
                                SEQUENCE LISTING

<110> Buxbaum, Joseph
      Sakurai, Takeshi
      Ozlem, Bozdagi

<120> Methods Of Treating Psychiatric Or
  Neurological Disorders With Mglur Antagonists
  
<130> 27527-0065WO1

<150> 61/255,340          
<151> 2009-10-27  

<160> 34

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4446
<212> DNA
<213> Homo sapiens

<400> 1
gagtgtttcc tggcgcattc ccggccagcc cgagtgactc actcggccaa ggaaactccc 60
agggcccgcc caggaccccc aagccgccgc ggacgcagcc caggatggcg gcccaggtga 120
ctctggagga cgcgctgtcc aacgtggacc tcctggagga gctgcccctg cccgaccagc 180
agccctgcat cgagcccccg ccatcctcgc tgctctacca gccaaatttc aacactaact 240
ttgaagacag aaatgcattt gttactggca tcgcaagata cattgaacaa gccaccgtcc 300
actctagcat gaacgagatg ctggaggagg gccaagaata tgctgtcatg ctgtacacct 360
ggaggagctg ctcccgggcc atcccacagg tgaaatgtaa cgagcagcct aacagagtgg 420
aaatctacga gaaaaccgtg gaggttctgg agcctgaggt cacaaaactg atgaatttca 480
tgtacttcca gagaaatgcc attgagcgtt tctgcgggga agtgaggcgc ctgtgccatg 540
ccgagaggag gaaggacttc gtgtcagaag cctacctgat cacactgggc aaattcatca 600
acatgttcgc tgtgctggac gagctgaaga acatgaagtg cagtgtgaag aacgaccact 660
cagcgtacaa gagggccgct cagtttttac gtaaaatggc agatccacag tccatccagg 720
aatcgcagaa tctgtccatg ttcctggcca atcataacaa gatcacacag tctctgcagc 780
agcagctcga agtgatttct ggctacgaag agctcctggc agatattgtg aatctgtgtg 840
tggattacta cgagaacagg atgtatttga cgcccagtga gaaacacatg cttctcaaag 900
tcatgggatt tggtctgtac ctgatggatg ggagtgtcag taacatctat aagttggatg 960
ccaagaaaag aataaactta tccaaaatcg acaagtactt caagcaactc caggtggttc 1020
cgctatttgg ggacatgcaa atagaactgg caagatatat caagaccagc gcccactacg 1080
aggaaaataa atctcgatgg acgtgcacat cctccggcag cagccctcag tacaacatct 1140
gcgagcagat gatccagatc cgcgaggacc acatgcgctt catttcggag ctggcgcgct 1200
acagcaacag cgaggtggtc acgggctcgg gccgccagga ggcccagaag acggacgcgg 1260
agtaccgcaa gctcttcgac ctggcgctgc agggcctgca gctgttgtcg cagtggagcg 1320
cgcacgtgat ggaagtgtat tcctggaagc ttgtgcaccc caccgacaag tactccaaca 1380
aggactgccc cgacagcgct gaagagtacg agcgtgccac gcgctacaac tacaccagcg 1440
aggagaagtt tgccctagtg gaggtgatcg ccatgatcaa aggcctgcag gtgctgatgg 1500
gcaggatgga gagcgtgttc aaccacgcca tccggcacac cgtctatgcc gcactgcagg 1560
acttctccca ggtgaccctt agggagccgc tgcggcaggc catcaagaag aagaagaacg 1620
tcatccagag tgtcctgcag gccatcagga agaccgtgtg tgactgggag acggggcatg 1680
agcccttcaa tgacccagcc ttgcggggcg agaaggaccc caagagcggc ttcgacataa 1740
aagtaccacg ccgcgccgtg ggaccctcca gcactcagct ttacatggtg agaaccatgc 1800
tagagtccct cattgcagac aaaagtggtt ccaagaaaac cttgagaagt agccttgagg 1860
ggcccaccat attggacata gaaaaatttc atcgagagtc attcttctac actcacttga 1920
taaatttcag tgaaacgctg cagcagtgct gtgacctttc gcagctgtgg ttccgagagt 1980
tcttcctgga gctgaccatg ggcaggagga tccagttccc cattgagatg tcgatgccct 2040
ggatcctgac ggaccacatc ctggagacca aggaggcatc gatgatggag tacgtgctct 2100
