                         SEQUENCE LISTING

<110>  The Rockefeller University
       MacKinnon, Roderick
 
<120>  Methods for Identifying Compounds That Modulate Ion Channel 
       Activity of a Kir Channel

<130>  20210.0002P1

<141>  2010-11-30

<150>  61/283317
<151>  2009-12-01

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Glu Phe His Pro Ser Ala Asn His Thr Pro 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro 
1               5                   10      


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala Ser Lys Glu Gly Lys Ala 
1               5               


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Ala Glu Gly Arg Gly Arg Thr Pro 
1               5                   10  


<210>  5
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Ala Ser Pro Gly Val Pro Ala Ala Gly Gly Pro Ala Ala Gly Gly 
1               5                   10                  15      


Gly Gly Ala Ala Pro Val Ala Pro Lys Pro 
            20                  25      


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ala Pro Pro Pro Pro Ala Pro 
1               5               


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Asn Lys Ala His Val Gly Asn Tyr Thr Pro 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp His Val Gly Asp Gln Glu Trp Ile Pro 
1               5                   10  


<210>  9
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys Ser Gly Leu Glu Ser 
1               5                   10                  15      


Thr Val 
        


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Pro Ser Glu Gly Thr Ala Glu Pro 
1               5                   


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Leu Asp His Asp Ala Pro Pro Glu Asn His Thr Ile 
1               5                   10              


<210>  12
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  12

Glu Asn Gln Glu Asn Asn Lys Pro 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Gallus gallus

<400>  13

Glu Asn Pro Gly Gly Asp Asp Thr Phe Lys Pro 
1               5                   10      


<210>  14
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu 
1               5                   10                  15      


Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe 
            20                  25                  30          


Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg 
        35                  40                  45              


Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe 
    50                  55                  60                  


Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
65                  70                  75                  80  


Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly 
                85                  90                  95      


Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe 
            100                 105                 110         


His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu 
        115                 120                 125             


Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
    130                 135                 140                 


Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
145                 150                 155                 160 


Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                165                 170                 175     


Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
            180                 185                 190         


Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
        195                 200                 205             


Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
    210                 215                 220                 


His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu 
225                 230                 235                 240 


Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly 
                245                 250                 255     


Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile 
            260                 265                 270         


Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln 
        275                 280                 285             


Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
    290                 295                 300                 


Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
305                 310                 315                 320 


Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                325                 330                 335     


Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr 
            340                 345                 350         


Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg 
        355                 360                 365             


Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn 
    370                 375                 380                 


Glu Thr Asp Asp Thr Lys Met 
385                 390     


<210>  15
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Ser Val Ala Lys Val Tyr Tyr Ser Gln Thr Thr Gln Thr Glu 
1               5                   10                  15      


Ser Arg Pro Leu Met Gly Pro Gly Ile Arg Arg Arg Arg Val Leu Thr 
            20                  25                  30          


Lys Asp Gly Arg Ser Asn Val Arg Met Glu His Ile Ala Asp Lys Arg 
        35                  40                  45              


Phe Leu Tyr Leu Lys Asp Leu Trp Thr Thr Phe Ile Asp Met Gln Trp 
    50                  55                  60                  


Arg Tyr Lys Leu Leu Leu Phe Ser Ala Thr Phe Ala Gly Thr Trp Phe 
65                  70                  75                  80  


Leu Phe Gly Val Val Trp Tyr Leu Val Ala Val Ala His Gly Asp Leu 
                85                  90                  95      


Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro Cys Val Val Gln Val 
            100                 105                 110         


His Thr Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr 
        115                 120                 125             


Ile Gly Tyr Gly Phe Arg Tyr Ile Ser Glu Glu Cys Pro Leu Ala Ile 
    130                 135                 140                 


Val Leu Leu Ile Ala Gln Leu Val Leu Thr Thr Ile Leu Glu Ile Phe 
145                 150                 155                 160 


Ile Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala 
                165                 170                 175     


Glu Thr Ile Arg Phe Ser Gln His Ala Val Val Ala Ser His Asn Gly 
            180                 185                 190         


Lys Pro Cys Leu Met Ile Arg Val Ala Asn Met Arg Lys Ser Leu Leu 
        195                 200                 205             


Ile Gly Cys Gln Val Thr Gly Lys Leu Leu Gln Thr His Gln Thr Lys 
    210                 215                 220                 


Glu Gly Glu Asn Ile Arg Leu Asn Gln Val Asn Val Thr Phe Gln Val 
225                 230                 235                 240 


Asp Thr Ala Ser Asp Ser Pro Phe Leu Ile Leu Pro Leu Thr Phe Tyr 
                245                 250                 255     


His Val Val Asp Glu Thr Ser Pro Leu Lys Asp Leu Pro Leu Arg Ser 
            260                 265                 270         


Gly Glu Gly Asp Phe Glu Leu Val Leu Ile Leu Ser Gly Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Leu Pro Glu Glu 
    290                 295                 300                 


Ile Leu Trp Gly Tyr Glu Phe Thr Pro Ala Ile Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Gly Lys Tyr Ile Ala Asp Phe Ser Leu Phe Asp Gln Val Val Lys Val 
                325                 330                 335     


Ala Ser Pro Ser Gly Leu Arg Asp Ser Thr Val Arg Tyr Gly Asp Pro 
            340                 345                 350         


Glu Lys Leu Lys Leu Glu Glu Ser Leu Arg Glu Gln Ala Glu Lys Glu 
        355                 360                 365             


Gly Ser Ala Leu Ser Val Arg Ile Ser Asn Val 
    370                 375                 


<210>  16
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210>  17
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Ala Ala Ser Arg Ala Asn Pro Tyr Ser Ile Val Ser Ser Glu 
1               5                   10                  15      


Glu Asp Gly Leu His Leu Val Thr Met Ser Gly Ala Asn Gly Phe Gly 
            20                  25                  30          


Asn Gly Lys Val His Thr Arg Arg Arg Cys Arg Asn Arg Phe Val Lys 
        35                  40                  45              


Lys Asn Gly Gln Cys Asn Ile Glu Phe Ala Asn Met Asp Glu Lys Ser 
    50                  55                  60                  


Gln Arg Tyr Leu Ala Asp Met Phe Thr Thr Cys Val Asp Ile Arg Trp 
65                  70                  75                  80  


Arg Tyr Met Leu Leu Ile Phe Ser Leu Ala Phe Leu Ala Ser Trp Leu 
                85                  90                  95      


Leu Phe Gly Ile Ile Phe Trp Val Ile Ala Val Ala His Gly Asp Leu 
            100                 105                 110         


Glu Pro Ala Glu Gly Arg Gly Arg Thr Pro Cys Val Met Gln Val His 
        115                 120                 125             


Gly Phe Met Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Leu Arg Cys Val Thr Glu Glu Cys Pro Val Ala Val Phe 
145                 150                 155                 160 


Met Val Val Ala Gln Ser Ile Val Gly Cys Ile Ile Asp Ser Phe Met 
                165                 170                 175     


Ile Gly Ala Ile Met Ala Lys Met Ala Arg Pro Lys Lys Arg Ala Gln 
            180                 185                 190         


Thr Leu Leu Phe Ser His Asn Ala Val Val Ala Leu Arg Asp Gly Lys 
        195                 200                 205             


Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Ile Val 
    210                 215                 220                 


Glu Ala His Val Arg Ala Gln Leu Ile Lys Pro Arg Val Thr Glu Glu 
225                 230                 235                 240 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asp Val Gly Phe Asp 
                245                 250                 255     


Lys Gly Leu Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Leu His 
            260                 265                 270         


Glu Ile Asp Glu Ala Ser Pro Leu Phe Gly Ile Ser Arg Gln Asp Leu 
        275                 280                 285             


Glu Thr Asp Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu 
    290                 295                 300                 


Ala Thr Ala Met Thr Thr Gln Ala Arg Ser Ser Tyr Leu Ala Asn Glu 
305                 310                 315                 320 


Ile Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe Glu Glu Lys Asn 
                325                 330                 335     


Gln Tyr Lys Ile Asp Tyr Ser His Phe His Lys Thr Tyr Glu Val Pro 
            340                 345                 350         


Ser Thr Pro Arg Cys Ser Ala Lys Asp Leu Val Glu Asn Lys Phe Leu 
        355                 360                 365             


Leu Pro Ser Ala Asn Ser Phe Cys Tyr Glu Asn Glu Leu Ala Phe Leu 
    370                 375                 380                 


Ser Arg Asp Glu Glu Asp Glu Ala Asp Gly Asp Gln Asp Gly Arg Ser 
385                 390                 395                 400 


Arg Asp Gly Leu Ser Pro Gln Ala Arg His Asp Phe Asp Arg Leu Gln 
                405                 410                 415     


Ala Gly Gly Gly Val Leu Glu Gln Arg Pro Tyr Arg Arg Glu Ser Glu 
            420                 425                 430         


Ile 
    


<210>  18
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  18

Met His Gly His Ser Arg Asn Gly Gln Ala His Val Pro Arg Arg Lys 
1               5                   10                  15      


Arg Arg Asn Arg Phe Val Lys Lys Asn Gly Gln Cys Asn Val Tyr Phe 
            20                  25                  30          


Ala Asn Leu Ser Asn Lys Ser Gln Arg Tyr Met Ala Asp Ile Phe Thr 
        35                  40                  45              


Thr Cys Val Asp Thr Arg Trp Arg Tyr Met Leu Met Ile Phe Ser Ala 
    50                  55                  60                  


Ala Phe Leu Val Ser Trp Leu Phe Phe Gly Leu Leu Phe Trp Cys Ile 
65                  70                  75                  80  


Ala Phe Phe His Gly Asp Leu Glu Ala Ser Pro Gly Val Pro Ala Ala 
                85                  90                  95      


Gly Gly Pro Ala Ala Gly Gly Gly Gly Ala Ala Pro Val Ala Pro Lys 
            100                 105                 110         


Pro Cys Ile Met His Val Asn Gly Phe Leu Gly Ala Phe Leu Phe Ser 
        115                 120                 125             


Val Glu Thr Gln Thr Thr Ile Gly Tyr Gly Phe Arg Cys Val Thr Glu 
    130                 135                 140                 


Glu Cys Pro Leu Ala Val Ile Ala Val Val Val Gln Ser Ile Val Gly 
145                 150                 155                 160 


