
                                SEQUENCE LISTING

<110> Regeneron Pharmaceuticals, Inc.

<120> MICE THAT MAKE HEAVY CHAIN ANTIBODIES
  

<130> 0761A-WO

<140> To be assigned      
<141> 2010-12-10  

<150> 61/285,250          
<151> 2009-12-10  

<160> 64

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 1
tcaccatgga ctggacctgg a                                           21

<210> 2
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 2
cccatcaact cacactcttg tccaggggcc tgtcgaaacc                       40

<210> 3
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 3
ctggtttcga caggcccctg gacaagagtg tgagttgatg                       40

<210> 4
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 4
acgttccgga tgaggagacg gtgaccaggg ttc                              33

<210> 5
<211> 1449
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 5
atggactgga cctggaggat ccttttcttg gtggcagcag ccacaggagc ccactcccag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct 180
ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca 240
cagaagtttc agggcagggt caccatgacc ggggacacgt ccatcagcac agcctacatg 300
gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag aggctcctta 360
tattgtacta atggtgtatg ctttgactac tggggccagg gaaccctggt caccgtctcc 420
tcaaagcttt ccaaaacaac acccccatca gtctatccac tggcccctgg gtgtggagat 480
acaactggtt cctccgtgac tctgggatgc ctggtcaagg gctacttccc tgagtcagtg 540
actgtgactt ggaactctgg atccctgtcc agcagtgtgc acaccttccc agctctcctg 600
cagtctggac tctacactat gagcagctca gtgactgtcc cctccagcac ttggccaagt 660
cagaccgtca cctgcagcgt tgctcaccca gccagcagca ccacggtgga caaaaaactt 720
gtccggagcg agcccagcgg gcccatttca acaatcaacc cctgtcctcc atgcaaggag 780
tgtcacaaat gcccagctcc taacctcgag ggtggaccat ccgtcttcat cttccctcca 840
aatatcaagg atgtactcat gatctccctg acacccaagg tcacgtgtgt ggtggtggat 900
gtgagcgagg atgacccaga cgtccagatc agctggtttg tgaacaacgt ggaagtacac 960
acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagcacc 1020
ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac 1080
aaagacctcc catcacccat cgagagaacc atctcaaaaa ttaaagggct agtcagagct 1140
ccacaagtat acatcttgcc gccaccagca gagcagttgt ccaggaaaga tgtcagtctc 1200
acttgcctgg tcgtgggctt caaccctgga gacatcagtg tggagtggac cagcaatggg 1260
catacagagg agaactacaa ggacaccgca ccagtcctgg actctgacgg ttcttacttc 1320
atatatagca agctcaatat gaaaacaagc aagtgggaga aaacagattc cttctcatgc 1380
aacgtgagac acgagggtct gaaaaattac tacctgaaga agaccatctc ccggtctccg 1440
ggtaaatga                                                         1449

<210> 6
<211> 482
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 6
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Cys Thr Asn Gly Val Cys Phe
        115                 120                 125             
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Leu Ser
    130                 135                 140                 
Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp
145                 150                 155                 160 
Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe
                165                 170                 175     
Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser
            180                 185                 190         
Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser
        195                 200                 205             
Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr
    210                 215                 220                 
Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu
225                 230                 235                 240 
Val Arg Ser Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro
                245                 250                 255     
Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly
            260                 265                 270         
Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile
        275                 280                 285             
Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp
    290                 295                 300                 
Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His
305                 310                 315                 320 
Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg
                325                 330                 335     
Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys
            340                 345                 350         
Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu
        355                 360                 365             
Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr
    370                 375                 380                 
Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu
385                 390                 395                 400 
Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp
                405                 410                 415     
Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val
            420                 425                 430         
Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys
        435                 440                 445             
Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His
    450                 455                 460                 
Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro
465                 470                 475                 480 
Gly Lys
        