actccctgga cctgtacaat gacagcgccc actacgcgct caccaggttc aacaagcagt 2160
tcctgtacga cgaaattgag gccgaggtga atctatgttt tgaccaattt gtttacaagc 2220
tagcagacca gatatttgcc tattataagg ttatggcagg aagtttgctt cttgataaac 2280
ggttacgatc agaatgcaag aatcagggag ccacgatcca cctcccgccg tctaaccgct 2340
acgagacgct gctgaagcag aggcatgtgc agctcctcgg cagatcaata gacctcaatc 2400
gtctgatcac ccagcgcgtc tcagcagcca tgtataagtc cctagaactg gcgattggac 2460
gatttgaaag tgaagatttg acctccatag ttgagctgga tggcctgttg gaaatcaacc 2520
gcatgaccca caagctgctg agccggtacc tgacgctgga cggcttcgac gccatgttcc 2580
gggaggccaa ccacaacgtg tcagcgccct acgggaggat caccctgcac gtcttctggg 2640
agctcaacta tgacttcctg cccaactact gctacaacgg ctctaccaac cggtttgttc 2700
ggacagtgtt accattttct caggaatttc aaagagataa gcagcctaat gcacagcctc 2760
agtatctgca tggatccaag gctttgaact tggcctactc cagcatttac ggcagctacc 2820
ggaacttcgt gggacctcca cactttcaag tcatctgccg gcttctcggc taccagggta 2880
tcgccgtggt catggaggag ctgctgaagg tcgtcaagag cctgctgcaa ggcacaatcc 2940
tgcagtacgt gaagacgctg atggaggtga tgcccaagat ctgccgcctg ccccggcacg 3000
agtacggctc tcctggtatc ctggagttct tccaccacca gctgaaggac atcgtggagt 3060
acgcagagct gaagacggtg tgcttccaga acctgcggga ggtggggaac gccatcctct 3120
tctgcctgct catcgagcag agcctgtctt tagaagaagt gtgtgacctg ctgcacgcgg 3180
ctcctttcca gaacatcttg ccgcgagtcc atgtgaaaga gggggagaga cttgatgcca 3240
aaatgaaaag actagaatca aagtacgccc cgctgcatct tgtcccactg attgaaagac 3300
tggggacccc tcagcaaatt gccatcgcaa gagaggggga cctgctgaca aaggagcgcc 3360
tctgctgcgg cctgtccatg tttgaggtca tcctgacacg gatccggagc tttctggatg 3420
accccatctg gcgcgggcct ctgcccagca atggggtcat gcatgtggac gagtgtgtgg 3480
agtttcacag actgtggagt gccatgcagt ttgtctactg cattcccgtg gggacacacg 3540
agttcacagt cgagcagtgc tttggtgatg ggctacactg ggctggctgt atgatcatcg 3600
tacttcttgg gcagcagcgg cgttttgctg tgctggattt ctgctaccat ctacttaaag 3660
tccagaaaca tgatggcaaa gatgagatta ttaaaaatgt gcctttgaag aagatggtgg 3720
agagaattcg caagttccag attctcaatg atgagatcat caccatcctg gataagtacc 3780
tgaagtcagg cgacggggag ggcacgccag tggagcatgt gcgctgcttc cagccgccca 3840
tccaccagtc cctcgccagc agctgagggc acgcgctgca ctccgtaact caacatggca 3900
tgcctttctc tccgtaaact atttagtgag atttttaggg actatttttc agtatctctg 3960
tacctgttaa agggggtgct tttcgatcta aaaacttaat tttataaaat tgacttattt 4020
ttctagacta aaattgtata tgcttttggt aattaggaac tcttgagaat attggctgct 4080
gattgttgcc atcacgttcc tacaaaattg tttttctatg ggatgttctg gcagctgtgt 4140
cataaaatgc tgctgggttc attcattcat tccataagaa acttaatacc agcaaatgca 4200
ttaaatccct tgccagttac cattaactgt aactatttag cttttgttta gggatctttc 4260
tgatggtctt ttatgagcaa tcttagttct aagtcattgt tcccatccct tttttgtgtg 4320
tttcagaaaa tagtgaactt gattcccctg cttccactaa atccagttgt gacaaaatct 4380
aacgtgacat cagatcgaaa ggttatagaa ataaaactaa tgagatctaa aaaaaaaaaa 4440
aaaaaa                                                            4446

