                         SEQUENCE LISTING

<110>  Bayer Schering Pharma AG
 
<120>  Neutralizing Prolactin Receptor Antibodies

<130>  53788

<150>  EP09075546.3
<151>  2009-12-10

<160>  73  

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Asp Asp Tyr Gly Met Ser Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Ala Asn Tyr Gly Leu Thr Trp 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Ser Ser Tyr Gly Met His Trp 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Glu Asp His Gly Met Ser Trp 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Ser Ser Tyr Trp Met Ser Trp 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Ser Ser Tyr Trp Met His Trp 
1               5               


<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Val Ile Ser Phe Asn Gly Asp Lys Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  10
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Leu Ile Ser Trp Asp Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  11
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Ser Val Ser Asp Thr Gly Thr Asp Thr His Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  12
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Asp Ile Ser Ser Ala Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ser Pro Leu Glu Ser Pro Val Ala Phe Asp Ile 
1               5                   10          


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ala Arg Gly Gly Asp Phe Asp Tyr 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Thr Ser Leu Arg Ala Thr Ala Phe Asp Thr 
1               5                   10      


<210>  16
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Lys Thr Pro Leu Ala Tyr Ser Ser Gly Trp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Arg Gly Leu Asp Ala Arg Arg Met Asp Tyr 
1               5                   10      


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Gly Ser Tyr Ser Asn Ile Gly Gly Asn Pro Val Asn 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asp Val Tyr 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  23
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  23

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Asn Tyr Gln Arg Pro Ser 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Cys Gln Ser Tyr Asp Thr Gly Leu Ser Gly Trp 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser 
1               5                   10      


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Trp 
1               5                   10          


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp 
1               5                   10      


<210>  34
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Glu Ser Pro Val Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Ile Val Ser Ser 
        115                 


<210>  35
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Tyr 
            20                  25                  30          


Gly Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asn Gly Asp Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Glu Ser Pro Val Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  37
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp His 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Ser Leu Arg Ala Thr Ala Phe Asp Thr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Asp Thr Gly Thr Asp Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Pro Leu Ala Tyr Ser Ser Gly Trp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  39
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Ser Ala Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Ala Arg Arg Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  40
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Gly Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  41
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Tyr Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  42
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Asp Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  43
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  44
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  45
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  46
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  46
caggtggaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct    120

ccagggaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attcccagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagtcccctt    300

gaaagtcccg tcgcttttga tatctggggc caagggacaa tggtcatcgt gagctca       357


<210>  47
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  47
caggtggaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcgct aactacggcc tgacctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtggcagtt atatcattta atggagacaa aaaatattac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagtcccctt    300

gaaagtcccg tcgcttttga tatctggggc caaggtaccc tggtcaccgt gagctca       357


<210>  48
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  48
caggtggaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtatcgggt gttagttgga atggcagtag gacgcactat    180

gcagactctg tgaagggccg actcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagaggaggg    300

gactttgact actggggcca aggtaccctg gtcaccgtga gctca                    345


<210>  49
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  49
caggtggaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttgag gatcatggca tgagctgggt ccgccaagct    120

ccagggaagg ggctggagtg ggtctctctt attagttggg atgatggaag taataaatac    180

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg    240

tatctgcaaa tgaacagcct gagagccgag gacactgccg tgtattactg tgcgacttcc    300

ctacgggcca cggcttttga tacgtggggc caaggtacac tggtcaccgt gagctca       357


<210>  50
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  50
caggtggaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcaagt gttagcgata ctggtactga tactcattac    180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc aaaaacccct    300

ctcgcatata gcagtggctg gtactacttt gactactggg gccaaggtac cctggtcacc    360

gtgagctca                                                            369


<210>  51
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  51
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctactgga tgcactgggt ccgccaagct    120

ccagggaagg ggctggagtg ggtttcagac attagcagtg ctagtagtta cacaaactac    180

gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gaggggtttg    300

gatgcgcgac ggatggacta ctggggccaa ggtaccctgg tcaccgtgag ctca          354


<210>  52
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  52
gatatcgtgc tgactcagcc accctcagcg tctgggaccc ctgggcagag ggtcaccatc     60