<210> 7
<211> 1449
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 7
atggactgga cctggaggat ccttttcttg gtggcagcag ccacaggagc ccactcccag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccggc tactatatgc actggtttcg acaggcccct 180
ggacaagagt gtgagttgat gggatggatc aaccctaaca gtggtggcac aaactatgca 240
cagaagtttc agggcagggt caccatgacc ggggacacgt ccatcagcac agcctacatg 300
gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag aggctcctta 360
tattgtacta atggtgtatg ctttgactac tggggccagg gaaccctggt caccgtctcc 420
tcaaagcttt ccaaaacaac acccccatca gtctatccac tggcccctgg gtgtggagat 480
acaactggtt cctccgtgac tctgggatgc ctggtcaagg gctacttccc tgagtcagtg 540
actgtgactt ggaactctgg atccctgtcc agcagtgtgc acaccttccc agctctcctg 600
cagtctggac tctacactat gagcagctca gtgactgtcc cctccagcac ttggccaagt 660
cagaccgtca cctgcagcgt tgctcaccca gccagcagca ccacggtgga caaaaaactt 720
gtccggagcg agcccagcgg gcccatttca acaatcaacc cctgtcctcc atgcaaggag 780
tgtcacaaat gcccagctcc taacctcgag ggtggaccat ccgtcttcat cttccctcca 840
aatatcaagg atgtactcat gatctccctg acacccaagg tcacgtgtgt ggtggtggat 900
gtgagcgagg atgacccaga cgtccagatc agctggtttg tgaacaacgt ggaagtacac 960
acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagcacc 1020
ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac 1080
aaagacctcc catcacccat cgagagaacc atctcaaaaa ttaaagggct agtcagagct 1140
ccacaagtat acatcttgcc gccaccagca gagcagttgt ccaggaaaga tgtcagtctc 1200
acttgcctgg tcgtgggctt caaccctgga gacatcagtg tggagtggac cagcaatggg 1260
catacagagg agaactacaa ggacaccgca ccagtcctgg actctgacgg ttcttacttc 1320
atatatagca agctcaatat gaaaacaagc aagtgggaga aaacagattc cttctcatgc 1380
aacgtgagac acgagggtct gaaaaattac tacctgaaga agaccatctc ccggtctccg 1440
ggtaaatga                                                         1449

<210> 8
<211> 482
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 8
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Phe Arg Gln Ala Pro Gly Gln Glu Cys
    50                  55                  60                  
Glu Leu Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Cys Thr Asn Gly Val Cys Phe
        115                 120                 125             
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Leu Ser
    130                 135                 140                 
Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp
145                 150                 155                 160 
Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe
                165                 170                 175     
Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser
            180                 185                 190         
Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser
        195                 200                 205             
Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr
    210                 215                 220                 
Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu
225                 230                 235                 240 
Val Arg Ser Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro
                245                 250                 255     
Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly
            260                 265                 270         
Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile
        275                 280                 285             
Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp
    290                 295                 300                 
Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His
305                 310                 315                 320 
Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg
                325                 330                 335     
Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys
            340                 345                 350         
Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu
        355                 360                 365             
Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr
    370                 375                 380                 
Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu
385                 390                 395                 400 
Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp
                405                 410                 415     
Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val
            420                 425                 430         
Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys
        435                 440                 445             
Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His
    450                 455                 460                 
Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro
465                 470                 475                 480 
Gly Lys
        


<210> 9
<211> 1149
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 9
atggactgga cctggaggat ccttttcttg gtggcagcag ccacaggagc ccactcccag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct 180
ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca 240
cagaagtttc agggcagggt caccatgacc ggggacacgt ccatcagcac agcctacatg 300
gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag aggctcctta 360
tattgtacta atggtgtatg ctttgactac tggggccagg gaaccctggt caccgtctcc 420
tcatccggag agcccagcgg gcccatttca acaatcaacc cctgtcctcc atgcaaggag 480
tgtcacaaat gcccagctcc taacctcgag ggtggaccat ccgtcttcat cttccctcca 540
aatatcaagg atgtactcat gatctccctg acacccaagg tcacgtgtgt ggtggtggat 600
gtgagcgagg atgacccaga cgtccagatc agctggtttg tgaacaacgt ggaagtacac 660
acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagcacc 720
ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac 780
aaagacctcc catcacccat cgagagaacc atctcaaaaa ttaaagggct agtcagagct 840
ccacaagtat acatcttgcc gccaccagca gagcagttgt ccaggaaaga tgtcagtctc 900
acttgcctgg tcgtgggctt caaccctgga gacatcagtg tggagtggac cagcaatggg 960
catacagagg agaactacaa ggacaccgca ccagtcctgg actctgacgg ttcttacttc 1020
atatatagca agctcaatat gaaaacaagc aagtgggaga aaacagattc cttctcatgc 1080
aacgtgagac acgagggtct gaaaaattac tacctgaaga agaccatctc ccggtctccg 1140
ggtaaatga                                                         1149