Cys Val Ile Asp Ser Phe Met Ile Gly Thr Ile Met Ala Lys Met Ala 
                165                 170                 175     


Arg Pro Lys Lys Arg Ala Gln Thr Leu Leu Phe Ser His His Ala Val 
            180                 185                 190         


Ile Ser Val Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Val Gly Asn 
        195                 200                 205             


Leu Arg Lys Ser His Ile Val Glu Ala His Val Arg Ala Gln Leu Ile 
    210                 215                 220                 


Lys Pro Tyr Met Thr Gln Glu Gly Glu Tyr Leu Pro Leu Asp Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Val Gly Tyr Asp Ile Gly Leu Asp Arg Ile Phe Leu Val 
                245                 250                 255     


Ser Pro Ile Ile Ile Val His Glu Ile Asp Glu Asp Ser Pro Leu Tyr 
            260                 265                 270         


Gly Met Gly Lys Glu Glu Leu Glu Ser Glu Asp Phe Glu Ile Val Val 
        275                 280                 285             


Ile Leu Glu Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Ala Arg 
    290                 295                 300                 


Ser Ser Tyr Leu Ala Ser Glu Ile Leu Trp Gly His Arg Phe Glu Pro 
305                 310                 315                 320 


Val Val Phe Glu Glu Lys Ser His Tyr Lys Val Asp Tyr Ser Arg Phe 
                325                 330                 335     


His Lys Thr Tyr Glu Val Ala Gly Thr Pro Cys Cys Ser Ala Arg Glu 
            340                 345                 350         


Leu Gln Glu Ser Lys Ile Thr Val Leu Pro Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Ser Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Met Ser Gln Glu Glu 
    370                 375                 380                 


Glu Glu Met Glu Glu Glu Ala Ala Ala Ala Ala Ala Val Ala Ala Gly 
385                 390                 395                 400 


Leu Gly Leu Glu Ala Gly Ser Lys Glu Glu Ala Gly Ile Ile Arg Met 
                405                 410                 415     


Leu Glu Phe Gly Ser His Leu Asp Leu Glu Arg Met Gln Ala Ser Leu 
            420                 425                 430         


Pro Leu Asp Asn Ile Ser Tyr Arg Arg Glu Ser Ala Ile 
        435                 440                 445 


<210>  19
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Leu Ala Arg Ala Leu Arg Arg Leu Ser Gly Ala Leu Asp Ser 
1               5                   10                  15      


Gly Asp Ser Arg Ala Gly Asp Glu Glu Glu Ala Gly Pro Gly Leu Cys 
            20                  25                  30          


Arg Asn Gly Trp Ala Pro Ala Pro Val Gln Ser Pro Val Gly Arg Arg 
        35                  40                  45              


Arg Gly Arg Phe Val Lys Lys Asp Gly His Cys Asn Val Arg Phe Val 
    50                  55                  60                  


Asn Leu Gly Gly Gln Gly Ala Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Cys Val Asp Val Arg Trp Arg Trp Met Cys Leu Leu Phe Ser Cys Ser 
                85                  90                  95      


Phe Leu Ala Ser Trp Leu Leu Phe Gly Leu Ala Phe Trp Leu Ile Ala 
            100                 105                 110         


Ser Leu His Gly Asp Leu Ala Ala Pro Pro Pro Pro Ala Pro Cys Phe 
        115                 120                 125             


Ser His Val Ala Ser Phe Leu Ala Ala Phe Leu Phe Ala Leu Glu Thr 
    130                 135                 140                 


Gln Thr Ser Ile Gly Tyr Gly Val Arg Ser Val Thr Glu Glu Cys Pro 
145                 150                 155                 160 


Ala Ala Val Ala Ala Val Val Leu Gln Cys Ile Ala Gly Cys Val Leu 
                165                 170                 175     


Asp Ala Phe Val Val Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys 
            180                 185                 190         


Lys Arg Asn Glu Thr Leu Val Phe Ser Glu Asn Ala Val Val Ala Leu 
        195                 200                 205             


Arg Asp His Arg Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Arg 
    210                 215                 220                 


Ser His Leu Val Glu Ala His Val Arg Ala Gln Leu Leu Gln Pro Arg 
225                 230                 235                 240 


Val Thr Pro Glu Gly Glu Tyr Ile Pro Leu Asp His Gln Asp Val Asp 
                245                 250                 255     


Val Gly Phe Asp Gly Gly Thr Asp Arg Ile Phe Leu Val Ser Pro Ile 
            260                 265                 270         


Thr Ile Val His Glu Ile Asp Ser Ala Ser Pro Leu Tyr Glu Leu Gly 
        275                 280                 285             


Arg Ala Glu Leu Ala Arg Ala Asp Phe Glu Leu Val Val Ile Leu Glu 
    290                 295                 300                 


Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr 
305                 310                 315                 320 


Leu Pro Gly Glu Leu Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe 
                325                 330                 335     


Gln Arg Gly Ser Gln Tyr Glu Val Asp Tyr Arg His Phe His Arg Thr 
            340                 345                 350         


Tyr Glu Val Pro Gly Thr Pro Val Cys Ser Ala Lys Glu Leu Asp Glu 
        355                 360                 365             


Arg Ala Glu Gln Ala Ser His Ser Leu Lys Ser Ser Phe Pro Gly Ser 
    370                 375                 380                 


Leu Thr Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Ser Cys Cys Gln 
385                 390                 395                 400 


Glu Glu Asp Glu Asp Asp Glu Thr Glu Glu Gly Asn Gly Val Glu Thr 
                405                 410                 415     


Glu Asp Gly Ala Ala Ser Pro Arg Val Leu Thr Pro Thr Leu Ala Leu 
            420                 425                 430         


Thr Leu Pro Pro 
        435     


<210>  20
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Ala Leu Arg Arg Lys Phe Gly Asp Asp Tyr Gln Val Val Thr 
1               5                   10                  15      


Thr Ser Ser Ser Gly Ser Gly Leu Gln Pro Gln Gly Pro Gly Gln Asp 
            20                  25                  30          


Pro Gln Gln Gln Leu Val Pro Lys Lys Lys Arg Gln Arg Phe Val Asp 
        35                  40                  45              


Lys Asn Gly Arg Cys Asn Val Gln His Gly Asn Leu Gly Ser Glu Thr 
    50                  55                  60                  


Ser Arg Tyr Leu Ser Asp Leu Phe Thr Thr Leu Val Asp Leu Lys Trp 
65                  70                  75                  80  


Arg Trp Asn Leu Phe Ile Phe Ile Leu Thr Tyr Thr Val Ala Trp Leu 
                85                  90                  95      


Phe Met Ala Ser Met Trp Trp Val Ile Ala Tyr Thr Arg Gly Asp Leu 
            100                 105                 110         


Asn Lys Ala His Val Gly Asn Tyr Thr Pro Cys Val Ala Asn Val Tyr 
        115                 120                 125             


Asn Phe Pro Ser Ala Phe Leu Phe Phe Ile Glu Thr Glu Ala Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Tyr Arg Tyr Ile Thr Asp Lys Cys Pro Glu Gly Ile Ile 
145                 150                 155                 160 


Leu Phe Leu Phe Gln Ser Ile Leu Gly Ser Ile Val Asp Ala Phe Leu 
                165                 170                 175     


Ile Gly Cys Met Phe Ile Lys Met Ser Gln Pro Lys Lys Arg Ala Glu 
            180                 185                 190         


Thr Leu Met Phe Ser Glu His Ala Val Ile Ser Met Arg Asp Gly Lys 
        195                 200                 205             


Leu Thr Leu Met Phe Arg Val Gly Asn Leu Arg Asn Ser His Met Val 
    210                 215                 220                 


Ser Ala Gln Ile Arg Cys Lys Leu Leu Lys Ser Arg Gln Thr Pro Glu 
225                 230                 235                 240 


Gly Glu Phe Leu Pro Leu Asp Gln Leu Glu Leu Asp Val Gly Phe Ser 
                245                 250                 255     


Thr Gly Ala Asp Gln Leu Phe Leu Val Ser Pro Leu Thr Ile Cys His 
            260                 265                 270         


Val Ile Asp Ala Lys Ser Pro Phe Tyr Asp Leu Ser Gln Arg Ser Met 
        275                 280                 285             


Gln Thr Glu Gln Phe Glu Ile Val Val Ile Leu Glu Gly Ile Val Glu 
    290                 295                 300                 


Thr Thr Gly Met Thr Cys Gln Ala Arg Thr Ser Tyr Thr Glu Asp Glu 
305                 310                 315                 320 


Val Leu Trp Gly His Arg Phe Phe Pro Val Ile Ser Leu Glu Glu Gly 
                325                 330                 335     


Phe Phe Lys Val Asp Tyr Ser Gln Phe His Ala Thr Phe Glu Val Pro 
            340                 345                 350         


Thr Pro Pro Tyr Ser Val Lys Glu Gln Glu Glu Met Leu Leu Met Ser 
        355                 360                 365             


Ser Pro Leu Ile Ala Pro Ala Ile Thr Asn Ser Lys Glu Arg His Asn 
    370                 375                 380                 


Ser Val Glu Cys Leu Asp Gly Leu Asp Asp Ile Thr Thr Lys Leu Pro 
385                 390                 395                 400 


Ser Lys Leu Gln Lys Ile Thr Gly Arg Glu Asp Phe Pro Lys Lys Leu 
                405                 410                 415     


Leu Arg Met Ser Ser Thr Thr Ser Glu Lys Ala Tyr Ser Leu Gly Asp 
            420                 425                 430         


Leu Pro Met Lys Leu Gln Arg Ile Ser Ser Val Pro Gly Asn Ser Glu 
        435                 440                 445             


Glu Lys Leu Val Ser Lys Thr Thr Lys Met Leu Ser Asp Pro Met Ser 
    450                 455                 460                 


Gln Ser Val Ala Asp Leu Pro Pro Lys Leu Gln Lys Met Ala Gly Gly 
465                 470                 475                 480 


Ala Ala Arg Met Glu Gly Asn Leu Pro Ala Lys Leu Arg Lys Met Asn 
                485                 490                 495     


Ser Asp Arg Phe Thr 
            500     


<210>  21
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Gly Asp Ser Arg Asn Ala Met Asn Gln Asp Met Glu Ile Gly 
1               5                   10                  15      