tcttgttctg gaagcaactc caacatcgga agtaatcctg taaactggta tcagcagctc    120

ccaggaacgg cccccaaact cctcatctat gacaataata agcgaccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgccag tcctatgaca ccggcctgag tggttgggtg    300

ttcggcggag gaaccaagtt aaccgtccta ggtcag                              336


<210>  53
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  53
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttccg gaagctactc caacatcggg ggtaatcctg taaactggta tcagcagctc    120

ccaggaacgg cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggttcggta    300

ttcggcggag gaaccaagct gacggtccta ggtcag                              336


<210>  54
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  54
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caatatcgga agtaatgatg tatattggta tcagcagctc    120

ccaggaacgg cccccaaact cctcatctat gacaataata agcgaccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggttcttgg    300

gtgttcggcg gaggaaccaa gctgacggtc ctaggtcag                           339


<210>  55
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  55
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta tcagcagctc    120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg    300

ttcggcggag gaaccaagtt aaccgtccta ggtcag                              336


<210>  56
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  56
gatatcgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc    120

ccaggaacgg cccccaaact cctcatctat agaaattatc agcgaccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggttcggtg    300

ttcggcggag gaaccaagtt aaccgtccta ggtcag                              336


<210>  57
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  57
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcctgcactg ggagcagctc caacattggg gcgggttatg ttgtacattg gtatcagcag    120

ctcccaggaa cggcccccaa actcctcatc tataggaata atcagcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc    240

cggtccgagg atgaggctga ttattactgt gcagcatggg atgacagcct gaatggttgg    300

ctgttcggcg gaggaaccaa gttaaccgtc ctaggtcag                           339


<210>  58
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Gly Asn Tyr Tyr Ala Thr Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  59
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Gly Asn Tyr Tyr Ala Thr Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  60
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  60

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Arg Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  61
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  61

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Pro Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  62

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Pro Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  63
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Arg Tyr Thr Gly Val Pro Asp Arg Leu Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105             


<210>  64
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  64
gaggtgcagc tcgtggagtc tggcggcgga ctggtgcagc ctggcggcag cctgagactg     60

agctgcgccg tgagcggctt caccttcagc agctacggca tgagctgggt gcgccaggct    120

cctggcaagg gactggaatg ggtggccacc gtgtccagcg gcggcaccta cacctactac    180

cccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagacaccgg    300

ggcaactact acgccaccta ctactatgcc atggactact ggggccaggg caccctggtg    360

accgtgagct ca                                                        372


<210>  65
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  65
gaggtgcagc tcgtggagtc tggcggcgac ctggtgaagc ctggcggcag cctgaagctg     60

tcctgcgccg tgagcggctt caccttcagc agctacggca tgagctgggt gcgccagacc    120

cccgacaaga gactggaatg ggtggcaacc gtgtctagcg gcggcaccta cacctactac    180

cccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac    240

ctgcagatgt ccagcctgaa gtccgaggac agcgccatgt actattgcgc cagacatcgg    300

ggcaactact acgccaccta ctactatgcc atggactact ggggccaggg caccagcgtg    360

accgtgagct ca                                                        372


<210>  66
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  66
gacgtgcagc tcgtggagtc tggcggcgga ctggtgcagc ctggcggaag ccggaaactg     60

tcctgcgctg ccagcggctt cgccttcagc agcttcggca tgcagtgggt gcgccaggcc    120

cccgagaagg gcctggaatg ggtggcctac atcagcagcg gcagcagcac catctactac    180

gccgacaccg tgaagggccg gttcaccatc agcagagaca accccaagaa taccctgttc    240

ctgcagatga ccagcctgcg gagcgaggac accgccatgt actactgcgt gcggagcggc    300

agagactact ggggccaggg caccagcgtg accgtgagct ca                       342


<210>  67
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  67
gatatcgtgc tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc     60

atcaactgca aggccagcaa gtccgtgagc accagcggct acacctacat gcactggtat    120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggccagcaa ccgggagagc    180

