
                                SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Zhang, Ningyan
      Huber, Hans

<120> GENERATION, CHARACTERIZATION AND USES
  THEREOF OF ANTI-HER 3 ANTIBODIES
  

<130> MRL-ONC-00009

<150> 61/250,060          
<151> 2009-10-09  

<160> 98

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1342
<212> PRT
<213> Artificial Sequence

<220> 
<223> cDNA and proteins encoding a human protein

<400> 1
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu
 1               5                  10                  15      
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr
            20                  25                  30          
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr
        35                  40                  45              
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr
                85                  90                  95      
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp
            100                 105                 110         
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser
        115                 120                 125             
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser
    130                 135                 140                 
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr
145                 150                 155                 160 
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val
                165                 170                 175     
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly
            180                 185                 190         
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr
        195                 200                 205             
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn
    210                 215                 220                 
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp
225                 230                 235                 240 
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val
                245                 250                 255     
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu
            260                 265                 270         
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala
        275                 280                 285             
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala
    290                 295                 300                 
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys
305                 310                 315                 320 
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser
                325                 330                 335     
Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val
            340                 345                 350         
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu
        355                 360                 365             
Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu
    370                 375                 380                 
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln
385                 390                 395                 400 
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr
                405                 410                 415     
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile
            420                 425                 430         
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu
        435                 440                 445             
Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr
    450                 455                 460                 
His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu
465                 470                 475                 480 
Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu
                485                 490                 495     
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro
            500                 505                 510         
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val
        515                 520                 525             
Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala
    530                 535                 540                 
His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu
545                 550                 555                 560 
Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys
                565                 570                 575     
Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly
            580                 585                 590         
Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn
        595                 600                 605             
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro
    610                 615                 620                 
Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr
625                 630                 635                 640 
His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe
                645                 650                 655     
Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln
            660                 665                 670         
Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu
        675                 680                 685             
Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe
    690                 695                 700                 
Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe
705                 710                 715                 720 
Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys
                725                 730                 735     
Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser
            740                 745                 750         
Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His
        755                 760                 765             
Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln
    770                 775                 780                 
Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg
785                 790                 795                 800 
Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val
                805                 810                 815     
Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His
            820                 825                 830         
Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val
        835                 840                 845             
Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys
    850                 855                 860                 
Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu
865                 870                 875                 880 
Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser
                885                 890                 895     
Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr
            900                 905                 910         
Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu
        915                 920                 925             
Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met
    930                 935                 940                 
Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu
945                 950                 955                 960 
Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu
                965                 970                 975     
Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro
            980                 985                 990         
His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu
        995                 1000                1005            
Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr
    1010                1015                1020                
Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg
1025                1030                1035                1040
Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro
                1045                1050                1055    
Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser
            1060                1065                1070        
Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro
        1075                1080                1085            
Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser
    1090                1095                1100                
Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg
1105                1110                1115                1120
Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg
                1125                1130                1135    
His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu
            1140                1145                1150        
Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly
        1155                1160                1165            
Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser
    1170                1175                1180                
Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met
1185                1190                1195                1200
Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser
                1205                1210                1215    
Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser
            1220                1225                1230        
Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile
        1235                1240                1245            
Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn
    1250                1255                1260                
Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly
1265                1270                1275                1280
Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln
                1285                1290                1295    
Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr
            1300                1305                1310        
Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr
        1315                1320                1325            
Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr
    1330                1335                1340        


<210> 2
<211> 4975
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA and proteins encoding a human protein

