
                                SEQUENCE LISTING

<110> AVI BioPharma, Inc.
      Iversen, Patrick L.

<120> ANTISENSE ANTIVIRAL COMPOUND AND METHOD
  FOR TREATING INFLUENZA VIRAL INFECTION
  

<130> 120178.456PC

<140> PCT                 
<141> 2010-11-12  

<150> US 61/377,382
<151> 2010-08-26

<150> US 61/292,056
<151> 2010-01-04

<150> US 61/261,278
<151> 2019-11-13

<160> 133

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 60
<212> RNA
<213> Influenza A virus

<400> 1
agcaaaagca gguagauauu uaaagaugag ucuucuaacc gaggucgaaa cguacguucu 60


<210> 2
<211> 45
<212> RNA
<213> Influenza A virus

<400> 2
aagcagguag auauuuaaag augagucuuc uaaccgaggu cgaaa                 45

<210> 3
<211> 25
<212> RNA
<213> Influenza A virus

<400> 3
agcaaaagca gguagauauu uaaag                                       25

<210> 4
<211> 25
<212> RNA
<213> Influenza A virus

<400> 4
cuuuaaauau cuaccugcuu uugcu                                       25

<210> 5
<211> 60
<212> RNA
<213> Influenza A virus

<400> 5
agcgaaagca gguagauauu gaaagaugag ucuucuaacc gaggucgaaa cguacguucu 60


<210> 6
<211> 60
<212> RNA
<213> Influenza A virus

<400> 6
agcaaaagca gguagauauu gaaagaugag ucuucuaacc gaggucgaaa cguacguucu 60


<210> 7
<211> 60
<212> RNA
<213> Influenza A virus

<400> 7
agcaaaagca gguagauauu gaaagaugag ccuucuaacc gaggucgaaa cguauguucu 60


<210> 8
<211> 60
<212> RNA
<213> Influenza A virus

<400> 8
agcaaaagca gguagauauu gaaagaugag ucuucuaacc gaggucgaaa cguacguucu 60


<210> 9
<211> 51
<212> RNA
<213> Influenza A virus

<400> 9
aaauuugcag gccuaccaga aacgaauggg agugcagaug cagcgauuca a          51

<210> 10
<211> 51
<212> RNA
<213> Influeza A virus

<400> 10
aaauuugcag gccuaccaga agcgaauggg agugcagaug cagcgauuca a          51

<210> 11
<211> 1027
<212> DNA
<213> Influenza A virus

<400> 11
agcgaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgttct 60
ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt 120
tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct 180
gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg 240
aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa 300
catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc 360
caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata 420
caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga 480
acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaacccact 540
aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat 600
ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctaggcaaat 660
ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga 720
tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa 780
gtgatcctct cgctattgcc gcaaatatca ttgggatctt gcacttgata ttgtggattc 840
ttgatcgtct ttttttcaaa tgcatttacc gtcgctttaa atacggactg aaaggagggc 900
cttctacgga aggagtgcca aagtctatga gggaagaata tcgaaaggaa cagcagagtg 960
ctgtggatgc tgacgatggt cattttgtca gcatagagct ggagtaaaaa actaccttgt 1020
ttctact                                                           1027

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 12
cggttagaag actcatcttt                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (4)...(5)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (12)...(13)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (17)...(18)
<223> Cationic linkage between bases

<400> 13
cggttagaag actcatcttt                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 14
agaagactca tctttcaata                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 15
ttagaagact catctttcaa                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 16
ctcggttaga agactcatct                                             20

<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 17
atctttcaat atctacctgc ttttg                                       25

<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 18
ctcatctttc aatatctacc tgctt                                       25

<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 19
ctcggttaga agactcatct ttcaa                                       25

<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 20
acctcggtta gaagactcat ctttc                                       25

<210> 21
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 21
tcgacctcgg ttagaagact catct                                       25

<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 22
tttcgacctc ggttagaaga ctcat                                       25

<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 23
agcaaaagca ggtagatatt gaaaa                                       25

<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 24
agcaggtaga tattgaaaaa tgagt                                       25

<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 25
ctcccattcg cttctggtag gcct                                        24

<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 26
cactcccatt cgcttctggt aggc                                        24

<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 27
tgcactccca ttcgcttctg gtag                                        24

<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 28
tctgcactcc cattcgcttc tggt                                        24

<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 29
catctgcact cccattcgct tctg                                        24

<210> 30
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> modified_base  
<222> 12
<223> I

<400> 30
agcaaaagca gngtagataa tc                                          22

<210> 31
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> modified_base  
<222> 12
<223> I

<220> 
<221> misc_feature   
<222> (13)...(4)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (17)...(18)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (20)...(21)
<223> Cationic linkage between bases

<400> 31
agcaaaagca gngtagataa tc                                          22

<210> 32
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<400> 32
cggattgaca tccattcaaa tg                                          22

