                         SEQUENCE LISTING

<110>  ETAT FRANCAIS reprsent par le Dlgu Gnral pour 
       l'Armement
       LFB Biotechnologies
 
<120>  Anticorps chimrique anti ricine

<130>  WOB 09 AW LFB RICI

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  321
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  CDS
<222>  (1)..(321)

<400>  1
gag ctc cag atg aca cag tct cca tcc tcc ctg tct gca tct gta gga         48
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgt cgg gca agt cag agc att aga agt tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gat gca gcc cat ttg caa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Asp Ala Ala His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc agt ctc acc atc agc agc ctg caa cct        240
Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt caa cag cgt aat agt tat cct ctg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Ser Tyr Pro Leu           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  2
<211>  107
<212>  PRT
<213>  Macaca fascicularis

<400>  2

Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ala His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  360
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  CDS
<222>  (1)..(360)

<400>  3
cag gtg cag ctg gtg gag tcg ggg ggc ggc ttg gta aag cct ggg ggg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgc gca gcc tcc gga ttc acc ttc act gac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr           
            20                  25                  30                    

tac atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca cgt att agc cct ggt ggt gat gtc aca tgg tac gca gac tcc gtg        192
Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc aga ttt acc atc tcc aga gac aac gcc cag aac aca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr           
65                  70                  75                  80            

ctt caa atg aac agc ctg aga gct gag gac acg gct gtc tat ttc tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga gat gat ata gtg gtg tcc aga att ttt gat gac tgg ggc cag        336
Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp Trp Gly Gln           
            100                 105                 110                   

gga gtc ctg gtc acc gtc tcc tca                                        360
Gly Val Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  4
<211>  120
<212>  PRT
<213>  Macaca fascicularis

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp Trp Gly Gln 
            100                 105                 110         


Gly Val Leu Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hybride homme/macaque


<220>
<221>  CDS
<222>  (1)..(642)

<400>  5
gag ctc cag atg aca cag tct cca tcc tcc ctg tct gca tct gta gga         48
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgt cgg gca agt cag agc att aga agt tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gat gca gcc cat ttg caa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Asp Ala Ala His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc agt ctc acc atc agc agc ctg caa cct        240
Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt caa cag cgt aat agt tat cct ctg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Ser Tyr Pro Leu           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gag atc aaa cga act gtg gct gca        336
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cca agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac agg gga gag tgt                                                642
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  6
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6

Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ala His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  1350
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hybride homme/macaque


<220>
<221>  CDS
<222>  (1)..(1350)

<400>  7
cag gtg cag ctg gtg gag tcg ggg ggc ggc ttg gta aag cct ggg ggg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgc gca gcc tcc gga ttc acc ttc act gac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr           
            20                  25                  30                    

tac atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca cgt att agc cct ggt ggt gat gtc aca tgg tac gca gac tcc gtg        192
Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc aga ttt acc atc tcc aga gac aac gcc cag aac aca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr           
65                  70                  75                  80            

ctt caa atg aac agc ctg aga gct gag gac acg gct gtc tat ttc tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga gat gat ata gtg gtg tcc aga att ttt gat gac tgg ggc cag        336
Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp Trp Gly Gln           
            100                 105                 110                   

gga gtc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc cca tcg gtc        384
Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val           
        115                 120                 125                       

ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc        432
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala           
    130                 135                 140                           

ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg        480
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser           
145                 150                 155                 160           

tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc        528
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val           
                165                 170                 175               

cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc        576
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro           
            180                 185                 190                   

tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag        624
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys           
        195                 200                 205                       

ccc agc aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac        672
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp           
    210                 215                 220                           

aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga        720
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly           
225                 230                 235                 240           

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        768
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
                245                 250                 255               

tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa        816
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
            260                 265                 270                   

gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat        864
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
        275                 280                 285                       

aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt        912
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg           
    290                 295                 300                           

gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag        960
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
305                 310                 315                 320           

gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag       1008
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu           
                325                 330                 335               

aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac       1056
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
            340                 345                 350                   

acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg       1104
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu           
        355                 360                 365                       