Val Thr Pro Trp Asp Pro Lys Lys Ile Pro Lys Gln Ala Arg Asp Tyr 
            20                  25                  30          


Val Pro Ile Ala Thr Asp Arg Thr Arg Leu Leu Ala Glu Gly Lys Lys 
        35                  40                  45              


Pro Arg Gln Arg Tyr Met Glu Lys Ser Gly Lys Cys Asn Val His His 
    50                  55                  60                  


Gly Asn Val Gln Glu Thr Tyr Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Val Phe Thr Met Val 
                85                  90                  95      


Tyr Thr Val Thr Trp Leu Phe Phe Gly Phe Ile Trp Trp Leu Ile Ala 
            100                 105                 110         


Tyr Ile Arg Gly Asp Leu Asp His Val Gly Asp Gln Glu Trp Ile Pro 
        115                 120                 125             


Cys Val Glu Asn Leu Ser Gly Phe Val Ser Ala Phe Leu Phe Ser Ile 
    130                 135                 140                 


Glu Thr Glu Thr Thr Ile Gly Tyr Gly Phe Arg Val Ile Thr Glu Lys 
145                 150                 155                 160 


Cys Pro Glu Gly Ile Ile Leu Leu Leu Val Gln Ala Ile Leu Gly Ser 
                165                 170                 175     


Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys Ile Ser Gln 
            180                 185                 190         


Pro Lys Lys Arg Ala Glu Thr Leu Met Phe Ser Asn Asn Ala Val Ile 
        195                 200                 205             


Ser Met Arg Asp Glu Lys Leu Cys Leu Met Phe Arg Val Gly Asp Leu 
    210                 215                 220                 


Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys Leu Ile Lys 
225                 230                 235                 240 


Ser Arg Gln Thr Lys Glu Gly Glu Phe Ile Pro Leu Asn Gln Thr Asp 
                245                 250                 255     


Ile Asn Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe Leu Val Ser 
            260                 265                 270         


Pro Leu Ile Ile Ser His Glu Ile Asn Gln Lys Ser Pro Phe Trp Glu 
        275                 280                 285             


Met Ser Gln Ala Gln Leu His Gln Glu Glu Phe Glu Val Val Val Ile 
    290                 295                 300                 


Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln Ala Arg Ser 
305                 310                 315                 320 


Ser Tyr Met Asp Thr Glu Val Leu Trp Gly His Arg Phe Thr Pro Val 
                325                 330                 335     


Leu Thr Leu Glu Lys Gly Phe Tyr Glu Val Asp Tyr Asn Thr Phe His 
            340                 345                 350         


Asp Thr Tyr Glu Thr Asn Thr Pro Ser Cys Cys Ala Lys Glu Leu Ala 
        355                 360                 365             


Glu Met Lys Arg Glu Gly Arg Leu Leu Gln Tyr Leu Pro Ser Pro Pro 
    370                 375                 380                 


Leu Leu Gly Gly Cys Ala Glu Ala Gly Leu Asp Ala Glu Ala Glu Gln 
385                 390                 395                 400 


Asn Glu Glu Asp Glu Pro Lys Gly Leu Gly Gly Ser Arg Glu Ala Arg 
                405                 410                 415     


Gly Ser Val 
            


<210>  22
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Ser Val Ala Lys Val Tyr Tyr Ser Gln Thr Thr Gln Thr Glu 
1               5                   10                  15      


Ser Arg Pro Leu Met Gly Pro Gly Ile Arg Arg Arg Arg Val Leu Thr 
            20                  25                  30          


Lys Asp Gly Arg Ser Asn Val Arg Met Glu His Ile Ala Asp Lys Arg 
        35                  40                  45              


Phe Leu Tyr Leu Lys Asp Leu Trp Thr Thr Phe Ile Asp Met Gln Trp 
    50                  55                  60                  


Arg Tyr Lys Leu Leu Leu Phe Ser Ala Thr Phe Ala Gly Thr Trp Phe 
65                  70                  75                  80  


Leu Phe Gly Val Val Trp Tyr Leu Val Ala Val Ala His Gly Asp Leu 
                85                  90                  95      


Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro Cys Val Val Gln Val 
            100                 105                 110         


His Thr Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr 
        115                 120                 125             


Ile Gly Tyr Gly Phe Arg Tyr Ile Ser Glu Glu Cys Pro Leu Ala Ile 
    130                 135                 140                 


Val Leu Leu Ile Ala Gln Leu Val Leu Thr Thr Ile Leu Glu Ile Phe 
145                 150                 155                 160 


Ile Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala 
                165                 170                 175     


Glu Thr Ile Arg Phe Ser Gln His Ala Val Val Ala Ser His Asn Gly 
            180                 185                 190         


Lys Pro Cys Leu Met Ile Arg Val Ala Asn Met Arg Lys Ser Leu Leu 
        195                 200                 205             


Ile Gly Cys Gln Val Thr Gly Lys Leu Leu Gln Thr His Gln Thr Lys 
    210                 215                 220                 


Glu Gly Glu Asn Ile Arg Leu Asn Gln Val Asn Val Thr Phe Gln Val 
225                 230                 235                 240 


Asp Thr Ala Ser Asp Ser Pro Phe Leu Ile Leu Pro Leu Thr Phe Tyr 
                245                 250                 255     


His Val Val Asp Glu Thr Ser Pro Leu Lys Asp Leu Pro Leu Arg Ser 
            260                 265                 270         


Gly Glu Gly Asp Phe Glu Leu Val Leu Ile Leu Ser Gly Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Leu Pro Glu Glu 
    290                 295                 300                 


Ile Leu Trp Gly Tyr Glu Phe Thr Pro Ala Ile Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Gly Lys Tyr Ile Ala Asp Phe Ser Leu Phe Asp Gln Val Val Lys Val 
                325                 330                 335     


Ala Ser Pro Ser Gly Leu Arg Asp Ser Thr Val Arg Tyr Gly Asp Pro 
            340                 345                 350         


Glu Lys Leu Lys Leu Glu Glu Ser Leu Arg Glu Gln Ala Glu Lys Glu 
        355                 360                 365             


Gly Ser Ala Leu Ser Val Arg Ile Ser Asn Val 
    370                 375                 


<210>  23
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  24
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  25
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Ala Arg Lys Ser Ile Ile Pro Glu Glu Tyr Val Leu Ala Arg 
1               5                   10                  15      


Ile Ala Ala Glu Asn Leu Arg Lys Pro Arg Ile Arg Asp Arg Leu Pro 
            20                  25                  30          


Lys Ala Arg Phe Ile Ala Lys Ser Gly Ala Cys Asn Leu Ala His Lys 
        35                  40                  45              


Asn Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Ile Phe Thr Thr Leu 
    50                  55                  60                  


Val Asp Leu Lys Trp Arg His Thr Leu Val Ile Phe Thr Met Ser Phe 
65                  70                  75                  80  


Leu Cys Ser Trp Leu Leu Phe Ala Ile Met Trp Trp Leu Val Ala Phe 
                85                  90                  95      


Ala His Gly Asp Ile Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys 
            100                 105                 110         


Ser Gly Leu Glu Ser Thr Val Cys Val Thr Asn Val Arg Ser Phe Thr 
        115                 120                 125             


Ser Ala Phe Leu Phe Ser Ile Glu Val Gln Val Thr Ile Gly Phe Gly 
    130                 135                 140                 


Gly Arg Met Met Thr Glu Glu Cys Pro Leu Ala Ile Thr Val Leu Ile 
145                 150                 155                 160 


Leu Gln Asn Ile Val Gly Leu Ile Ile Asn Ala Val Met Leu Gly Cys 
                165                 170                 175     


Ile Phe Met Lys Thr Ala Gln Ala His Arg Arg Ala Glu Thr Leu Ile 
            180                 185                 190         


Phe Ser Arg His Ala Val Ile Ala Val Arg Asn Gly Lys Leu Cys Phe 
        195                 200                 205             


Met Phe Arg Val Gly Asp Leu Arg Lys Ser Met Ile Ile Ser Ala Ser 
    210                 215                 220                 


Val Arg Ile Gln Val Val Lys Lys Thr Thr Thr Pro Glu Gly Glu Val 
225                 230                 235                 240 


Val Pro Ile His Gln Leu Asp Ile Pro Val Asp Asn Pro Ile Glu Ser 
                245                 250                 255     


Asn Asn Ile Phe Leu Val Ala Pro Leu Ile Ile Cys His Val Ile Asp 
            260                 265                 270         


Lys Arg Ser Pro Leu Tyr Asp Ile Ser Ala Thr Asp Leu Ala Asn Gln 
        275                 280                 285             


Asp Leu Glu Val Ile Val Ile Leu Glu Gly Val Val Glu Thr Thr Gly 
    290                 295                 300                 


Ile Thr Thr Gln Ala Arg Thr Ser Tyr Ile Ala Glu Glu Ile Gln Trp 
305                 310                 315                 320 


Gly His Arg Phe Val Ser Ile Val Thr Glu Glu Glu Gly Val Tyr Ser 
                325                 330                 335     


Val Asp Tyr Ser Lys Phe Gly Asn Thr Val Lys Val Ala Ala Pro Arg 
            340                 345                 350         


Cys Ser Ala Arg Glu Leu Asp Glu Lys Pro Ser Ile Leu Ile Gln Thr 
        355                 360                 365             


Leu Gln Lys Ser Glu Leu Ser His Gln Asn Ser Leu Arg Lys Arg Asn 
    370                 375                 380                 


Ser Met Arg Arg Asn Asn Ser Met Arg Arg Asn Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Asn Asn Ser Ser Leu Met Val Pro Lys Val Gln Phe Met Thr Pro Glu 
                405                 410                 415     


Gly Asn Gln Asn Thr Ser Glu Ser 
            420                 


<210>  26
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Ser Arg Lys Gly Ile Ile Pro Glu Glu Tyr Val Leu Thr Arg 
1               5                   10                  15      


Leu Ala Glu Asp Pro Ala Lys Pro Arg Tyr Arg Ala Arg Gln Arg Arg 
            20                  25                  30          


Ala Arg Phe Val Ser Lys Lys Gly Asn Cys Asn Val Ala His Lys Asn 
        35                  40                  45              


Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Val Phe Thr Thr Leu Val 
    50                  55                  60                  


Asp Leu Lys Trp Pro His Thr Leu Leu Ile Phe Thr Met Ser Phe Leu 
65                  70                  75                  80  


Cys Ser Trp Leu Leu Phe Ala Met Ala Trp Trp Leu Ile Ala Phe Ala 
                85                  90                  95      


His Gly Asp Leu Ala Pro Ser Glu Gly Thr Ala Glu Pro Cys Val Thr 
            100                 105                 110         


Ser Ile His Ser Phe Ser Ser Ala Phe Leu Phe Ser Ile Glu Val Gln 
        115                 120                 125             


Val Thr Ile Gly Phe Gly Gly Arg Met Val Thr Glu Glu Cys Pro Leu 
    130                 135                 140                 


Ala Ile Leu Ile Leu Ile Val Gln Asn Ile Val Gly Leu Met Ile Asn 
145                 150                 155                 160 


Ala Ile Met Leu Gly Cys Ile Phe Met Lys Thr Ala Gln Ala His Arg 
                165                 170                 175     


Arg Ala Glu Thr Leu Ile Phe Ser Lys His Ala Val Ile Ala Leu Arg 
            180                 185                 190         


His Gly Arg Leu Cys Phe Met Leu Arg Val Gly Asp Leu Arg Lys Ser 
        195                 200                 205             


Met Ile Ile Ser Ala Thr Ile His Met Gln Val Val Arg Lys Thr Thr 
    210                 215                 220                 


Ser Pro Glu Gly Glu Val Val Pro Leu His Gln Val Asp Ile Pro Met 
225                 230                 235                 240 


Glu Asn Gly Val Gly Gly Asn Ser Ile Phe Leu Val Ala Pro Leu Ile 
                245                 250                 255     


Ile Tyr His Val Ile Asp Ala Asn Ser Pro Leu Tyr Asp Leu Ala Pro 
            260                 265                 270         


Ser Asp Leu His His His Gln Asp Leu Glu Ile Ile Val Ile Leu Glu 
        275                 280                 285             


Gly Val Val Glu Thr Thr Gly Ile Thr Thr Gln Ala Arg Thr Ser Tyr 
    290                 295                 300                 


Leu Ala Asp Glu Ile Leu Trp Gly Gln Arg Phe Val Pro Ile Val Ala 
305                 310                 315                 320 


Glu Glu Asp Gly Arg Tyr Ser Val Asp Tyr Ser Lys Phe Gly Asn Thr 
                325                 330                 335     


Val Lys Val Pro Thr Pro Leu Cys Thr Ala Arg Gln Leu Asp Glu Asp 
            340                 345                 350         


His Ser Leu Leu Glu Ala Leu Thr Leu Ala Ser Ala Arg Gly Pro Leu 
        355                 360                 365             


Arg Lys Arg Ser Val Pro Met Ala Lys Ala Lys Pro Lys Phe Ser Ile 
    370                 375                 380                 


Ser Pro Asp Ser Leu Ser 
385                 390 


<210>  27
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  28
<211>  427
<212>  PRT
<213>  Gallus gallus

<400>  28

Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Thr Phe Ile Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Glu Asn Gln Glu Asn Asn Lys Pro Cys Val Ser Gln Val Ser Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Val Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Glu Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Met Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys Asn Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Ile Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Glu Ile Asp Thr Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr His Pro Asp Met Asp His His Asn Gln Ala Gly Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210>  29
<211>  429
<212>  PRT
<213>  Gallus gallus

<400>  29

Met Thr Ala Gly Arg Val Asn Pro Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Leu Arg Leu Thr Thr Met Pro Gly Ile Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ile His Thr Arg Arg Lys Cys Arg Asn Arg Phe Val Lys Lys 
        35                  40                  45              


Asn Gly Gln Cys Asn Val Glu Phe Thr Asn Met Asp Asp Lys Pro Gln 
    50                  55                  60                  


Arg Tyr Ile Ala Asp Met Phe Thr Thr Cys Val Asp Ile Arg Trp Arg 
65                  70                  75                  80  


Tyr Met Leu Leu Leu Phe Ser Leu Ala Phe Leu Val Ser Trp Leu Leu 
                85                  90                  95      


Phe Gly Leu Ile Phe Trp Leu Ile Ala Leu Ile His Gly Asp Leu Glu 
            100                 105                 110         


Asn Pro Gly Gly Asp Asp Thr Phe Lys Pro Cys Val Leu Gln Val Asn 
        115                 120                 125             


Gly Phe Val Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Phe Arg Cys Val Thr Glu Glu Cys Pro Leu Ala Val Phe 
145                 150                 155                 160 


Met Val Val Val Gln Ser Ile Val Gly Cys Ile Ile Asp Ser Phe Met 
                165                 170                 175     


Ile Gly Ala Ile Met Ala Lys Met Ala Arg Pro Lys Lys Arg Ala Gln 
            180                 185                 190         


Thr Leu Leu Phe Ser His Asn Ala Val Val Ala Met Arg Asp Gly Lys 
        195                 200                 205             


Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Ile Val 
    210                 215                 220                 


Glu Ala His Val Arg Ala Gln Leu Ile Lys Pro Arg Ile Thr Glu Glu 
225                 230                 235                 240 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asp Val Gly Phe Asp 
                245                 250                 255     


Lys Gly Leu Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Leu His 
            260                 265                 270         


Glu Ile Asn Glu Asp Ser Pro Leu Phe Gly Ile Ser Arg Gln Asp Leu 
        275                 280                 285             


Glu Thr Asp Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu 
    290                 295                 300                 


Ala Thr Ala Met Thr Thr Gln Ala Arg Ser Ser Tyr Leu Ala Ser Glu 
305                 310                 315                 320 


Ile Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe Glu Glu Lys Asn 
                325                 330                 335     


Gln Tyr Lys Val Asp Tyr Ser His Phe His Lys Thr Tyr Glu Val Pro 
            340                 345                 350         


Ser Thr Pro Arg Cys Ser Ala Lys Asp Leu Val Glu Asn Lys Phe Leu 
        355                 360                 365             


Leu Pro Ser Thr Asn Ser Phe Cys Tyr Glu Asn Glu Leu Ala Phe Met 
    370                 375                 380                 


Ser Arg Asp Glu Asp Glu Glu Asp Asp Asp Ser Arg Gly Leu Asp Asp 
385                 390                 395                 400 


Leu Ser Pro Asp Asn Arg His Glu Phe Asp Arg Leu Gln Ala Thr Ile 
                405                 410                 415     


Ala Leu Asp Gln Arg Ser Tyr Arg Arg Glu Ser Glu Ile 
            420                 425                 


<210>  30
<211>  1176
<212>  DNA
<213>  Homo sapiens

<400>  30
atgaatgctt ccagtcggaa tgtgtttgac acgttgatca gggtgttgac agaaagtatg       60

ttcaaacatc ttcggaaatg ggtcgtcact cgcttttttg ggcattctcg gcaaagagca      120

aggctagtct ccaaagatgg aaggtgcaac atagaatttg gcaatgtgga ggcacagtca      180

aggtttatat tctttgtgga catctggaca acggtacttg acctcaagtg gagatacaaa      240

atgaccattt tcatcacagc cttcttgggg agttggtttt tctttggtct cctgtggtat      300

gcagtagcgt acattcacaa agacctcccg gaattccatc cttctgccaa tcacactccc      360

tgtgtggaga atattaatgg cttgacctca gcttttctgt tttctctgga gactcaagtg      420

accattggat atggattcag gtgtgtgaca gaacagtgtg ccactgccat ttttctgctt      480

atctttcagt ctatacttgg agttataatc aattctttca tgtgtggggc catcttagcc      540

aagatctcca ggcccaaaaa acgtgccaag accattacgt tcagcaagaa cgcagtgatc      600

agcaaacggg gagggaagct ttgcctccta atccgagtgg ctaatctcag gaagagcctt      660

cttattggca gtcacattta tggaaagctt ctgaagacca cagtcactcc tgaaggagag      720

accattattt tggaccagat caatatcaac tttgtagttg acgctgggaa tgaaaattta      780

ttcttcatct ccccattgac aatttaccat gtcattgatc acaacagccc tttcttccac      840

atggcagcgg agacccttct ccagcaggac tttgaattag tggtgttttt agatggcaca      900

gtggagtcca ccagtgctac ctgccaagtc cggacatcct atgtcccaga ggaggtgctt      960

tggggctacc gttttgctcc catagtatcc aagacaaagg aagggaaata ccgagtggat     1020

ttccataact ttagcaagac agtggaagtg gagacccctc actgtgccat gtgcctttat     1080

aatgagaaag atgttagagc caggatgaag agaggctatg acaaccccaa cttcatcttg     1140

tcagaagtca atgaaacaga tgacaccaaa atgtaa                               1176


<210>  31
<211>  1282
<212>  DNA
<213>  Homo sapiens

<400>  31
cttttctgat cccagctccg ggtttaagag tcctggcacg gcccgtcgca cagctctgct       60

cctaactcct gcccgccccg tccgtccatc tgtcccgctg ccccgcggcc catccaaggg      120

gccactccac ctcggaccca agatgacgtc agttgccaag gtgtattaca gtcagaccac      180

tcagacagaa agccggcccc taatgggccc agggatacga cggcggagag tcctgacaaa      240

agatggtcgc agcaacgtga gaatggagca cattgccgac aagcgcttcc tctacctcaa      300

ggacctgtgg acaaccttca ttgacatgca gtggcgctac aagcttctgc tcttctctgc      360

gacctttgca ggcacatggt tcctctttgt cgtggtgtgg tatctggtag ctgtggcaca      420

tggggacctg ctggagctgg accccccggc caaccacacc ccctgtgtgg tacaggtgca      480

cacactcact ggagccttcc tcttctccct tgaatcccaa accaccattg gctatggctt      540

ccgctacatc agtgaggaat gtccactagc cattgtgctt cttattgccc agctggtgct      600

caccaccatc ctggaaatct tcatcacagg taccttcctg gcgaagattg cccggcccaa      660

gaagcgggct gagaccattc gtttcagcca gcatgcagtt gtggcctccc acaatggcaa      720

gccctgcctc atgatccgag ttgccaatat gcgcaaaagc ctcctcattg gctgccaggt      780

gacaggaaaa ctgcttcaga cccaccaaac caaggaaggg gagaacatcc ggctcaacca      840

ggtcaatgtg actttccaag tagacacagc ctctgacagc cccttcctta ttctacccct      900

taccttctat catgtggtag atgagaccag tcccttgaaa gatctccctc ttcgcagtgg      960

tgagggtgac tttgagctgg tgctgatcct aagtgggaca gtggagtcca ccagtgccac     1020

ctgtcaggtg cgcacttcct acctgccaga ggagatcctt tggggctacg agttcacacc     1080

tgccatctca ctgtcagcca gtggtaaata catagctgac tttagccttt ttgaccaagt     1140

tgtgaaagtg gcctctccta gtggcctccg tgacagcact gtacgctacg gagaccctga     1200

aaagctcaag ttggaggagt cattaaggga gcaagctgag aaggagggca gtgcccttag     1260

tgtgcgcatc agcaatgtct ga                                              1282


<210>  32
<211>  1326
<212>  DNA
<213>  Homo sapiens

<400>  32
atgggcagtg tgcgaaccaa ccgctacagc atcgtctctt cagaagaaga cggtatgaag       60