<210> 2
<211> 3351
<212> DNA
<213> Homo sapiens

<400> 2
ccggtttaat ccacaccgct gcgtctgtcc tccgtcctgg ggctggtctt ctccctcatc 60
tctgccggag gcttttaatc tcttctgcca ctcttctgga aagtcaccag caatgcacgc 120
tgctggctct gcaggagggt cagggggacg gccctcggcc tgtgcgtggt gccagccacc 180
ctccctgcct ccctctgcgt gcgtcccgtg tccctgcctg gggtgtgtgt gtcgagtgac 240
taacgtctct ctcctgcctc tccctcctgt ctgtccgtgt ctagctctac ctggtgcgca 300
ccatggccga gtccttgggc tctgccgagc tgctcaggca gctcaagtct ctgggcatgg 360
agaggctctt gcatgcggtt aacacgtttc tgaggcagtc gtgcacctac ctaccccttt 420
taacctttgg tggtaagaca tcatttgttt ctcttgacgt ttatggcacg gaggcgaact 480
gctccgctac aagttgttct ttccccaaag cagcagcaac gtggccgcgt agacaggcac 540
ccggacccct cggggagctg gtgcggggcc ctcccgacca gggcgtagcg gagcagtcct 600
tctctcatgg gctttttgag tttggcataa ctaatgtacc atgtatattt tctcccccac 660
aaatgtttcc ttggataatc cagctttaca tggtgagaac catgctagag tccctcattg 720
cagacaaaag tggttccaag aaaaccttga gaagtagcct tgaggggccc accatattgg 780
acatagaaaa atttcatcga gagtcattct tctacactca cttgataaat ttcagtgaaa 840
cgctgcagca gtgctgtgac ctttcgcagc tgtggttccg agagttcttc ctggagctga 900
ccatgggcag gaggatccag ttccccattg agatgtcgat gccctggatc ctgacggacc 960
acatcctgga gaccaaggag gcatcgatga tggagtacgt gctctactcc ctggacctgt 1020
acaatgacag cgcccactac gcgctcacca ggttcaacaa gcagttcctg tacgacgaaa 1080
ttgaggccga ggtgaatcta tgttttgacc aatttgttta caagctagca gaccagatat 1140
ttgcctatta taaggttatg gcaggaagtt tgcttcttga taaacggtta cgatcagaat 1200
gcaagaatca gggagccacg atccacctcc cgccgtctaa ccgctacgag acgctgctga 1260
agcagaggca tgtgcagctc ctcggcagat caatagacct caatcgtctg atcacccagc 1320
gcgtctcagc agccatgtat aagtccctag aactggcgat tggacgattt gaaagtgaag 1380
atttgacctc catagttgag ctggatggcc tgttggaaat caaccgcatg acccacaagc 1440
tgctgagccg gtacctgacg ctggacggct tcgacgccat gttccgggag gccaaccaca 1500
acgtgtcagc gccctacggg aggatcaccc tgcacgtctt ctgggagctc aactatgact 1560
tcctgcccaa ctactgctac aacggctcta ccaaccggtt tgttcggaca gtgttaccat 1620
tttctcagga atttcaaaga gataagcagc ctaatgcaca gcctcagtat ctgcatggat 1680
ccaaggcttt gaacttggcc tactccagca tttacggcag ctaccggaac ttcgtgggac 1740
ctccacactt tcaagtcatc tgccggcttc tcggctacca gggtatcgcc gtggtcatgg 1800
aggagctgct gaaggtcgtc aagagcctgc tgcaaggcac aatcctgcag tacgtgaaga 1860
cgctgatgga ggtgatgccc aagatctgcc gcctgccccg gcacgagtac ggctctcctg 1920
gtatcctgga gttcttccac caccagctga aggacatcgt ggagtacgca gagctgaaga 1980
cggtgtgctt ccagaacctg cgggaggtgg ggaacgccat cctcttctgc ctgctcatcg 2040
agcagagcct gtctttagaa gaagtgtgtg acctgctgca cgcggctcct ttccagaaca 2100
tcttgccgcg agtccatgtg aaagaggggg agagacttga tgccaaaatg aaaagactag 2160
aatcaaagta cgccccgctg catcttgtcc cactgattga aagactgggg acccctcagc 2220
aaattgccat cgcaagagag ggggacctgc tgacaaagga gcgcctctgc tgcggcctgt 2280
ccatgtttga ggtcatcctg acacggatcc ggagctttct ggatgacccc atctggcgcg 2340
ggcctctgcc cagcaatggg gtcatgcatg tggacgagtg tgtggagttt cacagactgt 2400
ggagtgccat gcagtttgtc tactgcattc ccgtggggac acacgagttc acagtcgagc 2460
agtgctttgg tgatgggcta cactgggctg gctgtatgat catcgtactt cttgggcagc 2520
agcggcgttt tgctgtgctg gatttctgct accatctact taaagtccag aaacatgatg 2580
gcaaagatga gattattaaa aatgtgcctt tgaagaagat ggtggagaga attcgcaagt 2640
tccagattct caatgatgag atcatcacca tcctggataa gtacctgaag tcaggcgacg 2700
gggagggcac gccagtggag catgtgcgct gcttccagcc gcccatccac cagtccctcg 2760
ccagcagctg agggcacgcg ctgcactccg taactcaaca tggcatgcct ttctctccgt 2820
aaactattta gtgagatttt tagggactat ttttcagtat ctctgtacct gttaaagggg 2880
gtgcttttcg atctaaaaac ttaattttat aaaattgact tatttttcta gactaaaatt 2940
gtatatgctt ttggtaatta ggaactcttg agaatattgg ctgctgattg ttgccatcac 3000
gttcctacaa aattgttttt ctatgggatg ttctggcagc tgtgtcataa aatgctgctg 3060
ggttcattca ttcattccat aagaaactta ataccagcaa atgcattaaa tcccttgcca 3120
gttaccatta actgtaacta tttagctttt gtttagggat ctttctgatg gtcttttatg 3180
agcaatctta gttctaagtc attgttccca tccctttttt gtgtgtttca gaaaatagtg 3240
aacttgattc ccctgcttcc actaaatcca gttgtgacaa aatctaacgt gacatcagat 3300
cgaaaggtta tagaaataaa actaatgaga tctaaaaaaa aaaaaaaaaa a          3351