<400> 2
ctctcacaca cacacacccc tcccctgcca tccctccccg gactccggct ccggctccga 60
ttgcaatttg caacctccgc tgccgtcgcc gcagcagcca ccaattcgcc agcggttcag 120
gtggctcttg cctcgatgtc ctagcctagg ggcccccggg ccggacttgg ctgggctccc 180
ttcaccctct gcggagtcat gagggcgaac gacgctctgc aggtgctggg cttgcttttc 240
agcctggccc ggggctccga ggtgggcaac tctcaggcag tgtgtcctgg gactctgaat 300
ggcctgagtg tgaccggcga tgctgagaac caataccaga cactgtacaa gctctacgag 360
aggtgtgagg tggtgatggg gaaccttgag attgtgctca cgggacacaa tgccgacctc 420
tccttcctgc agtggattcg agaagtgaca ggctatgtcc tcgtggccat gaatgaattc 480
tctactctac cattgcccaa cctccgcgtg gtgcgaggga cccaggtcta cgatgggaag 540
tttgccatct tcgtcatgtt gaactataac accaactcca gccacgctct gcgccagctc 600
cgcttgactc agctcaccga gattctgtca gggggtgttt atattgagaa gaacgataag 660
ctttgtcaca tggacacaat tgactggagg gacatcgtga gggaccgaga tgctgagata 720
gtggtgaagg acaatggcag aagctgtccc ccctgtcatg aggtttgcaa ggggcgatgc 780
tggggtcctg gatcagaaga ctgccagaca ttgaccaaga ccatctgtgc tcctcagtgt 840
aatggtcact gctttgggcc caaccccaac cagtgctgcc atgatgagtg tgccgggggc 900
tgctcaggcc ctcaggacac agactgcttt gcctgccggc acttcaatga cagtggagcc 960
tgtgtacctc gctgtccaca gcctcttgtc tacaacaagc taactttcca gctggaaccc 1020
aatccccaca ccaagtatca gtatggagga gtttgtgtag ccagctgtcc ccataacttt 1080
gtggtggatc aaacatcctg tgtcagggcc tgtcctcctg acaagatgga agtagataaa 1140
aatgggctca agatgtgtga gccttgtggg ggactatgtc ccaaagcctg tgagggaaca 1200
ggctctggga gccgcttcca gactgtggac tcgagcaaca ttgatggatt tgtgaactgc 1260
accaagatcc tgggcaacct ggactttctg atcaccggcc tcaatggaga cccctggcac 1320
aagatccctg ccctggaccc agagaagctc aatgtcttcc ggacagtacg ggagatcaca 1380
ggttacctga acatccagtc ctggccgccc cacatgcaca acttcagtgt tttttccaat 1440
ttgacaacca ttggaggcag aagcctctac aaccggggct tctcattgtt gatcatgaag 1500
aacttgaatg tcacatctct gggcttccga tccctgaagg aaattagtgc tgggcgtatc 1560
tatataagtg ccaataggca gctctgctac caccactctt tgaactggac caaggtgctt 1620
cgggggccta cggaagagcg actagacatc aagcataatc ggccgcgcag agactgcgtg 1680
gcagagggca aagtgtgtga cccactgtgc tcctctgggg gatgctgggg cccaggccct 1740
ggtcagtgct tgtcctgtcg aaattatagc cgaggaggtg tctgtgtgac ccactgcaac 1800
tttctgaatg gggagcctcg agaatttgcc catgaggccg aatgcttctc ctgccacccg 1860
gaatgccaac ccatgggggg cactgccaca tgcaatggct cgggctctga tacttgtgct 1920
caatgtgccc attttcgaga tgggccccac tgtgtgagca gctgccccca tggagtccta 1980
ggtgccaagg gcccaatcta caagtaccca gatgttcaga atgaatgtcg gccctgccat 2040
gagaactgca cccaggggtg taaaggacca gagcttcaag actgtttagg acaaacactg 2100
gtgctgatcg gcaaaaccca tctgacaatg gctttgacag tgatagcagg attggtagtg 2160
attttcatga tgctgggcgg cacttttctc tactggcgtg ggcgccggat tcagaataaa 2220
agggctatga ggcgatactt ggaacggggt gagagcatag agcctctgga ccccagtgag 2280
aaggctaaca aagtcttggc cagaatcttc aaagagacag agctaaggaa gcttaaagtg 2340
cttggctcgg gtgtctttgg aactgtgcac aaaggagtgt ggatccctga gggtgaatca 2400
atcaagattc cagtctgcat taaagtcatt gaggacaaga gtggacggca gagttttcaa 2460
gctgtgacag atcatatgct ggccattggc agcctggacc atgcccacat tgtaaggctg 2520
ctgggactat gcccagggtc atctctgcag cttgtcactc aatatttgcc tctgggttct 2580
ctgctggatc atgtgagaca acaccggggg gcactggggc cacagctgct gctcaactgg 2640
ggagtacaaa ttgccaaggg aatgtactac cttgaggaac atggtatggt gcatagaaac 2700
ctggctgccc gaaacgtgct actcaagtca cccagtcagg ttcaggtggc agattttggt 2760
gtggctgacc tgctgcctcc tgatgataag cagctgctat acagtgaggc caagactcca 2820
attaagtgga tggcccttga gagtatccac tttgggaaat acacacacca gagtgatgtc 2880
tggagctatg gtgtgacagt ttgggagttg atgaccttcg gggcagagcc ctatgcaggg 2940
ctacgattgg ctgaagtacc agacctgcta gagaaggggg agcggttggc acagccccag 3000
atctgcacaa ttgatgtcta catggtgatg gtcaagtgtt ggatgattga tgagaacatt 3060
cgcccaacct ttaaagaact agccaatgag ttcaccagga tggcccgaga cccaccacgg 3120
tatctggtca taaagagaga gagtgggcct ggaatagccc ctgggccaga gccccatggt 3180
ctgacaaaca agaagctaga ggaagtagag ctggagccag aactagacct agacctagac 3240
ttggaagcag aggaggacaa cctggcaacc accacactgg gctccgccct cagcctacca 3300
gttggaacac ttaatcggcc acgtgggagc cagagccttt taagtccatc atctggatac 3360
atgcccatga accagggtaa tcttgggggg tcttgccagg agtctgcagt ttctgggagc 3420
agtgaacggt gcccccgtcc agtctctcta cacccaatgc cacggggatg cctggcatca 3480
gagtcatcag aggggcatgt aacaggctct gaggctgagc tccaggagaa agtgtcaatg 3540
tgtagaagcc ggagcaggag ccggagccca cggccacgcg gagatagcgc ctaccattcc 3600
cagcgccaca gtctgctgac tcctgttacc ccactctccc cacccgggtt agaggaagag 3660
gatgtcaacg gttatgtcat gccagataca cacctcaaag gtactccctc ctcccgggaa 3720
ggcacccttt cttcagtggg tctcagttct gtcctgggta ctgaagaaga agatgaagat 3780
gaggagtatg aatacatgaa ccggaggaga aggcacagtc cacctcatcc ccctaggcca 3840
agttcccttg aggagctggg ttatgagtac atggatgtgg ggtcagacct cagtgcctct 3900
ctgggcagca cacagagttg cccactccac cctgtaccca tcatgcccac tgcaggcaca 3960
actccagatg aagactatga atatatgaat cggcaacgag atggaggtgg tcctgggggt 4020
gattatgcag ccatgggggc ctgcccagca tctgagcaag ggtatgaaga gatgagagct 4080
tttcaggggc ctggacatca ggccccccat gtccattatg cccgcctaaa aactctacgt 4140
agcttagagg ctacagactc tgcctttgat aaccctgatt actggcatag caggcttttc 4200
cccaaggcta atgcccagag aacgtaactc ctgctccctg tggcactcag ggagcattta 4260
atggcagcta gtgcctttag agggtaccgt cttctcccta ttccctctct ctcccaggtc 4320
ccagcccctt ttccccagtc ccagacaatt ccattcaatc tttggaggct tttaaacatt 4380
ttgacacaaa attcttatgg tatgtagcca gctgtgcact ttcttctctt tcccaacccc 4440
aggaaaggtt ttccttattt tgtgtgcttt cccagtccca ttcctcagct tcttcacagg 4500
cactcctgga gatatgaagg attactctcc atatcccttc ctctcaggct cttgactact 4560
tggaactagg ctcttatgtg tgcctttgtt tcccatcaga ctgtcaagaa gaggaaaggg 4620
aggaaaccta gcagaggaaa gtgtaatttt ggtttatgac tcttaacccc ctagaaagac 4680
agaagcttaa aatctgtgaa gaaagaggtt aggagtagat attgattact atcataattc 4740
agcacttaac tatgagccag gcatcatact aaacttcacc tacattatct cacttagtcc 4800
tttatcatcc ttaaaacaat tctgtgacat acatattatc tcattttaca caaagggaag 4860
tcgggcatgg tggctcatgc ctgtaatctc agcactttgg gaggctgagg cagaaggatt 4920
acctgaggca aggagtttga gaccagctta gccaacatag taagaccccc atctc      4975