ttggccacca tggcagttgc aaatggcttt gggaacggga agagtaaagt ccacacccga      120

caacagtgca ggagccgctt tgtgaagaaa gatggccact gtaatgttca gttcatcaat      180

gtgggtgaga aggggcaacg gtacctcgca gacatcttca ccacgtgtgt ggacattcgc      240

tggcggtgga tgctggttat cttctgcctg gctttcgtcc tgtcatggct gttttttggc      300

tgtgtgtttt ggttgatagc tctgctccat ggggacctgg atgcatccaa agagggcaaa      360

gcttgtgtgt ccgaggtcaa cagcttcacg gctgccttcc tcttctccat tgagacccag      420

acaaccatag gctatggttt cagatgtgtc acggatgaat gcccaattgc tgttttcatg      480

gtggtgttcc agtcaatcgt gggctgcatc atcgatgctt tcatcattgg cgcagtcatg      540

gccaagatgg caaagccaaa gaagagaaac gagactcttg tcttcagtca caatgccgtg      600

attgccatga gagacggcaa gctgtgtttg atgtggcgag tgggcaatct tcggaaaagc      660

cacttggtgg aagctcatgt tcgagcacag ctcctcaaat ccagaattac ttctgaaggg      720

gagtatatcc ctctggatca aatagacatc aatgttgggt ttgacagtgg aatcgatcgt      780

atatttctgg tgtccccaat cactatagtc catgaaatag atgaagacag tcctttatat      840

gatttgagta aacaggacat tgacaacgca gactttgaaa tcgtggtcat actggaaggc      900

atggtggaag ccactgccat gacgacacag tgccgtagct cttatctagc aaatgaaatc      960

ctgtggggcc accgctatga gcctgtgctc tttgaagaga agcactacta caaagtggac     1020

tattccaggt tccacaaaac ttacgaagtc cccaacactc ccctttgtag tgccagagac     1080

ttagcagaaa agaaatatat cctctcaaat gcaaattcat tttgctatga aaatgaagtt     1140

gccctcacaa gcaaagagga agacgacagt gaaaatggag ttccagaaag cactagtacg     1200

gacacgcccc ctgacataga ccttcacaac caggcaagtg tacctctaga gcccaggccc     1260

ttacggcgag agtcggagat atgagtcctg gagcagcggc cctacagacg ggagtcagag     1320

atctga                                                                1326


<210>  33
<211>  1302
<212>  DNA
<213>  Homo sapiens

<400>  33
atgaccgcgg ccagccgggc caacccctac agcatcgtgt catcggagga ggacgggctg       60

cacctggtca ccatgtcggg cgccaacggc ttcggcaacg gcaaggtgca cacgcggcgc      120

aggtgccgca accgcttcgt caagaagaat ggccagtgca acattgagtt cgccaacatg      180

gacgagaagt cacagcgcta cctggctgac atgttcacca cctgtgtgga catccgctgg      240

cggtacatgc tgctcatctt ctcgctggcc ttccttgcct cctggctgct gttcggcatc      300

atcttctggg tcatcgcggt ggcacacggt gacctggagc cggctgaggg ccggggccgc      360

acaccctgtg tgatgcaggt gcacggcttc atggcggcct tcctcttctc catcgagacg      420

cagaccacca tcggctacgg gctgcgctgt gtgacggagg agtgcccggt ggccgtcttc      480

atggtggtgg cccagtccat cgtgggctgc atcatcgact ccttcatgat tggtgccatc      540

atggccaaga tggcaaggcc caagaagcgg gcacagacgc tgctgttcag ccacaacgcc      600

gtggtggccc tgcgtgacgg caagctctgc ctcatgtggc gtgtgggtaa cctgcgcaag      660

agccacattg tggaggccca tgtgcgcgcg cagctcatca agccgcgggt caccgaggag      720

ggcgagtaca tcccgctgga ccagatcgac atcgatgtgg gcttcgacaa gggcctggac      780

cgcatctttc tggtgtcgcc catcaccatc ttgcatgaga ttgacgaggc cagcccgctc      840

ttcggcatca gccggcagga cctggagacg gacgactttg agatcgtggt catcctggaa      900

ggcatggtgg aggccacagc catgaccacc caggcccgca gctcctacct ggccaatgag      960

atcctgtggg gtcaccgctt tgagcccgtg ctcttcgagg agaagaacca gtacaagatt     1020

gactactcgc acttccacaa gacctatgag gtgccctcta cgccccgctg cagtgcgaag     1080

gatctggtag agaacaagtt cctgctgccc agcgccaact ccttctgcta cgagaacgag     1140

ctggccttcc tgagccgtga cgaggaggat gaggcggacg gagaccagga cggccgaagc     1200

cgggacggcc tcagccccca ggccaggcat gactttgaca gactccaggc tggcggcggg     1260

gtcctggagc agcggcccta cagacgggag tcagagatct ga                        1302


<210>  34
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  34
atgcacggac acagccgcaa cggccaggcc cacgtgcccc ggcggaagcg ccgcaaccgc       60

ttcgtcaaga agaacggcca atgcaacgtg tacttcgcca acctgagcaa caagtcgcag      120

cgctacatgg cggacatctt caccacctgc gtggacacgc gctggcgcta catgctcatg      180

atcttctccg cggccttcct tgtctcctgg ctctttttcg gcctcctctt ctggtgtatc      240

gccttcttcc acggtgacct ggaggccagc ccaggggtgc ctgcggcggg gggcccggcg      300

gcgggtggtg gcggagcagc cccggtggcc cccaagccct gcatcatgca cgtgaacggc      360

ttcctgggtg ccttcctgtt ctcggtggag acgcagacga ccatcggcta tgggttccgg      420

tgcgtgacag aggagtgccc gctggcagtc atcgctgtgg tggtccagtc catcgtgggc      480

tgcgtcatcg actccttcat gattggcacc atcatggcca agatggcgcg gcccaagaag      540

cgggcgcaga cgttgctgtt cagccaccac gcggtcattt cggtgcgcga cggcaagctc      600

tgcctcatgt ggcgcgtggg caacctgcgc aagagccaca ttgtggaggc ccacgtgcgg      660

gcccagctca tcaagcccta catgacccag gagggcgagt acctgcccct ggaccagcgg      720

gacctcaacg tgggctatga catcggcctg gaccgcatct tcctggtgtc gcccatcatc      780

attgtccacg agatcgacga ggacagcccg ctttatggca tgggcaagga ggagctggag      840

tcggaggact ttgagatcgt ggtcatcctg gagggcatgg tggaggccac ggccatgacc      900

acccaggccc gcagctccta cctggccagc gagatcctgt ggggccaccg ctttgagcct      960

gtggtcttcg aggagaagag ccactacaag gtggactact cacgttttca caagacctac     1020

gaggtggccg gcacgccctg ctgctcggcc cgggagctgc aggagagtaa gatcaccgtg     1080

ctgcccgccc caccgccccc tcccagtgcc ttctgctacg agaacgagct ggcccttatg     1140

agccaggagg aagaggagat ggaggaggag gcagctgcgg cggccgcggt ggccgcaggc     1200

ctgggcctgg aggcgggttc caaggaggag gcgggcatca tccggatgct ggagttcggc     1260

agccacctgg acctggagcg catgcaggct tccctcccgc tggacaacat ctcctaccgc     1320

agggagtctg ccatctga                                                   1338


<210>  35
<211>  1311
<212>  DNA
<213>  Homo sapiens

<400>  35
atgggcctgg ccagggccct acgccgcctc agcggcgccc tggattcggg agacagccgg       60

gcgggcgatg aagaggaggc cgggcccggg ttgtgccgca acgggtgggc gccggcaccg      120

gtgcagtcac ccgtgggccg gcgccgcggt cgcttcgtca agaaagacgg gcactgcaac      180

gtgcgtttcg taaacctggg tggccagggc gcgcgctacc tgagcgacct gttcaccaca      240

tgcgtggacg tgcgctggcg ctggatgtgc ctgctcttct cctgctcctt cctcgcctcc      300

tggctgctct tcggcctggc cttctggctc attgcctcgc tgcacggcga cctggccgcc      360

ccgccaccgc ccgcgccctg cttctcacac gtggccagct tcctggccgc cttcctcttc      420

gcgctggaga cgcagacgtc catcggctac ggcgtgcgca gcgtcaccga ggagtgcccg      480

gccgctgtgg ccgccgtggt gctgcagtgc attgccggct gcgtgctcga cgccttcgtc      540

gtgggtgctg tcatggccaa gatggccaaa cccaagaagc gcaacgagac gctggtcttc      600

agcgagaacg ccgtcgtggc gctgcgcgac caccgcctct gcctcatgtg gcgcgtcggc      660

aacctgcgcc gcagccacct ggtcgaggcc cacgtgcgtg cccagctgct gcagccccgt      720

gtgaccccag agggtgagta catcccgctg gaccaccagg atgtggatgt gggctttgat      780

ggaggcaccg atcgtatctt cctcgtgtcc cccatcacca tcgtccatga gatcgactct      840

gccagtcctc tgtatgagct aggacgtgcc gagctggcca gggctgactt tgagctggtg      900

gtcattctcg aggggatggt tgaggccaca gccatgacca cacagtgtcg ctcgtcctac      960

ctccctggtg aactgctctg gggccatcgt tttgagccag ttctcttcca gcgtggctcc     1020

cagtatgagg tcgactatcg ccacttccat cgcacttatg aggtcccagg gacaccggtc     1080

tgcagtgcta aggagctgga tgaacgggca gagcaggctt cccacagcct caagtctagt     1140

ttccccggct ctctgactgc attttgttat gagaatgaac ttgctctgag ctgctgccag     1200

gaggaagatg aggacgatga gactgaggaa gggaatgggg tggaaacaga agatggggct     1260

gctagccccc gagttctcac accaaccctg gcgctgaccc tgcctccatg a              1311


<210>  36
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  36
atgtctgcac tccgaaggaa atttggggac gattatcagg tagtgaccac atcgtccagc       60