<210> 3
<211> 1253
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Gln Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu
 1               5                  10                  15      
Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro
            20                  25                  30          
Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Thr Asn Phe Glu Asp
        35                  40                  45              
Arg Asn Ala Phe Val Thr Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr
    50                  55                  60                  
Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala
65                  70                  75                  80  
Val Met Leu Tyr Thr Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val
                85                  90                  95      
Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Thr Val
            100                 105                 110         
Glu Val Leu Glu Pro Glu Val Thr Lys Leu Met Asn Phe Met Tyr Phe
        115                 120                 125             
Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys
    130                 135                 140                 
His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Ile Thr
145                 150                 155                 160 
Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn
                165                 170                 175     
Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala
            180                 185                 190         
Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln
        195                 200                 205             
Asn Leu Ser Met Phe Leu Ala Asn His Asn Lys Ile Thr Gln Ser Leu
    210                 215                 220                 
Gln Gln Gln Leu Glu Val Ile Ser Gly Tyr Glu Glu Leu Leu Ala Asp
225                 230                 235                 240 
Ile Val Asn Leu Cys Val Asp Tyr Tyr Glu Asn Arg Met Tyr Leu Thr
                245                 250                 255     
Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr
            260                 265                 270         
Leu Met Asp Gly Ser Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys
        275                 280                 285             
Arg Ile Asn Leu Ser Lys Ile Asp Lys Tyr Phe Lys Gln Leu Gln Val
    290                 295                 300                 
Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys
305                 310                 315                 320 
Thr Ser Ala His Tyr Glu Glu Asn Lys Ser Arg Trp Thr Cys Thr Ser
                325                 330                 335     
Ser Gly Ser Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Ile Gln Ile
            340                 345                 350         
Arg Glu Asp His Met Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn
        355                 360                 365             
Ser Glu Val Val Thr Gly Ser Gly Arg Gln Glu Ala Gln Lys Thr Asp
    370                 375                 380                 
Ala Glu Tyr Arg Lys Leu Phe Asp Leu Ala Leu Gln Gly Leu Gln Leu
385                 390                 395                 400 
Leu Ser Gln Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu
                405                 410                 415     
Val His Pro Thr Asp Lys Tyr Ser Asn Lys Asp Cys Pro Asp Ser Ala
            420                 425                 430         
Glu Glu Tyr Glu Arg Ala Thr Arg Tyr Asn Tyr Thr Ser Glu Glu Lys
        435                 440                 445             
Phe Ala Leu Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu
    450                 455                 460                 
Met Gly Arg Met Glu Ser Val Phe Asn His Ala Ile Arg His Thr Val
465                 470                 475                 480 
Tyr Ala Ala Leu Gln Asp Phe Ser Gln Val Thr Leu Arg Glu Pro Leu
                485                 490                 495     
Arg Gln Ala Ile Lys Lys Lys Lys Asn Val Ile Gln Ser Val Leu Gln
            500                 505                 510         
Ala Ile Arg Lys Thr Val Cys Asp Trp Glu Thr Gly His Glu Pro Phe
        515                 520                 525             
Asn Asp Pro Ala Leu Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp
    530                 535                 540                 
Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Thr Gln Leu Tyr
545                 550                 555                 560 
Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser
                565                 570                 575     
Lys Lys Thr Leu Arg Ser Ser Leu Glu Gly Pro Thr Ile Leu Asp Ile
            580                 585                 590         
Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Thr His Leu Ile Asn Phe
        595                 600                 605             
Ser Glu Thr Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg
    610                 615                 620                 
Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe Pro Ile
625                 630                 635                 640 
Glu Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu Thr Lys
                645                 650                 655     
Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn
            660                 665                 670         
Asp Ser Ala His Tyr Ala Leu Thr Arg Phe Asn Lys Gln Phe Leu Tyr
        675                 680                 685             
Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr
    690                 695                 700                 
Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser
705                 710                 715                 720 
Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly Ala
                725                 730                 735     
Thr Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gln
            740                 745                 750         
Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile
        755                 760                 765             
Thr Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala Ile
    770                 775                 780                 
Gly Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile Val Glu Leu Asp Gly
785                 790                 795                 800 
Leu Leu Glu Ile Asn Arg Met Thr His Lys Leu Leu Ser Arg Tyr Leu
                805                 810                 815     
Thr Leu Asp Gly Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val
            820                 825                 830         
Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu Leu Asn
        835                 840                 845             
Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe
    850                 855                 860                 
Val Arg Thr Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys Gln
865                 870                 875                 880 
Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn Leu
                885                 890                 895     
Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro
            900                 905                 910         
His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val
        915                 920                 925             
Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly Thr
    930                 935                 940                 
Ile Leu Gln Tyr Val Lys Thr Leu Met Glu Val Met Pro Lys Ile Cys
945                 950                 955                 960 
Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe
                965                 970                 975     
His His Gln Leu Lys Asp Ile Val Glu Tyr Ala Glu Leu Lys Thr Val
            980                 985                 990         
Cys Phe Gln Asn Leu Arg Glu Val Gly Asn Ala Ile Leu Phe Cys Leu
        995                 1000                1005            
Leu Ile Glu Gln Ser Leu Ser Leu Glu Glu Val Cys Asp Leu Leu His
    1010                1015                1020                
Ala Ala Pro Phe Gln Asn Ile Leu Pro Arg Val His Val Lys Glu Gly
1025                1030                1035               1040 
Glu Arg Leu Asp Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala Pro
                1045                1050                1055    
Leu His Leu Val Pro Leu Ile Glu Arg Leu Gly Thr Pro Gln Gln Ile
            1060                1065                1070        
Ala Ile Ala Arg Glu Gly Asp Leu Leu Thr Lys Glu Arg Leu Cys Cys
        1075                1080                1085            
Gly Leu Ser Met Phe Glu Val Ile Leu Thr Arg Ile Arg Ser Phe Leu
    1090                1095                1100                
Asp Asp Pro Ile Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met His
1105                1110                1115               1120 
Val Asp Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met Gln Phe
                1125                1130                1135    
Val Tyr Cys Ile Pro Val Gly Thr His Glu Phe Thr Val Glu Gln Cys
            1140                1145                1150        
Phe Gly Asp Gly Leu His Trp Ala Gly Cys Met Ile Ile Val Leu Leu
        1155                1160                1165            
Gly Gln Gln Arg Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu Leu
    1170                1175                1180                
Lys Val Gln Lys His Asp Gly Lys Asp Glu Ile Ile Lys Asn Val Pro
1185                1190                1195               1200 
Leu Lys Lys Met Val Glu Arg Ile Arg Lys Phe Gln Ile Leu Asn Asp
                1205                1210                1215    
Glu Ile Ile Thr Ile Leu Asp Lys Tyr Leu Lys Ser Gly Asp Gly Glu
            1220                1225                1230        
Gly Thr Pro Val Glu His Val Arg Cys Phe Gln Pro Pro Ile His Gln
        1235                1240                1245            
Ser Leu Ala Ser Ser
    1250            