<210> 3
<211> 8
<212> PRT
<213> Mus Musculus

<400> 3
Gly Tyr Thr Phe Thr Asp Tyr Gly
 1               5              


<210> 4
<211> 7
<212> PRT
<213> Mus Musculus

<400> 4
Ile Thr Ile Tyr Asp Gly His
 1               5          


<210> 5
<211> 13
<212> PRT
<213> Mus Musculus

<400> 5
Ala Arg Gly Asp Tyr Asp Leu Phe Trp Tyr Leu Asp Val
 1               5                  10              


<210> 6
<211> 8
<212> PRT
<213> Mus Musculus

<400> 6
Gly Tyr Thr Phe Thr Asn Ser Trp
 1               5              


<210> 7
<211> 7
<212> PRT
<213> Mus Musculus

<400> 7
Ile His Pro Asn Ser Gly Asn
 1               5          


<210> 8
<211> 6
<212> PRT
<213> Mus Musculus

<400> 8
Ala Arg Tyr Glu Gly His
 1               5      


<210> 9
<211> 8
<212> PRT
<213> Mus Musculus

<400> 9
Gly Tyr Thr Phe Thr Ser Tyr Val
 1               5              


<210> 10
<211> 7
<212> PRT
<213> Mus Musculus

<400> 10
Ile Asn Pro Tyr Asn Asp Gly
 1               5          


<210> 11
<211> 12
<212> PRT
<213> Mus Musculus

<400> 11
Ala Arg Glu Ala Ser Tyr Gly Asn Pro Phe Ala Tyr
 1               5                  10          


<210> 12
<211> 8
<212> PRT
<213> Mus Musculus

<400> 12
Gly Tyr Ser Phe Thr Gly Tyr Tyr
 1               5              


<210> 13
<211> 7
<212> PRT
<213> Mus Musculus

<400> 13
Ile Asn Pro Tyr Tyr Gly Gly
 1               5          


<210> 14
<211> 12
<212> PRT
<213> Mus Musculus

<400> 14
Ala Arg Lys Gly Asp Leu Tyr Tyr Ser Met Asp Tyr
 1               5                  10          


<210> 15
<211> 9
<212> PRT
<213> Mus Musculus

<400> 15
Gly Tyr Ser Ile Thr Ser Asp Tyr Ala
 1               5                  


<210> 16
<211> 6
<212> PRT
<213> Mus Musculus

<400> 16
Ile Asn Tyr Ser Gly Ser
 1               5      


<210> 17
<211> 12
<212> PRT
<213> Mus Musculus

<400> 17
Ala Arg Asp Asp Tyr Asp Gly Tyr Tyr Phe Asp Tyr
 1               5                  10          


<210> 18
<211> 8
<212> PRT
<213> Mus Musculus

<400> 18
Gly Tyr Thr Phe Thr Ile Phe Trp
 1               5              


<210> 19
<211> 7
<212> PRT
<213> Mus Musculus

<400> 19
Ile Tyr Pro Gly Ser Gly Gly
 1               5          


<210> 20
<211> 9
<212> PRT
<213> Mus Musculus

<400> 20
Thr Arg Trp Gly Thr Gly Lys Asp Tyr
 1               5                  


<210> 21
<211> 10
<212> PRT
<213> Mus Musculus

<400> 21
Gly Phe Ser Leu Ser Thr Tyr Gly Met Gly
 1               5                  10  


