                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  THERAPEUTIC USES OF SOLUBLE ALPHA-KLOTHO

<130>  X-18572

<150>  61/286880
<151>  2009-12-16

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1014
<212>  PRT
<213>  Mus musculus

<400>  1

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp 
                565                 570                 575     


Phe Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Thr Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met 
    610                 615                 620                 


Ile Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Ala Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala 
            660                 665                 670         


Asn Leu Cys Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr 
        675                 680                 685             


Met Asn Glu Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His 
    690                 695                 700                 


Leu Leu Arg Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe 
705                 710                 715                 720 


Arg Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg 
785                 790                 795                 800 


Gly Ser Phe Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Trp Glu Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp 
865                 870                 875                 880 


Pro His Ala Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr 
                885                 890                 895     


Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly 
        915                 920                 925             


Phe Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys 
    930                 935                 940                 


His Tyr Arg Arg Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr 
945                 950                 955                 960 


Leu Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly 
                965                 970                 975     


Phe Phe Gln Thr Arg Lys Ser Leu Leu Val Phe Ile Ser Phe Leu Val 
            980                 985                 990         


Phe Thr Phe Ile Ile Ser Leu Ala  Leu Ile Phe His Tyr  Ser Lys Lys 
        995                 1000                 1005             


Gly Gln  Arg Ser Tyr Lys 
    1010                 


<210>  2
<211>  966
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala Arg 
            20                  25                  30          


Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro Asp 
        35                  40                  45              


Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly 
    50                  55                  60                  


Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His 
65                  70                  75                  80  


His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro Ser 
                85                  90                  95      


Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser Asp 
            100                 105                 110         


Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu Gly 
        115                 120                 125             


Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn 
    130                 135                 140                 


Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg 
145                 150                 155                 160 


Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu 
                165                 170                 175     


Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly Trp 
            180                 185                 190         


Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys 
        195                 200                 205             


Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn 
    210                 215                 220                 


Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro 
225                 230                 235                 240 


Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn Leu 
                245                 250                 255     


Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg 
            260                 265                 270         


Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp Ile 
        275                 280                 285             


Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys Ser 
    290                 295                 300                 


Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly 
305                 310                 315                 320 


Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp 
                325                 330                 335     


Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Asn 
        355                 360                 365             


Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser 
    370                 375                 380                 


Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu Asn 
385                 390                 395                 400 


Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met 
                405                 410                 415     


Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu 
            420                 425                 430         


Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly 
        435                 440                 445             


Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val 
    450                 455                 460                 


Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala Leu 
465                 470                 475                 480 


Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro Glu 
                485                 490                 495     


Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val 
            500                 505                 510         


Val Asp Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp 
        515                 520                 525             


Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys 
    530                 535                 540                 


Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp Phe 
545                 550                 555                 560 


Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val Thr 
                565                 570                 575     


His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn 
            580                 585                 590         


Gln Thr Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met Ile 
        595                 600                 605             


Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp Gln 
    610                 615                 620                 


Pro Ala Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His Gly 
625                 630                 635                 640 


Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala Asn 
                645                 650                 655     


Leu Cys Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr Met 
            660                 665                 670         


Asn Glu Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His Leu 
        675                 680                 685             


Leu Arg Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe Arg 
    690                 695                 700                 


Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile 
705                 710                 715                 720 


Glu Pro Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu Arg 
                725                 730                 735     


Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser 
            740                 745                 750         


Gly Asp Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn Asn 
        755                 760                 765             


Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg Gly 
    770                 775                 780                 


Ser Phe Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp 
785                 790                 795                 800 


Trp Glu Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln 
                805                 810                 815     


Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val 
            820                 825                 830         


Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys Tyr 
        835                 840                 845             


Gly Asp Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp Pro 
    850                 855                 860                 


His Ala Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr Val 
865                 870                 875                 880 


Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys Gly 
                885                 890                 895     


Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly Phe 
            900                 905                 910         


Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His 
        915                 920                 925             


Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr Leu 
    930                 935                 940                 


Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly Phe 
945                 950                 955                 960 