<210> 4
<211> 822
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Glu Ser Leu Gly Ser Ala Glu Leu Leu Arg Gln Leu Lys Ser
 1               5                  10                  15      
Leu Gly Met Glu Arg Leu Leu His Ala Val Asn Thr Phe Leu Arg Gln
            20                  25                  30          
Ser Cys Thr Tyr Leu Pro Leu Leu Thr Phe Gly Gly Lys Thr Ser Phe
        35                  40                  45              
Val Ser Leu Asp Val Tyr Gly Thr Glu Ala Asn Cys Ser Ala Thr Ser
    50                  55                  60                  
Cys Ser Phe Pro Lys Ala Ala Ala Thr Trp Pro Arg Arg Gln Ala Pro
65                  70                  75                  80  
Gly Pro Leu Gly Glu Leu Val Arg Gly Pro Pro Asp Gln Gly Val Ala
                85                  90                  95      
Glu Gln Ser Phe Ser His Gly Leu Phe Glu Phe Gly Ile Thr Asn Val
            100                 105                 110         
Pro Cys Ile Phe Ser Pro Pro Gln Met Phe Pro Trp Ile Ile Gln Leu
        115                 120                 125             
Tyr Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly
    130                 135                 140                 
Ser Lys Lys Thr Leu Arg Ser Ser Leu Glu Gly Pro Thr Ile Leu Asp
145                 150                 155                 160 
Ile Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Thr His Leu Ile Asn
                165                 170                 175     
Phe Ser Glu Thr Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe
            180                 185                 190         
Arg Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe Pro
        195                 200                 205             
Ile Glu Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu Thr
    210                 215                 220                 
Lys Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr
225                 230                 235                 240 
Asn Asp Ser Ala His Tyr Ala Leu Thr Arg Phe Asn Lys Gln Phe Leu
                245                 250                 255     
Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val
            260                 265                 270         
Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly
        275                 280                 285             
Ser Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly
    290                 295                 300                 
Ala Thr Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys
305                 310                 315                 320 
Gln Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu
                325                 330                 335     
Ile Thr Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala
            340                 345                 350         
Ile Gly Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile Val Glu Leu Asp
        355                 360                 365             
Gly Leu Leu Glu Ile Asn Arg Met Thr His Lys Leu Leu Ser Arg Tyr
    370                 375                 380                 
Leu Thr Leu Asp Gly Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn
385                 390                 395                 400 
Val Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu Leu
                405                 410                 415     
Asn Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg
            420                 425                 430         
Phe Val Arg Thr Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys
        435                 440                 445             
Gln Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn
    450                 455                 460                 
Leu Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro
465                 470                 475                 480 
Pro His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala
                485                 490                 495     
Val Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly
            500                 505                 510         
Thr Ile Leu Gln Tyr Val Lys Thr Leu Met Glu Val Met Pro Lys Ile
        515                 520                 525             
Cys Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe
    530                 535                 540                 
Phe His His Gln Leu Lys Asp Ile Val Glu Tyr Ala Glu Leu Lys Thr
545                 550                 555                 560 
Val Cys Phe Gln Asn Leu Arg Glu Val Gly Asn Ala Ile Leu Phe Cys
                565                 570                 575     
Leu Leu Ile Glu Gln Ser Leu Ser Leu Glu Glu Val Cys Asp Leu Leu
            580                 585                 590         
His Ala Ala Pro Phe Gln Asn Ile Leu Pro Arg Val His Val Lys Glu
        595                 600                 605             
Gly Glu Arg Leu Asp Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala
    610                 615                 620                 
Pro Leu His Leu Val Pro Leu Ile Glu Arg Leu Gly Thr Pro Gln Gln
625                 630                 635                 640 
Ile Ala Ile Ala Arg Glu Gly Asp Leu Leu Thr Lys Glu Arg Leu Cys
                645                 650                 655     
Cys Gly Leu Ser Met Phe Glu Val Ile Leu Thr Arg Ile Arg Ser Phe
            660                 665                 670         
Leu Asp Asp Pro Ile Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met
        675                 680                 685             
His Val Asp Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met Gln
    690                 695                 700                 
Phe Val Tyr Cys Ile Pro Val Gly Thr His Glu Phe Thr Val Glu Gln
705                 710                 715                 720 
Cys Phe Gly Asp Gly Leu His Trp Ala Gly Cys Met Ile Ile Val Leu
                725                 730                 735     
Leu Gly Gln Gln Arg Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu
            740                 745                 750         
Leu Lys Val Gln Lys His Asp Gly Lys Asp Glu Ile Ile Lys Asn Val
        755                 760                 765             
Pro Leu Lys Lys Met Val Glu Arg Ile Arg Lys Phe Gln Ile Leu Asn
    770                 775                 780                 
Asp Glu Ile Ile Thr Ile Leu Asp Lys Tyr Leu Lys Ser Gly Asp Gly
785                 790                 795                 800 
Glu Gly Thr Pro Val Glu His Val Arg Cys Phe Gln Pro Pro Ile His
                805                 810                 815     
Gln Ser Leu Ala Ser Ser
            820         