<210> 22
<211> 6
<212> PRT
<213> Mus Musculus

<400> 22
Ile Trp Trp Asn Asp Asp
 1               5      


<210> 23
<211> 12
<212> PRT
<213> Mus Musculus

<400> 23
Val Gln Ile Ala Asn Pro Tyr Trp Tyr Phe Asp Val
 1               5                  10          


<210> 24
<211> 8
<212> PRT
<213> Mus Musculus

<400> 24
Gly Tyr Ser Phe Thr Gly Tyr His
 1               5              


<210> 25
<211> 7
<212> PRT
<213> Mus Musculus

<400> 25
Ile Asn Pro Tyr Ser Gly Val
 1               5          


<210> 26
<211> 12
<212> PRT
<213> Mus Musculus

<400> 26
Ala Arg Thr Asp Tyr Tyr Gly Pro Trp Phe Ala Tyr
 1               5                  10          


<210> 27
<211> 11
<212> PRT
<213> Mus Musculus

<400> 27
Gln Asn Ile Lys His Ser Asp Gly Asn Thr Tyr
 1               5                  10      


<210> 28
<211> 2
<212> PRT
<213> Mus Musculus

<400> 28
Lys Val
 1      


<210> 29
<211> 9
<212> PRT
<213> Mus Musculus

<400> 29
Phe Gln Gly Ser His Val Pro Leu Thr
 1               5                  


<210> 30
<211> 11
<212> PRT
<213> Mus Musculus

<400> 30
Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr
 1               5                  10      


<210> 31
<211> 2
<212> PRT
<213> Mus Musculus

<400> 31
Leu Val
 1      


<210> 32
<211> 9
<212> PRT
<213> Mus Musculus

<400> 32
Trp Gln Gly Thr His Phe Pro Gln Thr
 1               5                  


<210> 33
<211> 6
<212> PRT
<213> Mus Musculus

<400> 33
Glu Asn Ile Tyr Ser Tyr
 1               5      


<210> 34
<211> 2
<212> PRT
<213> Mus Musculus

<400> 34
Asn Thr
 1      


<210> 35
<211> 9
<212> PRT
<213> Mus Musculus

<400> 35
Gln His His Tyr Asp Thr Pro Trp Thr
 1               5                  


<210> 36
<211> 11
<212> PRT
<213> Mus Musculus

<400> 36
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 37
<211> 2
<212> PRT
<213> Mus Musculus

<400> 37
Lys Val
 1      


<210> 38
<211> 9
<212> PRT
<213> Mus Musculus

<400> 38
Phe Gln Gly Ser His Val Pro Pro Thr
 1               5                  


<210> 39
<211> 10
<212> PRT
<213> Mus Musculus

<400> 39
Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr
 1               5                  10  


<210> 40
<211> 2
<212> PRT
<213> Mus Musculus

<400> 40
Leu Val
 1      


<210> 41
<211> 8
<212> PRT
<213> Mus Musculus

<400> 41
Gln His Ile Arg Glu Leu Thr Arg
 1               5              


<210> 42
<211> 7
<212> PRT
<213> Mus Musculus

<400> 42
Ser Ser Val Ser Ser Ser Tyr
 1               5          


<210> 43
<211> 2
<212> PRT
<213> Mus Musculus

<400> 43
Ser Thr
 1      


<210> 44
<211> 9
<212> PRT
<213> Mus Musculus

<400> 44
Gln Gln Tyr Asp Ser Ser Pro Phe Thr
 1               5                  


<210> 45
<211> 10
<212> PRT
<213> Mus Musculus

<400> 45
Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr
 1               5                  10  


<210> 46
<211> 2
<212> PRT
<213> Mus Musculus

<400> 46
Leu Val
 1      


<210> 47
<211> 8
<212> PRT
<213> Mus Musculus

<400> 47
Gln His Ile Arg Glu Leu Thr Arg
 1               5              


<210> 48
<211> 11
<212> PRT
<213> Mus Musculus

<400> 48
Pro Ser Leu Val His Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 49
<211> 2
<212> PRT
<213> Mus Musculus

<400> 49
Thr Val
 1      


<210> 50
<211> 9
<212> PRT
<213> Mus Musculus

<400> 50
Ser Gln Thr Thr His Val Pro Trp Thr
 1               5                  


<210> 51
<211> 383
<212> DNA
<213> Mus Musculus

<400> 51
ctcgaggagg tgcagcttca gcagtctggg cctaaactgg tggggcctgg ggaatcagtg 60
aagatttcct gcaagggttc cggctacaca ttcactgatt acggtatgca ctgggtgaaa 120
cagagtcatg caaagaggct cgagtggatt ggagttatca ctatttatga tggtcataca 180
aactacaacc agaactttaa gggcaaggcc gcattgactg tagacaaatc ctccaacaca 240
gcctatctgg aacttgccag aatgacttct gaggattctg ccatctatta ctgtgcaagg 300
ggagattacg acctcttctg gtatttggat gtctggggcg cagggaccac tctcacagtc 360
tcctcggcct ccaccaaggg ccc                                         383

<210> 52
<211> 348
<212> DNA
<213> Mus Musculus

<400> 52
tctagagatg ttgtgatgac ccagactcca ctctccctga ctgtcagtct tggagatcaa 60
gcctccatct cttgcagatc tagtcagaac attaaacata gtgatggaaa cacctattta 120
gaatggtacc tgcagaaacc aggccagtct ccaaagctcc tgatctacaa agtttccaac 180
cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc 240
aagatcagta gagtggaggc tgaggatctg ggagtttatt tctgctttca aggttcacat 300
gttcctctca cgttcggtgc tgggaccaag ctggagctga aacgtacg              348

