                         SEQUENCE LISTING

<110>  SAPPHIRE ENERGY, INC.
       THE SCRIPPS RESEARCH INSTITUTE
       Rasala, Beth A
       Muto, Machiko
       Lee, Philip A
       Behnke, Craig A
       Mendez, Michael
       Mayfield, Stephen
       Cardoso, Rosa MF
 
<120>  PRODUCTION OF THERAPEUTIC PROTEINS IN PHOTOSYNTHETIC ORGANISMS

<130>  0808WO1

<150>  61/262826
<151>  2009-11-19

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized EPO sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (520)..(540)
<223>  TEV protease recognition site

<220>
<221>  misc_feature
<222>  (541)..(558)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (559)..(582)
<223>  TAG

<220>
<221>  misc_feature
<222>  (595)..(600)
<223>  XbaI restriction site

<400>  1
catatggtac cagctccacc tcgtttaatt tgtgactctc gtgtattaga acgttattta       60

ttagaagcaa aagaggcaga aaatattact actggttgtg cagaacattg ttcattaaat      120

gaaaacatta cagttccaga tacaaaagtt aatttttacg cttggaaacg tatggaagta      180

ggacaacaag cagtagaagt atggcaaggt ttagctttat tatcagaagc agttttaaga      240

ggtcaagcat tattagtaaa ttcatcacaa ccttgggaac cattacaatt acatgttgat      300

aaagctgttt caggtcttag atctttaact actttattac gtgctcttgg agctcaaaaa      360

gaagctattt cacctccaga cgctgcaagt gctgcacctc ttcgtacaat cactgctgat      420

acattccgta aattatttcg tgtttactca aattttcttc gtggtaaatt aaaattatat      480

actggtgaag catgtcgtac aggtgatcgt ggtaccggtg aaaacttata ctttcaaggc      540

tcaggtggcg gtggaagtga ttacaaagat gatgatgata aaggaaccgg ttaatctaga      600


<210>  2
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (173)..(179)
<223>  TEV protease recongnition site

<220>
<221>  MISC_FEATURE
<222>  (180)..(185)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (186)..(192)
<223>  TAG

<400>  2

Met Val Pro Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu 
1               5                   10                  15      


Arg Tyr Leu Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys 
            20                  25                  30          


Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys 
        35                  40                  45              


Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val 
    50                  55                  60                  


Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
65                  70                  75                  80  


Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu 
                85                  90                  95      


His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu 
            100                 105                 110         


Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala 
        115                 120                 125             


Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr 
145                 150                 155                 160 


Gly Glu Ala Cys Arg Thr Gly Asp Arg Gly Thr Gly Glu Asn Leu Tyr 
                165                 170                 175     


Phe Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
            180                 185                 190         


Lys Gly Thr Gly 
        195     


<210>  3
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 10FN3 sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (304)..(324)
<223>  TEV protease restriction site

<220>
<221>  misc_feature
<222>  (325)..(342)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (343)..(366)
<223>  TAG

<220>
<221>  misc_feature
<222>  (379)..(384)
<223>  XbaI restriction site

<400>  3
catatggtac cagtaagtga tgttccacgt gatcttgaag tagtagcagc aactccaact       60

tcattattaa tttcatggga tgcacctgct gttacagtac gttattaccg tattacttat      120

ggtgagactg gtggtaactc tccagttcaa gaatttactg ttcctggttc aaaatcaaca      180

gcaacaattt caggattaaa accaggtgtt gattatacta ttacagtata tgcagttaca      240

ggtcgtggtg attcaccagc ttcatcaaaa cctatttcaa tcaattatcg tacaggtacc      300

ggtgaaaact tatactttca aggctcaggt ggcggtggaa gtgattacaa agatgatgat      360

gataaaggaa ccggttaatc taga                                             384


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (101)..(107)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (108)..(113)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (114)..(121)
<223>  TAG

<400>  4

Met Val Pro Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala 
1               5                   10                  15      


Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val 
            20                  25                  30          


Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val 
        35                  40                  45              


Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly 
    50                  55                  60                  


Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly 
65                  70                  75                  80  


Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg 
                85                  90                  95      


Thr Gly Thr Gly Glu Asn Leu Tyr Phe Gln Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Gly 
        115                 120                 


<210>  5
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 14FN3 sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (289)..(309)
<223>  TEV protease recongnition site

<220>
<221>  misc_feature
<222>  (310)..(327)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (328)..(351)
<223>  TAG

<220>
<221>  misc_feature
<222>  (364)..(369)
<223>  XbaI restriction site

<400>  5
catatggtac caaatgttag tcctcctcgt agagctagag ttacagatgc aacagaaaca       60

acaattacaa tttcttggcg tacaaaaact gaaactatca ctggttttca agtagatgca      120

gttccagcaa atggtcaaac acctattcaa cgtacaatca aaccagacgt tagatcatat      180

actattacag gtttacaacc aggtacagat tataaaattt atttatatac attaaatgac      240

aacgctcgta gttcacctgt agttattgat gcttcaactg gtaccggtga aaacttatac      300

tttcaaggct caggtggcgg tggaagtgat tacaaagatg atgatgataa aggaaccggt      360

taatctaga                                                              369


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (96)..(102)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (103)..(108)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (109)..(116)
<223>  TAG

<400>  6

Met Val Pro Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala 
1               5                   10                  15      


Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile 
            20                  25                  30          


Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile 
        35                  40                  45              


Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu 
    50                  55                  60                  


Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn 
65                  70                  75                  80  


Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Gly Thr Gly Glu 
                85                  90                  95      


Asn Leu Tyr Phe Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
            100                 105                 110         


Asp Asp Asp Lys Gly Thr Gly 
        115                 


<210>  7
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized interferon beta sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (517)..(537)
<223>  TEV protease restriction site