Phe Gln Thr Arg Lys Ser 
                965     


<210>  3
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Thr Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp 
1               5                   10                  15      


Trp Glu Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro 
            20                  25                  30          


Pro Phe Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro 
        35                  40                  45              


Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe 
    50                  55                  60                  


Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro 
65                  70                  75                  80  


Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr 
                85                  90                  95      


Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro 
            100                 105                 110         


Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe 
        115                 120                 125             


Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe 
    130                 135                 140                 


Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val 
145                 150                 155                 160 


Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala 
                165                 170                 175     


Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Trp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp 
    210                 215                 220                 


Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu 
225                 230                 235                 240 


Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val 
                245                 250                 255     


Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala 
            260                 265                 270         


Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg 
        275                 280                 285             


Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu 
    290                 295                 300                 


Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly 
305                 310                 315                 320 


Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg 
                325                 330                 335     


Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile Arg 
            340                 345                 350         


Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met Asp 
        355                 360                 365             


Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn Phe 
    370                 375                 380                 


Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr Thr 
385                 390                 395                 400 


Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile Glu 
                405                 410                 415     


Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg Trp 
            420                 425                 430         


Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp Arg 
        435                 440                 445             


Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly His 
    450                 455                 460                 


Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp Pro 
465                 470                 475                 480 


Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala Thr 
                485                 490                 495     


Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro Phe 
            500                 505                 510         


Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro Gly 
        515                 520                 525             


Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly Asn 
    530                 535                 540                 


Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr Pro 
545                 550                 555                 560 


Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu Ile 
                565                 570                 575     


Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp Phe 
            580                 585                 590         


Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val Phe 
        595                 600                 605             


Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln Gln 
    610                 615                 620                 


Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr Ser 
625                 630                 635                 640 


Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met Val 
                645                 650                 655     


Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp Val 
            660                 665                 670         


Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln Pro 
        675                 680                 685             


Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro Asn 
    690                 695                 700                 


Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln Trp 
705                 710                 715                 720 


Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His Ala 
                725                 730                 735     


Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu Gly 
            740                 745                 750         


Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln Met 
        755                 760                 765             


Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln Phe 
    770                 775                 780                 


Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr Arg 
785                 790                 795                 800 


Ile Asp Pro Asn Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His Tyr 
                805                 810                 815     


Gln Ala Glu Ala Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala Asp 
            820                 825                 830         


Ala Val Leu Ile Thr Thr Ala His Ala Trp Gln His Gln Gly Lys Thr 
        835                 840                 845             


Leu Phe Ile Ser Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln Met 
    850                 855                 860                 


Ala Ile Thr Val Asp Val Glu Val Ala Ser Asp Thr Pro His Pro Ala 
865                 870                 875                 880 


Arg Ile Gly Leu Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val Asn 
                885                 890                 895     


Trp Leu Gly Leu Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr Ala 
            900                 905                 910         


Ala Cys Phe Asp Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr Pro 
        915                 920                 925             


Tyr Val Phe Pro Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu Leu 
    930                 935                 940                 


Asn Tyr Gly Pro His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile Ser 
945                 950                 955                 960 


Arg Tyr Ser Gln Gln Gln Leu Met Glu Thr Ser His Arg His Leu Leu 
                965                 970                 975     


His Ala Glu Glu Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met Gly 
            980                 985                 990         


Ile Gly Gly Asp Asp Ser Trp Ser  Pro Ser Val Ser Ala  Glu Phe Gln 
        995                 1000                 1005             


Leu Ser  Ala Gly Arg Tyr His  Tyr Gln Leu Val Trp  Cys Gln Lys 
    1010                 1015                 1020             


<210>  4
<211>  1010
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His Pro 
                85                  90                  95      


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
            100                 105                 110         


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
        115                 120                 125             


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
    130                 135                 140                 


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
145                 150                 155                 160 


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
                165                 170                 175     


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
            180                 185                 190         


Trp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg 
        195                 200                 205             


Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His 
    210                 215                 220                 


Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val 
225                 230                 235                 240 


Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg 
                245                 250                 255     


Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala 
            260                 265                 270         