<210> 5
<211> 4112
<212> DNA
<213> Murine

<400> 5
ccgccctgga caaccgaagc ggcgcagacc aggatggctg cccaagtgac actagaggac 60
gcactgtcca atgtggacct cctggaggag ctgcctctgc ctgaccagca gccctgcatc 120
gagcccccac cgtcctcgct gctctatcag ccaaatttca acaccaactt tgaagacaga 180
aatgcatttg tcactggcat tgcaagatac atcgaacaag caactgtcca ctctagcatg 240
aacgagatgc tagaggaagg ccaagagtat gctgtcatgc tgtacacctg gaggagctgc 300
tcccgggcca tccctcaggt gaagtgcaac gagcagccga atagagttga aatttatgag 360
aaaaccgtgg aagtccttga acccgaggtc acaaaactga tgaattttat gtactttcag 420
agaaatgcca tcgagcggtt ctgtggggaa gtgagacgcc tgtgtcatgc tgagaggaga 480
aaggactttg tttctgaagc ctacttgatc accctgggca aatttatcaa catgtttggt 540
gtgttggatg agctgaagaa catgaagtgc agtgtgaaga atgaccactc tgcatataag 600
agggctgctc agtttttacg taaaatggca gatccacaat ccatccagga gtcacagaat 660
ctgtccatgt tcctggccaa ccacaacaag attacacaat ctctgcagca gcagcttgag 720
gtcatttctg gctatgaaga gctcctggca gacatcgtga atctgtgtgt ggattactat 780
gagaacagga tgtacttgac acccagcgaa aaacacatgc ttctcaaagt catgggattt 840
ggcctgtacc tgatggatgg gagtgtgagt aacatctaca aactagatgc caagaaaaga 900
ataaatttat ccaaaatcga caagtatttc aagcagctgc aggtggttcc actctttgga 960
gatatgcaaa tagaactggc aagatacatc aagaccagcg cacactatga ggagaataag 1020
tcccggtgga cctgcgcgtc ctccagcagc agcccgcagt acaacatctg tgagcagatg 1080
atccagatcc gtgaggacca tatgcgtttc atctccgagc tggcacgcta cagcaatagc 1140
gaggtagtca cagggtctgg ccggcaggaa gcccagaaga cagatgctga gtaccggaag 1200
ctcttcgatc tggctctgca gggcctgcag cttctgtcgc agtggagcgc tcacgcgatg 1260
gaagtgtatt cctggaaact tgtacatcca acagacaagt actccaacaa ggactgcccc 1320
gacaacgctg aggagtacga gcgagccaca cgctacaact acaccactga ggagaagttt 1380
gccctggtgg aggtgattgc catgatcaaa ggcctgcagg tgctgatggg caggatggag 1440
agtgtgttca atcacgccat cagacacacg gtttacgctg cgcttcagga cttctcccag 1500
gtgaccctca gggaaccact gcgacaggcc atcaagaaga aaaagaacgt aatccagagt 1560
gtcctacagg ccatcaggaa gactgtgtgt gactgggaga ctgggcatga gccctttaac 1620
gacccagctc tgcggggaga gaaggaccct aagagtggct ttgacatcaa ggtgccacgc 1680
cgtgctgtgg gaccctccag cacgcagctt tacatggtga gaactatgct agagtccctc 1740
attgcagaca aaagtggttc caagaaaacc ttgagaagta gccttgaggg gcccaccata 1800
ttggacatag aaaaatttca tcgagaatca ttcttctaca ctcacttgat aaatttcagt 1860
gaaacactgc agcagtgctg tgacctttcc cagctgtggt tccgagagtt cttcctggag 1920
ctgaccatgg gcaggaggat ccagttcccc attgagatgt ctatgccctg gattctgact 1980
gaccacatcc tagagaccaa ggaggcatca atgatggagt acgtcctcta ctccttggac 2040
ctgtacaacg acagtgccca ctatgcgctc accaagttca acaagcagtt tctctatgat 2100
gagattgagg cagaggtgaa tctgtgtttt gaccaatttg tttataaact agcagaccag 2160
atatttgcat attacaaggt tatggcagga agtttgcttc ttgacaaaag gttacggtca 2220
gaatgcaaaa atcagggagc cacgatccac ctccccccat ctaaccgcta tgagacgctg 2280
ttgaagcaaa ggcacgtgca gctgctcggg agatccattg atctcaaccg tctgattaca 2340
cagcgcgttt cagcagccat gtacaaatct ctagaactgg caattggacg gtttgaaagt 2400
gaagatttaa catcagtagt cgagctagat ggactcttag aaatcaaccg tatgacacac 2460
aagctgttga gcaggtacct cacactggac agctttgatg ccatgttccg ggaagccaac 2520
cacaacgtgt ctgcacctta tggaagaatt accctccacg tcttctggga gctaaactat 2580
gacttcttgc ccaactactg ctataatggc tctaccaacc ggtttgttcg gacagtatta 2640
ccattttctc aggaatttca aagagacaaa cagcctaacg cacagcccca gtatttgcat 2700
ggatccaagg ctttgaacct agcctactca agcatttatg gcagctaccg gaactttgtg 2760
gggcctccgc acttccaagt catctgccgg ctacttggct accagggcat tgcagtagtc 2820
atggaagagc tgctgaaggt tgtcaagagc ctgctgcaag gcacaatcct gcagtacgtg 2880
aaaactctga tggaagtgat gcccaagatc tgccggcttc cgcgacatga gtacggctct 2940
cctggcatcc tggagttctt ccaccaccag ctgaaggaca ttgcggagta tgcagagctg 3000
aaaaccgtat gcttccagaa cctgcgggag gtgggcaatg ctgttctctt ctgcctgctt 3060
attgagcaaa gcctgtcttt agaagaagtc tgtgacctgt tgcatgcagc tcctttccag 3120
aatatcttac ctcgaatcca tgtaaaagag ggggagagag ttgatgccaa aatgaaaaga 3180
ctagaatcca agtatgcccc actgcacctt gtcccactga ttgaaaggct gggcacccca 3240
cagcaaattg caattgcaag agaggggcac ttgctaacca aggagcgtct ctgttgtggt 3300
ctgtccatgt ttgaagtcat cctgacacgg atccggacct ttctggatga tcccatctgg 3360
cgtgggcccc tacccagcaa tggtgtcatg cacgtggatg agtgtgtgga gtttcacaga 3420
ctatggagtg ccatgcagtt tgtttactgc attcctgtag ggacacacga gtttacagtg 3480
gagcagtgtt ttggagatgg gctccactgg gctggctgca tgatcattgt acttcttgga 3540
cagcagcggc gctttgctgt gttggatttc tgctatcatc ttctcaaagt tcagaaacat 3600
gatggcaaag atgagatcat caaaaatgtg ccattgaaga agatggtgga gaggatccgc 3660
aagttccaga ttctcaacga tgaaatcatc actatcctgg acaagtactt gaaatctggt 3720
gatggcgaga cgacacctgt ggagcatgta cgctgcttcc agccacccat ccaccagtcc 3780
ctagccagta gctgagggct aagctcacag catcccagta actgatggca tgtttgtctt 3840
tatgtaaact atattgaaat ttttaggggc tattttccat tatgtctgaa cctacttttg 3900
atctgaaagc ttaactttat aaaatttact tatttttcta tactaaaatt gtatatgcct 3960
ttggaattgg gaagtctgag aatacggtta ctagttgttg ccattacggt attaacaagt 4020
attttcatgc cgaatattcc agcagctatt ataatgctaa atcactcatc tgtacgagca 4080
taaccactaa ttgtattaaa aaaaaataaa aa                               4112