<210> 53
<211> 383
<212> DNA
<213> Mus Musculus

<400> 53
ctcgaggagg tgcagctgca gcagtctggg cctgaactgg tggggcctgg ggaatcagtg 60
aagatttcct gcaagggttc cggctacgca ttcactgatt acggtatgca ctgggtgaaa 120
cagagtcatg caaagaggct cgagtggatt ggagttatca ctatttatga tggtcataca 180
aactacaacc agaactttaa gggcaaggcc gcattgactg tagacaaatc ctccaacaca 240
gcctatctgg aacttgccag aatgacttct gaggattctg ccatctatta ctgtgcaagg 300
ggagattacg acctcttctg gtatttggat gtctggggcg caggaacctc agtcaccgtc 360
tcctcggcct ccaccaaggg ccc                                         383

<210> 54
<211> 348
<212> DNA
<213> Mus Musculus

<400> 54
tctagagaca ttgtgatgac ccaaactcca ctctccctga ctgtcagtct tggagatcaa 60
gcctccatct cttgcagatc tagtcagaac attaaacata gtgatggaaa cacctattta 120
gaatggtacc tgcagaaacc aggccagtct ccaaagctcc tgatctacaa agtttccaac 180
cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc 240
aagatcagta gagtggaggc tgaggatctg ggagtttatt tctgctttca aggttcacat 300
gttcctctca cgttcggtgc tgggaccaag ctggagctga aacgtacg              348

<210> 55
<211> 383
<212> DNA
<213> Mus Musculus

<400> 55
ctcgaggatg tgcagcttca ggagtctggg cctgaactgg tggggcctgg ggaatcagtg 60
aagatttcct gcaagggttc cggctacaca ttcactgatt acggtatgca ctgggtgaaa 120
cagagtcatg caaagaggct cgagtggatt ggagttatca ctatttatga tggtcataca 180
aactacaacc agaactttaa gggcaaggcc gcattgactg tagacaaatc ctccaacaca 240
gcctatccgg aacttgccag aatgacttct gaggattctg ccatctatta ctgtgcaagg 300
ggagattacg acctcttctg gtatttggat gtctggggcg cagggaccac ggtcaccgtt 360
tcctcggcct ccaccaaggg ccc                                         383

<210> 56
<211> 348
<212> DNA
<213> Mus Musculus

<400> 56
tctagagatg ttgtgatgac ccaaactcca ctctccctga ctgtcagtct tggagatcaa 60
gcctccatct cttgcagatc tagtcagaac attaaacata gtgatggaaa cacctattta 120
gaatggtacc tgcagaaacc aggccagtct ccaaagctcc tgatctacaa agtttccaac 180
cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc 240
aagatcagta gagtggaggc tgaggatctg ggagtttatt tctgctttca aggttcacat 300
gttcctctca cgttcggtgc tgggaccaag ctggagctga aacgtacg              348

<210> 57
<211> 363
<212> DNA
<213> Mus Musculus

<400> 57
ctcgagcagg tccaactaca gcaacctggg tctgtgctgg tgaggcctgg agcttcagtg 60
aagctgtcct gcaaggcttc tggctacacc ttcaccaact cctggatact ctgggcgaag 120
cggaggcctg gacaaggcct tgagtggatt ggagagattc atcctaatag tggtaatact 180
aactataatg agaagttcaa gggccaggcc acactgactg tagacacatc ctccaccaca 240
gcctacgtgg atctcagcag gctgacatct gaggactctg cggtctatta ctgtgcaaga 300
tatgagggac actggggcca agggactctg gtcactgtct ctgcggcctc caccaaaggg 360
ccc                                                               363

<210> 58
<211> 348
<212> DNA
<213> Mus Musculus

<400> 58
tctagagatg ttgtgatgac ccagactcca ctcactttgt cggttaccat tggacaacca 60
gcctccatct cttgtaagtc aagtcagagc ctcttagata gtgatggaaa gacatatttg 120
aattggttgt tacagaggtc aggccagtct ccaaagcgcc taatctatct ggtgtctaaa 180
ctggactctg gagtccctga caggttcact ggcagtggat cagggacaga tttcacactg 240
aaaatcagca gagtggaggc tgaggatttg ggagtttatt attgctggca aggtacacat 300
tttcctcaga cgttcggtgg aggcaccaag ctggaaatca aacgtacg              348

<210> 59
<211> 382
<212> DNA
<213> Mus Musculus

<400> 59
ctcgaggagg tgaagctgat ggagtctgga cctgaactgg ttaagcctgg ggcttcagtg 60
aagatgtcct gcaaggcttc tggatacaca ttcactagct atgttatgca ctgggtgaag 120
cagaagcctg ggcagggcct tgagtggctt ggatatatta acccttacaa tgatggtact 180
aagtacaatg agaggttcaa aggcaaggcc acactgactt cagacaaatc ctccagcaca 240
gcctacatgg agctcatcag cctgacctct gaggactctg cggtctatta ctgtgcaaga 300
gaggcctcct atggtaaccc ctttgcttac tggggccaag ggactctggt cactgtctct 360
gcggcctcca ccccaagggc cc                                          382