ggctcgggct tgcagcccca ggggccaggc caggaccctc agcagcagct tgtgcccaag      120

aagaagcggc agcggttcgt ggacaagaac ggccggtgca atgtacagca cggcaacctg      180

ggcagcgaga caagccgcta cctctcggac ctcttcacca cgctggtgga cctcaagtgg      240

cgctggaacc tcttcatctt cattctcacc tacaccgtgg cctggctttt catggcgtcc      300

atgtggtggg tgatcgccta cactcggggc gacctgaaca aagcccacgt cggtaactac      360

acgccttgcg tggccaatgt ctataacttc ccttctgcct tcctcttctt catcgagacg      420

gaggccacca tcggctatgg ctaccgatac atcacagaca agtgccccga gggcatcatc      480

ctcttcctct tccagtccat cctgggctcc atcgtggacg ccttcctcat cggctgcatg      540

ttcatcaaga tgtcccagcc caagaagcgc gccgagaccc tcatgttcag cgagcacgcg      600

gtgatctcca tgagggacgg aaaactcacg cttatgttcc gggtgggcaa cctgcgcaac      660

agccacatgg tctccgcgca gattcgctgc aagctgctca aatctcggca gacacctgag      720

ggtgagttcc ttccccttga ccaacttgaa ctggatgtag gttttagtac aggggcagat      780

caactttttc ttgtgtcccc cctcacaatt tgccacgtga tcgatgccaa aagccccttt      840

tatgacctat cccagcgaag catgcaaact gaacagttcg agattgtcgt catcctagaa      900

ggcattgtgg aaacaactgg gatgacttgt caagctcgaa catcatatac tgaagatgaa      960

gttctttggg gtcatcgttt ttttcctgta atttccttag aagagggatt ctttaaagtt     1020

gattactccc agttccatgc aacatttgaa gtccccaccc caccttacag tgtgaaagag     1080

caggaggaaa tgcttctcat gtcgtcccct ttaatagcac cagccataac taacagcaaa     1140

gaaagacata attctgtgga atgcttagat ggactagatg atattactac aaaactacca     1200

tctaagctgc agaaaattac tggaagagaa gactttccca aaaaactctt gaggatgagt     1260

tctacaactt cagaaaaagc ctacagcttg ggagacttgc ccatgaaact tcaacgaata     1320

agttcagttc cgggcaactc agaagaaaaa ctggtatcta aaaccaccaa gatgttatct     1380

gatcccatga gccagtctgt ggctgatttg ccaccaaagc ttcaaaagat ggctggagga     1440

gcagctagga tggaagggaa ccttccagcc aaattaagaa aaatgaactc tgatcgcttc     1500

acataa                                                                1506


<210>  37
<211>  1260
<212>  DNA
<213>  Homo sapiens

<400>  37
atggctggcg attctaggaa tgccatgaac caggacatgg agattggagt cactccctgg       60

gaccccaaga agattccaaa acaggcccgc gattatgtcc ccattgccac agaccgtacg      120

cgcctgctgg ccgagggcaa gaagccacgc cagcgctaca tggagaagag tggcaagtgc      180

aacgtgcacc acggcaacgt ccaggagacc taccggtacc tgagtgacct cttcaccacc      240

ctggtggacc tcaagtggcg cttcaacttg ctcgtcttca ccatggttta cactgtcacc      300

tggctgttct tcggcttcat ttggtggctc attgcttata tccggggtga cctggaccat      360

gttggcgacc aagagtggat tccttgtgtt gaaaacctca gtggcttcgt gtccgctttc      420

ctgttctcca ttgagaccga aacaaccatt gggtatggct tccgagtcat cacagagaag      480

tgtccagagg ggattatact cctcttggtc caggccatcc tgggctccat cgtcaatgcc      540

ttcatggtgg ggtgcatgtt tgtcaagatc agccagccca agaagagagc ggagaccctc      600

atgttttcca acaacgcagt catctccatg cgggacgaga agctgtgcct catgttccgg      660

gtgggcgacc tccgcaactc ccacatcgtg gaggcctcca tccgggccaa gctcatcaag      720

tcccggcaga ccaaagaggg ggagttcatc cccctgaacc agacagacat caacgtgggc      780

tttgacacgg gcgacgaccg cctcttcctt gtgtctcctc tgatcatctc ccatgagatc      840

aaccagaaga gccctttctg ggagatgtct caggctcagc tgcatcagga agagtttgaa      900

gttgtggtca ttctagaagg gatggtggaa gccacaggca tgacctgcca agcccggagc      960

tcctacatgg atacagaggt gctctggggc caccgattca caccagtcct caccttggaa     1020

aagggcttct atgaggtgga ctacaacacc ttccatgata cctatgagac caacacaccc     1080

agctgctgtg ccaaggagct ggcagaaatg aagagggaag gccggctcct ccagtacctc     1140

cccagccccc cactgctggg gggctgtgct gaggcagggc tggatgcaga ggctgagcag     1200

aatgaagaag atgagcccaa ggggctgggt gggtccaggg aggccagggg ctcggtgtga     1260


<210>  38
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  38
atgacgtcag ttgccaaggt gtattacagt cagaccactc agacagaaag ccggccccta       60

atgggcccag ggatacgacg gcggagagtc ctgacaaaag atggtcgcag caacgtgaga      120

atggagcaca ttgccgacaa gcgcttcctc tacctcaagg acctgtggac aaccttcatt      180

gacatgcagt ggcgctacaa gcttctgctc ttctctgcga cctttgcagg cacatggttc      240

ctctttggcg tggtgtggta tctggtagct gtggcacatg gggacctgct ggagctggac      300

cccccggcca accacacccc ctgtgtggta caggtgcaca cactcactgg agccttcctc      360

ttctcccttg aatcccaaac caccattggc tatggcttcc gctacatcag tgaggaatgt      420

ccactggcca ttgtgcttct tattgcccag ctggtgctca ccaccatcct ggaaatcttc      480

atcacaggta ccttcctggc gaagattgcc cggcccaaga agcgggctga gaccattcgt      540

ttcagccagc atgcagttgt ggcctcccac aatggcaagc cctgcctcat gatccgagtt      600

gccaatatgc gcaaaagcct cctcattggc tgccaggtga caggaaaact gcttcagacc      660

caccaaacca aggaagggga gaacatccgg ctcaaccagg tcaatgtgac tttccaagta      720

gacacagcct ctgacagccc cttccttatt ctacccctta ccttctatca tgtggtagat      780

gagaccagtc ccttgaaaga tctccctctt cgcagtggtg agggtgactt tgagctggtg      840

ctgatcctaa gtgggacagt ggagtccacc agtgccacct gtcaggtgcg cacttcctac      900

ctgccagagg agatcctttg gggctacgag ttcacacctg ccatctcact gtcagccagt      960

ggtaaataca tagctgactt tagccttttt gaccaagttg tgaaagtggc ctctcctagt     1020

ggcctccgtg acagcactgt acgctacgga gaccctgaaa agctcaagtt ggaggagtca     1080

ttaagggagc aagctgagaa ggagggcagt gcccttagtg tgcgcatcag caatgtctga     1140


<210>  39
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  39
atggatgcca ttcacatcgg catgtccagc acccccctgg tgaagcacac tgctggggct       60

gggctcaagg ccaacagacc ccgcgtcatg tccaagagtg ggcacagcaa cgtgagaatt      120

gacaaagtgg atggcatata cctactctac ctgcaagacc tgtggaccac agttatcgac      180

atgaagtgga gatacaaact caccctgttc gctgccactt ttgtgatgac ctggttcctt      240

tttggagtca tctactatgc catcgcgttt attcatgggg acttagaacc cggtgagccc      300

atttcaaatc ataccccctg catcatgaaa gtggactctc tcactggggc gtttctcttt      360

tccctggaat cccagacaac cattggctat ggagtccgtt ccatcacaga ggaatgtcct      420

catgccatct tcctgttggt tgctcagttg gtcatcacga ccttgattga gatcttcatc      480

accggaacct tcctggccaa aatcgccaga cccaaaaagc gggctgagac catcaagttc      540

agccactgtg cagtcatcac caagcagaat gggaagctgt gcttggtgat tcaggtagcc      600

aatatgagga agagcctctt gattcagtgc cagctctctg gcaagctcct gcagacccac      660

gtcaccaagg agggggagcg gattctcctc aaccaagcca ctgtcaaatt ccacgtggac      720

tcctcctctg agagcccctt cctcattctg cccatgacat tctaccatgt gctggatgag      780

acgagccccc tgagagacct cacaccccaa aacctaaagg agaaggagtt tgagcttgtg      840

gtcctcctca atgccactgt ggaatccacc agcgctgtct gccagagccg aacatcttat      900

atcccagagg aaatctactg gggttttgag tttgtgcctg tggtatctct ctccaaaaat      960

ggaaaatatg tggctgattt cagtcagttt gaacagattc ggaaaagccc agattgcaca     1020

ttttactgtg cagattctga gaaacagcaa ctcgaggaga agtacaggca ggaggatcag     1080

agggaaagag aactgaggac acttttatta caacagagca atgtctga                  1128


<210>  40
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  40
atgagctatt acggcagcag ctatcatatt atcaatgcgg acgcaaaata cccaggctac       60