<220>
<221>  misc_feature
<222>  (538)..(549)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (556)..(579)
<223>  TAG

<220>
<221>  misc_feature
<222>  (592)..(597)
<223>  XbaI restriction site

<400>  7
catatggtac catcttataa tttattagga tttttacaac gtagttctaa ctttcaatgt       60

caaaaattat tatggcaatt aaatggtcgt ttagaatact gcttaaaaga ccgtatgaat      120

tttgatattc cagaagaaat taaacaatta caacaatttc aaaaagagga tgctgcttta      180

acaatttatg aaatgttaca aaacattttt gctatttttc gtcaagattc atcatcaaca      240

ggttggaacg aaactattgt tgaaaacctt ttagcaaatg tttatcacca aatcaatcac      300

ttaaaaacag tattagaaga aaaattagaa aaagaagatt ttacaagagg taaattaatg      360

tcatcattac atttaaaacg ttattacggt cgtattttac attatttaaa agctaaagaa      420

tattcacatt gtgcttggac aattgttcgt gttgaaattc ttcgtaattt ctattttatt      480

aaccgtttaa caggatactt aagaaacggt accggtgaaa acttatactt tcaaggctca      540

ggtggcggtg gaagtgatta caaagatgat gatgataaag gaaccggtta atctaga         597


<210>  8
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (172)..(178)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (179)..(184)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (185)..(192)
<223>  TAG

<400>  8

Met Val Pro Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn 
1               5                   10                  15      


Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr 
            20                  25                  30          


Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln 
        35                  40                  45              


Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met 
    50                  55                  60                  


Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly 
65                  70                  75                  80  


Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln 
                85                  90                  95      


Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp 
            100                 105                 110         


Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr 
        115                 120                 125             


Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala 
    130                 135                 140                 


Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn 
145                 150                 155                 160 


Arg Leu Thr Gly Tyr Leu Arg Asn Gly Thr Gly Glu Asn Leu Tyr Phe 
                165                 170                 175     


Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            180                 185                 190         


Gly Thr Gly 
        195 


<210>  9
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized proinsulin sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (280)..(300)
<223>  TEV protease restriction site

<220>
<221>  misc_feature
<222>  (301)..(318)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (319)..(342)
<223>  TAG

<220>
<221>  misc_feature
<222>  (355)..(360)
<223>  XbaI restriction site

<400>  9
catatggtac catttgtaaa tcaacattta tgtggaagtc acttagttga agcattatat       60

ttagtttgtg gtgagcgtgg tttcttttat acaccaaaaa cacgtcgtga agctgaagac      120

ttacaagttg gtcaagttga gttaggagga ggacctggtg ctggttcttt acaaccttta      180

gctcttgaag gttcattaca aaaacgtggt attgttgaac aatgttgcac aagtatttgt      240

agtttatatc aattagaaaa ttattgtaac ggtaccggtg aaaacttata ctttcaaggc      300

tcaggtggcg gtggaagtga ttacaaagat gatgatgata aaggaaccgg ttaatctaga      360


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (93)..(99)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (100)..(105)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (106)..(113)
<223>  TAG

<400>  10

Met Val Pro Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu 
1               5                   10                  15      


Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  30          


Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly 
        35                  40                  45              


Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser 
    50                  55                  60                  


Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 
65                  70                  75                  80  


Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Thr Gly Glu Asn Leu Tyr 
                85                  90                  95      


Phe Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
            100                 105                 110         


Lys Gly Thr Gly 
        115     


<210>  11
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized VEGF sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (385)..(405)
<223>  TEV protease restriction site

<220>
<221>  misc_feature
<222>  (406)..(423)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (424)..(447)
<223>  TAG

<220>
<221>  misc_feature
<222>  (460)..(465)
<223>  TAG

<400>  11
catatggtac cagctccaat ggctgaaggt ggaggtcaaa accaccacga agtagtaaaa       60

tttatggacg tataccaaag atcatactgt cacccaattg aaactttagt agatattttt      120

caagaatacc ctgatgaaat tgaatatatc tttaaaccaa gttgtgttcc tcttatgcgt      180

tgtggtggat gttgtaacga tgaaggatta gaatgtgtac ctacagaaga gtcaaatatt      240

actatgcaaa ttatgagaat caaaccacat caaggtcaac acattggtga aatgagtttc      300

cttcaacata ataaatgtga atgtcgtcca aaaaaagatc gtgctagaca agaaaattgt      360

gataaacctc gtcgtggtac cggtgaaaac ttatactttc aaggctcagg tggcggtgga      420

agtgattaca aagatgatga tgataaagga accggttaat ctaga                      465


<210>  12
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (128)..(134)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (135)..(140)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (141)..(148)
<223>  TAG

<400>  12

Met Val Pro Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu 
1               5                   10                  15      


Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile 
            20                  25                  30          


Glu Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr 
        35                  40                  45              


Ile Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys 
    50                  55                  60                  


Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr 
65                  70                  75                  80  


Met Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu 
                85                  90                  95      


Met Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp 
            100                 105                 110         


Arg Ala Arg Gln Glu Asn Cys Asp Lys Pro Arg Arg Gly Thr Gly Glu 
        115                 120                 125             


Asn Leu Tyr Phe Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
    130                 135                 140                 


Asp Asp Asp Lys Gly Thr Gly 
145                 150     


<210>  13
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized HMGB1 sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  NdeI restriction site

<220>
<221>  misc_feature
<222>  (574)..(594)
<223>  TEV protease restriction site