<210> 33
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (5)...(6)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (10)...(11)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (15)...(16)
<223> Cationic linkage between bases

<400> 33
cggattgaca tccattcaaa tg                                          22

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (3)...(4)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (7)...(8)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (15)...(16)
<223> Cationic linkage between bases

<400> 34
ctttcaatat ctacctgctt                                             20

<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (1)...(2)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (4)...(5)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (12)...(13)
<223> Cationic linkage between bases

<400> 35
ctcatctttc aatatctacc                                             20

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (2)...(3)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (5)...(6)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (13)...(14)
<223> Cationic linkage between bases

<400> 36
actcatcttt caatatctac                                             20

<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (3)...(4)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (6)...(7)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (14)...(15)
<223> Cationic linkage between bases

<400> 37
gactcatctt tcaatatcta                                             20

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (4)...(5)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (7)...(8)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (15)...(16)
<223> Cationic linkage between bases

<400> 38
agactcatct ttcaatatct                                             20

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (5)...(6)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (7)...(8)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (16)...(17)
<223> Cationic linkage between bases

<400> 39
aagactcatc tttcaatatc                                             20

<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (6)...(7)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (9)...(10)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (17)...(18)
<223> Cationic linkage between bases

<400> 40
gaagactcat ctttcaatat                                             20

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (7)...(8)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (10)...(11)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (18)...(19)
<223> Cationic linkage between bases

<400> 41
agaagactca tctttcaata                                             20

<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (8)...(9)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (11)...(12)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (19)...(20)
<223> Cationic linkage between bases

<400> 42
tagaagactc atctttcaat                                             20

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (1)...(2)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (9)...(10)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (12)...(13)
<223> Cationic linkage between bases

<400> 43
ttagaagact catctttcaa                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (2)...(3)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (10)...(11)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (13)...(14)
<223> Cationic linkage between bases

<400> 44
gttagaagac tcatctttca                                             20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (5)...(6)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (13)...(14)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (16)...(17)
<223> Cationic linkage between bases

<400> 45
tcggttagaa gactcatctt                                             20

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (7)...(8)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (15)...(16)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (18)...(19)
<223> Cationic linkage between bases

<400> 46
cctcggttag aagactcatc                                             20

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PMO antisense targeting sequence

<220> 
<221> misc_feature   
<222> (4)...(5)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (9)...(10)
<223> Cationic linkage between bases

<220> 
<221> misc_feature   
<222> (17)...(18)
<223> Cationic linkage between bases

<400> 47
gacctcggtt agaagactca                                             20

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 48
cggttagaag actcatcttt                                             20

<210> 49
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 49
cggttagaag actcatct                                               18

<210> 50
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 50
cggttagaag actcat                                                 16

<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 51
agaagactca tctttcaata                                             20

<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 52
ttagaagact catctttcaa                                             20

<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 53
ctcggttaga agactcatct                                             20

<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 54
tcaatatcta cctgcttttg                                             20

<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 55
ctttcaatat ctacctgctt                                             20

<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 56
agcaaaagca ggtagatatt                                             20

<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 57
agcaggtaga tattgaaaaa                                             20

<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 58
cattcgcttc tggtaggcct                                             20

<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 59
cccattcgct tctggtaggc                                             20

<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 60
ctcccattcg cttctggtag                                             20

<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 61
cactcccatt cgcttctggt                                             20

<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> PNA antisense targeting sequence

<400> 62
tgcactccca ttcgcttctg                                             20

<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 63
cggttagaag actcatcttt                                             20

<210> 64
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 64
gaagactcat                                                        10

<210> 65
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 65
gaagactcat                                                        10

<210> 66
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 66
gaagactcat                                                        10

<210> 67
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 67
agaagactca                                                        10

<210> 68
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 68
tagaagactc                                                        10

<210> 69
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 69
ttagaagact                                                        10

<210> 70
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 70
aagactcatc                                                        10

<210> 71
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 71
agactcatct                                                        10

<210> 72
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 72
gactcatctt                                                        10

<210> 73
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 73
actcatcttt                                                        10

<210> 74
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 74
cggttagaag actcat                                                 16

<210> 75
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 75
gttagaagac tcat                                                   14

<210> 76
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 76
gttagaagac t                                                      11

<210> 77
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 77
catctttaaa t                                                      11

<210> 78
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 78
catctttaaa tatctac                                                17

<210> 79
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 79
cggttagaag actcat                                                 16

<210> 80
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 80
ggttagaaga ctcatc                                                 16

<210> 81
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 81
gttagaagac tcatct                                                 16

<210> 82
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 82
ttagaagact catctt                                                 16

<210> 83
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 83
tagaagactc atcttt                                                 16

<210> 84
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 84
agaagactca tcttta                                                 16

<210> 85
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 85
gaagactcat ctttaa                                                 16

<210> 86
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 86
aagactcatc tttaaa                                                 16

<210> 87
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 87
agactcatct ttaaat                                                 16