His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
        275                 280                 285             


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
    290                 295                 300                 


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
305                 310                 315                 320 


Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro 
                325                 330                 335     


Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu 
            340                 345                 350         


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys 
        355                 360                 365             


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
    370                 375                 380                 


Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp 
385                 390                 395                 400 


Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
                405                 410                 415     


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
            420                 425                 430         


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val 
        435                 440                 445             


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
    450                 455                 460                 


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
465                 470                 475                 480 


Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
                485                 490                 495     


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
            500                 505                 510         


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
        515                 520                 525             


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val 
    530                 535                 540                 


Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly 
545                 550                 555                 560 


Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile 
                565                 570                 575     


Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg 
            580                 585                 590         


Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln 
        595                 600                 605             


Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu 
    610                 615                 620                 


Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala 
625                 630                 635                 640 


Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu 
                645                 650                 655     


Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe 
            660                 665                 670         


Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro 
        675                 680                 685             


Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala 
    690                 695                 700                 


His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln 
705                 710                 715                 720 


Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala 
                725                 730                 735     


Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu 
            740                 745                 750         


Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr 
        755                 760                 765             


Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu 
    770                 775                 780                 


Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp 
785                 790                 795                 800 


Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys 
                805                 810                 815     


Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr 
            820                 825                 830         


Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp 
        835                 840                 845             


Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu 
    850                 855                 860                 


Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu 
865                 870                 875                 880 


Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala 
                885                 890                 895     


Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala 
            900                 905                 910         


Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr 
        915                 920                 925             


Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys 
    930                 935                 940                 


Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe 
945                 950                 955                 960 


Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr 
                965                 970                 975     


Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala Ser Ile 
            980                 985                 990         


Ile Ser Leu Ser Leu Ile Phe Tyr  Tyr Ser Lys Lys Gly  Arg Arg Ser 
        995                 1000                 1005             


Tyr Lys  
    1010 


<210>  5
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  6
<211>  1014
<212>  PRT
<213>  Rattus rattus

<400>  6

Met Pro Ala Arg Ala Pro Pro Arg Arg Leu Pro Arg Leu Leu Leu Leu 
1               5                   10                  15      


Arg Leu Leu Ser Leu His Leu Leu Leu Leu Thr Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Pro Pro Val Pro Glu Ala Ser Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Pro Arg Ala Ile Pro Glu Asp Ser Pro Ile Val Met Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Leu Pro Pro Leu Pro Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp Arg Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Thr Pro Arg Arg Met Thr Asp Tyr His Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Lys Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Phe Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Ser Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Arg Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Ser Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asn Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Ile Gln Val Asp Pro Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp 
                565                 570                 575     


Phe Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Thr Gln Val Asn Arg Thr Val Leu His Phe Tyr Arg Cys Met 
    610                 615                 620                 


Val Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Ala Thr Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala 
            660                 665                 670         


Asn Leu Cys Phe Glu Glu Leu Gly His Trp Val Lys Phe Trp Ile Thr 
        675                 680                 685             


Ile Asn Glu Pro Asn Ser Arg Asn Met Thr Tyr Arg Ala Gly His His 
    690                 695                 700                 


Leu Leu Lys Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe 
705                 710                 715                 720 


Arg Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Val Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Val Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro His Val Met Arg Glu Trp Leu Asn Gln Lys Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Arg 
785                 790                 795                 800 


Gly Ser Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Trp Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Asn Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Ala Leu Asn Trp Leu Arg Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Phe Val Thr Ala Asn Gly Ile Asp Asp Asp 
865                 870                 875                 880 


Pro His Ala Glu Gln Asp Ser Leu Arg Met Tyr Tyr Ile Lys Asn Tyr 
                885                 890                 895     


Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Gly Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Val Pro Lys Ser Gly 
        915                 920                 925             


Phe Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Ile Lys 
    930                 935                 940                 


His Tyr Arg Lys Ile Ile Asp Asn Asn Gly Phe Leu Gly Ser Gly Thr 
945                 950                 955                 960 


Leu Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Gly Cys Gly 
                965                 970                 975     