<210> 10
<211> 382
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 10
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Cys Thr Asn Gly Val Cys Phe
        115                 120                 125             
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Glu
    130                 135                 140                 
Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu
145                 150                 155                 160 
Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe
                165                 170                 175     
Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro
            180                 185                 190         
Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val
        195                 200                 205             
Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr
    210                 215                 220                 
Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr
225                 230                 235                 240 
Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys
                245                 250                 255     
Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser
            260                 265                 270         
Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro
        275                 280                 285             
Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val
    290                 295                 300                 
Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly
305                 310                 315                 320 
His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp
                325                 330                 335     
Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp
            340                 345                 350         
Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys
        355                 360                 365             
Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys
    370                 375                 380         


<210> 11
<211> 1149
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 11
atggactgga cctggaggat ccttttcttg gtggcagcag ccacaggagc ccactcccag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccggc tactatatgc actggtttcg acaggcccct 180
ggacaagagt gtgagttgat gggatggatc aaccctaaca gtggtggcac aaactatgca 240
cagaagtttc agggcagggt caccatgacc ggggacacgt ccatcagcac agcctacatg 300
gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag aggctcctta 360
tattgtacta atggtgtatg ctttgactac tggggccagg gaaccctggt caccgtctcc 420
tcatccggag agcccagcgg gcccatttca acaatcaacc cctgtcctcc atgcaaggag 480
tgtcacaaat gcccagctcc taacctcgag ggtggaccat ccgtcttcat cttccctcca 540
aatatcaagg atgtactcat gatctccctg acacccaagg tcacgtgtgt ggtggtggat 600
gtgagcgagg atgacccaga cgtccagatc agctggtttg tgaacaacgt ggaagtacac 660
acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagcacc 720
ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac 780
aaagacctcc catcacccat cgagagaacc atctcaaaaa ttaaagggct agtcagagct 840
ccacaagtat acatcttgcc gccaccagca gagcagttgt ccaggaaaga tgtcagtctc 900
acttgcctgg tcgtgggctt caaccctgga gacatcagtg tggagtggac cagcaatggg 960
catacagagg agaactacaa ggacaccgca ccagtcctgg actctgacgg ttcttacttc 1020
atatatagca agctcaatat gaaaacaagc aagtgggaga aaacagattc cttctcatgc 1080
aacgtgagac acgagggtct gaaaaattac tacctgaaga agaccatctc ccggtctccg 1140
ggtaaatga                                                         1149

<210> 12
<211> 382
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 12
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Phe Arg Gln Ala Pro Gly Gln Glu Cys
    50                  55                  60                  
Glu Leu Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Cys Thr Asn Gly Val Cys Phe
        115                 120                 125             
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Glu
    130                 135                 140                 
Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu
145                 150                 155                 160 
Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe
                165                 170                 175     
Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro
            180                 185                 190         
Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val
        195                 200                 205             
Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr
    210                 215                 220                 
Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr
225                 230                 235                 240 
Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys
                245                 250                 255     
Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser
            260                 265                 270         
Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro
        275                 280                 285             
Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val
    290                 295                 300                 
Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly
305                 310                 315                 320 
His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp
                325                 330                 335     
Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp
            340                 345                 350         
Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys
        355                 360                 365             
Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys
    370                 375                 380         


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 13
caacacaagt gcgatgcac                                              19

<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 14
gattagcctc catgcctact c                                           21

<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 15
gatgatcatg tgggtagacc t                                           21

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 16
tctatgctat ctcagtgcta                                             20

<210> 17
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 17
tgacagtgta atcacatata ctttttcttg tagtcccaga agtatcatc             49

<210> 18
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 18
gaggtccagc ttcagcagtc tggagctgag ctggtgaggc ctgggtcctc agtgaagatg 60
tcctgcaaga cttctggata tacattcaca agctacggta taaactgggt gaagcagagg 120
cctggacagg gcctggaatg gattggatat atttatattg gaaatggtta tactgagtac 180
aatgagaagt tcaagggcaa ggccacactg acttcagaca catcctccag cacagcctac 240
atgcagctca gcagcctgac atctgaggac tctgcaatct atttccgtgc aagaggacgg 300
gtcggcccgt actactttga ctactggggc caaggcacca ctctcacagt ctcctcagtc 360
ccagaagtat catctgtctt catc                                        384

