                         SEQUENCE LISTING

<110>  Alavita Pharmaceuticals, Inc.
 
<120>  Inhibition of the Activation of Coagulation Factor XII by Ligands
        of Phosphatidylserine

<130>  0245.90/02PCT

<140>  PCT/US2010/058937
<141>  2010-12-03

<150>  61/266,787
<151>  2009-12-04

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  2
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  3
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  4
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp 
    


<210>  5
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  6
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210>  7
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln 
465     


<210>  8
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  9
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            500                 505 


<210>  10
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
305                 310                 315     


<210>  11
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ala Met Val Ser Glu 
            340                 345                 350         


Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr Val 
        355                 360                 365             


Gln Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser Pro 
    370                 375                 380                 


Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys Ala 
385                 390                 395                 400 


Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr 
                405                 410                 415     


Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln 
            420                 425                 430         


Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly 
        435                 440                 445             


His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe 
    450                 455                 460                 


Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp Glu 
465                 470                 475                 480 


Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg 
                485                 490                 495     


Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys 
            500                 505                 510         


Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser 
        515                 520                 525             


Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp Leu 
    530                 535                 540                 


Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys 
545                 550                 555                 560 


Gly Thr Asp Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr 
                565                 570                 575     


Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His 
            580                 585                 590         


Asp Met Asn Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys 
        595                 600                 605             


Cys Leu Thr Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe 
    610                 615                 620                 


Ala Glu Lys Leu His Gln Ala Met Lys Gly Val Gly Thr Arg His Lys 
625                 630                 635                 640 


Ala Leu Ile Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met Asn Asp 
                645                 650                 655     


Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala 
            660                 665                 670         


Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu 
        675                 680                 685             


Cys Gly Gly Asn 
    690         


<210>  12
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe 
            340                 345                 350         


Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys 
        355                 360                 365             


Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser 
    370                 375                 380                 


Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp 
385                 390                 395                 400 


Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg 
                405                 410                 415     


Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp 
            420                 425                 430         


Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu 
        435                 440                 445             


Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala 
    450                 455                 460                 


Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu 
465                 470                 475                 480 


Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg 
                485                 490                 495     


Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser 
            500                 505                 510         


Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser 
        515                 520                 525             


Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala 
    530                 535                 540                 


Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe 
545                 550                 555                 560 


Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe 
                565                 570                 575     


Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp 
            580                 585                 590         


Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys 
        595                 600                 605             


Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala 
    610                 615                 620                 


Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val 
625                 630                 635                 640 


Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys 
                645                 650                 655     


Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly 
            660                 665                 670         


Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
        675                 680                 685 


<210>  13
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe 
                325                 330                 335     


Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys 
            340                 345                 350         


Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser 
        355                 360                 365             


Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp 
    370                 375                 380                 


Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg 
385                 390                 395                 400 


Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp 
                405                 410                 415     


Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu 
            420                 425                 430         


Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala 
        435                 440                 445             


Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu 
    450                 455                 460                 


Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg 
465                 470                 475                 480 


Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser 
                485                 490                 495     


Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser 
            500                 505                 510         


Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala 
        515                 520                 525             


Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe 
    530                 535                 540                 


Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe 
545                 550                 555                 560 


Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp 
                565                 570                 575     


Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys 
            580                 585                 590         


Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala 
        595                 600                 605             


Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val 
    610                 615                 620                 


Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys 
625                 630                 635                 640 


Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly 
                645                 650                 655     


Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            660                 665                 


<210>  14
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu 
                325                 330                 335     


Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly 
            340                 345                 350         


Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp 
        355                 360                 365             


Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala 
    370                 375                 380                 


Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr 
                405                 410                 415     


Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu 
            420                 425                 430         


Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met 
        435                 440                 445             


Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser 
    450                 455                 460                 


Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu 
465                 470                 475                 480 


Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp 
                485                 490                 495     


Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp 
            500                 505                 510         


Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr 
        515                 520                 525             


Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr 
    530                 535                 540                 


Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys 
545                 550                 555                 560 


Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu 
                565                 570                 575     


Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala 
            580                 585                 590         


Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys 
        595                 600                 605             


Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg 
    610                 615                 620                 


Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr 
625                 630                 635                 640 


Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr 
                645                 650                 655     


Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            660                 665         


<210>  15
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
                325                 330                 335     


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            340                 345                 350         


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        355                 360                 365             


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    370                 375                 380                 


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
385                 390                 395                 400 


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                405                 410                 415     


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            420                 425                 430         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        435                 440                 445             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    450                 455                 460                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
465                 470                 475                 480 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                485                 490                 495     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            500                 505                 510         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        515                 520                 525             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    530                 535                 540                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
545                 550                 555                 560 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                565                 570                 575     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            580                 585                 590         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        595                 600                 605             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    610                 615                 620                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
625                 630                 635                 640 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                645                 650                 655     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            660                 665     


<210>  16
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu 
        675                 680                 685             


Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly 
    690                 695                 700                 


Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp 
705                 710                 715                 720 


Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala 
                725                 730                 735     


Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln 
            740                 745                 750         


Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr 
        755                 760                 765             


Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu 
    770                 775                 780                 


Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met 
785                 790                 795                 800 


Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser 
                805                 810                 815     


Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu 
            820                 825                 830         


Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp 
        835                 840                 845             


Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp 
    850                 855                 860                 


Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr 
865                 870                 875                 880 


Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr 
                885                 890                 895     


Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys 
            900                 905                 910         


Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu 
        915                 920                 925             


Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala 
    930                 935                 940                 


Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys 
945                 950                 955                 960 


Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg 
                965                 970                 975     


Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr 
            980                 985                 990         


Gly Ile Ser Leu Cys Gln Ala Ile  Leu Asp Glu Thr Lys  Gly Asp Tyr 
        995                 1000                 1005             


Glu Lys  Ile Leu Val Ala Leu  Cys Gly Gly Asn 
    1010                 1015                 


<210>  17
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile 
465                 470                 475                 480 


Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly 
                485                 490                 495     


Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser 
            500                 505                 510         


Asp Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu 
        515                 520                 525             


Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln 
    530                 535                 540                 


Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu 
545                 550                 555                 560 


Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala 
                565                 570                 575     


Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala 
            580                 585                 590         


Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala 
        595                 600                 605             


Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu 
    610                 615                 620                 


Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly 
625                 630                 635                 640 


Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu 
                645                 650                 655     


Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu 
            660                 665                 670         


Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn 
        675                 680                 685             


Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln 
    690                 695                 700                 


Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu 
705                 710                 715                 720 


Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys 
                725                 730                 735     


Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met 
            740                 745                 750         


Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser 
        755                 760                 765             


Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met 
    770                 775                 780                 


Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp 
785                 790                 795                 800 


Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
                805                 810         


<210>  18
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Met Val Ser Glu Phe Leu Lys 
                325                 330                 335     


Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val 
            340                 345                 350         


Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr 
        355                 360                 365             


Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val 
    370                 375                 380                 


Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn 
385                 390                 395                 400 


Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly 
                405                 410                 415     


Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu 
            420                 425                 430         


Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp 
        435                 440                 445             


Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu 
    450                 455                 460                 


Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn 
465                 470                 475                 480 


Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr 
                485                 490                 495     


Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys 
            500                 505                 510         


Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser 
        515                 520                 525             


Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp 
    530                 535                 540                 


Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu 
545                 550                 555                 560 


Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn 
                565                 570                 575     


Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr 
            580                 585                 590         


Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys 
        595                 600                 605             


Leu His Gln Ala Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile 
    610                 615                 620                 


Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala 
625                 630                 635                 640 


Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp 
                645                 650                 655     


Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly 
            660                 665                 670         


Asn 
    


<210>  19
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Met Val Ser Glu Phe 
            500                 505                 510         


Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln 
        515                 520                 525             


Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr 
    530                 535                 540                 


Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys Ala Ile 
545                 550                 555                 560 


Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys 
                565                 570                 575     


Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu 
            580                 585                 590         


Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly His 
        595                 600                 605             


Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp 
    610                 615                 620                 


Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
625                 630                 635                 640 


Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp 
                645                 650                 655     


Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp 
            660                 665                 670         


Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu 
        675                 680                 685             


Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp Leu Ala 
    690                 695                 700                 


Asp Ser Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly 
705                 710                 715                 720 


Thr Asp Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro 
                725                 730                 735     


Gln Leu Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp 
            740                 745                 750         


Met Asn Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys 
        755                 760                 765             


Leu Thr Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala 
    770                 775                 780                 


Glu Lys Leu His Gln Ala Met Lys Gly Val Gly Thr Arg His Lys Ala 
785                 790                 795                 800 


Leu Ile Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met Asn Asp Ile 
                805                 810                 815     


Lys Ala Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile 
            820                 825                 830         


Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys 
        835                 840                 845             


Gly Gly Asn 
    850     


<210>  20
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Met Val 
305                 310                 315                 320 


Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu 
                325                 330                 335     


Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val 
            340                 345                 350         


Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His 
        355                 360                 365             


Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile 
    370                 375                 380                 


Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr 
385                 390                 395                 400 


Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu 
                405                 410                 415     


Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala 
            420                 425                 430         


Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr 
        435                 440                 445             


Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu 
    450                 455                 460                 


Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu 
465                 470                 475                 480 


Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu 
                485                 490                 495     


Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu 
            500                 505                 510         


Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg 
        515                 520                 525             


Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg 
    530                 535                 540                 


Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser 
545                 550                 555                 560 


Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile 
                565                 570                 575     


Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala 
            580                 585                 590         


Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly Val Gly Thr Arg 
        595                 600                 605             


His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met 
    610                 615                 620                 


Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys 
625                 630                 635                 640 


Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val 
                645                 650                 655     


Ala Leu Cys Gly Gly Asn 
            660         


<210>  21
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ser Thr Val His Glu 
            340                 345                 350         


Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser 
        355                 360                 365             


Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn Phe Asp Ala Glu Arg Asp 
    370                 375                 380                 


Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr Lys Gly Val Asp Glu Val 
385                 390                 395                 400 


Thr Ile Val Asn Ile Leu Thr Asn Arg Ser Asn Ala Gln Arg Gln Asp 
                405                 410                 415     


Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys Lys Glu Leu Ala Ser Ala 
            420                 425                 430         


Leu Lys Ser Ala Leu Ser Gly His Leu Glu Thr Val Ile Leu Gly Leu 
        435                 440                 445             


Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser Glu Leu Lys Ala Ser Met 
    450                 455                 460                 


Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu Ile Glu Ile Ile Cys Ser 
465                 470                 475                 480 


Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn Arg Val Tyr Lys Glu Met 
                485                 490                 495     


Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile Ser Asp Thr Ser Gly Asp 
            500                 505                 510         


Phe Arg Lys Leu Met Val Ala Leu Ala Lys Gly Arg Arg Ala Glu Asp 
        515                 520                 525             


Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp Gln Asp Ala Arg Asp Leu 
    530                 535                 540                 


Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr Asp Val Pro Lys Trp Ile 
545                 550                 555                 560 


Ser Ile Met Thr Glu Arg Ser Val Pro His Leu Gln Lys Val Phe Asp 
                565                 570                 575     


Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met Leu Glu Ser Ile Arg Lys 
            580                 585                 590         


Glu Val Lys Gly Asp Leu Glu Asn Ala Phe Leu Asn Leu Val Gln Cys 
        595                 600                 605             


Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp Arg Leu Tyr Asp Ser Met 
    610                 615                 620                 


Lys Gly Lys Gly Thr Arg Asp Lys Val Leu Ile Arg Ile Met Val Ser 
625                 630                 635                 640 


Arg Ser Glu Val Asp Met Leu Lys Ile Arg Ser Glu Phe Lys Arg Lys 
                645                 650                 655     


Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln Gln Asp Thr Lys Gly Asp 
            660                 665                 670         


Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly Gly Asp Asp 
        675                 680                 685 


<210>  22
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu 
            340                 345                 350         


Glu Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala 
        355                 360                 365             


Tyr Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala 
    370                 375                 380                 


Ile Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr 
385                 390                 395                 400 


Asn Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg 
                405                 410                 415     


Arg Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly 
            420                 425                 430         


His Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr 
        435                 440                 445             


Asp Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu 
    450                 455                 460                 


Asp Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln 
465                 470                 475                 480 


Glu Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys 
                485                 490                 495     


Asp Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala 
            500                 505                 510         


Leu Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu 
        515                 520                 525             


Leu Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg 
    530                 535                 540                 


Lys Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser 
545                 550                 555                 560 


Val Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro 
                565                 570                 575     


Tyr Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu 
            580                 585                 590         


Asn Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr 
        595                 600                 605             


Phe Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp 
    610                 615                 620                 


Lys Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu 
625                 630                 635                 640 


Lys Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr 
                645                 650                 655     


Tyr Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr 
            660                 665                 670         


Leu Cys Gly Gly Asp Asp 
        675             


<210>  23
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu 
                325                 330                 335     


Glu Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala 
            340                 345                 350         


Tyr Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala 
        355                 360                 365             


Ile Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr 
    370                 375                 380                 


Asn Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg 
385                 390                 395                 400 


Arg Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly 
                405                 410                 415     


His Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr 
            420                 425                 430         


Asp Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu 
        435                 440                 445             


Asp Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln 
    450                 455                 460                 


Glu Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys 
465                 470                 475                 480 


Asp Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala 
                485                 490                 495     


Leu Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu 
            500                 505                 510         


Leu Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg 
        515                 520                 525             


Lys Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser 
    530                 535                 540                 


Val Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro 
545                 550                 555                 560 


Tyr Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu 
                565                 570                 575     


Asn Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr 
            580                 585                 590         


Phe Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp 
        595                 600                 605             


Lys Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu 
    610                 615                 620                 


Lys Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr 
625                 630                 635                 640 


Tyr Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr 
                645                 650                 655     


Leu Cys Gly Gly Asp Asp 
            660         


<210>  24
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly 
                325                 330                 335     


Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr 
            340                 345                 350         


Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys 
        355                 360                 365             


Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg 
    370                 375                 380                 


Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr 
385                 390                 395                 400 


Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu 
                405                 410                 415     


Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala 
            420                 425                 430         


Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser 
        435                 440                 445             


Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile 
    450                 455                 460                 


Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile 
465                 470                 475                 480 


Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala 
                485                 490                 495     


Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile 
            500                 505                 510         


Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly 
        515                 520                 525             


Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro 
    530                 535                 540                 


His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp 
545                 550                 555                 560 


Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala 
                565                 570                 575     


Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala 
            580                 585                 590         


Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val 
        595                 600                 605             


Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile 
    610                 615                 620                 


Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile 
625                 630                 635                 640 


Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys 
                645                 650                 655     


Gly Gly Asp Asp 
            660 


<210>  25
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
                325                 330                 335     


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            340                 345                 350         


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        355                 360                 365             


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    370                 375                 380                 


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                405                 410                 415     


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            420                 425                 430         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        435                 440                 445             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    450                 455                 460                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
465                 470                 475                 480 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                485                 490                 495     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            500                 505                 510         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        515                 520                 525             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    530                 535                 540                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
545                 550                 555                 560 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                565                 570                 575     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            580                 585                 590         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        595                 600                 605             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    610                 615                 620                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
625                 630                 635                 640 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                645                 650                 655     


Gly Asp Asp 
            


<210>  26
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly 
        675                 680                 685             


Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr 
    690                 695                 700                 


Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys 
705                 710                 715                 720 


Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg 
                725                 730                 735     


Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr 
            740                 745                 750         


Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu 
        755                 760                 765             


Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala 
    770                 775                 780                 


Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser 
785                 790                 795                 800 


Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile 
                805                 810                 815     


Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile 
            820                 825                 830         


Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala 
        835                 840                 845             


Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile 
    850                 855                 860                 


Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly 
865                 870                 875                 880 


Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro 
                885                 890                 895     


His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp 
            900                 905                 910         


Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala 
        915                 920                 925             


Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala 
    930                 935                 940                 


Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val 
945                 950                 955                 960 


Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile 
                965                 970                 975     


Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile 
            980                 985                 990         


Gln Gln Asp Thr Lys Gly Asp Tyr  Gln Lys Ala Leu Leu  Tyr Leu Cys 
        995                 1000                 1005             


Gly Gly  Asp Asp 
    1010         


<210>  27
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu 
465                 470                 475                 480 


Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr 
                485                 490                 495     


Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile 
            500                 505                 510         


Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn 
        515                 520                 525             


Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg 
    530                 535                 540                 


Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His 
545                 550                 555                 560 


Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp 
                565                 570                 575     


Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp 
            580                 585                 590         


Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu 
        595                 600                 605             


Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp 
    610                 615                 620                 


Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu 
625                 630                 635                 640 


Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu 
                645                 650                 655     


Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys 
            660                 665                 670         


Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val 
        675                 680                 685             


Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr 
    690                 695                 700                 


Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn 
705                 710                 715                 720 


Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe 
                725                 730                 735     


Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys 
            740                 745                 750         


Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys 
        755                 760                 765             


Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr 
    770                 775                 780                 


Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu 
785                 790                 795                 800 


Cys Gly Gly Asp Asp 
                805 


<210>  28
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ser Thr Val His Glu Ile Leu Cys 
                325                 330                 335     


Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly 
            340                 345                 350         


Ser Val Lys Ala Tyr Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn 
        355                 360                 365             


Ile Glu Thr Ala Ile Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val 
    370                 375                 380                 


Asn Ile Leu Thr Asn Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe 
385                 390                 395                 400 


Ala Tyr Gln Arg Arg Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser 
                405                 410                 415     


Ala Leu Ser Gly His Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr 
            420                 425                 430         


Pro Ala Gln Tyr Asp Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu 
        435                 440                 445             


Gly Thr Asp Glu Asp Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn 
    450                 455                 460                 


Gln Glu Leu Gln Glu Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr 
465                 470                 475                 480 


Asp Leu Glu Lys Asp Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys 
                485                 490                 495     


Leu Met Val Ala Leu Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val 
            500                 505                 510         


Ile Asp Tyr Glu Leu Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala 
        515                 520                 525             


Gly Val Lys Arg Lys Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met 
    530                 535                 540                 


Thr Glu Arg Ser Val Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys 
545                 550                 555                 560 


Ser Tyr Ser Pro Tyr Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys 
                565                 570                 575     


Gly Asp Leu Glu Asn Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn 
            580                 585                 590         


Lys Pro Leu Tyr Phe Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys 
        595                 600                 605             


Gly Thr Arg Asp Lys Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu 
    610                 615                 620                 


Val Asp Met Leu Lys Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys 
625                 630                 635                 640 


Ser Leu Tyr Tyr Tyr Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys 
                645                 650                 655     


Ala Leu Leu Tyr Leu Cys Gly Gly Asp Asp 
            660                 665     


<210>  29
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ser Thr Val His Glu Ile 
            500                 505                 510         


Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser Ala 
        515                 520                 525             


Tyr Gly Ser Val Lys Ala Tyr Thr Asn Phe Asp Ala Glu Arg Asp Ala 
    530                 535                 540                 


Leu Asn Ile Glu Thr Ala Ile Lys Thr Lys Gly Val Asp Glu Val Thr 
545                 550                 555                 560 


Ile Val Asn Ile Leu Thr Asn Arg Ser Asn Ala Gln Arg Gln Asp Ile 
                565                 570                 575     


