                         SEQUENCE LISTING

<110>  Novartis Forschungsstiftung, Zweigniederlassung Friedrich 
       Miescher Institute for Biomedical Research
 
<120>  Treating cancer by modulating MEX-3

<130>  PAT053794

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Leu Val Val Ser Gly Ile Met Glu Arg Asn Gly Gly Phe 
1               5                   10                  15      


Gly Glu Leu Gly Cys Phe Gly Gly Ser Ala Lys Asp Arg Gly Leu Leu 
            20                  25                  30          


Glu Asp Glu Arg Ala Leu Gln Leu Ala Leu Asp Gln Leu Cys Leu Leu 
        35                  40                  45              


Gly Leu Gly Glu Pro Pro Ala Pro Thr Ala Gly Glu Asp Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Ala Pro Ala Gln Pro Ala Ala Pro Pro Gln Pro Ala 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Ala Ala Pro Pro Ala Ala Pro Thr Ala Ala Pro 
                85                  90                  95      


Ala Ala Gln Thr Pro Gln Pro Pro Thr Ala Pro Lys Gly Ala Ser Asp 
            100                 105                 110         


Ala Lys Leu Cys Ala Leu Tyr Lys Glu Ala Glu Leu Arg Leu Lys Gly 
        115                 120                 125             


Ser Ser Asn Thr Thr Glu Cys Val Pro Val Pro Thr Ser Glu His Val 
    130                 135                 140                 


Ala Glu Ile Val Gly Arg Gln Gly Cys Lys Ile Lys Ala Leu Arg Ala 
145                 150                 155                 160 


Lys Thr Asn Thr Tyr Ile Lys Thr Pro Val Arg Gly Glu Glu Pro Val 
                165                 170                 175     


Phe Met Val Thr Gly Arg Arg Glu Asp Val Ala Thr Ala Arg Arg Glu 
            180                 185                 190         


Ile Ile Ser Ala Ala Glu His Phe Ser Met Ile Arg Ala Ser Arg Asn 
        195                 200                 205             


Lys Ser Gly Ala Ala Phe Gly Val Ala Pro Ala Leu Pro Gly Gln Val 
    210                 215                 220                 


Thr Ile Arg Val Arg Val Pro Tyr Arg Val Val Gly Leu Val Val Gly 
225                 230                 235                 240 


Pro Lys Gly Ala Thr Ile Lys Arg Ile Gln Gln Gln Thr Asn Thr Tyr 
                245                 250                 255     


Ile Ile Thr Pro Ser Arg Asp Arg Asp Pro Val Phe Glu Ile Thr Gly 
            260                 265                 270         


Ala Pro Gly Asn Val Glu Arg Ala Arg Glu Glu Ile Glu Thr His Ile 
        275                 280                 285             


Ala Val Arg Thr Gly Lys Ile Leu Glu Tyr Asn Asn Glu Asn Asp Phe 
    290                 295                 300                 


Leu Ala Gly Ser Pro Asp Ala Ala Ile Asp Ser Arg Tyr Ser Asp Ala 
305                 310                 315                 320 


Trp Arg Val His Gln Pro Gly Cys Lys Pro Leu Ser Thr Phe Arg Gln 
                325                 330                 335     


Asn Ser Leu Gly Cys Ile Gly Glu Cys Gly Val Asp Ser Gly Phe Glu 
            340                 345                 350         


Ala Pro Arg Leu Gly Glu Gln Gly Gly Asp Phe Gly Tyr Gly Gly Tyr 
        355                 360                 365             


Leu Phe Pro Gly Tyr Gly Val Gly Lys Gln Asp Val Tyr Tyr Gly Val 
    370                 375                 380                 


Ala Glu Thr Ser Pro Pro Leu Trp Ala Gly Gln Glu Asn Ala Thr Pro 
385                 390                 395                 400 


Thr Ser Val Leu Phe Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser Ala 
                405                 410                 415     


Lys Ala Arg Ala Gly Pro Pro Gly Ala His Arg Ser Pro Ala Thr Ser 
            420                 425                 430         


Ala Gly Pro Glu Leu Ala Gly Leu Pro Arg Arg Pro Pro Gly Glu Pro 
        435                 440                 445             