<210> 60
<211> 333
<212> DNA
<213> Mus Musculus

<400> 60
tctagagaca ttcagatgat gcagtctcca gcctccctat ctgcatctgt gggagaaact 60
gtcaccatca catgtcgaac aagtgagaat atttacagtt atttagcatg gtttcagcag 120
aaacagggaa attctcctca gctcctggtc tataatacaa aaaccttagc ggaaggtgtg 180
ccatcaaggt tcagtggcag tggatcaggc acacagtttt ctctgaagat caacagcctg 240
cagcctgaag attttgggaa ttattactgt caacatcatt atgatactcc gtggacgttc 300
ggtggaggca ccaagctgga aatcaaacgt acg                              333

<210> 61
<211> 380
<212> DNA
<213> Mus Musculus

<400> 61
ctcgaggagg ttcagcttca gcagtctgga cctgaactgg ttaagcctgg ggcttcagtg 60
aagatgtcct gcaaggcttc tggatacaca ttcactagct atgttatgca ctgggtgaag 120
cagaagcctg ggcagggcct tgagtggctt ggatatatta acccttacaa tgatggtact 180
aagtacaatg agaagttcaa aggcatggcc acactgactt cagacaaatc ctccagcaca 240
gcctacatgg agctcatcag cctgacctct gaggactctg cggtctatta ctgtgcaaga 300
gaggcctcct atggtaaccc ctttgcttac tggggccaag ggactctggt cactgtctct 360
gcggcctcca ccaagggccc                                             380

<210> 62
<211> 333
<212> DNA
<213> Mus Musculus

<400> 62
tctagagaca ttgtgatgac ccagtctcca gcctccctat ctgcatctgt gggagaaact 60
gtcaccatca catgtcgaac aagtgagaat atttacagtt atttagcatg gtttcagcag 120
aaacagggaa attctcctca gctcctggtc tataatacaa aaaccttagc ggaaggtgtg 180
ccatcaaggt tcagtggcag tggatcaggc acacagtttt ctctgaagat caacagcctg 240
cagcctgaag attttgggaa ttattactgt caacatcatt atgatactcc gtggacgttc 300
ggtggaggca ccaagctgga aatcaaacgt acg                              333

<210> 63
<211> 383
<212> DNA
<213> Mus Musculus

<400> 63
ctcgaggagg tgcagcttca gcagtctgga cctgaactgg ttaagcctgg ggcttcagtg 60
aagatgtcct gcaaggcttc tggatacaca ttcactagct atgttatgca ctgggtgaag 120
cagaagcctg ggcagggcct tgagtggctt ggatatatta acccttacaa tgatggtact 180
aagtacaatg agaagttcaa aggcaaggcc acactgactt cagacaaatc ctccagcaca 240
gcctacatgg agctcatcag cctgacctct gaggactctg cggtctatta ctgtgcaaga 300
gaggcctcct atggtaaccc ctttgcttac tggggccaag ggactctggt cactgtctct 360
gcggcctccc cacccaaggg ccc                                         383

<210> 64
<211> 333
<212> DNA
<213> Mus Musculus

<400> 64
tctagagaca ttgtgatgac ccagtctcca gcctccctat ctgcatctgt gggagaaact 60
gtcaccatca catgtcgaac aagtgagaat atttacagtt atttagcatg gtttcagcag 120
aaacagggaa attctcctca gctcctggtc tataatacaa aaaccttagc ggaaggtgtg 180
ccatcaaggt tcagtggcag tggatcaggc acacagtttt ctctgaagat caacagcctg 240
cagcctgaag attttgggaa ttattactgt caacatcatt atgatactcc gtggacgttc 300
ggtggaggca ccaagctgga aataaaacgt acg                              333

<210> 65
<211> 383
<212> DNA
<213> Mus Musculus

<400> 65
ctcgaggagg tgcagctgca gcagtctgga gctgagctgg tgaagcctgg ggcttcagtg 60
aagatatcct gcaaggcttc tggttactca ttcactggct actacatgaa ctgggtgaag 120
cagagccatg gaaagagcct tgagtggatt ggaaatatta atccttacta tggcggtagt 180
aactacaatc agaagttcaa ggccagggcc acattgactg tagacaaatc ttccagcaca 240
gcctacatgc agctcaacag cctgacatcg gaggactctg cagtctatta ctgtgcaaga 300
aaaggtgacc tttactattc tatggactac tggggtcaag gaacctcagt caccgtctcc 360
tcggccctcc cacccaaggg ccc                                         383

<210> 66
<211> 348
<212> DNA
<213> Mus Musculus

<400> 66
tctagagaca ttgtgatgac ccaaactcct ctctccctgc ctgtcagtct tggagatcag 60
gcctccattt cttgcagatc tagtcagagc attgtacata gtaatggaaa cacctattta 120
gaatggtacc tacagaaacc aggccagtcc ccaaagctcc tcatctacaa agtttccaac 180
cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc 240
aagatcagca gagtggaggc tgaggatctg ggaatttatt actgctttca aggttcacat 300
gttcctccga cgttcggtgg aggcaccaag ctggagctga aacgtacg              348

