctgatcctg 60
tcttgcggtg tttctaactt ccgtatctct gctcacacca tgaactgggt tcgtcgtgtt 120
ccgggtggtg gtctggaatg ggttgcttct atctctacct cttctaccta ccgtgactac 180
gctgacgctg ttaaaggtcg tttcaccgtt tctcgtgacg acctggaaga cttcgtttac 240
ctgcagatgc ataaaatgcg tgttgaagac accgctatct actactgcgc tcgtaaaggt 300
tctgaccgtc tgtctgacaa cgacccgttc gacgcttggg gtccgggtac cgttgttacc 360
gtttctccgg cgtcgaccaa aggtccgtct gttttcccgc tggctccgtc ttctaaatct 420
acctctggtg gtaccgctgc tctgggttgc ctggttaaag actacttccc ggaaccggtt 480
accgtttctt ggaactctgg tgctctgacc tctggtgttc acaccttccc ggctgttctg 540
cagtcttctg gtctgtactc tctgtcttct gttgttaccg ttccgtcttc ttctctgggt 600
acccagacct acatctgcaa cgttaaccac aaaccgtcta acaccaaagt tgacaagaaa 660
gttgaaccga aatcttgcct gcga                                        684

<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HA tag

<400> 9
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 10
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Fab Heavy Chain

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Leu Arg
225             


<210> 11
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Fab Light Chain

<400> 11
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 12
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL ITPO

<400> 12
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcccagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc caggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 13
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF primer

<400> 13
gccgctgtgc catcgctcag taacaattga attaaggagg a                     41

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3R primer

<400> 14
atagtgctgg cagtggtagg                                             20

<210> 15
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 reference sequence

<400> 15
ctacctacca ctgccagcac tacgctggtt actctgctac cttcggtcag ggtac      55

<210> 16
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34
<223> n = a, g, c or t

<220> 
<221> variation      
<222> 26, 29, 32, 35
<223> k = g or t

<400> 16
ctacctacca ctgccagcac tatnnknnkn nknnkgctac cttcggtcag ggtac      55

<210> 17
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS+1 primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34, 36-37
<223> n = a, c, g or t

<220> 
<221> variation      
<222> 26, 29, 32, 35, 38
<223> k = g or t

<400> 17
ctacctacca ctgccagcac tatnnknnkn nknnknnkgc taccttcggt cagggtac   58

<210> 18
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS+2 primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34, 36-37, 39-40
<223> n = a, c, t, or g

<220> 
<221> variation      
<222> 26, 29, 32, 35, 38, 41
<223> k = g or t

<400> 18
ctacctacca ctgccagcac tatnnknnkn nknnknnknn kgctaccttc ggtcagggta 60
c                                                                 61

<210> 19
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR primer

<400> 19
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 20
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> MfeI restriction site

<400> 20
caattg                                                            6

<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24 primer

<400> 21
gccgctgtgc catcgctcag taac                                        24

<210> 22
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> PacI restriction site

<400> 22
ttaattaa                                                          8

<210> 23
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA LC pCAL IT* (contains 3-Ala CDRL3)

<400> 23
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcacgccgcg ggtgcggccg cgaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 24
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> L1R primer

<400> 24
gggcggcgct cttcgtagcg aagtcgtcga actg                             34

<210> 25
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35
<223> n = a, c, g or t

<220> 
<221> variation      
<222> 24, 27, 30, 33
<223> m = a or c

<400> 25
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnatagt gctggcagtg gtagg      55

<210> 26
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA+1 primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35, 37-38
<223> n = a, c, t, or g

<220> 
<221> variation      
<222> 24, 27, 30, 33, 36
<223> m = a or c

<400> 26
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnmnnat agtgctggca gtggtagg   58

<210> 27
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA+2 primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35, 37-38, 40-41
<223> n = a, c, t or g

<220> 
<221> variation      
<222> 24, 27, 30, 33, 36, 39
<223> m = a or c

<400> 27
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnmnnmn natagtgctg gcagtggtag 60
g                                                                 61

<210> 28
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> L2F primer

<400> 28
gggcggcgct cttccccgtg ttgaaatcaa acgt                             34

<210> 29
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> SapI restriction site

<220> 
<221> variation      
<222> 10
<223> n = a or c or g or t

<400> 29
gctcttcn                                                          8

<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 30
Gln His Tyr Lys Glu Trp Arg Ala Thr
 1               5                  


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 31
Gln His Tyr Lys Glu Trp Ser Ala Thr
 1               5                  


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 32
Gln His Tyr Arg Glu Trp Ser Ala Thr
 1               5                  


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 33
Gln His Tyr Leu Ala Trp Ser Ala Thr
 1               5                  


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 34
Gln His Tyr Lys Glu Trp Trp Ala Thr
 1               5                  


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 35
Gln His Tyr Arg Glu Trp Trp Ala Thr
 1               5                  


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 36
Gln His Tyr Leu Ser Trp Ser Ala Thr
 1               5                  


<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 37
Gln His Tyr Lys Pro Phe Asn Ala Thr
 1               5                  


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 38
Gln His Tyr Arg Pro Phe Asn Ala Thr
 1               5                  


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 39
Gln His Tyr Met Pro Phe Asn Ala Thr
 1               5                  


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 40
Gln His Tyr Gln Pro Phe Asn Ala Thr
 1               5                  


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 41
Gln His Tyr Leu Pro Phe Asn Ala Thr
 1               5                  


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 42
Gln His Tyr Glu Pro Phe Asn Ala Thr
 1               5                  


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 43
Gln His Tyr Lys Pro Phe Glu Ala Thr
 1               5                  


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 44
Gln His Tyr Arg Pro Phe Glu Ala Thr
 1               5                  


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 45
Gln His Tyr Lys Pro Phe Gln Ala Thr
 1               5                  


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 46
Gln His Tyr Arg Pro Phe Gln Ala Thr
 1               5                  


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 47
Gln His Tyr Gln Pro Phe Gln Ala Thr
 1               5                  


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 48
Gln His Tyr Ile Pro Phe Gln Ala Thr
 1               5                  


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 49
Gln His Tyr Lys Pro Phe Ser Ala Ser
 1               5                  


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 50
Gln His Tyr Arg Pro Phe Ser Ala Thr
 1               5                  


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 51
Gln His Tyr Gln Pro Phe Ser Ala Thr
 1               5                  


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 52
Gln His Tyr Val Pro Phe Ser Ala Thr
 1               5                  


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 53
Gln His Tyr His Pro Phe Ser Ala Thr
 1               5                  


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 54
Gln His Tyr Lys Pro Phe His Ala Thr
 1               5                  


<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 55
Gln His Tyr Arg Pro Phe His Ala Thr
 1               5                  


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 56
Gln His Tyr Met Pro Phe His Ala Thr
 1               5                  


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 57
Gln His Tyr Glu Pro Phe His Ala Thr
 1               5                  


<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 58
Gln His Tyr Lys Pro Phe Arg Ala Thr
 1               5                  


<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 59
Gln His Tyr Val Pro Phe Arg Ala Thr
 1               5                  


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 60
Gln His Tyr Glu Pro Phe Arg Ala Thr
 1               5                  


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 61
Gln His Tyr Lys Pro Phe Ala Ala Thr
 1               5                  


<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 62
Gln His Tyr Val Pro Phe Ala Ala Thr
 1               5                  


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 63
Gln His Tyr Ile Pro Phe Ala Ala Thr
 1               5                  


<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 64
Gln His Tyr Lys Pro Phe Asp Ala Thr
 1               5                  


<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 65
Gln His Tyr Met Pro Phe Asp Ala Thr
 1               5                  


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 66
Gln His Tyr Met Pro Phe Lys Ala Thr
 1               5                  


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 67
Gln His Tyr Met Pro Phe Thr Ala Thr
 1               5                  


<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 68
Gln His Tyr Met Pro Phe Pro Ala Thr
 1               5                  


<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 69
Gln His Tyr Gln Pro Phe Trp Ala Thr
 1               5                  


<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 70
Gln His Tyr Ser Pro Phe Trp Ala Thr
 1               5                  


<210> 71
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 71
Gln His Tyr Met Pro Tyr Arg Ala Ser
 1               5                  


<210> 72
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 72
Gln His Tyr Lys Pro Tyr Arg Ala Thr
 1               5                  


<210> 73
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 73
Gln His Tyr Met Pro Tyr Arg Ala Thr
 1               5                  


<210> 74
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 74
Gln His Tyr Gln Pro Tyr Arg Ala Thr
 1               5                  


<210> 75
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 75
Gln His Tyr Leu Pro Tyr Arg Ala Thr
 1               5                  


<210> 76
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 76
Gln His Tyr Glu Pro Tyr Arg Ala Thr
 1               5                  


<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 77
Gln His Tyr Lys Pro Tyr Asp Ala Thr
 1               5                  


<210> 78
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 78
Gln His Tyr Lys Pro Tyr Ser Ala Thr
 1               5                  


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 79
Gln His Tyr Gln Pro Tyr Val Ala Thr
 1               5                  


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 80
Gln His Tyr Glu Pro Tyr Lys Ala Thr
 1               5                  


<210> 81
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 81
Gln His Tyr Leu Pro Tyr Gln Ala Ser
 1               5                  


<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 82
Gln His Tyr Arg Pro His Thr Gly Ala Thr
 1               5                  10  


<210> 83
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 83
Gln His Tyr Thr Ala His Asp Gly Ala Thr
 1               5                  10  


<210> 84
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 84
Gln His Tyr Thr Ala His Arg Gly Ala Thr
 1               5                  10  


<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 85
Gln His Tyr Arg Ala His Thr Gly Ala Thr
 1               5                  10  


<210> 86
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 86
Gln His Tyr Thr Ala His Thr Gly Ala Thr
 1               5                  10  


<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 87
Gln His Tyr Thr Asp His His Gly Ala Thr
 1               5                  10  


<210> 88
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 88
Gln His Tyr Thr Asp His Lys Gly Ala Thr
 1               5                  10  


<210> 89
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 89
Gln His Tyr Thr Asp His Arg Gly Ala Thr
 1               5                  10  


<210> 90
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 90
Gln His Tyr Thr Asp His Tyr Gly Ala Thr
 1               5                  10  


<210> 91
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 91
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 92
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 92
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 93
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 93
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 94
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 94
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ala Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 95
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 95
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 96
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 96
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 97
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 97
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ser Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 98
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 98
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 99
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 99
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 100
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 100
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 101
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 101
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 102
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 102
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 103
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 103
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 104
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 104
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 105
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 105
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 106
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 106
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 107
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 107
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 108
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 108
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 109
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 109
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 110
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 110
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ser
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 111
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 111
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 112
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 112
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 113
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 113
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 114
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 114
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr His Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 115
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 115
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 116
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 116
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 117
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 117
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 118
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 118
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 119
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 119
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 120
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 120
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 121
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 121
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 122
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 122
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 123
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 123
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 124
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 124
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 125
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 125
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 126
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 126
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 127
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 127
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 128
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 128
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Thr
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 129
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 129
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Pro
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 130
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 130
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 131
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 131
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Pro Phe Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 132
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 132
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 133
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 133
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 134
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 134
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 135
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 135
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 136
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12  light chain variant

<400> 136
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 137
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 137
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 138
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 138
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 139
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 139
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 140
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 140
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Val
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 141
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 141
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 142
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 142
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Gln
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 143
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 143
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 144
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 144
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Asp
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 145
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 145
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Arg
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 146
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 146
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Ala His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 147
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 147
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 148
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 148
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His His
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 149
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 149
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Lys
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 150
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 150
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Arg
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 151
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 151
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Tyr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 152
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH3

<400> 152
Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
 1               5                  10                  


<210> 153
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRH3

<400> 153
Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
 1               5                  10                  


<210> 154
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 VH domain

<400> 154
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro
        115                 120             


<210> 155
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 VL domain

<400> 155
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105         


<210> 156
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRH3 VH domain

<400> 156
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro
        115                 120             


<210> 157
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 VL domain

<400> 157
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105             


<210> 158
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRH3 Fab Heavy Chain

<400> 158
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Leu Arg
225             


<210> 159
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 Fab Light Chain

<400> 159
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 160
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 IgG Heavy Chain

<400> 160
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 161
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Fab Heavy Chain

<400> 161
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys
225     


<210> 162
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Light Chain

<400> 162
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 163
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH1

<400> 163
Ala His Thr Met Asn
 1               5  


<210> 164
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH2

<400> 164
Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 165
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL1

<400> 165
Arg Ala Ser Gln Ser Ile Glu Thr Trp Leu Ala
 1               5                  10      


<210> 166
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL2

<400> 166
Lys Ala Ser Thr Leu Lys Thr
 1               5          


<210> 167
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant V5L, H230S

<400> 167
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Ser Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 168
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D1 V5L (H230 deletion)

<400> 168
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 169
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D2 V5L (T229-H230 deletion)

<400> 169
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 170
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D3 V5L (K228-H230 deletion)

<400> 170
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 171
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D4 V5L (D227-H230 deletion)

<400> 171
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 172
<211> 447
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D6 V5L (D227-C232 deletion)

<400> 172
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445         


<210> 173
<211> 447
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D6GG V5L (D227-C232 deletion)

<400> 173
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Gly Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445         


<210> 174
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D2 (T229-H230 deletion)

<400> 174
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 175
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Calmune 2G12 VH domain

<400> 175
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro
        115                 120             


<210> 176
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Calmune 2G12 VL domain

<400> 176
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105             


<210> 177
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 VL domain

<400> 177
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105         


<210> 178
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 Fab Light Chain

<400> 178
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 179
<211> 6840
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab hinge in petDuet

<400> 179
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
agctgcgata aaacccatac ctgcccgccg tgcccgcacc atcaccatca ccatggcgca 1740
tacccgtacg acgttccgga ctacgcttct tagctcgagt ctggtaaaga aaccgctgct 1800
gcgaaatttg aacgccagca catggactcg tctactagcg cagcttaatt aacctaggct 1860
gctgccaccg ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg 1920
ggttttttgc tgaaaggagg aactatatcc ggattggcga atgggacgcg ccctgtagcg 1980
gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 2040
ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 2100
cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 2160
tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 2220
cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 2280
ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 2340
tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 2400
aaatattaac gtttacaatt tctggcggca cgatggcatg agattatcaa aaaggatctt 2460
cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta 2520
aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct 2580
atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg 2640
cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga 2700
tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt 2760
atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt 2820
taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt 2880
tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat 2940
gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc 3000
cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc 3060
cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat 3120
gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag 3180
aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt 3240
accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc 3300
ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa 3360
gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatcatgatt 3420
gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa 3480
ataaacaaat aggtcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 3540
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 3600
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 3660
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt 3720
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 3780
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 3840
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 3900
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 3960
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 4020
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 4080
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 4140
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 4200
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 4260
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 4320
gtgagcgagg aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt 4380
atttcacacc gcatatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa 4440
gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc 4500
aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc 4560
tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc 4620
gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg 4680
ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc ttctgataaa 4740
gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg tgtaaggggg 4800
atttctgttc atgggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt 4860
tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg 4920
gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga 4980
tgtaggtgtt ccacagggta gccagcagca tcctgcgatg cagatccgga acataatggt 5040
gcagggcgct gacttccgcg tttccagact ttacgaaaca cggaaaccga agaccattca 5100
tgttgttgct caggtcgcag acgttttgca gcagcagtcg cttcacgttc gctcgcgtat 5160
cggtgattca ttctgctaac cagtaaggca accccgccag cctagccggg tcctcaacga 5220
caggagcacg atcatgctag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa 5280
ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat 5340
tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg 5400
aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt 5460
tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca 5520
gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg 5580
gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac 5640
caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg 5700
caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac 5760
cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga 5820
gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta 5880
acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt 5940
cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg 6000
ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt 6060
taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt 6120
cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag 6180
atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc 6240
caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca 6300
gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt 6360
tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg 6420
ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac 6480
cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac 6540
tcctgcatta ggaagcagcc cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg 6600
aatggtgcat gcaaggagat ggcgcccaac agtcccccgg ccacggggcc tgccaccata 6660
cccacgccga aacaagcgct catgagcccg aagtggcgag cccgatcttc cccatcggtg 6720
atgtcggcga tataggcgcc agcaaccgca cctgtggcgc cggtgatgcc ggccacgatg 6780
cgtccggcgt agaggatcga gatcgatctc gatcccgcga aattaatacg actcactata 6840




<210> 180
<211> 6121
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 domain exchanged scFv

<400> 180
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgggc 5880
caggccggcc agcaccatca ccatcaccat ggcgcatacc cgtacgacgt tccggactac 5940
gcttcttagg cggccgcact cgagcaccac caccaccacc actgagatcc ggctgctaac 6000
aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc 6060
cttggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga 6120
t                                                                 6121


<210> 181
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 1

<400> 181
ggtggttcgt ctggatcttc ctcctctggt ggcggtggct cgggcggtgg tggc       54

<210> 182
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 2

<400> 182
ggaggatccg gcagcagcag cagcggcggc ggcggcggga gctccggcgg cgga       54

<210> 183
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> L216

<400> 183
ggaggatccg gcagcagcag cagcggcggc gggagctccg gcggcgga              48

<210> 184
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> L217

<400> 184
ggaggatccg gcagcagcag cagcggcggc ggcgggagct ccggcggcgg a          51

<210> 185
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> L219

<400> 185
ggaggatcca gcggcagcag cagcagcggc ggcggcggcg ggagctccgg cggcgga    57

<210> 186
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> L220

<400> 186
ggaggatcca gcggcggcag cagcagcagc ggcggcggcg gcgggagctc cggcggcgga 60


<210> 187
<211> 87
<212> DNA
<213> Artificial Sequence

<220> 
<223> BamHISacI linker / BamHISacI(+)

<400> 187
gatccggtgg cggcagcgaa ggtggtggca gcgaaggtgg cggtagcgaa ggtggcggca 60
gcgaaggcgg cggtagcggt gggagct                                     87

<210> 188
<211> 6916
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 domain exchanged scFv tandem