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg       1152
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
    370                 375                 380                           

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg       1200
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
385                 390                 395                 400           

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac       1248
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
                405                 410                 415               

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       1296
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
            420                 425                 430                   

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       1344
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
        435                 440                 445                       

ggt aaa                                                               1350
Gly Lys                                                                   
    450                                                                   


<210>  8
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp Trp Gly Gln 
            100                 105                 110         


Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  9
<211>  387
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  CDS
<222>  (1)..(387)

<400>  9
atg gac atg agg gtc ccc gct cag ctc ctg ggg ctt ctg ctg ctc tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctc cca ggt gcc aga tgt gag ctc cag atg aca cag tct cca tcc tcc         96
Leu Pro Gly Ala Arg Cys Glu Leu Gln Met Thr Gln Ser Pro Ser Ser           
            20                  25                  30                    

ctg tct gca tct gta gga gac aga gtc acc atc act tgt cgg gca agt        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

cag agc att aga agt tat tta gcc tgg tat cag cag aaa cca ggg aaa        192
Gln Ser Ile Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys           
    50                  55                  60                            

gcc cct aag ctc ctg atc tat gat gca gcc cat ttg caa agt ggg gtc        240
Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ala His Leu Gln Ser Gly Val           
65                  70                  75                  80            

cca tca agg ttc agc ggc agt gga tct ggg aca gaa ttc agt ctc acc        288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr           
                85                  90                  95                

atc agc agc ctg caa cct gaa gat ttt gca gtt tat tac tgt caa cag        336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln           
            100                 105                 110                   

cgt aat agt tat cct ctg act ttc ggc gga ggg acc aag gtg gag atc        384
Arg Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile           
        115                 120                 125                       

aaa                                                                    387
Lys                                                                       
                                                                          


<210>  10
<211>  129
<212>  PRT
<213>  Macaca fascicularis

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Glu Leu Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ala His Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Arg Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys 
    


<210>  11
<211>  417
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  CDS
<222>  (1)..(417)

<400>  11
atg aaa cat ctg tgg ttc ttc ctt ctc ctg gtg gca gct ccc aga tgg         48
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp           
1               5                   10                  15                

gtc ctg tcc cag gtg cag ctg gtg gag tcg ggg ggc ggc ttg gta aag         96
Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys           
            20                  25                  30                    

cct ggg ggg tcc ctg aga ctc tcc tgc gca gcc tcc gga ttc acc ttc        144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
        35                  40                  45                        

act gac tac tac atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg        192
Thr Asp Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
    50                  55                  60                            

gag tgg gtc tca cgt att agc cct ggt ggt gat gtc aca tgg tac gca        240
Glu Trp Val Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala           
65                  70                  75                  80            

gac tcc gtg aag ggc aga ttt acc atc tcc aga gac aac gcc cag aac        288
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn           
                85                  90                  95                

aca ctg tat ctt caa atg aac agc ctg aga gct gag gac acg gct gtc        336
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val           
            100                 105                 110                   

tat ttc tgt gcg aga gat gat ata gtg gtg tcc aga att ttt gat gac        384
Tyr Phe Cys Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp           
        115                 120                 125                       

tgg ggc cag gga gtc ctg gtc acc gtc tcc tca                            417
Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser                               
    130                 135                                               


<210>  12
<211>  139
<212>  PRT
<213>  Macaca fascicularis

<400>  12

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp 
        115                 120                 125             


Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
    130                 135                 


<210>  13
<211>  708
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hybride homme/macaque


<220>
<221>  CDS
<222>  (1)..(708)