<220>
<221>  misc_feature
<222>  (595)..(612)
<223>  LINKER

<220>
<221>  misc_feature
<222>  (613)..(636)
<223>  TAG

<220>
<221>  misc_feature
<222>  (649)..(654)
<223>  XbaI restriction site

<400>  13
catatggtac caggtaaagg agatccaaaa aaacctcgtg gtaaaatgag ttcatacgct       60

tttttcgtac aaacatgccg tgaagaacac aaaaagaaac atcctgatgc ttcagttaat      120

ttttctgaat tttctaaaaa atgttcagaa cgttggaaaa caatgagtgc taaagaaaaa      180

ggtaaattcg aagacatggc taaagcagac aaagctcgtt atgaacgtga aatgaaaact      240

tatattcctc ctaaaggcga aacaaagaaa aaatttaaag atccaaatgc tccaaaacgt      300

ccaccaagtg cttttttctt attttgttca gaatatcgtc caaaaattaa aggtgaacac      360

ccaggtttat ctattggtga tgttgctaaa aaattaggtg aaatgtggaa caatacagct      420

gctgacgata aacaacctta tgaaaaaaaa gctgctaaat taaaagagaa atacgaaaaa      480

gatattgctg cttatagagc taaaggtaaa cctgatgctg caaaaaaagg tgtagtaaaa      540

gctgaaaaat caaaaaagaa aaaaggtacc ggtgaaaact tatactttca aggctcaggt      600

ggcggtggaa gtgattacaa agatgatgat gataaaggaa ccggttaatc taga            654


<210>  14
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified protein sequence


<220>
<221>  MISC_FEATURE
<222>  (191)..(197)
<223>  TEV protease restriction site

<220>
<221>  MISC_FEATURE
<222>  (198)..(203)
<223>  LINKER

<220>
<221>  MISC_FEATURE
<222>  (204)..(211)
<223>  TAG

<400>  14

Met Val Pro Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser 
1               5                   10                  15      


Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys 
            20                  25                  30          


His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser 
        35                  40                  45              


Glu Arg Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp 
    50                  55                  60                  


Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr 
65                  70                  75                  80  


Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala 
                85                  90                  95      


Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg 
            100                 105                 110         


Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala 
        115                 120                 125             


Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln 
    130                 135                 140                 


Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp 
145                 150                 155                 160 


Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly 
                165                 170                 175     


Val Val Lys Ala Glu Lys Ser Lys Lys Lys Lys Gly Thr Gly Glu Asn 
            180                 185                 190         


Leu Tyr Phe Gln Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp 
        195                 200                 205             


Asp Asp Lys Gly Thr Gly 
    210                 


<210>  15
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized erythropoietin sequence

<400>  15
atggtaccag ctccacctcg tttaatttgt gactctcgtg tattagaacg ttatttatta       60

gaagcaaaag aggcagaaaa tattactact ggttgtgcag aacattgttc attaaatgaa      120

aacattacag ttccagatac aaaagttaat ttttacgctt ggaaacgtat ggaagtagga      180

caacaagcag tagaagtatg gcaaggttta gctttattat cagaagcagt tttaagaggt      240

caagcattat tagtaaattc atcacaacct tgggaaccat tacaattaca tgttgataaa      300

gctgtttcag gtcttagatc tttaactact ttattacgtg ctcttggagc tcaaaaagaa      360

gctatttcac ctccagacgc tgcaagtgct gcacctcttc gtacaatcac tgctgataca      420

ttccgtaaat tatttcgtgt ttactcaaat tttcttcgtg gtaaattaaa attatatact      480

ggtgaagcat gtcgtacagg tgatcgtggt accggtgaaa acttatactt tcaaggctca      540

ggtggcggtg gaagtgatta caaagatgat gatgataaag gaaccggtta a               591


<210>  16
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  17
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 10FN3 sequence

<400>  17
atggtaccag taagtgatgt tccacgtgat cttgaagtag tagcagcaac tccaacttca       60

ttattaattt catgggatgc acctgctgtt acagtacgtt attaccgtat tacttatggt      120

gagactggtg gtaactctcc agttcaagaa tttactgttc ctggttcaaa atcaacagca      180

acaatttcag gattaaaacc aggtgttgat tatactatta cagtatatgc agttacaggt      240

cgtggtgatt caccagcttc atcaaaacct atttcaatca attatcgtac aggtaccggt      300

gaaaacttat actttcaagg ctcaggtggc ggtggaagtg attacaaaga tgatgatgat      360

aaaggaaccg gttaa                                                       375


<210>  18
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  19
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 14FN3 sequence

<400>  19
atggtaccaa atgttagtcc tcctcgtaga gctagagtta cagatgcaac agaaacaaca       60

attacaattt cttggcgtac aaaaactgaa actatcactg gttttcaagt agatgcagtt      120

ccagcaaatg gtcaaacacc tattcaacgt acaatcaaac cagacgttag atcatatact      180

attacaggtt tacaaccagg tacagattat aaaatttatt tatatacatt aaatgacaac      240

gctcgtagtt cacctgtagt tattgatgct tcaactggta ccggtgaaaa cttatacttt      300

caaggctcag gtggcggtgg aagtgattac aaagatgatg atgataaagg aaccggttaa      360


<210>  20
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe 
            20                  25                  30          


Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr 
        35                  40                  45              


Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly 
    50                  55                  60                  


Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser 
65                  70                  75                  80  


Ser Pro Val Val Ile Asp Ala Ser Thr 
                85                  


<210>  21
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized interferon beta sequence