<400> 188
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggga 5880
ggatccggca gcagcagcag cggcggcggc ggcgggagct ccggcggcgg agaagttcag 5940
ctggttgaat ctggtggtgg tctggttaaa gctggtggtt ctctgatcct gtcttgcggt 6000
gtttctaact tccgtatctc tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt 6060
ggtctggaat gggttgcttc tatctctacc tcttctacct accgtgacta cgctgacgct 6120
gttaaaggtc gtttcaccgt ttctcgtgac gacctggaag acttcgttta cctgcagatg 6180
cacaaaatgc gtgttgaaga caccgctatc tactactgcg ctcgtaaagg ttctgaccgt 6240
ctgtctgaca acgacccgtt cgacgcttgg ggtccgggta ccgttgttac cgtttctccg 6300
ggtggttcgt ctggatcttc ctcctctggt ggcggtggct cgggcggtgg tggcgttgtt 6360
atgacccagt ctccgtctac cctgtctgct tctgttggtg acaccatcac catcacctgc 6420
cgtgcttctc agtctatcga aacctggctg gcttggtacc agcagaaacc gggtaaagct 6480
ccgaaactgc tgatctacaa ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct 6540
ggttctggtt ctggtaccga gttcaccctg accatctctg gtctgcagtt cgacgacttc 6600
gctacctacc actgccagca ctacgctggt tactctgcta ccttcggtca gggtacccgt 6660
gttgaaatca aaggccaggc cggccagcac catcaccatc accatggcgc atacccgtac 6720
gacgttccgg actacgcttc ttaggcggcc gcactcgagc accaccacca ccaccactga 6780
gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 6840
taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 6900
ggaactatat ccggat                                                 6916


<210> 189
<211> 6166
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 domain exchanged scFv hinge(E)

<400> 189
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggaa 5880
ccgaaaagct gcgataaaac ccatacctgc ccgccgtgcc cgggccaggc cggccagcac 5940
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc ttaggcggcc 6000
gcactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa 6060
gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa 6120
cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggat                6166


<210> 190
<211> 6163
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 domain exchanged scFv hinge
      deltaE

<400> 190
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgccg 5880
aaaagctgcg ataaaaccca tacctgcccg ccgtgcccgg gccaggccgg ccagcaccat 5940
caccatcacc atggcgcata cccgtacgac gttccggact acgcttctta ggcggccgca 6000
ctcgagcacc accaccacca ccactgagat ccggctgcta acaaagcccg aaaggaagct 6060
gagttggctg ctgccaccgc tgagcaataa ctagcataac cccttggggc ctctaaacgg 6120
gtcttgaggg gttttttgct gaaaggagga actatatccg gat                   6163


<210> 191
<211> 6819
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 Fab Cys19 construct

<400> 191
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgtgcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
tcttgcggca gcagccacca tcaccatcac catggcgcat acccgtacga cgttccggac 1740
tacgcttctt agctcgagtc tggtaaagaa accgctgctg cgaaatttga acgccagcac 1800
atggactcgt ctactagcgc agcttaatta acctaggctg ctgccaccgc tgagcaataa 1860
ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga 1920
actatatccg gattggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 1980
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 2040
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 2100
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 2160
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 2220
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 2280
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 2340
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt 2400
ctggcggcac gatggcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta 2460
aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca 2520
atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc 2580
ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc 2640
tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc 2700
agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat 2760
taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt 2820
tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc 2880
cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag 2940
ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt 3000
tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac 3060
tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg 3120
cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat 3180
tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc 3240
gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc 3300
tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa 3360
atgttgaata ctcatactct tcctttttca atcatgattg aagcatttat cagggttatt 3420
gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggtcatgacc 3480
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 3540
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 3600
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 3660
actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 3720
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 3780
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 3840
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 3900
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 3960
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 4020
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 4080
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 4140
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 4200
tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat 4260
accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag 4320
cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatatggt 4380
gcactctcag tacaatctgc tctgatgccg catagttaag ccagtataca ctccgctatc 4440
gctacgtgac tgggtcatgg ctgcgccccg acacccgcca acacccgctg acgcgccctg 4500
acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg 4560
catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg aggcagctgc ggtaaagctc 4620
atcagcgtgg tcgtgaagcg attcacagat gtctgcctgt tcatccgcgt ccagctcgtt 4680
gagtttctcc agaagcgtta atgtctggct tctgataaag cgggccatgt taagggcggt 4740
tttttcctgt ttggtcactg atgcctccgt gtaaggggga tttctgttca tgggggtaat 4800
gataccgatg aaacgagaga ggatgctcac gatacgggtt actgatgatg aacatgcccg 4860
gttactggaa cgttgtgagg gtaaacaact ggcggtatgg atgcggcggg accagagaaa 4920
aatcactcag ggtcaatgcc agcgcttcgt taatacagat gtaggtgttc cacagggtag 4980
ccagcagcat cctgcgatgc agatccggaa cataatggtg cagggcgctg acttccgcgt 5040
ttccagactt tacgaaacac ggaaaccgaa gaccattcat gttgttgctc aggtcgcaga 5100
cgttttgcag cagcagtcgc ttcacgttcg ctcgcgtatc ggtgattcat tctgctaacc 5160
agtaaggcaa ccccgccagc ctagccgggt cctcaacgac aggagcacga tcatgctagt 5220
catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg 5280
agatcccggt gcctaatgag tgagctaact tacattaatt gcgttgcgct cactgcccgc 5340
tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag 5400
aggcggtttg cgtattgggc gccagggtgg tttttctttt caccagtgag acgggcaaca 5460
gctgattgcc cttcaccgcc tggccctgag agagttgcag caagcggtcc acgctggttt 5520
gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg cgggatataa catgagctgt 5580
cttcggtatc gtcgtatccc actaccgaga tgtccgcacc aacgcgcagc ccggactcgg 5640
taatggcgcg cattgcgccc agcgccatct gatcgttggc aaccagcatc gcagtgggaa 5700
cgatgccctc attcagcatt tgcatggttt gttgaaaacc ggacatggca ctccagtcgc 5760
cttcccgttc cgctatcggc tgaatttgat tgcgagtgag atatttatgc cagccagcca 5820
gacgcagacg cgccgagaca gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac 5880
ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc ttcatgggag aaaataatac 5940
tgttgatggg tgtctggtca gagacatcaa gaaataacgc cggaacatta gtgcaggcag 6000
cttccacagc aatggcatcc tggtcatcca gcggatagtt aatgatcagc ccactgacgc 6060
gttgcgcgag aagattgtgc accgccgctt tacaggcttc gacgccgctt cgttctacca 6120
tcgacaccac cacgctggca cccagttgat cggcgcgaga tttaatcgcc gcgacaattt 6180
gcgacggcgc gtgcagggcc agactggagg tggcaacgcc aatcagcaac gactgtttgc 6240
ccgccagttg ttgtgccacg cggttgggaa tgtaattcag ctccgccatc gccgcttcca 6300
ctttttcccg cgttttcgca gaaacgtggc tggcctggtt caccacgcgg gaaacggtct 6360
gataagagac accggcatac tctgcgacat cgtataacgt tactggtttc acattcacca 6420
ccctgaattg actctcttcc gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt 6480
cgatggtgtc cgggatctcg acgctctccc ttatgcgact cctgcattag gaagcagccc 6540
agtagtaggt tgaggccgtt gagcaccgcc gccgcaagga atggtgcatg caaggagatg 6600
gcgcccaaca gtcccccggc cacggggcct gccaccatac ccacgccgaa acaagcgctc 6660
atgagcccga agtggcgagc ccgatcttcc ccatcggtga tgtcggcgat ataggcgcca 6720
gcaaccgcac ctgtggcgcc ggtgatgccg gccacgatgc gtccggcgta gaggatcgag 6780
atcgatctcg atcccgcgaa attaatacga ctcactata                        6819


<210> 192
<211> 6802
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 scFab deltaC2Cys19 construct

<400> 192
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaacgtacc 5460
gttgctgctc cgtctgtttt catcttcccg ccgtctgacg aacagctgaa atctggtacc 5520
gcttctgttg tttgcctgct gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa 5580
gttgacaacg ctctgcagtc tggtaactct caggaatctg ttaccgaaca ggactctaaa 5640
gactctacct actctctgtc ttctaccctg accctgtcta aagctgacta cgaaaagcac 5700
aaagtttacg cttgcgaagt tacccaccag ggtctgtctt ctccggttac caaatctttc 5760
aaccgtggtg aatctggtgg tggatccggt ggcggcagcg aaggtggtgg cagcgaaggt 5820
ggcggtagcg aaggtggcgg cagcgaaggc ggcggtagcg gtgggagctc cggtgaagtt 5880
cagctggttg aatctggtgg tggtctggtt aaagctggtg gttctctgtg cctgtcttgc 5940
ggtgtttcta acttccgtat ctctgctcac accatgaact gggttcgtcg tgttccgggt 6000
ggtggtctgg aatgggttgc ttctatctct acctcttcta cctaccgtga ctacgctgac 6060
gctgttaaag gtcgtttcac cgtttctcgt gacgacctgg aagacttcgt ttacctgcag 6120
atgcacaaaa tgcgtgttga agacaccgct atctactact gcgctcgtaa aggttctgac 6180
cgtctgtctg acaacgaccc gttcgacgct tggggtccgg gtaccgttgt taccgtttct 6240
ccggcgtcga ccaaaggtcc gtctgttttc ccgctggctc cgtcttctaa atctacctct 6300
ggtggtaccg ctgctctggg ttgcctggtt aaagactact tcccggaacc ggttaccgtt 6360
tcttggaact ctggtgctct gacctctggt gttcacacct tcccggctgt tctgcagtct 6420
tctggtctgt actctctgtc ttctgttgtt accgttccgt cttcttctct gggtacccag 6480
acctacatct gcaacgttaa ccacaaaccg tctaacacca aagttgacaa gaaagttgaa 6540
ccgaaatctg gcagcagcgg ccaggccggc cagcaccatc accatcacca tggcgcatac 6600
ccgtacgacg ttccggacta cgcttcttag gcggccgcac tcgagcacca ccaccaccac 6660
cactgagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct 6720
gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg 6780
aaaggaggaa ctatatccgg at                                          6802


<210> 193
<211> 6121
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 scFv Cys19 construct

<400> 193
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgtgcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgggc 5880
caggccggcc agcaccatca ccatcaccat ggcgcatacc cgtacgacgt tccggactac 5940
gcttcttagg cggccgcact cgagcaccac caccaccacc actgagatcc ggctgctaac 6000
aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc 6060
cttggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga 6120
t                                                                 6121


<210> 194
<211> 3513
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL A1

<400> 194
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gcctaactct ggctggtttc gctaccgtaa ccggtttaat taataaggag gatataatta 2280
tgaaaaagac agctatcgcg attgcagtgg cactggctgg tttcgctacc gtagcccagg 2340
cggccgcacg cgtctggttg aatctggtgg ggtctggaat tctgcgatcg cggccaggcc 2400
ggccgcacca tcaccatcac catggcgcat acccgtacga cgttccggac tacgcttcta 2460
ctagttagaa gggtggtggc tctgagggtg gcggttctga gggtggcggc tctgagggag 2520
gcggttccgg tggtggctct ggttccggtg attttgatta tgaaaagatg gcaaacgcta 2580
ataagggggc tatgaccgaa aatgccgatg aaaacgcgct acagtctgac gctaaaggca 2640
aacttgattc tgtcgctact gattacggtg ctgctatcga tggtttcatt ggtgacgttt 2700
ccggccttgc taatggtaat ggtgctactg gtgattttgc tggctctaat tcccaaatgg 2760
ctcaagtcgg tgacggtgat aattcacctt taatgaataa tttccgtcaa tatttacctt 2820
ccctccctca atcggttgaa tgtcgccctt ttgtctttgg cgctggtaaa ccatatgaat 2880
tttctattga ttgtgacaaa ataaacttat tccgtggtgt ctttgcgttt cttttatatg 2940
ttgccacctt tatgtatgta ttttctacgt ttgctaacat actgcgtaat aaggagtctt 3000
aagctagcta acgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg 3060
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca 3120
cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc 3180
gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct 3240
ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg 3300
ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc 3360
ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg 3420
attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg 3480
aattttaaca aaatattaac gcttacaatt tag                              3513

<210> 195
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3-ALA 2G12 pCAL G13

<400> 195
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtgcggcg gacgcggacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 196
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3-ALA LC 2G12 pCAL G13

<400> 196
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcacgcg gctggtgcgg cggctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 197
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL A1

<400> 197
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
aagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 198
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223> M13 gene III protein (cp3; g3p; minor coat
      protein; g.i. 59799327)

<400> 198
Met Lys Lys Leu Leu Phe Ala Ile Pro Leu Val Val Pro Phe Tyr Ser
 1               5                  10                  15      
His Ser Ala Glu Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu
            20                  25                  30          
Asn Ser Phe Thr Asn Val Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr
        35                  40                  45              
Ala Asn Tyr Glu Gly Cys Leu Trp Asn Ala Thr Gly Val Val Val Cys
    50                  55                  60                  
Thr Gly Asp Glu Thr Gln Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu
65                  70                  75                  80  
Ala Ile Pro Glu Asn Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu
                85                  90                  95      
Gly Gly Gly Ser Glu Gly Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp
            100                 105                 110         
Thr Pro Ile Pro Gly Tyr Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr
        115                 120                 125             
Pro Pro Gly Thr Glu Gln Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu
    130                 135                 140                 
Glu Ser Gln Pro Leu Asn Thr Phe Met Phe Gln Asn Asn Arg Phe Arg
145                 150                 155                 160 
Asn Arg Gln Gly Ala Leu Thr Val Tyr Thr Gly Thr Val Thr Gln Gly
                165                 170                 175     
Thr Asp Pro Val Lys Thr Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys
            180                 185                 190         
Ala Met Tyr Asp Ala Tyr Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe
        195                 200                 205             
His Ser Gly Phe Asn Glu Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln
    210                 215                 220                 
Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly
225                 230                 235                 240 
Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
                245                 250                 255     
Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly
            260                 265                 270         
Ser Gly Asp Phe Asp Tyr Glu Lys Met Ala Asn Ala Asn Lys Gly Ala
        275                 280                 285             
Met Thr Glu Asn Ala Asp Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly
    290                 295                 300                 
Lys Leu Asp Ser Val Ala Thr Asp Tyr Gly Ala Ala Ile Asp Gly Phe
305                 310                 315                 320 
Ile Gly Asp Val Ser Gly Leu Ala Asn Gly Asn Gly Ala Thr Gly Asp
                325                 330                 335     
Phe Ala Gly Ser Asn Ser Gln Met Ala Gln Val Gly Asp Gly Asp Asn
            340                 345                 350         
Ser Pro Leu Met Asn Asn Phe Arg Gln Tyr Leu Pro Ser Leu Pro Gln
        355                 360                 365             
Ser Val Glu Cys Arg Pro Phe Val Phe Ser Ala Gly Lys Pro Tyr Glu
    370                 375                 380                 
Phe Ser Ile Asp Cys Asp Lys Ile Asn Leu Phe Arg Gly Val Phe Ala
385                 390                 395                 400 
Phe Leu Leu Tyr Val Ala Thr Phe Met Tyr Val Phe Ser Thr Phe Ala
                405                 410                 415     
Asn Ile Leu Arg Asn Lys Glu Ser
            420                 


<210> 199
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF1

<400> 199
gccgctgtgc catcgctcag taaccaattg aattaaggag ga                    42

<210> 200
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR1

<400> 200
ggcggcgctc ttctagcgaa gtcgtcgaac tgcag                            35

<210> 201
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12ALACF2

<400> 201
gctacctacc actgccagca cgccgcgggt gcggccgcga ccttcggtca gggt       54

<210> 202
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12ALACR2

<400> 202
ggtaccctga ccgaaggtcg cggccgcacc cgcggcgtgc tggcagtggt aggt       54

<210> 203
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF3

<400> 203
ggcggcgctc ttctacccgt gttgaaatca aacgt                            35

<210> 204
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12IgGLC-F

<400> 204
ggtccctggc tcgagtgagg ttgttatgac ccagtctccg tc                    42

<210> 205
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12IgGLC-R

<400> 205
cctggtaccg aattcttagc attcaccacg gttgaaagat ttgg                  44

<210> 206
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HindIIILC-F1

<400> 206
gtaagcaagc ttatggacat gagagtgcct gcacagctgc tgggactgct gctgctgtgg 60
ctg                                                               63

<210> 207
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HindIIILC-F2

<400> 207
ggactgctgc tgctgtggct gccaggcgcc aagtgcgacg ttgttatgac ccagtctccg 60
tc                                                                62

<210> 208
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12EcoRILC-R

<400> 208
cgctacgaat tctcagcatt caccacggtt gaaagatttg gtaacc                46

<210> 209
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> pCALM 2G12 IgG Heavy Chain

<400> 209
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 210
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> pDR12 2G12 IgG Heavy Chain

<400> 210
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 211
<211> 6455
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCALM 8His

