                               SEQUENCE LISTING

<110> ARMAGEN TECHNOLOGIES, INC.
 
<120> METHODS AND COMPOSITIONS FOR INCREASING IDURONATE 2-SULFATASE 
      ACTIVITY IN THE CNS

<130> 28570-710.601

<140> PCT/US2010/052113
<141> 2010-10-08

<150> 61/256,049
<151> 2009-10-29

<150> 61/250,378
<151> 2009-10-09

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gly Tyr Thr Phe Thr Asn Tyr Asp Ile His 
1               5                   10  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Glu Trp Ala Tyr 
1               


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Arg Ala Ser Gln Asp Ile Gly Gly Asn Leu Tyr 
1               5                   10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Leu Gln Tyr Ser Ser Ser Pro Trp Thr 
1               5                   


<210> 7
<211> 462
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser 
    450                 455                 460         


<210> 8
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Gly Asn Leu Tyr Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ser 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 9
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210> 10
<211> 989
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
465                 470                 475                 480 


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
                485                 490                 495     


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
            500                 505                 510         


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
        515                 520                 525             


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
    530                 535                 540                 


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
545                 550                 555                 560 


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
                565                 570                 575     


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
            580                 585                 590         


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
        595                 600                 605             


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
    610                 615                 620                 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
625                 630                 635                 640 


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
                645                 650                 655     


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
            660                 665                 670         


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
        675                 680                 685             


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
    690                 695                 700                 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
705                 710                 715                 720 


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
                725                 730                 735     


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
            740                 745                 750         


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
        755                 760                 765             


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
    770                 775                 780                 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
785                 790                 795                 800 


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
                805                 810                 815     


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
            820                 825                 830         


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
        835                 840                 845             


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
    850                 855                 860                 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
865                 870                 875                 880 


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
                885                 890                 895     


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
            900                 905                 910         


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
        915                 920                 925             


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
    930                 935                 940                 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
945                 950                 955                 960 


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
                965                 970                 975     


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
            980                 985                 


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
cctccgaaac gcaggccaac tcg                                               23


<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
tcaaggcatc aacaactgga aaagatc                                           27


<210> 13
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gccgccacca tggagacccc cgcccagctg ctgttcctgt tgctgctttg gcttccagat       60

actaccggcg acatccagat gacccagtct ccatcctcct tatctgcctc tctgggagaa      120

agagtcagtc tcacttgtcg ggcaagtcag gacattggtg gtaacttata ctggcttcag      180

cagggaccag atggaactat taaacgcctg atctacgcca catccagttt agattctggt      240

gtccccaaaa ggttcagtgg cagtaggtct gggtcagatt attctctcac catcagcagc      300

cttgagtctg aagattttgt agactattac tgtctacagt attctagttc tccgtggacg      360

ttcggtggag gcacaaagct ggaaataaaa cgaactgtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


<210> 14
<211> 2979
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc ctccgaaacg caggccaact cgaccacaga tgctctgaac     1440

gttcttctca tcatcgtgga tgacctgcgc ccctccctgg gctgttatgg ggataagctg     1500

gtgaggtccc caaatattga ccaactggca tcccacagcc tcctcttcca gaatgccttt     1560

gcgcagcaag cagtgtgcgc cccgagccgc gtttctttcc tcactggcag gagacctgac     1620

accacccgcc tgtacgactt caactcctac tggagggtgc acgctggaaa cttctccacc     1680

atcccccagt acttcaagga gaatggctat gtgaccatgt cggtgggaaa agtctttcac     1740

cctgggatat cttctaacca tactgatgat tctccgtata gctggtcttt tccaccttat     1800

catccttcct ctgagaagta tgaaaacact aagacatgtc gagggccaga tggagaactc     1860

catgccaacc tgctttgccc tgtggatgtg ctggatgttc ccgagggcac cttgcctgac     1920

aaacagagca ctgagcaagc catacagttg ttggaaaaga tgaaaacgtc agccagtcct     1980

ttcttcctgg ccgttgggta tcataagcca cacatcccct tcagataccc caaggaattt     2040

cagaagttgt atcccttgga gaacatcacc ctggcccccg atcccgaggt ccctgatggc     2100

ctaccccctg tggcctacaa cccctggatg gacatcaggc aacgggaaga cgtccaagcc     2160

ttaaacatca gtgtgccgta tggtccaatt cctgtggact ttcagcggaa aatccgccag     2220

agctactttg cctctgtgtc atatttggat acacaggtcg gccgcctctt gagtgctttg     2280

gacgatcttc agctggccaa cagcaccatc attgcattta cctcggatca tgggtgggct     2340

ctaggtgaac atggagaatg ggccaaatac agcaattttg atgttgctac ccatgttccc     2400

ctgatattct atgttcctgg aaggacggct tcacttccgg aggcaggcga gaagcttttc     2460

ccttacctcg acccttttga ttccgcctca cagttgatgg agccaggcag gcaatccatg     2520

gaccttgtgg aacttgtgtc tctttttccc acgctggctg gacttgcagg actgcaggtt     2580

ccacctcgct gccccgttcc ttcatttcac gttgagctgt gcagagaagg caagaacctt     2640

ctgaagcatt ttcgattccg tgacttggaa gaggatccgt acctccctgg taatccccgt     2700

gaactgattg cctatagcca gtatccccgg ccttcagaca tccctcagtg gaattctgac     2760

aagccgagtt taaaagatat aaagatcatg ggctattcca tacgcaccat agactatagg     2820

tatactgtgt gggttggctt caatcctgat gaatttctag ctaacttttc tgacatccat     2880

gcaggggaac tgtattttgt ggattctgac ccattgcagg atcacaatat gtataatgat     2940

tcccaaggtg gagatctttt ccagttgttg atgccttga                            2979


<210> 15
<211> 573
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gccgccacca tggttcgacc attgaactgc atcgtcgccg tgtcccaaaa tatggggatt       60

ggcaagaacg gagacctacc ctggcctccg ctcaggaacg agttcaagta cttccaaaga      120

atgaccacaa cctcttcagt ggaaggtaaa cagaatctgg tgattatggg taggaaaacc      180

tggttctcca ttcctgagaa gaatcgacct ttaaaggaca gaattaatat agttctcagt      240

agagaactca aagaaccacc acgaggagct cattttcttg ccaaaagttt ggatgatgcc      300

ttaagactta ttgaacaacc ggaattggca agtaaagtag acatggtttg gatagtcgga      360

ggcagttctg tttaccagga agccatgaat caaccaggcc acctcagact ctttgtgaca      420

aggatcatgc aggaatttga aagtgacacg tttttcccag aaattgattt ggggaaatat      480

aaacttctcc cagaataccc aggcgtcctc tctgaggtcc aggaggaaaa aggcatcaag      540

tataagtttg aagtctacga gaagaaagac taa                                   573


<210> 16
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Gly Asn Leu Tyr Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ser 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 17
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ccacagatgc tctgaacgtt cttc                                              24


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