<400>  21
atggtaccat cttataattt attaggattt ttacaacgta gttctaactt tcaatgtcaa       60

aaattattat ggcaattaaa tggtcgttta gaatactgct taaaagaccg tatgaatttt      120

gatattccag aagaaattaa acaattacaa caatttcaaa aagaggatgc tgctttaaca      180

atttatgaaa tgttacaaaa catttttgct atttttcgtc aagattcatc atcaacaggt      240

tggaacgaaa ctattgttga aaacctttta gcaaatgttt atcaccaaat caatcactta      300

aaaacagtat tagaagaaaa attagaaaaa gaagatttta caagaggtaa attaatgtca      360

tcattacatt taaaacgtta ttacggtcgt attttacatt atttaaaagc taaagaatat      420

tcacattgtg cttggacaat tgttcgtgtt gaaattcttc gtaatttcta ttttattaac      480

cgtttaacag gatacttaag aaacggtacc ggtgaaaact tatactttca aggctcaggt      540

ggcggtggaa gtgattacaa agatgatgat gataaaggaa ccggttaa                   588


<210>  22
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Cys Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Arg Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Val Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Arg Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Arg Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Asp Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Val Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  23
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized proinsulin sequence

<400>  23
atggtaccat ttgtaaatca acatttatgt ggaagtcact tagttgaagc attatattta       60

gtttgtggtg agcgtggttt cttttataca ccaaaaacac gtcgtgaagc tgaagactta      120

caagttggtc aagttgagtt aggaggagga cctggtgctg gttctttaca acctttagct      180

cttgaaggtt cattacaaaa acgtggtatt gttgaacaat gttgcacaag tatttgtagt      240

ttatatcaat tagaaaatta ttgtaacggt accggtgaaa acttatactt tcaaggctca      300

ggtggcggtg gaagtgatta caaagatgat gatgataaag gaaccggtta a               351


<210>  24
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  25
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized VEGF sequence

<400>  25
atggtaccag ctccaatggc tgaaggtgga ggtcaaaacc accacgaagt agtaaaattt       60

atggacgtat accaaagatc atactgtcac ccaattgaaa ctttagtaga tatttttcaa      120

gaataccctg atgaaattga atatatcttt aaaccaagtt gtgttcctct tatgcgttgt      180

ggtggatgtt gtaacgatga aggattagaa tgtgtaccta cagaagagtc aaatattact      240

atgcaaatta tgagaatcaa accacatcaa ggtcaacaca ttggtgaaat gagtttcctt      300

caacataata aatgtgaatg tcgtccaaaa aaagatcgtg ctagacaaga aaattgtgat      360

aaacctcgtc gtggtaccgg tgaaaactta tactttcaag gctcaggtgg cggtggaagt      420

gattacaaag atgatgatga taaaggaacc ggttaa                                456


<210>  26
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  27
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized HMGB1 sequence

<400>  27
atggtaccag gtaaaggaga tccaaaaaaa cctcgtggta aaatgagttc atacgctttt       60

ttcgtacaaa catgccgtga agaacacaaa aagaaacatc ctgatgcttc agttaatttt      120

tctgaatttt ctaaaaaatg ttcagaacgt tggaaaacaa tgagtgctaa agaaaaaggt      180

aaattcgaag acatggctaa agcagacaaa gctcgttatg aacgtgaaat gaaaacttat      240

attcctccta aaggcgaaac aaagaaaaaa tttaaagatc caaatgctcc aaaacgtcca      300

ccaagtgctt ttttcttatt ttgttcagaa tatcgtccaa aaattaaagg tgaacaccca      360

ggtttatcta ttggtgatgt tgctaaaaaa ttaggtgaaa tgtggaacaa tacagctgct      420

gacgataaac aaccttatga aaaaaaagct gctaaattaa aagagaaata cgaaaaagat      480

attgctgctt atagagctaa aggtaaacct gatgctgcaa aaaaaggtgt agtaaaagct      540

gaaaaatcaa aaaagaaaaa aggtaccggt gaaaacttat actttcaagg ctcaggtggc      600

ggtggaagtg attacaaaga tgatgatgat aaaggaaccg gttaa                      645


<210>  28
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  29
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  29
ggaaggggag gacgtaggta cataaa                                            26


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  30
ttagaacgtg ttttgttccc aat                                               23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  31
cccataaata gtttcaattg g                                                 21


<210>  32
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  32
cggtggttat tccaggccaa acttatg                                           27


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  33
ccgaactgag gttgggttta                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  34
gggggagcga ataggattag                                                   20


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for psbA promoter

<400>  35
gtgctaggta actaacgttt gattttt                                           27


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for atpA promoter

<400>  36
caagggtgaa ccattacttt tg                                                22


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for EPO

<400>  37
ggttcccaag gttgtgatga                                                   20


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for 10FN3

<400>  38
ggttttgatg aagctgctgg tgaa                                              24


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for 14FN3

<400>  39
accggtacca gttgaagcat                                                   20


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for interferon beta

<400>  40
cgttccaccc tgttgatga                                                    19


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for proinsulin

<400>  41
ccggtaccgt tacaataatc                                                   20


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for VEGF

<400>  42
tgttgacctt gatgtggttt g                                                 21


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for HMGB1

<400>  43
gcatttggat ctttaaattt tt                                                22


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for EPO

<400>  44
tacgcttgga aacgtatgga                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for EPO

<400>  45
tgagctccaa gagcacgtaa                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for 10FN3

<400>  46
aatttcatgg gatgcacctg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for 10FN3

<400>  47
tcaccacgac ctgtaactgc                                                   20


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for 14FN3

<400>  48
ccaaatgtta gtcctcctcg t                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for 14FN3

<400>  49
cgtctggttt gattgtacgt tg                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for interferon beta

<400>  50
ttatggcaat taaatggtcg tt                                                22


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for interferon beta

<400>  51
tcgttccaac ctgttgatga                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for proinsulin

<400>  52
acacgtcgtg aagctgaaga                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for proinsulin