<400> 211
atgcattagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 60
gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 120
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 180
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 240
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 300
ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 360
tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc 420
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 480
tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag 540
gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc agatccgcta 600
gcgattacgc caagctcgaa attaaccctc actaaaggga acaaaagctg gagctccacc 660
gcggtggcgg ccgcccacca tggactggac ctggcggatc ctgttcctgg tggccgcggc 720
caccggagcc cacagcgaag ttcagctggt tgaatctggt ggtggtctgg ttaaagctgg 780
tggttctctg atcctgtctt gcggtgtttc taacttccgt atctctgctc acaccatgaa 840
ctgggttcgt cgtgttccgg gtggtggtct ggaatgggtt gcttctatct ctacctcttc 900
tacctaccgt gactacgctg acgctgttaa aggtcgtttc accgtttctc gtgacgacct 960
ggaagacttc gtttacctgc agatgcataa aatgcgtgtt gaagacaccg ctatctacta 1020
ctgcgctcgt aaaggttctg accgtctgtc tgacaacgac ccgttcgacg cttggggtcc 1080
gggtaccgtt gttaccgttt ctccggctag caccaagggc cccagcgtgt tccccctggc 1140
ccccagcagc aagagcacca gcggcggcac cgccgccctg ggctgcctgg tgaaggacta 1200
cttccccgag cccgtgaccg tgagctggaa cagcggcgcc ctgaccagcg gcgtgcacac 1260
cttccccgcc gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc 1320
cagcagcagc ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac 1380
caaggtggac aagaaggtgg agcccaagag ctgcgacaaa actcacacat gcccaccgtg 1440
cccagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga 1500
caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga 1560
agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac 1620
aaagccgcgg gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct 1680
gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc 1740
agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta 1800
caccctgccc ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt 1860
caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa 1920
caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa 1980
gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca 2040
tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaaggcgg 2100
gtctcatcac caccatcacc atcaccatgg cactagtcgg gccaagcggg cacccgtgaa 2160
gcagaccctg aacttcgacc tgctgaagct ggccggcgac gtggagagca accccggccc 2220
catgaggctc cctgctcagc tcctggggct gctaatgctc tgggtccctg gctcgagtga 2280
ggttgttatg acccagtctc cgtctaccct gtctgcttct gttggtgaca ccatcaccat 2340
cacctgccgt gcttctcagt ctatcgaaac ctggctggct tggtaccagc agaaaccggg 2400
taaagctccg aaactgctga tctacaaggc ttctaccctg aaaaccggtg ttccgtctcg 2460
tttctctggt tctggttctg gtaccgagtt caccctgacc atctctggtc tgcagttcga 2520
cgacttcgct acctaccact gccagcacta cgctggttac tctgctacct tcggtcaggg 2580
tacccgtgtt gaaatcaaac gtaccgttgc tgctccgtct gttttcatct tcccgccgtc 2640
tgacgaacag ctgaaatctg gtaccgcttc tgttgtttgc ctgctgaaca acttctaccc 2700
gcgtgaagct aaagttcagt ggaaagttga caacgctctg cagtctggta actctcagga 2760
atctgttacc gaacaggact ctaaagactc tacctactct ctgtcttcta ccctgaccct 2820
gtctaaagct gactacgaaa agcacaaagt ttacgcttgc gaagttaccc accagggtct 2880
gtcttctccg gttaccaaat ctttcaaccg tggtgaatgc taagaattcg gtaccaggta 2940
agtgtaccca attcgcccta tagtgagtcg tattacaatt cactcgatcg cccttcccaa 3000
cagttgcgca gcctgaatgg cgaatggaga tccaattttt aagtgtataa tgtgttaaac 3060
tactgattct aattgtttgt gtattttaga ttcacagtcc caaggctcat ttcaggcccc 3120
tcagtcctca cagtctgttc atgatcataa tcagccatac cacatttgta gaggttttac 3180
ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 3240
ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 3300
atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 3360
atgtatctta acgcgtaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt 3420
tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca 3480
aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta 3540
aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta 3600
cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg 3660
aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga 3720
aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg 3780
ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtcaggtggc 3840
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 3900
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 3960
aatcctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt ggaaagtccc 4020
caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt 4080
gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt 4140
cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg 4200
cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct 4260
cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca 4320
aagatcgatc aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac 4380
gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca 4440
atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt 4500
gtcaagaccg acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg 4560
tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga 4620
agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct 4680
cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg 4740
gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg 4800
gaagccggtc ttgtcgatca ggatgatctg gacgaagaac atcaggggct cgcgccagcc 4860
gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat 4920
ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac 4980
tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt 5040
gctgaagaac ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct 5100
cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc 5160
tggggttcga aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca 5220
ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga 5280
tcctccagcg cggggatctc atgctggagt tcttcgccca ccctaggggg aggctaactg 5340
aaacacggaa ggagacaata ccggaaggaa cccgcgctat gacggcaata aaaagacaga 5400
ataaaacgca cggtgttggg tcgtttgttc ataaacgcgg ggttcggtcc cagggctggc 5460
actctgtcga taccccaccg agaccccatt ggggccaata cgcccgcgtt tcttcctttt 5520
ccccacccca ccccccaagt tcgggtgaag gcccagggct cgcagccaac gtcggggcgg 5580
caggccctgc catagcctca ggttactcat atatacttta gattgattta aaacttcatt 5640
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 5700
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 5760
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 5820
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 5880
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 5940
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 6000
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 6060
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 6120
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 6180
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 6240
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 6300
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 6360
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 6420
tatcccctga ttctgtggat aaccgtatta ccgcc                            6455


<210> 212
<211> 13309
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pDR12

<400> 212
attgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 60
acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 120
tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 180
tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 240
gatctagctt cgtgtcaagg acggtgactg cagtgaataa taaaatgtgt gtttgtccga 300
aatacgcgtt ttgagatttc tgtcgccgac taaattcatg tcgcgcgata gtggtgttta 360
tcgccgatag agatggcgat attggaaaaa tcgatatttg aaaatatggc atattgaaaa 420
tgtcgccgat gtgagtttct gtgtaactga tatcgccatt tttccaaaag tgatttttgg 480
gcatacgcga tatctggcga tagcgcttat atcgtttacg ggggatggcg atagacgact 540
ttggtgactt gggcgattct gtgtgtcgca aatatcgcag tttcgatata ggtgacagac 600
gatatgaggc tatatcgccg atagaggcga catcaagctg gcacatggcc aatgcatatc 660
gatctataca ttgaatcaat attggccatt agccatatta ttcattggtt atatagcata 720
aatcaatatt ggctattggc cattgcatac gttgtatcca tatcataata tgtacattta 780
tattggctca tgtccaacat taccgccatg ttgacattga ttattgacta gttattaata 840
gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact 900
tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat 960
gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta 1020
tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc 1080
tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg 1140
ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg 1200
gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct 1260
ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa 1320
atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt 1380
ctatataagc acagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg 1440
ttttgacctc catagaagac accgggaccg atccagcctc cgcggccggg aacggtgcat 1500
tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag tctataggcc 1560
cacccccttg gcttcttatg catgctatac tgtttttggc ttggggtcta tacacccccg 1620
cttcctcatg ttataggtga tggtatagct tagcctatag gtgtgggtta ttgaccatta 1680
ttgaccactc ccctattggt gacgatactt tccattacta atccataaca tggctctttg 1740
ccacaactct ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact 1800
ctgtattttt acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac 1860
cgtccccagt gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg 1920
tacgtgttcc ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg 1980
ctcccatgcc tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc 2040
cagacttagg cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt 2100
agggtatgtg tctgaaaatc agctcgggga gcgggcttgc accgctgacg catttggaag 2160
acttaaggca gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc 2220
agaggtaact cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact 2280
cgttgctgcc gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc 2340
catgggtctt ttctgcagtc accgtccttg acacgaagct ctagagccgc caccatggaa 2400
ctggggctcc gctgggtttt ccttgttgct attttagaag gtgtccagtg tgaggtgcag 2460
ctggtggagt ctgggggagg cctggtcaag gcgggaggat ccctcatact ctcctgtgga 2520
gtctctaatt ttagaatctc tgcccatacc atgaattggg tccgccgggt tccagggggg 2580
gggctggagt gggtcgcttc cattagtacg agttccactt atagagacta tgcagacgct 2640
gtgaagggcc gattcaccgt ttccagagac gacctcgaag actttgtgta tttgcaaatg 2700
cacaaaatga gagtcgaaga cacggctatt tattactgcg ccagaaaggg atctgacaga 2760
ctaagcgaca acgatccttt tgatgcctgg ggcccaggga cagtggtcac cgtctctccc 2820
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 2880
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 2940
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 3000
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 3060
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttggtgag 3120
aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac 3180
gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct gcctcttcac 3240
ccggaggcct ctgcccgccc cactcatgct cagggagagg gtcttctggc tttttcccca 3300
ggctctgggc aggcacaggc taggtgcccc taacccaggc cctgcacaca aaggggcagg 3360
tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg acctaagccc 3420
accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct cccagattcg 3480
agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc acacatgccc 3540
accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg acaggtgccc 3600
tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacacgtcc acctccatct 3660
cttcctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca 3720
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc 3780
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca 3840
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg 3900
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc 3960
tcccagcccc catcgagaaa accatctcca aagccaaagg tgggacccgt ggggtgcgag 4020
ggccacatgg acagaggccg gctcggccca ccctctgccc tgagagtgac cgctgtacca 4080
acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 4140
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 4200
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 4260
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 4320
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 4380
tacacgcaga agagcctctc cctgtctccg ggtaaatgag tgcgacggcc ggcaagcccc 4440
gctccccggg ctctcgcggt cgcacgagga tgcttggcac gtaccccctg tacatacttc 4500
ccgggcgccc agcatggaaa taaagcaccc agcgctgccc tgggcccctg cgagactgtg 4560
atggttcttt ccacgggtca ggccgagtct gaggcctgag tggcatgagg gaggcagagc 4620
gggtcccact gtccccacac tggcccaggc tgtgcaggtg tgcctgggcc ccctagggtg 4680
gggctcagcc aggggctgcc ctcggcaggg tgggggattt gccagcgtgg ccctccctcc 4740
agcagcacct gccctgggct gggccacggg aagccctagg agcccctggg gacagacaca 4800
cagcccctgc ctctgtagga gactgtcctg ttctgtgagc gcccctgtcc tcccgacctc 4860
catgcccact cgggggcatg cctagtccat gtgcgtaggg acaggccctc cctcacccat 4920
ctacccccac ggcactaacc cctggctgcc ctgcccagcc tcgcacccgc atggggacac 4980
aaccgactcc ggggacatgc actctcgggc cctgtggagg gactggtgca gatgcccaca 5040
cacacactca gcccagaccc gttcaacaaa ccccgcactg aggttggccg gccacacggc 5100
caccacacac acacgtgcac gcctcacaca cggagcctca cccgggcgaa ctgcacagca 5160
cccagaccag agcaaggtcc tcgcacacgt gaacactcct cggacacagg cccccacgag 5220
ccccacgcgg cacctcaagg cccacgagcc tctcggcagc ttctccacat gctgacctgc 5280
tcagacaaac ccagccctcc tctcacaagg gtgcccctgc agccgccaca cacacacagg 5340
ggatcacaca ccacgtcacg tccctggccc tggcccactt cccagtgccg cccttccctg 5400
cagacggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 5460
cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 5520
tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 5580
atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 5640
ctggatcaga tcctctacgc cggacgcatc gtggccggca tcaccggcgc cacaggtgcg 5700
gttgctggcg cctatatcgc cgacatcacc gatggggaag atcgggctcg ccacttcggg 5760
ctcatgagcg cttgtttcgg cgtgggtatg gtggcaggcc cgtggccggg ggactgttgg 5820
gcgccatctc cttgcatgca ccattccttg cggcggcggt gctcaacggc ctcaacctac 5880
tactgggctg cttcctaatg caggagtcgc ataagggaga gcgtcgacct cgggccgcgt 5940
tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 6000
gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 6060
ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 6120
cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg 6180
tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 6240
tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 6300
cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 6360
agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga 6420
agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 6480
gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 6540
aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 6600
ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 6660
gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 6720
taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 6780
tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 6840
tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 6900
gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 6960
gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 7020
ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 7080
cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 7140
tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 7200
cagcactgca tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact 7260
caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa 7320
cacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt 7380
cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca 7440
ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa 7500
aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac 7560
tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg 7620
gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc 7680
gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata 7740
ggcgtatcac gaggccctga tggctctttg cggcacccat cgttcgtaat gttccgtggc 7800
accgaggaca accctcaaga gaaaatgtaa tcacactggc tcaccttcgg gtgggccttt 7860
ctgcgtttat aaggagacac tttatgttta agaaggttgg taaattcctt gcggctttgg 7920
cagccaagct agatccggct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc 7980
tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggctcccc 8040
agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct 8100
aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg 8160
actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa 8220
gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aacctagctt ggggccaccg 8280
ctcagagcac cttccaccat ggccacctca gcaagttccc acttgaacaa aaacatcaag 8340
caaatgtact tgtgcctgcc ccagggtgag aaagtccaag ccatgtatat ctgggttgat 8400
ggtactggag aaggactgcg ctgcaaaacc cgcaccctgg actgtgagcc caagtgtgta 8460
gaagagttac ctgagtggaa ttttgatggc tctagtacct ttcagtctga gggctccaac 8520
agtgacatgt atctcagccc tgttgccatg tttcgggacc ccttccgcag agatcccaac 8580
aagctggtgt tctgtgaagt tttcaagtac aaccggaagc ctgcagagac caatttaagg 8640
cactcgtgta aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa 8700
caggagtata ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt 8760
cctgggcccc aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat 8820
atcgtggagg ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat 8880
gctgaggtca tgcctgccca gtgggagttc caaataggac cctgtgaagg aatccgcatg 8940
ggagatcatc tctgggtggc ccgtttcatc ttgcatcgag tatgtgaaga ctttggggta 9000
atagcaacct ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc 9060
aactttagca ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc 9120
gagaaactaa gcaagcggca ccggtaccac attcgagcct acgatcccaa ggggggcctg 9180
gacaatgccc gtcgtctgac tgggttccac gaaacgtcca acatcaacga cttttctgct 9240
ggtgtcgcca atcgcagtgc cagcatccgc attccccgga ctgtcggcca ggagaagaaa 9300
ggttactttg aagaccgccg cccctctgcc aattgtgacc cctttgcagt gacagaagcc 9360
atcgtccgca catgccttct caatgagact ggcgacgagc ccttccaata caaaaactaa 9420
ttagactttg agtgatcttg agcctttcct agttcatccc accccgcccc agagagatct 9480
ttgtgaagga accttacttc tgtggtgtga cataattgga caaactacct acagagattt 9540
aaagctctaa ggtaaatata aaatttttaa gtgtataatg tgttaaacta ctgattctaa 9600
ttgtttgtgt attttagatt ccaacctatg gaactgatga atgggagcag tggtggaatg 9660
cctttaatga ggaaaacctg ttttgctcag aagaaatgcc atctagtgat gatgaggcta 9720
ctgctgactc tcaacattct actcctccaa aaaagaagag aaaggtagaa gaccccaagg 9780
actttccttc agaattgcta agttttttga gtcatgctgt gtttagtaat agaactcttg 9840
cttgctttgc tatttacacc acaaaggaaa aagctgcact gctatacaag aaaattatgg 9900
aaaaatattc tgtaaccttt ataagtaggc ataacagtta taatcataac atactgtttt 9960
ttcttactcc acacaggcat agagtgtctg ctattaataa ctatgctcaa aaattgtgta 10020
cctttagctt tttaatttgt aaaggggtta ataaggaata tttgatgtat agtgccttga 10080
ctagagatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 10140
ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 10200
attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 10260
tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 10320
tggatctagc ttcgtgtcaa ggacggtgac tgcagtgaat aataaaatgt gtgtttgtcc 10380
gaaatacgcg ttttgagatt tctgtcgccg actaaattca tgtcgcgcga tagtggtgtt 10440
tatcgccgat agagatggcg atattggaaa aatcgatatt tgaaaatatg gcatattgaa 10500
aatgtcgccg atgtgagttt ctgtgtaact gatatcgcca tttttccaaa agtgattttt 10560
gggcatacgc gatatctggc gatagcgctt atatcgttta cgggggatgg cgatagacga 10620
ctttggtgac ttgggcgatt ctgtgtgtcg caaatatcgc agtttcgata taggtgacag 10680
acgatatgag gctatatcgc cgatagaggc gacatcaagc tggcacatgg ccaatgcata 10740
tcgatctata cattgaatca atattggcca ttagccatat tattcattgg ttatatagca 10800
taaatcaata ttggctattg gccattgcat acgttgtatc catatcataa tatgtacatt 10860
tatattggct catgtccaac attaccgcca tgttgacatt gattattgac tagttattaa 10920
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 10980
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 11040
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 11100
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 11160
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 11220
tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 11280
cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt 11340
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 11400
aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag 11460
gtctatataa gcacagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc 11520
tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc 11580
attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag agtctatagg 11640
cccaccccct tggcttctta tgcatgctat actgtttttg gcttggggtc tatacacccc 11700
cgcttcctca tgttataggt gatggtatag cttagcctat aggtgtgggt tattgaccat 11760
tattgaccac tcccctattg gtgacgatac tttccattac taatccataa catggctctt 11820
tgccacaact ctctttattg gctatatgcc aatacactgt ccttcagaga ctgacacgga 11880
ctctgtattt ttacaggatg gggtctcatt tattatttac aaattcacat atacaacacc 11940
accgtcccca gtgcccgcag tttttattaa acataacgtg ggatctccac gcgaatctcg 12000
ggtacgtgtt ccggacatgg gctcttctcc ggtagcggcg gagcttctac atccgagccc 12060
tgctcccatg cctccagcga ctcatggtcg ctcggcagct ccttgctcct aacagtggag 12120
gccagactta ggcacagcac gatgcccacc accaccagtg tgccgcacaa ggccgtggcg 12180
gtagggtatg tgtctgaaaa tcagctcggg gagcgggctt gcaccgctga cgcatttgga 12240
agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtgtt ctgataagag 12300
tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta 12360
ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt 12420
tccatgggtc ttttctgcag tcaccgtcct tgacacgaag cttaccatgg acatgagggt 12480
ccccgctcag ctcctggggc tcctgctgct ctggctccca ggtaaggaag gagaacacta 12540
ggaatttact cagcccagtg tgctcagtac tgcctggtta ttcagggaag tcttcctata 12600
atatgatcaa tagtatgaat atttgtgttt ctatttccaa tctcaggtgc caaatgtgat 12660
gttgtgatga ctcagtctcc ttccaccctg tctgcatctg tcggagacac aatcaccatc 12720
acttgccggg ccagtcagag tattgaaacc tggttggcct ggtatcagca gaagccaggg 12780
aaagccccaa aactcctaat ctacaaggcg tctactttaa aaactggagt cccgtcaaga 12840
ttcagcggca gtggatctgg aacagagttc actcttacca tcagtggcct gcagttcgat 12900
gactttgcaa cttatcactg tcagcactat gctggttatt cagccacttt tggccaggga 12960
accagggtgg agatcaaacg tactgtggct gcaccatctg tcttcatctt cccgccatct 13020
gatgagcagt tgaaatctgg gactgcctct gttgtgtgcc tgctgaataa cttctatccc 13080
agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 13140
agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgttg 13200
agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 13260
agttcgcccg tcacaaagag cttcaacagg ggagagtgtt aatgaattc             13309