<210> 19
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 19
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Ile Gly Asn Gly Tyr Thr Glu Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Arg
                85                  90                  95      
Ala Arg Gly Arg Val Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120                 125             


<210> 20
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 20
gaggtccagc tgcaacagtc tggacgtgag ctggtcaagc ctggggcttc agtgatgata 60
tcttgtacgg cttctggata cacgttcatt gactacttca taaactggat gaagcggagc 120
catggacaga gccttgagtg gattggagat attaatccta acaatggtgg ttctaactac 180
aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac 240
atggatctcc gcagcctgac atctgaagac tctgcagtct attactgtgc aaaactggga 300
cgggactggt acttcgatgt ctggggcaca gggaccacgg tcaccgtctc ctcagtccca 360
gaagtatcat ctgtcttcat c                                           381

<210> 21
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 21
Glu Val Gln Leu Gln Gln Ser Gly Arg Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Met Ile Ser Cys Thr Ala Ser Gly Tyr Thr Phe Ile Asp Tyr
            20                  25                  30          
Phe Ile Asn Trp Met Lys Arg Ser His Gly Gln Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Ser Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Leu Gly Arg Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120                 125         


<210> 22
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 22
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcagtgggt aaaacagagg 120
cctggacagg gccttgagtg gatcggagag attgatcctt ctgatagcta tactaactac 180
aatcaaaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac 240
atgcagctca gcagcctgac acctgaggac tctgcggtct attactgtgc aagatgtagg 300
tactactttg actactgggg ccaaggcacc actctcacag tctcctcagt cccagaagta 360
tcatctgtct tcatc                                                  375

<210> 23
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 23
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Cys Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110         
Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120                 125 


<210> 24
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 24
gaggttcagt tgcagcagtc tggggcagag attgtgaagt caggggcctc agtcaagttg 60
tcctgcacag cttctggctt caacatgaaa gactacttta tccactgggt gaagcagagg 120
actgaacagg gcctggagtg gattggaagg cttgatcctg aggatggtaa aactaaatat 180
gccccgaaat tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac 240
ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtgc tagaggggga 300
ctgggacgtg aggaatacta tgctgtggac tactggggtc aaggaacctc agtcaccgtc 360
tcctcagtcc cagaagtatc atctgtcttc atc                              393

<210> 25
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 25
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Ile Val Lys Ser Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Met Lys Asp Tyr
            20                  25                  30          
Phe Ile His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Leu Asp Pro Glu Asp Gly Lys Thr Lys Tyr Ala Pro Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Leu Gly Arg Glu Glu Tyr Tyr Ala Val Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Pro Glu Val Ser Ser
        115                 120                 125             
Val Phe Ile
    130     


<210> 26
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 26
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc 60
acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag 120
tttccaggaa acaaactgga atggatgggc tacataagct acgatggtag gaataactac 180
aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc 240
ctgaagttga attctgtgac tactgaggac acagccacat attactgtgc aatccatacg 300
gtagtagggg actatgttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca 360
gtcccagaag tatcatctgt cttcatc                                     387

<210> 27
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 27
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Ile His Thr Val Val Gly Asp Tyr Val Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe
        115                 120                 125             
Ile
    


<210> 28
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 28
gaggttcagc tgcagcagtc tggggcagag cttgtgaggc caggggcctc agtcaagttg 60
tcctgcacag cttctggctt caacattaaa gactactata tacactgggt gaagaagagg 120
cctgaacagg gcctggagtg gattggaagg attgatcctg aggatggtga tactgagtat 180
gccccgaagt tccagggcaa ggccactatg actgcagaca catcctccaa cacagcctac 240
cttcagctca gcagcctgac atctgaggac attgccgtct attactgtac tacatctagg 300
cctttttatt ttgactactg gggccaaggc accactctca cagtctcctc agtcccagaa 360
gtatcatctg tcttcatc                                               378

<210> 29
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 29
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Lys Lys Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Tyr Ala Pro Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ile Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Thr Ser Arg Pro Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Leu Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120                 125     