Ala Phe Ala Tyr Gln Arg Arg Thr Lys Lys Glu Leu Ala Ser Ala Leu 
            580                 585                 590         


Lys Ser Ala Leu Ser Gly His Leu Glu Thr Val Ile Leu Gly Leu Leu 
        595                 600                 605             


Lys Thr Pro Ala Gln Tyr Asp Ala Ser Glu Leu Lys Ala Ser Met Lys 
    610                 615                 620                 


Gly Leu Gly Thr Asp Glu Asp Ser Leu Ile Glu Ile Ile Cys Ser Arg 
625                 630                 635                 640 


Thr Asn Gln Glu Leu Gln Glu Ile Asn Arg Val Tyr Lys Glu Met Tyr 
                645                 650                 655     


Lys Thr Asp Leu Glu Lys Asp Ile Ile Ser Asp Thr Ser Gly Asp Phe 
            660                 665                 670         


Arg Lys Leu Met Val Ala Leu Ala Lys Gly Arg Arg Ala Glu Asp Gly 
        675                 680                 685             


Ser Val Ile Asp Tyr Glu Leu Ile Asp Gln Asp Ala Arg Asp Leu Tyr 
    690                 695                 700                 


Asp Ala Gly Val Lys Arg Lys Gly Thr Asp Val Pro Lys Trp Ile Ser 
705                 710                 715                 720 


Ile Met Thr Glu Arg Ser Val Pro His Leu Gln Lys Val Phe Asp Arg 
                725                 730                 735     


Tyr Lys Ser Tyr Ser Pro Tyr Asp Met Leu Glu Ser Ile Arg Lys Glu 
            740                 745                 750         


Val Lys Gly Asp Leu Glu Asn Ala Phe Leu Asn Leu Val Gln Cys Ile 
        755                 760                 765             


Gln Asn Lys Pro Leu Tyr Phe Ala Asp Arg Leu Tyr Asp Ser Met Lys 
    770                 775                 780                 


Gly Lys Gly Thr Arg Asp Lys Val Leu Ile Arg Ile Met Val Ser Arg 
785                 790                 795                 800 


Ser Glu Val Asp Met Leu Lys Ile Arg Ser Glu Phe Lys Arg Lys Tyr 
                805                 810                 815     


Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln Gln Asp Thr Lys Gly Asp Tyr 
            820                 825                 830         


Gln Lys Ala Leu Leu Tyr Leu Cys Gly Gly Asp Asp 
        835                 840                 


<210>  30
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ser Thr Val 
305                 310                 315                 320 


His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro 
                325                 330                 335     


Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn Phe Asp Ala Glu 
            340                 345                 350         


Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr Lys Gly Val Asp 
        355                 360                 365             


Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser Asn Ala Gln Arg 
    370                 375                 380                 


Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys Lys Glu Leu Ala 
385                 390                 395                 400 


Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu Thr Val Ile Leu 
                405                 410                 415     


Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser Glu Leu Lys Ala 
            420                 425                 430         


Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu Ile Glu Ile Ile 
        435                 440                 445             


Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn Arg Val Tyr Lys 
    450                 455                 460                 


Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile Ser Asp Thr Ser 
465                 470                 475                 480 


Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys Gly Arg Arg Ala 
                485                 490                 495     


Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp Gln Asp Ala Arg 
            500                 505                 510         


Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr Asp Val Pro Lys 
        515                 520                 525             


Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His Leu Gln Lys Val 
    530                 535                 540                 


Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe Leu Asn Leu Val 
                565                 570                 575     


Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp Arg Leu Tyr Asp 
            580                 585                 590         


Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu Ile Arg Ile Met 
        595                 600                 605             


Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg Ser Glu Phe Lys 
    610                 615                 620                 


Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln Gln Asp Thr Lys 
625                 630                 635                 640 


Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly Gly Asp Asp 
                645                 650                 655 


<210>  31
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ala Ser Ile Trp Val 
            340                 345                 350         


Gly His Arg Gly Thr Val Arg Asp Tyr Pro Asp Phe Ser Pro Ser Val 
        355                 360                 365             


Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg Gly Ile Gly Thr Asp Glu 
    370                 375                 380                 


Lys Met Leu Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln Arg Gln 
385                 390                 395                 400 


Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp 
                405                 410                 415     


Asp Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala 
            420                 425                 430         


Leu Val Thr Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser 
        435                 440                 445             


Met Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile Leu Thr 
    450                 455                 460                 


Thr Arg Thr Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Thr 
465                 470                 475                 480 


Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr Ser Gly 
                485                 490                 495     


Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg Asp Glu 
            500                 505                 510         


Ser Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu 
        515                 520                 525             


Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys Phe Thr 
    530                 535                 540                 


Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr Phe Asp 
545                 550                 555                 560 


Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly 
                565                 570                 575     


Glu Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys 
            580                 585                 590         


Val Arg Asn Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu 
        595                 600                 605             


Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met Val Ser 
    610                 615                 620                 


Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys Lys His 
625                 630                 635                 640 


Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser Gly Asp 
                645                 650                 655     


Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
            660                 665                 


<210>  32
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg 
            340                 345                 350         


Asp Tyr Pro Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys 
        355                 360                 365             


Ala Ile Arg Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu 
    370                 375                 380                 


Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln 
385                 390                 395                 400 


Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser 
                405                 410                 415     


Gly His Phe Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val 
            420                 425                 430         


Phe Asp Ala Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn 
        435                 440                 445             


Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met 
    450                 455                 460                 


Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly 
465                 470                 475                 480 


Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu 
                485                 490                 495     


Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His 
            500                 505                 510         


Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg 
        515                 520                 525             


Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser 
    530                 535                 540                 


Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln 
545                 550                 555                 560 


Lys Asp Ile Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu 
                565                 570                 575     


Asp Leu Leu Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe 
            580                 585                 590         


Leu Ala Glu Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu 
        595                 600                 605             


Phe Thr Leu Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu 
    610                 615                 620                 


Asp Ile Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser 
625                 630                 635                 640 


Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys 
                645                 650                 655     


Ile Cys Gly Gly Asp Asp 
            660         


<210>  33
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg 
                325                 330                 335     


Asp Tyr Pro Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys 
            340                 345                 350         


Ala Ile Arg Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu 
        355                 360                 365             


Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln 
    370                 375                 380                 


Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser 
385                 390                 395                 400 


Gly His Phe Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val 
                405                 410                 415     


Phe Asp Ala Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn 
            420                 425                 430         


Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met 
        435                 440                 445             


Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly 
    450                 455                 460                 


Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu 
465                 470                 475                 480 


Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His 
                485                 490                 495     


Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg 
            500                 505                 510         


Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser 
        515                 520                 525             


Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln 
    530                 535                 540                 


Lys Asp Ile Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu 
545                 550                 555                 560 


Asp Leu Leu Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe 
                565                 570                 575     


Leu Ala Glu Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu 
            580                 585                 590         


Phe Thr Leu Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu 
        595                 600                 605             


Asp Ile Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser 
    610                 615                 620                 


Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys 
625                 630                 635                 640 


Ile Cys Gly Gly Asp Asp 
                645     


<210>  34
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr 
                325                 330                 335     


Pro Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile 
            340                 345                 350         


Arg Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu 
        355                 360                 365             


Arg Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala 
    370                 375                 380                 


Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His 
385                 390                 395                 400 


Phe Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp 
                405                 410                 415     


Ala Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp 
            420                 425                 430         


Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp 
        435                 440                 445             


Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp 
    450                 455                 460                 


Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu 
465                 470                 475                 480 


Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala 
                485                 490                 495     


Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly 
            500                 505                 510         


Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro 
        515                 520                 525             


Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp 
    530                 535                 540                 


Ile Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu 
545                 550                 555                 560 


Leu Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala 
                565                 570                 575     


Glu Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr 
            580                 585                 590         


Leu Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile 
        595                 600                 605             


Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile 
    610                 615                 620                 


Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys 
625                 630                 635                 640 


Gly Gly Asp Asp 
                


<210>  35
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
                325                 330                 335     


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            340                 345                 350         


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        355                 360                 365             


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    370                 375                 380                 


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
385                 390                 395                 400 


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                405                 410                 415     


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            420                 425                 430         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        435                 440                 445             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    450                 455                 460                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
465                 470                 475                 480 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                485                 490                 495     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            500                 505                 510         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        515                 520                 525             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    530                 535                 540                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
545                 550                 555                 560 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                565                 570                 575     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            580                 585                 590         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        595                 600                 605             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    610                 615                 620                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
625                 630                 635                 640 


Gly Asp Asp 
            


<210>  36
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr 
        675                 680                 685             


Pro Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile 
    690                 695                 700                 


Arg Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu 
705                 710                 715                 720 


Arg Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala 
                725                 730                 735     


Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His 
            740                 745                 750         


Phe Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp 
        755                 760                 765             


Ala Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp 
    770                 775                 780                 


Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp 
785                 790                 795                 800 


Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp 
                805                 810                 815     


Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu 
            820                 825                 830         


Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala 
        835                 840                 845             


Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly 
    850                 855                 860                 


Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro 
865                 870                 875                 880 


Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp 
                885                 890                 895     


Ile Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu 
            900                 905                 910         


Leu Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala 
        915                 920                 925             


Glu Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr 
    930                 935                 940                 


Leu Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile 
945                 950                 955                 960 


Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile 
                965                 970                 975     


Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys 
            980                 985                 990         


Gly Gly Asp Asp 
        995     


<210>  37
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp 
465                 470                 475                 480 


Tyr Pro Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala 
                485                 490                 495     


Ile Arg Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr 
            500                 505                 510         


Glu Arg Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala 
        515                 520                 525             


Ala Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly 
    530                 535                 540                 


His Phe Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe 
545                 550                 555                 560 


Asp Ala Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu 
                565                 570                 575     


Asp Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys 
            580                 585                 590         


Asp Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp 
        595                 600                 605             


Asp Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr 
    610                 615                 620                 


Leu Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu 
625                 630                 635                 640 


Ala Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp 
                645                 650                 655     


Gly Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe 
            660                 665                 670         


Pro Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys 
        675                 680                 685             


Asp Ile Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp 
    690                 695                 700                 


Leu Leu Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu 
705                 710                 715                 720 


Ala Glu Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe 
                725                 730                 735     


Thr Leu Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp 
            740                 745                 750         


Ile Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala 
        755                 760                 765             


Ile Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile 
    770                 775                 780                 


Cys Gly Gly Asp Asp 
785                 


<210>  38
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Ser Ile Trp Val Gly His Arg 
                325                 330                 335     


Gly Thr Val Arg Asp Tyr Pro Asp Phe Ser Pro Ser Val Asp Ala Glu 
            340                 345                 350         


Ala Ile Gln Lys Ala Ile Arg Gly Ile Gly Thr Asp Glu Lys Met Leu 
        355                 360                 365             


Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu Ile Val 
    370                 375                 380                 


Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp Leu Lys 
385                 390                 395                 400 


Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala Leu Val Thr 
                405                 410                 415     


Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser Met Lys Gly 
            420                 425                 430         


Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr Arg Thr 
        435                 440                 445             


Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val Tyr Lys 
    450                 455                 460                 


Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp Phe Arg 
465                 470                 475                 480 


Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser Leu Lys 
                485                 490                 495     


Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala 
            500                 505                 510         


Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu Ile Leu 
        515                 520                 525             


Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu Tyr Arg 
    530                 535                 540                 


Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly Glu Leu Ser 
545                 550                 555                 560 


Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys Val Arg Asn 
                565                 570                 575     


Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu Lys Gly Ile 
            580                 585                 590         


Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met Val Ser Arg Ser Glu 
        595                 600                 605             


Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys Lys His Tyr Gly Tyr 
    610                 615                 620                 


Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr Glu Ile 
625                 630                 635                 640 


Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
                645                 650 


<210>  39
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Ser Ile Trp Val Gly 
            500                 505                 510         


His Arg Gly Thr Val Arg Asp Tyr Pro Asp Phe Ser Pro Ser Val Asp 
        515                 520                 525             


Ala Glu Ala Ile Gln Lys Ala Ile Arg Gly Ile Gly Thr Asp Glu Lys 
    530                 535                 540                 


Met Leu Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu 
545                 550                 555                 560 


Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp 
                565                 570                 575     


Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala Leu 
            580                 585                 590         


Val Thr Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser Met 
        595                 600                 605             


Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr 
    610                 615                 620                 


Arg Thr Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val 
625                 630                 635                 640 


Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp 
                645                 650                 655     


Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser 
            660                 665                 670         


Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr 
        675                 680                 685             


Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu 
    690                 695                 700                 


Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu 
705                 710                 715                 720 


Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly Glu 
                725                 730                 735     


Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys Val 
            740                 745                 750         


Arg Asn Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu Lys 
        755                 760                 765             


Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met Val Ser Arg 
    770                 775                 780                 


Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys Lys His Tyr 
785                 790                 795                 800 


Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr 
                805                 810                 815     


Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
            820                 825             


<210>  40
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Ser Ile 
305                 310                 315                 320 


Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro Asp Phe Ser Pro 
                325                 330                 335     


Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg Gly Ile Gly Thr 
            340                 345                 350         


Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln 
        355                 360                 365             


Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu 
    370                 375                 380                 


Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met 
385                 390                 395                 400 


Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys 
                405                 410                 415     


Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile 
            420                 425                 430         


Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr 
        435                 440                 445             


Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr 
    450                 455                 460                 


Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg 
465                 470                 475                 480 


Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln 
                485                 490                 495     


Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys 
            500                 505                 510         


Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr 
        515                 520                 525             


Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile 
    530                 535                 540                 


Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val 
545                 550                 555                 560 


Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg 
                565                 570                 575     


Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met 
            580                 585                 590         


Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys 
        595                 600                 605             


Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser 
    610                 615                 620                 


Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
625                 630                 635                 


<210>  41
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ala Met Ala Thr Lys 
            340                 345                 350         


Gly Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala Met Glu Asp Ala 
        355                 360                 365             


Gln Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Ala 
    370                 375                 380                 


Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr Ala Gln Arg Gln Glu Ile 
385                 390                 395                 400 


Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu Ile Asp Asp Leu 
                405                 410                 415     


Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln Val Ile Val Gly Met Met 
            420                 425                 430         


Thr Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg Arg Ala Met Lys 
        435                 440                 445             


Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala Ser Arg 
    450                 455                 460                 


Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln Thr Tyr Gln Gln Gln Tyr 
465                 470                 475                 480 


Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser Asp Thr Ser Phe Met Phe 
                485                 490                 495     


Gln Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg Asp Glu Gly Asn 
            500                 505                 510         


Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp Leu Tyr Glu 
        515                 520                 525             


Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu Val Lys Phe Leu Thr Val 
    530                 535                 540                 


Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe Asp Glu Tyr 
545                 550                 555                 560 


Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys Ser Glu Thr 
                565                 570                 575     


Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys Cys Met Arg 
            580                 585                 590         


Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser Met Lys Gly 
        595                 600                 605             


Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg Val Met Val Ser Arg Ala 
    610                 615                 620                 


Glu Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys Arg Leu Tyr Gly 
625                 630                 635                 640 


Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly Asp Tyr Arg 
                645                 650                 655     


Lys Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
            660                 665         


<210>  42
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala 
            340                 345                 350         


Ser Gly Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met 
        355                 360                 365             


Lys Gly Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr 
    370                 375                 380                 


Arg Asn Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr 
385                 390                 395                 400 


Ile Gly Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn 
                405                 410                 415     


Phe Glu Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp 
            420                 425                 430         


Val Gln Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly 
        435                 440                 445             


Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg 
    450                 455                 460                 


Ile Ser Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp 
465                 470                 475                 480 


Ile Arg Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu 
                485                 490                 495     


Ser Ala Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val 
            500                 505                 510         


Arg Gln Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly 
        515                 520                 525             


Thr Asp Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn 
    530                 535                 540                 


His Leu Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp 
545                 550                 555                 560 


Ile Glu Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala 
                565                 570                 575     


Leu Leu Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala 
            580                 585                 590         


Glu Lys Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr 
        595                 600                 605             


Leu Ile Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile 
    610                 615                 620                 


Arg Ala His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile 
625                 630                 635                 640 


Lys Gly Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys 
                645                 650                 655     


Gly Gly Asp Asp 
            660 


<210>  43
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala 
                325                 330                 335     


Ser Gly Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met 
            340                 345                 350         


Lys Gly Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr 
        355                 360                 365             


Arg Asn Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr 
    370                 375                 380                 


Ile Gly Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn 
385                 390                 395                 400 


Phe Glu Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp 
                405                 410                 415     


Val Gln Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly 
            420                 425                 430         


Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg 
        435                 440                 445             


Ile Ser Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp 
    450                 455                 460                 


Ile Arg Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu 
465                 470                 475                 480 


Ser Ala Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val 
                485                 490                 495     


Arg Gln Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly 
            500                 505                 510         


Thr Asp Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn 
        515                 520                 525             


His Leu Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp 
    530                 535                 540                 


Ile Glu Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala 
545                 550                 555                 560 


Leu Leu Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala 
                565                 570                 575     


Glu Lys Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr 
            580                 585                 590         


Leu Ile Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile 
        595                 600                 605             


Arg Ala His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile 
    610                 615                 620                 


Lys Gly Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys 
625                 630                 635                 640 


Gly Gly Asp Asp 
                


<210>  44
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly 
                325                 330                 335     


Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly 
            340                 345                 350         


Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn 
        355                 360                 365             


Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly 
    370                 375                 380                 


Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
385                 390                 395                 400 


Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln 
                405                 410                 415     


Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu 
            420                 425                 430         


Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser 
        435                 440                 445             


Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg 
    450                 455                 460                 


Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala 
465                 470                 475                 480 


Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln 
                485                 490                 495     


Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp 
            500                 505                 510         


Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu 
        515                 520                 525             


Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu 
    530                 535                 540                 


Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu 
545                 550                 555                 560 


Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys 
                565                 570                 575     


Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile 
            580                 585                 590         


Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala 
        595                 600                 605             


His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly 
    610                 615                 620                 


Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly 
625                 630                 635                 640 


Asp Asp 
        


<210>  45
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
                325                 330                 335     


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            340                 345                 350         


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        355                 360                 365             


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    370                 375                 380                 


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
385                 390                 395                 400 


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                405                 410                 415     


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            420                 425                 430         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        435                 440                 445             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    450                 455                 460                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
465                 470                 475                 480 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                485                 490                 495     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            500                 505                 510         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        515                 520                 525             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    530                 535                 540                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
545                 550                 555                 560 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                565                 570                 575     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            580                 585                 590         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        595                 600                 605             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    610                 615                 620                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
625                 630                 635                 640 


Asp 
    


<210>  46
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly 
        675                 680                 685             


Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly 
    690                 695                 700                 


Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn 
705                 710                 715                 720 


Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly 
                725                 730                 735     


Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
            740                 745                 750         


Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln 
        755                 760                 765             


Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu 
    770                 775                 780                 


Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser 
785                 790                 795                 800 


Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg 
                805                 810                 815     


Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala 
            820                 825                 830         


Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln 
        835                 840                 845             


Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp 
    850                 855                 860                 


Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu 
865                 870                 875                 880 


Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu 
                885                 890                 895     


Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu 
            900                 905                 910         


Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys 
        915                 920                 925             


Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile 
    930                 935                 940                 


Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala 
945                 950                 955                 960 


His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly 
                965                 970                 975     


Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly 
            980                 985                 990         


Asp Asp 
        


<210>  47
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser 
465                 470                 475                 480 


Gly Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys 
                485                 490                 495     


Gly Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg 
            500                 505                 510         


Asn Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile 
        515                 520                 525             


Gly Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe 
    530                 535                 540                 


Glu Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val 
545                 550                 555                 560 


Gln Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys 
                565                 570                 575     


Leu Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile 
            580                 585                 590         


Ser Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile 
        595                 600                 605             


Arg Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser 
    610                 615                 620                 


Ala Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg 
625                 630                 635                 640 


Gln Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr 
                645                 650                 655     


Asp Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His 
            660                 665                 670         


Leu Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile 
        675                 680                 685             


Glu Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu 
    690                 695                 700                 


Leu Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu 
705                 710                 715                 720 


Lys Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu 
                725                 730                 735     


Ile Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg 
            740                 745                 750         


Ala His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys 
        755                 760                 765             


Gly Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly 
    770                 775                 780                 


Gly Asp Asp 
785         


<210>  48
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Met Ala Thr Lys Gly Gly Thr 
                325                 330                 335     


Val Lys Ala Ala Ser Gly Phe Asn Ala Met Glu Asp Ala Gln Thr Leu 
            340                 345                 350         


Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser 
        355                 360                 365             


Val Leu Ala Tyr Arg Asn Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala 
    370                 375                 380                 


Tyr Lys Ser Thr Ile Gly Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu 
385                 390                 395                 400 


Leu Ser Gly Asn Phe Glu Gln Val Ile Val Gly Met Met Thr Pro Thr 
                405                 410                 415     


Val Leu Tyr Asp Val Gln Glu Leu Arg Arg Ala Met Lys Gly Ala Gly 
            420                 425                 430         


Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu 
        435                 440                 445             


Glu Ile Arg Arg Ile Ser Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg 
    450                 455                 460                 


Leu Glu Asp Asp Ile Arg Ser Asp Thr Ser Phe Met Phe Gln Arg Val 
465                 470                 475                 480 


Leu Val Ser Leu Ser Ala Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp 
                485                 490                 495     


Asp Ala Leu Val Arg Gln Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu 
            500                 505                 510         


Lys Lys Trp Gly Thr Asp Glu Val Lys Phe Leu Thr Val Leu Cys Ser 
        515                 520                 525             


Arg Asn Arg Asn His Leu Leu His Val Phe Asp Glu Tyr Lys Arg Ile 
    530                 535                 540                 


Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser 
545                 550                 555                 560 


Phe Glu Asp Ala Leu Leu Ala Ile Val Lys Cys Met Arg Asn Lys Ser 
                565                 570                 575     


Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr 
            580                 585                 590         


Asp Asp Asn Thr Leu Ile Arg Val Met Val Ser Arg Ala Glu Ile Asp 
        595                 600                 605             


Met Leu Asp Ile Arg Ala His Phe Lys Arg Leu Tyr Gly Lys Ser Leu 
    610                 615                 620                 


Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu 
625                 630                 635                 640 


Leu Val Leu Cys Gly Gly Asp Asp 
                645             


<210>  49
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Met Ala Thr Lys Gly 
            500                 505                 510         


Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala Met Glu Asp Ala Gln 
        515                 520                 525             


Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Ala Ile 
    530                 535                 540                 


Ile Ser Val Leu Ala Tyr Arg Asn Thr Ala Gln Arg Gln Glu Ile Arg 
545                 550                 555                 560 


Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu Ile Asp Asp Leu Lys 
                565                 570                 575     


Ser Glu Leu Ser Gly Asn Phe Glu Gln Val Ile Val Gly Met Met Thr 
            580                 585                 590         


Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg Arg Ala Met Lys Gly 
        595                 600                 605             


Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr 
    610                 615                 620                 


Pro Glu Glu Ile Arg Arg Ile Ser Gln Thr Tyr Gln Gln Gln Tyr Gly 
625                 630                 635                 640 


Arg Arg Leu Glu Asp Asp Ile Arg Ser Asp Thr Ser Phe Met Phe Gln 
                645                 650                 655     


Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg Asp Glu Gly Asn Tyr 
            660                 665                 670         


Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp Leu Tyr Glu Ala 
        675                 680                 685             


Gly Glu Lys Lys Trp Gly Thr Asp Glu Val Lys Phe Leu Thr Val Leu 
    690                 695                 700                 


Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe Asp Glu Tyr Lys 
705                 710                 715                 720 


Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys Ser Glu Thr Ser 
                725                 730                 735     


Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys Cys Met Arg Asn 
            740                 745                 750         


Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser Met Lys Gly Leu 
        755                 760                 765             


Gly Thr Asp Asp Asn Thr Leu Ile Arg Val Met Val Ser Arg Ala Glu 
    770                 775                 780                 


Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys Arg Leu Tyr Gly Lys 
785                 790                 795                 800 


Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly Asp Tyr Arg Lys 
                805                 810                 815     


Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
            820                 825     


<210>  50
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Met Ala 
305                 310                 315                 320 


Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala Met Glu 
                325                 330                 335     


Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu 
            340                 345                 350         


Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr Ala Gln Arg Gln 
        355                 360                 365             


Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu Ile Asp 
    370                 375                 380                 


Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln Val Ile Val Gly 
385                 390                 395                 400 


Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg Arg Ala 
                405                 410                 415     


Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala 
            420                 425                 430         


Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln Thr Tyr Gln Gln 
        435                 440                 445             


Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser Asp Thr Ser Phe 
    450                 455                 460                 


Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg Asp Glu 
465                 470                 475                 480 


Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp Leu 
                485                 490                 495     


Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu Val Lys Phe Leu 
            500                 505                 510         


Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe Asp 
        515                 520                 525             


Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys Ser 
    530                 535                 540                 


Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys Cys 
545                 550                 555                 560 


Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser Met 
                565                 570                 575     


Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg Val Met Val Ser 
            580                 585                 590         


Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys Arg Leu 
        595                 600                 605             


Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly Asp 
    610                 615                 620                 


Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
625                 630                 635         


<210>  51
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ala Gln Val Leu Arg 
            340                 345                 350         


Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Glu 
        355                 360                 365             


Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile 
    370                 375                 380                 


Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser 
385                 390                 395                 400 


Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys 
                405                 410                 415     


Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys 
            420                 425                 430         


Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly 
        435                 440                 445             


Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Arg Thr 
    450                 455                 460                 


Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly 
465                 470                 475                 480 


Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr Tyr Gln 
                485                 490                 495     


Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly 
            500                 505                 510         


Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala 
        515                 520                 525             


Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr Ile Phe 
    530                 535                 540                 


Gly Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys Tyr Met 
545                 550                 555                 560 


Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu Thr Ser 
                565                 570                 575     


Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile Arg Ser 
            580                 585                 590         


Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys Gly Ala 
        595                 600                 605             


Gly Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg Ser Glu 
    610                 615                 620                 


Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe Ala Thr 
625                 630                 635                 640 


Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr Lys Lys 
                645                 650                 655     


Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
            660                 665     


<210>  52
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro 
            340                 345                 350         


Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys 
        355                 360                 365             


Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg 
    370                 375                 380                 


Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe 
                405                 410                 415     


Glu Lys Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala 
            420                 425                 430         


Tyr Glu Leu Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val 
        435                 440                 445             


Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile 
    450                 455                 460                 


Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val 
465                 470                 475                 480 


Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu 
                485                 490                 495     


Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu 
            500                 505                 510         


Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr 
        515                 520                 525             


Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His 
    530                 535                 540                 


Leu Arg Lys Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile 
545                 550                 555                 560 


Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu 
                565                 570                 575     


Leu Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu 
            580                 585                 590         


Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu 
        595                 600                 605             


Ile Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg 
    610                 615                 620                 


Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys 
625                 630                 635                 640 


Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly 
                645                 650                 655     


Glu Asp Asp 
            


<210>  53
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro 
                325                 330                 335     


Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys 
            340                 345                 350         


Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg 
        355                 360                 365             


Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe 
    370                 375                 380                 


Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe 
385                 390                 395                 400 


Glu Lys Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala 
                405                 410                 415     


Tyr Glu Leu Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val 
            420                 425                 430         


Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile 
        435                 440                 445             


Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val 
    450                 455                 460                 


Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu 
465                 470                 475                 480 


Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu 
                485                 490                 495     


Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr 
            500                 505                 510         


Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His 
        515                 520                 525             


Leu Arg Lys Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile 
    530                 535                 540                 


Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu 
545                 550                 555                 560 


Leu Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu 
                565                 570                 575     


Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu 
            580                 585                 590         


Ile Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg 
        595                 600                 605             


Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys 
    610                 615                 620                 


Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly 
625                 630                 635                 640 


Glu Asp Asp 
            


<210>  54
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe 
                325                 330                 335     


Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu 
            340                 345                 350         


Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn 
        355                 360                 365             


Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg 
    370                 375                 380                 


Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys 
385                 390                 395                 400 


Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu 
                405                 410                 415     


Leu Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr 
            420                 425                 430         


Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln 
        435                 440                 445             


Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly 
    450                 455                 460                 


Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala 
465                 470                 475                 480 


Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp 
                485                 490                 495     


Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu 
            500                 505                 510         


Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg 
        515                 520                 525             


Lys Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu 
    530                 535                 540                 


Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala 
545                 550                 555                 560 


Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu 
                565                 570                 575     


Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg 
            580                 585                 590         


Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu 
        595                 600                 605             


Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp 
    610                 615                 620                 


Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp 
625                 630                 635                 640 


Asp 
    


<210>  55
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
                325                 330                 335     


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            340                 345                 350         


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        355                 360                 365             


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    370                 375                 380                 


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
385                 390                 395                 400 


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                405                 410                 415     


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            420                 425                 430         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        435                 440                 445             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    450                 455                 460                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
465                 470                 475                 480 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                485                 490                 495     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            500                 505                 510         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        515                 520                 525             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    530                 535                 540                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
545                 550                 555                 560 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                565                 570                 575     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            580                 585                 590         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        595                 600                 605             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    610                 615                 620                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
625                 630                 635                 640 


<210>  56
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe 
        675                 680                 685             


Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu 
    690                 695                 700                 


Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn 
705                 710                 715                 720 


Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg 
                725                 730                 735     


Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys 
            740                 745                 750         


Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu 
        755                 760                 765             


Leu Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr 
    770                 775                 780                 


Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln 
785                 790                 795                 800 


Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly 
                805                 810                 815     


Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala 
            820                 825                 830         


Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp 
        835                 840                 845             


Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu 
    850                 855                 860                 


Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg 
865                 870                 875                 880 


Lys Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu 
                885                 890                 895     


Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala 
            900                 905                 910         


Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu 
        915                 920                 925             


Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg 
    930                 935                 940                 


Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu 
945                 950                 955                 960 


Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp 
                965                 970                 975     


Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp 
            980                 985                 990         


Asp 
    


<210>  57
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly 
465                 470                 475                 480 


Phe Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly 
                485                 490                 495     


Leu Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser 
            500                 505                 510         


Asn Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly 
        515                 520                 525             


Arg Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu 
    530                 535                 540                 


Lys Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr 
545                 550                 555                 560 


Glu Leu Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu 
                565                 570                 575     


Thr Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys 
            580                 585                 590         


Gln Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val 
        595                 600                 605             


Gly Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln 
    610                 615                 620                 


Ala Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln 
625                 630                 635                 640 


Asp Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp 
                645                 650                 655     


Glu Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu 
            660                 665                 670         


Arg Lys Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu 
        675                 680                 685             


Glu Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu 
    690                 695                 700                 


Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr 
705                 710                 715                 720 


Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile 
                725                 730                 735     


Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys 
            740                 745                 750         


Glu Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly 
        755                 760                 765             


Asp Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu 
    770                 775                 780                 


Asp Asp 
785     


<210>  58
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Gln Val Leu Arg Gly Thr Val 
                325                 330                 335     


Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg 
            340                 345                 350         


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu Thr Leu 
        355                 360                 365             


Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala Ala Phe 
    370                 375                 380                 


Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu 
385                 390                 395                 400 


Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro Ser Arg 
                405                 410                 415     


Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala Gly Thr 
            420                 425                 430         


Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro Glu Glu 
        435                 440                 445             


Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu 
    450                 455                 460                 


Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg Met Leu 
465                 470                 475                 480 


Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu 
                485                 490                 495     


Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu 
            500                 505                 510         


Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly Thr Arg 
        515                 520                 525             


Ser Val Ser His Leu Arg Lys Val Phe Asp Lys Tyr Met Thr Ile Ser 
    530                 535                 540                 


Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly Asn Leu 
545                 550                 555                 560 


Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala 
                565                 570                 575     


Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp 
            580                 585                 590         


Asp His Thr Leu Ile Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu 
        595                 600                 605             


Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser Leu Tyr 
    610                 615                 620                 


Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala Leu Leu 
625                 630                 635                 640 


Leu Leu Cys Gly Glu Asp Asp 
                645         


<210>  59
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Gln Val Leu Arg Gly 
            500                 505                 510         


Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr 
        515                 520                 525             


Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu 
    530                 535                 540                 


Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala 
545                 550                 555                 560 


Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser 
                565                 570                 575     


Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro 
            580                 585                 590         


Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala 
        595                 600                 605             


Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro 
    610                 615                 620                 


Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser 
625                 630                 635                 640 


Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg 
                645                 650                 655     


Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile 
            660                 665                 670         


Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly 
        675                 680                 685             


Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly 
    690                 695                 700                 


Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys Tyr Met Thr 
705                 710                 715                 720 


Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly 
                725                 730                 735     


Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile Arg Ser Ile 
            740                 745                 750         


Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly 
        755                 760                 765             


Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg Ser Glu Ile 
    770                 775                 780                 


Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser 
785                 790                 795                 800 


Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala 
                805                 810                 815     


Leu Leu Leu Leu Cys Gly Glu Asp Asp 
            820                 825 


<210>  60
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Gln Val 
305                 310                 315                 320 


Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp 
                325                 330                 335     


Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu 
            340                 345                 350         


Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu 
        355                 360                 365             


Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp 
    370                 375                 380                 


Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu 
385                 390                 395                 400 


Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu 
                405                 410                 415     


Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser 
            420                 425                 430         


Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu 
        435                 440                 445             


Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr 
    450                 455                 460                 


Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp 
465                 470                 475                 480 


Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe 
                485                 490                 495     


Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr 
            500                 505                 510         


Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys 
        515                 520                 525             


Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu 
    530                 535                 540                 


Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile 
545                 550                 555                 560 


Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys 
                565                 570                 575     


Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg 
            580                 585                 590         


Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe 
        595                 600                 605             


Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr 
    610                 615                 620                 


Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
625                 630                 635     


<210>  61
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ala Lys Pro Ala Gln 
            340                 345                 350         


Gly Ala Lys Tyr Arg Gly Ser Ile His Asp Phe Pro Gly Phe Asp Pro 
        355                 360                 365             


Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala Met Lys Gly Phe Gly Ser 
    370                 375                 380                 


Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr Ser Arg Ser Asn Arg Gln 
385                 390                 395                 400 


Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser Leu Tyr Gly Lys Asp Leu 
                405                 410                 415     


Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly Lys Phe Glu Arg Leu Ile 
            420                 425                 430         


Val Gly Leu Met Arg Pro Pro Ala Tyr Cys Asp Ala Lys Glu Ile Lys 
        435                 440                 445             


Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu Lys Cys Leu Ile Glu Ile 
    450                 455                 460                 


Leu Ala Ser Arg Thr Asn Glu Gln Met His Gln Leu Val Ala Ala Tyr 
465                 470                 475                 480 


Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala Asp Ile Ile Gly Asp Thr 
                485                 490                 495     


Ser Gly His Phe Gln Lys Met Leu Val Val Leu Leu Gln Gly Thr Arg 
            500                 505                 510         


Glu Glu Asp Asp Val Val Ser Glu Asp Leu Val Gln Gln Asp Val Gln 
        515                 520                 525             


Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Ala Gln 
    530                 535                 540                 


Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys Gln His Leu Arg Leu Val 
545                 550                 555                 560 


Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys Pro Ile Glu Ala Ser Ile 
                565                 570                 575     


Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys Leu Met Leu Ala Val Val 
            580                 585                 590         


Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe Ala Glu Arg Leu Phe Lys 
        595                 600                 605             


Ala Met Lys Gly Leu Gly Thr Arg Asp Asn Thr Leu Ile Arg Ile Met 
    610                 615                 620                 


Val Ser Arg Ser Glu Leu Asp Met Leu Asp Ile Arg Glu Ile Phe Arg 
625                 630                 635                 640 


Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met Ile Lys Asn Asp Thr Ser 
                645                 650                 655     


Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu Ser Gly Gly Asp Asp Asp 
            660                 665                 670         


Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala Gln Val Ala Tyr Gln Met 
        675                 680                 685             


Trp Glu Leu Ser Ala Val Ala Arg Val Glu Leu Lys Gly Thr Val Arg 
    690                 695                 700                 


Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp Ala Lys Ala Leu Arg Lys 
705                 710                 715                 720 


Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Ile Ile Asp Ile Ile 
                725                 730                 735     


Thr His Arg Ser Asn Val Gln Arg Gln Gln Ile Arg Gln Thr Phe Lys 
            740                 745                 750         


Ser His Phe Gly Arg Asp Leu Met Thr Asp Leu Lys Ser Glu Ile Ser 
        755                 760                 765             


Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro Ala His 
    770                 775                 780                 


Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly Thr Asp 
785                 790                 795                 800 


Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr Arg Thr Asn Ala Glu Ile 
                805                 810                 815     


Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser Leu Glu 
            820                 825                 830         


Asp Ala Leu Ser Ser Asp Thr Ser Gly His Phe Arg Arg Ile Leu Ile 
        835                 840                 845             


Ser Leu Ala Thr Gly His Arg Glu Glu Gly Gly Glu Asn Leu Asp Gln 
    850                 855                 860                 


Ala Arg Glu Asp Ala Gln Val Ala Ala Glu Ile Leu Glu Ile Ala Asp 
865                 870                 875                 880 


Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu Thr Arg Phe Met Thr Ile 
                885                 890                 895     


Leu Cys Thr Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Glu Phe 
            900                 905                 910         


Ile Lys Met Thr Asn Tyr Asp Val Glu His Thr Ile Lys Lys Glu Met 
        915                 920                 925             


Ser Gly Asp Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser Val Lys 
    930                 935                 940                 


Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly 
945                 950                 955                 960 


Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg Ile Met Val Ser Arg Ser 
                965                 970                 975     


Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp 
            980                 985                 990         


Lys Ser Leu His Gln Ala Ile Glu  Gly Asp Thr Ser Gly  Asp Phe Leu 
        995                 1000                 1005             


Lys Ala  Leu Leu Ala Leu Cys  Gly Gly Glu Asp 
    1010                 1015                 


<210>  62
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser 
            340                 345                 350         


Ile His Asp Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu 
        355                 360                 365             