<210> 6
<211> 1253
<212> PRT
<213> Murine

<400> 6
Met Ala Ala Gln Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu
 1               5                  10                  15      
Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro
            20                  25                  30          
Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Thr Asn Phe Glu Asp
        35                  40                  45              
Arg Asn Ala Phe Val Thr Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr
    50                  55                  60                  
Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala
65                  70                  75                  80  
Val Met Leu Tyr Thr Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val
                85                  90                  95      
Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Thr Val
            100                 105                 110         
Glu Val Leu Glu Pro Glu Val Thr Lys Leu Met Asn Phe Met Tyr Phe
        115                 120                 125             
Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys
    130                 135                 140                 
His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Ile Thr
145                 150                 155                 160 
Leu Gly Lys Phe Ile Asn Met Phe Gly Val Leu Asp Glu Leu Lys Asn
                165                 170                 175     
Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala
            180                 185                 190         
Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln
        195                 200                 205             
Asn Leu Ser Met Phe Leu Ala Asn His Asn Lys Ile Thr Gln Ser Leu
    210                 215                 220                 
Gln Gln Gln Leu Glu Val Ile Ser Gly Tyr Glu Glu Leu Leu Ala Asp
225                 230                 235                 240 
Ile Val Asn Leu Cys Val Asp Tyr Tyr Glu Asn Arg Met Tyr Leu Thr
                245                 250                 255     
Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr
            260                 265                 270         
Leu Met Asp Gly Ser Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys
        275                 280                 285             
Arg Ile Asn Leu Ser Lys Ile Asp Lys Tyr Phe Lys Gln Leu Gln Val
    290                 295                 300                 
Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys
305                 310                 315                 320 
Thr Ser Ala His Tyr Glu Glu Asn Lys Ser Arg Trp Thr Cys Ala Ser
                325                 330                 335     
Ser Ser Ser Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Ile Gln Ile
            340                 345                 350         
Arg Glu Asp His Met Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn
        355                 360                 365             
Ser Glu Val Val Thr Gly Ser Gly Arg Gln Glu Ala Gln Lys Thr Asp
    370                 375                 380                 
Ala Glu Tyr Arg Lys Leu Phe Asp Leu Ala Leu Gln Gly Leu Gln Leu
385                 390                 395                 400 
Leu Ser Gln Trp Ser Ala His Ala Met Glu Val Tyr Ser Trp Lys Leu
                405                 410                 415     
Val His Pro Thr Asp Lys Tyr Ser Asn Lys Asp Cys Pro Asp Asn Ala
            420                 425                 430         
Glu Glu Tyr Glu Arg Ala Thr Arg Tyr Asn Tyr Thr Thr Glu Glu Lys
        435                 440                 445             
Phe Ala Leu Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu
    450                 455                 460                 
Met Gly Arg Met Glu Ser Val Phe Asn His Ala Ile Arg His Thr Val
465                 470                 475                 480 
Tyr Ala Ala Leu Gln Asp Phe Ser Gln Val Thr Leu Arg Glu Pro Leu
                485                 490                 495     
Arg Gln Ala Ile Lys Lys Lys Lys Asn Val Ile Gln Ser Val Leu Gln
            500                 505                 510         
Ala Ile Arg Lys Thr Val Cys Asp Trp Glu Thr Gly His Glu Pro Phe
        515                 520                 525             
Asn Asp Pro Ala Leu Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp
    530                 535                 540                 
Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Thr Gln Leu Tyr
545                 550                 555                 560 
Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser
                565                 570                 575     
Lys Lys Thr Leu Arg Ser Ser Leu Glu Gly Pro Thr Ile Leu Asp Ile
            580                 585                 590         
Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Thr His Leu Ile Asn Phe
        595                 600                 605             
Ser Glu Thr Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg
    610                 615                 620                 
Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe Pro Ile
625                 630                 635                 640 
Glu Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu Thr Lys
                645                 650                 655     
Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn
            660                 665                 670         
Asp Ser Ala His Tyr Ala Leu Thr Lys Phe Asn Lys Gln Phe Leu Tyr
        675                 680                 685             
Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr
    690                 695                 700                 
Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser
705                 710                 715                 720 
Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly Ala
                725                 730                 735     
Thr Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gln
            740                 745                 750         
Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile
        755                 760                 765             
Thr Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala Ile
    770                 775                 780                 
Gly Arg Phe Glu Ser Glu Asp Leu Thr Ser Val Val Glu Leu Asp Gly
785                 790                 795                 800 
Leu Leu Glu Ile Asn Arg Met Thr His Lys Leu Leu Ser Arg Tyr Leu
                805                 810                 815     
Thr Leu Asp Ser Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val
            820                 825                 830         
Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu Leu Asn