<400>  13
atg gac atg agg gtc ccc gct cag ctc ctg ggg ctt ctg ctg ctc tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctc cca ggt gcc aga tgt gag ctc cag atg aca cag tct cca tcc tcc         96
Leu Pro Gly Ala Arg Cys Glu Leu Gln Met Thr Gln Ser Pro Ser Ser           
            20                  25                  30                    

ctg tct gca tct gta gga gac aga gtc acc atc act tgt cgg gca agt        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

cag agc att aga agt tat tta gcc tgg tat cag cag aaa cca ggg aaa        192
Gln Ser Ile Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys           
    50                  55                  60                            

gcc cct aag ctc ctg atc tat gat gca gcc cat ttg caa agt ggg gtc        240
Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ala His Leu Gln Ser Gly Val           
65                  70                  75                  80            

cca tca agg ttc agc ggc agt gga tct ggg aca gaa ttc agt ctc acc        288
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr           
                85                  90                  95                

atc agc agc ctg caa cct gaa gat ttt gca gtt tat tac tgt caa cag        336
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln           
            100                 105                 110                   

cgt aat agt tat cct ctg act ttc ggc gga ggg acc aag gtg gag atc        384
Arg Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile           
        115                 120                 125                       

aaa cga act gtg gct gca cca agt gtc ttc atc ttc ccg cca tct gat        432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp           
    130                 135                 140                           

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac        480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn           
145                 150                 155                 160           

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc        528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu           
                165                 170                 175               

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac        576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp           
            180                 185                 190                   

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac        624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr           
        195                 200                 205                       

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc        672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser           
    210                 215                 220                           

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt                        708
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                           
225                 230                 235                               


<210>  14
<211>  236
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Glu Leu Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ala His Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Arg Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  15
<211>  1407
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hybride homme/macaque


<220>
<221>  CDS
<222>  (1)..(1407)

<400>  15
atg aaa cat ctg tgg ttc ttc ctt ctc ctg gtg gca gct ccc aga tgg         48
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp           
1               5                   10                  15                

gtc ctg tcc cag gtg cag ctg gtg gag tcg ggg ggc ggc ttg gta aag         96
Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys           
            20                  25                  30                    

cct ggg ggg tcc ctg aga ctc tcc tgc gca gcc tcc gga ttc acc ttc        144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
        35                  40                  45                        

act gac tac tac atg gac tgg gtc cgc cag gct cca ggg aag ggg ctg        192
Thr Asp Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
    50                  55                  60                            

gag tgg gtc tca cgt att agc cct ggt ggt gat gtc aca tgg tac gca        240
Glu Trp Val Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala           
65                  70                  75                  80            

gac tcc gtg aag ggc aga ttt acc atc tcc aga gac aac gcc cag aac        288
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn           
                85                  90                  95                

aca ctg tat ctt caa atg aac agc ctg aga gct gag gac acg gct gtc        336
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val           
            100                 105                 110                   

tat ttc tgt gcg aga gat gat ata gtg gtg tcc aga att ttt gat gac        384
Tyr Phe Cys Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp           
        115                 120                 125                       

tgg ggc cag gga gtc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc        432
Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly           
    130                 135                 140                           

cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc        480
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly           
145                 150                 155                 160           

aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg        528
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val           
                165                 170                 175               

acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc        576
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe           
            180                 185                 190                   

ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg        624
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val           
        195                 200                 205                       

acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg        672
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val           
    210                 215                 220                           

aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc aaa        720
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys           
225                 230                 235                 240           

tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc        768
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu           
                245                 250                 255               

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc        816
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
            260                 265                 270                   

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg        864
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
        275                 280                 285                       

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg        912
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val           
    290                 295                 300                           

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc        960
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser           
305                 310                 315                 320           

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg       1008
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu           
                325                 330                 335               

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc       1056
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala           
            340                 345                 350                   

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca       1104
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro           
        355                 360                 365                       

cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag       1152
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln           
    370                 375                 380                           

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc       1200
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
385                 390                 395                 400           

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg       1248
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
                405                 410                 415               

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc       1296
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
            420                 425                 430                   

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc       1344
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
        435                 440                 445                       

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc       1392
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
    450                 455                 460                           

ctg tct ccg ggt aaa                                                   1407
Leu Ser Pro Gly Lys                                                       
465                                                                       