Leu Gln Gly Phe Ser Lys Leu Gly Gly Gly Gly Leu Arg Ser Pro Gly 
    450                 455                 460                 


Gly Gly Arg Asp Cys Met Val Cys Phe Glu Ser Glu Val Thr Ala Ala 
465                 470                 475                 480 


Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys Ala Val Arg 
                485                 490                 495     


Ile Cys Glu Arg Thr Asp Pro Glu Cys Pro Val Cys His Ile Thr Ala 
            500                 505                 510         


Thr Gln Ala Ile Arg Ile Phe Ser 
        515                 520 


<210>  2
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ser Ser Leu Phe Ala Asp Leu Glu Arg Asn Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Gly Gly Gly Glu Thr Leu Asp Asp Gln Arg 
            20                  25                  30          


Ala Leu Gln Leu Ala Leu Asp Gln Leu Ser Leu Leu Gly Leu Asp Ser 
        35                  40                  45              


Asp Glu Gly Ala Ser Leu Tyr Asp Ser Glu Pro Arg Lys Lys Ser Val 
    50                  55                  60                  


Asn Met Thr Glu Cys Val Pro Val Pro Ser Ser Glu His Val Ala Glu 
65                  70                  75                  80  


Ile Val Gly Arg Gln Gly Cys Lys Ile Lys Ala Leu Arg Ala Lys Thr 
                85                  90                  95      


Asn Thr Tyr Ile Lys Thr Pro Val Arg Gly Glu Glu Pro Val Phe Val 
            100                 105                 110         


Val Thr Gly Arg Lys Glu Asp Val Ala Met Ala Arg Arg Glu Ile Ile 
        115                 120                 125             


Ser Ala Ala Glu His Phe Ser Met Ile Arg Ala Ser Arg Asn Lys Asn 
    130                 135                 140                 


Thr Ala Leu Asn Gly Ala Val Pro Gly Pro Pro Asn Leu Pro Gly Gln 
145                 150                 155                 160 


Thr Thr Ile Gln Val Arg Val Pro Tyr Arg Val Val Gly Leu Val Val 
                165                 170                 175     


Gly Pro Lys Gly Ala Thr Ile Lys Arg Ile Gln Gln Gln Thr His Thr 
            180                 185                 190         


Tyr Ile Val Thr Pro Ser Arg Asp Lys Glu Pro Val Phe Glu Val Thr 
        195                 200                 205             


Gly Met Pro Glu Asn Val Asp Arg Ala Arg Glu Glu Ile Glu Ala His 
    210                 215                 220                 


Ile Ala Leu Arg Thr Gly Gly Ile Ile Glu Leu Thr Asp Glu Asn Asp 
225                 230                 235                 240 


Phe His Ala Asn Gly Thr Asp Val Gly Phe Asp Leu His His Gly Ser 
                245                 250                 255     


Gly Gly Ser Gly Pro Gly Ser Leu Trp Ser Lys Pro Thr Pro Ser Ile 
            260                 265                 270         


Thr Pro Thr Pro Gly Arg Lys Pro Phe Ser Ser Tyr Arg Asn Asp Ser 
        275                 280                 285             


Ser Ser Ser Leu Gly Ser Ala Ser Thr Asp Ser Tyr Phe Gly Gly Gly 
    290                 295                 300                 


Thr Ser Ser Ser Ala Ala Ala Thr Gln Arg Leu Ala Asp Tyr Ser Pro 
305                 310                 315                 320 


Pro Ser Pro Ala Leu Ser Phe Ala His Asn Gly Asn Asn Asn Asn Asn 
                325                 330                 335     


Gly Asn Gly Tyr Thr Tyr Thr Ala Gly Gly Glu Ala Ser Val Pro Ser 
            340                 345                 350         


Pro Asp Gly Cys Pro Glu Leu Gln Pro Thr Phe Asp Pro Ala Pro Ala 
        355                 360                 365             


Pro Pro Pro Gly Ala Pro Leu Ile Trp Ala Gln Phe Glu Arg Ser Pro 
    370                 375                 380                 


Gly Gly Gly Pro Ala Ala Pro Val Ser Ser Ser Cys Ser Ser Ser Ala 
385                 390                 395                 400 


Ser Ser Ser Ala Ser Ser Ser Ser Val Val Phe Pro Gly Gly Gly Ala 
                405                 410                 415     