Tyr Thr Ala Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp 
    370                 375                 380                 


Ile Ile Thr Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser 
385                 390                 395                 400 


Tyr Lys Ser Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu 
                405                 410                 415     


Leu Thr Gly Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro 
            420                 425                 430         


Ala Tyr Cys Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly 
        435                 440                 445             


Thr Asp Glu Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu 
    450                 455                 460                 


Gln Met His Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp 
465                 470                 475                 480 


Leu Glu Ala Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met 
                485                 490                 495     


Leu Val Val Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser 
            500                 505                 510         


Glu Asp Leu Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu 
        515                 520                 525             


Leu Lys Trp Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn 
    530                 535                 540                 


Arg Ser Lys Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr 
545                 550                 555                 560 


Thr Gly Lys Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp 
                565                 570                 575     


Phe Glu Lys Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro 
            580                 585                 590         


Glu Tyr Phe Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr 
        595                 600                 605             


Arg Asp Asn Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp 
    610                 615                 620                 


Met Leu Asp Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu 
625                 630                 635                 640 


Tyr Ser Met Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu 
                645                 650                 655     


Leu Lys Leu Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro 
            660                 665                 670         


Glu Ala Ala Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala 
        675                 680                 685             


Arg Val Glu Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro 
    690                 695                 700                 


Asp Ala Asp Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
705                 710                 715                 720 


Asp Glu Asp Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln 
                725                 730                 735     


Arg Gln Gln Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu 
            740                 745                 750         


Met Thr Asp Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile 
        755                 760                 765             


Leu Gly Leu Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys 
    770                 775                 780                 


Lys Ala Met Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile 
785                 790                 795                 800 


Leu Ala Thr Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr 
                805                 810                 815     


Lys Glu Asp Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr 
            820                 825                 830         


Ser Gly His Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg 
        835                 840                 845             


Glu Glu Gly Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val 
    850                 855                 860                 


Ala Ala Glu Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr 
865                 870                 875                 880 


Ser Leu Glu Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro 
                885                 890                 895     


His Leu Arg Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp 
            900                 905                 910         


Val Glu His Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala 
        915                 920                 925             


Phe Val Ala Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala 
    930                 935                 940                 


Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr 
945                 950                 955                 960 


Leu Thr Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile 
                965                 970                 975     


Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile 
            980                 985                 990         


Glu Gly Asp Thr Ser Gly Asp Phe  Leu Lys Ala Leu Leu  Ala Leu Cys 
        995                 1000                 1005             


Gly Gly  Glu Asp 
    1010         


<210>  63
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser 
                325                 330                 335     


Ile His Asp Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu 
            340                 345                 350         


Tyr Thr Ala Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp 
        355                 360                 365             


Ile Ile Thr Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser 
    370                 375                 380                 


Tyr Lys Ser Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu 
385                 390                 395                 400 


Leu Thr Gly Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro 
                405                 410                 415     


Ala Tyr Cys Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly 
            420                 425                 430         


Thr Asp Glu Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu 
        435                 440                 445             


Gln Met His Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp 
    450                 455                 460                 


Leu Glu Ala Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met 
465                 470                 475                 480 


Leu Val Val Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser 
                485                 490                 495     


Glu Asp Leu Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu 
            500                 505                 510         


Leu Lys Trp Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn 
        515                 520                 525             


Arg Ser Lys Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr 
    530                 535                 540                 


Thr Gly Lys Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp 
545                 550                 555                 560 


Phe Glu Lys Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro 
                565                 570                 575     


Glu Tyr Phe Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr 
            580                 585                 590         


Arg Asp Asn Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp 
        595                 600                 605             


Met Leu Asp Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu 
    610                 615                 620                 


Tyr Ser Met Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu 
625                 630                 635                 640 


Leu Lys Leu Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro 
                645                 650                 655     


Glu Ala Ala Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala 
            660                 665                 670         


Arg Val Glu Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro 
        675                 680                 685             


Asp Ala Asp Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
    690                 695                 700                 


Asp Glu Asp Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln 
705                 710                 715                 720 


Arg Gln Gln Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu 
                725                 730                 735     


Met Thr Asp Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile 
            740                 745                 750         


Leu Gly Leu Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys 
        755                 760                 765             


Lys Ala Met Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile 
    770                 775                 780                 


Leu Ala Thr Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr 
785                 790                 795                 800 


Lys Glu Asp Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr 
                805                 810                 815     


Ser Gly His Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg 
            820                 825                 830         


Glu Glu Gly Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val 
        835                 840                 845             


Ala Ala Glu Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr 
    850                 855                 860                 


Ser Leu Glu Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro 
865                 870                 875                 880 


His Leu Arg Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp 
                885                 890                 895     


Val Glu His Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala 
            900                 905                 910         


Phe Val Ala Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala 
        915                 920                 925             


Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr 
    930                 935                 940                 


Leu Thr Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile 
945                 950                 955                 960 


Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile 
                965                 970                 975     


Glu Gly Asp Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys 
            980                 985                 990         


Gly Gly Glu Asp 
        995     


<210>  64
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly 
        675                 680                 685             


Phe Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly 
    690                 695                 700                 


Leu Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn 
705                 710                 715                 720 


Thr Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly 
                725                 730                 735     


Arg Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
            740                 745                 750         


Gln Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln 
        755                 760                 765             


Glu Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu 
    770                 775                 780                 


Ile Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser 
785                 790                 795                 800 


Gln Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg 
                805                 810                 815     


Ser Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala 
            820                 825                 830         


Gly Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln 
        835                 840                 845             


Asp Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp 
    850                 855                 860                 


Glu Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu 
865                 870                 875                 880 


Leu His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu 
                885                 890                 895     


Gln Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu 
            900                 905                 910         


Ala Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys 
        915                 920                 925             


Leu Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile 
    930                 935                 940                 


Arg Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala 
945                 950                 955                 960 


His Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly 
                965                 970                 975     


Asp Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly 
            980                 985                 990         


Asp Asp 
        


<210>  65
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
                325                 330                 335     


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            340                 345                 350         


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        355                 360                 365             


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    370                 375                 380                 


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
385                 390                 395                 400 


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                405                 410                 415     


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            420                 425                 430         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        435                 440                 445             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    450                 455                 460                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
465                 470                 475                 480 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                485                 490                 495     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            500                 505                 510         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        515                 520                 525             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    530                 535                 540                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
545                 550                 555                 560 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                565                 570                 575     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            580                 585                 590         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        595                 600                 605             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    610                 615                 620                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
625                 630                 635                 640 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                645                 650                 655     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            660                 665                 670         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        675                 680                 685             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    690                 695                 700                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
705                 710                 715                 720 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                725                 730                 735     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            740                 745                 750         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        755                 760                 765             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    770                 775                 780                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
785                 790                 795                 800 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                805                 810                 815     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            820                 825                 830         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        835                 840                 845             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    850                 855                 860                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
865                 870                 875                 880 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                885                 890                 895     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            900                 905                 910         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        915                 920                 925             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    930                 935                 940                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
945                 950                 955                 960 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                965                 970                 975     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            980                 985                 990         


Asp 
    


<210>  66
<211>  1346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His 
        675                 680                 685             


Asp Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr 
    690                 695                 700                 


Ala Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile 
705                 710                 715                 720 


Thr Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys 
                725                 730                 735     


Ser Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr 
            740                 745                 750         


Gly Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr 
        755                 760                 765             


Cys Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp 
    770                 775                 780                 


Glu Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met 
785                 790                 795                 800 


His Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu 
                805                 810                 815     


Ala Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val 
            820                 825                 830         


Val Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp 
        835                 840                 845             


Leu Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys 
    850                 855                 860                 


Trp Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser 
865                 870                 875                 880 


Lys Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly 
                885                 890                 895     


Lys Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu 
            900                 905                 910         


Lys Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr 
        915                 920                 925             


Phe Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp 
    930                 935                 940                 


Asn Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu 
945                 950                 955                 960 


Asp Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser 
                965                 970                 975     


Met Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys 
            980                 985                 990         


Leu Ser Gly Gly Asp Asp Asp Ala  Ala Gly Gln Phe Phe  Pro Glu Ala 
        995                 1000                 1005             


Ala Gln  Val Ala Tyr Gln Met  Trp Glu Leu Ser Ala  Val Ala Arg 
    1010                 1015                 1020             


Val Glu  Leu Lys Gly Thr Val  Arg Pro Ala Asn Asp  Phe Asn Pro 
    1025                 1030                 1035             


Asp Ala  Asp Ala Lys Ala Leu  Arg Lys Ala Met Lys  Gly Leu Gly 
    1040                 1045                 1050             


Thr Asp  Glu Asp Thr Ile Ile  Asp Ile Ile Thr His  Arg Ser Asn 
    1055                 1060                 1065             


Val Gln  Arg Gln Gln Ile Arg  Gln Thr Phe Lys Ser  His Phe Gly 
    1070                 1075                 1080             


Arg Asp  Leu Met Thr Asp Leu  Lys Ser Glu Ile Ser  Gly Asp Leu 
    1085                 1090                 1095             


Ala Arg  Leu Ile Leu Gly Leu  Met Met Pro Pro Ala  His Tyr Asp 
    1100                 1105                 1110             


Ala Lys  Gln Leu Lys Lys Ala  Met Glu Gly Ala Gly  Thr Asp Glu 
    1115                 1120                 1125             


Lys Ala  Leu Ile Glu Ile Leu  Ala Thr Arg Thr Asn  Ala Glu Ile 
    1130                 1135                 1140             


Arg Ala  Ile Asn Glu Ala Tyr  Lys Glu Asp Tyr His  Lys Ser Leu 
    1145                 1150                 1155             


Glu Asp  Ala Leu Ser Ser Asp  Thr Ser Gly His Phe  Arg Arg Ile 
    1160                 1165                 1170             


Leu Ile  Ser Leu Ala Thr Gly  His Arg Glu Glu Gly  Gly Glu Asn 
    1175                 1180                 1185             


Leu Asp  Gln Ala Arg Glu Asp  Ala Gln Val Ala Ala  Glu Ile Leu 
    1190                 1195                 1200             


Glu Ile  Ala Asp Thr Pro Ser  Gly Asp Lys Thr Ser  Leu Glu Thr 
    1205                 1210                 1215             


Arg Phe  Met Thr Ile Leu Cys  Thr Arg Ser Tyr Pro  His Leu Arg 
    1220                 1225                 1230             


Arg Val  Phe Gln Glu Phe Ile  Lys Met Thr Asn Tyr  Asp Val Glu 
    1235                 1240                 1245             


His Thr  Ile Lys Lys Glu Met  Ser Gly Asp Val Arg  Asp Ala Phe 
    1250                 1255                 1260             


Val Ala  Ile Val Gln Ser Val  Lys Asn Lys Pro Leu  Phe Phe Ala 
    1265                 1270                 1275             


Asp Lys  Leu Tyr Lys Ser Met  Lys Gly Ala Gly Thr  Asp Glu Lys 
    1280                 1285                 1290             


Thr Leu  Thr Arg Ile Met Val  Ser Arg Ser Glu Ile  Asp Leu Leu 
    1295                 1300                 1305             


Asn Ile  Arg Arg Glu Phe Ile  Glu Lys Tyr Asp Lys  Ser Leu His 
    1310                 1315                 1320             


Gln Ala  Ile Glu Gly Asp Thr  Ser Gly Asp Phe Leu  Lys Ala Leu 
    1325                 1330                 1335             


Leu Ala  Leu Cys Gly Gly Glu  Asp 
    1340                 1345     


<210>  67
<211>  1139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile 
465                 470                 475                 480 


His Asp Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr 
                485                 490                 495     


Thr Ala Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile 
            500                 505                 510         


Ile Thr Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr 
        515                 520                 525             


Lys Ser Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu 
    530                 535                 540                 


Thr Gly Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala 
545                 550                 555                 560 


Tyr Cys Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr 
                565                 570                 575     


Asp Glu Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln 
            580                 585                 590         


Met His Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu 
        595                 600                 605             


Glu Ala Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu 
    610                 615                 620                 


Val Val Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu 
625                 630                 635                 640 


Asp Leu Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu 
                645                 650                 655     


Lys Trp Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg 
            660                 665                 670         


Ser Lys Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr 
        675                 680                 685             


Gly Lys Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe 
    690                 695                 700                 


Glu Lys Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu 
705                 710                 715                 720 


Tyr Phe Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg 
                725                 730                 735     


Asp Asn Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met 
            740                 745                 750         


Leu Asp Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr 
        755                 760                 765             


Ser Met Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu 
    770                 775                 780                 


Lys Leu Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu 
785                 790                 795                 800 


Ala Ala Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg 
                805                 810                 815     


Val Glu Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp 
            820                 825                 830         


Ala Asp Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp 
        835                 840                 845             


Glu Asp Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg 
    850                 855                 860                 


Gln Gln Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met 
865                 870                 875                 880 


Thr Asp Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu 
                885                 890                 895     


Gly Leu Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys 
            900                 905                 910         


Ala Met Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu 
        915                 920                 925             


Ala Thr Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys 
    930                 935                 940                 


Glu Asp Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser 
945                 950                 955                 960 


Gly His Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu 
                965                 970                 975     


Glu Gly Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala 
            980                 985                 990         


Ala Glu Ile Leu Glu Ile Ala Asp  Thr Pro Ser Gly Asp  Lys Thr Ser 
        995                 1000                 1005             


Leu Glu  Thr Arg Phe Met Thr  Ile Leu Cys Thr Arg  Ser Tyr Pro 
    1010                 1015                 1020             


His Leu  Arg Arg Val Phe Gln  Glu Phe Ile Lys Met  Thr Asn Tyr 
    1025                 1030                 1035             


Asp Val  Glu His Thr Ile Lys  Lys Glu Met Ser Gly  Asp Val Arg 
    1040                 1045                 1050             


Asp Ala  Phe Val Ala Ile Val  Gln Ser Val Lys Asn  Lys Pro Leu 
    1055                 1060                 1065             


Phe Phe  Ala Asp Lys Leu Tyr  Lys Ser Met Lys Gly  Ala Gly Thr 
    1070                 1075                 1080             


Asp Glu  Lys Thr Leu Thr Arg  Ile Met Val Ser Arg  Ser Glu Ile 
    1085                 1090                 1095             


Asp Leu  Leu Asn Ile Arg Arg  Glu Phe Ile Glu Lys  Tyr Asp Lys 
    1100                 1105                 1110             


Ser Leu  His Gln Ala Ile Glu  Gly Asp Thr Ser Gly  Asp Phe Leu 
    1115                 1120                 1125             


Lys Ala  Leu Leu Ala Leu Cys  Gly Gly Glu Asp 
    1130                 1135                 


<210>  68
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Lys Pro Ala Gln Gly Ala Lys 
                325                 330                 335     


Tyr Arg Gly Ser Ile His Asp Phe Pro Gly Phe Asp Pro Asn Gln Asp 
            340                 345                 350         


Ala Glu Ala Leu Tyr Thr Ala Met Lys Gly Phe Gly Ser Asp Lys Glu 
        355                 360                 365             


Ala Ile Leu Asp Ile Ile Thr Ser Arg Ser Asn Arg Gln Arg Gln Glu 
    370                 375                 380                 


Val Cys Gln Ser Tyr Lys Ser Leu Tyr Gly Lys Asp Leu Ile Ala Asp 
385                 390                 395                 400 


Leu Lys Tyr Glu Leu Thr Gly Lys Phe Glu Arg Leu Ile Val Gly Leu 
                405                 410                 415     


Met Arg Pro Pro Ala Tyr Cys Asp Ala Lys Glu Ile Lys Asp Ala Ile 
            420                 425                 430         


Ser Gly Ile Gly Thr Asp Glu Lys Cys Leu Ile Glu Ile Leu Ala Ser 
        435                 440                 445             


Arg Thr Asn Glu Gln Met His Gln Leu Val Ala Ala Tyr Lys Asp Ala 
    450                 455                 460                 


Tyr Glu Arg Asp Leu Glu Ala Asp Ile Ile Gly Asp Thr Ser Gly His 
465                 470                 475                 480 


Phe Gln Lys Met Leu Val Val Leu Leu Gln Gly Thr Arg Glu Glu Asp 
                485                 490                 495     


Asp Val Val Ser Glu Asp Leu Val Gln Gln Asp Val Gln Asp Leu Tyr 
            500                 505                 510         


Glu Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Ala Gln Phe Ile Tyr 
        515                 520                 525             


Ile Leu Gly Asn Arg Ser Lys Gln His Leu Arg Leu Val Phe Asp Glu 
    530                 535                 540                 


Tyr Leu Lys Thr Thr Gly Lys Pro Ile Glu Ala Ser Ile Arg Gly Glu 
545                 550                 555                 560 


Leu Ser Gly Asp Phe Glu Lys Leu Met Leu Ala Val Val Lys Cys Ile 
                565                 570                 575     


Arg Ser Thr Pro Glu Tyr Phe Ala Glu Arg Leu Phe Lys Ala Met Lys 
            580                 585                 590         


Gly Leu Gly Thr Arg Asp Asn Thr Leu Ile Arg Ile Met Val Ser Arg 
        595                 600                 605             


Ser Glu Leu Asp Met Leu Asp Ile Arg Glu Ile Phe Arg Thr Lys Tyr 
    610                 615                 620                 


Glu Lys Ser Leu Tyr Ser Met Ile Lys Asn Asp Thr Ser Gly Glu Tyr 
625                 630                 635                 640 


Lys Lys Thr Leu Leu Lys Leu Ser Gly Gly Asp Asp Asp Ala Ala Gly 
                645                 650                 655     


Gln Phe Phe Pro Glu Ala Ala Gln Val Ala Tyr Gln Met Trp Glu Leu 
            660                 665                 670         


Ser Ala Val Ala Arg Val Glu Leu Lys Gly Thr Val Arg Pro Ala Asn 
        675                 680                 685             


Asp Phe Asn Pro Asp Ala Asp Ala Lys Ala Leu Arg Lys Ala Met Lys 
    690                 695                 700                 


Gly Leu Gly Thr Asp Glu Asp Thr Ile Ile Asp Ile Ile Thr His Arg 
705                 710                 715                 720 


Ser Asn Val Gln Arg Gln Gln Ile Arg Gln Thr Phe Lys Ser His Phe 
                725                 730                 735     


Gly Arg Asp Leu Met Thr Asp Leu Lys Ser Glu Ile Ser Gly Asp Leu 
            740                 745                 750         


Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro Ala His Tyr Asp Ala 
        755                 760                 765             


Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly Thr Asp Glu Lys Ala 
    770                 775                 780                 


Leu Ile Glu Ile Leu Ala Thr Arg Thr Asn Ala Glu Ile Arg Ala Ile 
785                 790                 795                 800 


Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser Leu Glu Asp Ala Leu 
                805                 810                 815     


Ser Ser Asp Thr Ser Gly His Phe Arg Arg Ile Leu Ile Ser Leu Ala 
            820                 825                 830         


Thr Gly His Arg Glu Glu Gly Gly Glu Asn Leu Asp Gln Ala Arg Glu 
        835                 840                 845             