<210> 30
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 30
gaggttcagc tgcagcagtc tgggacagaa cttgtgaagc caggggcctc agccaagttg 60
tcctgcacag cttctggctt caacgttaaa gactacttta tgcactgggt gaagcagaag 120
actgaacagg gcctggagtg gattggaagg attgttcctg aggatggtga aactaagtct 180
gccccgaaat tccaggacag gaccactata agaacagaca catcctccaa cacatctcac 240
ctacaactca acagcctgac atctgaggac actgccgtct attactgtgc tagacctaac 300
cccccttact ggggccaagg gactctggtc actgtctctg tagtcccaga agtatcatct 360
gtcttcatc                                                         369

<210> 31
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 31
Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Ala Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Lys Asp Tyr
            20                  25                  30          
Phe Met His Trp Val Lys Gln Lys Thr Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Val Pro Glu Asp Gly Glu Thr Lys Ser Ala Pro Lys Phe
    50                  55                  60                  
Gln Asp Arg Thr Thr Ile Arg Thr Asp Thr Ser Ser Asn Thr Ser His
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Pro Asn Pro Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Val Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120             


<210> 32
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 32
gaggtgaaac tggtggaatc tggaggaggc ttggttcagt ctgggcgttc tctgagactc 60
tcctgtgcaa cttctgggtt caccttcagt gatttctaca tggagtgggt ccgccaagct 120
ccagggaagg gactggagtg gattgctaca agtagaaaca aacttaatga ttatacacca 180
gaattcagtg catctgtgaa gggtcgattc atcgtctcca gagacacttc ccaaaacatc 240
ctctaccttc agatgaatgc cctgagacct gaggacactg ccatttatta ctgtgcaaga 300
gcctgtagtg actacgaccg ttactatgct atggactatt ggggtcaagg aacctcagtc 360
accgtctcct cagtcccaga agtatcatct gtcttcatc                        399

<210> 33
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 33
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe
            20                  25                  30          
Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Ala Thr Ser Arg Asn Lys Leu Asn Asp Tyr Thr Pro Glu Phe Ser Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Asn Ile
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Thr Ala Ile Tyr
                85                  90                  95      
Tyr Cys Ala Arg Ala Cys Ser Asp Tyr Asp Arg Tyr Tyr Ala Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Pro Glu Val
        115                 120                 125             
Ser Ser Val Phe Ile
    130             


<210> 34
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 34
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg 120
cctggacgag gccttgagtg gattggaagg attgatccta atagtggtgg tactaagtac 180
aatgagaagc tcaagaacaa ggccacactg actgtagaca aaccctccag cacagcctac 240
atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagagaggag 300
ataaattact acggtagtac ctacggtgct atggactact ggggtcaagg aacctcagtc 360
accgtctcct cagtcccaga agtatcatct gtcttcatc                        399

<210> 35
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 35
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Leu
    50                  55                  60                  
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Glu Ile Asn Tyr Tyr Gly Ser Thr Tyr Gly Ala Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Pro Glu Val
        115                 120                 125             
Ser Ser Val Phe Ile
    130             


<210> 36
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 36
gaggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctgcaagg cttctggtta ctcattcact ggctactaca tgaactgggt gaagcaaagt 120
cctgaaaaga gccttgagtg gattggagag attaatccta gcactggtgg tactacctac 180
aaccagaagt tcaaggccaa ggccacattg actgtagaca aatcctccag cacagcctac 240
atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aggtggttac 300
tggtacttcg atgtctgggg cacagggacc acggtcaccg tctcctcagt cccagaagta 360
tcatctgtct tcatc                                                  375

<210> 37
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 37
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val
            100                 105                 110         
Thr Val Ser Ser Val Pro Glu Val Ser Ser Val Phe Ile
        115                 120                 125 


<210> 38
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 38
gaggtgcagc tggtggagtc tgggggagac ttagtggagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact 120
ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctactat 180
ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatgat 300
tactacggta gtagctacgg gtggtacttc gatgtctggg gcacagggac cacggtcacc 360
gtctcctcag tcccagaagt atcatctgtc ttcatc                           396

<210> 39
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Glu Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Asp Tyr Tyr Gly Ser Ser Tyr Gly Trp Tyr Phe Asp Val
            100                 105                 110         
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Val Pro Glu Val Ser
        115                 120                 125             
Ser Val Phe Ile
    130         


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 40
cgatgggggc agggaaagct gcac                                        24

<210> 41
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 41
gtaaaacgac ggccag                                                 16

<210> 42
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 42
caggaaacag ctatgac                                                17

<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> variation      
<222> (14)...(14)
<223> s = c or g
      