<210> 67
<211> 380
<212> DNA
<213> Mus Musculus

<400> 67
ctcgaggatg tgaagcttca ggagtcggga cctggcctgg tgaaaccttc tcagtctctg 60
tccctcacct gcactgtcac tggctactca atcaccagtg attatgcctg gaactggatc 120
cggcagtttc caggaaacaa actggagtgg atgggctaca taaactacag tggcagcact 180
aactataacc catctctcaa aagtcgaatc tctatcactc gagacacatc caagaaccag 240
ttcttcctga agctgaattc tgtgacctct gaggacacag ccacatatta ctgtgcaagg 300
gatgattacg acgggtacta ctttgactac tggggccaag gcaccacggt caccgtttcc 360
tcggcctcca ccaagggccc                                             380

<210> 68
<211> 342
<212> DNA
<213> Mus Musculus

<400> 68
tctagagaca ttgtgttaac acagtctcct gcttccttag ctgtatctct ggggcagagg 60
gccaccatct catacagggc cagcaaaagt gtcagtacat ctggctatag ttatatgcac 120
tggaaccaac agaaaccagg acagccaccc agactcctca tctatcttgt atccaaccta 180
gaatctgggg tccctgccag gttcagtggc agtgggtctg ggacagactt caccctcaac 240
atccatcctg tggaggagga ggatgctgca acccattact gtcagcacat tagggagctt 300
acacgttcgg aggggggacc aagctggaaa atcaaacgta cg                    342

<210> 69
<211> 371
<212> DNA
<213> Mus Musculus

<400> 69
ctcgagcagg tccaactgca gcagcctggg tctgagctgg tgaggcctgg agcttcagtg 60
aagctgtcct gcaaggcttc tggctacaca ttcaccatct tctggatcca ctgggtgaag 120
cagaggcctg gacaaggcct tgagtggatt ggaaatattt atcctggtag tggtggaact 180
aactacgatg agaaattcaa gagcaaggcc acactgactg tagacacatt ttccagcaca 240
gcctacatgc agctcagtag cctgacatct gaggactctg cggtctatta ctgtacaaga 300
tgggggactg ggaaggacta ctggggccaa ggcaccactc tcacagtctc ctcggcctcc 360
accaagggcc c                                                      371

<210> 70
<211> 336
<212> DNA
<213> Mus Musculus

<400> 70
tctagagaca ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag 60
gtcaccatga cctgcagggc caggtcaagt gtaagttcca gttacttgca ctggtaccag 120
cagaagccag gatcttcccc caaactctgg atttatagca catccaatct ggctttaggg 180
gtcccagctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagtagt 240
gtggaggctg aggatgctgc cacttattac tgccagcagt atgatagttc cccattcacg 300
ttcggcacgg ggacaaagtt ggaaataaaa cgtacg                           336

<210> 71
<211> 383
<212> DNA
<213> Mus Musculus

<220> 
<221> misc_feature   
<222> 21
<223> n = A,T,C or G

<400> 71
ctcgagcagg ttcagctgca ncaatctggc cctgggaaat tgcagccctc ccagaccctc 60
agtctgactt gttctttttc tgggttttca ctgagcactt atggtatggg tgtaggttgg 120
attcgtcagc ctttagggaa gggtctggag tggctggcca acatttggtg gaatgatgat 180
aagtactata attcagccct gaagagccgg ctcacaatct ccaaggatac ctccaacaac 240
caggttttcc tcaagatctc cagtgtggac actgcagatg ctgccacata ctactgtgtt 300
caaatagcta acccctattg gtacttcgat gtctggggcg cagggacctc agtcaccgtc 360
tcctcggcct ccaccaaggg ccc                                         383

<210> 72
<211> 342
<212> DNA
<213> Mus Musculus

<400> 72
tctagagata ttcagatgac tcagtctcct gcttccttag ctgtatctct ggggcagagg 60
gccaccatct catacagggc cagcaaaagt gtcagtacat ctggctatag ttatatgcac 120
tggaaccaac agaaaccagg acagccaccc agactcctca tctatcttgt atccaaccta 180
gaatctgggg tccctgccag gttcagtggc agtgggtctg ggacagactt caccctcaac 240
atccatcctg tggaggagga ggatgctgca acctattact gtcagcacat tagggagctt 300
acacgttcgg aggggggacc aagctggaaa tcaaaacgta cg                    342

<210> 73
<211> 380
<212> DNA
<213> Mus Musculus

<400> 73
ctcgaggagg tgcagctgca gcagtctgga cctgagctgg tgaagcctgg ggcttcagtg 60
aagatatcct gcaaggcttc tggttactca ttcactggct accacataca ctggatgaag 120
caaagccatg tagagagcct tgagtggatt ggacgtatta atccttacag tggtgttact 180
gactacaacc agaatttcaa ggacaaggcc aacttgactg tagatcagtc ctccagcaca 240
gcctacatgg aactccacag cctgacatct gaggactctg cattctatta ctgtgcaagg 300
acggattact acggcccctg gtttgcttac tggggccaag ggactctggt cactgtctct 360
gcggcctcca ccaagggccc                                             380

<210> 74
<211> 348
<212> DNA
<213> Mus Musculus

<400> 74
tctagagata ttcagatgac gcagtctcca ctctccctgc ctgtcagtct tggagatcaa 60
gcctccatct cttgcagatc tagtccgagc cttgtacaca gtaatggaaa cacctattta 120
cattggtacc tgcagaagcc aggccagtct ccaaagctcc tgatctacac agtttccaac 180
cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc 240
aagatcaaca gagtggaggc tgaggatctg ggagtttatt tctgctctca aactacacat 300
gttccgtgga cgttcggtgg aggcaccaag ctggaaataa aacgtacg              348