Asp Ala Gln Val Ala Ala Glu Ile Leu Glu Ile Ala Asp Thr Pro Ser 
    850                 855                 860                 


Gly Asp Lys Thr Ser Leu Glu Thr Arg Phe Met Thr Ile Leu Cys Thr 
865                 870                 875                 880 


Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Glu Phe Ile Lys Met 
                885                 890                 895     


Thr Asn Tyr Asp Val Glu His Thr Ile Lys Lys Glu Met Ser Gly Asp 
            900                 905                 910         


Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser Val Lys Asn Lys Pro 
        915                 920                 925             


Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr 
    930                 935                 940                 


Asp Glu Lys Thr Leu Thr Arg Ile Met Val Ser Arg Ser Glu Ile Asp 
945                 950                 955                 960 


Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu 
                965                 970                 975     


His Gln Ala Ile Glu Gly Asp Thr Ser Gly Asp Phe Leu Lys Ala Leu 
            980                 985                 990         


Leu Ala Leu Cys Gly Gly Glu Asp  
        995                 1000 


<210>  69
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Lys Pro Ala Gln Gly 
            500                 505                 510         


Ala Lys Tyr Arg Gly Ser Ile His Asp Phe Pro Gly Phe Asp Pro Asn 
        515                 520                 525             


Gln Asp Ala Glu Ala Leu Tyr Thr Ala Met Lys Gly Phe Gly Ser Asp 
    530                 535                 540                 


Lys Glu Ala Ile Leu Asp Ile Ile Thr Ser Arg Ser Asn Arg Gln Arg 
545                 550                 555                 560 


Gln Glu Val Cys Gln Ser Tyr Lys Ser Leu Tyr Gly Lys Asp Leu Ile 
                565                 570                 575     


Ala Asp Leu Lys Tyr Glu Leu Thr Gly Lys Phe Glu Arg Leu Ile Val 
            580                 585                 590         


Gly Leu Met Arg Pro Pro Ala Tyr Cys Asp Ala Lys Glu Ile Lys Asp 
        595                 600                 605             


Ala Ile Ser Gly Ile Gly Thr Asp Glu Lys Cys Leu Ile Glu Ile Leu 
    610                 615                 620                 


Ala Ser Arg Thr Asn Glu Gln Met His Gln Leu Val Ala Ala Tyr Lys 
625                 630                 635                 640 


Asp Ala Tyr Glu Arg Asp Leu Glu Ala Asp Ile Ile Gly Asp Thr Ser 
                645                 650                 655     


Gly His Phe Gln Lys Met Leu Val Val Leu Leu Gln Gly Thr Arg Glu 
            660                 665                 670         


Glu Asp Asp Val Val Ser Glu Asp Leu Val Gln Gln Asp Val Gln Asp 
        675                 680                 685             


Leu Tyr Glu Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Ala Gln Phe 
    690                 695                 700                 


Ile Tyr Ile Leu Gly Asn Arg Ser Lys Gln His Leu Arg Leu Val Phe 
705                 710                 715                 720 


Asp Glu Tyr Leu Lys Thr Thr Gly Lys Pro Ile Glu Ala Ser Ile Arg 
                725                 730                 735     


Gly Glu Leu Ser Gly Asp Phe Glu Lys Leu Met Leu Ala Val Val Lys 
            740                 745                 750         


Cys Ile Arg Ser Thr Pro Glu Tyr Phe Ala Glu Arg Leu Phe Lys Ala 
        755                 760                 765             


Met Lys Gly Leu Gly Thr Arg Asp Asn Thr Leu Ile Arg Ile Met Val 
    770                 775                 780                 


Ser Arg Ser Glu Leu Asp Met Leu Asp Ile Arg Glu Ile Phe Arg Thr 
785                 790                 795                 800 


Lys Tyr Glu Lys Ser Leu Tyr Ser Met Ile Lys Asn Asp Thr Ser Gly 
                805                 810                 815     


Glu Tyr Lys Lys Thr Leu Leu Lys Leu Ser Gly Gly Asp Asp Asp Ala 
            820                 825                 830         


Ala Gly Gln Phe Phe Pro Glu Ala Ala Gln Val Ala Tyr Gln Met Trp 
        835                 840                 845             


Glu Leu Ser Ala Val Ala Arg Val Glu Leu Lys Gly Thr Val Arg Pro 
    850                 855                 860                 


Ala Asn Asp Phe Asn Pro Asp Ala Asp Ala Lys Ala Leu Arg Lys Ala 
865                 870                 875                 880 


Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Ile Ile Asp Ile Ile Thr 
                885                 890                 895     


His Arg Ser Asn Val Gln Arg Gln Gln Ile Arg Gln Thr Phe Lys Ser 
            900                 905                 910         


His Phe Gly Arg Asp Leu Met Thr Asp Leu Lys Ser Glu Ile Ser Gly 
        915                 920                 925             


Asp Leu Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro Ala His Tyr 
    930                 935                 940                 


Asp Ala Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly Thr Asp Glu 
945                 950                 955                 960 


Lys Ala Leu Ile Glu Ile Leu Ala Thr Arg Thr Asn Ala Glu Ile Arg 
                965                 970                 975     


Ala Ile Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser Leu Glu Asp 
            980                 985                 990         


Ala Leu Ser Ser Asp Thr Ser Gly  His Phe Arg Arg Ile  Leu Ile Ser 
        995                 1000                 1005             


Leu Ala  Thr Gly His Arg Glu  Glu Gly Gly Glu Asn  Leu Asp Gln 
    1010                 1015                 1020             


Ala Arg  Glu Asp Ala Gln Val  Ala Ala Glu Ile Leu  Glu Ile Ala 
    1025                 1030                 1035             


Asp Thr  Pro Ser Gly Asp Lys  Thr Ser Leu Glu Thr  Arg Phe Met 
    1040                 1045                 1050             


Thr Ile  Leu Cys Thr Arg Ser  Tyr Pro His Leu Arg  Arg Val Phe 
    1055                 1060                 1065             


Gln Glu  Phe Ile Lys Met Thr  Asn Tyr Asp Val Glu  His Thr Ile 
    1070                 1075                 1080             


Lys Lys  Glu Met Ser Gly Asp  Val Arg Asp Ala Phe  Val Ala Ile 
    1085                 1090                 1095             


Val Gln  Ser Val Lys Asn Lys  Pro Leu Phe Phe Ala  Asp Lys Leu 
    1100                 1105                 1110             


Tyr Lys  Ser Met Lys Gly Ala  Gly Thr Asp Glu Lys  Thr Leu Thr 
    1115                 1120                 1125             


Arg Ile  Met Val Ser Arg Ser  Glu Ile Asp Leu Leu  Asn Ile Arg 
    1130                 1135                 1140             


Arg Glu  Phe Ile Glu Lys Tyr  Asp Lys Ser Leu His  Gln Ala Ile 
    1145                 1150                 1155             


Glu Gly  Asp Thr Ser Gly Asp  Phe Leu Lys Ala Leu  Leu Ala Leu 
    1160                 1165                 1170             


Cys Gly  Gly Glu Asp 
    1175             


<210>  70
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Lys Pro 
305                 310                 315                 320 


Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp Phe Pro Gly Phe 
                325                 330                 335     


Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala Met Lys Gly Phe 
            340                 345                 350         


Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr Ser Arg Ser Asn 
        355                 360                 365             


Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser Leu Tyr Gly Lys 
    370                 375                 380                 


Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly Lys Phe Glu Arg 
385                 390                 395                 400 


Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys Asp Ala Lys Glu 
                405                 410                 415     


Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu Lys Cys Leu Ile 
            420                 425                 430         


Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His Gln Leu Val Ala 
        435                 440                 445             


Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala Asp Ile Ile Gly 
    450                 455                 460                 


Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val Leu Leu Gln Gly 
465                 470                 475                 480 


Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu Val Gln Gln Asp 
                485                 490                 495     


Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu 
            500                 505                 510         


Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys Gln His Leu Arg 
        515                 520                 525             


Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys Pro Ile Glu Ala 
    530                 535                 540                 


Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys Leu Met Leu Ala 
545                 550                 555                 560 


Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe Ala Glu Arg Leu 
                565                 570                 575     


Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn Thr Leu Ile Arg 
            580                 585                 590         


Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp Ile Arg Glu Ile 
        595                 600                 605             


Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met Ile Lys Asn Asp 
    610                 615                 620                 


Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu Ser Gly Gly Asp 
625                 630                 635                 640 


Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala Gln Val Ala Tyr 
                645                 650                 655     


Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu Leu Lys Gly Thr 
            660                 665                 670         


Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp Ala Lys Ala Leu 
        675                 680                 685             


Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Ile Ile Asp 
    690                 695                 700                 


Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln Ile Arg Gln Thr 
705                 710                 715                 720 


Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp Leu Lys Ser Glu 
                725                 730                 735     


Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro 
            740                 745                 750         


Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly 
        755                 760                 765             


Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr Arg Thr Asn Ala 
    770                 775                 780                 


Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser 
785                 790                 795                 800 


Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His Phe Arg Arg Ile 
                805                 810                 815     


Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly Gly Glu Asn Leu 
            820                 825                 830         


Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu Ile Leu Glu Ile 
        835                 840                 845             


Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu Thr Arg Phe Met 
    850                 855                 860                 


Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln 
865                 870                 875                 880 


Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His Thr Ile Lys Lys 
                885                 890                 895     


Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser 
            900                 905                 910         


Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met 
        915                 920                 925             


Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg Ile Met Val Ser 
    930                 935                 940                 


Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys 
945                 950                 955                 960 


Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp Thr Ser Gly Asp 
                965                 970                 975     


Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu Asp 
            980                 985                 


<210>  71
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ser Tyr Pro Gly Tyr 
            340                 345                 350         


Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly Tyr Pro Pro Ala Gly Gln 
        355                 360                 365             


Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr Pro Tyr Pro Ser Gly Phe 
    370                 375                 380                 


Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln Val Pro Ser Ser Gly Tyr 
385                 390                 395                 400 


Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Ala Pro Gly 
                405                 410                 415     


Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly Ala Pro Ser Tyr Pro Gly 
            420                 425                 430         


Val Pro Pro Gly Gln Gly Phe Gly Val Pro Pro Gly Gly Ala Gly Phe 
        435                 440                 445             


Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser Tyr Gly Gly Gly Pro Ala 
    450                 455                 460                 


Gln Val Pro Leu Pro Gly Gly Phe Pro Gly Gly Gln Met Pro Ser Gln 
465                 470                 475                 480 


Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser Gln Pro Ala Thr Val Thr 
                485                 490                 495     


Gln Val Thr Gln Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile 
            500                 505                 510         


Arg Asp Ala Glu Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp 
        515                 520                 525             


Glu Gln Ala Ile Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg 
    530                 535                 540                 


Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile 
545                 550                 555                 560 


Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu 
                565                 570                 575     


Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys 
            580                 585                 590         


Ala Met Gln Gly Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu 
        595                 600                 605             


Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln 
    610                 615                 620                 


Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser 
625                 630                 635                 640 


Gly His Phe Glu Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp 
                645                 650                 655     


Glu Asn Gln Ser Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg 
            660                 665                 670         


Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe 
        675                 680                 685             


Asn Met Ile Leu Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met 
    690                 695                 700                 


Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser 
705                 710                 715                 720 


Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln 
                725                 730                 735     


Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala 
            740                 745                 750         


Met Lys Gly Ala Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val 
        755                 760                 765             


Thr Arg Ser Glu Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln 
    770                 775                 780                 


Met Tyr Gln Lys Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly 
785                 790                 795                 800 


Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val Gly Gln 
                805                 810         


<210>  72
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro 
            340                 345                 350         


Phe Pro Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser 
        355                 360                 365             


Gly Gln Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala 
    370                 375                 380                 


Tyr Pro Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro 
385                 390                 395                 400 


Ala Pro Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln 
                405                 410                 415     


Pro Gly Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe 
            420                 425                 430         


Gly Val Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro 
        435                 440                 445             


Ser Gln Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly 
    450                 455                 460                 


Phe Pro Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr 
465                 470                 475                 480 


Tyr Pro Ser Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile 
                485                 490                 495     


Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg 
            500                 505                 510         


Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val 
        515                 520                 525             


Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe 
    530                 535                 540                 


Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu 
545                 550                 555                 560 


Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr 
                565                 570                 575     


Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr 
            580                 585                 590         


Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu 
        595                 600                 605             


Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu 
    610                 615                 620                 


Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu 
625                 630                 635                 640 


Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His 
                645                 650                 655     


Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly 
            660                 665                 670         


Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg 
        675                 680                 685             


Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala 
    690                 695                 700                 


Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val 
705                 710                 715                 720 


Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala 
                725                 730                 735     


Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp 
            740                 745                 750         


Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu 
        755                 760                 765             


Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly 
    770                 775                 780                 


Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu 
785                 790                 795                 800 


Ala Ile Val Gly Gln 
                805 


<210>  73
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro 
                325                 330                 335     


Phe Pro Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser 
            340                 345                 350         


Gly Gln Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala 
        355                 360                 365             


Tyr Pro Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro 
    370                 375                 380                 


Ala Pro Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln 
385                 390                 395                 400 


Pro Gly Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe 
                405                 410                 415     


Gly Val Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro 
            420                 425                 430         


Ser Gln Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly 
        435                 440                 445             


Phe Pro Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr 
    450                 455                 460                 


Tyr Pro Ser Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile 
465                 470                 475                 480 


Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg 
                485                 490                 495     


Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val 
            500                 505                 510         


Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe 
        515                 520                 525             


Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu 
    530                 535                 540                 


Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr 
545                 550                 555                 560 


Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr 
                565                 570                 575     


Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu 
            580                 585                 590         


Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu 
        595                 600                 605             


Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu 
    610                 615                 620                 


Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His 
625                 630                 635                 640 


Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly 
                645                 650                 655     


Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg 
            660                 665                 670         


Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala 
        675                 680                 685             


Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val 
    690                 695                 700                 


Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala 
705                 710                 715                 720 


Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp 
                725                 730                 735     


Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu 
            740                 745                 750         


Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly 
        755                 760                 765             


Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu 
    770                 775                 780                 


Ala Ile Val Gly Gln 
785                 


<210>  74
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro 
                325                 330                 335     


Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln 
            340                 345                 350         


Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro 
        355                 360                 365             


Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro 
    370                 375                 380                 


Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly 
385                 390                 395                 400 


Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val 
                405                 410                 415     


Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln 
            420                 425                 430         


Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro 
        435                 440                 445             


Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro 
    450                 455                 460                 


Ser Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro 
465                 470                 475                 480 


Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala 
                485                 490                 495     


Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala 
            500                 505                 510         


Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr 
        515                 520                 525             


Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly 
    530                 535                 540                 


Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr 
545                 550                 555                 560 


Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu 
                565                 570                 575     


Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg 
            580                 585                 590         


Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys 
        595                 600                 605             


Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser 
    610                 615                 620                 


Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met 
625                 630                 635                 640 


Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu 
                645                 650                 655     


Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe 
            660                 665                 670         


Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg 
        675                 680                 685             


Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser 
    690                 695                 700                 


Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe 
705                 710                 715                 720 


Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser 
                725                 730                 735     


Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln 
            740                 745                 750         


Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met 
        755                 760                 765             


Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile 
    770                 775                 780                 


Val Gly Gln 
785         


<210>  75
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
                325                 330                 335     


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            340                 345                 350         


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        355                 360                 365             


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    370                 375                 380                 


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
385                 390                 395                 400 


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                405                 410                 415     


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            420                 425                 430         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        435                 440                 445             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    450                 455                 460                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
465                 470                 475                 480 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                485                 490                 495     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            500                 505                 510         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        515                 520                 525             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    530                 535                 540                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
545                 550                 555                 560 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                565                 570                 575     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            580                 585                 590         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        595                 600                 605             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    610                 615                 620                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
625                 630                 635                 640 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                645                 650                 655     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            660                 665                 670         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        675                 680                 685             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    690                 695                 700                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
705                 710                 715                 720 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                725                 730                 735     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            740                 745                 750         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        755                 760                 765             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    770                 775                 780                 


Gly Gln 
785     


<210>  76
<211>  1139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro 
        675                 680                 685             


Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln 
    690                 695                 700                 


Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro 
705                 710                 715                 720 


Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro 
                725                 730                 735     


Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly 
            740                 745                 750         


Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val 
        755                 760                 765             


Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln 
    770                 775                 780                 


Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro 
785                 790                 795                 800 


Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro 
                805                 810                 815     


Ser Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro 
            820                 825                 830         


Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala 
        835                 840                 845             


Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala 
    850                 855                 860                 


Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr 
865                 870                 875                 880 


Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly 
                885                 890                 895     


Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr 
            900                 905                 910         


Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu 
        915                 920                 925             


Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg 
    930                 935                 940                 


Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys 
945                 950                 955                 960 


Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser 
                965                 970                 975     


Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met 
            980                 985                 990         


Ala Gln Glu Asp Ala Gln Arg Leu  Tyr Gln Ala Gly Glu  Gly Arg Leu 
        995                 1000                 1005             


Gly Thr  Asp Glu Ser Cys Phe  Asn Met Ile Leu Ala  Thr Arg Ser 
    1010                 1015                 1020             


Phe Pro  Gln Leu Arg Ala Thr  Met Glu Ala Tyr Ser  Arg Met Ala 
    1025                 1030                 1035             


Asn Arg  Asp Leu Leu Ser Ser  Val Ser Arg Glu Phe  Ser Gly Tyr 
    1040                 1045                 1050             


Val Glu  Ser Gly Leu Lys Thr  Ile Leu Gln Cys Ala  Leu Asn Arg 
    1055                 1060                 1065             


Pro Ala  Phe Phe Ala Glu Arg  Leu Tyr Tyr Ala Met  Lys Gly Ala 
    1070                 1075                 1080             


Gly Thr  Asp Asp Ser Thr Leu  Val Arg Ile Val Val  Thr Arg Ser 
    1085                 1090                 1095             


Glu Ile  Asp Leu Val Gln Ile  Lys Gln Met Phe Ala  Gln Met Tyr 
    1100                 1105                 1110             


Gln Lys  Thr Leu Gly Thr Met  Ile Ala Gly Asp Thr  Ser Gly Asp 
    1115                 1120                 1125             


Tyr Arg  Arg Leu Leu Leu Ala  Ile Val Gly Gln 
    1130                 1135                 


<210>  77
<211>  932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe 
465                 470                 475                 480 


Pro Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly 
                485                 490                 495     


Gln Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr 
            500                 505                 510         


Pro Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala 
        515                 520                 525             


Pro Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro 
    530                 535                 540                 


Gly Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly 
545                 550                 555                 560 


Val Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser 
                565                 570                 575     


Gln Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe 
            580                 585                 590         


Pro Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr 
        595                 600                 605             


Pro Ser Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg 
    610                 615                 620                 


Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys 
625                 630                 635                 640 


Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val 
                645                 650                 655     


Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys 
            660                 665                 670         


Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser 
        675                 680                 685             


Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr 
    690                 695                 700                 


Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln 
705                 710                 715                 720 


Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile 
                725                 730                 735     


Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu 
            740                 745                 750         


Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val 
        755                 760                 765             


Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln 
    770                 775                 780                 


Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg 
785                 790                 795                 800 


Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser 
                805                 810                 815     


Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn 
            820                 825                 830         


Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu 
        835                 840                 845             


Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe 
    850                 855                 860                 


Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp 
865                 870                 875                 880 


Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val 
                885                 890                 895     


Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr 
            900                 905                 910         


Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala 
        915                 920                 925             


Ile Val Gly Gln 
    930         


<210>  78
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ser Tyr Pro Gly Tyr Pro Pro Thr 
                325                 330                 335     


Gly Tyr Pro Pro Phe Pro Gly Tyr Pro Pro Ala Gly Gln Glu Ser Ser 
            340                 345                 350         


Phe Pro Pro Ser Gly Gln Tyr Pro Tyr Pro Ser Gly Phe Pro Pro Met 
        355                 360                 365             


Gly Gly Gly Ala Tyr Pro Gln Val Pro Ser Ser Gly Tyr Pro Gly Ala 
    370                 375                 380                 


Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro 
385                 390                 395                 400 


Gly Ala Pro Gln Pro Gly Gly Ala Pro Ser Tyr Pro Gly Val Pro Pro 
                405                 410                 415     


Gly Gln Gly Phe Gly Val Pro Pro Gly Gly Ala Gly Phe Ser Gly Tyr 
            420                 425                 430         


Pro Gln Pro Pro Ser Gln Ser Tyr Gly Gly Gly Pro Ala Gln Val Pro 
        435                 440                 445             


Leu Pro Gly Gly Phe Pro Gly Gly Gln Met Pro Ser Gln Tyr Pro Gly 
    450                 455                 460                 


Gly Gln Pro Thr Tyr Pro Ser Gln Pro Ala Thr Val Thr Gln Val Thr 
465                 470                 475                 480 


Gln Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala 
                485                 490                 495     


Glu Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala 
            500                 505                 510         


Ile Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile 
        515                 520                 525             


Lys Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu 
    530                 535                 540                 


Lys Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe 
545                 550                 555                 560 


Met Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln 
                565                 570                 575     


Gly Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg 
            580                 585                 590         


Thr Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe 
        595                 600                 605             


Gly Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe 
    610                 615                 620                 


Glu Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln 
625                 630                 635                 640 


Ser Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln 
                645                 650                 655     


Ala Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile 
            660                 665                 670         


Leu Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr 
        675                 680                 685             


Ser Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe 
    690                 695                 700                 


Ser Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu 
705                 710                 715                 720 


Asn Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly 
                725                 730                 735     


Ala Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser 
            740                 745                 750         


Glu Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln 
        755                 760                 765             


Lys Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg 
    770                 775                 780                 


Arg Leu Leu Leu Ala Ile Val Gly Gln 
785                 790             


<210>  79
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ser Tyr Pro Gly Tyr Pro 
            500                 505                 510         


Pro Thr Gly Tyr Pro Pro Phe Pro Gly Tyr Pro Pro Ala Gly Gln Glu 
        515                 520                 525             


Ser Ser Phe Pro Pro Ser Gly Gln Tyr Pro Tyr Pro Ser Gly Phe Pro 
    530                 535                 540                 


Pro Met Gly Gly Gly Ala Tyr Pro Gln Val Pro Ser Ser Gly Tyr Pro 
545                 550                 555                 560 


Gly Ala Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Ala Pro Gly Gly 
                565                 570                 575     


Tyr Pro Gly Ala Pro Gln Pro Gly Gly Ala Pro Ser Tyr Pro Gly Val 
            580                 585                 590         


Pro Pro Gly Gln Gly Phe Gly Val Pro Pro Gly Gly Ala Gly Phe Ser 
        595                 600                 605             


Gly Tyr Pro Gln Pro Pro Ser Gln Ser Tyr Gly Gly Gly Pro Ala Gln 
    610                 615                 620                 


Val Pro Leu Pro Gly Gly Phe Pro Gly Gly Gln Met Pro Ser Gln Tyr 
625                 630                 635                 640 


Pro Gly Gly Gln Pro Thr Tyr Pro Ser Gln Pro Ala Thr Val Thr Gln 
                645                 650                 655     


Val Thr Gln Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg 
            660                 665                 670         


Asp Ala Glu Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu 
        675                 680                 685             


Gln Ala Ile Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln 
    690                 695                 700                 


Lys Ile Lys Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys 
705                 710                 715                 720 


Asp Leu Lys Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala 
                725                 730                 735     


Leu Phe Met Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala 
            740                 745                 750         


Met Gln Gly Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys 
        755                 760                 765             


Thr Arg Thr Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser 
    770                 775                 780                 


Glu Phe Gly Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly 
785                 790                 795                 800 


His Phe Glu Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu 
                805                 810                 815     


Asn Gln Ser Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu 
            820                 825                 830         


Tyr Gln Ala Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn 
        835                 840                 845             


Met Ile Leu Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu 
    850                 855                 860                 


Ala Tyr Ser Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg 
865                 870                 875                 880 


Glu Phe Ser Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys 
                885                 890                 895     


Ala Leu Asn Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met 
            900                 905                 910         


Lys Gly Ala Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr 
        915                 920                 925             


Arg Ser Glu Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met 
    930                 935                 940                 


Tyr Gln Lys Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp 
945                 950                 955                 960 


Tyr Arg Arg Leu Leu Leu Ala Ile Val Gly Gln 
                965                 970     


<210>  80
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ser Tyr Pro 
305                 310                 315                 320 


Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly Tyr Pro Pro Ala 
                325                 330                 335     


Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr Pro Tyr Pro Ser 
            340                 345                 350         


Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln Val Pro Ser Ser 
        355                 360                 365             


Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Ala 
    370                 375                 380                 


Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly Ala Pro Ser Tyr 
385                 390                 395                 400 


Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro Pro Gly Gly Ala 
                405                 410                 415     


Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser Tyr Gly Gly Gly 
            420                 425                 430         


Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly Gly Gln Met Pro 
        435                 440                 445             


Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser Gln Pro Ala Thr 
    450                 455                 460                 


Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp 
465                 470                 475                 480 


Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met Lys Gly Phe Gly 
                485                 490                 495     


Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn Arg Ser Asn Asp 
            500                 505                 510         


Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp 
        515                 520                 525             


Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn Met Glu Glu Leu 
    530                 535                 540                 


Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu 
545                 550                 555                 560 


Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg Val Leu Ile Glu 
                565                 570                 575     


Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu Ile Val Arg Cys 
            580                 585                 590         


Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp 
        595                 600                 605             


Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met Cys Gln Gly Asn 
    610                 615                 620                 


Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala Gln Glu Asp Ala 
625                 630                 635                 640 


Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser 
                645                 650                 655     


Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala 
            660                 665                 670         


Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp Leu Leu Ser Ser 
        675                 680                 685             


Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile 
    690                 695                 700                 


Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr 
705                 710                 715                 720 


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr Leu Val Arg Ile 
                725                 730                 735     


Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile Lys Gln Met Phe 
            740                 745                 750         


Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile Ala Gly Asp Thr 
        755                 760                 765             


Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val Gly Gln 
    770                 775                 780         


<210>  81
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Met Val Ser Glu Phe Leu Lys 
                325                 330                 335     


Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val 
            340                 345                 350         


Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr 
        355                 360                 365             


Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val 
    370                 375                 380                 


Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn 
385                 390                 395                 400 


Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly 
                405                 410                 415     


Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu 
            420                 425                 430         


Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp 
        435                 440                 445             


Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu 
    450                 455                 460                 


Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn 
465                 470                 475                 480 


Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr 
                485                 490                 495     


Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys 
            500                 505                 510         


Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser 
        515                 520                 525             


Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp 
    530                 535                 540                 


Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu 
545                 550                 555                 560 


Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn 
                565                 570                 575     


Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr 
            580                 585                 590         


Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys 
        595                 600                 605             


Leu His Gln Ala Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile 
    610                 615                 620                 


Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala 
625                 630                 635                 640 


Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp 
                645                 650                 655     


Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly 
            660                 665                 670         


Asn 
    


<210>  82
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val 
            340                 345                 350         


Thr Val Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr 
        355                 360                 365             


Leu Tyr Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile 
    370                 375                 380                 


Asp Val Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys 
385                 390                 395                 400 


Ser Phe Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser 
                405                 410                 415     


Glu Leu Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro 
            420                 425                 430         


Pro Tyr Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu 
        435                 440                 445             


Gly Thr Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys 
    450                 455                 460                 


Asn Gln Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg 
                485                 490                 495     


Ile Leu Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe 
            500                 505                 510         


Val Asp Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala 
        515                 520                 525             


Gly Glu Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu 
    530                 535                 540                 


Cys Thr Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu 
545                 550                 555                 560 


Lys Ile Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His 
                565                 570                 575     


Gly Ser Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn 
            580                 585                 590         


Leu His Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
        595                 600                 605             


Gly Thr Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu 
    610                 615                 620                 


Ile Asp Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys 
625                 630                 635                 640 


Thr Leu Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn 
                645                 650                 655     


Ala Leu Leu Ser Leu Val Gly Ser Asp Pro 
            660                 665     


<210>  83
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val 
                325                 330                 335     


Thr Val Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr 
            340                 345                 350         


Leu Tyr Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile 
        355                 360                 365             


Asp Val Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys 
    370                 375                 380                 


Ser Phe Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser 
385                 390                 395                 400 


Glu Leu Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro 
                405                 410                 415     


Pro Tyr Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu 
            420                 425                 430         


Gly Thr Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys 
        435                 440                 445             


Asn Gln Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser 
    450                 455                 460                 


Ser Leu Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg 
465                 470                 475                 480 


Ile Leu Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe 
                485                 490                 495     


Val Asp Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala 
            500                 505                 510         


Gly Glu Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu 
        515                 520                 525             


Cys Thr Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu 
    530                 535                 540                 


Lys Ile Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His 
545                 550                 555                 560 


Gly Ser Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn 
                565                 570                 575     


Leu His Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            580                 585                 590         


Gly Thr Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu 
        595                 600                 605             


Ile Asp Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys 
    610                 615                 620                 


Thr Leu Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn 
625                 630                 635                 640 


Ala Leu Leu Ser Leu Val Gly Ser Asp Pro 
                645                 650 


<210>  84
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val 
                325                 330                 335     


Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr 
            340                 345                 350         


Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val 
        355                 360                 365             


Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe 
    370                 375                 380                 


Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu 
385                 390                 395                 400 


Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr 
                405                 410                 415     


Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr 
            420                 425                 430         


Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln 
        435                 440                 445             


Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu 
    450                 455                 460                 


Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu 
465                 470                 475                 480 


Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp 
                485                 490                 495     


Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu 
            500                 505                 510         


Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr 
        515                 520                 525             


Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile 
    530                 535                 540                 


Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser 
545                 550                 555                 560 


Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His 
                565                 570                 575     


Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr 
            580                 585                 590         


Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp 
        595                 600                 605             


Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu 
    610                 615                 620                 


Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu 
625                 630                 635                 640 


Leu Ser Leu Val Gly Ser Asp Pro 
                645             


<210>  85
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
                325                 330                 335     


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            340                 345                 350         


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        355                 360                 365             


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    370                 375                 380                 


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
385                 390                 395                 400 


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                405                 410                 415     


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            420                 425                 430         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        435                 440                 445             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    450                 455                 460                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
465                 470                 475                 480 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                485                 490                 495     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            500                 505                 510         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        515                 520                 525             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    530                 535                 540                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
545                 550                 555                 560 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                565                 570                 575     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            580                 585                 590         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        595                 600                 605             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    610                 615                 620                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
625                 630                 635                 640 


Ser Leu Val Gly Ser Asp Pro 
                645         


<210>  86
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val 
        675                 680                 685             


Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr 
    690                 695                 700                 


Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val 
705                 710                 715                 720 


Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe 
                725                 730                 735     


Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu 
            740                 745                 750         


Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr 
        755                 760                 765             


Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr 
    770                 775                 780                 


Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln 
785                 790                 795                 800 


Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu 
                805                 810                 815     


Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu 
            820                 825                 830         


Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp 
        835                 840                 845             


Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu 
    850                 855                 860                 


Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr 
865                 870                 875                 880 


Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile 
                885                 890                 895     


Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser 
            900                 905                 910         


Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His 
        915                 920                 925             


Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr 
    930                 935                 940                 


Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp 
945                 950                 955                 960 


Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu 
                965                 970                 975     


Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu 
            980                 985                 990         


Leu Ser Leu Val Gly Ser Asp Pro  
        995                 1000 


<210>  87
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr 
465                 470                 475                 480 


Val Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu 
                485                 490                 495     


Tyr Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp 
            500                 505                 510         


Val Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser 
        515                 520                 525             


Phe Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu 
    530                 535                 540                 


Leu Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro 
545                 550                 555                 560 


Tyr Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly 
                565                 570                 575     


Thr Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn 
            580                 585                 590         


Gln Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser 
        595                 600                 605             


Leu Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile 
    610                 615                 620                 


Leu Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val 
625                 630                 635                 640 


Asp Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly 
                645                 650                 655     


Glu Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys 
            660                 665                 670         


Thr Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys 
        675                 680                 685             


Ile Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly 
    690                 695                 700                 


Ser Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu 
705                 710                 715                 720 


His Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly 
                725                 730                 735     


Thr Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile 
            740                 745                 750         


Asp Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr 
        755                 760                 765             


Leu Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala 
    770                 775                 780                 


Leu Leu Ser Leu Val Gly Ser Asp Pro 
785                 790             


<210>  88
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ala Trp Trp Lys Ala Trp Ile Glu 
                325                 330                 335     


Gln Glu Gly Val Thr Val Lys Ser Ser Ser His Phe Asn Pro Asp Pro 
            340                 345                 350         


Asp Ala Glu Thr Leu Tyr Lys Ala Met Lys Gly Ile Gly Thr Asn Glu 
        355                 360                 365             


Gln Ala Ile Ile Asp Val Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln 
    370                 375                 380                 


Gln Ile Ala Lys Ser Phe Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu 
385                 390                 395                 400 


Thr Leu Lys Ser Glu Leu Ser Gly Lys Phe Glu Arg Leu Ile Val Ala 
                405                 410                 415     


Leu Met Tyr Pro Pro Tyr Arg Tyr Glu Ala Lys Glu Leu His Asp Ala 
            420                 425                 430         


Met Lys Gly Leu Gly Thr Lys Glu Gly Val Ile Ile Glu Ile Leu Ala 
        435                 440                 445             


Ser Arg Thr Lys Asn Gln Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu 
    450                 455                 460                 


Asp Tyr Gly Ser Ser Leu Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly 
465                 470                 475                 480 


Tyr Leu Glu Arg Ile Leu Val Cys Leu Leu Gln Gly Ser Arg Asp Asp 
                485                 490                 495     


Val Ser Ser Phe Val Asp Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp 
            500                 505                 510         


Leu Tyr Ala Ala Gly Glu Lys Ile Arg Gly Thr Asp Glu Met Lys Phe 
        515                 520                 525             


Ile Thr Ile Leu Cys Thr Arg Ser Ala Thr His Leu Leu Arg Val Phe 
    530                 535                 540                 


Glu Glu Tyr Glu Lys Ile Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys 
545                 550                 555                 560 


Ser Glu Thr His Gly Ser Leu Glu Glu Ala Met Leu Thr Val Val Lys 
                565                 570                 575     


Cys Thr Gln Asn Leu His Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala 
            580                 585                 590         


Met Lys Gly Ala Gly Thr Arg Asp Gly Thr Leu Ile Arg Asn Ile Val 
        595                 600                 605             


Ser Arg Ser Glu Ile Asp Leu Asn Leu Ile Lys Cys His Phe Lys Lys 
    610                 615                 620                 


Met Tyr Gly Lys Thr Leu Ser Ser Met Ile Met Glu Asp Thr Ser Gly 
625                 630                 635                 640 


Asp Tyr Lys Asn Ala Leu Leu Ser Leu Val Gly Ser Asp Pro 
                645                 650                 


<210>  89
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ala Trp Trp Lys Ala Trp 
            500                 505                 510         


Ile Glu Gln Glu Gly Val Thr Val Lys Ser Ser Ser His Phe Asn Pro 
        515                 520                 525             


Asp Pro Asp Ala Glu Thr Leu Tyr Lys Ala Met Lys Gly Ile Gly Thr 
    530                 535                 540                 


Asn Glu Gln Ala Ile Ile Asp Val Leu Thr Lys Arg Ser Asn Thr Gln 
545                 550                 555                 560 


Arg Gln Gln Ile Ala Lys Ser Phe Lys Ala Gln Phe Gly Lys Asp Leu 
                565                 570                 575     


Thr Glu Thr Leu Lys Ser Glu Leu Ser Gly Lys Phe Glu Arg Leu Ile 
            580                 585                 590         


Val Ala Leu Met Tyr Pro Pro Tyr Arg Tyr Glu Ala Lys Glu Leu His 
        595                 600                 605             


Asp Ala Met Lys Gly Leu Gly Thr Lys Glu Gly Val Ile Ile Glu Ile 
    610                 615                 620                 


Leu Ala Ser Arg Thr Lys Asn Gln Leu Arg Glu Ile Met Lys Ala Tyr 
625                 630                 635                 640 


Glu Glu Asp Tyr Gly Ser Ser Leu Glu Glu Asp Ile Gln Ala Asp Thr 
                645                 650                 655     


Ser Gly Tyr Leu Glu Arg Ile Leu Val Cys Leu Leu Gln Gly Ser Arg 
            660                 665                 670         


Asp Asp Val Ser Ser Phe Val Asp Pro Ala Leu Ala Leu Gln Asp Ala 
        675                 680                 685             


Gln Asp Leu Tyr Ala Ala Gly Glu Lys Ile Arg Gly Thr Asp Glu Met 
    690                 695                 700                 


Lys Phe Ile Thr Ile Leu Cys Thr Arg Ser Ala Thr His Leu Leu Arg 
705                 710                 715                 720 


Val Phe Glu Glu Tyr Glu Lys Ile Ala Asn Lys Ser Ile Glu Asp Ser 
                725                 730                 735     


Ile Lys Ser Glu Thr His Gly Ser Leu Glu Glu Ala Met Leu Thr Val 
            740                 745                 750         


Val Lys Cys Thr Gln Asn Leu His Ser Tyr Phe Ala Glu Arg Leu Tyr 
        755                 760                 765             


Tyr Ala Met Lys Gly Ala Gly Thr Arg Asp Gly Thr Leu Ile Arg Asn 
    770                 775                 780                 


Ile Val Ser Arg Ser Glu Ile Asp Leu Asn Leu Ile Lys Cys His Phe 
785                 790                 795                 800 


Lys Lys Met Tyr Gly Lys Thr Leu Ser Ser Met Ile Met Glu Asp Thr 
                805                 810                 815     


Ser Gly Asp Tyr Lys Asn Ala Leu Leu Ser Leu Val Gly Ser Asp Pro 
            820                 825                 830         