<210> 213
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF1

<400> 213
gccgctgtgc catcgctcag taaccaattg aattaaggag ga                    42

<210> 214
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> QHYA-R

<400> 214
gcagtggtag gtagcgaagt cgtc                                        24

<210> 215
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 REFERENCE qhya

<400> 215
gacgacttcg cgacctacca ctgccagcac tacgctggtt actctgctac cttcggtcag 60
ggtacccgtg                                                        70

<210> 216
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> LCDR3-QHYA5'

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35
<223> n = a, c, t or g

<220> 
<221> variation      
<222> 27, 30, 33, 36
<223> k = g or t

<400> 216
gacgacttcg cgacctacca ctgcnnknnk nnknnkggtt actctgctac cttcggtcag 60
ggtacccgtg                                                        70

<210> 217
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR3

<400> 217
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 218
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 218
Gln His Tyr Arg Glu Trp Arg Ala Thr
 1               5                  


<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 219
Gln His Tyr Arg Glu Phe Asn Ala Thr
 1               5                  


<210> 220
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 220
Gln His Tyr Arg Glu Phe His Ala Thr
 1               5                  


<210> 221
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 221
Gln His Tyr Arg Pro Trp Ser Ala Thr
 1               5                  


<210> 222
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 222
Gln His Tyr Met Pro Phe Asn Ala Ser
 1               5                  


<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 223
Gln His Tyr Ile Pro Phe Glu Ala Thr
 1               5                  


<210> 224
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 224
Gln His Tyr Leu Pro Phe Gln Ala Thr
 1               5                  


<210> 225
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 225
Gln His Tyr Ile Pro Phe Ser Ala Thr
 1               5                  


<210> 226
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 226
Gln His Tyr Gln Pro Phe His Ala Thr
 1               5                  


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 227
Gln His Tyr Gln Pro Phe Arg Ala Thr
 1               5                  


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 228
Gln His Tyr Val Pro Phe Lys Ala Thr
 1               5                  


<210> 229
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 229
Gln His Tyr Leu Pro Phe Lys Ala Thr
 1               5                  


<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 230
Gln His Tyr Lys Pro Phe Trp Ala Thr
 1               5                  


<210> 231
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 231
Gln His Tyr Gln Pro Phe Val Ala Thr
 1               5                  


<210> 232
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 232
Gln His Tyr Arg Pro Trp Trp Ala Thr
 1               5                  


<210> 233
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 233
Gln His Tyr Leu Pro Trp Trp Ala Thr
 1               5                  


<210> 234
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 234
Gln His Tyr Met Pro Tyr Ser Ala Thr
 1               5                  


<210> 235
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 235
Gln His Tyr Gln Pro Tyr Ser Ala Thr
 1               5                  


<210> 236
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 236
Gln His Tyr Glu Pro Tyr Val Ala Thr
 1               5                  


<210> 237
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 237
Gln His Tyr Met Pro Tyr Lys Ala Thr
 1               5                  


<210> 238
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 238
Gln His Tyr Met Pro Tyr Asn Ala Thr
 1               5                  


<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 239
Gln His Tyr Gln Pro Tyr Asn Ala Thr
 1               5                  


<210> 240
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 240
Gln His Tyr Leu Pro Tyr Asn Ala Ser
 1               5                  


<210> 241
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 241
Gln His Tyr Ser Pro Tyr Trp Ala Thr
 1               5                  


<210> 242
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 242
Gln His Tyr Leu Pro Tyr Glu Ala Ser
 1               5                  


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 243
Gln His Tyr Glu Pro Tyr Leu Ala Thr
 1               5                  


<210> 244
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 244
Gln His Tyr Leu Pro Phe Gly Ala Ser
 1               5                  


<210> 245
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 245
Gln His Tyr Lys Asp Phe Ser Ala Thr
 1               5                  


<210> 246
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 246
Gln His Tyr Met Ala Tyr Gln Ala Thr
 1               5                  


<210> 247
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 247
Gln His Tyr Gln Ala Phe Asn Ala Thr
 1               5                  


<210> 248
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 248
Asn Pro Leu Ser Gly Tyr Ser Ala Thr
 1               5                  


<210> 249
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 249
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 250
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 250
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 251
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 251
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 252
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 252
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 253
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 253
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asn
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 254
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 254
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 255
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 255
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 256
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 256
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 257
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 257
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 258
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 258
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 259
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 259
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 260
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 260
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 261
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 261
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 262
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 262
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Val
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 263
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 263
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 264
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 264
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 265
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 265
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 266
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 266
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 267
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 267
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Val
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 268
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 268
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 269
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 269
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 270
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 270
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 271
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 271
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Asn
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 272
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 272
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Pro Tyr Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 273
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 273
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Glu
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 274
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 274
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Leu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 275
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 275
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Gly
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 276
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 276
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Asp Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 277
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 277
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Ala Tyr Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 278
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 278
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Ala Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 279
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 279
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Asn Pro Leu Ser Gly Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 280
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDR3

<400> 280
Gln His Tyr Lys Pro Phe Ser Ala Thr
 1               5                  


<210> 281
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDR3

<400> 281
Gln His Tyr Met Pro Phe Arg Ala Thr
 1               5                  


<210> 282
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 282
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 283
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 283
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 284
<211> 330
<212> PRT
<213> Homo sapiens

<220> 
<223> Constant region heavy chain IgG1

<400> 284
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 285
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> DraIIICmR-F1

<400> 285
ggtgatggtt cacgtagtgg gccatc                                      26

<210> 286
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> CmR-R1

<400> 286
tatccagtga tttttttctc catactcttc ctttttcaat attattgaag c          51

<210> 287
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> CmR-F2

<400> 287
gcttcaataa tattgaaaaa ggaagagtat ggagaaaaaa atcactggat a          51

<210> 288
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> CmR-R2

<400> 288
gtatatatga gtaaacttgg tctgacagtt acgccccgcc ctgccactc             49

<210> 289
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> CmR-F3

<400> 289
gagtggcagg gcggggcgta actgtcagac caagtttact catatatac             49

<210> 290
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> PciICmR-R3

<400> 290
cgcaggaaag aacatgtgag caaaagg                                     27

<210> 291
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> MfeILCbla-F1

<400> 291
gtgagcggat aacaattgaa ttaaggag                                    28

<210> 292
<211> 87
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXLC**bla-R1

<400> 292
cagaaccacc accgctgcca ccaccgcatt caccacggtt gaaagatttg gtaaccggag 60
agctcagtta ttagtgggta acttcgc                                     87

<210> 293
<211> 87
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXLCbla-R1

<400> 293
cagaaccacc accgctgcca ccaccgcatt caccacggtt gaaagatttg gtaaccggag 60
agctcagacc ctggtgggta acttcgc                                     87

<210> 294
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> LCbla-F2

<400> 294
ggtggtggca gcggtggtgg ttctggtggc ggtagcggcg gtggctctca cccagaaacg 60
ctggtg                                                            66

<210> 295
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> PacILCbla-R2

<400> 295
cgccgccgtt aattaattat taccaatgct taatcagtga ggcac                 45

<210> 296
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12VH-F

<400> 296
gtagcctagg cggccgcaga agttc                                       25

<210> 297
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXHC**bla-R1

<400> 297
gacggacctt tggtcgacgc ttattaaacg gtaacaacgg tacc                  44

<210> 298
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXHC**bla-F2

<400> 298
ggtaccgttg ttaccgttta ataagcgtcg accaaaggtc cgtc                  44

<210> 299
<211> 52
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXHCbla-R2

<400> 299
cagaaccacc accgctgcca ccaccgcaag atttcggttc aactttcttg tc         52

<210> 300
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXHisHAHCbla-R2

<400> 300
cagaaccacc accgctgcca ccaccagaag cgtagtccgg aacgtcgtac            50

<210> 301
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCbla-R3

<400> 301
cgccgccggc tagcttacca atgcttaatc agtgaggcac                       40

<210> 302
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> MfeILCbla-F1

<400> 302
gtgagcggat aacaattgaa ttaaggag                                    28

<210> 303
<211> 79
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXLCSacIPacI-R1

<400> 303
cctccttatt aattaattag cattcaccac ggttgaaaga tttggtaacc ggagagctca 60
gaccctggtg ggtaacttc                                              79

<210> 304
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Seq2G12CK-F

<400> 304
ctgaccctgt ctaaagctga c                                           21

<210> 305
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALMfeI-F

<400> 305
gttagctcac tcattaggca c                                           21

<210> 306
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALOmpA-R

<400> 306
ctaggctacg gtagcgaaac                                             20

<210> 307
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Seq2G12CH-F

<400> 307
ccagacctac atctgcaacg                                             20

<210> 308
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALNheI-R

<400> 308
caagtgtagc ggtcacgctg                                             20

<210> 309
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALOmpA-F

<400> 309
gatataatta tgaaaaagac                                             20

<210> 310
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALDraIII-F

<400> 310
ccccgtcaag ctctaaatcg                                             20

<210> 311
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALPciI-R

<400> 311
gcttcctcgc tcactgactc                                             20

<210> 312
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqCmR-F

<400> 312
gaccgttcag ctggatatta c                                           21

<210> 313
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqCmR-R

<400> 313
ggtgctacag agttcttgaa g                                           21

<210> 314
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12Asp-R

<400> 314
ctgggtcata acaacatcgg ccatggccgg ctag                             34

<210> 315
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12DIQ-R

<400> 315
ggagactggg tcatctggat atcggccatg gccggctag                        39

<210> 316
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12Asp-F

<400> 316
ctagccggcc atggccgatg ttgttatgac ccag                             34

<210> 317
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12DIQ-F

<400> 317
ctagccggcc atggccgata tccagatgac ccagtctcc                        39

<210> 318
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12CKSacI-R

<400> 318
cggttgaaag atttggtaac cggagagc                                    28

<210> 319
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> AGVV

<400> 319
Ala Gly Val Val
 1              


<210> 320
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 320
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      


<210> 321
<211> 5978
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 LC bla pCAL IT* CmR (2G12 LC bla)

<400> 321
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccaccag ggtctgagct ctccggttac caaatctttc aaccgtggtg aatgcggtgg 3780
tggcagcggt ggtggttctg gtggcggtag cggcggtggc tctcacccag aaacgctggt 3840
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 3900
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 3960
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 4020
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 4080
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 4140
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 4200
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 4260
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 4320
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 4380
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 4440
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 4500
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 4560
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaataatt 4620
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 4680
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 4740
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 4800
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4860
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4920
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4980
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 5040
cgacgcttgg ggtccgggta ccgttgttac cgtttctccg gcgtcgacca aaggtccgtc 5100
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 5160
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 5220
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 5280
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 5340
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 5400
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 5460
cgcttctact agctaacgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 5520
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 5580
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 5640
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 5700
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 5760
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 5820
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 5880
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 5940
acgcgaattt taacaaaata ttaacgctta caatttag                         5978


<210> 322
<211> 5975
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 DVV LC bla pCAL IT* CmR (2G12 DVV LC bla)

<400> 322
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gatgttgtta tgacccagtc tccgtctacc ctgtctgctt ctgttggtga 3180
caccatcacc atcacctgcc gtgcttctca gtctatcgaa acctggctgg cttggtacca 3240
gcagaaaccg ggtaaagctc cgaaactgct gatctacaag gcttctaccc tgaaaaccgg 3300
tgttccgtct cgtttctctg gttctggttc tggtaccgag ttcaccctga ccatctctgg 3360
tctgcagttc gacgacttcg ctacctacca ctgccagcac tacgctggtt actctgctac 3420
cttcggtcag ggtacccgtg ttgaaatcaa acgtaccgtt gctgctccgt ctgttttcat 3480
cttcccgccg tctgacgaac agctgaaatc tggtaccgct tctgttgttt gcctgctgaa 3540
caacttctac ccgcgtgaag ctaaagttca gtggaaagtt gacaacgctc tgcagtctgg 3600
taactctcag gaatctgtta ccgaacagga ctctaaagac tctacctact ctctgtcttc 3660
taccctgacc ctgtctaaag ctgactacga aaagcacaaa gtttacgctt gcgaagttac 3720
ccaccagggt ctgagctctc cggttaccaa atctttcaac cgtggtgaat gcggtggtgg 3780
cagcggtggt ggttctggtg gcggtagcgg cggtggctct cacccagaaa cgctggtgaa 3840
agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 3900
cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 3960
taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 4020
tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 4080
tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 4140
cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 4200
gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 4260
cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 4320
actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 4380
ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 4440
tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 4500
tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 4560
acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aataattaat 4620
taataaggag gatataatta tgaaaaagac agctatcgcg attgcagtgg cactggctgg 4680
tttcgctacc gtagcctagg cggccgcaga agttcagctg gttgaatctg gtggtggtct 4740
ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt tctaacttcc gtatctctgc 4800
tcacaccatg aactgggttc gtcgtgttcc gggtggtggt ctggaatggg ttgcttctat 4860
ctctacctct tctacctacc gtgactacgc tgacgctgtt aaaggtcgtt tcaccgtttc 4920
tcgtgacgac ctggaagact tcgtttacct gcagatgcat aaaatgcgtg ttgaagacac 4980
cgctatctac tactgcgctc gtaaaggttc tgaccgtctg tctgacaacg acccgttcga 5040
cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg tcgaccaaag gtccgtctgt 5100
tttcccgctg gctccgtctt ctaaatctac ctctggtggt accgctgctc tgggttgcct 5160
ggttaaagac tacttcccgg aaccggttac cgtttcttgg aactctggtg ctctgacctc 5220
tggtgttcac accttcccgg ctgttctgca gtcttctggt ctgtactctc tgtcttctgt 5280
tgttaccgtt ccgtcttctt ctctgggtac ccagacctac atctgcaacg ttaaccacaa 5340
accgtctaac accaaagttg acaagaaagt tgaaccgaaa tcttgcctgc gatcgcggcc 5400
aggccggccg caccatcacc atcaccatgg cgcatacccg tacgacgttc cggactacgc 5460
ttctactagc taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 5520
cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 5580
cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 5640
tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 5700
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 5760
cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 5820
tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 5880
ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 5940
cgaattttaa caaaatatta acgcttacaa tttag                            5975


<210> 323
<211> 5975
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 DIQ LC bla pCAL IT* CmR (2G12 DIQ LC bla)

<400> 323
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gatatccaga tgacccagtc tccgtctacc ctgtctgctt ctgttggtga 3180
caccatcacc atcacctgcc gtgcttctca gtctatcgaa acctggctgg cttggtacca 3240
gcagaaaccg ggtaaagctc cgaaactgct gatctacaag gcttctaccc tgaaaaccgg 3300
tgttccgtct cgtttctctg gttctggttc tggtaccgag ttcaccctga ccatctctgg 3360
tctgcagttc gacgacttcg ctacctacca ctgccagcac tacgctggtt actctgctac 3420
cttcggtcag ggtacccgtg ttgaaatcaa acgtaccgtt gctgctccgt ctgttttcat 3480
cttcccgccg tctgacgaac agctgaaatc tggtaccgct tctgttgttt gcctgctgaa 3540
caacttctac ccgcgtgaag ctaaagttca gtggaaagtt gacaacgctc tgcagtctgg 3600
taactctcag gaatctgtta ccgaacagga ctctaaagac tctacctact ctctgtcttc 3660
taccctgacc ctgtctaaag ctgactacga aaagcacaaa gtttacgctt gcgaagttac 3720
ccaccagggt ctgagctctc cggttaccaa atctttcaac cgtggtgaat gcggtggtgg 3780
cagcggtggt ggttctggtg gcggtagcgg cggtggctct cacccagaaa cgctggtgaa 3840
agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 3900
cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 3960
taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 4020
tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 4080
tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 4140
cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 4200
gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 4260
cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 4320
actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 4380
ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 4440
tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 4500
tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 4560
acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aataattaat 4620
taataaggag gatataatta tgaaaaagac agctatcgcg attgcagtgg cactggctgg 4680
tttcgctacc gtagcctagg cggccgcaga agttcagctg gttgaatctg gtggtggtct 4740
ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt tctaacttcc gtatctctgc 4800
tcacaccatg aactgggttc gtcgtgttcc gggtggtggt ctggaatggg ttgcttctat 4860
ctctacctct tctacctacc gtgactacgc tgacgctgtt aaaggtcgtt tcaccgtttc 4920
tcgtgacgac ctggaagact tcgtttacct gcagatgcat aaaatgcgtg ttgaagacac 4980
cgctatctac tactgcgctc gtaaaggttc tgaccgtctg tctgacaacg acccgttcga 5040
cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg tcgaccaaag gtccgtctgt 5100
tttcccgctg gctccgtctt ctaaatctac ctctggtggt accgctgctc tgggttgcct 5160
ggttaaagac tacttcccgg aaccggttac cgtttcttgg aactctggtg ctctgacctc 5220
tggtgttcac accttcccgg ctgttctgca gtcttctggt ctgtactctc tgtcttctgt 5280
tgttaccgtt ccgtcttctt ctctgggtac ccagacctac atctgcaacg ttaaccacaa 5340
accgtctaac accaaagttg acaagaaagt tgaaccgaaa tcttgcctgc gatcgcggcc 5400
aggccggccg caccatcacc atcaccatgg cgcatacccg tacgacgttc cggactacgc 5460
ttctactagc taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 5520
cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 5580
cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 5640
tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 5700
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 5760
cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 5820
tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 5880
ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 5940
cgaattttaa caaaatatta acgcttacaa tttag                            5975


<210> 324
<211> 5978
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 HC bla pCAL IT* CmR (2G12 HC bla)

