                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Yang, Jie
       Zhang, Xiyun
       Andor, Attila
 
<120>  Recombinant Beta-Glucosidase Variants for Production of Soluble 
       Sugars from Cellulosic Biomass

<130>  026501-002020PC

<140>  WO PCT/US2010/058098
<141>  2010-11-24

<150>  US 61/264,608
<151>  2009-11-25

<150>  US 61/355,511
<151>  2010-06-16

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  2613
<212>  DNA
<213>  Myceliophthora thermophila

<400>  1
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta ccagcaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg caggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacacccagt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gaccgacgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cgggagattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggt cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcccgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaagacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa tggtgcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacggcccag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tctaccagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  2
<211>  870
<212>  PRT
<213>  Myceliophthora thermophila

<400>  2

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Gln Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Gln Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Gln Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Asp Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Glu Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Ser Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Lys Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Gly Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ala Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Tyr Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  3
<211>  2556
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  3
atagaaagta gaaaggtaca tcaaaaacca ttagctagat cagaaccatt ctacccttct       60

ccatggatga accctaatgc agatggatgg gcagaagcat atgctcaggc caagagtttt      120

gtctcccaga tgactctgtt ggaaaaggtt aatctgacaa caggagtagg atggggtgca      180

gaacagtgtg tcggccaagt tggtgctatc cctagattgg gtcttagaag tttgtgtatg      240

cacgattctc ccttaggtat aagaggcgct gactataact cagcattccc atccgggcaa      300

actgttgctg cgacatggga caggggtttg atgtatagaa ggggttatgc gatgggtcaa      360

gaggcaaagg gtaaaggaat taatgtattg ttggggccgg tggcggggcc actgggaaga      420

atgccagaag gtggaaggaa ctgggaagga ttcgcccccg acccagtgct aacaggtata      480

ggtatgtccg aaacgatcaa aggcatacaa gatgcaggtg ttatcgcctg tgcgaagcat      540

tttattggta atgaacaaga gcattttcgt caagtgccag aggctcaagg ttatggttat      600

aatatttctg aaactttaag ttccaacatc gatgacaaaa ccatgcacga gttatactta      660

tggccttttg cagacgctgt gagagctggc gttggctctg ttatgtgctc ttatcagcaa      720

gttaataact cttacgcctg tcaaaattcc aagttactaa atgacttatt gaagaacgaa      780

ctaggattcc aaggattcgt catgagcgat tggcaagcac agcatactgg tgctgcatcc      840

gctgtggcag gattagatat gtcaatgcca ggagatacac aatttaatac tggcgttagt      900

ttttggggtg caaacctaac tttagctgtt ctaaacggta cggtacctgc atatcgttta      960

gacgacatgg ccatgcgtat aatggctgct ttattcaaag ttacaaaaac caccgattta     1020

gaaccaatta attttagttt ttggacagat gacacatatg gtcctataca ctgggctgct     1080

aagcaagggt accaagaaat aaatagtcac gttgacgtaa gagcggatca cggcaatctt     1140

atcagagaga tagcagcaaa gggaactgta ttgttgaaga atactggttc attaccacta     1200

aacaaaccaa agtttgtcgc agtcattggt gaagatgctg gttcatcccc taatggacca     1260

aatggttgta gtgacagagg ctgcaatgaa ggcacgttgg caatgggctg gggctcaggg     1320

actgccaatt acccctattt ggtctctccg gatgcggctt tacaggctag agcaatccag     1380

gatggtacta gatacgagag cgtcctaagt aactatgccg aagaaaagac taaggcctta     1440

gtcagtcaag ccaatgccac tgctatcgtt ttcgtaaacg cggattctgg cgaaggttat     1500

atcaatgttg atggtaatga aggtgacaga aagaatttaa ctttatggaa taacggcgac     1560

acattagtta aaaatgtatc aagttggtgt tccaatacta tcgtcgtgat acattctgtt     1620

ggtccagttt tactgacaga ctggtacgat aacccaaaca ttaccgccat tttatgggca     1680

ggtctgccag ggcaggaatc aggaaattcc attacggacg tactatacgg aaaggttaac     1740

ccagccgcca ggagcccttt cacatggggt aagacaagag agagctacgg agctgatgtt     1800

ctttataaac cgaacaacgg gaatggagcg ccacagcaag attttactga aggtgtgttc     1860

attgactata gatacttcga caaagttgac gatgactcag ttatatatga attcggtcac     1920

ggtctatctt atactacttt tgaatattca aatataagag tagtcaaaag taatgtttct     1980

gaatataggc cgaccaccgg aacgacggct caagcgccta ccttcggtaa tttttcaacg     2040

gatttagaag attatttatt tcccaaagac gaatttccat acatctacca atacatatac     2100

ccctatctga atactaccga tccaagaaga gcttctgccg atccacatta cgggcagact     2160

gccgaagagt tcttgccacc acacgctact gacgacgatc ctcaacctct tctgaggtcc     2220

agtggcggaa attcacctgg tggtaatagg cagctgtatg atattgtgta tactataacg     2280

gctgatatta ctaatactgg tagcgttgtt ggtgaagaag tgccgcaatt atatgtgtct     2340

ttaggtggtc cggaagatcc taaggttcag ttaagagact ttgataggat gagaatagaa     2400

cctggagaaa ctaggcaatt tacaggtaga ttgacccgta gggatctgtc aaactgggat     2460

gtaacagtgc aagattgggt aatcagcagg tacccgaaaa ctgcatacgt gggtagatct     2520

tcccgtaagt tagatttgaa aattgaattg ccataa                               2556


<210>  4
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  4
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta ccagcaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacacccagt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gaccctggac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggt cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcccgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaagacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa tggtgcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacggcccag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tctaccagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  5
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  5