Ser Ala Pro Ser Asn Ala Asn Leu Gly Leu Leu Val His Arg Arg Leu 
            420                 425                 430         


His Pro Gly Thr Ser Cys Pro Arg Leu Ser Pro Pro Leu His Met Ala 
        435                 440                 445             


Pro Gly Ala Gly Glu His His Leu Ala Arg Arg Val Arg Ser Asp Pro 
    450                 455                 460                 


Gly Gly Gly Gly Leu Ala Tyr Ala Ala Tyr Ala Asn Gly Leu Gly Ala 
465                 470                 475                 480 


Gln Leu Pro Gly Leu Gln Pro Ser Asp Thr Ser Gly Ser Ser Ser Ser 
                485                 490                 495     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Leu Arg Arg 
            500                 505                 510         


Lys Gly Ser Arg Asp Cys Ser Val Cys Phe Glu Ser Glu Val Ile Ala 
        515                 520                 525             


Ala Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys Ala Asn 
    530                 535                 540                 


Arg Ile Cys Glu Lys Ser Glu Pro Glu Cys Pro Val Cys His Thr Ala 
545                 550                 555                 560 


Val Thr Gln Ala Ile Arg Ile Phe Ser 
                565                 


<210>  3
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Ser Gly Ser Ser Ala Ala Leu Ala Leu Ala Ala Ala Pro Ala 
1               5                   10                  15      


Pro Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            20                  25                  30          


Pro Pro Pro Ser Gly Gly Pro Glu Leu Glu Gly Asp Gly Leu Leu Leu 
        35                  40                  45              


Arg Glu Arg Leu Ala Ala Leu Gly Leu Asp Asp Pro Ser Pro Ala Glu 
    50                  55                  60                  


Pro Gly Ala Pro Ala Leu Arg Ala Pro Ala Ala Ala Ala Gln Gly Gln 
65                  70                  75                  80  


Ala Arg Arg Ala Ala Glu Leu Ser Pro Glu Glu Arg Ala Pro Pro Gly 
                85                  90                  95      


Arg Pro Gly Ala Pro Glu Ala Ala Glu Leu Glu Leu Glu Glu Asp Glu 
            100                 105                 110         


Glu Glu Gly Glu Glu Ala Glu Leu Asp Gly Asp Leu Leu Glu Glu Glu 
        115                 120                 125             


Glu Leu Glu Glu Ala Glu Glu Glu Asp Arg Ser Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Pro Pro Ala Ala Thr Ala Ser Gln Thr Gln Gln Ile Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Gly Ser Val Leu Leu Pro Ala Ala Arg Phe Asp Ala Arg Glu 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Leu Tyr Gly Gly Asp Asp 
            180                 185                 190         


Ala Gln Gly Met Met Ala Ala Met Leu Ser His Ala Tyr Gly Pro Gly 
        195                 200                 205             


Gly Cys Gly Ala Ala Ala Ala Ala Leu Asn Gly Glu Gln Ala Ala Leu 
    210                 215                 220                 


Leu Arg Arg Lys Ser Val Asn Thr Thr Glu Cys Val Pro Val Pro Ser 
225                 230                 235                 240 


Ser Glu His Val Ala Glu Ile Val Gly Arg Gln Gly Cys Lys Ile Lys 
                245                 250                 255     


Ala Leu Arg Ala Lys Thr Asn Thr Tyr Ile Lys Thr Pro Val Arg Gly 
            260                 265                 270         


Glu Glu Pro Ile Phe Val Val Thr Gly Arg Lys Glu Asp Val Ala Met 
        275                 280                 285             


Ala Lys Arg Glu Ile Leu Ser Ala Ala Glu His Phe Ser Met Ile Arg 
    290                 295                 300                 


Ala Ser Arg Asn Lys Asn Gly Pro Ala Leu Gly Gly Leu Ser Cys Ser 
305                 310                 315                 320 


Pro Asn Leu Pro Gly Gln Thr Thr Val Gln Val Arg Val Pro Tyr Arg 
                325                 330                 335     


Val Val Gly Leu Val Val Gly Pro Lys Gly Ala Thr Ile Lys Arg Ile 
            340                 345                 350         