<400> 324
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccaccag ggtctgagct ctccggttac caaatctttc aaccgtggtg aatgctaatt 3780
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 3840
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 3900
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 3960
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4020
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4080
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4140
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 4200
cgacgcttgg ggtccgggta ccgttgttac cgtttctccg gcgtcgacca aaggtccgtc 4260
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 4320
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 4380
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 4440
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 4500
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 4560
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 4620
cgcttctggt ggtggcagcg gtggtggttc tggtggcggt agcggcggtg gctctcaccc 4680
agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 4740
cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 4800
aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 4860
gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 4920
agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 4980
aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 5040
gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 5100
ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 5160
aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 5220
aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 5280
tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc 5340
agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 5400
ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 5460
ttggtaagct agctaacgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 5520
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 5580
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 5640
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 5700
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 5760
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 5820
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 5880
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 5940
acgcgaattt taacaaaata ttaacgctta caatttag                         5978


<210> 325
<211> 5978
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 LC** bla pCAL IT* CmR (2G12 LC**bla)

<400> 325
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccactaa taactgagct ctccggttac caaatctttc aaccgtggtg aatgcggtgg 3780
tggcagcggt ggtggttctg gtggcggtag cggcggtggc tctcacccag aaacgctggt 3840
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 3900
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 3960
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 4020
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 4080
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 4140
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 4200
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 4260
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 4320
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 4380
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 4440
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 4500
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 4560
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaataatt 4620
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 4680
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 4740
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 4800
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4860
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4920
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4980
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 5040
cgacgcttgg ggtccgggta ccgttgttac cgtttctccg gcgtcgacca aaggtccgtc 5100
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 5160
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 5220
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 5280
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 5340
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 5400
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 5460
cgcttctact agctaacgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 5520
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 5580
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 5640
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 5700
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 5760
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 5820
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 5880
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 5940
acgcgaattt taacaaaata ttaacgctta caatttag                         5978


<210> 326
<211> 5975
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 DVV LC** bla pCAL IT* CmR (DX DVV LC** bla)

<400> 326
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gatgttgtta tgacccagtc tccgtctacc ctgtctgctt ctgttggtga 3180
caccatcacc atcacctgcc gtgcttctca gtctatcgaa acctggctgg cttggtacca 3240
gcagaaaccg ggtaaagctc cgaaactgct gatctacaag gcttctaccc tgaaaaccgg 3300
tgttccgtct cgtttctctg gttctggttc tggtaccgag ttcaccctga ccatctctgg 3360
tctgcagttc gacgacttcg ctacctacca ctgccagcac tacgctggtt actctgctac 3420
cttcggtcag ggtacccgtg ttgaaatcaa acgtaccgtt gctgctccgt ctgttttcat 3480
cttcccgccg tctgacgaac agctgaaatc tggtaccgct tctgttgttt gcctgctgaa 3540
caacttctac ccgcgtgaag ctaaagttca gtggaaagtt gacaacgctc tgcagtctgg 3600
taactctcag gaatctgtta ccgaacagga ctctaaagac tctacctact ctctgtcttc 3660
taccctgacc ctgtctaaag ctgactacga aaagcacaaa gtttacgctt gcgaagttac 3720
ccactaataa ctgagctctc cggttaccaa atctttcaac cgtggtgaat gcggtggtgg 3780
cagcggtggt ggttctggtg gcggtagcgg cggtggctct cacccagaaa cgctggtgaa 3840
agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 3900
cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 3960
taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 4020
tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 4080
tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 4140
cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 4200
gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 4260
cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 4320
actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 4380
ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 4440
tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 4500
tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 4560
acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aataattaat 4620
taataaggag gatataatta tgaaaaagac agctatcgcg attgcagtgg cactggctgg 4680
tttcgctacc gtagcctagg cggccgcaga agttcagctg gttgaatctg gtggtggtct 4740
ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt tctaacttcc gtatctctgc 4800
tcacaccatg aactgggttc gtcgtgttcc gggtggtggt ctggaatggg ttgcttctat 4860
ctctacctct tctacctacc gtgactacgc tgacgctgtt aaaggtcgtt tcaccgtttc 4920
tcgtgacgac ctggaagact tcgtttacct gcagatgcat aaaatgcgtg ttgaagacac 4980
cgctatctac tactgcgctc gtaaaggttc tgaccgtctg tctgacaacg acccgttcga 5040
cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg tcgaccaaag gtccgtctgt 5100
tttcccgctg gctccgtctt ctaaatctac ctctggtggt accgctgctc tgggttgcct 5160
ggttaaagac tacttcccgg aaccggttac cgtttcttgg aactctggtg ctctgacctc 5220
tggtgttcac accttcccgg ctgttctgca gtcttctggt ctgtactctc tgtcttctgt 5280
tgttaccgtt ccgtcttctt ctctgggtac ccagacctac atctgcaacg ttaaccacaa 5340
accgtctaac accaaagttg acaagaaagt tgaaccgaaa tcttgcctgc gatcgcggcc 5400
aggccggccg caccatcacc atcaccatgg cgcatacccg tacgacgttc cggactacgc 5460
ttctactagc taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 5520
cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 5580
cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 5640
tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 5700
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 5760
cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 5820
tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 5880
ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 5940
cgaattttaa caaaatatta acgcttacaa tttag                            5975


<210> 327
<211> 5975
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 DIQ LC** bla

<400> 327
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gatatccaga tgacccagtc tccgtctacc ctgtctgctt ctgttggtga 3180
caccatcacc atcacctgcc gtgcttctca gtctatcgaa acctggctgg cttggtacca 3240
gcagaaaccg ggtaaagctc cgaaactgct gatctacaag gcttctaccc tgaaaaccgg 3300
tgttccgtct cgtttctctg gttctggttc tggtaccgag ttcaccctga ccatctctgg 3360
tctgcagttc gacgacttcg ctacctacca ctgccagcac tacgctggtt actctgctac 3420
cttcggtcag ggtacccgtg ttgaaatcaa acgtaccgtt gctgctccgt ctgttttcat 3480
cttcccgccg tctgacgaac agctgaaatc tggtaccgct tctgttgttt gcctgctgaa 3540
caacttctac ccgcgtgaag ctaaagttca gtggaaagtt gacaacgctc tgcagtctgg 3600
taactctcag gaatctgtta ccgaacagga ctctaaagac tctacctact ctctgtcttc 3660
taccctgacc ctgtctaaag ctgactacga aaagcacaaa gtttacgctt gcgaagttac 3720
ccactaataa ctgagctctc cggttaccaa atctttcaac cgtggtgaat gcggtggtgg 3780
cagcggtggt ggttctggtg gcggtagcgg cggtggctct cacccagaaa cgctggtgaa 3840
agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 3900
cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 3960
taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 4020
tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 4080
tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 4140
cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 4200
gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 4260
cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 4320
actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 4380
ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 4440
tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 4500
tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 4560
acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aataattaat 4620
taataaggag gatataatta tgaaaaagac agctatcgcg attgcagtgg cactggctgg 4680
tttcgctacc gtagcctagg cggccgcaga agttcagctg gttgaatctg gtggtggtct 4740
ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt tctaacttcc gtatctctgc 4800
tcacaccatg aactgggttc gtcgtgttcc gggtggtggt ctggaatggg ttgcttctat 4860
ctctacctct tctacctacc gtgactacgc tgacgctgtt aaaggtcgtt tcaccgtttc 4920
tcgtgacgac ctggaagact tcgtttacct gcagatgcat aaaatgcgtg ttgaagacac 4980
cgctatctac tactgcgctc gtaaaggttc tgaccgtctg tctgacaacg acccgttcga 5040
cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg tcgaccaaag gtccgtctgt 5100
tttcccgctg gctccgtctt ctaaatctac ctctggtggt accgctgctc tgggttgcct 5160
ggttaaagac tacttcccgg aaccggttac cgtttcttgg aactctggtg ctctgacctc 5220
tggtgttcac accttcccgg ctgttctgca gtcttctggt ctgtactctc tgtcttctgt 5280
tgttaccgtt ccgtcttctt ctctgggtac ccagacctac atctgcaacg ttaaccacaa 5340
accgtctaac accaaagttg acaagaaagt tgaaccgaaa tcttgcctgc gatcgcggcc 5400
aggccggccg caccatcacc atcaccatgg cgcatacccg tacgacgttc cggactacgc 5460
ttctactagc taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 5520
cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 5580
cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 5640
tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 5700
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 5760
cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 5820
tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 5880
ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 5940
cgaattttaa caaaatatta acgcttacaa tttag                            5975


<210> 328
<211> 5978
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 HC** bla pCAL IT* CmR (DX HC** bla)

<400> 328
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccaccag ggtctgagct ctccggttac caaatctttc aaccgtggtg aatgctaatt 3780
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 3840
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 3900
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 3960
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4020
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4080
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4140
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 4200
cgacgcttgg ggtccgggta ccgttgttac cgtttaataa gcgtcgacca aaggtccgtc 4260
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 4320
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 4380
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 4440
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 4500
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 4560
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 4620
cgcttctggt ggtggcagcg gtggtggttc tggtggcggt agcggcggtg gctctcaccc 4680
agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 4740
cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 4800
aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 4860
gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 4920
agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 4980
aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 5040
gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 5100
ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 5160
aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 5220
aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 5280
tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc 5340
agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 5400
ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 5460
ttggtaagct agctaacgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 5520
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 5580
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 5640
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 5700
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 5760
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 5820
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 5880
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 5940
acgcgaattt taacaaaata ttaacgctta caatttag                         5978


<210> 329
<211> 660
<212> DNA
<213> Artificial Sequence

<220> 
<223> CmR

<400> 329
atggagaaaa aaatcactgg atataccacc gttgatatat cccaatggca tcgtaaagaa 60
cattttgagg catttcagtc agttgctcaa tgtacctata accagaccgt tcagctggat 120
attacggcct ttttaaagac cgtaaagaaa aataagcaca agttttatcc ggcctttatt 180
cacattcttg cccgcctgat gaatgctcat ccggaattcc gtatggcaat gaaagacggt 240
gagctggtga tatgggatag tgttcaccct tgttacaccg ttttccatga gcaaactgaa 300
acgttttcat cgctctggag tgaataccac gacgatttcc ggcagtttct acacatatat 360
tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt tccctaaagg gtttattgag 420
aatatgtttt tcgtctcagc caatccctgg gtgagtttca ccagttttga tttaaacgtg 480
gccaatatgg acaacttctt cgcccccgtt ttcaccatgg gcaaatatta tacgcaaggc 540
gacaaggtgc tgatgccgct ggcgattcag gttcatcatg ccgtctgtga tggcttccat 600
gtcggcagaa tgcttaatga attacaacag tactgcgatg agtggcaggg cggggcgtaa 660


<210> 330
<211> 5681
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL IT* CmR

<400> 330
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccaccag ggtctgagct ctccggttac caaatctttc aaccgtggtg aatgctaatt 3780
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 3840
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 3900
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 3960
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4020
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4080
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4140
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 4200
cgacgcttgg ggtccgggta ccgttgttac cgtttctccg gcgtcgacca aaggtccgtc 4260
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 4320
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 4380
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 4440
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 4500
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 4560
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 4620
cgcttctact agttaggagg gtggtggctc tgagggtggc ggttctgagg gtggcggctc 4680
tgagggaggc ggttccggtg gtggctctgg ttccggtgat tttgattatg aaaagatggc 4740
aaacgctaat aagggggcta tgaccgaaaa tgccgatgaa aacgcgctac agtctgacgc 4800
taaaggcaaa cttgattctg tcgctactga ttacggtgct gctatcgatg gtttcattgg 4860
tgacgtttcc ggccttgcta atggtaatgg tgctactggt gattttgctg gctctaattc 4920
ccaaatggct caagtcggtg acggtgataa ttcaccttta atgaataatt tccgtcaata 4980
tttaccttcc ctccctcaat cggttgaatg tcgccctttt gtctttggcg ctggtaaacc 5040
atatgaattt tctattgatt gtgacaaaat aaacttattc cgtggtgtct ttgcgtttct 5100
tttatatgtt gccaccttta tgtatgtatt ttctacgttt gctaacatac tgcgtaataa 5160
ggagtcttaa gctagctaac gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 5220
gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga 5280
ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg 5340
ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 5400
ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg 5460
ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 5520
gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt 5580
tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 5640
ttaacgcgaa ttttaacaaa atattaacgc ttacaattta g                     5681


<210> 331
<211> 3754
<212> DNA
<213> Artificial Sequence

<220> 
<223> pENTR 1A vector

<400> 331
ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgctagca tggatctcgg 60
ggacgtctaa ctactaagcg agagtaggga actgccaggc atcaaataaa acgaaaggct 120
cagtcggaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt 180
aggacaaatc cgccgggagc ggatttgaac gttgtgaagc aacggcccgg agggtggcgg 240
gcaggacgcc cgccataaac tgccaggcat caaactaagc agaaggccat cctgacggat 300
ggcctttttg cgtttctaca aactcttcct gttagttagt tacttaagct cgggccccaa 360
ataatgattt tattttgact gatagtgacc tgttcgttgc aacaaattga taagcaatgc 420
ttttttataa tgccaacttt gtacaaaaaa gcaggcttta aaggaaccaa ttcagtcgac 480
tggatccggt accgaattcg cggccgcatt aggcacccca ggctttacac tttatgcttc 540
cggctcgtat aatgtgtgga ttttgagtta ggatccgtcg agattttcag gagctaagga 600
agctaaaatg gagaaaaaaa tcactggata taccaccgtt gatatatccc aatggcatcg 660
taaagaacat tttgaggcat ttcagtcagt tgctcaatgt acctataacc agaccgttca 720
gctggatatt acggcctttt taaagaccgt aaagaaaaat aagcacaagt tttatccggc 780
ctttattcac attcttgccc gcctgatgaa tgctcatccg gaattccgta tggcaatgaa 840
agacggtgag ctggtgatat gggatagtgt tcacccttgt tacaccgttt tccatgagca 900
aactgaaacg ttttcatcgc tctggagtga ataccacgac gatttccggc agtttctaca 960
catatattcg caagatgtgg cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt 1020
tattgagaat atgtttttcg tctcagccaa tccctgggtg agtttcacca gttttgattt 1080
aaacgtggcc aatatggaca acttcttcgc ccccgttttc accatgggca aatattatac 1140
gcaaggcgac aaggtgctga tgccgctggc gattcaggtt catcatgccg tttgtgatgg 1200
cttccatgtc ggcagaatgc ttaatgaatt acaacagtac tgcgatgagt ggcaggcggg 1260
gcgtaatcta gaggatccgg cttactaaaa gccagataac agtatgcgta tttgcgcgct 1320
gatttttgcg gtataagaat atatactgat atgtataccc gaagtatgtc aaaaagaggt 1380
atgctatgaa gcagcgtatt acagtgacag ttgacagcga cagctatcag ttgctcaagg 1440
catatatgat gtcaatatct ccggtctggt aagcacaacc atgcagaatg aagcccgtcg 1500
tctgcgtgcc gaacgctgga aagcggaaaa tcaggaaggg atggctgagg tcgcccggtt 1560
tattgaaatg aacggctctt ttgctgacga gaacaggggc tggtgaaatg cagtttaagg 1620
tttacaccta taaaagagag agccgttatc gtctgtttgt ggatgtacag agtgatatta 1680
ttgacacgcc cgggcgacgg atggtgatcc ccctggccag tgcacgtctg ctgtcagata 1740
aagtcccccg tgaactttac ccggtggtgc atatcgggga tgaaagctgg cgcatgatga 1800
ccaccgatat ggccagtgtg ccggtctccg ttatcgggga agaagtggct gatctcagcc 1860
accgcgaaaa tgacatcaaa aacgccatta acctgatgtt ctggggaata taaatgtcag 1920
gctcccttat acacagccag tctgcaggtc gacgaattcg cggccgcact cgagatatct 1980
agacccagct ttcttgtaca aagttggcat tataagaaag cattgcttat caatttgttg 2040
caacgaacag gtcactatca gtcaaaataa aatcattatt tgccatccag ctgcagctct 2100
ggcccgtgtc tcaaaatctc tgatgttaca ttgcacaaga taaaaatata tcatcatgaa 2160
caataaaact gtctgcttac ataaacagta atacaagggg tgttatgagc catattcaac 2220
gggaaacgtc gaggccgcga ttaaattcca acatggatgc tgatttatat gggtataaat 2280
gggctcgcga taatgtcggg caatcaggtg cgacaatcta tcgcttgtat gggaagcccg 2340
atgcgccaga gttgtttctg aaacatggca aaggtagcgt tgccaatgat gttacagatg 2400
agatggtcag actaaactgg ctgacggaat ttatgcctct tccgaccatc aagcatttta 2460
tccgtactcc tgatgatgca tggttactca ccactgcgat ccccggaaaa acagcattcc 2520
aggtattaga agaatatcct gattcaggtg aaaatattgt tgatgcgctg gcagtgtccc 2580
tgcgccggtt gcattcgatt cctgtttgta attgtccttt taacagcgat cgcgtatttc 2640
gtctcgctca ggcgcaatca cgaatgaata acggtttggt tgatgcgagt gattttgatg 2700
acgagcgtaa tggctggcct gttgaacaag tctggaaaga aatgcataaa cttttgccat 2760
tctcaccgga ttcagtcgtc actcatggtg atttctcact tgataacctt atttttgacg 2820
aggggaaatt aataggttgt attgatgttg gacgagtcgg aatcgcagac cgataccagg 2880
atcttgccat cctatggaac tgcctcggtg agttttctcc ttcattacag aaacggcttt 2940
ttcaaaaata tggtattgat aatcctgata tgaataaatt gcagtttcat ttgatgctcg 3000
atgagttttt ctaatcagaa ttggttaatt ggttgtaaca ttattcagat tgggccccgt 3060
tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc 3120
tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc 3180
cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac 3240
caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac 3300
cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt 3360
cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct 3420
gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat 3480
acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt 3540
atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg 3600
cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt 3660
gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt 3720
tcctggcctt ttgctggcct tttgctcaca tgtt                             3754