<400>  53
ttcaccggta ccgttacaat                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for VEGF

<400>  54
aggtcaaaac caccacgaag                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for VEGF

<400>  55
catccaccac aacgcataag                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for HMGB1

<400>  56
cgttggaaaa caatgagtgc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for HMGB1

<400>  57
acttggtgga cgttttggag                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR Primer for Rbcl

<400>  58
agcaggtgct ggattcaaag                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR Primer for Rbcl

<400>  59
cagctacagc agcaccacat                                                   20


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAG

<400>  60

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINKER

<400>  61

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAG

<400>  62

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  63
<211>  544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified atpA promoter/5' UTR

<400>  63
ggatcccatt tttataactg gtctcaaaat acctataaac ccattgttct tctcttttag       60

ctctaagaac aatcaattta taaatatatt tattattatg ctataatata aatactatat      120

aaatacattt acctttttat aaatacattt accttttttt taatttgcat gattttaatg      180

cttatgctat cttttttatt tagtccataa aacctttaaa ggaccttttc ttatgggata      240

tttatatttt cctaacaaag caatcggcgt cataaacttt agttgcttac gacgcctgtg      300

gacgtccccc ccttcccctt acgggcaagt aaacttaggg attttaatgc aataaataaa      360

tttgtcctct tcgggcaaat gaattttagt atttaaatat gacaagggtg aaccattact      420

tttgttaaca agtgatctta ccactcacta tttttgttga attttaaact tatttaaaat      480

tctcgagaaa gattttaaaa ataaactttt ttaatctttt atttattttt tcttttttca      540

tatg                                                                   544


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LINKER

<400>  64
tcaggtggcg gtggaagt                                                     18


<210>  65
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified psbD promoter/5' UTR

<400>  65
ggatccatga aattaaatgg atatttggta catttaattc cacaaaaatg tccaatactt       60

aaaatacaaa attaaaagta ttagttgtaa acttgactaa cattttaaat tttaaatttt      120

ttcctaatta tatattttac ttgcaaaatt tataaaaatt ttatgcattt ttatatcata      180

ataataaaac ctttattcat ggtttataat ataataattg tgatgactat gcacaaagca      240

gttctagtcc catatatata actatatata acccgtttaa agatttattt aaaaatatgt      300

gtgtaaaaaa tgcttatttt taattttatt ttatataagt tataatatta aatacacaat      360

gattaaaatt aaataataat aaatttaacg taacgatgag ttgttttttt attttggaga      420

tacacgcata tg                                                          432


<210>  66
<211>  392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified psbA 3' UTR

<400>  66
tctagactta gcttcaacta actctagctc aaacaactaa ttttttttta aactaaaata       60

aatctggtta accatacctg gtttatttta gtttatacac acttttcata tatatatact      120

taatagctac cataggcagt tggcaggacg tccccttacg ggacaaatgt atttattgtt      180

gcctgccaac tgcctaatat aaatattagt ggacgtcccc ttccccttac gggcaagtaa      240

acttagggat tttaatgctc cgttaggagg caaataaatt ttagtggcag ttgcctcgcc      300

tatcggctaa caagttcctt cggagtatat aaatatcctg ccaactgccg atatttatat      360

actaggcagt ggcggtacca ctcgacggat cc                                    392


<210>  67
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified rbcL 3' UTR

<400>  67
tctagagtcg acctgcaggc atgcaagctt gtactcaagc tcgtaacgaa ggtcgtgacc       60

ttgctcgtga aggtggcgac gtaattcgtt cagcttgtaa atggtctcca gaacttgctg      120

ctgcatgtga agtttggaaa gaaattaaat tcgaatttga tactattgac aaactttaat      180

ttttattttt catgatgttt atgtgaatag cataaacatc gtttttattt tttatggtgt      240

ttaggttaaa tacctaaaca tcattttaca tttttaaaat taagttctaa agttatcttt      300

tgtttaaatt tgcctgtgct ttataaatta cgatgtgcca gaaaaataaa atcttagctt      360

tttattatag aatttatctt tatgtattat attttataag taataaaaga aatagtaaca      420

tacgtcgacg gatcc                                                       435


<210>  68
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  68
atgggggtgc acgaatgtcc tgcctggctg tggcttctcc tgtccctgct gtcgctccct       60

ctgggcctcc cagtcctggg cgccccacca cgcctcatct gtgacagccg agtcctggag      120

aggtacctct tggaggccaa ggaggccgag aatatcacga cgggctgtgc tgaacactgc      180

agcttgaatg agaatatcac tgtcccagac accaaagtta atttctatgc ctggaagagg      240

atggaggtcg ggcagcaggc cgtagaagtc tggcagggcc tggccctgct gtcggaagct      300

gtcctgcggg gccaggccct gttggtcaac tcttcccagc cgtgggagcc cctgcagctg      360

catgtggata aagccgtcag tggccttcgc agcctcacca ctctgcttcg ggctctggga      420

gcccagaagg aagccatctc ccctccagat gcggcctcag ctgctccact ccgaacaatc      480

actgctgaca ctttccgcaa actcttccga gtctactcca atttcctccg gggaaagctg      540

aagctgtaca caggggaggc ctgcaggaca ggggacagat ga                         582


<210>  69
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  69
gtttctgatg ttccgaggga cctggaagtt gttgctgcga cccccaccag cctactgatc       60

agctgggatg ctcctgctgt cacagtgaga tattacagga tcacttacgg agagacagga      120

ggaaatagcc ctgtccagga gttcactgtg cctgggagca agtctacagc taccatcagc      180

ggccttaaac ctggagttga ttataccatc actgtgtatg ctgtcactgg ccgtggagac      240

agccccgcaa gcagcaagcc aatttccatt aattaccgaa ca                         282


<210>  70
<211>  267
<212>  DNA
<213>  Homo sapiens

<400>  70
aatgtcagcc caccaagaag ggctcgtgtg acagatgcta ctgagaccac catcaccatt       60