Gln Gln Gln Thr His Thr Tyr Ile Val Thr Pro Ser Arg Asp Lys Glu 
        355                 360                 365             


Pro Val Phe Glu Val Thr Gly Met Pro Glu Asn Val Asp Arg Ala Arg 
    370                 375                 380                 


Glu Glu Ile Glu Met His Ile Ala Met Arg Thr Gly Asn Tyr Ile Glu 
385                 390                 395                 400 


Leu Asn Glu Glu Asn Asp Phe His Tyr Asn Gly Thr Asp Val Ser Phe 
                405                 410                 415     


Glu Gly Gly Thr Leu Gly Ser Ala Trp Leu Ser Ser Asn Pro Val Pro 
            420                 425                 430         


Pro Ser Arg Ala Arg Met Ile Ser Asn Tyr Arg Asn Asp Ser Ser Ser 
        435                 440                 445             


Ser Leu Gly Ser Gly Ser Thr Asp Ser Tyr Phe Gly Ser Asn Arg Leu 
    450                 455                 460                 


Ala Asp Phe Ser Pro Thr Ser Pro Phe Ser Thr Gly Asn Phe Trp Phe 
465                 470                 475                 480 


Gly Asp Thr Leu Pro Ser Val Gly Ser Glu Asp Leu Ala Val Asp Ser 
                485                 490                 495     


Pro Ala Phe Asp Ser Leu Pro Thr Ser Ala Gln Thr Ile Trp Thr Pro 
            500                 505                 510         


Phe Glu Pro Val Asn Pro Leu Ser Gly Phe Gly Ser Asp Pro Ser Gly 
        515                 520                 525             


Asn Met Lys Thr Gln Arg Arg Gly Ser Gln Pro Ser Thr Pro Arg Leu 
    530                 535                 540                 


Ser Pro Thr Phe Pro Glu Ser Ile Glu His Pro Leu Ala Arg Arg Val 
545                 550                 555                 560 


Arg Ser Asp Pro Pro Ser Thr Gly Asn His Val Gly Leu Pro Ile Tyr 
                565                 570                 575     


Ile Pro Ala Phe Ser Asn Gly Thr Asn Ser Tyr Ser Ser Ser Asn Gly 
            580                 585                 590         


Gly Ser Thr Ser Ser Ser Pro Pro Glu Ser Arg Arg Lys His Asp Cys 
        595                 600                 605             


Val Ile Cys Phe Glu Asn Glu Val Ile Ala Ala Leu Val Pro Cys Gly 
    610                 615                 620                 


His Asn Leu Phe Cys Met Glu Cys Ala Asn Lys Ile Cys Glu Lys Arg 
625                 630                 635                 640 


Thr Pro Ser Cys Pro Val Cys Gln Thr Ala Val Thr Gln Ala Ile Gln 
                645                 650                 655     


Ile His Ser 
            


<210>  4
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ser Ser Leu Gly Gln Pro Asp Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Val Gly Ala Ala Gly Glu Asp Pro Gly Pro Gly Pro 
            20                  25                  30          


Ala Pro Pro Pro Glu Gly Ala Gln Glu Ala Ala Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Pro Glu Pro Asp Asp Ala Ala Ala Ala Leu Arg Leu Ala Leu Asp 
    50                  55                  60                  


Gln Leu Ser Ala Leu Gly Leu Gly Gly Ala Gly Asp Thr Asp Glu Glu 
65                  70                  75                  80  


Gly Ala Ala Gly Asp Gly Ala Ala Ala Ala Gly Gly Ala Asp Gly Gly 
                85                  90                  95      


Ala Ala Pro Glu Pro Val Pro Pro Asp Gly Pro Glu Ala Gly Ala Pro 
            100                 105                 110         


Pro Thr Leu Ala Pro Ala Val Ala Pro Gly Ser Leu Pro Leu Leu Asp 
        115                 120                 125             


Pro Asn Ala Ser Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Pro Pro 
    130                 135                 140                 


Asp Val Phe Ala Gly Phe Ala Pro His Pro Ala Ala Leu Gly Pro Pro 
145                 150                 155                 160 


Thr Leu Leu Ala Asp Gln Met Ser Val Ile Gly Ser Arg Lys Lys Ser 
                165                 170                 175     


Val Asn Met Thr Glu Cys Val Pro Val Pro Ser Ser Glu His Val Ala 
            180                 185                 190         


