                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  ORAL DELIVERY OF THERAPEUTICALLY EFFECTIVE LNA OLIGONUCLEOTIDES

<130>  1098 WO

<150>  US 61/253090
<151>  2009-10-20

<150>  US 61/321892
<151>  2010-04-08

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Resdiues 1,3, 4, 6, 7, 8, 10, 12, 14 & 15 are LNA units, remainder are DNA units. 
       Internucleoside linkages are preferably phosphorothioate.  LNA 
       cytosines are all preferably methylated/5-methyl cytosine.

<400>  1
tcagtctgat aagct                                                        15


<210>  2
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Resdiues 1, 3, 5, 6, 7, 10, 11, 12, 14 & 15 are LNA units, remainder are DNA units. 
       Internucleoside linkages are preferably phosphorothioate.  LNA 
       cytosines are all preferably methylated/5-methyl cytosine.

<400>  2
tcacaattag catta                                                        15


<210>  3
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Resdiues 1,3, 6, 7, 10, 12, 14 & 15 are LNA units, remainder are DNA units. 
       Internucleoside linkages are preferably phosphorothioate.  LNA 
       cytosines are all preferably methylated/5-methyl cytosine.

<400>  3
ccattgtcac actcc                                                        15


<210>  4
<211>  10
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  4
gtcacactcc                                                              10


<210>  5
<211>  11
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  5
tgtcacactc c                                                            11


<210>  6
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  6
attgtcacac tcc                                                          13


<210>  7
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  7
cattgtcaca ctcc                                                         14


<210>  8
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  8
ccattgtcac actcc                                                        15


<210>  9
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  9
accattgtca cactcc                                                       16


<210>  10
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  10
caccattgtc acactcc                                                      17


<210>  11
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  11
acaccattgt cacactcc                                                     18


<210>  12
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  12
aacaccattg tcacactcc                                                    19


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  13
aaacaccatt gtcacactcc                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  14
caaacaccat tgtcacactc c                                                 21


<210>  15
<211>  10
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  15
tgtcacactc                                                              10


<210>  16
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  16
attgtcacac tc                                                           12


<210>  17
<211>  11
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  17
attgtcacac t                                                            11


<210>  18
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  18
cattgtcaca ctc                                                          13


<210>  19
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  19
cattgtcaca ct                                                           12


<210>  20
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  20
ccattgtcac actc                                                         14


<210>  21
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  21
ccattgtcac act                                                          13


<210>  22
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  22
accattgtca cactc                                                        15


<210>  23
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  23
accattgtca cact                                                         14


<210>  24
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  24
caccattgtc acactc                                                       16


<210>  25
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  25
caccattgtc acact                                                        15


<210>  26
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  26
acaccattgt cacactc                                                      17


<210>  27
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  27
acaccattgt cacact                                                       16


<210>  28
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  28
aacaccattg tcacactc                                                     18


<210>  29
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  29
aacaccattg tcacact                                                      17


<210>  30
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  30
aaacaccatt gtcacactc                                                    19


<210>  31
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  31
aaacaccatt gtcacact                                                     18


<210>  32
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  32
caaacaccat tgtcacactc                                                   20


<210>  33
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  33
caaacaccat tgtcacact                                                    19


<210>  34
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer base sequence

<400>  34
caaacaccat tgtcacactc ca                                                22


<210>  35
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Residues 1, 2, 11, 12 & 13 are beta-D-oxy LNA units, remaining 
       residues are DNA units. Internucleoside linkages are 
       phosphorothioate.  LNA cytosines are y 5'methyl 
       cytosine.

<400>  35
gtctgtggaa gcg                                                          13


<210>  36
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  residues 1, 2, 11, 12, 13 are beta-D-oxy-LNA units, LNA C are 5'methyl 
       cytosine, remaining residues are DNA, fully phosphorothioate.

<400>  36
gcattggtat tca                                                          13


<210>  37
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  residues 1, 3, 6, 7, 10, 12, 14, & 15 are beta-D-oxy-LNA units, LNA Cs 
       are 5'methyl cytosine, remaining residues are DNA, fully 
       phosphorothioate.

<400>  37
ccattgtcac actcc                                                        15


<210>  38
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  residues 1, 2, 11 & 12 are beta-D-oxy-LNA units, LNA Cs are 5'methyl 
       cytosine, remaining residues are DNA, fully phosphorothioate.

<400>  38
gttgacactg tc                                                           12