<210> 88
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 88
gactcatctt taaata                                                 16

<210> 89
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 89
actcatcttt aaatat                                                 16

<210> 90
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 90
ctcatcttta aatatc                                                 16

<210> 91
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 91
tcatctttaa atatct                                                 16

<210> 92
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 92
catctttaaa tatcta                                                 16

<210> 93
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 93
atctttaaat atctac                                                 16

<210> 94
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 94
tctttaaata tctacc                                                 16

<210> 95
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 95
ctttaaatat ctacca                                                 16

<210> 96
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 96
tttaaatatc taccag                                                 16

<210> 97
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 97
cgggtagaag actcat                                                 16

<210> 98
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 98
ggttagaaga ctcatc                                                 16

<210> 99
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 99
gttagaagac tcatct                                                 16

<210> 100
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 100
ttagaagact catctt                                                 16

<210> 101
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 101
tagaagactc atcttt                                                 16

<210> 102
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 102
agaagactca tcttta                                                 16

<210> 103
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 103
gaagactcat ctttaa                                                 16

<210> 104
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 104
aagactcatc tttaaa                                                 16

<210> 105
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 105
agactcatct ttaaat                                                 16

<210> 106
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 106
gactcatctt taaata                                                 16

<210> 107
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 107
actcatcttt aaatat                                                 16

<210> 108
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 108
ctcatctata aatatc                                                 16

<210> 109
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 109
tcatctttaa atatct                                                 16

<210> 110
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 110
catctttaaa tatcta                                                 16

<210> 111
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 111
atctttaaat atctac                                                 16

<210> 112
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 112
tctttaaata tctacc                                                 16

<210> 113
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 113
ctttaaatat ctacca                                                 16

<210> 114
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> LNA antisense targeting sequence

<400> 114
tttaaatatc taccag                                                 16

<210> 115
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 115
Arg Arg Arg Gln Arg Arg Lys Lys Arg Cys
 1               5                  10  


<210> 116
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 116
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Cys
 1               5                  10          


<210> 117
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 117
Arg Arg Arg Arg Arg Phe Phe Arg Arg Arg Arg Cys
 1               5                  10          


<210> 118
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 14
<223> bAla

<400> 118
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 119
Arg Arg Arg Arg Arg Arg Arg Arg Cys
 1               5                  


<210> 120
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 120
Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys
 1               5                  10  


<210> 121
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 121
Arg Arg Arg Arg Arg Arg Arg Arg Gly
 1               5                  


<210> 122
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 122
Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly
 1               5                  10  


<210> 123
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 14, 16
<223> Acp

<220> 
<221> MOD_RES        
<222> 17
<223> bAla

<400> 123
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa
 1               5                  10                  15      
Xaa
    


<210> 124
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 8, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 5, 11, 14
<223> bAla

<400> 124
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 125
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 125
Arg Ala Arg Arg Ala Arg Arg Ala Arg Arg Ala Arg Phe Phe Cys
 1               5                  10                  15  


<210> 126
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 126
Arg Gly Arg Arg Gly Arg Arg Gly Arg Arg Gly Arg Phe Phe Cys
 1               5                  10                  15  


<210> 127
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<400> 127
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Gly
 1               5                  10          


<210> 128
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 12
<223> Acp

<220> 
<221> MOD_RES        
<222> 13
<223> bAla

<400> 128
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Xaa Xaa
 1               5                  10              


<210> 129
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide motif

<220> 
<221> VARIANT        
<222> 1, 3, 4, 7, 9, 10
<223> Xaa = Lysine, Arginine or Arginine analog

<220> 
<221> VARIANT        
<222> 2, 8
<223> Xaa = a neutral amino acid, -C(O)-(CHR)n-NH-,
      where n is 2 to 7 and R is H or methyl.

<220> 
<221> VARIANT        
<222> 5, 6, 11, 12
<223> Xaa = alpha-amino acid having a neutral aralkyl
      side chain

<400> 129
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10          


<210> 130
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide motif

<220> 
<221> VARIANT        
<222> 2, 6, 8,12
<223> Xaa = a neutral amino acid, -C(O)-(CHR)n-NH-,
      where n is 2 to 7 and R is H or methyl.
      Preferabley Acp

<400> 130
Arg Xaa Arg Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa
 1               5                  10          


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide motif

<220> 
<221> VARIANT        
<222> 3, 5, 9
<223> Xaa = a neutral amino acid, -C(O)-(CHR)n-NH-,
      where n is 2 to 7 and R is H or methyl.
      Preferabley Acp

<400> 131
Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa
 1               5                  


<210> 132
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide motif

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11
<223> Acp

<400> 132
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
 1               5                  10          


<210> 133
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arginine-rich cell penetrating peptide motif

<220> 
<221> MOD_RES        
<222> 3, 6, 9, 12
<223> Acp

<400> 133
Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa
 1               5                  10          