Glu Ile Val Gly Arg Gln Gly Cys Lys Ile Lys Ala Leu Arg Ala Lys 
        195                 200                 205             


Thr Asn Thr Tyr Ile Lys Thr Pro Val Arg Gly Glu Glu Pro Val Phe 
    210                 215                 220                 


Ile Val Thr Gly Arg Lys Glu Asp Val Glu Met Ala Lys Arg Glu Ile 
225                 230                 235                 240 


Leu Ser Ala Ala Glu His Phe Ser Ile Ile Arg Ala Thr Arg Ser Lys 
                245                 250                 255     


Ala Gly Gly Leu Pro Gly Ala Ala Gln Gly Pro Pro Asn Leu Pro Gly 
            260                 265                 270         


Gln Thr Thr Ile Gln Val Arg Val Pro Tyr Arg Val Val Gly Leu Val 
        275                 280                 285             


Val Gly Pro Lys Gly Ala Thr Ile Lys Arg Ile Gln Gln Arg Thr His 
    290                 295                 300                 


Thr Tyr Ile Val Thr Pro Gly Arg Asp Lys Glu Pro Val Phe Ala Val 
305                 310                 315                 320 


Thr Gly Met Pro Glu Asn Val Asp Arg Ala Arg Glu Glu Ile Glu Ala 
                325                 330                 335     


His Ile Thr Leu Arg Thr Gly Ala Phe Thr Asp Ala Gly Pro Asp Ser 
            340                 345                 350         


Asp Phe His Ala Asn Gly Thr Asp Val Cys Leu Asp Leu Leu Gly Ala 
        355                 360                 365             


Ala Ala Ser Leu Trp Ala Lys Thr Pro Asn Gln Gly Arg Arg Pro Pro 
    370                 375                 380                 


Thr Ala Thr Ala Gly Leu Arg Gly Asp Thr Ala Leu Gly Ala Pro Ser 
385                 390                 395                 400 


Ala Pro Glu Ala Phe Tyr Ala Gly Ser Arg Gly Gly Pro Ser Val Pro 
                405                 410                 415     


Asp Pro Gly Pro Ala Ser Pro Tyr Ser Gly Ser Gly Asn Gly Gly Phe 
            420                 425                 430         


Ala Phe Gly Ala Glu Gly Pro Gly Ala Pro Val Gly Thr Ala Ala Pro 
        435                 440                 445             


Asp Asp Cys Asp Phe Gly Phe Asp Phe Asp Phe Leu Ala Leu Asp Leu 
    450                 455                 460                 


Thr Val Pro Ala Ala Ala Thr Ile Trp Ala Pro Phe Glu Arg Ala Ala 
465                 470                 475                 480 


Pro Leu Pro Ala Phe Ser Gly Cys Ser Thr Val Asn Gly Ala Pro Gly 
                485                 490                 495     


Pro Pro Ala Ala Gly Ala Arg Arg Ser Ser Gly Ala Gly Thr Pro Arg 
            500                 505                 510         


His Ser Pro Thr Leu Pro Glu Pro Gly Gly Leu Arg Leu Glu Leu Pro 
        515                 520                 525             


Leu Ser Arg Arg Gly Ala Pro Asp Pro Val Gly Ala Leu Ser Trp Arg 
    530                 535                 540                 


Pro Pro Gln Gly Pro Val Ser Phe Pro Gly Gly Ala Ala Phe Ser Thr 
545                 550                 555                 560 


Ala Thr Ser Leu Pro Ser Ser Pro Ala Ala Ala Ala Cys Ala Pro Leu 
                565                 570                 575     


Asp Ser Gly Ala Ser Glu Asn Ser Arg Lys Pro Pro Ser Ala Ser Ser 
            580                 585                 590         


Ala Pro Ala Leu Ala Arg Glu Cys Val Val Cys Ala Glu Gly Glu Val 
        595                 600                 605             


Met Ala Ala Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Asp Cys 
    610                 615                 620                 


Ala Val Arg Ile Cys Gly Lys Ser Glu Pro Glu Cys Pro Ala Cys Arg 
625                 630                 635                 640 


Thr Pro Ala Thr Gln Ala Ile His Ile Phe Ser 
                645                 650     