ggcgtgcccg accggtttag cggcagcggc tccggcaccg acttcaccct gaccatcagc    240

cccgtgcagg ccgaggacgt ggccacctac tactgccagc acagcggcga gctgcccccc    300

agcttcggcc agggcaccaa gctggaaatc aagcgggcc                           339


<210>  68
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  68
gatatcgtgc tgacccagag ccccgccagc ctggctgtgt ctctgggcca gggcgccacc     60

atcagctgcc gggccagcaa gtccgtgagc accagcggct acacctacat gcactggtat    120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggccagcaa cctggaaagc    180

ggcgtgcccg ccagattcag cggcagcggc tccggcaccg acttcaccct gaacatccac    240

cccgtggagg aagaggacgc cgccacctac tactgccagc acagcggcga gctgccccct    300

agctttggcg gcggaacaaa gctggaaatc aagcgggcc                           339


<210>  69
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  maturated PRLR antibody

<400>  69
agcatcgtga tgacccagac ccccaagttc ctgctggtgt ctgccggcga cagagtgacc     60

atcacctgca aggccagcca gggcgtgagc aacgacgtgg cctggttcca gcagaagccc    120

ggccagagcc ccaagctgct gatctacagc gccagcaccc ggtacaccgg cgtgcccgac    180

agactgaccg gctccggcta cggcaccgat ttcaccttca ccatcaacac cgtgcaggcc    240

gaggacctgg ccgtgtactt ctgccagcag gactacacca gccccacctt tggcggcgga    300

acaaagctgg aaatcaagcg ggcc                                           324


<210>  70
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Leu Pro Pro Gly Lys Pro Glu Ile Phe Lys Cys Arg Ser Pro Asn 
1               5                   10                  15      


Lys Glu Thr Phe Thr Cys Trp Trp Arg Pro Gly Thr Asp Gly Gly Leu 
            20                  25                  30          


Pro Thr Asn Tyr Ser Leu Thr Tyr His Arg Glu Gly Glu Thr Leu Met 
        35                  40                  45              


His Glu Cys Pro Asp Tyr Ile Thr Gly Gly Pro Asn Ser Cys His Phe 
    50                  55                  60                  


Gly Lys Gln Tyr Thr Ser Met Trp Arg Thr Tyr Ile Met Met Val Asn 
65                  70                  75                  80  


Ala Thr Asn Gln Met Gly Ser Ser Phe Ser Asp Glu Leu Tyr Val Asp 
                85                  90                  95      


Val Thr Tyr Ile Val Gln Pro Asp Pro Pro Leu Glu Leu Ala Val Glu 
            100                 105                 110         


Val Lys Gln Pro Glu Asp Arg Lys Pro Tyr Leu Trp Ile Lys Trp Ser 
        115                 120                 125             


Pro Pro Thr Leu Ile Asp Leu Lys Thr Gly Trp Phe Thr Leu Leu Tyr 
    130                 135                 140                 


Glu Ile Arg Leu Lys Pro Glu Lys Ala Ala Glu Trp Glu Ile His Phe 
145                 150                 155                 160 


Ala Gly Gln Gln Thr Glu Phe Lys Ile Leu Ser Leu His Pro Gly Gln 
                165                 170                 175     


Lys Tyr Leu Val Gln Val Arg Cys Lys Pro Asp His Gly Tyr Trp Ser 
            180                 185                 190         


Ala Trp Ser Pro Ala Thr Phe Ile Gln Ile Pro Ser Asp Phe Thr Met 
        195                 200                 205             


Asn Asp Ile Glu Gly Arg Met Asp His His His His His His 
    210                 215                 220         