Phe Phe Gln Thr Arg Lys Ser Leu Leu Ala Phe Ile Ser Phe Leu Val 
            980                 985                 990         


Phe Ala Phe Val Thr Ser Leu Ala  Leu Ile Tyr Tyr Tyr  Ser Lys Lys 
        995                 1000                 1005             


Gly Arg  Arg Arg Tyr Lys 
    1010                 


<210>  7
<211>  983
<212>  PRT
<213>  Rattus rattus

<400>  7

Met Pro Ala Arg Ala Pro Pro Arg Arg Leu Pro Arg Leu Leu Leu Leu 
1               5                   10                  15      


Arg Leu Leu Ser Leu His Leu Leu Leu Leu Thr Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Pro Pro Val Pro Glu Ala Ser Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Pro Arg Ala Ile Pro Glu Asp Ser Pro Ile Val Met Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Leu Pro Pro Leu Pro Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp Arg Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Thr Pro Arg Arg Met Thr Asp Tyr His Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Lys Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Phe Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Ser Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Arg Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Ser Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asn Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Ile Gln Val Asp Pro Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp 
                565                 570                 575     


Phe Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Thr Gln Val Asn Arg Thr Val Leu His Phe Tyr Arg Cys Met 
    610                 615                 620                 


Val Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Ala Thr Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala 
            660                 665                 670         


Asn Leu Cys Phe Glu Glu Leu Gly His Trp Val Lys Phe Trp Ile Thr 
        675                 680                 685             


Ile Asn Glu Pro Asn Ser Arg Asn Met Thr Tyr Arg Ala Gly His His 
    690                 695                 700                 


Leu Leu Lys Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe 
705                 710                 715                 720 


Arg Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Val Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Val Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro His Val Met Arg Glu Trp Leu Asn Gln Lys Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Arg 
785                 790                 795                 800 


Gly Ser Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Trp Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Asn Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Ala Leu Asn Trp Leu Arg Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Phe Val Thr Ala Asn Gly Ile Asp Asp Asp 
865                 870                 875                 880 


Pro His Ala Glu Gln Asp Ser Leu Arg Met Tyr Tyr Ile Lys Asn Tyr 
                885                 890                 895     


Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Gly Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Val Pro Lys Ser Gly 
        915                 920                 925             


Phe Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Ile Lys 
    930                 935                 940                 


His Tyr Arg Lys Ile Ile Asp Asn Asn Gly Phe Leu Gly Ser Gly Thr 
945                 950                 955                 960 


Leu Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Gly Cys Gly 
                965                 970                 975     


Phe Phe Gln Thr Arg Lys Ser 
            980             


<210>  8
<211>  1013
<212>  PRT
<213>  Macaca speciosa

<400>  8

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Ala Gly Arg Arg 
            20                  25                  30          


Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Ile Ala Asn Val Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Asp His Ser Ile Lys Glu Cys Gln Lys Ser 
305                 310                 315                 320 


Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly 
                325                 330                 335     


Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp 
            340                 345                 350         


Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe 
        355                 360                 365             


Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His 
    370                 375                 380                 


Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser 
385                 390                 395                 400 


Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn 
                405                 410                 415     


Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met 
            420                 425                 430         


Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu 
        435                 440                 445             


Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly 
    450                 455                 460                 


Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val 
465                 470                 475                 480 


Asp Phe Leu Ser Gln Glu Lys Thr Leu Leu Pro Lys Ser Ser Ala Leu 
                485                 490                 495     


Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu 
            500                 505                 510         


Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Ile 
        515                 520                 525             


Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp 
    530                 535                 540                 


Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys 
545                 550                 555                 560 


Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe 
                565                 570                 575     


Ala Ala Ile Gln Pro Gln Ile Thr Leu Leu Gln Glu Met His Val Thr 
            580                 585                 590         


His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn 
        595                 600                 605             


Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Val 
    610                 615                 620                 


Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln 
625                 630                 635                 640 


Pro Val Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly 
                645                 650                 655     


Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg 
            660                 665                 670         


Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met 
        675                 680                 685             


Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu 
    690                 695                 700                 


Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg 
705                 710                 715                 720 


His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile 
                725                 730                 735     


Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg 
            740                 745                 750         


Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser 
        755                 760                 765             


Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn 
    770                 775                 780                 


Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly 
785                 790                 795                 800 


Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp 
                805                 810                 815     


Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln 
            820                 825                 830         


Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val 
        835                 840                 845             


Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr 
    850                 855                 860                 


Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu 
865                 870                 875                 880 


His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile 
                885                 890                 895     


Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly 
            900                 905                 910         


Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu 
        915                 920                 925             


Tyr Arg Phe Ala Ala Asp Gln Phe Glu Pro Lys Pro Ser Met Lys His 
    930                 935                 940                 


Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu 
945                 950                 955                 960 


Glu Lys Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe 
                965                 970                 975     


Phe His Thr Arg Lys Pro Leu Val Ala Phe Ile Ala Phe Leu Phe Phe 
            980                 985                 990         


Ala Phe Ile Val Ser Leu Ser Leu  Ile Phe Tyr Tyr Ser  Lys Lys Gly 
        995                 1000                 1005             


Arg Arg  Arg Tyr Gln 
    1010             


<210>  9
<211>  983
<212>  PRT
<213>  Macaca speciosa

<400>  9

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Ala Gly Arg Arg 
            20                  25                  30          


Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Ile Ala Asn Val Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


His Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Glu Lys Thr Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Ile Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp 
                565                 570                 575     


Phe Ala Ala Ile Gln Pro Gln Ile Thr Leu Leu Gln Glu Met His Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met 
    610                 615                 620                 


Val Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Val Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala 
            660                 665                 670         


Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr 
        675                 680                 685             


Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn 
    690                 695                 700                 


Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe 
705                 710                 715                 720 


Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln 
785                 790                 795                 800 


Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly 
865                 870                 875                 880 


Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr 
                885                 890                 895     


Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly 
        915                 920                 925             


Leu Tyr Arg Phe Ala Ala Asp Gln Phe Glu Pro Lys Pro Ser Met Lys 
    930                 935                 940                 


His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr 
945                 950                 955                 960 


Leu Glu Lys Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser 
                965                 970                 975     


Phe Phe His Thr Arg Lys Pro 
            980             


<210>  10
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala Arg Ala Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Arg 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Ser 
    50                  55                  60                  


Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro Ser Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Thr 
        115                 120                 125             


Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Val 
    210                 215                 220                 


Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Asn Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp Phe Ser Ala 
    530                 535                 540                 


Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Thr 
                565                 570                 575     


Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met Ile Ser Glu 
            580                 585                 590         


Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Ala 
        595                 600                 605             


Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala Asn Leu Cys 
625                 630                 635                 640 


Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His Leu Leu Arg 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe Arg Ala Ala 
        675                 680                 685             


Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg Gly Ser Phe 
        755                 760                 765             


Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu 
    770                 775                 780                 


Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp Pro His Ala 
        835                 840                 845             


Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr Val Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly Phe Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg 
            900                 905                 910         


Arg Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr Leu Gly Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly Phe Phe Gln 
    930                 935                 940                 


Thr Arg Lys Ser His His His His His His 
945                 950                 


<210>  11
<211>  948
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala Arg Ala Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Arg 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Ser 
    50                  55                  60                  


Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro Ser Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Thr 
        115                 120                 125             


Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Val 
    210                 215                 220                 


Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Asn Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp Phe Ser Ala 
    530                 535                 540                 


Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Thr 
                565                 570                 575     


Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met Ile Ser Glu 
            580                 585                 590         


Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Ala 
        595                 600                 605             


Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala Asn Leu Cys 
625                 630                 635                 640 


Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His Leu Leu Arg 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe Arg Ala Ala 
        675                 680                 685             


Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg Gly Ser Phe 
        755                 760                 765             


Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu 
    770                 775                 780                 


Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp Pro His Ala 
        835                 840                 845             


Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr Val Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly Phe Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr Leu Gly Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly Phe Phe Gln 
    930                 935                 940                 


Thr Arg Lys Ser 
945             