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Gln Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Gln Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Leu Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Ser Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Lys Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Gly Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ala Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Tyr Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  6
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  6
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc agttgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacggcccag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tctaccagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  7
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  7

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Leu Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ala Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Tyr Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  8
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  8
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc agttgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  9
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  9

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Leu Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  10
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  10
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgaa gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc agttgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacggcccag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctaccca     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagaaaa ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  11
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  11

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Leu Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ala Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Lys Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  12
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  12
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccga cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcgtgcg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccagggc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgc tgaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcgggcgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  13
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  13

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Val Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Gly Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Leu Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Gly Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  14
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  14
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccat tggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcatccg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccaggtc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgt tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatgtgca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc agttgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcaa aacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcggccgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  15
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  15

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Ile Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Phe Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Cys Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Leu Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Lys Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  16
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  16
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccat cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggaggag      240

cagtgcgtcg gcaacgtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcgtgcg aggaaccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccagggc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgg tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatgtgca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcgggcgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  17
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  17

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Ile Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Glu Glu 
65                  70                  75                  80  


Gln Cys Val Gly Asn Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Val Arg Gly Thr Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Gly Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Val Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Cys Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Gly Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  18
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  18
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccat cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg gggggctgag      240

cagtgcgtcg gcaacgtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcgtgcg aggaagcgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccagggc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgg tcaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatgtgca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcgggcgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  19
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  19

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Ile Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu 
65                  70                  75                  80  


Gln Cys Val Gly Asn Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Val Arg Gly Ser Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Gly Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Val Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Cys Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Gly Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  20
<211>  2613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA

<400>  20
atgaaggctg ctgcgctttc ctgcctcttc ggcagtaccc ttgccgttgc aggcgccatt       60