<210>  90
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ala Trp Trp 
305                 310                 315                 320 


Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys Ser Ser Ser His 
                325                 330                 335     


Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys Ala Met Lys Gly 
            340                 345                 350         


Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu Thr Lys Arg Ser 
        355                 360                 365             


Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys Ala Gln Phe Gly 
    370                 375                 380                 


Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser Gly Lys Phe Glu 
385                 390                 395                 400 


Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg Tyr Glu Ala Lys 
                405                 410                 415     


Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys Glu Gly Val Ile 
            420                 425                 430         


Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu Arg Glu Ile Met 
        435                 440                 445             


Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu Glu Asp Ile Gln 
    450                 455                 460                 


Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val Cys Leu Leu Gln 
465                 470                 475                 480 


Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro Ala Leu Ala Leu 
                485                 490                 495     


Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys Ile Arg Gly Thr 
            500                 505                 510         


Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg Ser Ala Thr His 
        515                 520                 525             


Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala Asn Lys Ser Ile 
    530                 535                 540                 


Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu Glu Glu Ala Met 
545                 550                 555                 560 


Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser Tyr Phe Ala Glu 
                565                 570                 575     


Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg Asp Gly Thr Leu 
            580                 585                 590         


Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu Asn Leu Ile Lys 
        595                 600                 605             


Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser Ser Met Ile Met 
    610                 615                 620                 


Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu Ser Leu Val Gly 
625                 630                 635                 640 


Ser Asp Pro 
            


<210>  91
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Ser Tyr Pro Gly Tyr 
            340                 345                 350         


Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala Ala Pro Gly Gly Gly Pro 
        355                 360                 365             


Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro Ser Met Pro Pro Ile Gly 
    370                 375                 380                 


Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln Phe Asn Gln Asp Tyr Leu 
385                 390                 395                 400 


Ser Gly Met Ala Ala Asn Met Ser Gly Thr Phe Gly Gly Ala Asn Met 
                405                 410                 415     


Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala Gly Tyr Pro Pro Val Pro 
            420                 425                 430         


Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala Gln Gln Pro Val Pro Pro 
        435                 440                 445             


Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn Pro Pro Ser Arg Met Pro 
    450                 455                 460                 


Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val Pro Gly Gln Pro Met Pro 
465                 470                 475                 480 


Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr Pro Gly Gln Pro Pro Val 
                485                 490                 495     


Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu Pro Gly Gln Gln Gln Pro 
            500                 505                 510         


Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser Gly Thr Val Thr Pro Ala 
        515                 520                 525             


Val Pro Pro Thr Gln Phe Gly Ser Arg Gly Thr Ile Thr Asp Ala Pro 
    530                 535                 540                 


Gly Phe Asp Pro Leu Arg Asp Ala Glu Val Leu Arg Lys Ala Met Lys 
545                 550                 555                 560 


Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile Asp Cys Leu Gly Ser Arg 
                565                 570                 575     


Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu Ser Phe Lys Thr Ala Tyr 
            580                 585                 590         


Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe 
        595                 600                 605             


Glu Lys Thr Ile Leu Ala Leu Met Lys Thr Pro Val Leu Phe Asp Ile 
    610                 615                 620                 


Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val Gly Thr Asp Glu Ala Cys 
625                 630                 635                 640 


Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn Glu His Ile Arg Glu Leu 
                645                 650                 655     


Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys Thr Leu Glu Glu Ala Ile 
            660                 665                 670         


Arg Ser Asp Thr Ser Gly His Phe Gln Arg Leu Leu Ile Ser Leu Ser 
        675                 680                 685             


Gln Gly Asn Arg Asp Glu Ser Thr Asn Val Asp Met Ser Leu Ala Gln 
    690                 695                 700                 


Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly Glu Asn Arg Leu Gly Thr 
705                 710                 715                 720 


Asp Glu Ser Lys Phe Asn Ala Val Leu Cys Ser Arg Ser Arg Ala His 
                725                 730                 735     


Leu Val Ala Val Phe Asn Glu Tyr Gln Arg Met Thr Gly Arg Asp Ile 
            740                 745                 750         


Glu Lys Ser Ile Cys Arg Glu Met Ser Gly Asp Leu Glu Glu Gly Met 
        755                 760                 765             


Leu Ala Val Val Lys Cys Leu Lys Asn Thr Pro Ala Phe Phe Ala Glu 
    770                 775                 780                 


Arg Leu Asn Lys Ala Met Arg Gly Ala Gly Thr Lys Asp Arg Thr Leu 
785                 790                 795                 800 


Ile Arg Ile Met Val Ser Arg Ser Glu Thr Asp Leu Leu Asp Ile Arg 
                805                 810                 815     


Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser Leu Tyr His Asp Ile Ser 
            820                 825                 830         


Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile Leu Leu Lys Ile Cys Gly 
        835                 840                 845             


Gly Asn Asp 
    850     


<210>  92
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr 
            340                 345                 350         


Pro Pro Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro 
        355                 360                 365             


Pro Pro Pro Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr 
    370                 375                 380                 


Ala Gly Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met 
385                 390                 395                 400 


Ser Gly Thr Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala 
                405                 410                 415     


Pro Gly Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro 
            420                 425                 430         


Pro Ser Ala Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro 
        435                 440                 445             


Gly Gly Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly 
    450                 455                 460                 


Ala Pro Val Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro 
465                 470                 475                 480 


Gly Ala Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro 
                485                 490                 495     


Val Pro Leu Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr 
            500                 505                 510         


Pro Gly Ser Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly 
        515                 520                 525             


Ser Arg Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp 
    530                 535                 540                 


Ala Glu Val Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln 
545                 550                 555                 560 


Ala Ile Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln 
                565                 570                 575     


Ile Leu Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp 
            580                 585                 590         


Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu 
        595                 600                 605             


Met Lys Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile 
    610                 615                 620                 


Lys Gly Val Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser 
625                 630                 635                 640 


Arg Ser Asn Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu 
                645                 650                 655     


Phe Lys Lys Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His 
            660                 665                 670         


Phe Gln Arg Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser 
        675                 680                 685             


Thr Asn Val Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr 
    690                 695                 700                 


Ala Ala Gly Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala 
705                 710                 715                 720 


Val Leu Cys Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu 
                725                 730                 735     


Tyr Gln Arg Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu 
            740                 745                 750         


Met Ser Gly Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu 
        755                 760                 765             


Lys Asn Thr Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg 
    770                 775                 780                 


Gly Ala Gly Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg 
785                 790                 795                 800 


Ser Glu Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr 
                805                 810                 815     


Gly Lys Ser Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr 
            820                 825                 830         


Arg Lys Ile Leu Leu Lys Ile Cys Gly Gly Asn Asp 
        835                 840                 


<210>  93
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr 
                325                 330                 335     


Pro Pro Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro 
            340                 345                 350         


Pro Pro Pro Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr 
        355                 360                 365             


Ala Gly Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met 
    370                 375                 380                 


Ser Gly Thr Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala 
385                 390                 395                 400 


Pro Gly Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro 
                405                 410                 415     


Pro Ser Ala Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro 
            420                 425                 430         


Gly Gly Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly 
        435                 440                 445             


Ala Pro Val Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro 
    450                 455                 460                 


Gly Ala Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro 
465                 470                 475                 480 


Val Pro Leu Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr 
                485                 490                 495     


Pro Gly Ser Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly 
            500                 505                 510         


Ser Arg Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp 
        515                 520                 525             


Ala Glu Val Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln 
    530                 535                 540                 


Ala Ile Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln 
545                 550                 555                 560 


Ile Leu Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp 
                565                 570                 575     


Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu 
            580                 585                 590         


Met Lys Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile 
        595                 600                 605             


Lys Gly Val Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser 
    610                 615                 620                 


Arg Ser Asn Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu 
625                 630                 635                 640 


Phe Lys Lys Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His 
                645                 650                 655     


Phe Gln Arg Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser 
            660                 665                 670         


Thr Asn Val Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr 
        675                 680                 685             


Ala Ala Gly Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala 
    690                 695                 700                 


Val Leu Cys Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu 
705                 710                 715                 720 


Tyr Gln Arg Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu 
                725                 730                 735     


Met Ser Gly Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu 
            740                 745                 750         


Lys Asn Thr Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg 
        755                 760                 765             


Gly Ala Gly Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg 
    770                 775                 780                 


Ser Glu Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr 
785                 790                 795                 800 


Gly Lys Ser Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr 
                805                 810                 815     


Arg Lys Ile Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            820                 825             


<210>  94
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro 
                325                 330                 335     


Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro 
            340                 345                 350         


Pro Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly 
        355                 360                 365             


Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly 
    370                 375                 380                 


Thr Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly 
385                 390                 395                 400 


Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser 
                405                 410                 415     


Ala Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly 
            420                 425                 430         


Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro 
        435                 440                 445             


Val Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala 
    450                 455                 460                 


Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro 
465                 470                 475                 480 


Leu Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly 
                485                 490                 495     


Ser Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg 
            500                 505                 510         


Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu 
        515                 520                 525             


Val Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
    530                 535                 540                 


Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu 
545                 550                 555                 560 


Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
                565                 570                 575     


Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys 
            580                 585                 590         


Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly 
        595                 600                 605             


Val Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser 
    610                 615                 620                 


Asn Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys 
625                 630                 635                 640 


Lys Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln 
                645                 650                 655     


Arg Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn 
            660                 665                 670         


Val Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala 
        675                 680                 685             


Gly Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu 
    690                 695                 700                 


Cys Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln 
705                 710                 715                 720 


Arg Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser 
                725                 730                 735     


Gly Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn 
            740                 745                 750         


Thr Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala 
        755                 760                 765             


Gly Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu 
    770                 775                 780                 


Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys 
785                 790                 795                 800 


Ser Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys 
                805                 810                 815     


Ile Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            820                 825     


<210>  95
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
                325                 330                 335     


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            340                 345                 350         


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        355                 360                 365             


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    370                 375                 380                 


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
385                 390                 395                 400 


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                405                 410                 415     


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            420                 425                 430         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        435                 440                 445             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    450                 455                 460                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
465                 470                 475                 480 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                485                 490                 495     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            500                 505                 510         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        515                 520                 525             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    530                 535                 540                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
545                 550                 555                 560 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                565                 570                 575     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            580                 585                 590         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        595                 600                 605             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    610                 615                 620                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
625                 630                 635                 640 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                645                 650                 655     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            660                 665                 670         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        675                 680                 685             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    690                 695                 700                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
705                 710                 715                 720 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                725                 730                 735     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            740                 745                 750         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        755                 760                 765             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    770                 775                 780                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
785                 790                 795                 800 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                805                 810                 815     


Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            820                 825 


<210>  96
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro 
        675                 680                 685             


Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro 
    690                 695                 700                 


Pro Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly 
705                 710                 715                 720 


Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly 
                725                 730                 735     


Thr Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly 
            740                 745                 750         


Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser 
        755                 760                 765             


Ala Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly 
    770                 775                 780                 


Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro 
785                 790                 795                 800 


Val Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala 
                805                 810                 815     


Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro 
            820                 825                 830         


Leu Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly 
        835                 840                 845             


Ser Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg 
    850                 855                 860                 


Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu 
865                 870                 875                 880 


Val Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
                885                 890                 895     


Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu 
            900                 905                 910         


Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
        915                 920                 925             


Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys 
    930                 935                 940                 


Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly 
945                 950                 955                 960 


Val Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser 
                965                 970                 975     


Asn Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys 
            980                 985                 990         


Lys Thr Leu Glu Glu Ala Ile Arg  Ser Asp Thr Ser Gly  His Phe Gln 
        995                 1000                 1005             


Arg Leu  Leu Ile Ser Leu Ser  Gln Gly Asn Arg Asp  Glu Ser Thr 
    1010                 1015                 1020             


Asn Val  Asp Met Ser Leu Ala  Gln Arg Asp Ala Gln  Glu Leu Tyr 
    1025                 1030                 1035             


Ala Ala  Gly Glu Asn Arg Leu  Gly Thr Asp Glu Ser  Lys Phe Asn 
    1040                 1045                 1050             


Ala Val  Leu Cys Ser Arg Ser  Arg Ala His Leu Val  Ala Val Phe 
    1055                 1060                 1065             


Asn Glu  Tyr Gln Arg Met Thr  Gly Arg Asp Ile Glu  Lys Ser Ile 
    1070                 1075                 1080             


Cys Arg  Glu Met Ser Gly Asp  Leu Glu Glu Gly Met  Leu Ala Val 
    1085                 1090                 1095             


Val Lys  Cys Leu Lys Asn Thr  Pro Ala Phe Phe Ala  Glu Arg Leu 
    1100                 1105                 1110             


Asn Lys  Ala Met Arg Gly Ala  Gly Thr Lys Asp Arg  Thr Leu Ile 
    1115                 1120                 1125             


Arg Ile  Met Val Ser Arg Ser  Glu Thr Asp Leu Leu  Asp Ile Arg 
    1130                 1135                 1140             


Ser Glu  Tyr Lys Arg Met Tyr  Gly Lys Ser Leu Tyr  His Asp Ile 
    1145                 1150                 1155             


Ser Gly  Asp Thr Ser Gly Asp  Tyr Arg Lys Ile Leu  Leu Lys Ile 
    1160                 1165                 1170             


Cys Gly  Gly Asn Asp 
    1175             


<210>  97
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro 
465                 470                 475                 480 


Pro Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro 
                485                 490                 495     


Pro Pro Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala 
            500                 505                 510         


Gly Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser 
        515                 520                 525             


Gly Thr Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro 
    530                 535                 540                 


Gly Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro 
545                 550                 555                 560 


Ser Ala Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly 
                565                 570                 575     


Gly Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala 
            580                 585                 590         


Pro Val Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly 
        595                 600                 605             


Ala Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val 
    610                 615                 620                 


Pro Leu Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro 
625                 630                 635                 640 


Gly Ser Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser 
                645                 650                 655     


Arg Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala 
            660                 665                 670         


Glu Val Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala 
        675                 680                 685             


Ile Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile 
    690                 695                 700                 


Leu Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu 
705                 710                 715                 720 


Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met 
                725                 730                 735     


Lys Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys 
            740                 745                 750         


Gly Val Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg 
        755                 760                 765             


Ser Asn Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe 
    770                 775                 780                 


Lys Lys Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe 
785                 790                 795                 800 


Gln Arg Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr 
                805                 810                 815     


Asn Val Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala 
            820                 825                 830         


Ala Gly Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val 
        835                 840                 845             


Leu Cys Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr 
    850                 855                 860                 


Gln Arg Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met 
865                 870                 875                 880 


Ser Gly Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys 
                885                 890                 895     


Asn Thr Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly 
            900                 905                 910         


Ala Gly Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser 
        915                 920                 925             


Glu Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly 
    930                 935                 940                 


Lys Ser Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg 
945                 950                 955                 960 


Lys Ile Leu Leu Lys Ile Cys Gly Gly Asn Asp 
                965                 970     


<210>  98
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Ser Tyr Pro Gly Tyr Pro Pro Pro 
                325                 330                 335     


Pro Gly Gly Tyr Pro Pro Ala Ala Pro Gly Gly Gly Pro Trp Gly Gly 
            340                 345                 350         


Ala Ala Tyr Pro Pro Pro Pro Ser Met Pro Pro Ile Gly Leu Asp Asn 
        355                 360                 365             


Val Ala Thr Tyr Ala Gly Gln Phe Asn Gln Asp Tyr Leu Ser Gly Met 
    370                 375                 380                 


Ala Ala Asn Met Ser Gly Thr Phe Gly Gly Ala Asn Met Pro Asn Leu 
385                 390                 395                 400 


Tyr Pro Gly Ala Pro Gly Ala Gly Tyr Pro Pro Val Pro Pro Gly Gly 
                405                 410                 415     


Phe Gly Gln Pro Pro Ser Ala Gln Gln Pro Val Pro Pro Tyr Gly Met 
            420                 425                 430         


Tyr Pro Pro Pro Gly Gly Asn Pro Pro Ser Arg Met Pro Ser Tyr Pro 
        435                 440                 445             


Pro Tyr Pro Gly Ala Pro Val Pro Gly Gln Pro Met Pro Pro Pro Gly 
    450                 455                 460                 


Gln Gln Pro Pro Gly Ala Tyr Pro Gly Gln Pro Pro Val Thr Tyr Pro 
465                 470                 475                 480 


Gly Gln Pro Pro Val Pro Leu Pro Gly Gln Gln Gln Pro Val Pro Ser 
                485                 490                 495     


Tyr Pro Gly Tyr Pro Gly Ser Gly Thr Val Thr Pro Ala Val Pro Pro 
            500                 505                 510         


Thr Gln Phe Gly Ser Arg Gly Thr Ile Thr Asp Ala Pro Gly Phe Asp 
        515                 520                 525             


Pro Leu Arg Asp Ala Glu Val Leu Arg Lys Ala Met Lys Gly Phe Gly 
    530                 535                 540                 


Thr Asp Glu Gln Ala Ile Ile Asp Cys Leu Gly Ser Arg Ser Asn Lys 
545                 550                 555                 560 


Gln Arg Gln Gln Ile Leu Leu Ser Phe Lys Thr Ala Tyr Gly Lys Asp 
                565                 570                 575     


Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr 
            580                 585                 590         


Ile Leu Ala Leu Met Lys Thr Pro Val Leu Phe Asp Ile Tyr Glu Ile 
        595                 600                 605             


Lys Glu Ala Ile Lys Gly Val Gly Thr Asp Glu Ala Cys Leu Ile Glu 
    610                 615                 620                 


Ile Leu Ala Ser Arg Ser Asn Glu His Ile Arg Glu Leu Asn Arg Ala 
625                 630                 635                 640 


Tyr Lys Ala Glu Phe Lys Lys Thr Leu Glu Glu Ala Ile Arg Ser Asp 
                645                 650                 655     


Thr Ser Gly His Phe Gln Arg Leu Leu Ile Ser Leu Ser Gln Gly Asn 
            660                 665                 670         


Arg Asp Glu Ser Thr Asn Val Asp Met Ser Leu Ala Gln Arg Asp Ala 
        675                 680                 685             


Gln Glu Leu Tyr Ala Ala Gly Glu Asn Arg Leu Gly Thr Asp Glu Ser 
    690                 695                 700                 


Lys Phe Asn Ala Val Leu Cys Ser Arg Ser Arg Ala His Leu Val Ala 
705                 710                 715                 720 


Val Phe Asn Glu Tyr Gln Arg Met Thr Gly Arg Asp Ile Glu Lys Ser 
                725                 730                 735     


Ile Cys Arg Glu Met Ser Gly Asp Leu Glu Glu Gly Met Leu Ala Val 
            740                 745                 750         


Val Lys Cys Leu Lys Asn Thr Pro Ala Phe Phe Ala Glu Arg Leu Asn 
        755                 760                 765             


Lys Ala Met Arg Gly Ala Gly Thr Lys Asp Arg Thr Leu Ile Arg Ile 
    770                 775                 780                 


Met Val Ser Arg Ser Glu Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr 
785                 790                 795                 800 