agctggagaa ccaagactga gacgatcact ggcttccaag ttgatgccgt tccagccaat      120

ggccagactc caatccagag aaccatcaag ccagatgtca gaagctacac catcacaggt      180

ttacaaccag gcactgacta caagatctac ctgtacacct tgaatgacaa tgctcggagc      240

tcccctgtgg tcatcgacgc ctccact                                          267


<210>  71
<211>  564
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaccaaca agtgtctcct ccaaattgct ctcctgttgt gcttctccac gacagctctt       60

tccatgagct acaacttgct tggattccta caaagaagca gcaattgtca gtgtcagaag      120

ctcctgtggc aattgaatgg gaggcttgaa tactgcctca aggacaggag gaactttgac      180

atccctgagg agattaagca gctgcagcag ttccagaagg aggacgccgc agtgaccatc      240

tatgagatgc tccagaacat ctttgctatt ttcagacaag attcatcgag cactggctgg      300

aatgagacta ttgttgagaa cctcctggct aatgtctatc atcagagaaa ccatctgaag      360

acagtcctgg aagaaaaact ggagaaagaa gatttcacca ggggaaaacg catgagcagt      420

ctgcacctga aaagatatta tgggaggatt ctgcattacc tgaaggccaa ggaggacagt      480

cactgtgcct ggaccatagt cagagtggaa atcctaagga acttttacgt cattaacaga      540

cttacaggtt acctccgaaa ctga                                             564


<210>  72
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  72
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg tgcggctcac acctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccaaga cccgccggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtccctgca gaagcgtggc attgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  73
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  73
atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat       60

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      120

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      180

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      240

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      300

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      360

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      420

aaatgtgaca agccgaggcg gtga                                             444


<210>  74
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  74
atgggcaaag gagatcctaa gaagccgaga ggcaaaatgt catcatatgc attttttgtg       60

caaacttgtc gggaggagca taagaagaag cacccagatg cttcagtcaa cttctcagag      120

ttttctaaga agtgctcaga gaggtggaag accatgtctg ctaaagagaa aggaaaattt      180

gaagatatgg caaaagcgga caaggcccgt tatgaaagag aaatgaaaac ctatatccct      240

cccaaagggg agacaaaaaa gaagttcaag gatcccaatg cacccaagag gcctccttcg      300

gccttcttcc tcttctgctc tgagtatcgc ccaaaaatca aaggagaaca tcctggcctg      360

tccattggtg atgttgcgaa gaaactggga gagatgtgga ataacactgc tgcagatgac      420

aagcagcctt atgaaaagaa ggctgcgaag ctgaaggaaa aatacgaaaa ggatattgct      480

gcatatcgag ctaaaggaaa gcctgatgca gcaaaaaagg gagttgtcaa ggctgaaaaa      540

agcaagaaaa agaaggaaga ggaggaagat gaggaagatg aagaggatga ggaggaggag      600

gaagatgaag aagatgaaga tgaagaagaa gatgatgatg atgaataa                   648


<210>  75
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized aphA6 gene

<400>  75
atggaattgc ccaatattat tcaacaattt atcggaaaca gcgttttaga gccaaataaa       60

attggtcagt cgccatcgga tgtttattct tttaatcgaa ataatgaaac tttttttctt      120

aagcgatcta gcactttata tacagagacc acatacagtg tctctcgtga agcgaaaatg      180

ttgagttggc tctctgagaa attaaaggtg cctgaactca tcatgacttt tcaggatgag      240

cagtttgaat ttatgatcac taaagcgatc aatgcaaaac caatttcagc gcttttttta      300

acagaccaag aattgcttgc tatctataag gaggcactca atctgttaaa ttcaattgct      360

attattgatt gtccatttat ttcaaacatt gatcatcggt taaaagagtc aaaatttttt      420

attgataacc aactccttga cgatatagat caagatgatt ttgacactga attatgggga      480

gaccataaaa cttacctaag tctatggaat gagttaaccg agactcgtgt tgaagaaaga      540

ttggtttttt ctcatggcga tatcacggat agtaatattt ttatagataa attcaatgaa      600

atttattttt tagaccttgg tcgtgctggg ttagcagatg aatttgtaga tatatccttt      660

gttgaacgtt gcctaagaga ggatgcatcg gaggaaactg cgaaaatatt tttaaagcat      720

ttaaaaaatg atagacctga caaaaggaat tattttttaa aacttgatga attgaattga      780


<210>  76
<211>  259
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  76

Met Glu Leu Pro Asn Ile Ile Gln Gln Phe Ile Gly Asn Ser Val Leu 
1               5                   10                  15      


Glu Pro Asn Lys Ile Gly Gln Ser Pro Ser Asp Val Tyr Ser Phe Asn 
            20                  25                  30          


Arg Asn Asn Glu Thr Phe Phe Leu Lys Arg Ser Ser Thr Leu Tyr Thr 
        35                  40                  45              


Glu Thr Thr Tyr Ser Val Ser Arg Glu Ala Lys Met Leu Ser Trp Leu 
    50                  55                  60                  


Ser Glu Lys Leu Lys Val Pro Glu Leu Ile Met Thr Phe Gln Asp Glu 
65                  70                  75                  80  


Gln Phe Glu Phe Met Ile Thr Lys Ala Ile Asn Ala Lys Pro Ile Ser 
                85                  90                  95      