gaatcgagaa aggttcacca gaagcccctc gcgagatctg aaccttttta cccgtcgcca      120

tggatgaatc ccaacgccat cggctgggcg gaggcctatg cccaggccaa gtcctttgtc      180

tcccaaatga ctctgctaga gaaggtcaac ttgaccacgg gagtcggctg ggggatggag      240

cagtgcgtcg gccaagtggg cgcgatccct cgccttggac ttcgcagtct gtgcatgcat      300

gactcccctc tcggcgtgcg aggagccgac tacaactcag cgttcccctc tggccagacc      360

gttgctgcta cctgggatcg cggtctgatg taccgtcgcg gctacgcaat gggccaggag      420

gccaaaggca agggcatcaa tgtccttctc ggaccagtcg ccggccccct tggccgcatg      480

cccgagggcg gtcgtaactg ggaaggcttc gctccggatc ccgtccttac cggcatcggc      540

atgtccgaga cgatcaaggg cattcaggat gctggcgtca tcgcttgtgc gaagcacttt      600

attggaaacg agcaggagca cttcagacag gtgccagaag cccagggata cggttacaac      660

atcagcgaaa ccctctcctc caacattgac gacaagacca tgcacgagct ctacctttgg      720

ccgtttgccg atgccgtccg ggccggcgtc ggctctgtca tgtgctcgta caaccagggc      780

aacaactcgt acgcctgcca gaactcgaag ctgctgaacg acctcctcaa gaacgagctt      840

gggtttcagg gcttcgtcat gagcgactgg tgggcacagc acactggcgc agcaagcgcc      900

gtggctggtc tcgatatgtc catgccgggc gacaccatgc tgaacactgg cgtcagtttc      960

tggggcgcca atctcaccct cgccgtcctc aacggcacag tccctgccta ccgtctcgac     1020

gacatggcca tgcgcatcat ggccgccctc ttcaaggtca ccaagaccac cgacctggaa     1080

ccgatcaact tctccttctg gacccgcgac acttatggcc cgatccactg ggccgccaag     1140

cagggctacc aggagattaa ttcccacgtt gacgtccgcg ccgaccacgg caacctcatc     1200

cggaacattg ccgccaaggg tacggtgctg ctgaagaata ccggctctct acccctgaac     1260

aagccaaagt tcgtggccgt catcggcgag gatgctgggc cgagccccaa cgggcccaac     1320

ggctgcagcg accgcggctg taacgaaggc acgctcgcca tgggctgggg atccggcaca     1380

gccaactatc cgtacctcgt ttcccccgac gccgcgctcc aggcgcgggc catccaggac     1440

ggcacgaggt acgagagcgt cctgtccaac tacgccgagg aaaatacaaa ggctctggtc     1500

tcgcaggcca atgcaaccgc catcgtcttc gtcaatgccg actcaggcga gggctacatc     1560

aacgtggacg gtaacgaggg cgaccgtaag aacctgactc tctggaacaa cggtgatact     1620

ctggtcaaga acgtctcgag ctggtgcagc aacaccatcg tcgtcatcca ctcggtcggc     1680

ccggtcctcc tgaccgattg gtacgacaac cccaacatca cggccattct ctgggctggt     1740

cttccgggcc aggagtcggg caactccatc accgacgtgc tttacggcaa ggtcaacccc     1800

gccgcccgct cgcccttcac ttggggcaag acccgcgaaa gctatggcgc ggacgtcctg     1860

tacaagccga ataatggcaa ttgggcgccc caacaggact tcaccgaggg cgtcttcatc     1920

gactaccgct acttcgacaa ggttgacgat gactcggtca tctacgagtt cggccacggc     1980

ctgagctaca ccaccttcga gtacagcaac atccgcgtcg tcaagtccaa cgtcagcgag     2040

taccggccca cgacgggcac cacgattcag gccccgacgt ttggcaactt ctccaccgac     2100

ctcgaggact atctcttccc caaggacgag ttcccctaca tcccgcagta catctacccg     2160

tacctcaaca cgaccgaccc ccggagggcc tcgggcgatc cccactacgg ccagaccgcc     2220

gaggagttcc tcccgcccca cgccaccgat gacgaccccc agccgctcct ccggtcctcg     2280

ggcggaaact cccccggcgg caaccgccag ctgtacgaca ttgtctacac aatcacggcc     2340

gacatcacga atacgggctc cgttgtaggc gaggaggtac cgcagctcta cgtctcgctg     2400

ggcggtcccg aggatcccaa ggtgcagctg cgcgactttg acaggatgcg gatcgaaccc     2460

ggcgagacga ggcagttcac cggccgcctg acgcgcagag atctgagcaa ctgggacgtc     2520

acggtgcagg actgggtcat cagcaggtat cccaagacgg catatgttgg gaggagcagc     2580

cggaagttgg atctcaagat tgagcttcct tga                                  2613


<210>  21
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  21

Met Lys Ala Ala Ala Leu Ser Cys Leu Phe Gly Ser Thr Leu Ala Val 
1               5                   10                  15      