Lys Arg Met Tyr Gly Lys Ser Leu Tyr His Asp Ile Ser Gly Asp Thr 
                805                 810                 815     


Ser Gly Asp Tyr Arg Lys Ile Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            820                 825                 830         


<210>  99
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Ser Tyr Pro Gly Tyr Pro 
            500                 505                 510         


Pro Pro Pro Gly Gly Tyr Pro Pro Ala Ala Pro Gly Gly Gly Pro Trp 
        515                 520                 525             


Gly Gly Ala Ala Tyr Pro Pro Pro Pro Ser Met Pro Pro Ile Gly Leu 
    530                 535                 540                 


Asp Asn Val Ala Thr Tyr Ala Gly Gln Phe Asn Gln Asp Tyr Leu Ser 
545                 550                 555                 560 


Gly Met Ala Ala Asn Met Ser Gly Thr Phe Gly Gly Ala Asn Met Pro 
                565                 570                 575     


Asn Leu Tyr Pro Gly Ala Pro Gly Ala Gly Tyr Pro Pro Val Pro Pro 
            580                 585                 590         


Gly Gly Phe Gly Gln Pro Pro Ser Ala Gln Gln Pro Val Pro Pro Tyr 
        595                 600                 605             


Gly Met Tyr Pro Pro Pro Gly Gly Asn Pro Pro Ser Arg Met Pro Ser 
    610                 615                 620                 


Tyr Pro Pro Tyr Pro Gly Ala Pro Val Pro Gly Gln Pro Met Pro Pro 
625                 630                 635                 640 


Pro Gly Gln Gln Pro Pro Gly Ala Tyr Pro Gly Gln Pro Pro Val Thr 
                645                 650                 655     


Tyr Pro Gly Gln Pro Pro Val Pro Leu Pro Gly Gln Gln Gln Pro Val 
            660                 665                 670         


Pro Ser Tyr Pro Gly Tyr Pro Gly Ser Gly Thr Val Thr Pro Ala Val 
        675                 680                 685             


Pro Pro Thr Gln Phe Gly Ser Arg Gly Thr Ile Thr Asp Ala Pro Gly 
    690                 695                 700                 


Phe Asp Pro Leu Arg Asp Ala Glu Val Leu Arg Lys Ala Met Lys Gly 
705                 710                 715                 720 


Phe Gly Thr Asp Glu Gln Ala Ile Ile Asp Cys Leu Gly Ser Arg Ser 
                725                 730                 735     


Asn Lys Gln Arg Gln Gln Ile Leu Leu Ser Phe Lys Thr Ala Tyr Gly 
            740                 745                 750         


Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
        755                 760                 765             


Lys Thr Ile Leu Ala Leu Met Lys Thr Pro Val Leu Phe Asp Ile Tyr 
    770                 775                 780                 


Glu Ile Lys Glu Ala Ile Lys Gly Val Gly Thr Asp Glu Ala Cys Leu 
785                 790                 795                 800 


Ile Glu Ile Leu Ala Ser Arg Ser Asn Glu His Ile Arg Glu Leu Asn 
                805                 810                 815     


Arg Ala Tyr Lys Ala Glu Phe Lys Lys Thr Leu Glu Glu Ala Ile Arg 
            820                 825                 830         


Ser Asp Thr Ser Gly His Phe Gln Arg Leu Leu Ile Ser Leu Ser Gln 
        835                 840                 845             


Gly Asn Arg Asp Glu Ser Thr Asn Val Asp Met Ser Leu Ala Gln Arg 
    850                 855                 860                 


Asp Ala Gln Glu Leu Tyr Ala Ala Gly Glu Asn Arg Leu Gly Thr Asp 
865                 870                 875                 880 


Glu Ser Lys Phe Asn Ala Val Leu Cys Ser Arg Ser Arg Ala His Leu 
                885                 890                 895     


Val Ala Val Phe Asn Glu Tyr Gln Arg Met Thr Gly Arg Asp Ile Glu 
            900                 905                 910         


Lys Ser Ile Cys Arg Glu Met Ser Gly Asp Leu Glu Glu Gly Met Leu 
        915                 920                 925             


Ala Val Val Lys Cys Leu Lys Asn Thr Pro Ala Phe Phe Ala Glu Arg 
    930                 935                 940                 


Leu Asn Lys Ala Met Arg Gly Ala Gly Thr Lys Asp Arg Thr Leu Ile 
945                 950                 955                 960 


Arg Ile Met Val Ser Arg Ser Glu Thr Asp Leu Leu Asp Ile Arg Ser 
                965                 970                 975     


Glu Tyr Lys Arg Met Tyr Gly Lys Ser Leu Tyr His Asp Ile Ser Gly 
            980                 985                 990         


Asp Thr Ser Gly Asp Tyr Arg Lys  Ile Leu Leu Lys Ile  Cys Gly Gly 
        995                 1000                 1005             


Asn Asp  
    1010 


<210>  100
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Ser Tyr Pro 
305                 310                 315                 320 


Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala Ala Pro Gly Gly 
                325                 330                 335     


Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro Ser Met Pro Pro 
            340                 345                 350         


Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln Phe Asn Gln Asp 
        355                 360                 365             


Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr Phe Gly Gly Ala 
    370                 375                 380                 


Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala Gly Tyr Pro Pro 
385                 390                 395                 400 


Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala Gln Gln Pro Val 
                405                 410                 415     


Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn Pro Pro Ser Arg 
            420                 425                 430         


Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val Pro Gly Gln Pro 
        435                 440                 445             


Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr Pro Gly Gln Pro 
    450                 455                 460                 


Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu Pro Gly Gln Gln 
465                 470                 475                 480 


Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser Gly Thr Val Thr 
                485                 490                 495     


Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly Thr Ile Thr Asp 
            500                 505                 510         


Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val Leu Arg Lys Ala 
        515                 520                 525             


Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile Asp Cys Leu Gly 
    530                 535                 540                 


Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu Ser Phe Lys Thr 
545                 550                 555                 560 


Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly 
                565                 570                 575     


Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr Pro Val Leu Phe 
            580                 585                 590         


Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val Gly Thr Asp Glu 
        595                 600                 605             


Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn Glu His Ile Arg 
    610                 615                 620                 


Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys Thr Leu Glu Glu 
625                 630                 635                 640 


Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg Leu Leu Ile Ser 
                645                 650                 655     


Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val Asp Met Ser Leu 
            660                 665                 670         


Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly Glu Asn Arg Leu 
        675                 680                 685             


Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys Ser Arg Ser Arg 
    690                 695                 700                 


Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg Met Thr Gly Arg 
705                 710                 715                 720 


Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly Asp Leu Glu Glu 
                725                 730                 735     


Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr Pro Ala Phe Phe 
            740                 745                 750         


Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly Thr Lys Asp Arg 
        755                 760                 765             


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr Asp Leu Leu Asp 
    770                 775                 780                 


Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser Leu Tyr His Asp 
785                 790                 795                 800 


Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile Leu Leu Lys Ile 
                805                 810                 815     


Cys Gly Gly Asn Asp 
            820     


<210>  101
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn Met Gly Asn Arg His Ala 
            340                 345                 350         


Lys Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys Lys 
        355                 360                 365             


Leu Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile Ile 
    370                 375                 380                 


Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys Gln 
385                 390                 395                 400 


Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys Ser 
                405                 410                 415     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp Arg 
            420                 425                 430         


Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly Leu 
        435                 440                 445             


Gly Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr Asn 
    450                 455                 460                 


Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp Arg 
465                 470                 475                 480 


Ser Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys Lys 
                485                 490                 495     


Ile Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp Val 
            500                 505                 510         


Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala Gly 
        515                 520                 525             


Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu Ala 
    530                 535                 540                 


Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln Ile 
545                 550                 555                 560 


Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser Gly 
                565                 570                 575     


Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp Cys 
            580                 585                 590         


Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala Gly 
        595                 600                 605             


Thr Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu Val 
    610                 615                 620                 


Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu 
                645                 650                 655     


Leu Val Ala Leu Leu His 
            660         


<210>  102
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly 
            340                 345                 350         


Phe Asp Val Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly 
        355                 360                 365             


Met Gly Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr 
    370                 375                 380                 


Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly 
385                 390                 395                 400 


Lys Glu Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
                405                 410                 415     


Lys Thr Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg 
            420                 425                 430         


Gln Leu Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu 
        435                 440                 445             


Ile Glu Val Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys 
    450                 455                 460                 


Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys 
465                 470                 475                 480 


Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln 
                485                 490                 495     


Ala Asn Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln 
            500                 505                 510         


Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp 
        515                 520                 525             


Glu Leu Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu 
    530                 535                 540                 


Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu 
545                 550                 555                 560 


Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu 
                565                 570                 575     


Thr Leu Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg 
            580                 585                 590         


Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile 
        595                 600                 605             


Arg Ile Val Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala 
    610                 615                 620                 


Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser 
625                 630                 635                 640 


Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
                645                 650                 655 


<210>  103
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly 
                325                 330                 335     


Phe Asp Val Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly 
            340                 345                 350         


Met Gly Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr 
        355                 360                 365             


Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly 
    370                 375                 380                 


Lys Glu Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu 
385                 390                 395                 400 


Lys Thr Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg 
                405                 410                 415     


Gln Leu Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu 
            420                 425                 430         


Ile Glu Val Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys 
        435                 440                 445             


Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys 
    450                 455                 460                 


Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln 
465                 470                 475                 480 


Ala Asn Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln 
                485                 490                 495     


Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp 
            500                 505                 510         


Glu Leu Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu 
        515                 520                 525             


Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu 
    530                 535                 540                 


Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu 
545                 550                 555                 560 


Thr Leu Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg 
                565                 570                 575     


Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile 
            580                 585                 590         


Arg Ile Val Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala 
        595                 600                 605             


Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser 
    610                 615                 620                 


Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
625                 630                 635                 


<210>  104
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp 
                325                 330                 335     


Val Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly 
            340                 345                 350         


Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp 
        355                 360                 365             


Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu 
    370                 375                 380                 


Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr 
385                 390                 395                 400 


Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu 
                405                 410                 415     


Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu 
            420                 425                 430         


Val Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala 
        435                 440                 445             


Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp 
    450                 455                 460                 


Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn 
465                 470                 475                 480 


Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala 
                485                 490                 495     


Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu 
            500                 505                 510         


Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala 
        515                 520                 525             


Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala 
    530                 535                 540                 


Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu 
545                 550                 555                 560 


Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr 
                565                 570                 575     


Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile 
            580                 585                 590         


Val Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe 
        595                 600                 605             


Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr 
    610                 615                 620                 


Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
625                 630                 635         


<210>  105
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
                325                 330                 335     


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            340                 345                 350         


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        355                 360                 365             


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    370                 375                 380                 


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
385                 390                 395                 400 


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                405                 410                 415     


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            420                 425                 430         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        435                 440                 445             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    450                 455                 460                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
465                 470                 475                 480 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                485                 490                 495     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            500                 505                 510         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        515                 520                 525             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    530                 535                 540                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
545                 550                 555                 560 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                565                 570                 575     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            580                 585                 590         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        595                 600                 605             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    610                 615                 620                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
625                 630                 635     


<210>  106
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp 
        675                 680                 685             


Val Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly 
    690                 695                 700                 


Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp 
705                 710                 715                 720 


Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu 
                725                 730                 735     


Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr 
            740                 745                 750         


Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu 
        755                 760                 765             


Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu 
    770                 775                 780                 


Val Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala 
785                 790                 795                 800 


Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp 
                805                 810                 815     


Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn 
            820                 825                 830         


Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala 
        835                 840                 845             


Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu 
    850                 855                 860                 


Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala 
865                 870                 875                 880 


Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala 
                885                 890                 895     


Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu 
            900                 905                 910         


Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr 
        915                 920                 925             


Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile 
    930                 935                 940                 


Val Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe 
945                 950                 955                 960 


Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr 
                965                 970                 975     


Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
            980                 985                 


<210>  107
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe 
465                 470                 475                 480 


Asp Val Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met 
                485                 490                 495     


Gly Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser 
            500                 505                 510         


Asp Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys 
        515                 520                 525             


Glu Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys 
    530                 535                 540                 


Thr Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln 
545                 550                 555                 560 


Leu Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile 
                565                 570                 575     


Glu Val Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu 
            580                 585                 590         


Ala Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly 
        595                 600                 605             


Asp Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala 
    610                 615                 620                 


Asn Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp 
625                 630                 635                 640 


Ala Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu 
                645                 650                 655     


Leu Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg 
            660                 665                 670         


Ala Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu 
        675                 680                 685             


Ala Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr 
    690                 695                 700                 


Leu Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu 
705                 710                 715                 720 


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg 
                725                 730                 735     


Ile Val Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys 
            740                 745                 750         


Phe Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp 
        755                 760                 765             


Thr Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
    770                 775                 780         


<210>  108
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Met Gly Asn Arg His Ala Lys Ala Ser 
                325                 330                 335     


Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys Lys Leu Asn Lys 
            340                 345                 350         


Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu 
        355                 360                 365             


Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys 
    370                 375                 380                 


Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys Ser Glu Leu Ser 
385                 390                 395                 400 


Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp Arg Pro Ser Glu 
                405                 410                 415     


Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly Leu Gly Thr Asp 
            420                 425                 430         


Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr Asn Lys Glu Ile 
        435                 440                 445             


Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu 
    450                 455                 460                 


Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile Leu Val 
465                 470                 475                 480 


Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp Val Asp Lys Asp 
                485                 490                 495     


Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg 
            500                 505                 510         


Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu Ala Lys Arg Ser 
        515                 520                 525             


Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly 
    530                 535                 540                 


Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln 
545                 550                 555                 560 


Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr 
                565                 570                 575     


Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu 
            580                 585                 590         


Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu Val Asp Leu Gln 
        595                 600                 605             


Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp 
    610                 615                 620                 


Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu Val Ala 
625                 630                 635                 640 


Leu Leu His 
            


<210>  109
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp Met Gly Asn Arg His Ala Lys 
            500                 505                 510         


Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys Lys Leu 
        515                 520                 525             


Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile Ile Glu 
    530                 535                 540                 


Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys 
545                 550                 555                 560 


Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys Ser Glu 
                565                 570                 575     


Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp Arg Pro 
            580                 585                 590         


Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly Leu Gly 
        595                 600                 605             


Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr Asn Lys 
    610                 615                 620                 


Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser 
625                 630                 635                 640 


Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile 
                645                 650                 655     


Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp Val Asp 
            660                 665                 670         


Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu 
        675                 680                 685             


Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu Ala Lys 
    690                 695                 700                 


Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu 
705                 710                 715                 720 


Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp 
                725                 730                 735     


Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp Cys Glu 
            740                 745                 750         


Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr 
        755                 760                 765             


Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu Val Asp 
    770                 775                 780                 


Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu 
785                 790                 795                 800 


Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu 
                805                 810                 815     


Val Ala Leu Leu His 
            820     


<210>  110
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His Met Gly Asn Arg 
305                 310                 315                 320 


His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala 
                325                 330                 335     


Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala 
            340                 345                 350         


Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile 
        355                 360                 365             


Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu 
    370                 375                 380                 


Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys 
                405                 410                 415     


Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg 
            420                 425                 430         


Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe 
        435                 440                 445             


Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu 
    450                 455                 460                 


Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp 
465                 470                 475                 480 


Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp 
                485                 490                 495     


Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val 
            500                 505                 510         


Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr 
        515                 520                 525             


Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr 
    530                 535                 540                 


Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln 
545                 550                 555                 560 


Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly 
                565                 570                 575     


Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala 
            580                 585                 590         


Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln 
        595                 600                 605             


Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg 
    610                 615                 620                 


Lys Leu Leu Val Ala Leu Leu His 
625                 630         


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111

Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Ser Gly 
1               5                   10          


<210>  112
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Ser Gly Lys Leu Ala 
                325                 330                 335     


Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala 
            340                 345                 350         


Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
        355                 360                 365             


Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr Ala Gln 
    370                 375                 380                 


Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu 
385                 390                 395                 400 


Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln Val Ile 
                405                 410                 415     


Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg 
            420                 425                 430         


Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile 
        435                 440                 445             


Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln Thr Tyr 
    450                 455                 460                 


Gln Gln Gln Tyr Gly Arg Arg Leu Glu Asp Asp Ile Arg Ser Asp Thr 
465                 470                 475                 480 


Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg 
                485                 490                 495     


Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln 
            500                 505                 510         


Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu Val Lys 
        515                 520                 525             


Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val 
    530                 535                 540                 


Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile 
545                 550                 555                 560 


Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val 
                565                 570                 575     


Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys 
            580                 585                 590         


Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg Val Met 
        595                 600                 605             


Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys 
    610                 615                 620                 


Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser 
625                 630                 635                 640 


Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
                645                 650                 655 


<210>  113
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Ser Gly Lys Leu Ala Gln 
                325                 330                 335     


Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala 
            340                 345                 350         


Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu 
        355                 360                 365             


Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln 
    370                 375                 380                 


Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp 
385                 390                 395                 400 


Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala 
                405                 410                 415     


Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala 
            420                 425                 430         


Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala 
        435                 440                 445             


Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu 
    450                 455                 460                 


Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly 
465                 470                 475                 480 


Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro 
                485                 490                 495     


Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu 
            500                 505                 510         


Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile 
        515                 520                 525             


Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp 
    530                 535                 540                 


Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg 
545                 550                 555                 560 


Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser 
                565                 570                 575     


Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met 
            580                 585                 590         


Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser 
        595                 600                 605             


Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn 
    610                 615                 620                 


Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp 
625                 630                 635                 640 


Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
                645                 650             


<210>  114
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro Gly Ser Leu Glu Val Leu Phe Gln Gly 
                325                 330                 335     


Pro Ser Gly Lys Leu Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly 
            340                 345                 350         


Val Thr Val Lys Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu 
        355                 360                 365             


Thr Leu Tyr Lys Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile 
    370                 375                 380                 


Ile Asp Val Leu Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala 
385                 390                 395                 400 


Lys Ser Phe Lys Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys 
                405                 410                 415     


Ser Glu Leu Ser Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr 
            420                 425                 430         


Pro Pro Tyr Arg Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly 
        435                 440                 445             


Leu Gly Thr Lys Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr 
    450                 455                 460                 


Lys Asn Gln Leu Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly 
465                 470                 475                 480 


Ser Ser Leu Glu Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu 
                485                 490                 495     


Arg Ile Leu Val Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser 
            500                 505                 510         


Phe Val Asp Pro Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala 
        515                 520                 525             


Ala Gly Glu Lys Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile 
    530                 535                 540                 


Leu Cys Thr Arg Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr 
545                 550                 555                 560 


Glu Lys Ile Ala Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr 
                565                 570                 575     


His Gly Ser Leu Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln 
            580                 585                 590         


Asn Leu His Ser Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly 
        595                 600                 605             


Ala Gly Thr Arg Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser 
    610                 615                 620                 


Glu Ile Asp Leu Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys 
                645                 650                 655     


Asn Ala Leu Leu Ser Leu Val Gly Ser Asp Pro 
            660                 665         


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115

Gly Gly Gly Gly Ser 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116

Glu Ala Ala Ala Lys 
1               5   