ccgccagagc acattatagc tgagaagaga agagcaagaa gacgattact tcacaaagat      120

ggcagctgta atgtctactt caagcacatt tttggagaat ggggaagcta tgtggttgac      180

atcttcacca ctcttgtgga caccaagtgg cgccatatgt ttgtgatatt ttctttatct      240

tatattctct cgtggttgat atttggctct gtcttttggc tcatagcctt tcatcatggc      300

gatctattaa atgatccaga catcacacct tgtgttgaca acgtccattc tttcacaggg      360

gcctttttgt tctccctaga gacccaaacc accataggat atggttatcg ctgtgttact      420

gaagaatgtt ctgtggccgt gctcatggtg atcctccagt ccatcttaag ttgcatcata      480

aataccttta tcattggagc tgccttggcc aaaatggcaa ctgctcgaaa gagagcccaa      540

accattcgtt tcagctactt tgcacttata ggtatgagag atgggaagct ttgcctcatg      600

tggcgcattg gtgattttcg gccaaaccac gtggtagaag gaacagttag agcccaactt      660

ctccgctata cagaagacag tgaagggagg atgacgatgg catttaaaga cctcaaatta      720

gtcaacgacc aaatcatcct ggtcaccccg gtaactattg tccatgaaat tgaccatgag      780

agccctctgt atgcccttga ccgcaaagca gtagccaaag ataactttga gattttggtg      840

acatttatct atactggtga ttccactgga acatctcacc aatctagaag ctcctatgtt      900

ccccgagaaa ttctctgggg ccataggttt aatgatgtct tggaagttaa gaggaagtat      960

tacaaagtga actgcttaca gtttgaagga agtgtggaag tatatgcccc cttttgcagt     1020

gccaagcaat tggactggaa agaccagcag ctccacatag aaaaagcacc accagttcga     1080

gaatcctgca cgtcggacac caaggcgaga cgaaggtcat ttagtgcagt tgccattgtc     1140

agcagctgtg aaaaccctga ggagaccacc acttccgcca cacatgaata tagggaaaca     1200

ccttatcaga aagctctcct gactttaaac agaatctctg tagaatccca aatgtag        1257


<210>  41
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  41
atgttggcca gaaagagtat catcccggag gagtatgtgc tggcgcgcat cgccgcagag       60

aacctgcgca agccgcgcat ccgagaccgc ctccccaaag cccgcttcat cgccaagagc      120

ggggcctgca acctggcgca taagaacatc cgtgagcaag gacgctttct acaggacatc      180

ttcaccacct tggtggacct gaaatggcgc cacacgctgg tcatctttac catgtccttc      240

ctctgcagct ggctgctctt cgctatcatg tggtggctgg tggcctttgc ccatggggac      300

atctatgctt acatggagaa aagtggaatg gagaaaagtg gtttggagtc cactgtgtgt      360

gtgactaatg tcaggtcttt cacttctgct tttctcttct ccattgaagt tcaagttacc      420

attgggtttg gagggaggat gatgacagag gaatgccctt tggccatcac ggttttgatt      480

ctccagaata ttgtgggttt gatcatcaat gcagtcatgt taggctgcat tttcatgaaa      540

acagctcagg ctcacagaag ggcagaaact ttgattttca gccgccatgc tgtgattgcc      600

gtccgaaatg gcaagctgtg cttcatgttc cgagtgggtg acctgaggaa aagcatgatc      660

attagtgcct ctgtgcgcat ccaggtggtc aagaaaacaa ctacacctga aggggaggtg      720

gttcctattc accaactgga cattcctgtt gataacccaa tcgagagcaa taacattttt      780

ctggtggccc ctttgatcat ctgccacgtg attgacaagc gcagtcccct gtatgacatc      840

tcagcaactg acctggccaa ccaagacttg gaggtcatag ttattctgga aggagtggtt      900

gaaactactg gcatcaccac acaagcacga acctcctaca ttgctgagga gatccaatgg      960

ggccaccgct ttgtgtccat tgtgactgag gaagaaggag tgtattctgt ggattactcc     1020

aaatttggca acactgttaa agtagctgct ccacggtgca gtgcccgaga gctggatgag     1080

aaaccttcca tccttattca gaccctccaa aagagtgaac tgtctcatca aaattctctg     1140

aggaagcgca actccatgag aagaaacaat tccatgagga ggaacaattc tatccgaagg     1200

aacaattctt ccctcatggt accaaaggtg caatttatga ctccagaagg aaatcaaaac     1260

acatcggaat catga                                                      1275


<210>  42
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  42
atgctgtccc gcaagggcat catccccgag gaatacgtgc tgacacgcct ggcagaggac       60

cctgccaagc ccaggtaccg tgcccgccag cggagggccc gctttgtgtc caagaaaggc      120

aactgcaacg tggcccacaa gaacatccgg gagcagggcc gcttcctgca ggacgtgttc      180

accacgctgg tggacctcaa gtggccacac acattgctca tcttcaccat gtccttcctg      240

tgcagctggc tgctcttcgc catggcctgg tggctcatcg ccttcgccca cggtgacctg      300

gcccccagcg agggcactgc tgagccctgt gtcaccagca tccactcctt ctcgtctgcc      360

ttccttttct ccattgaggt ccaagtgact attggctttg gggggcgcat ggtgactgag      420

gagtgcccac tggccatcct gatcctcatc gtgcagaaca tcgtggggct catgatcaac      480

gccatcatgc ttggctgcat cttcatgaag actgcccaag cccaccgcag ggctgagacc      540

ctcatcttca gcaagcatgc ggtgatcgcc ctgcgccacg gccgcctctg cttcatgcta      600

cgtgtgggtg acctccgcaa gagcatgatc atcagcgcca ccatccacat gcaggtggta      660

cgcaagacca ccagccccga gggcgaggtg gtgcccctcc accaggtgga catccccatg      720

gagaacggcg tgggtggcaa cagcatcttc ctggtggccc cgctgatcat ctaccatgtc      780

attgatgcca acagcccact ctacgacctg gcacccagcg acctgcacca ccaccaggac      840

ctcgagatca tcgtcatcct ggaaggcgtg gtggaaacca cgggcatcac cacccaggcc      900

cgcacctcct acctggccga tgagatcctg tggggccagc gctttgtgcc cattgtagct      960

gaggaggacg gacgttactc tgtggactac tccaagtttg gcaacaccgt caaagtgccc     1020

acaccactct gcacggcccg ccagcttgat gaggaccaca gcctactgga agctctgacc     1080

ctcgcctcag cccgcgggcc cctgcgcaag cgcagcgtgc ccatggccaa ggccaagccc     1140

aagttcagca tctctccaga ttccctgtcc tga                                  1173


<210>  43
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  43
atggacagca gtaattgcaa agttattgct cctctcctaa gtcaaagata ccggaggatg       60

gtcaccaagg atggccacag cacacttcaa atggatggcg ctcaaagagg tcttgcatat      120

cttcgagatg cttggggaat cctaatggac atgcgctggc gttggatgat gttggtcttt      180

tctgcttctt ttgttgtcca ctggcttgtc tttgcagtgc tctggtatgt tctggctgag      240

atgaatggtg atctggaact agatcatgat gccccacctg aaaaccacac tatctgtgtc      300

aagtatatca ccagtttcac agctgcattc tccttctccc tggagacaca actcacaatt      360

ggttatggta ccatgttccc cagtggtgac tgtccaagtg caatcgcctt acttgccata      420

caaatgctcc taggcctcat gctagaggct tttatcacag gtgcttttgt ggcgaagatt      480

gcccggccaa aaaatcgagc tttttcaatt cgctttactg acacagcagt agtagctcac      540

atggatggca aacctaatct tatcttccaa gtggccaaca cccgacctag ccctctaacc      600

agtgtccggg tctcagctgt actctatcag gaaagagaaa atggcaaact ctaccagacc      660

agtgtggatt tccaccttga tggcatcagt tctgacgaat gtccattctt catctttcca      720

ctaacgtact atcactccat tacaccatca agtcctctgg ctactctgct ccagcatgaa      780

aatccttctc actttgaatt agttgtattc ctttcagcaa tgcaggaggg cactggagaa      840

atatgccaaa ggaggacatc ctacctaccg tctgaaatca tgttacatca ctgttttgca      900

tctctgttga cccgaggttc caaaggtgaa tatcaaatca agatggagaa ttttgacaag      960

actgtccctg aatttccaac tcctctggtt tctaaaagcc caaacaggac tgacctggat     1020

atccacatca atggacaaag cattgacaat tttcagatct ctgaaacagg actgacagaa     1080

taa                                                                   1083


<210>  44
<211>  1284
<212>  DNA
<213>  Gallus gallus

<400>  44
atgggcagcg tgcgaaccaa ccgctacagc atcgtgtctt cggaagagga cggcatgaag       60

ctggcaacca tggccgttgc caatggcttt gggaatggaa aaagtaaggt acacaccagg      120

cagcagtgca ggagccgctt tgtcaaaaaa gatggccact gcaacgtcca gtttattaat      180

gtgggtgaga agggacagcg atacctcgca gacatcttca ccacttgcgt ggacatccgc      240

tggaggtgga tgctggttat cttctgcctg acattcatcc tctcctggct tttctttggc      300

tgtgtgtttt ggttgattgc gctgttgcac ggggatctgg agaaccaaga aaataacaaa      360

ccgtgtgtct cgcaagtgag cagcttcact gcagcctttc tgttctccat tgagacccag      420

accacgatcg gctatggctt caggtgcgtc acagacgagt gccccattgc tgttttcatg      480

gtggttttcc agtctatagt aggctgcatc attgacgcct tcatcattgg tgccgtcatg      540

gcaaagatgg ctaagccaaa aaagagaaac gaaactcttg tcttcagcca caatgccgtg      600

gtggccatga gagatgggaa actgtgcctg atgtggcgtg tcggaaacct gaggaaaagc      660

cacttggttg aggcacacgt gcgagcacag ctcctcaagt ccaggatcac gtcagaaggg      720

gagtacatcc ctttggatga aatagacatc aatgtagggt ttgacagcgg gatagaccgc      780

atattcctgg tctccccaat tacaatagta cacgaaatag atgaagatag tcctttgtat      840

gacttgagca aacaagacat ggacaatgct gactttgaaa ttgtagtcat tttagagggc      900

atggtggaag ccactgccat gactacccag tgccgcagct catatctggc aaatgaaatc      960

ctctggggcc accgctatga gcccgtactc tttgaagaaa aaaactacta caaagtggac     1020

tattcaaggt tccacaaaac atacgaagtg cccaacacac ccatctgcag tgccagagac     1080

ttagcagaaa agaaatacat tctctcgaac gcaaactcct tttgctacga gaacgaagtg     1140

gccctcacca gcaaggagga ggacgagatc gacacggggg tgcccgagag cacaagcaca     1200

gacacccacc ccgacatgga ccaccacaac caggcaggag tgcccctaga gccacggccg     1260

ctgcggcgtg agtcggaaat atga                                            1284


<210>  45
<211>  1290
<212>  DNA
<213>  Gallus gallus

<400>  45
atgactgcag gcagggtcaa cccttacagc atagtgtcct ccgaggaaga cggactgagg       60