Ala Gly Ala Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg 
            20                  25                  30          


Ser Glu Pro Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Ile Gly 
        35                  40                  45              


Trp Ala Glu Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr 
    50                  55                  60                  


Leu Leu Glu Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Met Glu 
65                  70                  75                  80  


Gln Cys Val Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser 
                85                  90                  95      


Leu Cys Met His Asp Ser Pro Leu Gly Val Arg Gly Ala Asp Tyr Asn 
            100                 105                 110         


Ser Ala Phe Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly 
        115                 120                 125             


Leu Met Tyr Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys 
    130                 135                 140                 


Gly Ile Asn Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met 
145                 150                 155                 160 


Pro Glu Gly Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu 
                165                 170                 175     


Thr Gly Ile Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly 
            180                 185                 190         


Val Ile Ala Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe 
        195                 200                 205             


Arg Gln Val Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr 
    210                 215                 220                 


Leu Ser Ser Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp 
225                 230                 235                 240 


Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser 
                245                 250                 255     


Tyr Asn Gln Gly Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu 
            260                 265                 270         


Asn Asp Leu Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser 
        275                 280                 285             


Asp Trp Trp Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu 
    290                 295                 300                 


Asp Met Ser Met Pro Gly Asp Thr Met Leu Asn Thr Gly Val Ser Phe 
305                 310                 315                 320 


Trp Gly Ala Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala 
                325                 330                 335     


Tyr Arg Leu Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys 
            340                 345                 350         


Val Thr Lys Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr 
        355                 360                 365             


Arg Asp Thr Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln 
    370                 375                 380                 


Glu Ile Asn Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile 
385                 390                 395                 400 


Arg Asn Ile Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser 
                405                 410                 415     


Leu Pro Leu Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala 
            420                 425                 430         


Gly Pro Ser Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn 
        435                 440                 445             


Glu Gly Thr Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro 
    450                 455                 460                 


Tyr Leu Val Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp 
465                 470                 475                 480 


Gly Thr Arg Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Asn Thr 
                485                 490                 495     


Lys Ala Leu Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn 
            500                 505                 510         


Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp 
        515                 520                 525             


Arg Lys Asn Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn 
    530                 535                 540                 


Val Ser Ser Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly 
545                 550                 555                 560 


Pro Val Leu Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile 
                565                 570                 575     


Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp 
            580                 585                 590         


Val Leu Tyr Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp 
        595                 600                 605             


Gly Lys Thr Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn 
    610                 615                 620                 


Asn Gly Asn Trp Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile 
625                 630                 635                 640 


Asp Tyr Arg Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu 
                645                 650                 655     


Phe Gly His Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg 
            660                 665                 670         


Val Val Lys Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr 
        675                 680                 685             


Ile Gln Ala Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr 
    690                 695                 700                 


Leu Phe Pro Lys Asp Glu Phe Pro Tyr Ile Pro Gln Tyr Ile Tyr Pro 
705                 710                 715                 720 


Tyr Leu Asn Thr Thr Asp Pro Arg Arg Ala Ser Gly Asp Pro His Tyr 
                725                 730                 735     


Gly Gln Thr Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp 
            740                 745                 750         


Pro Gln Pro Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn 
        755                 760                 765             


Arg Gln Leu Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn 
    770                 775                 780                 


Thr Gly Ser Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu 
785                 790                 795                 800 


Gly Gly Pro Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met 
                805                 810                 815     


Arg Ile Glu Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg 
            820                 825                 830         


Arg Asp Leu Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser 
        835                 840                 845             


Arg Tyr Pro Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp 
    850                 855                 860                 