Ala Leu Phe Leu Thr Asp Gln Glu Leu Leu Ala Ile Tyr Lys Glu Ala 
            100                 105                 110         


Leu Asn Leu Leu Asn Ser Ile Ala Ile Ile Asp Cys Pro Phe Ile Ser 
        115                 120                 125             


Asn Ile Asp His Arg Leu Lys Glu Ser Lys Phe Phe Ile Asp Asn Gln 
    130                 135                 140                 


Leu Leu Asp Asp Ile Asp Gln Asp Asp Phe Asp Thr Glu Leu Trp Gly 
145                 150                 155                 160 


Asp His Lys Thr Tyr Leu Ser Leu Trp Asn Glu Leu Thr Glu Thr Arg 
                165                 170                 175     


Val Glu Glu Arg Leu Val Phe Ser His Gly Asp Ile Thr Asp Ser Asn 
            180                 185                 190         


Ile Phe Ile Asp Lys Phe Asn Glu Ile Tyr Phe Leu Asp Leu Gly Arg 
        195                 200                 205             


Ala Gly Leu Ala Asp Glu Phe Val Asp Ile Ser Phe Val Glu Arg Cys 
    210                 215                 220                 


Leu Arg Glu Asp Ala Ser Glu Glu Thr Ala Lys Ile Phe Leu Lys His 
225                 230                 235                 240 


Leu Lys Asn Asp Arg Pro Asp Lys Arg Asn Tyr Phe Leu Lys Leu Asp 
                245                 250                 255     


Glu Leu Asn 
            


<210>  77
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  77

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  78
<211>  215
<212>  PRT
<213>  Rattus norvegicus

<400>  78

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  79
<211>  215
<212>  PRT
<213>  Canis lupus familiaris

<400>  79

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  80
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized EPO sequence

<400>  80
gctccacctc gtttaatttg tgactctcgt gtattagaac gttatttatt agaagcaaaa       60

gaggcagaaa atattactac tggttgtgca gaacattgtt cattaaatga aaacattaca      120

gttccagata caaaagttaa tttttacgct tggaaacgta tggaagtagg acaacaagca      180

gtagaagtat ggcaaggttt agctttatta tcagaagcag ttttaagagg tcaagcatta      240

ttagtaaatt catcacaacc ttgggaacca ttacaattac atgttgataa agctgtttca      300

ggtcttagat ctttaactac tttattacgt gctcttggag ctcaaaaaga agctatttca      360

cctccagacg ctgcaagtgc tgcacctctt cgtacaatca ctgctgatac attccgtaaa      420

ttatttcgtg tttactcaaa ttttcttcgt ggtaaattaa aattatatac tggtgaagca      480

tgtcgtacag gtgatcgt                                                    498


<210>  81
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  82
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 10FN3 sequence

<400>  82
gtaagtgatg ttccacgtga tcttgaagta gtagcagcaa ctccaacttc attattaatt       60

tcatgggatg cacctgctgt tacagtacgt tattaccgta ttacttatgg tgagactggt      120

ggtaactctc cagttcaaga atttactgtt cctggttcaa aatcaacagc aacaatttca      180

ggattaaaac caggtgttga ttatactatt acagtatatg cagttacagg tcgtggtgat      240

tcaccagctt catcaaaacc tatttcaatc aattatcgta ca                         282


<210>  83
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized 14FN3 sequence

<400>  83
aatgttagtc ctcctcgtag agctagagtt acagatgcaa cagaaacaac aattacaatt       60

tcttggcgta caaaaactga aactatcact ggttttcaag tagatgcagt tccagcaaat      120

ggtcaaacac ctattcaacg tacaatcaaa ccagacgtta gatcatatac tattacaggt      180

ttacaaccag gtacagatta taaaatttat ttatatacat taaatgacaa cgctcgtagt      240

tcacctgtag ttattgatgc ttcaact                                          267


<210>  84
<211>  495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized interferon beta sequence

<400>  84
tcttataatt tattaggatt tttacaacgt agttctaact ttcaatgtca aaaattatta       60

tggcaattaa atggtcgttt agaatactgc ttaaaagacc gtatgaattt tgatattcca      120

gaagaaatta aacaattaca acaatttcaa aaagaggatg ctgctttaac aatttatgaa      180

atgttacaaa acatttttgc tatttttcgt caagattcat catcaacagg ttggaacgaa      240

actattgttg aaaacctttt agcaaatgtt tatcaccaaa tcaatcactt aaaaacagta      300

ttagaagaaa aattagaaaa agaagatttt acaagaggta aattaatgtc atcattacat      360

ttaaaacgtt attacggtcg tattttacat tatttaaaag ctaaagaata ttcacattgt      420

gcttggacaa ttgttcgtgt tgaaattctt cgtaatttct attttattaa ccgtttaaca      480

ggatacttaa gaaac                                                       495


<210>  85
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  85

Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Cys Gln Cys 
1               5                   10                  15      


Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu Lys 
            20                  25                  30          


Asp Arg Arg Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln Gln 
        35                  40                  45              


Phe Gln Lys Glu Asp Ala Ala Val Thr Ile Tyr Glu Met Leu Gln Asn 
    50                  55                  60                  


Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn Glu 
65                  70                  75                  80  


Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Arg Asn His 
                85                  90                  95      


Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr Arg 
            100                 105                 110         


Gly Lys Arg Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg Ile 
        115                 120                 125             


Leu His Tyr Leu Lys Ala Lys Glu Asp Ser His Cys Ala Trp Thr Ile 
    130                 135                 140                 


Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Val Ile Asn Arg Leu Thr 
145                 150                 155                 160 


Gly Tyr Leu Arg Asn 
                165 


<210>  86
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized proinsulin sequence