<210> 332
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HexaHis Tag

<400> 332
His His His His His His
 1               5      


<210> 333
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala Fab pCAL IT* SacI

<400> 333
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgagc tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tgcggcggac gcggacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 334
<211> 5681
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab pCAL IT* Sac I CmR

<400> 334
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat ggagaaaaaa atcactggat ataccaccgt tgatatatcc caatggcatc 180
gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac cagaccgttc 240
agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag ttttatccgg 300
cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt atggcaatga 360
aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc 420
aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg cagtttctac 480
acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt 540
ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc agttttgatt 600
taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc aaatattata 660
cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg 720
gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag tggcagggcg 780
gggcgtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 840
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 900
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 960
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 1020
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 1080
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 1140
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 1200
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 1260
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 1320
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 1380
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 1440
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 1500
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 1560
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 1620
tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 1680
gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcgacacca tcgaatggcg 1740
caaaaccttt cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa 1800
tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt 1860
ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc 1920
ggcgatggcg gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca 1980
gtcgttgctg attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt 2040
cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga 2100
acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag 2160
tgggctgatc attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg 2220
cactaatgtt ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat 2280
tttctcccat gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca 2340
gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg 2400
ctggcataaa tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg 2460
gagtgccatg tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac 2520
tgcgatgctg gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc 2580
cgggctgcgc gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc 2640
atgttatatc ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag 2700
cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc 2760
cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg 2820
cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca 2880
gtgagcggta cccgataaaa gcggcttcct gacaggaggc cgttttgttt tgcagcccac 2940
ctcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 3000
cttccggctc gtatgttgtg tggaattgtg agcggataac aattgaatta aggaggatat 3060
aattatgaaa tacctgctgc cgaccgcagc cgctggtctg ctgctgctcg cggcctagcc 3120
ggccatggcc gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 3180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 3240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 3300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 3360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 3420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 3480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 3540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 3600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 3660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 3720
tacccaccag ggtctgagct ctccggttac caaatctttc aaccgtggtg aatgctaatt 3780
aattaataag gaggatataa ttatgaaaaa gacagctatc gcgattgcag tggcactggc 3840
tggtttcgct accgtagcct aggcggccgc agaagttcag ctggttgaat ctggtggtgg 3900
tctggttaaa gctggtggtt ctctgatcct gtcttgcggt gtttctaact tccgtatctc 3960
tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc 4020
tatctctacc tcttctacct accgtgacta cgctgacgct gttaaaggtc gtttcaccgt 4080
ttctcgtgac gacctggaag acttcgttta cctgcagatg cataaaatgc gtgttgaaga 4140
caccgctatc tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt 4200
cgacgcttgg ggtccgggta ccgttgttac cgtttctccg gcgtcgacca aaggtccgtc 4260
tgttttcccg ctggctccgt cttctaaatc tacctctggt ggtaccgctg ctctgggttg 4320
cctggttaaa gactacttcc cggaaccggt taccgtttct tggaactctg gtgctctgac 4380
ctctggtgtt cacaccttcc cggctgttct gcagtcttct ggtctgtact ctctgtcttc 4440
tgttgttacc gttccgtctt cttctctggg tacccagacc tacatctgca acgttaacca 4500
caaaccgtct aacaccaaag ttgacaagaa agttgaaccg aaatcttgcc tgcgatcgcg 4560
gccaggccgg ccgcaccatc accatcacca tggcgcatac ccgtacgacg ttccggacta 4620
cgcttctact agttaggagg gtggtggctc tgagggtggc ggttctgagg gtggcggctc 4680
tgagggaggc ggttccggtg gtggctctgg ttccggtgat tttgattatg aaaagatggc 4740
aaacgctaat aagggggcta tgaccgaaaa tgccgatgaa aacgcgctac agtctgacgc 4800
taaaggcaaa cttgattctg tcgctactga ttacggtgct gctatcgatg gtttcattgg 4860
tgacgtttcc ggccttgcta atggtaatgg tgctactggt gattttgctg gctctaattc 4920
ccaaatggct caagtcggtg acggtgataa ttcaccttta atgaataatt tccgtcaata 4980
tttaccttcc ctccctcaat cggttgaatg tcgccctttt gtctttggcg ctggtaaacc 5040
atatgaattt tctattgatt gtgacaaaat aaacttattc cgtggtgtct ttgcgtttct 5100
tttatatgtt gccaccttta tgtatgtatt ttctacgttt gctaacatac tgcgtaataa 5160
ggagtcttaa gctagctaac gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 5220
gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga 5280
ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg 5340
ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 5400
ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg 5460
ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 5520
gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt 5580
tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 5640
ttaacgcgaa ttttaacaaa atattaacgc ttacaattta g                     5681


<210> 335
<211> 5879
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab DIQ pCAL IT* Sac I

<400> 335
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgatatccag atgacccagt ctccgtctac 3360
cctgtctgct tctgttggtg acaccatcac catcacctgc cgtgcttctc agtctatcga 3420
aacctggctg gcttggtacc agcagaaacc gggtaaagct ccgaaactgc tgatctacaa 3480
ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct ggttctggtt ctggtaccga 3540
gttcaccctg accatctctg gtctgcagtt cgacgacttc gctacctacc actgccagca 3600
ctacgctggt tactctgcta ccttcggtca gggtacccgt gttgaaatca aacgtaccgt 3660
tgctgctccg tctgttttca tcttcccgcc gtctgacgaa cagctgaaat ctggtaccgc 3720
ttctgttgtt tgcctgctga acaacttcta cccgcgtgaa gctaaagttc agtggaaagt 3780
tgacaacgct ctgcagtctg gtaactctca ggaatctgtt accgaacagg actctaaaga 3840
ctctacctac tctctgtctt ctaccctgac cctgtctaaa gctgactacg aaaagcacaa 3900
agtttacgct tgcgaagtta cccaccaggg tctgagctct ccggttacca aatctttcaa 3960
ccgtggtgaa tgctaattaa ttaataagga ggatataatt atgaaaaaga cagctatcgc 4020
gattgcagtg gcactggctg gtttcgctac cgtagcctag gcggccgcag aagttcagct 4080
ggttgaatct ggtggtggtc tggttaaagc tggtggttct ctgatcctgt cttgcggtgt 4140
ttctaacttc cgtatctctg ctcacaccat gaactgggtt cgtcgtgttc cgggtggtgg 4200
tctggaatgg gttgcttcta tctctacctc ttctacctac cgtgactacg ctgacgctgt 4260
taaaggtcgt ttcaccgttt ctcgtgacga cctggaagac ttcgtttacc tgcagatgca 4320
taaaatgcgt gttgaagaca ccgctatcta ctactgcgct cgtaaaggtt ctgaccgtct 4380
gtctgacaac gacccgttcg acgcttgggg tccgggtacc gttgttaccg tttctccggc 4440
gtcgaccaaa ggtccgtctg ttttcccgct ggctccgtct tctaaatcta cctctggtgg 4500
taccgctgct ctgggttgcc tggttaaaga ctacttcccg gaaccggtta ccgtttcttg 4560
gaactctggt gctctgacct ctggtgttca caccttcccg gctgttctgc agtcttctgg 4620
tctgtactct ctgtcttctg ttgttaccgt tccgtcttct tctctgggta cccagaccta 4680
catctgcaac gttaaccaca aaccgtctaa caccaaagtt gacaagaaag ttgaaccgaa 4740
atcttgcctg cgatcgcggc caggccggcc gcaccatcac catcaccatg gcgcataccc 4800
gtacgacgtt ccggactacg cttctactag ttaggagggt ggtggctctg agggtggcgg 4860
ttctgagggt ggcggctctg agggaggcgg ttccggtggt ggctctggtt ccggtgattt 4920
tgattatgaa aagatggcaa acgctaataa gggggctatg accgaaaatg ccgatgaaaa 4980
cgcgctacag tctgacgcta aaggcaaact tgattctgtc gctactgatt acggtgctgc 5040
tatcgatggt ttcattggtg acgtttccgg ccttgctaat ggtaatggtg ctactggtga 5100
ttttgctggc tctaattccc aaatggctca agtcggtgac ggtgataatt cacctttaat 5160
gaataatttc cgtcaatatt taccttccct ccctcaatcg gttgaatgtc gcccttttgt 5220
ctttggcgct ggtaaaccat atgaattttc tattgattgt gacaaaataa acttattccg 5280
tggtgtcttt gcgtttcttt tatatgttgc cacctttatg tatgtatttt ctacgtttgc 5340
taacatactg cgtaataagg agtcttaagc tagctaacga tcgcccttcc caacagttgc 5400
gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 5460
tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 5520
tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 5580
tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 5640
gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 5700
agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 5760
cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 5820
agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttag  5879


<210> 336
<211> 5879
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab DVV pCAL IT* Sac I

<400> 336
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgatgttgtt atgacccagt ctccgtctac 3360
cctgtctgct tctgttggtg acaccatcac catcacctgc cgtgcttctc agtctatcga 3420
aacctggctg gcttggtacc agcagaaacc gggtaaagct ccgaaactgc tgatctacaa 3480
ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct ggttctggtt ctggtaccga 3540
gttcaccctg accatctctg gtctgcagtt cgacgacttc gctacctacc actgccagca 3600
ctacgctggt tactctgcta ccttcggtca gggtacccgt gttgaaatca aacgtaccgt 3660
tgctgctccg tctgttttca tcttcccgcc gtctgacgaa cagctgaaat ctggtaccgc 3720
ttctgttgtt tgcctgctga acaacttcta cccgcgtgaa gctaaagttc agtggaaagt 3780
tgacaacgct ctgcagtctg gtaactctca ggaatctgtt accgaacagg actctaaaga 3840
ctctacctac tctctgtctt ctaccctgac cctgtctaaa gctgactacg aaaagcacaa 3900
agtttacgct tgcgaagtta cccaccaggg tctgagctct ccggttacca aatctttcaa 3960
ccgtggtgaa tgctaattaa ttaataagga ggatataatt atgaaaaaga cagctatcgc 4020
gattgcagtg gcactggctg gtttcgctac cgtagcctag gcggccgcag aagttcagct 4080
ggttgaatct ggtggtggtc tggttaaagc tggtggttct ctgatcctgt cttgcggtgt 4140
ttctaacttc cgtatctctg ctcacaccat gaactgggtt cgtcgtgttc cgggtggtgg 4200
tctggaatgg gttgcttcta tctctacctc ttctacctac cgtgactacg ctgacgctgt 4260
taaaggtcgt ttcaccgttt ctcgtgacga cctggaagac ttcgtttacc tgcagatgca 4320
taaaatgcgt gttgaagaca ccgctatcta ctactgcgct cgtaaaggtt ctgaccgtct 4380
gtctgacaac gacccgttcg acgcttgggg tccgggtacc gttgttaccg tttctccggc 4440
gtcgaccaaa ggtccgtctg ttttcccgct ggctccgtct tctaaatcta cctctggtgg 4500
taccgctgct ctgggttgcc tggttaaaga ctacttcccg gaaccggtta ccgtttcttg 4560
gaactctggt gctctgacct ctggtgttca caccttcccg gctgttctgc agtcttctgg 4620
tctgtactct ctgtcttctg ttgttaccgt tccgtcttct tctctgggta cccagaccta 4680
catctgcaac gttaaccaca aaccgtctaa caccaaagtt gacaagaaag ttgaaccgaa 4740
atcttgcctg cgatcgcggc caggccggcc gcaccatcac catcaccatg gcgcataccc 4800
gtacgacgtt ccggactacg cttctactag ttaggagggt ggtggctctg agggtggcgg 4860
ttctgagggt ggcggctctg agggaggcgg ttccggtggt ggctctggtt ccggtgattt 4920
tgattatgaa aagatggcaa acgctaataa gggggctatg accgaaaatg ccgatgaaaa 4980
cgcgctacag tctgacgcta aaggcaaact tgattctgtc gctactgatt acggtgctgc 5040
tatcgatggt ttcattggtg acgtttccgg ccttgctaat ggtaatggtg ctactggtga 5100
ttttgctggc tctaattccc aaatggctca agtcggtgac ggtgataatt cacctttaat 5160
gaataatttc cgtcaatatt taccttccct ccctcaatcg gttgaatgtc gcccttttgt 5220
ctttggcgct ggtaaaccat atgaattttc tattgattgt gacaaaataa acttattccg 5280
tggtgtcttt gcgtttcttt tatatgttgc cacctttatg tatgtatttt ctacgtttgc 5340
taacatactg cgtaataagg agtcttaagc tagctaacga tcgcccttcc caacagttgc 5400
gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 5460
tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 5520
tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 5580
tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 5640
gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 5700
agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 5760
cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 5820
agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttag  5879


<210> 337
<211> 5879
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala Fab DIQ pCAL IT* Sac I

<400> 337
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgatatccag atgacccagt ctccgtctac 3360
cctgtctgct tctgttggtg acaccatcac catcacctgc cgtgcttctc agtctatcga 3420
aacctggctg gcttggtacc agcagaaacc gggtaaagct ccgaaactgc tgatctacaa 3480
ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct ggttctggtt ctggtaccga 3540
gttcaccctg accatctctg gtctgcagtt cgacgacttc gctacctacc actgccagca 3600
ctacgctggt tactctgcta ccttcggtca gggtacccgt gttgaaatca aacgtaccgt 3660
tgctgctccg tctgttttca tcttcccgcc gtctgacgaa cagctgaaat ctggtaccgc 3720
ttctgttgtt tgcctgctga acaacttcta cccgcgtgaa gctaaagttc agtggaaagt 3780
tgacaacgct ctgcagtctg gtaactctca ggaatctgtt accgaacagg actctaaaga 3840
ctctacctac tctctgtctt ctaccctgac cctgtctaaa gctgactacg aaaagcacaa 3900
agtttacgct tgcgaagtta cccaccaggg tctgagctct ccggttacca aatctttcaa 3960
ccgtggtgaa tgctaattaa ttaataagga ggatataatt atgaaaaaga cagctatcgc 4020
gattgcagtg gcactggctg gtttcgctac cgtagcctag gcggccgcag aagttcagct 4080
ggttgaatct ggtggtggtc tggttaaagc tggtggttct ctgatcctgt cttgcggtgt 4140
ttctaacttc cgtatctctg ctcacaccat gaactgggtt cgtcgtgttc cgggtggtgg 4200
tctggaatgg gttgcttcta tctctacctc ttctacctac cgtgactacg ctgacgctgt 4260
taaaggtcgt ttcaccgttt ctcgtgacga cctggaagac ttcgtttacc tgcagatgca 4320
taaaatgcgt gttgaagaca ccgctatcta ctactgcgct cgtaaaggtt ctgaccgtgc 4380
ggcggacgcg gacccgttcg acgcttgggg tccgggtacc gttgttaccg tttctccggc 4440
gtcgaccaaa ggtccgtctg ttttcccgct ggctccgtct tctaaatcta cctctggtgg 4500
taccgctgct ctgggttgcc tggttaaaga ctacttcccg gaaccggtta ccgtttcttg 4560
gaactctggt gctctgacct ctggtgttca caccttcccg gctgttctgc agtcttctgg 4620
tctgtactct ctgtcttctg ttgttaccgt tccgtcttct tctctgggta cccagaccta 4680
catctgcaac gttaaccaca aaccgtctaa caccaaagtt gacaagaaag ttgaaccgaa 4740
atcttgcctg cgatcgcggc caggccggcc gcaccatcac catcaccatg gcgcataccc 4800
gtacgacgtt ccggactacg cttctactag ttaggagggt ggtggctctg agggtggcgg 4860
ttctgagggt ggcggctctg agggaggcgg ttccggtggt ggctctggtt ccggtgattt 4920
tgattatgaa aagatggcaa acgctaataa gggggctatg accgaaaatg ccgatgaaaa 4980
cgcgctacag tctgacgcta aaggcaaact tgattctgtc gctactgatt acggtgctgc 5040
tatcgatggt ttcattggtg acgtttccgg ccttgctaat ggtaatggtg ctactggtga 5100
ttttgctggc tctaattccc aaatggctca agtcggtgac ggtgataatt cacctttaat 5160
gaataatttc cgtcaatatt taccttccct ccctcaatcg gttgaatgtc gcccttttgt 5220
ctttggcgct ggtaaaccat atgaattttc tattgattgt gacaaaataa acttattccg 5280
tggtgtcttt gcgtttcttt tatatgttgc cacctttatg tatgtatttt ctacgtttgc 5340
taacatactg cgtaataagg agtcttaagc tagctaacga tcgcccttcc caacagttgc 5400
gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 5460
tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 5520
tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 5580
tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 5640
gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 5700
agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 5760
cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 5820
agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttag  5879


<210> 338
<211> 5879
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala Fab DVV pCAL IT* SacI