Leu Lys Ile Glu Leu Pro 
865                 870 


<210>  22
<211>  851
<212>  PRT
<213>  Myceliophthora thermophila

<400>  22

Ile Glu Ser Arg Lys Val His Gln Lys Pro Leu Ala Arg Ser Glu Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Pro Trp Met Asn Pro Asn Ala Asp Gly Trp Ala Glu 
            20                  25                  30          


Ala Tyr Ala Gln Ala Lys Ser Phe Val Ser Gln Met Thr Leu Leu Glu 
        35                  40                  45              


Lys Val Asn Leu Thr Thr Gly Val Gly Trp Gly Ala Glu Gln Cys Val 
    50                  55                  60                  


Gly Gln Val Gly Ala Ile Pro Arg Leu Gly Leu Arg Ser Leu Cys Met 
65                  70                  75                  80  


His Asp Ser Pro Leu Gly Ile Arg Gly Ala Asp Tyr Asn Ser Ala Phe 
                85                  90                  95      


Pro Ser Gly Gln Thr Val Ala Ala Thr Trp Asp Arg Gly Leu Met Tyr 
            100                 105                 110         


Arg Arg Gly Tyr Ala Met Gly Gln Glu Ala Lys Gly Lys Gly Ile Asn 
        115                 120                 125             


Val Leu Leu Gly Pro Val Ala Gly Pro Leu Gly Arg Met Pro Glu Gly 
    130                 135                 140                 


Gly Arg Asn Trp Glu Gly Phe Ala Pro Asp Pro Val Leu Thr Gly Ile 
145                 150                 155                 160 


Gly Met Ser Glu Thr Ile Lys Gly Ile Gln Asp Ala Gly Val Ile Ala 
                165                 170                 175     


Cys Ala Lys His Phe Ile Gly Asn Glu Gln Glu His Phe Arg Gln Val 
            180                 185                 190         


Pro Glu Ala Gln Gly Tyr Gly Tyr Asn Ile Ser Glu Thr Leu Ser Ser 
        195                 200                 205             


Asn Ile Asp Asp Lys Thr Met His Glu Leu Tyr Leu Trp Pro Phe Ala 
    210                 215                 220                 


Asp Ala Val Arg Ala Gly Val Gly Ser Val Met Cys Ser Tyr Gln Gln 
225                 230                 235                 240 


Val Asn Asn Ser Tyr Ala Cys Gln Asn Ser Lys Leu Leu Asn Asp Leu 
                245                 250                 255     


Leu Lys Asn Glu Leu Gly Phe Gln Gly Phe Val Met Ser Asp Trp Gln 
            260                 265                 270         


Ala Gln His Thr Gly Ala Ala Ser Ala Val Ala Gly Leu Asp Met Ser 
        275                 280                 285             


Met Pro Gly Asp Thr Gln Phe Asn Thr Gly Val Ser Phe Trp Gly Ala 
    290                 295                 300                 


Asn Leu Thr Leu Ala Val Leu Asn Gly Thr Val Pro Ala Tyr Arg Leu 
305                 310                 315                 320 


Asp Asp Met Ala Met Arg Ile Met Ala Ala Leu Phe Lys Val Thr Lys 
                325                 330                 335     


Thr Thr Asp Leu Glu Pro Ile Asn Phe Ser Phe Trp Thr Asp Asp Thr 
            340                 345                 350         


Tyr Gly Pro Ile His Trp Ala Ala Lys Gln Gly Tyr Gln Glu Ile Asn 
        355                 360                 365             


Ser His Val Asp Val Arg Ala Asp His Gly Asn Leu Ile Arg Glu Ile 
    370                 375                 380                 


Ala Ala Lys Gly Thr Val Leu Leu Lys Asn Thr Gly Ser Leu Pro Leu 
385                 390                 395                 400 


Asn Lys Pro Lys Phe Val Ala Val Ile Gly Glu Asp Ala Gly Ser Ser 
                405                 410                 415     