<220> 
<223> synthetic
      

<400> 43
tcaccatgga ctgsacctgg a                                           21

<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> variation      
<222> (17)...(17)
<223> y = c or t

<220> 
<223> synthetic

<400> 44
ccatggacac actttgytcc ac                                          22

<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 45
tcaccatgga gtttgggctg agc                                         23

<210> 46
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> variation      
<222> (14)...(14)
<223> y = c or t

<220> 
<223> synthetic

<400> 46
agaacatgaa acayctgtgg ttctt                                       25

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 47
atggggtcaa ccgccatcct                                             20

<210> 48
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 48
acaatgtctg tctccttcct cat                                         23

<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 49
gcaaggctta caaccacaat c                                           21

<210> 50
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 50
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggatgg atgaacccta atagtggtaa gacaggctat 180
gcacagaagt tccagggcag agtcgccatg accaggaaaa cctccataag cacagcctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaggac 300
tacagtaact acggggactt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360
gtgcccaggg attgtggttg t                                           381

<210> 51
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Met Asn Pro Asn Ser Gly Lys Thr Gly Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Ala Met Thr Arg Lys Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Asp Tyr Ser Asn Tyr Gly Asp Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys
        115                 120                 125         


<210> 52
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 52
caggttcagc tggtgcagtc tggagctgag atgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacatactat 180
gcacagaacc tccagggcag agtcaccatg accacagaca catccacgag cgcagccttc 240
atggacctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatggg 300
tatagtacct cgtccttaga ctactggggc cagggaaccc tggtcaccgt ctcctcagtg 360
cccagggatt gtggttgt                                               378

<210> 53
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 53
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Tyr Tyr Ala Gln Asn Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Ala Ala Phe
65                  70                  75                  80  
Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Tyr Ser Thr Ser Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys
        115                 120                 125     


<210> 54
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 54
caggttcagc tggtgcagtc tggagctgag atgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacatactat 180
gcacagaacc tccagggcag agtcaccatg accacagaca catccacgag cgcagccttc 240
atggacctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatggg 300
tatagtacct cgtccttaga ctactggggc cagggaaccc tggtcaccgt ctcctcagtg 360
cccagggatt gtggttgt                                               378

<210> 55
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Tyr Tyr Ala Gln Asn Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Ala Ala Phe
65                  70                  75                  80  
Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Tyr Ser Thr Ser Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys
        115                 120                 125     


<210> 56
<211> 408
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 56
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat 180
gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac 240
atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgat 300
atgattacgt ttgggggagt tatcgccaac tactactact acggtatgga cgtctggggc 360
caagggacca cggtcaccgt cacctcagtg cccagggatt gtggttgt              408

<210> 57
<211> 136
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Met Ile Thr Phe Gly Gly Val Ile Ala Asn Tyr Tyr
            100                 105                 110         
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Thr
        115                 120                 125             
Ser Val Pro Arg Asp Cys Gly Cys
    130                 135     


<210> 58
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 58
caggttcagt tgctgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctacaagg cttctgatta cacctttacc agctatggta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat 180
gcacagaacc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac 240
atggaactga ggagcctgag atctgacgac tcggccgtgt attactgtgc gagagaggag 300
ctggaacttt ttgactactg gggccaggga accctggtca ccgtctcctc agtgcccagg 360
gattgtggtt gt                                                     372

<210> 59
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 59
Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Tyr Lys Ala Ser Asp Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Glu Leu Glu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys
        115                 120                 


<210> 60
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 60
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac 180
gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggg 300
tatagtacct cgtccttaga ctactggggc cagggaaccc tggtcaccgt ctcctcagtg 360
cccagggatt gtggttgt                                               378

<210> 61
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Tyr Ser Thr Ser Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys
        115                 120                 125     


<210> 62
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 62
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac 180
gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ggttatagca 300
gtggctggta cctactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360
gtctccttag tgcccaggga ttgtggttgt                                  390

<210> 63
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic
      

<400> 63
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Val Ile Ala Val Ala Gly Thr Tyr Tyr Tyr Tyr Gly Met Asp Val
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Leu Val Pro Arg Asp Cys
        115                 120                 125             
Gly Cys
    130 


<210> 64
<211> 101
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 64
tgacagtgta atcacatata ctttttcttg tagtgcccag ggattgtggt tgtaagcctt 60
gcatatgtac aggtaagtca gtaggccttt caccctgacc c                     101