<400> 338
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgatgttgtt atgacccagt ctccgtctac 3360
cctgtctgct tctgttggtg acaccatcac catcacctgc cgtgcttctc agtctatcga 3420
aacctggctg gcttggtacc agcagaaacc gggtaaagct ccgaaactgc tgatctacaa 3480
ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct ggttctggtt ctggtaccga 3540
gttcaccctg accatctctg gtctgcagtt cgacgacttc gctacctacc actgccagca 3600
ctacgctggt tactctgcta ccttcggtca gggtacccgt gttgaaatca aacgtaccgt 3660
tgctgctccg tctgttttca tcttcccgcc gtctgacgaa cagctgaaat ctggtaccgc 3720
ttctgttgtt tgcctgctga acaacttcta cccgcgtgaa gctaaagttc agtggaaagt 3780
tgacaacgct ctgcagtctg gtaactctca ggaatctgtt accgaacagg actctaaaga 3840
ctctacctac tctctgtctt ctaccctgac cctgtctaaa gctgactacg aaaagcacaa 3900
agtttacgct tgcgaagtta cccaccaggg tctgagctct ccggttacca aatctttcaa 3960
ccgtggtgaa tgctaattaa ttaataagga ggatataatt atgaaaaaga cagctatcgc 4020
gattgcagtg gcactggctg gtttcgctac cgtagcctag gcggccgcag aagttcagct 4080
ggttgaatct ggtggtggtc tggttaaagc tggtggttct ctgatcctgt cttgcggtgt 4140
ttctaacttc cgtatctctg ctcacaccat gaactgggtt cgtcgtgttc cgggtggtgg 4200
tctggaatgg gttgcttcta tctctacctc ttctacctac cgtgactacg ctgacgctgt 4260
taaaggtcgt ttcaccgttt ctcgtgacga cctggaagac ttcgtttacc tgcagatgca 4320
taaaatgcgt gttgaagaca ccgctatcta ctactgcgct cgtaaaggtt ctgaccgtgc 4380
ggcggacgcg gacccgttcg acgcttgggg tccgggtacc gttgttaccg tttctccggc 4440
gtcgaccaaa ggtccgtctg ttttcccgct ggctccgtct tctaaatcta cctctggtgg 4500
taccgctgct ctgggttgcc tggttaaaga ctacttcccg gaaccggtta ccgtttcttg 4560
gaactctggt gctctgacct ctggtgttca caccttcccg gctgttctgc agtcttctgg 4620
tctgtactct ctgtcttctg ttgttaccgt tccgtcttct tctctgggta cccagaccta 4680
catctgcaac gttaaccaca aaccgtctaa caccaaagtt gacaagaaag ttgaaccgaa 4740
atcttgcctg cgatcgcggc caggccggcc gcaccatcac catcaccatg gcgcataccc 4800
gtacgacgtt ccggactacg cttctactag ttaggagggt ggtggctctg agggtggcgg 4860
ttctgagggt ggcggctctg agggaggcgg ttccggtggt ggctctggtt ccggtgattt 4920
tgattatgaa aagatggcaa acgctaataa gggggctatg accgaaaatg ccgatgaaaa 4980
cgcgctacag tctgacgcta aaggcaaact tgattctgtc gctactgatt acggtgctgc 5040
tatcgatggt ttcattggtg acgtttccgg ccttgctaat ggtaatggtg ctactggtga 5100
ttttgctggc tctaattccc aaatggctca agtcggtgac ggtgataatt cacctttaat 5160
gaataatttc cgtcaatatt taccttccct ccctcaatcg gttgaatgtc gcccttttgt 5220
ctttggcgct ggtaaaccat atgaattttc tattgattgt gacaaaataa acttattccg 5280
tggtgtcttt gcgtttcttt tatatgttgc cacctttatg tatgtatttt ctacgtttgc 5340
taacatactg cgtaataagg agtcttaagc tagctaacga tcgcccttcc caacagttgc 5400
gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 5460
tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 5520
tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 5580
tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 5640
gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 5700
agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 5760
cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 5820
agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttag  5879


<210> 339
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> YASA-R

<400> 339
gtgctggcag tggtaggtag cgaag                                       25

<210> 340
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> QHYA-R

<400> 340
gcagtggtag gtagcgaagt cgtc                                        24

<210> 341
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR3

<400> 341
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 342
<211> 68
<212> DNA
<213> Artificial Sequence

<220> 
<223> LCDR3-YASA 5'

<220> 
<221> variation      
<222> 26, 27, 29, 30, 38, 39, 41, 42
<223> n = a, c, g or t

<400> 342
cttcgctacc taccactgcc agcacnnknn kggttacnnk nnkaccttcg gtcagggtac 60
ccgtgttg                                                          68

<210> 343
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> LCDR3-QHYA 5

<220> 
<221> variation      
<222> 25, 26, 28, 29, 31, 32, 34, 35
<223> n = a, c, g or t

<400> 343
gacgacttcg ctacctacca ctgcnnknnk nnknnkggtt actctgctac cttcggtcag 60
ggtacccgtg                                                        70

<210> 344
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> KGDD-R

<400> 344
acgagcgcag tagtagatag cggtg                                       25

<210> 345
<211> 81
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCDR3-KGDD 5'

<220> 
<221> variation      
<222> 26, 27, 29, 30, 47, 48, 53, 54
<223> n = a, c, g or t

<400> 345
caccgctatc tactactgcg ctcgtnnknn ktctgaccgt ctgtctnnka acnnkccgtt 60
cgacgcttgg ggtccgggta c                                           81

<210> 346
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HCmutR2

<400> 346
ggcgctgtcg gtaggctctt ccgtcgacgc cggagaaacg gt                    42

<210> 347
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HCmutF1

<400> 347
ggcgctgtcg gtaggctctt ccgcggccgc agaagttcag ctg                   43

<210> 348
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX22

<400> 348
ggcgctgtcg gtaggctctt cc                                          22

<210> 349
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> F1

<400> 349
gccgctgtgc catcgctcag taacgcggcc gcagaagttc agctg                 45

<210> 350
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> R1

<400> 350
ggcggcgctc ttcagttaga aacaccgcaa gacaggatc                        39

<210> 351
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> F2

<400> 351
ggcggcgctc ttctcgtgtt ccgggtggtg gtctg                            35

<210> 352
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> R3

<400> 352
gccgctgtgc catcgctcag taacgtcgac gccggagaaa cggt                  44

<210> 353
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1F

<220> 
<221> variation      
<222> 19, 20, 22, 23
<223> n = a, c, g or t

<400> 353
aacttccgta tctctgctnn tnnkatgaac tgggttcgt                        39

<210> 354
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1R

<220> 
<221> variation      
<222> 20, 21, 23, 24
<223> n = a, c, g or t

<400> 354
acgacgaacc cagttcatmn nannagcaga gatacggaa                        39

<210> 355
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> R2

<400> 355
ggcggcgctc ttcagtagat agcggtgtct tcaacac                          37

<210> 356
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F3

<400> 356
ggcggcgctc ttcgggtccg ggtaccgttg ttac                             34

<210> 357
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3F

<220> 
<221> variation      
<222> 19, 20, 31, 32, 34, 35, 40, 41, 43, 44
<223> n = a, c, g or t

<400> 357
tactactgcg ctcgtaaann ktctgaccgt nntnnkgacn nknnkccgtt cgacgcttgg 60


<210> 358
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3R

<220> 
<221> variation      
<222> 20, 21, 23, 24, 29, 30, 32, 33, 44, 45
<223> n = a, c, g or t

<400> 358
accccaagcg tcgaacggmn nmnngtcmnn annacggtca gamnntttac gagcgcagta 60


<210> 359
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HCmutR1

<400> 359
tttacgagcg cagtagtaga tag                                         23

<210> 360
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HCmutF2

<220> 
<221> variation      
<222> 26, 27, 38, 39, 41, 42, 47, 48, 50, 51
<223> n = a, c, g or t

<400> 360
cgctatctac tactgcgctc gtaaannktc tgaccgtnnt nnkgacnnkn nkccgttcga 60
cgcttggggt c                                                      71

<210> 361
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALMfeI-F

<400> 361
gttagctcac tcattaggca c                                           21

<210> 362
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> Not I restriction site

<400> 362
gcggccgc                                                          8

<210> 363
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sal I restriction site

<400> 363
gtcgac                                                            6

<210> 364
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12NLCF2

<220> 
<221> variation      
<222> 22, 23, 25, 26, 31, 32, 34, 35, 37, 38
<223> n = a, c, g or t

<400> 364
gctacctacc actgccagca cnnknnkggt nnknnknnka ccttcggtca gggt       54

<210> 365
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12NLCR2

<220> 
<221> variation      
<222> 20, 21, 23, 24, 26, 27, 32, 33, 35, 36
<223> n = a, c, g or t

<400> 365
ggtaccctga ccgaaggtmn nmnnmnnacc mnnmnngtgc tggcagtggt aggt       54

<210> 366
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF3

<400> 366
ggcggcgctc ttctacccgt gttgaaatca aacgt                            35

<210> 367
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR3

<400> 367
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 368
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> SapIAla-R

<400> 368
cgaaggtcgc ggccgcaccc gcggcgtgct ggcaggctct tctagcgaag tcgtcgaact 60
gcagac                                                            66

<210> 369
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> SapIAla-F

<400> 369
ctgccagcac gccgcgggtg cggccgcgac cttcggctct tctacccgtg ttgaaatcaa 60
acgtac                                                            66

<210> 370
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCmutR1

<220> 
<221> variation      
<222> 24, 25, 27, 28, 30, 31, 36, 37, 39, 40
<223> n = a, c, g or t

<400> 370
cacgggtacc ctgaccgaag gtmnnmnnmn naccmnnmnn atgctggcag tggtaggtag 60


<210> 371
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCmutF1

<400> 371
accttcggtc agggtacc                                               18

<210> 372
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala LC

<400> 372
Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala Ala Thr Phe Gly
 1               5                  10                  15      
Gln Gly Thr
            


<210> 373
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3Ala LC SapI

<400> 373
Ala Arg Gly Ala Cys Gln His Ala Ala Gly Ala Ala Ala Thr Phe Gly
 1               5                  10                  15      
Ser Ser Thr
            


<210> 374
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward Primer

<400> 374
gctagaagag cctgccagca cgccgcgggt gcggccgcga ccttcggctc ttctacc    57

<210> 375
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse Primer

<400> 375
cgatcttctc ggacggtcgt gcggcgccca cgccggcgct ggaagccgag aagatgg    57

<210> 376
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALLC-F

<400> 376
ggatataatt atgaaatacc                                             20

<210> 377
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALMfeI-F

<400> 377
gttagctcac tcattaggca c                                           21

<210> 378
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXLCF1

<400> 378
gccgctgtgc catcgctcag taacggataa caattgaatt aaggagg               47

<210> 379
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXL3-R

<400> 379
gcagtggtag gtcgcgaagt cgtcgaactg c                                31

<210> 380
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXL3-F

<220> 
<221> variation      
<222> 38, 41, 42, 48
<223> n = a, c, g or t

<400> 380
cgacgacttc gcgacctacc actgckvybv bbvbdvynvh nnbbvbbnba ccttcggtca 60
gggtacccgt g                                                      71

<210> 381
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXLCR2

<400> 381
gccgctgtgc catcgctcag taacgagctc agaccctggt gggtaac               47

<210> 382
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXH1-R

<400> 382
gctgatacgg aagttgctaa caccgcaaga cagg                             34

<210> 383
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXH1-F

<400> 383
cttgcggtgt tagcaacttc cgtatcagcd myymydvyat gwmytgggtt cgtcgtgttc 60
cgg                                                               63

<210> 384
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXH3-R

<400> 384
acgcgcgcag tagtagatag cggtgtc                                     27

<210> 385
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXH3-F

<220> 
<221> variation      
<222> 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 44, 47, 49, 50, 52,
53, 56, 59
<223> n = a, g, c or t

<400> 385
gacaccgcta tctactactg cgcgcgtdnh nnbnnbnnbn nynnbdnynn bnnbdnbbnb 60
ttcgacgctt ggggtccg                                               78

<210> 386
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXH3ext-F

<400> 386
gacaccgcta tctactactg cgcg                                        24

<210> 387
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nsi-R

<400> 387
gccgctgtgc catcgctcag taacatgcat ctgcaggtaa acgaagtc              48

<210> 388
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nsi-F

<400> 388
gccgctgtgc catcgctcag taacatgcat aaaatgcgtg ttgaagac              48

<210> 389
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3(-)(H3all)

<400> 389
ccgggcccca agcgtcgaac                                             20

<210> 390
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3(+)(L3+H3)

<400> 390
ctgcgcgcgt aaakrttmtk mthrtyhttm tkmtwmtkmt ccgttcgacg cttggggccc 60
gg                                                                62

<210> 391
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3(+)(H1+H3)

<400> 391
ctgcgcgcgt rrgkrttmtk mthrtyhttm tkmtwmtkmt ccgttcgacg cttggggccc 60
gg                                                                62

<210> 392
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3(+)(L3+H1+H3)

<400> 392
ctgcgcgcgt aaaggttmtk mthrtyhttc tkmtwmtkmt ccgttcgacg cttggggccc 60
gg                                                                62

<210> 393
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3(-)(L3all)

<400> 393
caacgcgtgt accctgaccg                                             20

<210> 394
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3(-)(H3all)

<400> 394
ccgggcccca agcgtcgaac                                             20

<210> 395
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1(-)(H1all)

<400> 395
cccggaacgc gtctaacc                                               18

<210> 396
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF

<400> 396
gccgctgtgc catcgctcag taacaattga attaaggagg a                     41

<210> 397
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> DXmiL3-R

<400> 397
ctggcagtgg tacgtagcga agtcgtc                                     27

<210> 398
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR

<400> 398
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 399
<211> 64
<212> DNA
<213> Artificial Sequence

<220> 
<223> CDRL3 DX Minimalist Library

<400> 399
gctacgtacc actgccagca stmckmcrrc tmcymcgcta ccttcggtca gggtacacgc 60
gttg                                                              64

<210> 400
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> CDRH1 DX Minimalist Library

<400> 400
ctttcgaatc tctkctyacw mcatgwmctg ggttagacgc gttccggg              48

<210> 401
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> CDRH3 DX Minimalist Library

<400> 401
ctgcgcgcgt rrsvgctmtk mcvgcyhctm tkmcwmckmc ccgttcgacg cttggggccc 60
gg                                                                62

<210> 402
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3 snaB1 forward

<400> 402
gttcgacgac ttcgctacgt accactgcca gcactacg                         38

<210> 403
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3 snaB1 reverse

<400> 403
cgtagtgctg gcagtggtac gtagcgaagt cgtcgaac                         38

<210> 404
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3 mluI forward

<400> 404
cttcggtcag ggtacacgcg ttgaaatcaa acgtac                           36

<210> 405
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3 mluI reverse

<400> 405
gtacgtttga tttcaacgcg tgtaccctga ccgaag                           36

<210> 406
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1 bstbi forward

<400> 406
gcggtgtttc taactttcga atctctgctc acacc                            35

<210> 407
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1 bstbi reverse

<400> 407
ggtgtgagca gagattcgaa agttagaaac accgc                            35

<210> 408
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1 mluI forward

<400> 408
ccatgaactg ggttagacgc gttccgggtg gtggtctgg                        39

<210> 409
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1 mluI reverse

<400> 409
ccagaccacc acccggaacg cgtctaaccc agttcatgg                        39

<210> 410
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3 BssHII forward

<400> 410
ccgctatcta ctactgcgcg cgtaaaggtt ctgaccg                          37

<210> 411
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3 BssHII reverse

<400> 411
cggtcagaac ctttacgcgc gcagtagtag atagcgg                          37

<210> 412
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3 apaI forward

<400> 412
cccgttcgac gcttggggcc cgggtaccgt tgttaccg                         38

<210> 413
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3 apaI reverse

<400> 413
cggtaacaac ggtacccggg ccccaagcgt cgaacggg                         38

<210> 414
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3 vector

<400> 414
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgtgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggtccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgtgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacgt accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtaca cgcgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 415
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1 vector

<400> 415
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgtgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggtccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgtgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac tttcgaatct ctgctcacac catgaactgg gttagacgcg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 416
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3 vector

<400> 416
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgtgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggtccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgtgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gcgcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggcccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 417
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1H3 vector

<400> 417
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgtgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggtccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgtgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac tttcgaatct ctgctcacac catgaactgg gttagacgcg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gcgcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggcccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 418
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3H3 vector

<400> 418
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgtgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggtccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgtgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacgt accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtaca cgcgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gcgcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggcccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 419
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> Clone7

<400> 419
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac tttcgaatct cttcccactc catgtactgg gttagacgcg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gcgcgtggga gctacgacgg 4380
ctactacgcc aactacccgt tcgacgcttg gggcccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 420
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A

<400> 420
gcccaggcgg ccgcagaagt tcag                                        24

<210> 421
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> B

<220> 
<221> variation      
<222> 24, 25, 27, 28
<223> n = a, c, g or t

<400> 421
gaacacgacg aacccagttc atmnnannag cagagatacg gaagttag              48

<210> 422
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> C

<220> 
<221> variation      
<222> 21, 22, 24, 25
<223> n = a, c, g or t

<400> 422
ctaacttccg tatctctgct nntnnkatga actgggttcg tcgtgttc              48

<210> 423
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> D

<220> 
<221> variation      
<222> 24, 25, 27, 28, 33, 34, 36, 37, 48, 49
<223> n = a, c, g or t

<400> 423
ccggacccca agcgtcgaac ggmnnmnngt cmnnannacg gtcagamnnt ttacgagcgc 60
agtagtagat ag                                                     72

<210> 424
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> E

<400> 424
cctttggtcg acgccggaga aacggtaaca acggtacccg gaccccaagc gtcgaacg   58

<210> 425
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24H1S-F

<400> 425
gccgctgtgc catcgctcag taacgcggcc gcagaagttc agctg                 45

<210> 426
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1S-R

<400> 426
agacaggatc agagaaccac cag                                         23

<210> 427
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1L-F

<400> 427
gcggccgcag aagttcagct g                                           21

<210> 428
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1L-R

<400> 428
agcagagata cggaagttag aaac                                        24

<210> 429
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> H2-F

<400> 429
tgcggtgttt ctaacttccg tatctctgct                                  30

<210> 430
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> H2-R

<400> 430
accacccgga acacgacgaa cccagttcat                                  30

<210> 431
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3L-F

<400> 431
atgaactggg ttcgtcgtgt tccg                                        24

<210> 432
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3L-R

<400> 432
tttacgagcg cagtagtaga tagc                                        24

<210> 433
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3S-F

<400> 433
ggtctggaat gggttgcttc tatc                                        24

<210> 434
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3S-R

<400> 434
ttcaacacgc attttatgca tctg                                        24

<210> 435
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4-F

<400> 435
gacaccgcta tctactactg cgctcgtaaa                                  30

<210> 436
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4-R

<400> 436
aacggtaccc ggaccccaag cgtcgaacgg                                  30

<210> 437
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> H5-F

<400> 437
ccgttcgacg cttggggtcc g                                           21

<210> 438
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24H5-F

<400> 438
gttaccgttt ctccggcgtc gacgttactg agcgatggca cagcggc               47

<210> 439
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24H5-R

<400> 439
gccgctgtgc catcgctcag taacgtcgac gccggagaaa cggtaac               47

<210> 440
<211> 76
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1

<400> 440
ggccgcagaa gttcagctgg ttgaatctgg tggtggtctg gttaaagctg gtggttctct 60
gatcctgtct tgcggt                                                 76