<210>  16
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Arg Ile Ser Pro Gly Gly Asp Val Thr Trp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Asp Ile Val Val Ser Arg Ile Phe Asp Asp 
        115                 120                 125             


Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  17
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  squence leader


<220>
<221>  CDS
<222>  (1)..(57)

<400>  17
atg aaa cat ctg tgg ttc ttc ctt ctc ctg gtg gca gct ccc aga tgg         48
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp           
1               5                   10                  15                

gtc ctg tcc                                                             57
Val Leu Ser                                                               
                                                                          


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  19
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  squence leader


<220>
<221>  CDS
<222>  (1)..(66)

<400>  19
atg gac atg agg gtc ccc gct cag ctc ctg ggg ctt ctg ctg ctc tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctc cca ggt gcc aga tgt                                                 66
Leu Pro Gly Ala Arg Cys                                                   
            20                                                            


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  21
<211>  10763
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vecteur d'expression

<400>  21
gatctcccga tcccctatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa       60

gccagtatct gctccctgct tgtgtgttgg aggtcgctga gtagtgcgcg agcaaaattt      120

aagctacaac aaggcaaggc ttgaccgaca attgcatgaa gaatctgctt agggttaggc      180

gttttgcgct gcttcgcgat gtacgggcca gatatacgcg tatctgaggg gactagggtg      240

tgtttaggcg aaaagcgggg cttcggttgt acgcggttag gagtcccctc aggatatagt      300

agtttcgctt ttgcataggg agggggaaat gtagtcttat gcaatactct tgtagtcttg      360

caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc accgtgcatg      420

ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac agacgggtct      480

gacatggatt ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta      540

gctcgataca ataaacgcca tttgaccatt caccacattg gtgtgcacct ccaagcttgg      600

taccgagctc ggatccacta gagcagaagt tggtcgtgag gcactgggca ggtaagtatc      660

aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag acagagaaga      720

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc      780

acaggtgtcc actcccagtt caattacagc tcttgctagc gccgccacca tgaaacatct      840

gtggttcttc cttctcctgg tggcagctcc cagatgggtc ctgtcccagg tgcagctggt      900

ggagtcgggg ggcggcttgg taaagcctgg ggggtccctg agactctcct gcgcagcctc      960

cggattcacc ttcactgact actacatgga ctgggtccgc caggctccag ggaaggggct     1020

ggagtgggtc tcacgtatta gccctggtgg tgatgtcaca tggtacgcag actccgtgaa     1080

gggcagattt accatctcca gagacaacgc ccagaacaca ctgtatcttc aaatgaacag     1140

cctgagagct gaggacacgg ctgtctattt ctgtgcgaga gatgatatag tggtgtccag     1200

aatttttgat gactggggcc agggagtcct ggtcaccgtc tcctcagcct ccaccaaggg     1260

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct     1320

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc     1380

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct     1440

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt     1500

gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa     1560

aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct     1620

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt     1680

ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt     1740

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt     1800

ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa     1860

ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca     1920

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca     1980

ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga     2040

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg     2100

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt     2160

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc     2220

cctgtctccg ggtaaatgat agggcgcgcc gctagagagg atcccgggtg gcatccctgt     2280

gacccctccc cagtgcctct cctggccctg gaagttgcca ctccagtgcc caccagcctt     2340

gtcctaataa aattaagttg catcattttg tctgactagg tgtccttcta taatattatg     2400

gggtggaggg gggtggtatg gagcaagggg caagttggga agacaacctg tagggcctgc     2460

ggggtctatt gggaaccaag ctggagtgca gtggcacaat cttggctcac tgcaatctcc     2520

gcctcctggg ttcaagcgat tctcctgcct cagcctcccg agttgttggg attccaggca     2580

tgcatgacca ggctcagcta atttttgttt ttttggtaga gacggggttt caccatattg     2640

gccaggctgg tctccaactc ctaatctcag gtgatctacc caccttggcc tcccaaattg     2700

ctgggattac aggcgtgaac cactgctccc ttccctgtcc ttctgatttt aaaataacta     2760

taccagcagg aggacgtcca gacacagcat aggctacctg gccatgccca accggtggga     2820

catttgagtt gcttgcttgg cactgtcctc tcatgcgttg ggtccactca gtagatgcct     2880

gttcatatgc tcgagatctc ccgatcccct atggtgcact ctcagtacaa tctgctctga     2940

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg     3000

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct     3060

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgtatctg     3120

aggggactag ggtgtgttta ggcgaaaagc ggggcttcgg ttgtacgcgg ttaggagtcc     3180

cctcaggata tagtagtttc gcttttgcat agggaggggg aaatgtagtc ttatgcaata     3240

ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa     3300

aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg     3360

caacagacgg gtctgacatg gattggacga accactgaat tccgcattgc agagatattg     3420

tatttaagtg cctagctcga tacaataaac gccatttgac cattcaccac attggtgtgc     3480

acctccaagc ttggtaccga gctcggatcc actagagcag aagttggtcg tgaggcactg     3540

ggcaggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt     3600

cgagacagag aagactcttg cgtttctgat aggcacctat tggtcttact gacatccact     3660

ttgcctttct ctccacaggt gtccactccc agttcaatta cagctcttac tagtgccgcc     3720

accatggaca tgagggtccc cgctcagctc ctggggcttc tgctgctctg gctcccaggt     3780

gccagatgtg agctccagat gacacagtct ccatcctccc tgtctgcatc tgtaggagac     3840

agagtcacca tcacttgtcg ggcaagtcag agcattagaa gttatttagc ctggtatcag     3900

cagaaaccag ggaaagcccc taagctcctg atctatgatg cagcccattt gcaaagtggg     3960

gtcccatcaa ggttcagcgg cagtggatct gggacagaat tcagtctcac catcagcagc     4020

ctgcaacctg aagattttgc agtttattac tgtcaacagc gtaatagtta tcctctgact     4080

ttcggcggag ggaccaaggt ggagatcaaa cgaactgtgg ctgcaccaag tgtcttcatc     4140

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat     4200

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt     4260

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc     4320

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc     4380

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttagtgaact     4440

ctagagctcg ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc     4500

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     4560

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     4620

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gacatatgat     4680

ttaaatactg gggctcgact gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc     4740

tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga     4800

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     4860

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     4920

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc     4980

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     5040

cttggggggg gggacagctc agggctgcga tttcgcgcca aacttgacgg caatcctagc     5100

gtgaaggctg gtaggatttt atccccgctg ccatcatggt tcgaccattg aactgcatcg     5160

tcgccgtgtc ccaaaatatg gggattggca agaacggaga cctaccctgg cctccgctca     5220

ggaacgagtt caagtacttc caaagaatga ccacaacctc ttcagtggaa ggtaaacaga     5280

atctggtgat tatgggtagg aaaacctggt tctccattcc tgagaagaat cgacctttaa     5340

aggacagaat taatatagtt ctcagtagag aactcaaaga accaccacga ggagctcatt     5400

ttcttgccaa aagtttggat gatgccttaa gacttattga acaaccggaa ttggcaagta     5460

aagtagacat ggtttggata gtcggaggca gttctgttta ccaggaagcc atgaatcaac     5520

caggccacct cagactcttt gtgacaagga tcatgcagga atttgaaagt gacacgtttt     5580

tcccagaaat tgatttgggg aaatataaac ttctcccaga atacccaggc gtcctctctg     5640

aggtccagga ggaaaaaggc atcaagtata agtttgaagt ctacgagaag aaagactaac     5700

aggaagatgc tttcaagttc tctgctcccc tcctaaagct atgcattttt ataagaccat     5760

gggacttttg ctggctttag atcgatcttt gtgaaggaac cttacttctg tggtgtgaca     5820

taattggaca aactacctac agagatttaa agctctaagg taaatataaa atttttaagt     5880

gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga     5940

actgatgaat gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa     6000

gaaatgccat ctagtgatga tgaggctact gctgactctc aacattctac tcctccaaaa     6060

aagaagagaa aggtagaaga ccccaaggac tttccttcag aattgctaag ttttttgagt     6120

catgctgtgt ttagtaatag aactcttgct tgctttgcta tttacaccac aaaggaaaaa     6180

gctgcactgc tatacaagaa aattatggaa aaatattctg taacctttat aagtaggcat     6240

aacagttata atcataacat actgtttttt cttactccac acaggcatag agtgtctgct     6300

attaataact atgctcaaaa attgtgtacc tttagctttt taatttgtaa aggggttaat     6360

aaggaatatt tgatgtatag tgccttgact agagatcata atcagccata ccacatttgt     6420

agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat     6480

gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa     6540

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     6600

caaactcatc aatgtatctt atcatgtctg gatccgcgta tggtgcactc tcagtacaat     6660

ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc     6720

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag     6780

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt     6840

gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga gatctcgagg     6900

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     6960

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     7020

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     7080

aatttaacgc gaattttaac aaaatattaa cgcttacaat ttcctgatgc ggtattttct     7140

ccttacgcat ctgtgcggta tttcacaccg catacgcgga tctgcgcagc accatggcct     7200

gaaataacct ctgaaagagg aacttggtta ggtaccttct gaggcggaaa gaaccagctg     7260

tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg cagaagtatg     7320

caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg ctccccagca     7380

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact     7440

ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     7500

atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag     7560

tgaggaggct tttttggagg cctaggcttt tgcaaaaagc ttgattcttc tgacacaaca     7620

gtctcgaact taaggctaga gccaccatga ttgaacaaga tggattgcac gcaggttctc     7680

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     7740

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     7800

acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca     7860

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     7920

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     7980

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     8040

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     8100

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     8160

ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct     8220

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     8280

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     8340

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     8400

agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc tggggttcga     8460

aatgaccgac caagcgacgc ccaacctgcc atcacgatgg ccgcaataaa atatctttat     8520

tttcattaca tctgtgtgtt ggttttttgt gtgaatcgat agcgataagg atcgatcctc     8580

tagctagagt cgatcgacct gcagggatcc gcgtatggtg cactctcagt acaatctgct     8640

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     8700

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     8760

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     8820

gcctattttt ataggttaat gtcatgataa taatggtttc ttagagatct tagatccagt     8880

tgaactgcag ggaaatccgg acgtgtatac cagtttaaac atgttaatta agtcgacgcg     8940

gccgcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     9000

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     9060

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     9120

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     9180

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     9240

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     9300

ggcgcggtga tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     9360

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     9420

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     9480

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     9540

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     9600

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     9660

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     9720

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     9780

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     9840

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     9900

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     9960

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt    10020

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac    10080

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc    10140

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca    10200

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta    10260

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct    10320

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg    10380

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc    10440

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta    10500

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg    10560

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt    10620

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg    10680

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg    10740

ccttttgctc acatggctcg aca                                            10763


<210>  22
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce sens leader VH chaine lourde humaine

<400>  22
ctcagtgcta gcgccgccac catgaaacat ctgtggt                                37


<210>  23
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce antisens leader VH chaine lourde humaine

<400>  23
ccagctgcac ctgggacagg acccat                                            26


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce sens VH chaine lourde de macaque

<400>  24
atgggtcctg tcccaggtgc agctgg                                            26


<210>  25
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce antisens VH chaine lourde de macaque

<400>  25
accgatgggc ccttggtgga ggctgaggag acggtgacca                             40


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce sens leader VK chaine lgre humaine

<400>  26
ctcagtacta gtgccgccac catggacatg agggtccccg                             40


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce antisens leader VK chaine lgre humaine

<400>  27
tgtcatctgg agctcacatc tggcacctgg                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce sens VK chaine lgre de macaque

<400>  28
ccaggtgcca gatgtgagct ccagatgaca                                        30


<210>  29
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce antisens VK chaine lgre de macaque

<400>  29
tgaagacact tggtgcagcc acagttcgtt tgatctccac cttggtcc                    48