<210> 75
<211> 120
<212> PRT
<213> Mus Musculus

<400> 75
Glu Val Gln Leu Gln Gln Ser Gly Pro Lys Leu Val Gly Pro Gly Glu
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Gly Met His Trp Val Lys Gln Ser His Ala Lys Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Thr Ile Tyr Asp Gly His Thr Asn Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Glu Leu Ala Arg Met Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Tyr Asp Leu Phe Trp Tyr Leu Asp Val Trp Gly Ala
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser
        115                 120 


<210> 76
<211> 114
<212> PRT
<213> Mus Musculus

<400> 76
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Thr Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Lys His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         
Arg Thr
        


<210> 77
<211> 120
<212> PRT
<213> Mus Musculus

<400> 77
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gly Pro Gly Glu
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ala Phe Thr Asp Tyr
            20                  25                  30          
Gly Met His Trp Val Lys Gln Ser His Ala Lys Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Thr Ile Tyr Asp Gly His Thr Asn Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Glu Leu Ala Arg Met Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Tyr Asp Leu Phe Trp Tyr Leu Asp Val Trp Gly Ala
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 78
<211> 114
<212> PRT
<213> Mus Musculus

<400> 78
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Thr Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Lys His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         
Arg Thr
        


<210> 79
<211> 120
<212> PRT
<213> Mus Musculus

<400> 79
Asp Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Gly Pro Gly Glu
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Gly Met His Trp Val Lys Gln Ser His Ala Lys Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Thr Ile Tyr Asp Gly His Thr Asn Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Pro Glu Leu Ala Arg Met Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Tyr Asp Leu Phe Trp Tyr Leu Asp Val Trp Gly Ala
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser
        115                 120 


<210> 80
<211> 114
<212> PRT
<213> Mus Musculus

<400> 80
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Thr Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Lys His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         
Arg Thr
        


<210> 81
<211> 113
<212> PRT
<213> Mus Musculus

<400> 81
Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
            20                  25                  30          
Trp Ile Leu Trp Ala Lys Arg Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Gln Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr
65                  70                  75                  80  
Val Asp Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Glu Gly His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ala
    


<210> 82
<211> 114
<212> PRT
<213> Mus Musculus

<400> 82
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Ser Gly Gln Ser
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr
        


<210> 83
<211> 119
<212> PRT
<213> Mus Musculus

<400> 83
Glu Val Lys Leu Met Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Ala Ser Tyr Gly Asn Pro Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 84
<211> 109
<212> PRT
<213> Mus Musculus

<400> 84
Asp Ile Gln Met Met Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 85
<211> 119
<212> PRT
<213> Mus Musculus

<400> 85
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Met Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Ala Ser Tyr Gly Asn Pro Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 86
<211> 109
<212> PRT
<213> Mus Musculus

<400> 86
Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 87
<211> 119
<212> PRT
<213> Mus Musculus

<400> 87
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Ala Ser Tyr Gly Asn Pro Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 88
<211> 107
<212> PRT
<213> Mus Musculus

<400> 88
Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 89
<211> 119
<212> PRT
<213> Mus Musculus

<400> 89
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asn Pro Tyr Tyr Gly Gly Ser Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Ala Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Asp Leu Tyr Tyr Ser Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser
        115                 


<210> 90
<211> 114
<212> PRT
<213> Mus Musculus

<400> 90
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         
Arg Thr
        


<210> 91
<211> 119
<212> PRT
<213> Mus Musculus

<400> 91
Asp Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Tyr Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 92
<211> 112
<212> PRT
<213> Mus Musculus

<400> 92
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr His Tyr Cys Gln His Ile Arg
                85                  90                  95      
Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Ile Lys Arg Thr
            100                 105                 110         


<210> 93
<211> 116
<212> PRT
<213> Mus Musculus

<400> 93
Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Phe
            20                  25                  30          
Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Phe Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Trp Gly Thr Gly Lys Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 94
<211> 110
<212> PRT
<213> Mus Musculus

<400> 94
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Leu Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro
                85                  90                  95      
Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 110 


<210> 95
<211> 120
<212> PRT
<213> Mus Musculus

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<400> 95
Gln Val Gln Leu Xaa Gln Ser Gly Pro Gly Lys Leu Gln Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Leu Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asn Asp Asp Lys Tyr Tyr Asn Ser Ala
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val
65                  70                  75                  80  
Phe Leu Lys Ile Ser Ser Val Asp Thr Ala Asp Ala Ala Thr Tyr Tyr
                85                  90                  95      
Cys Val Gln Ile Ala Asn Pro Tyr Trp Tyr Phe Asp Val Trp Gly Ala
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 96
<211> 112
<212> PRT
<213> Mus Musculus

<400> 96
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg
                85                  90                  95      
Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Ser Lys Arg Thr
            100                 105                 110         


<210> 97
<211> 119
<212> PRT
<213> Mus Musculus

<400> 97
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
His Ile His Trp Met Lys Gln Ser His Val Glu Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asn Pro Tyr Ser Gly Val Thr Asp Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Asp Lys Ala Asn Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys
                85                  90                  95      
Ala Arg Thr Asp Tyr Tyr Gly Pro Trp Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 98
<211> 114
<212> PRT
<213> Mus Musculus

<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Pro Ser Leu Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Thr
        