<210>  71
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  71
cagttacctc ctggaaaacc tgagatcttt aaatgtcgtt ctcccaataa ggaaacattc     60

acctgctggt ggaggcctgg gacagatgga ggacttccta ccaattattc actgacttac    120

cacagggaag gagagacact catgcatgaa tgtccagact acataaccgg tggccccaac    180

tcctgccact ttggcaagca gtacacctcc atgtggagga catacatcat gatggtcaat    240

gccactaacc agatgggaag cagtttctcg gatgaacttt atgtggacgt gacttacata    300

gttcagccag accctccttt ggagctggct gtggaagtaa aacagccaga agacagaaaa    360

ccctacctgt ggattaaatg gtctccacct accctgattg acttaaaaac tggttggttc    420

acgctcctgt atgaaattcg attaaaaccc gagaaagcag ctgagtggga gatccatttt    480

gctgggcagc aaacagagtt taagattctc agcctacatc caggacagaa ataccttgtc    540

caggttcgct gcaaaccaga ccatggatac tggagtgcat ggagtccagc gaccttcatt    600

cagataccta gtgacttcac catgaatgat atcgagggcc gcatggacca ccaccaccac    660

caccac                                                               666


<210>  72
<211>  222
<212>  PRT
<213>  Mus musculus

<400>  72

Gln Ser Pro Pro Gly Lys Pro Glu Ile His Lys Cys Arg Ser Pro Asp 
1               5                   10                  15      


Lys Glu Thr Phe Thr Cys Trp Trp Asn Pro Gly Ser Asp Gly Gly Leu 
            20                  25                  30          


Pro Thr Asn Tyr Ser Leu Thr Tyr Ser Lys Glu Gly Glu Lys Asn Thr 
        35                  40                  45              


Tyr Glu Cys Pro Asp Tyr Lys Thr Ser Gly Pro Asn Ser Cys Phe Phe 
    50                  55                  60                  


Ser Lys Gln Tyr Thr Ser Ile Trp Lys Ile Tyr Ile Ile Thr Val Asn 
65                  70                  75                  80  


Ala Thr Asn Glu Met Gly Ser Ser Thr Ser Asp Pro Leu Tyr Val Asp 
                85                  90                  95      


Val Thr Tyr Ile Val Glu Pro Glu Pro Pro Arg Asn Leu Thr Leu Glu 
            100                 105                 110         


Val Lys Gln Leu Lys Asp Lys Lys Thr Tyr Leu Trp Val Lys Trp Leu 
        115                 120                 125             


Pro Pro Thr Ile Thr Asp Val Lys Thr Gly Trp Phe Thr Met Glu Tyr 
    130                 135                 140                 


Glu Ile Arg Leu Lys Ser Glu Glu Ala Asp Glu Trp Glu Ile His Phe 
145                 150                 155                 160 


Thr Gly His Gln Thr Gln Phe Lys Val Phe Asp Leu Tyr Pro Gly Gln 
                165                 170                 175     


Lys Tyr Leu Val Gln Thr Arg Cys Lys Pro Asp His Gly Tyr Trp Ser 
            180                 185                 190         


Arg Trp Gly Gln Glu Lys Ser Ile Glu Ile Pro Asn Asp Phe Thr Leu 
        195                 200                 205             


Lys Asp Ile Glu Gly Arg Met Asp His His His His His His 
    210                 215                 220         


<210>  73
<211>  666
<212>  DNA
<213>  Mus musculus

<400>  73
cagtcaccac ctggaaaacc tgaaatccac aaatgtcgtt cccctgacaa ggaaacattc     60

acctgctggt ggaatcctgg gtcagatgga ggactcccca ccaattattc attgacatac    120

agcaaagaag gagagaaaaa cacctatgaa tgtccagact acaaaaccag tggccccaat    180

tcctgtttct ttagcaagca gtacacttcc atatggaaaa tatacatcat cacagtaaat    240

gccacgaacg aaatgggaag cagtacctcg gatccacttt atgtggatgt gacttacatt    300

gttgaaccag agcctcctcg gaacctgact ttagaagtga aacaactaaa agacaaaaaa    360

acatatctgt gggtaaaatg gttgccacct accataactg atgtaaaaac tggttggttt    420

acaatggaat atgaaattcg attaaagtct gaagaagcag atgagtggga gatccacttc    480

acaggtcatc aaacacaatt taaggttttt gacttatatc caggacaaaa gtatcttgtc    540

cagactcgct gcaagccaga ccatggatac tggagtagat ggggccagga gaaatctatt    600

gaaataccaa atgacttcac cttgaaagac atcgagggcc gcatggacca ccaccaccac    660

caccac                                                               666