ttgaccacca tgccagggat taacggcttt ggcaatggga aaatccacac caggaggaaa      120

tgcaggaaca ggtttgtaaa gaagaacggt cagtgcaatg tggagttcac caacatggat      180

gacaagccac agaggtacat tgcagacatg ttcaccacgt gcgttgacat ccgttggagg      240

tatatgctct tgctcttctc cctggcattt ctggtatcct ggttattgtt tgggctgatt      300

ttctggctaa ttgcactcat tcatggagat ctagaaaacc caggtggaga tgataccttc      360

aagccttgcg ttctgcaggt caatggcttt gtggctgctt ttctgttctc catcgagacc      420

caaacgacta ttggttatgg cttccgctgt gtgacagagg agtgcccgct cgcagtcttc      480

atggtggtgg ttcagtccat cgtggggtgt ataatcgact ctttcatgat tggtgcaata      540

atggcaaaga tggccaggcc caaaaaaagg gcccagacat tgcttttcag ccataatgca      600

gtagtggcaa tgagagatgg aaaactctgc ctgatgtgga gagttgggaa tctccggaaa      660

agccacatag tagaagccca cgtacgagct caattaatta agcccagaat cacagaagaa      720

ggggagtaca tcccactcga ccaaatagac atcgacgtgg ggtttgacaa aggcttggac      780

cgaatcttct tggtgtcccc cattaccatt ctccatgaga tcaacgaaga cagcccgctg      840

ttcgggatca gccgccagga cttggagacg gatgactttg agattgtggt catcctcgaa      900

ggcatggtag aagccaccgc gatgacgaca caagctcgga gctcctacct ggccagcgag      960

atcctgtggg gccaccgctt cgagcccgtc ttgttcgagg agaaaaacca gtacaaagta     1020

gactattccc acttccacaa aacatacgag gtcccgtcca caccccgctg cagcgccaag     1080

gacttggtgg agaacaaatt cctgctgccc agcaccaact ccttctgcta cgagaatgag     1140

ctggccttca tgagccgcga tgaggatgag gaggatgatg acagcagggg tttggacgac     1200

ctgagcccag acaacaggca cgagttcgac cggcttcagg caacgatagc gttggatcag     1260

aggtcatacc ggagggagtc agaaatatga                                      1290


<210>  46
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  46

His Lys Asp Leu Pro Glu Phe His Pro Ser Ala Asn His Thr Pro Cys 
1               5                   10                  15      


Val Glu Asn Ile Asn Gly 
            20          


<210>  47
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  47

His Gly Asp Leu Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro Cys 
1               5                   10                  15      


Val Val Gln Val His Thr 
            20          


<210>  48
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  48

His Gly Asp Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu 
1               5                   10                  15      


Val Asn Ser 
            


<210>  49
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  49

His Gly Asp Leu Glu Pro Ala Glu Gly Arg Gly Arg Thr Pro Cys Val 
1               5                   10                  15      


Met Gln Val His Gly 
            20      


<210>  50
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  50

His Gly Asp Leu Glu Ala Ser Pro Gly Val Pro Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Gly Ala Ala Pro Val Ala Pro Lys Pro Cys Ile 
            20                  25                  30          


Met His Val Asn Gly 
        35          


<210>  51
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  51

His Gly Asp Leu Ala Ala Pro Pro Pro Pro Ala Pro Cys Phe Ser His 
1               5                   10                  15      


Val Ala Ser 
            


<210>  52
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Gly Asp Leu Asn Lys Ala His Val Gly Asn Tyr Thr Pro Cys Val 
1               5                   10                  15      


Ala Asn Val Tyr Asn 
            20      


<210>  53
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  53

Arg Gly Asp Leu Asp His Val Gly Asp Gln Glu Trp Ile Pro Cys Val 
1               5                   10                  15      


Glu Asn Leu Ser Gly 
            20      


<210>  54
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  54

His Gly Asp Ile Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys Ser 
1               5                   10                  15      


Gly Leu Glu Ser Thr Val Cys Val Thr Asn Val Arg Ser 
            20                  25                  


<210>  55
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  55

His Gly Asp Leu Ala Pro Ser Glu Gly Thr Ala Glu Pro Cys Val Thr 
1               5                   10                  15      


Ser Ile His Ser 
            20  


<210>  56
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  56

Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His Thr 
1               5                   10                  15      


Ile Cys Val Lys Tyr Ile Thr Ser 
            20                  


<210>  57
<211>  19
<212>  PRT
<213>  Gallus gallus

<400>  57

His Gly Asp Leu Glu Asn Gln Glu Asn Asn Lys Pro Cys Val Ser Gln 
1               5                   10                  15      


Val Ser Ser 
            


<210>  58
<211>  22
<212>  PRT
<213>  Gallus gallus

<400>  58

His Gly Asp Leu Glu Asn Pro Gly Gly Asp Asp Thr Phe Lys Pro Cys 
1               5                   10                  15      


Val Leu Gln Val Asn Gly 
            20          


<210>  59
<211>  309
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  59

Ser Pro Ala Arg Lys Pro Pro Arg Gly Gly Arg Arg Ile Trp Ser Gly 
1               5                   10                  15      


Thr Arg Glu Val Ile Ala Tyr Gly Met Pro Ala Ser Val Trp Arg Asp 
            20                  25                  30          


Leu Tyr Tyr Trp Ala Leu Lys Val Ser Trp Pro Val Phe Phe Ala Ser 
        35                  40                  45              


Leu Ala Ala Leu Phe Val Val Asn Asn Thr Leu Phe Ala Leu Leu Tyr 
    50                  55                  60                  


Gln Leu Gly Asp Ala Pro Ile Ala Asn Gln Ser Pro Pro Gly Phe Val 
65                  70                  75                  80  


Gly Ala Phe Phe Phe Ser Val Glu Thr Leu Ala Thr Val Gly Tyr Gly 
                85                  90                  95      


Asp Met His Pro Gln Thr Val Tyr Ala His Ala Ile Ala Thr Leu Glu 
            100                 105                 110         


Ile Phe Val Gly Met Ser Gly Ile Ala Leu Ser Thr Gly Leu Val Phe 
        115                 120                 125             


Ala Arg Phe Ala Arg Pro Arg Ala Lys Ile Met Phe Ala Arg His Ala 
    130                 135                 140                 


Ile Val Arg Pro Phe Asn Gly Arg Met Thr Leu Met Val Arg Ala Ala 
145                 150                 155                 160 


Asn Ala Arg Gln Asn Val Ile Ala Glu Ala Arg Ala Lys Met Arg Leu 
                165                 170                 175     


Met Arg Arg Glu His Ser Ser Glu Gly Tyr Ser Leu Met Lys Ile His 
            180                 185                 190         


Asp Leu Lys Leu Val Arg Asn Glu His Pro Ile Phe Leu Leu Gly Trp 
        195                 200                 205             


Asn Met Met His Val Ile Asp Glu Ser Ser Pro Leu Phe Gly Glu Thr 
    210                 215                 220                 


Pro Glu Ser Leu Ala Glu Gly Arg Ala Met Leu Leu Val Met Ile Glu 
225                 230                 235                 240 


Gly Ser Asp Glu Thr Thr Ala Gln Val Met Gln Ala Arg His Ala Trp 
                245                 250                 255     


Glu His Asp Asp Ile Arg Trp His His Arg Tyr Val Asp Leu Met Ser 
            260                 265                 270         


Asp Val Asp Gly Met Thr His Ile Asp Tyr Thr Arg Phe Asn Asp Thr 
        275                 280                 285             


Glu Pro Val Glu Pro Pro Gly Ala Ala Pro Asp Ala Gln Ala Phe Ala 
    290                 295                 300                 


Ala Lys Pro Gly Glu 
305                 


<210>  60
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Construct

<400>  60

Met Ala Pro Met Leu Ser Gly Leu Leu Ala Arg Leu Val Lys Leu Leu 
1               5                   10                  15      


Leu Gly Arg His Gly Ser Ala Leu His Trp Arg Ala Ala Gly Ala Ala 
            20                  25                  30          


Thr Val Leu Leu Val Ile Val Leu Leu Ala Gly Ser Tyr Leu Ala Val 
        35                  40                  45              


Leu Ala Glu Arg Gly Ala Pro Gly Ala Gln Leu Ile Thr Tyr Pro Arg 
    50                  55                  60                  


Ala Leu Trp Trp Ser Val Glu Thr Ala Thr Thr Val Gly Tyr Gly Asp 
65                  70                  75                  80  


Leu Tyr Pro Val Thr Leu Trp Gly Arg Cys Val Ala Val Val Val Met 
                85                  90                  95      


Val Ala Gly Ile Thr Ser Phe Gly Leu Val Thr Ala Ala Leu Ala Thr 
            100                 105                 110         


Trp Phe Val Gly Arg Glu Gln Glu Arg Arg Gly His 
        115                 120                 


<210>  61
<211>  100
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Artificial Sequence: Note = Synthetic Contruct

<400>  61

Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile 
1               5                   10                  15      


Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp Glu Arg Asp Ser 
            20                  25                  30          


Gln Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val Ser Met 
        35                  40                  45              


Thr Thr Val Gly Tyr Gly Asp Met Val Pro Thr Thr Ile Gly Gly Lys 
    50                  55                  60                  


Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu 
65                  70                  75                  80  


Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu 
                85                  90                  95      


Thr Glu Gly Glu 
            100 