        835                 840                 845             
Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe
    850                 855                 860                 
Val Arg Thr Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys Gln
865                 870                 875                 880 
Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn Leu
                885                 890                 895     
Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro
            900                 905                 910         
His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val
        915                 920                 925             
Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly Thr
    930                 935                 940                 
Ile Leu Gln Tyr Val Lys Thr Leu Met Glu Val Met Pro Lys Ile Cys
945                 950                 955                 960 
Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe
                965                 970                 975     
His His Gln Leu Lys Asp Ile Ala Glu Tyr Ala Glu Leu Lys Thr Val
            980                 985                 990         
Cys Phe Gln Asn Leu Arg Glu Val Gly Asn Ala Val Leu Phe Cys Leu
        995                 1000                1005            
Leu Ile Glu Gln Ser Leu Ser Leu Glu Glu Val Cys Asp Leu Leu His
    1010                1015                1020                
Ala Ala Pro Phe Gln Asn Ile Leu Pro Arg Ile His Val Lys Glu Gly
1025                1030                1035               1040 
Glu Arg Val Asp Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala Pro
                1045                1050                1055    
Leu His Leu Val Pro Leu Ile Glu Arg Leu Gly Thr Pro Gln Gln Ile
            1060                1065                1070        
Ala Ile Ala Arg Glu Gly His Leu Leu Thr Lys Glu Arg Leu Cys Cys
        1075                1080                1085            
Gly Leu Ser Met Phe Glu Val Ile Leu Thr Arg Ile Arg Thr Phe Leu
    1090                1095                1100                
Asp Asp Pro Ile Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met His
1105                1110                1115               1120 
Val Asp Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met Gln Phe
                1125                1130                1135    
Val Tyr Cys Ile Pro Val Gly Thr His Glu Phe Thr Val Glu Gln Cys
            1140                1145                1150        
Phe Gly Asp Gly Leu His Trp Ala Gly Cys Met Ile Ile Val Leu Leu
        1155                1160                1165            
Gly Gln Gln Arg Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu Leu
    1170                1175                1180                
Lys Val Gln Lys His Asp Gly Lys Asp Glu Ile Ile Lys Asn Val Pro
1185                1190                1195               1200 
Leu Lys Lys Met Val Glu Arg Ile Arg Lys Phe Gln Ile Leu Asn Asp
                1205                1210                1215    
Glu Ile Ile Thr Ile Leu Asp Lys Tyr Leu Lys Ser Gly Asp Gly Glu
            1220                1225                1230        
Thr Thr Pro Val Glu His Val Arg Cys Phe Gln Pro Pro Ile His Gln
        1235                1240                1245            
Ser Leu Ala Ser Ser
    1250            


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 7
tccatccagg agtcacagaa                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 8
agccagaaat gacctcaagc                                             20

<210> 9
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 9
cagggtcaca aaactgatga at                                          22

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
tcctctcagc atgacacagg                                             20

<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 11
ccagcagcca tgtatcgag                                              19

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 12
tcctcgaagt tcgtgtcaaa                                             20

<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 13
cagtccatcc aggaatctca g                                           21

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 14
cacttccagt tgctggtgaa                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 15
ccccgaagtc tgagagtgtg                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 16
aggtagccca caaacactgg                                             20

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
gagttggagg agaagctgac c                                           21

<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
tcaacagcag cagcatgag                                              19

<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
ttttcattgg agggagtttc a                                           21

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 20
atatgcatgg cctccttgac                                             20

<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 21
tggtctggga ttggctatg                                              19

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 22
atatgcatgg cctccttgac                                             20

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 23
gctgaagaac ctcaactgtg c                                           21

<210> 24
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 24
gagggtatat aagcttttct ttctgc                                      26

<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 25
cctcaagtct gctgggaaga                                             20

<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 26
tccagtactg atgaactaca tgctg                                       25

<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 27
ggatgcagaa ggagattact gc                                          22

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 28
ccaccgatcc acacagagta                                             20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 29
gaggatcaac agtgcccatt                                             20

<210> 30
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 30
agcctcaaag gggaggtg                                               18

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 31
catgaggtcg ggtggaagta                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 32
gcctgtttcc gtaacctcaa                                             20

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 33
ctcaacacgg gaaacctcac                                             20

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 34
cgctccacca actaagaacg                                             20