<210> 441
<211> 84
<212> DNA
<213> Artificial Sequence

<220> 
<223> H2

<400> 441
gaagttagaa acaccgcaag acaggatcag agaaccacca gctttaacca gaccaccacc 60
agattcaacc agctgaactt ctgc                                        84

<210> 442
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3

<220> 
<221> variation      
<222> 25, 26, 28, 29
<223> n = a, c, g or t

<400> 442
gtttctaact tccgtatctc tgctnntnnk atgaactggg                       40

<210> 443
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4

<220> 
<221> variation      
<222> 24, 25, 27, 28
<223> n = a, c, g or t

<400> 443
gaacacgacg aacccagttc atmnnannag cagagatacg                       40

<210> 444
<211> 82
<212> DNA
<213> Artificial Sequence

<220> 
<223> H5

<400> 444
ttcgtcgtgt tccgggtggt ggtctggaat gggttgcttc tatctctacc tcttctacct 60
accgtgacta cgctgacgct gt                                          82

<210> 445
<211> 82
<212> DNA
<213> Artificial Sequence

<220> 
<223> H6

<400> 445
aaacgacctt taacagcgtc agcgtagtca cggtaggtag aagaggtaga gatagaagca 60
acccattcca gaccaccacc cg                                          82

<210> 446
<211> 82
<212> DNA
<213> Artificial Sequence

<220> 
<223> H7

<400> 446
taaaggtcgt ttcaccgttt ctcgtgacga cctggaagac ttcgtttacc tgcagatgca 60
taaaatgcgt gttgaagaca cc                                          82

<210> 447
<211> 82
<212> DNA
<213> Artificial Sequence

<220> 
<223> H8

<400> 447
gtagtagata gcggtgtctt caacacgcat tttatgcatc tgcaggtaaa cgaagtcttc 60
caggtcgtca cgagaaacgg tg                                          82

<210> 448
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> H9

<220> 
<221> variation      
<222> 25, 26, 37, 38, 40, 41, 46, 47, 49, 50
<223> n = a, c, g or t

<400> 448
gctatctact actgcgctcg taaannktct gaccgtnntn nkgacnnknn kccgttcgac 60
gcttggggt                                                         69

<210> 449
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> H10

<220> 
<221> variation      
<222> 32, 33, 35, 36, 41, 42, 44, 45, 56, 57
<223> n = a, c, g or t

<400> 449
aacggtaccc ggaccccaag cgtcgaacgg mnnmnngtcm nnannacggt cagamnnttt 60
acgagcgca                                                         69

<210> 450
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> H11

<400> 450
ccgggtaccg ttgttaccgt ttctccggcg                                  30

<210> 451
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> H12

<400> 451
tcgacgccgg agaaacggta ac                                          22

<210> 452
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> OHGLSPA-F

<400> 452
ggctggtttc gctaccgtag cccag                                       25

<210> 453
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> H0

<400> 453
cagaccacca ccagattcaa ccagctgaac ttctgcggcc gcgttactga gcgatggcac 60
agcggc                                                            66

<210> 454
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> H2b

<400> 454
gaagttagaa acaccgcaag acaggatcag agaaccacca gctttaac              48

<210> 455
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> H10b

<220> 
<221> variation      
<222> 24-25, 27-28, 33-34, 36-37, 48-49
<223> n = a or c or t or g

<400> 455
ccggacccca agcgtcgaac ggmnnmnngt cmnnannacg gtcagamnnt ttacgagcgc 60
a                                                                 61

<210> 456
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> H12b

<400> 456
gccgctgtgc catcgctcag taacgtcgac gccggagaaa cggtaacaac ggtac      55

<210> 457
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant (4F8)

<400> 457
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 458
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 458
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 459
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 459
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 460
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 460
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ala Trp Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 461
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 461
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 462
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 462
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 463
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 463
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ser Trp Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 464
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 464
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 465
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 465
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 466
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 466
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 467
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 467
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 468
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 468
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 469
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 469
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 470
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 470
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Glu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 471
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 471
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Glu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 472
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 472
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 473
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 473
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 474
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 474
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 475
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 475
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 476
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 476
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ser Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 477
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 477
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 478
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 478
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 479
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 479
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 480
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 480
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr His Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 481
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 481
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 482
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 482
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 483
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 483
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 484
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 484
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 485
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 485
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 486
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 486
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 487
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 487
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 488
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 488
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 489
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 489
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 490
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 490
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 491
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 491
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 492
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 492
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 493
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 493
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 494
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 494
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Thr Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 495
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 495
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Pro Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 496
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 496
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 497
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 497
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Pro Phe Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 498
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 498
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 499
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 499
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 500
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 500
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 501
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 501
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 502
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 502
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 503
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 503
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 504
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 504
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 505
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 505
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 506
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 506
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Val Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 507
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 507
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 508
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 508
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Gln Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 509
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 509
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro His Thr Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 510
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 510
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Asp Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 511
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 511
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Arg Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 512
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 512
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Ala His Thr Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 513
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 513
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Thr Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 514
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 514
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His His Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 515
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 515
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Lys Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 516
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 516
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Arg Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 517
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 517
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Tyr Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 518
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 518
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 519
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 519
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 520
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 520
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 521
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 521
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Trp Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 522
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 522
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asn Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 523
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 523
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Glu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 524
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 524
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 525
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 525
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 526
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 526
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 527
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 527
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 528
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 528
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 529
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 529
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 530
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 530
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 531
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 531
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Val Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 532
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 532
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Trp Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 533
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 533
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Trp Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 534
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 534
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 535
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 535
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 536
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 536
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Val Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 537
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 537
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 538
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 538
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 539
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 539
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 540
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 540
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Asn Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 541
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 541
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Pro Tyr Trp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 542
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 542
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Glu Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 543
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 543
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Leu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 544
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 544
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Gly Ala
                85                  90                  95      
Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 545
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 545
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Asp Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 546
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 546
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Ala Tyr Gln Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 547
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 547
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Ala Phe Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 548
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 548
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Asn Pro Leu Ser Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 549
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 549
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 550
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 550
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Arg Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 551
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab pCAL IT* Sac I

<400> 551
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgagc tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 552
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 SapI 3Ala LC pCAL IT* vector

<400> 552
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctagaa gagcctgcca 3600
gcacgccgcg ggtgcggccg cgaccttcgg ctcttctacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 553
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> DIQ 2G12 Light Chain

<400> 553
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 554
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 554
Gln His Tyr Asp Gly Arg Ala Ser Thr
 1               5                  


<210> 555
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 555
Gln His Tyr Asn Gly Arg Thr Thr Thr
 1               5                  


<210> 556
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 556
Gln His Tyr Asp Gly Arg Ala Ser Thr
 1               5                  


<210> 557
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 557
Gln His Tyr Ser Gly Tyr Glu Ala Thr
 1               5                  


<210> 558
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 558
Gln His Tyr Ala Gly Tyr Asp Ala Thr
 1               5                  


<210> 559
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 559
Gln His Tyr Ala Gly Tyr His Ala Thr
 1               5                  


<210> 560
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 560
Gln His Tyr Asp Gly Arg Ile Ala Thr
 1               5                  


<210> 561
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 561
Gln His Tyr Glu Gly Arg Asp Ala Thr
 1               5                  


<210> 562
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 562
Gln His Tyr Asp Gly Arg His Ser Thr
 1               5                  


<210> 563
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 563
Gln His His Thr Gly Arg Ser Ala Thr
 1               5                  


<210> 564
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 564
Gln His Tyr Thr Gly Asn Glu Ala Thr
 1               5                  


<210> 565
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 565
Gln His Tyr Thr Gly Phe Ala Ala Thr
 1               5                  


<210> 566
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 566
Gln His Tyr Asp Gly Arg His Ala Thr
 1               5                  


<210> 567
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 567
Gln His Tyr Thr Gly Ser His Ser Thr
 1               5                  


<210> 568
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 568
Gln His Tyr Thr Gly Val Ala Ser Thr
 1               5                  


<210> 569
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 569
Gln His Tyr Glu Gly Gln Lys Ser Thr
 1               5                  


<210> 570
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 570
Gln His Tyr Asn Gly Tyr Arg Ser Thr
 1               5                  


<210> 571
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 571
Gln His Tyr Thr Gly Arg Glu Thr Thr
 1               5                  


<210> 572
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 572
Gln His Tyr Ser Gly Arg Leu Ala Thr
 1               5                  


<210> 573
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 573
Gln His Tyr Ser Gly Leu Lys Ser Thr
 1               5                  


<210> 574
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 574
Gln His Tyr His Gly Arg Val Ala Thr
 1               5                  


<210> 575
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 575
Gln His Tyr Asn Gly Ala Thr Ser Thr
 1               5                  


<210> 576
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 576
Gln His Tyr Thr Gly Thr Arg Ser Thr
 1               5                  


<210> 577
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 577
Gln His Tyr Ser Gly Thr Ser Ser Thr
 1               5                  


<210> 578
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 578
Gln His Tyr Thr Gly Ser Ala Ser Thr
 1               5                  


<210> 579
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 579
Gln His Tyr Asp Gly Met Thr Ser Thr
 1               5                  


<210> 580
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 580
Gln His Tyr Thr Gly Met Arg Thr Thr
 1               5                  


<210> 581
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 581
Gln His Tyr Glu Gly Arg Thr Ser Thr
 1               5                  


<210> 582
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 582
Gln His Tyr Thr Gly Arg Glu Ser Thr
 1               5                  


<210> 583
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 583
Gln His Tyr Leu Gly Arg Ser Ser Thr
 1               5                  


<210> 584
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 584
Gln His Tyr Thr Gly Glu Ser Cys Thr
 1               5                  


<210> 585
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 585
Gln His Tyr Ser Gly Arg Ser Ser Thr
 1               5                  


<210> 586
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 586
Gln His Tyr Thr Gly Arg Ala Ser Thr
 1               5                  


<210> 587
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 587
Gln His Tyr Glu Gly Arg Gly Ala Thr
 1               5                  


<210> 588
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 588
Gln His Tyr Ser Gly Arg Ser Ala Thr
 1               5                  


<210> 589
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 589
Gln His Tyr Thr Gly Met Phe Ala Thr
 1               5                  


<210> 590
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 590
Gln His Tyr Ser Gly Val Asn Ser Thr
 1               5                  


<210> 591
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 591
Gln His Tyr Leu Gly Gln Arg Thr Thr
 1               5                  


<210> 592
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 592
Gln His Tyr Thr Gly Met Leu Asn Thr
 1               5                  


<210> 593
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 593
Gln His Tyr Asp Gly Asn Glu Ser Thr
 1               5                  


<210> 594
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 594
Gln His Arg Glu Gly Val Tyr Ser Thr
 1               5                  


<210> 595
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 595
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ala
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 596
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 596
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Arg Thr
                85                  90                  95      
Thr Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 597
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 597
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ala
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 598
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 598
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Tyr Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 599
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 599
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 600
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 600
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 601
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 601
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ile
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 602
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 602
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 603
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 603
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg His
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 604
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 604
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His His Thr Gly Arg Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 605
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 605
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Asn Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 606
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 606
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 607
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 607
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 608
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 608
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Ser His
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 609
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 609
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Val Ala
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 610
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 610
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Gln Lys
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 611
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 611
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Tyr Arg
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 612
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 612
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Glu
                85                  90                  95      
Thr Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 613
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 613
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Leu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 614
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 614
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Leu Lys
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 615
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 615
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr His Gly Arg Val
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 616
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 616
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Ala Thr
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 617
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 617
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Thr Arg
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 618
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 618
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Thr Ser
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 619
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 619
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Ser Ala
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 620
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 620
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Met Thr
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 621
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 621
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Arg
                85                  90                  95      
Thr Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 622
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 622
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Thr
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 623
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 623
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Glu
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 624
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 624
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Gly Arg Ser
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 625
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 625
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Glu Ser
                85                  90                  95      
Cys Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 626
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 626
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Ser
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 627
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 627
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Ala
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 628
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 628
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 629
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 629
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 630
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 630
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Phe
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 631
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 631
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Val Asn
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 632
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 632
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Gly Gln Arg
                85                  90                  95      
Thr Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 633
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 633
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Leu
                85                  90                  95      
Asn Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 634
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 634
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Asn Glu
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 635
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 635
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Arg Glu Gly Val Tyr
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 636
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 636
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ala Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 637
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 637
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Arg Thr Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 638
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 638
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ala Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 639
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 639
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Tyr Glu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 640
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 640
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 641
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 641
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 642
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 642
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg Ile Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 643
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 643
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 644
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 644
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg His Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 645
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 645
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His His Thr Gly Arg Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 646
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 646
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Asn Glu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 647
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 647
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Phe Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 648
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 648
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Arg His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 649
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 649
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Ser His Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 650
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 650
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Val Ala Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 651
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 651
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Gln Lys Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 652
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 652
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Tyr Arg Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 653
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 653
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Glu Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 654
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 654
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Leu Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 655
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 655
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Leu Lys Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 656
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 656
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr His Gly Arg Val Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 657
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 657
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asn Gly Ala Thr Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 658
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 658
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Thr Arg Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 659
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 659
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Thr Ser Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 660
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 660
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Ser Ala Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 661
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 661
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Met Thr Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 662
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 662
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Arg Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 663
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 663
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Thr Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 664
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 664
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Glu Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 665
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 665
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Gly Arg Ser Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 666
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 666
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Glu Ser Cys
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 667
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 667
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Ser Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 668
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 668
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Arg Ala Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 669
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 669
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Gly Arg Gly Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 670
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 670
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Arg Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 671
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 671
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Phe Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 672
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 672
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Gly Val Asn Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 673
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 673
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Gly Gln Arg Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 674
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 674
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Gly Met Leu Asn
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 675
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 675
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Asp Gly Asn Glu Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 676
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 light chain variant

<400> 676
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Arg Glu Gly Val Tyr Ser
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 677
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DIQ 2G12 Variable Light Chain
      

<400> 677
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105         


<210> 678
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 678
Gln His Tyr Lys Pro Phe Met Ala Thr
 1               5                  


<210> 679
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 679
Gln His Tyr Gln Pro Phe Asp Ala Thr
 1               5                  


<210> 680
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 680
Gln His Tyr Arg Glu Trp His Ala Thr
 1               5                  


<210> 681
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 681
Gln His Tyr Leu Ser Tyr Asn Ala Thr
 1               5                  


<210> 682
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 682
Gln His Tyr Gln Pro Phe Lys Ala Thr
 1               5                  


<210> 683
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 683
Gln His Tyr Met Ala Tyr Asp Ala Thr
 1               5                  


<210> 684
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 684
Gln His Tyr Thr Ala His Asn Gly Ala Thr
 1               5                  10  


<210> 685
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 685
Gln His Tyr Thr Pro His Phe Gly Ala Thr
 1               5                  10  


<210> 686
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 686
Gln His Tyr Arg Ala His Ser Gly Ala Thr
 1               5                  10  


<210> 687
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 687
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Met
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 688
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 688
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 689
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 689
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 690
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 690
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ser Tyr Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 691
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 691
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 692
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 692
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Ala Tyr Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 693
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 693
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Asn
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 694
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 694
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Pro His Phe
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 695
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 695
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Ala His Ser
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 696
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 696
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Met Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 697
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 697
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 698
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 698
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp His Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 699
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 699
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ser Tyr Asn Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 700
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 700
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Lys Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 701
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 701
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Ala Tyr Asp Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 702
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 702
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Asn Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 703
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 703
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Pro His Phe Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 704
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 704
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Ala His Ser Gly
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 705
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 705
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactataagc cgtttatggc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 706
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 706
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatcagc cttttgatgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 707
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 707
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactataggg agtggcatgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 708
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 708
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatttgt cgtataatgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 709
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 709
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatcagc cttttaaggc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 710
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 710
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatatgg cttatgatgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 711
<211> 648
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 711
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatacgg ctcataatgg ggctaccttc 300
ggtcagggta cccgtgttga aatcaaacgt accgttgctg ctccgtctgt tttcatcttc 360
ccgccgtctg acgaacagct gaaatctggt accgcttctg ttgtttgcct gctgaacaac 420
ttctacccgc gtgaagctaa agttcagtgg aaagttgaca acgctctgca gtctggtaac 480
tctcaggaat ctgttaccga acaggactct aaagactcta cctactctct gtcttctacc 540
ctgaccctgt ctaaagctga ctacgaaaag cacaaagttt acgcttgcga agttacccac 600
cagggtctgt cttctccggt taccaaatct ttcaaccgtg gtgaatgc              648

<210> 712
<211> 648
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 712
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatacgc cgcattttgg tgctaccttc 300
ggtcagggta cccgtgttga aatcaaacgt accgttgctg ctccgtctgt tttcatcttc 360
ccgccgtctg acgaacagct gaaatctggt accgcttctg ttgtttgcct gctgaacaac 420
ttctacccgc gtgaagctaa agttcagtgg aaagttgaca acgctctgca gtctggtaac 480
tctcaggaat ctgttaccga acaggactct aaagactcta cctactctct gtcttctacc 540
ctgaccctgt ctaaagctga ctacgaaaag cacaaagttt acgcttgcga agttacccac 600
cagggtctgt cttctccggt taccaaatct ttcaaccgtg gtgaatgc              648

<210> 713
<211> 648
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 light chain variant

<400> 713
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcaaaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactatcggg cgcattcggg ggctaccttc 300
ggtcagggta cccgtgttga aatcaaacgt accgttgctg ctccgtctgt tttcatcttc 360
ccgccgtctg acgaacagct gaaatctggt accgcttctg ttgtttgcct gctgaacaac 420
ttctacccgc gtgaagctaa agttcagtgg aaagttgaca acgctctgca gtctggtaac 480
tctcaggaat ctgttaccga acaggactct aaagactcta cctactctct gtcttctacc 540
ctgaccctgt ctaaagctga ctacgaaaag cacaaagttt acgcttgcga agttacccac 600
cagggtctgt cttctccggt taccaaatct ttcaaccgtg gtgaatgc              648