Pro Asn Gly Pro Asn Gly Cys Ser Asp Arg Gly Cys Asn Glu Gly Thr 
            420                 425                 430         


Leu Ala Met Gly Trp Gly Ser Gly Thr Ala Asn Tyr Pro Tyr Leu Val 
        435                 440                 445             


Ser Pro Asp Ala Ala Leu Gln Ala Arg Ala Ile Gln Asp Gly Thr Arg 
    450                 455                 460                 


Tyr Glu Ser Val Leu Ser Asn Tyr Ala Glu Glu Lys Thr Lys Ala Leu 
465                 470                 475                 480 


Val Ser Gln Ala Asn Ala Thr Ala Ile Val Phe Val Asn Ala Asp Ser 
                485                 490                 495     


Gly Glu Gly Tyr Ile Asn Val Asp Gly Asn Glu Gly Asp Arg Lys Asn 
            500                 505                 510         


Leu Thr Leu Trp Asn Asn Gly Asp Thr Leu Val Lys Asn Val Ser Ser 
        515                 520                 525             


Trp Cys Ser Asn Thr Ile Val Val Ile His Ser Val Gly Pro Val Leu 
    530                 535                 540                 


Leu Thr Asp Trp Tyr Asp Asn Pro Asn Ile Thr Ala Ile Leu Trp Ala 
545                 550                 555                 560 


Gly Leu Pro Gly Gln Glu Ser Gly Asn Ser Ile Thr Asp Val Leu Tyr 
                565                 570                 575     


Gly Lys Val Asn Pro Ala Ala Arg Ser Pro Phe Thr Trp Gly Lys Thr 
            580                 585                 590         


Arg Glu Ser Tyr Gly Ala Asp Val Leu Tyr Lys Pro Asn Asn Gly Asn 
        595                 600                 605             


Gly Ala Pro Gln Gln Asp Phe Thr Glu Gly Val Phe Ile Asp Tyr Arg 
    610                 615                 620                 


Tyr Phe Asp Lys Val Asp Asp Asp Ser Val Ile Tyr Glu Phe Gly His 
625                 630                 635                 640 


Gly Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asn Ile Arg Val Val Lys 
                645                 650                 655     


Ser Asn Val Ser Glu Tyr Arg Pro Thr Thr Gly Thr Thr Ala Gln Ala 
            660                 665                 670         


Pro Thr Phe Gly Asn Phe Ser Thr Asp Leu Glu Asp Tyr Leu Phe Pro 
        675                 680                 685             


Lys Asp Glu Phe Pro Tyr Ile Tyr Gln Tyr Ile Tyr Pro Tyr Leu Asn 
    690                 695                 700                 


Thr Thr Asp Pro Arg Arg Ala Ser Ala Asp Pro His Tyr Gly Gln Thr 
705                 710                 715                 720 


Ala Glu Glu Phe Leu Pro Pro His Ala Thr Asp Asp Asp Pro Gln Pro 
                725                 730                 735     


Leu Leu Arg Ser Ser Gly Gly Asn Ser Pro Gly Gly Asn Arg Gln Leu 
            740                 745                 750         


Tyr Asp Ile Val Tyr Thr Ile Thr Ala Asp Ile Thr Asn Thr Gly Ser 
        755                 760                 765             


Val Val Gly Glu Glu Val Pro Gln Leu Tyr Val Ser Leu Gly Gly Pro 
    770                 775                 780                 


Glu Asp Pro Lys Val Gln Leu Arg Asp Phe Asp Arg Met Arg Ile Glu 
785                 790                 795                 800 


Pro Gly Glu Thr Arg Gln Phe Thr Gly Arg Leu Thr Arg Arg Asp Leu 
                805                 810                 815     


Ser Asn Trp Asp Val Thr Val Gln Asp Trp Val Ile Ser Arg Tyr Pro 
            820                 825                 830         


Lys Thr Ala Tyr Val Gly Arg Ser Ser Arg Lys Leu Asp Leu Lys Ile 
        835                 840                 845             


Glu Leu Pro 
    850     