<400>  86
tttgtaaatc aacatttatg tggaagtcac ttagttgaag cattatattt agtttgtggt       60

gagcgtggtt tcttttatac accaaaaaca cgtcgtgaag ctgaagactt acaagttggt      120

caagttgagt taggaggagg acctggtgct ggttctttac aacctttagc tcttgaaggt      180

tcattacaaa aacgtggtat tgttgaacaa tgttgcacaa gtatttgtag tttatatcaa      240

ttagaaaatt attgtaac                                                    258


<210>  87
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  87

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  88
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized VEGF sequence

<400>  88
gctccaatgg ctgaaggtgg aggtcaaaac caccacgaag tagtaaaatt tatggacgta       60

taccaaagat catactgtca cccaattgaa actttagtag atatttttca agaataccct      120

gatgaaattg aatatatctt taaaccaagt tgtgttcctc ttatgcgttg tggtggatgt      180

tgtaacgatg aaggattaga atgtgtacct acagaagagt caaatattac tatgcaaatt      240

atgagaatca aaccacatca aggtcaacac attggtgaaa tgagtttcct tcaacataat      300

aaatgtgaat gtcgtccaaa aaaagatcgt gctagacaag aaaattgtga taaacctcgt      360

cgt                                                                    363


<210>  89
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  89

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Lys Cys Asp Lys Pro Arg Arg 
        115                 120     


<210>  90
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized HMGB1 sequence

<400>  90
ggtaaaggag atccaaaaaa acctcgtggt aaaatgagtt catacgcttt tttcgtacaa       60

acatgccgtg aagaacacaa aaagaaacat cctgatgctt cagttaattt ttctgaattt      120

tctaaaaaat gttcagaacg ttggaaaaca atgagtgcta aagaaaaagg taaattcgaa      180

gacatggcta aagcagacaa agctcgttat gaacgtgaaa tgaaaactta tattcctcct      240

aaaggcgaaa caaagaaaaa atttaaagat ccaaatgctc caaaacgtcc accaagtgct      300

tttttcttat tttgttcaga atatcgtcca aaaattaaag gtgaacaccc aggtttatct      360

attggtgatg ttgctaaaaa attaggtgaa atgtggaaca atacagctgc tgacgataaa      420

caaccttatg aaaaaaaagc tgctaaatta aaagagaaat acgaaaaaga tattgctgct      480

tatagagcta aaggtaaacc tgatgctgca aaaaaaggtg tagtaaaagc tgaaaaatca      540

aaaaagaaaa aa                                                          552


<210>  91
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  91

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
1               5                   10                  15      


Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
            20                  25                  30          


Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
        35                  40                  45              


Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
    50                  55                  60                  


Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
65                  70                  75                  80  


Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                85                  90                  95      


Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
            100                 105                 110         


Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
        115                 120                 125             


Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
    130                 135                 140                 


Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
145                 150                 155                 160 


Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                165                 170                 175     


Ala Glu Lys Ser Lys Lys Lys Lys 
            180                 


<210>  92
<211>  1477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified Chlamydomonas reinhardtii sequence

<400>  92
gaattccata tttagataaa cgatttcaag cagcagaatt agctttatta gaacaaactt       60

gtaaagaaat gaatgtacca atgccgcgca ttgtagaaaa accagataat tattatcaaa      120

ttcgacgtat acgtgaatta aaacctgatt taacgattac tggaatggca catgcaaatc      180

cattagaagc tcgaggtatt acaacaaaat ggtcagttga atttactttt gctcaaattc      240

atggatttac taatacacgt gaaattttag aattagtaac acagcctctt agacgcaatc      300

taatgtcaaa tcaatctgta aatgctattt cttaatataa atcccaaaag atttttttta      360

taatactgag acttcaacac ttacttgttt ttattttttg tagttacaat tcactcacgt      420

taaagacatt ggaaaatgag gcaggacgtt agtcgatatt tatacactct taagtttact      480

tgcccaatat ttatattagg acgtcccctt cgggtaaata aattttagtg gcagtggtac      540

caccactgcc tattttaata ctccgaagca tataaatata cttcggagta tataaatatc      600

cactaatatt tatattaggc agttggcagg caacaataaa taaatttgtc ccgtaagggg      660

acgtcccgaa ggggaagggg aagaaggcag ttgcctcgcc tatcggctaa caagttcctt      720

tggagtatat aaccgcctac aggtaactta aagaacattt gttacccgta ggggtttata      780

cttctaattg cttcttctga acaataaaat ggtttgtgtg gtctgggcta ggaaacttgt      840

aacaatgtgt agtgtcgctt ccgcttccct tcgggacgtc cccttcgggt aagtaaactt      900

aggagtatta aatcgggacg tccccttcgg gtaaataaat ttcagtggac gtccccttac      960

gggacgccag tagacgtcag tggcagttgc ctcgcctatc ggctaacaag ttccttcgga     1020

gtatataaat atagaatgtt tacatactcc taagtttact tgcctccttc ggagtatata     1080

aatatcccga aggggaagga ggacgccagt ggcagtggta ccgccactgc ctgcttcctc     1140

cttcggagta tgtaaacccc ttcgggcaac taaagtttat cgcagtatat aaatataggc     1200

agttggcagg caactgccac tgacgtccta ttttaatact ccgaaggagg cagttggcag     1260

gcaactgcca ctgacgtccc gtaagggtaa ggggacgtcc actggcgtcc cgtaagggga     1320

aggggacgta ggtacataaa tgtgctaggt aactaacgtt tgattttttg tggtataata     1380

tatgtaccat gcttttaata gaagcttgaa tttataaatt aaaatatttt tacaatattt     1440

tacggagaaa ttaaaacttt aaaaaaatta acatatg                              1477


